POEM of the Week Podcast

Episode 657: Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND)

Play Episode Listen Later Mar 20, 2023 6:41

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Early invasive strategy does not reduce mortality for moderate to severe ischemic heart disease after 5.8 years (ISCHEMIA-EXTEND) '

strategy reduce poem severe extend mortality heart disease moderate invasive wilkes ischemia ischemic

Episode 656: Among antidepressants, only serotonin-norepinephrine reuptake inhibitors are effective for pain

Play Episode Listen Later Mar 13, 2023 4:59

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Among antidepressants, only serotonin-norepinephrine reuptake inhibitors are effective for pain '

pain poem serotonin antidepressants wilkes inhibitors norepinephrine

Episode 655: Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9)

Play Episode Listen Later Mar 6, 2023 6:33

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Low FODMAPS diet is better than an oral spasmolytic for irritable bowel syndrome (NNT = 7 – 9) '

diet poem oral wilkes irritable bowel syndrome fodmaps nnt

Episode 654: Letrozole more efficacious than clomiphene for infertility treatment among individuals with polycystic ovarian syndrome

Play Episode Listen Later Feb 27, 2023 4:31

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Letrozole more efficacious than clomiphene for infertility treatment among individuals with polycystic ovarian syndrome '

treatments individuals poem wilkes polycystic ovarian syndrome efficacious infertility treatment letrozole

Episode 653: Brief behavioral therapy diminishes insomnia in the elderly

Play Episode Listen Later Feb 20, 2023 5:54

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Brief behavioral therapy diminishes insomnia in the elderly '

poem insomnia elderly wilkes behavioral therapy diminishes

Episode 652: Mindfulness-based stress reduction is noninferior to escitalopram for adults with anxiety disorder

Play Episode Listen Later Feb 13, 2023 7:16

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Mindfulness-based stress reduction is noninferior to escitalopram for adults with anxiety disorder '

mindfulness adults poem anxiety disorders wilkes mindfulness based stress reduction escitalopram

Episode 651: No benefit with torsemide over furosemide for posthospitalization treatment of heart failure (TRANSFORM-HF)

Play Episode Listen Later Feb 6, 2023 5:27

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' No benefit with torsemide over furosemide for posthospitalization treatment of heart failure (TRANSFORM-HF) '

treatments transform benefit poem heart failure wilkes furosemide

Episode 650: Lecanemab does not significantly improve cognition in early Alzheimer's disease, is expensive, and causes brain edema and hemorrhage in some patients

Play Episode Listen Later Jan 30, 2023 8:38

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Lecanemab does not significantly improve cognition in early Alzheimer's disease, is expensive, and causes brain edema and hemorrhage in some patients '

brain patients alzheimer's disease expensive poem cognition wilkes hemorrhage edema

Episode 649: Chlorthalidone no better than hydrochlorothiazide for hypertension

Play Episode Listen Later Jan 23, 2023 6:26

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Chlorthalidone no better than hydrochlorothiazide for hypertension '

poem hypertension wilkes

Episode 648: Twice-daily low-dose aspirin is similar to enoxaparin for thromboprophylaxis after inpatient treatment for fracture (PREVENT CLOT)

Play Episode Listen Later Jan 16, 2023 6:34

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Twice-daily low-dose aspirin is similar to enoxaparin for thromboprophylaxis after inpatient treatment for fracture (PREVENT CLOT) '

treatments prevent similar poem fracture wilkes inpatient clot low dose aspirin thromboprophylaxis

Episode 647: Tell patients their new knee won't wear out sooner with hard use

Play Episode Listen Later Jan 9, 2023 7:33

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tell patients their new knee won't wear out sooner with hard use '

patients wear poem knee sooner wilkes

Episode 646: Majority of CIN2 regress in women aged 25 to 30 years

Play Episode Listen Later Jan 2, 2023 6:08

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Majority of CIN2 regress in women aged 25 to 30 years '

women poem majority aged wilkes regress

Episode 645: Morning and bedtime dosing of antihypertensives have similar rates of major cardiovascular events (TIME)

Play Episode Listen Later Dec 26, 2022 5:00

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Morning and bedtime dosing of antihypertensives have similar rates of major cardiovascular events (TIME) '

Episode 644: Use of ACEIs and ARBs in advanced chronic kidney disease does not worsen, and may improve, renal outcomes

Play Episode Listen Later Dec 19, 2022 7:08

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Use of ACEIs and ARBs in advanced chronic kidney disease does not worsen, and may improve, renal outcomes '

poem outcomes renal wilkes chronic kidney disease arbs

Episode 643: Invitation to a single colonoscopy has only modest impact on colorectal cancer incidence (NordICC)

Play Episode Listen Later Dec 12, 2022 7:17

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Invitation to a single colonoscopy has only modest impact on colorectal cancer incidence (NordICC) '

single invitation poem modest colonoscopies wilkes colorectal cancer incidence

Episode 642: Tocilizumab beneficial for adults with persistent polymyalgia rheumatica symptoms who receive steroid therapy

Play Episode Listen Later Dec 5, 2022 5:20

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tocilizumab beneficial for adults with persistent polymyalgia rheumatica symptoms who receive steroid therapy '

therapy receive adults symptoms poem steroids persistent wilkes polymyalgia

Episode 641: Improved decongestion with the addition of acetazolamide to intravenous loop diuretics for acute heart failure

Play Episode Listen Later Nov 28, 2022 5:04

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Improved decongestion with the addition of acetazolamide to intravenous loop diuretics for acute heart failure '

loop poem improved addition acute heart failure wilkes intravenous diuretics

Episode 640: Rebound symptoms common with COVID-19 even after placebo treatment

Play Episode Listen Later Nov 21, 2022 5:42

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Rebound symptoms common with COVID-19 even after placebo treatment '

covid-19 treatments symptoms poem rebound placebos wilkes

Episode 639: Limited evidence for meds, music, and massage to treat anxiety in residents of long-term care facilities

Play Episode Listen Later Nov 14, 2022 6:23

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Limited evidence for meds, music, and massage to treat anxiety in residents of long-term care facilities '

music anxiety treat limited poem massage facilities residents meds long term care wilkes

Episode 638: Percutaneous coronary intervention does not improve outcomes for patients with ischemic heart disease and LVEF of less than 35%

Play Episode Listen Later Nov 7, 2022 5:59

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Percutaneous coronary intervention does not improve outcomes for patients with ischemic heart disease and LVEF of less than 35% '

patients poem intervention heart disease wilkes coronary improve outcomes ischemic percutaneous lvef

Episode 637: Nonpharmacologic approaches can improve fibromyalgia symptoms

Play Episode Listen Later Oct 31, 2022 4:44

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nonpharmacologic approaches can improve fibromyalgia symptoms '

symptoms poem approaches fibromyalgia wilkes

Episode 636: Amitriptyline, duloxetine, and pregabalin each effective in decreasing pain from diabetic peripheral neuropathy; combinations even better

Play Episode Listen Later Oct 24, 2022 5:35

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Amitriptyline, duloxetine, and pregabalin each effective in decreasing pain from diabetic peripheral neuropathy; combinations even better '

pain poem diabetic even better decreasing wilkes combinations peripheral neuropathy pregabalin

Episode 635: Liraglutide probably the best second drug to prevent cardiovascular events in patients with T2DM who take metformin

Play Episode Listen Later Oct 17, 2022 7:08

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Liraglutide probably the best second drug to prevent cardiovascular events in patients with T2DM who take metformin '

patients drug prevent poem wilkes metformin t2dm cardiovascular events liraglutide

Episode 634: Polypill better for secondary cardiovascular prevention than physician-directed care

Play Episode Listen Later Oct 10, 2022 7:39

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Polypill better for secondary cardiovascular prevention than physician-directed care '

care physicians directed poem secondary wilkes cardiovascular prevention

Episode 633: Nirmatrelvir/ritonavir (Paxlovid) reduces hospitalization, mortality in patients 65+ with COVID-19; effect on younger patients unclear

Play Episode Listen Later Oct 3, 2022 6:10

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nirmatrelvir/ritonavir (Paxlovid) reduces hospitalization, mortality in patients 65+ with COVID-19; effect on younger patients unclear '

covid-19 patients younger poem mortality reduces hospitalization unclear wilkes

Episode 632: Likelihood of long COVID varies by variant, sex, and vaccination status

Play Episode Listen Later Sep 26, 2022 5:58

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Likelihood of long COVID varies by variant, sex, and vaccination status '

covid-19 status vaccination poem variant long covid wilkes likelihood varies

Episode 631: Pharmacogenomic testing for selection of antidepressant provides minimal, if any, benefit (PRIME)

Play Episode Listen Later Sep 19, 2022 5:44

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Overuse alert: Pharmacogenomic testing for selection of antidepressant provides minimal, if any, benefit (PRIME) '

testing benefit prime selection poem minimal antidepressants wilkes overuse

Episode 630: Greater social determinants of health burden associated with an increased risk of hospitalization

Play Episode Listen Later Sep 12, 2022 6:50

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Greater social determinants of health burden associated with an increased risk of hospitalization '

burden poem hospitalization wilkes social determinants of health increased risk

Episode 629: Tirzepatide helps obese adults without diabetes lose 15% to 21% of their body weight over 72 weeks

Play Episode Listen Later Sep 5, 2022 7:26

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Tirzepatide helps obese adults without diabetes lose 15% to 21% of their body weight over 72 weeks '

helps diabetes adults poem obese bodyweight wilkes

Episode 628: Supplemental vitamin D does not reduce the risk of fracture in older adults (VITAL)

Play Episode Listen Later Aug 29, 2022 8:12

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Supplemental vitamin D does not reduce the risk of fracture in older adults (VITAL) '

risk reduce vital poem vitamins vitamin d fracture supplemental older adults wilkes

Episode 627: Screening for atrial fibrillation in primary care is not effective (VITAL-AF)

Play Episode Listen Later Aug 22, 2022 6:51

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Screening for atrial fibrillation in primary care is not effective (VITAL-AF) '

vital poem screenings primary care wilkes atrial fibrillation

Episode 626: Fewer than 4% of children with newly diagnosed hypertension in primary care or school settings have secondary causes

Play Episode Listen Later Aug 15, 2022 5:00

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Fewer than 4% of children with newly diagnosed hypertension in primary care or school settings have secondary causes '

children school poem secondary settings primary care hypertension wilkes newly diagnosed

Episode 625: Minimal difference, if any, in the efficacy of intramuscular vs intra-articular steroid injection for knee osteoarthritis

Play Episode Listen Later Aug 8, 2022 6:42

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Minimal difference, if any, in the efficacy of intramuscular vs intra-articular steroid injection for knee osteoarthritis '

poem steroids minimal efficacy injection intra wilkes articular knee osteoarthritis

Episode 624: Long-term risks are similar for CT and invasive coronary angiography as initial diagnostic strategy for stable chest pain

Play Episode Listen Later Aug 1, 2022 6:50

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Long-term risks are similar for CT and invasive coronary angiography as initial diagnostic strategy for stable chest pain '

strategy long term risks similar poem initial stable diagnostic invasive wilkes coronary chest pain angiography

Episode 623: Medication abortion for pregnancy of unknown location a reasonable option

Play Episode Listen Later Jul 25, 2022 7:32

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Medication abortion for pregnancy of unknown location a reasonable option '

abortion pregnancy unknown option location poem medications reasonable wilkes

Episode 622: USPSTF 2022 recommends against initiating aspirin for primary prevention of cardiovascular disease in adults 60+ years (D recommendation)

Play Episode Listen Later Jul 18, 2022 7:00

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' USPSTF 2022 recommends against initiating aspirin for primary prevention of cardiovascular disease in adults 60+ years (D recommendation) '

adults recommendations poem cardiovascular diseases aspirin wilkes initiating primary prevention uspstf

Episode 621: Aducanumab is not effective for mild cognitive impairment or mild Alzheimer's dementia and has major safety issues

Play Episode Listen Later Jul 11, 2022 8:27

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Aducanumab is not effective for mild cognitive impairment or mild Alzheimer's dementia and has major safety issues '

alzheimer's disease poem dementia wilkes safety issues mild cognitive impairment aducanumab

Episode 620: Surgery is no better than nonoperative treatment for Achilles tendon rupture in adults

Play Episode Listen Later Jul 4, 2022 5:35

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Surgery is no better than nonoperative treatment for Achilles tendon rupture in adults '

treatments adults surgery poem rupture wilkes achilles tendon nonoperative treatment

Episode 619: Ketamine reduces suicidal ideation quickly, but may not reduce the short-term likelihood of suicide attempts

Play Episode Listen Later Jun 27, 2022 5:53

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Ketamine reduces suicidal ideation quickly, but may not reduce the short-term likelihood of suicide attempts '

poem short term ketamine reduces wilkes likelihood suicide attempts suicidal ideation

Episode 618: Combination antidepressant therapy is more effective than monotherapy for acute severe depression and nonresponding depression

Play Episode Listen Later Jun 20, 2022 5:55

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Combination antidepressant therapy is more effective than monotherapy for acute severe depression and nonresponding depression '

depression poem severe acute combination antidepressants wilkes monotherapy

Episode 617: Closed-loop system improves glycemic control but not hypoglycemia for young children with type 1 diabetes mellitus

Play Episode Listen Later Jun 13, 2022 5:38

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Closed-loop system improves glycemic control but not hypoglycemia for young children with type 1 diabetes mellitus '

system closed poem improves type1 young children type 1 diabetes wilkes diabetes mellitus hypoglycemia closed loop glycemic control

Episode 616: Selective serotonin reuptake inhibitors are probably the best first option for patients with panic disorder

Play Episode Listen Later Jun 6, 2022 6:14

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Selective serotonin reuptake inhibitors are probably the best first option for patients with panic disorder '

patients option disorders poem selective serotonin wilkes inhibitors panic disorder

Episode 615: All-cause mortality is comparable in patients with left main coronary artery disease treated with PCI or CABG

Play Episode Listen Later May 30, 2022 5:00

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' All-cause mortality is comparable in patients with left main coronary artery disease treated with PCI or CABG '

left patients poem mortality treated wilkes pci arteries comparable coronary artery disease cabg

Episode 614: MA: Several drugs are effective for weight loss in obese or overweight adults; it's unclear whether they improve health outcomes

Play Episode Listen Later May 23, 2022 7:01

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' MA: Several drugs are effective for weight loss in obese or overweight adults; it's unclear whether they improve health outcomes '

drugs weight loss adults poem overweight obese unclear wilkes health outcomes improve health

Episode 613: Large increases in the risk of cardiovascular events following COVID-19 infection that required hospitalization

Play Episode Listen Later May 16, 2022 7:19

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Large increases in the risk of cardiovascular events following COVID-19 infection that required hospitalization '

covid-19 risk large required poem infection increases hospitalization wilkes cardiovascular events

Episode 612: Thromboprophylaxis after discharge improves clinical outcomes for certain high-risk patients hospitalized with COVID-19 (MICHELLE)

Play Episode Listen Later May 9, 2022 6:11

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Thromboprophylaxis after discharge improves clinical outcomes for certain high-risk patients hospitalized with COVID-19 (MICHELLE) '

covid-19 poem improves high risk discharge wilkes clinical outcomes patients hospitalized thromboprophylaxis

Episode 611: Ibuprofen, ketorolac, and diclofenac are equivalent for the treatment of acute nonradicular low back pain

Play Episode Listen Later May 2, 2022 5:23

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Ibuprofen, ketorolac, and diclofenac are equivalent for the treatment of acute nonradicular low back pain '

treatments poem acute wilkes equivalent low back pain ibuprofen diclofenac ketorolac

Episode 610: Proton pump inhibitor use associated with an increased risk of gastric cancer

Play Episode Listen Later Apr 25, 2022 7:00

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Proton pump inhibitor use associated with an increased risk of gastric cancer '

poem wilkes proton increased risk gastric cancer proton pump inhibitors

Episode 609: British Society of Gastroenterology guidelines for the management of irritable bowel syndrome

Play Episode Listen Later Apr 18, 2022 6:39

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' British Society of Gastroenterology guidelines for the management of irritable bowel syndrome '

management guidelines poem gastroenterology wilkes irritable bowel syndrome british society

Episode 608: Nirmatrelvir/ritonavir (Paxlovid) reduces risk of hospitalization in at-risk outpatients (EPIC-HR)

Play Episode Listen Later Apr 11, 2022 6:50

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' Nirmatrelvir/ritonavir (Paxlovid) reduces risk of hospitalization in at-risk outpatients (EPIC-HR) '

risk epic poem reduces hospitalization wilkes outpatients

Episode 607: No improved patient-oriented outcomes with sacubitril/valsartan in adults with heart failure and preserved EF (PARALLAX)

Play Episode Listen Later Apr 4, 2022 6:40

Dr. Ebell and Dr. Wilkes discuss the POEM titled ' No improved patient-oriented outcomes with sacubitril/valsartan in adults with heart failure and preserved EF (PARALLAX) '

patients adults poem outcomes improved oriented preserved heart failure wilkes parallax valsartan