Podcasts about Intra

 It's World Series time! Mat & Mark break down the 2025 matchup between the Toronto Blue Jays and Los Angeles Dodgers, diving into the storylines, rivalries, and what this series means for both nations. Dodgers will not take their foot off the gas pedalTyler Glasnow is kind of a hit and miss pitcher, howeverBlake Snell pitching effectiveness for the DodgersBatting power with Ernie ClementBlue Jays players are 150% behind their managerIf Toronto takes 1 or 2 of the games in LA it could be a 6 or 7 game World SeriesFormer Blue Jay, Teoscar Hernandez is a powerful hitter for Dodgers, he will be able to deliver the scouting dirt on his former teamThe return of Bo Bichette Question on depth of Blue Jays bullpenMax Scherzer will be able to offer insight on his former team, the DodgersMariners suffered with bullpen against the Blue Jays – certainly with George SpringerJays Scherzer & Chris Bassitt – will they pitch more innings in World SeriesMarinersLogan Gilbert did not have his best results against the Blue JaysGetting to know Bazardo     Facing George Springer at bat “Mariners Coach Dan Wilson's fearful look during their games with the Blue JaysJays Schneider exudes confidenceMLB 2025 Postseason Strong viewership this yearALCS, between the Mariners and the Blue Jays, had 10 million viewers, a 32% increase in viewership over previous yearPlayoffs games are averaging 4.3 million viewers. a 30% increase over last yearALDS game 5 drew 8.72 million viewers – most viewership since 2011ALCS, between the Mariners and the Blue Jays, had 10 million viewers - 32% increase in viewership over previous yearPlayoffs games are averaging 4.3 million viewers. a 30% increase over last yearALDS game 5 drew 8.72 million viewers – most viewership since 2011Canadian audience contributed significantly to all of the numbersGame 7 of the ALCS - record breaking viewership on SportsNet and SportsNet Plus, which brought in 11.8 million Canadians to the broadcastWPBL League announces 4 city locations for 2026 launch – Boston, New York, Los Angeles & San FranciscoHow will WPBL build audience to watch the game via tv, streaming & etcMo'ne DavisJustine Siegal instrumental with Baseball For All & now WPBLNeed for Intra-sport support across MLB, NHL, NFLWinter League games w/Major Leaguers like Nick Castellanos, Jason ChourioSports Equinox  - Get your remotes, popcorn and pizza ready - Monday, October 27, 2025, games being played across MLB, NHL & NFLMat's journey to the Baltimore ESPN zone Harold Ramirez still out their working in Mexican League to get back into MLBRaysUp – what is coming up with Pete Alonso & Luis ArráezMLB “Meritocracy” Debate: MLB's diversity page changes spark discussion on inclusivity and representation. DEI – DoD – Jackie Robinson take down and the brought back upMLB.com changes to their DEI pages -  less inclusive of diversity than before?Be aware of GroupThinkAliens & Epstein files soon to be releasedGo Jays!Find Mat at @matgermain.bsky.social or reach Mark @  baseballbizondeck@gmail.com BaseballBiz on Deck, @ iHeart Apple, Spotify, Amazon Music, and at www.baseballbizOnDeck.com Special Thanks to XTaKe-R-U-X for the music "Rocking Forward"

Show notes at pharmacyjoe.com/episode1071. In this episode, I'll discuss whether a nasal MRSA screen is useful for choosing antibiotics in critically ill patients with an intraabdominal infection. The post 1071: Can a nasal MRSA screen be useful for choosing antibiotics in critically ill patients with an intra abdominal infection? appeared first on Pharmacy Joe.

➡️ Check Out ZONE (Jim Brown's Nootropic Formula): https://forjlife.com/collections/all   ➡️ Want To Learn More About Partnering With Me at eXp (Get all my Training & Coaching For Free) Schedule a Zero Pressure, Fully Confidential Zoom Call with me: https://go.oncehub.com/PartnerwithJoshuaSmithGSD   ➡️ Connect With Me On Social Media: Facebook: https://www.facebook.com/JoshuaSmithGSD Instagram: https://instagram.com/joshuasmithgsd/   About Joshua Smith: -Licensed Realtor/Team Leader Since 2005 -Voted 30th Top Realtor in America by The Wall Street Journal -NAR "30 Under 30" Finalist -Named Top 100 Most Influential People In Real Estate -Top 1% of Realtors/Team Leaders Worldwide -6000+ Homes Sold & Currently Selling 1+ Homes Daily -Featured In: Forbes, Wall Street Journal, Inman & Realtor Magazine -Realtor, Team Leader, Coach, Mentor

Editor's Summary by Linda Brubaker, MD, and Preeti Malani, MD, MSJ, Deputy Editors of JAMA, the Journal of the American Medical Association, for articles published from October 11-17, 2025.

Stephen Grootes speaks to Reggie Mlangeni, Head of Global Markets Sales & Structuring at Absa CIB, about five priorities Africa must focus on to boost intra-continental trade in an increasingly fragmented global economy. Mlangeni notes that while the African Continental Free Trade Area (AfCFTA) holds great promise, it cannot quickly replace the export markets Africa risks losing amid global trade shifts. The Money Show is a podcast hosted by well-known journalist and radio presenter, Stephen Grootes. He explores the latest economic trends, business developments, investment opportunities, and personal finance strategies. Each episode features engaging conversations with top newsmakers, industry experts, financial advisors, entrepreneurs, and politicians, offering you thought-provoking insights to navigate the ever-changing financial landscape.    Thank you for listening to a podcast from The Money Show Listen live Primedia+ weekdays from 18:00 and 20:00 (SA Time) to The Money Show with Stephen Grootes broadcast on 702 https://buff.ly/gk3y0Kj and CapeTalk https://buff.ly/NnFM3Nk For more from the show, go to https://buff.ly/7QpH0jY or find all the catch-up podcasts here https://buff.ly/PlhvUVe Subscribe to The Money Show Daily Newsletter and the Weekly Business Wrap here https://buff.ly/v5mfetc The Money Show is brought to you by Absa     Follow us on social media   702 on Facebook: https://www.facebook.com/TalkRadio702 702 on TikTok: https://www.tiktok.com/@talkradio702 702 on Instagram: https://www.instagram.com/talkradio702/ 702 on X: https://x.com/CapeTalk 702 on YouTube: https://www.youtube.com/@radio702   CapeTalk on Facebook: https://www.facebook.com/CapeTalk CapeTalk on TikTok: https://www.tiktok.com/@capetalk CapeTalk on Instagram: https://www.instagram.com/ CapeTalk on X: https://x.com/Radio702 CapeTalk on YouTube: https://www.youtube.com/@CapeTalk567 See omnystudio.com/listener for privacy information.

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La lista del mese delle scadenze da ricordare

durée : 00:01:59 - Beauté et bien-être, ici RCFM - Ajoutons aujourd'hui une nouvelle corde à notre arc ! Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.

Investors often believe that when markets “recover,” their portfolios do too — but that's a dangerous illusion. In this episode, Lance Roberts breaks down why percentage losses and gains are not symmetrical, and how a 50% loss requires a 100% gain just to break even. We'll discuss why bear market math destroys long-term returns, how emotional investors get trapped in the “illusion of recovery,” and why managing risk during drawdowns matters more than chasing every rally. 0:19 - The First Full Trading Week of October - Action 4:11 - Markets - Overbought & Overconfident? 9:27 - Where is the Promised Recession? 12:06 - What is Supporting the Market? 15:53 - The Overall Liquidity Base is Still Flush 19:19 - Annual vs Intra-year Returns Comparison 22:18 - Understanding Losses in Bear Markets - not symmetrical 27:02 - The Math of Loss 29:32 - The Importance of Understanding the Difference Between Points & Percentages 33:49 - Why Markets Do Not Compound 34:19 - The Function of Time on Investments 39:26 - Six Strategies That Work When Markets Don't 46:48 - Preview: Trading Guide Rules from Master Investors

Investors often believe that when markets “recover,” their portfolios do too — but that's a dangerous illusion. In this episode, Lance Roberts breaks down why percentage losses and gains are not symmetrical, and how a 50% loss requires a 100% gain just to break even. We'll discuss why bear market math destroys long-term returns, how emotional investors get trapped in the “illusion of recovery,” and why managing risk during drawdowns matters more than chasing every rally. 0:19 - The First Full Trading Week of October - Action 4:11 - Markets - Overbought & Overconfident? 9:27 - Where is the Promised Recession? 12:06 - What is Supporting the Market?  15:53 - The Overall Liquidity Base is Still Flush 19:19 - Annual vs Intra-year Returns Comparison 22:18 - Understanding Losses in Bear Markets - not symmetrical 27:02 - The Math of Loss 29:32 - The Importance of Understanding the Difference Between Points & Percentages 33:49 - Why Markets Do Not Compound 34:19 - The Function of Time on Investments 39:26 - Six Strategies That Work When Markets Don't 46:48 - Preview: Trading Guide Rules from Master Investors

Kenan a grandi dans sa famille paternelle, où les violences intra-familiales étaient quotidiennes. À l'âge de 9 ans, son cousin abuse de lui et son père l'empêche de parler, afin de ne pas ternir la réputation de la famille. Aujourd'hui, Kenan brise le silence, témoigne et sensibilise à travers son livre, mais également au sein d'associations. Hébergé par Audion. Visitez https://www.audion.fm/fr/privacy-policy pour plus d'informations.

The benchmark US equity indices booked another round of fresh record intra-day and closing highs to open the week - Dow edged +66-points or +0.14% to 46,381.54. Apple Inc rallied +4.31% to be the leading performer in the 30-stock index following reports of strong demand for the iPhone 17 in its first weekend of sales, aided by consumers seeking to replace aging devices. The stock is closing in on a fresh record closing high (after touching their highest intra-day level since December 2024 overnight at US$256.64) and market capitalisation of US$4 trillion. ‘Magnificent Seven' mega-capitalisation technology peer Nvidia Corp rallied +3.93% to a record closing high of US$183.61 after the company said it's going to invest US$100B in OpenAI - the maker of ChatGPT - for the buildout of data centres based around the company's artificial intelligence (AI) chips. The partnership "enables OpenAI to build and deploy at least 10 gigawatts of AI data centres with NVIDIA systems representing millions of GPUs [graphics processing unit] for OpenAI's next-generation AI infrastructure." Nvidia added it "intends to invest up to US$100B in OpenAI progressively as each gigawatt is deployed." However, Amazon.com Inc fell -1.66% as investors assessed the potential fallout from President Trump's shock decision late on Friday (19 September) to raise the H-1B visa application fee to US$100,000. Amazon employs ~14K staff on such visas.

https://x.com/DrDaniS/status/1960716937518100974  @thehappywifeschool  The Surprising Secrets Your Wife Holds About Sex | The Happy Wife School Show Ep. 76 https://www.youtube.com/live/ZXnj36wZmqY?si=NWL1xujOX3zzt-0c  @OrthodoxEthos  Honoring God In Sexual Relations — According to St. Porphyrios https://youtu.be/BjJI6SL4B6g?si=-__gRsfV2kZHfq6F https://www.drpsychmom.com/author/samrodman/  https://www.drpsychmom.com/what-men-think-about-sex-versus-reality/ https://www.drpsychmom.com/women-sex-vs-reality/ Why is the Church Today so Sex Positive when the Ancient Church was so Sex Negative? Livestream! https://www.youtube.com/live/DaaDihjp0gM?si=wvdPQ1WMYCx5AkpC Why is the Church Today so Sex Positive when the Ancient Church was so Sex Negative? https://youtu.be/vmq-AcRN9DY?si=KuA2ydCu9GjwWkkA Fertility Suppression by Elite Women. What is the Source of this Assault on Humanity's Future? https://youtu.be/wu56e0Ds9wo  @BenjaminABoyce  Female Psychology & The End of Empires | with Dr. Dani Sulikowski https://youtu.be/sRY_1JRRcNU?si=A3C5vu73PEu4t83J   @radicalhealthradio  Reacting to Aubrey Marcus Polyamory (“Radical Monogamy”) https://youtu.be/Vas3iUub4SY?si=c4WJMEqCgx9RYHcW  @AubreyMarcusPod  An Evolution of Sacred Union | Vylana, Alana Beale, Dr. Marc Gafni https://youtu.be/q_4_WD6-9MI?si=XHogGN-Ue2m6doh3 https://www.southeastuary.com/ https://www.southeastuary.com/ https://www.livingstonescrc.com/give Paul Vander Klay clips channel https://www.youtube.com/channel/UCX0jIcadtoxELSwehCh5QTg https://www.meetup.com/sacramento-estuary/ My Substack https://paulvanderklay.substack.com/ Bridges of meaning https://discord.gg/cfwxQ96Q Estuary Hub Link https://www.estuaryhub.com/ If you want to schedule a one-on-one conversation check here. https://calendly.com/paulvanderklay/one2one There is a video version of this podcast on YouTube at http://www.youtube.com/paulvanderklay To listen to this on ITunes https://itunes.apple.com/us/podcast/paul-vanderklays-podcast/id1394314333  If you need the RSS feed for your podcast player https://paulvanderklay.podbean.com/feed/  All Amazon links here are part of the Amazon Affiliate Program. Amazon pays me a small commission at no additional cost to you if you buy through one of the product links here. This is is one (free to you) way to support my videos.  https://paypal.me/paulvanderklay Blockchain backup on Lbry https://odysee.com/@paulvanderklay https://www.patreon.com/paulvanderklay Paul's Church Content at Living Stones Channel https://www.youtube.com/channel/UCh7bdktIALZ9Nq41oVCvW-A To support Paul's work by supporting his church give here. https://tithe.ly/give?c=2160640 https://www.livingstonescrc.com/give  

Discover why intra-Africa trade is extremely crucial for promoting economies, leveraging the continent's vast resources (population, arable land), and scaling up economic growth. We tackle the challenges faced by small producers in accessing export markets due to structural constraints, costly undertakings, and infrastructure gaps. The series calls for the removal of red tape, significant investment in physical and digital infrastructure, stable regulatory frameworks, and addressing corruption to attract investors and foster seamless trade within the continent. This episode underscores the powerful truth that "trade is better than aid" for empowering communities and building a thriving, ethical, and sustainable future for Africa. We also highlight the importance of succession planning and supporting the youth in agriculture, alongside the rapid implementation of initiatives like the African Continental Free Trade Agreement (AfCFTA).

In this gripping episode, we welcome back frequent guest and forensic mental health expert Dr. Jerrod Brown to explore the devastating phenomenon of intra-familial homicide—when murder occurs within the home, at the hands of someone trusted and loved. From uxoricide (husbands killing wives) to parricide (children murdering parents), these crimes tear at the fabric of our social and emotional understanding. Why do they happen? How can we spot the warning signs? And what role does neurocriminology play in helping us make sense of the unthinkable?

The Nasdaq 100 fell as much as 1.5% before recovering to close just 0.6% lower. Markets remain on edge ahead of key events, including Jay Powell's speech at the Jackson Hole Symposium tomorrow, whilst the USD remains unchanged and gold rises amid concerns over Fed independence. UK inflation surged to an 18-month high and government bonds rallied, lifting large-cap UK stocks, whilst Asian markets showed mixed results, with technology-heavy Korea and Taiwan rising and Japan's Nikkei 225 falling. Shares in Shanghai have reached their highest in a decade. Carsten Menke, Head of Next Generation Research, discusses the Circular Economy investment theme, focusing on the plastic problem.(00:00) - Introduction: Helen Freer, Product & Investment Content (00:28) - Markets wrap-up: Mike Rauber, Product & Investment Content (06:34) - Circular Economy: Carsten Menke, Head of Next Generation Research (10:26) - Closing remarks: Helen Freer, Product & Investment Content Would you like to support this show? Please leave us a review and star rating on Apple Podcasts, Spotify or wherever you get your podcasts.

In this episode, Dr. Sergio Zanotti discusses ECPR–Extracorporeal Cardiopulmonary Resuscitation. ECPR is still be considered a niche therapy, but its relevance and availability are increasing. He is joined by Dr. Adam Green, a practicing intensivist at Cooper University Health Care and an Associate Professor of Medicine at Cooper Medical School of Rowan University (CMSRU). Dr. Green is the director of research for the division of Critical Care and has authored over 50 peer-reviewed publications. He has been part of the ECMO team at Cooper since its inception. Additional resources: Extracorporeal cardiopulmonary resuscitation for refractory cardiac arrest. The Lancet Respiratory Medicine 2025: https://www.sciencedirect.com/science/article/pii/S2213260025001225 Effect of Intra-arrest Transport, Extracorporeal Cardiopulmonary Resuscitation, and Immediate Invasive Assessment and Treatment on Functional Neurologic Outcome in Refractory Out-of-Hospital Cardiac Arrest. JAMA 2022: https://jamanetwork.com/journals/jama/fullarticle/2789313 Association between increasing institutional experience with ECPR and outcomes in patients with out-of-hospital cardiac arrest: A nationwide multicenter observational study in Japan (the JAAM–OHCA registry) RESUSCITATION 2025: https://www.resuscitationjournal.com/article/S0300-9572(24)00862-1/fulltext Early Extracorporeal CPR for Refractory Out-of-Hospital Cardiac Arrest. N Eng J of Med 2023: https://www.nejm.org/doi/full/10.1056/NEJMoa2204511 Books mentioned in this episode: The Perfect Predator: A Scientist's Race to Save Her Husband from a Deadly Superbug. By S. Strathdee and T Patterson: https://amzn.to/3Hxjmez

Robert Yang is a leading expert in digestive wellness, hormone restoration, and performance nutrition with over 27 years of clinical experience. He is an internationally sought-after presenter on a variety of topics on nutrition, gut health, and performance enhancement. He serves as an advisory board member for Titleist Performance Institute, the National Pitching Association, and the USDA's US National Development Program, where he's also the team nutritionist. He consults with elite professional athletes from the XGames, NFL, NHL, MLB, AVP, PGA, LPGA, and European Tour. In this episode of Conversations for Health, we examine the intersection of sports performance and functional nutrition, focusing on both elite and developing athletes. If you work with kids and their parents, you will find this conversation exceptionally valuable. Robert generously shares clinical pearls, information about the labs that he uses with athletes, pre- and post-workout nutrition, traumatic brain injuries, and much more, including the big picture that parents, coaches, and healthcare practitioners need to understand about long-term athletic development for youth athletes.   I'm your host, Evelyne Lambrecht. Thank you for designing a well world with us.   Episode Resources: Robert Yang: robertyang.net Design for Health Resources: Designs for Health - https://www.designsforhealth.com/ Designs for Health Practitioner Exclusive Drug Nutrient Depletion and Interaction Checker - https://www.designsforhealth.com/drug-nutrient-interaction/ Visit the Designs for Health Research and Education Library, which houses medical journals, protocols, webinars, and our blog. https://www.designsforhealth.com/research-and-education/education The Designs for Health Podcast is produced in partnership with Podfly Productions. Chapters: 00:00 Intro. 02:49 Robert Yang's career focuses on sports and performance nutrition and working with elite associations and athletes. 05:54 Key points of long-term athletic development and training for youth.  10:15 Training youth athletes fast throughout growth spurts. 18:07 A foundation of hydration and sodium in training athletes. 24:00 Protein recommendations during training and growth spurts. 29:24 Protein, fat, and fiber for blood sugar control. 30:34 Athletes, GI issues, leaky gut, and inflammation markers. 34:54 Dr. Yang's approach to anti-inflammatories, NSAIDs, and nutrients. 38:33 Lab panels for iron deficiencies and excess storage iron. 41:28 Creatine, amino acid, and other preferred supplements for pre- and post-workout. 49:02 Robert's nutrition strategy and views on intermittent fasting. 56:39 Intra-workout strategies for aging and average patients. 59:25 Post-workout carbohydrates and protein ratio recommendations. 1:04:30 Adaptogens, essential fatty acids, fish oil, and Omega-3 index numbers. 1:10:40 Nutrient recommendations for addressing traumatic brain injuries. 1:17:49 Robert's favorite supplements, favorite health practices, and his changed view on intermittent fasting.

In this week's podcast Dr Arun Dhir, a gastroenterology surgeon, clinical researcher and author of Happy Gut, Healthy Weight, joins Dr Michelle Woolhouse as they delve into the crucial connection between gut health and various chronic conditions, including Gastro-oesophageal reflux disease (GORD) and its links with obesity. 1 in 5 people experience GORD on a weekly basis and in this episode, Dr Arun discusses his algorithm for investigating an individual presenting with GORD. Dr Arun also talks to the challenges of diagnosing conditions like hiatus hernias and the importance of comprehensive investigations, while offering practical advice on improving gut health through diet, stress management, and complementary therapies.  Covered in this episode: (0:46) Welcome Dr Arun Dhir  (2:30) Dr Arun's story  (7:25) “All diseases begin in the gut”  (12:16) Factors causing GORD  (18:17) Hiatus hernia  (21:39) Intra-abdominal pressure  (23:08) Helicobacter pylori  (25:35) Gut testing  (32:09) Gastrocolic reflex  (34:44) Complementary treatment options  (40:02) Low grade gastritis   (43:42) Final remarks  Find today's transcript and show notes here: https://www.bioceuticals.com.au/education/podcasts/gastro-oesophageal-reflux-disease---the-gut-microbiome-as-first-principle Sign up for our monthly newsletter for the latest exclusive clinical tools, articles, and infographics: www.bioceuticals.com.au/signup/ FX DISCLAIMER: The information provided on fx Medicine by BioCeuticals is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.

We're officially back for the 2025-26 Europa & Conference League campaigns, and as always, we're kicking things off with the 3rd qualifying rounds. The 1st legs were full of action, and we discuss some major upsets from old friends (Celje, Víkingur Reykjavík, AEK Larnaca), and new (Hibs, Shelbourne). Then we explore Cyrpus' remarkable European successes of late, why the Irish league is on the rise, if this is a breakout season for Scottish clubs, and speculate whether Malta is the next country to pop their cherry and qualify a team for European group stages for the very first time. We're also introduced to some clubs previously unfamiliar to us, including FC Polissya Zhytomyr, whose name we hopefully did not butchered to unreasonable degree. It feels good to be back – come hang! Cheers Joey O'Brien!

Podcast Summary This episode of the Pain Exam Podcast, hosted by Dr. David Rosenblum, discusses an interesting article about Ketorolac injections for musculoskeletal conditions. The podcast covers: Ketorolac is an NSAID that provides analgesic and anti-inflammatory effects through inhibition of prostaglandin synthesis Multiple studies comparing Ketorolac injections to corticosteroids and hyaluronic acid for various conditions Research shows Ketorolac injections are equally effective as corticosteroids for subacromial conditions, adhesive capsulitis, carpal-metacarpal joint issues, and hip/knee osteoarthritis Ketorolac may be a safer alternative to steroids for certain patients, though it has its own contraindications for those with renal, gastrointestinal, or cardiovascular disease Dr. Rosenblum considers the potential of using Ketorolac injections directly at pain sites rather than intramuscularly Upcoming Courses and Conferences Ultrasound courses in New York and Costa Rica (check unwrappedpain.org) Private ultrasound sessions available Dr. Rosenblum will be speaking at Pain Week about ultrasound in pain practice and PRP Presenting at a primary care conference in London Teaching ultrasound at ISPN LAPSES conference in Chile (Dr. Rosenblum won't attend this year) Ketorolac Injections: An Effective Alternative for Musculoskeletal Pain Management Musculoskeletal conditions such as bursitis, adhesive capsulitis, and osteoarthritis affect millions and often require injectable therapies to reduce pain and inflammation. Traditionally, corticosteroid injections have been the mainstay treatment. However, concerns over side effects like tendon rupture, cartilage damage, and systemic hyperglycemia have prompted exploration of alternatives. A recent narrative review by Kiel et al. (2024) highlights ketorolac—a parenteral nonsteroidal anti-inflammatory drug (NSAID)—as a promising substitute for corticosteroids in musculoskeletal injections. Warning: OFF Label use of Ketorolac discussed. Please consult your physician. See full article  for details. Subacromial Ketorolac Injections for Shoulder Pain Subacromial bursitis and impingement syndrome are common causes of shoulder pain and disability. Several randomized controlled trials have shown that subacromial ketorolac injections provide pain relief and functional improvement comparable to corticosteroids: Goyal et al. demonstrated significant reductions in pain scores after subacromial injection of 60 mg ketorolac versus 40 mg methylprednisolone, with no difference in outcomes between groups. Taheri et al. found similar short-term pain relief at 1 and 3 months with either ketorolac or corticosteroid subacromial injections. Kim et al. reported equivalent clinical improvement in rotator cuff syndrome patients receiving ketorolac or triamcinolone injections. Min et al. noted ketorolac led to better forward flexion and patient satisfaction at 4 weeks compared to corticosteroids. These studies support ketorolac as an effective agent for subacromial injection, offering an alternative for patients where corticosteroid use is limited. Intra-articular Ketorolac Injections for Adhesive Capsulitis and Osteoarthritis Adhesive capsulitis (frozen shoulder) and osteoarthritis of the hip, knee, and carpometacarpal joint are often treated with intra-articular corticosteroids. Ketorolac injections have shown comparable efficacy in these conditions: Akhtar et al. found intra-articular ketorolac significantly reduced shoulder pain at 4 weeks in adhesive capsulitis compared to hyaluronic acid. Ahn et al. reported similar pain relief between intra-articular ketorolac and corticosteroid injections in adhesive capsulitis, with ketorolac providing superior shoulder mobility at 3 and 6 months. Koh et al. showed that adding ketorolac to hyaluronic acid injections in carpometacarpal osteoarthritis resulted in faster onset of pain relief compared to hyaluronic acid alone. Park et al. observed equivalent functional improvements with intra-articular ketorolac or corticosteroids in hip osteoarthritis. Jurgensmeier et al. demonstrated similar symptom improvement at 1 and 3 months post-injection for ketorolac and triamcinolone in hip and knee osteoarthritis. Xu et al. and Bellamy et al. confirmed ketorolac's comparable pain relief and functional benefits to corticosteroids for knee osteoarthritis, with ketorolac being more cost-effective. Lee et al. noted quicker pain reduction with intra-articular ketorolac combined with hyaluronic acid versus hyaluronic acid alone in knee osteoarthritis. aSafety and Pharmacologic Considerations Ketorolac's anti-inflammatory action stems from cyclooxygenase inhibition, reducing prostaglandin synthesis. Its half-life is approximately 5.2–5.6 hours, and it is metabolized in the liver. Unlike corticosteroids, ketorolac avoids systemic hyperglycemia and cartilage damage risks. Animal and in vitro studies suggest ketorolac may protect cartilage by inhibiting inflammatory cytokines. While gastrointestinal, renal, and cardiovascular risks associated with NSAIDs remain considerations, localized intra-articular and subacromial ketorolac injections may limit systemic exposure and adverse effects. Mild, transient post-injection pain has been reported but resolves without intervention. Conclusion Ketorolac injections, administered intra-articularly or subacromially, are a safe, effective, and economical alternative to corticosteroids for managing common musculoskeletal conditions. Their comparable efficacy in reducing pain and improving function, combined with a more favorable side effect profile, makes ketorolac an appealing option for clinicians and patients alike. Further research is warranted to fully elucidate long-term safety and optimal dosing strategies. FAQS Ketorolac Injections for Musculoskeletal Conditions: Frequently Asked Questions Musculoskeletal pain from conditions like bursitis, adhesive capsulitis, and osteoarthritis often requires injectable treatments. Ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), is emerging as a promising alternative to corticosteroids. Below are common questions and answers based on a recent narrative review by Kiel et al. (2024). 1. What is ketorolac and how does it work? Ketorolac is a parenteral NSAID that reduces pain and inflammation by inhibiting cyclooxygenase enzymes, which decreases prostaglandin synthesis. It can be administered orally, intramuscularly, intravenously, or by injection directly into joints or around bursae. 2. How effective is ketorolac for musculoskeletal conditions? Studies show ketorolac injections provide significant pain relief and functional improvement comparable to corticosteroids in conditions like: Subacromial bursitis and shoulder impingement (subacromial injections) Adhesive capsulitis (frozen shoulder) (intra-articular injections) Osteoarthritis of the hip, knee, and thumb carpometacarpal joint (intra-articular injections) 3. What evidence supports subacromial ketorolac injections? Randomized controlled trials found: Goyal et al. and Taheri et al. reported similar pain reduction and functional outcomes between ketorolac and corticosteroids for subacromial injections. Kim et al. and Min et al. observed comparable or better patient satisfaction and shoulder mobility with ketorolac versus corticosteroids. 4. How does intra-articular ketorolac compare to corticosteroids for adhesive capsulitis? Akhtar et al. showed ketorolac reduced shoulder pain more than hyaluronic acid. Ahn et al. found ketorolac and corticosteroids equally effective for pain relief, with ketorolac providing better shoulder mobility at 3 and 6 months. 5. What about ketorolac for osteoarthritis? Ketorolac combined with hyaluronic acid provided faster pain relief than hyaluronic acid alone in thumb carpometacarpal joint osteoarthritis (Koh et al.). Intra-articular ketorolac had similar efficacy to corticosteroids in hip (Park et al., Jurgensmeier et al.) and knee osteoarthritis (Bellamy et al., Xu et al.). Ketorolac injections were more cost-effective compared to corticosteroids (Bellamy et al.). 6. Are ketorolac injections safe? Ketorolac's side effects are similar to other NSAIDs, mainly involving gastrointestinal, renal, and cardiovascular risks. However, localized intra-articular and subacromial injections may reduce systemic exposure. Animal studies suggest ketorolac does not harm cartilage and may protect against inflammatory damage. Mild, transient local pain post-injection is possible but usually resolves without treatment. 7. What are the limitations of ketorolac use? Ketorolac is not suitable for patients with: Renal impairment Gastrointestinal ulcers or bleeding risk Cardiovascular disease or hypertension NSAID hypersensitivity, especially in asthma or chronic urticaria patients Clinicians should assess individual risks before choosing ketorolac injections. 8. How does ketorolac's pharmacokinetics affect its use? Ketorolac has a plasma half-life of about 5.2 to 5.6 hours and is metabolized in the liver. Pharmacokinetics for subcutaneous or intra-articular administration are less defined but systemic absorption occurs. Its relatively short half-life supports repeated dosing if needed. 9. Why consider ketorolac over corticosteroids? Ketorolac avoids corticosteroid-associated risks such as tendon rupture, cartilage damage, and steroid-induced hyperglycemia. It is also more cost-effective, making it a favorable option for patients and healthcare systems. 10. What further research is needed? More large-scale, long-term studies are needed to fully understand ketorolac's intra-articular effects, optimal dosing, and safety profile compared to corticosteroids and other treatments. Summary: Ketorolac injections, whether intra-articular or subacromial, offer a safe, effective, and economical alternative to corticosteroids for managing various musculoskeletal conditions. This makes ketorolac an important option in pain management and inflammation control.     Reference: Kiel J, Applewhite AI, Bertasi TGO, Bertasi RAO, Seemann LL, Costa LMC, Helmi H, Pujalte GGA. Ketorolac Injections for Musculoskeletal Conditions: A Narrative Review. Clinical Medicine & Research. 2024;22(1):19-27. DOI: https://doi.org/10.3121/cmr.2024.1847 Disclaimer: This Podcast, website and any content from NRAP Academy (PMRexam.com) otherwise known as Qbazaar.com, LLC is  for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. Professionals should conduct their own fact finding, research, and due diligence to come to their own conclusions for treating patients. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.    

Podcast Summary This episode of the Pain Exam Podcast, hosted by Dr. David Rosenblum, discusses an interesting article about Ketorolac injections for musculoskeletal conditions. The podcast covers: Ketorolac is an NSAID that provides analgesic and anti-inflammatory effects through inhibition of prostaglandin synthesis Multiple studies comparing Ketorolac injections to corticosteroids and hyaluronic acid for various conditions Research shows Ketorolac injections are equally effective as corticosteroids for subacromial conditions, adhesive capsulitis, carpal-metacarpal joint issues, and hip/knee osteoarthritis Ketorolac may be a safer alternative to steroids for certain patients, though it has its own contraindications for those with renal, gastrointestinal, or cardiovascular disease Dr. Rosenblum considers the potential of using Ketorolac injections directly at pain sites rather than intramuscularly Upcoming Courses and Conferences Ultrasound courses in New York and Costa Rica (check unwrappedpain.org) Private ultrasound sessions available Dr. Rosenblum will be speaking at Pain Week about ultrasound in pain practice and PRP Presenting at a primary care conference in London Teaching ultrasound at ISPN LAPS  conference in Chile (Dr. Rosenblum won't attend this year) Ketorolac Injections: An Effective Alternative for Musculoskeletal Pain Management Musculoskeletal conditions such as bursitis, adhesive capsulitis, and osteoarthritis affect millions and often require injectable therapies to reduce pain and inflammation. Traditionally, corticosteroid injections have been the mainstay treatment. However, concerns over side effects like tendon rupture, cartilage damage, and systemic hyperglycemia have prompted exploration of alternatives. A recent narrative review by Kiel et al. (2024) highlights ketorolac—a parenteral nonsteroidal anti-inflammatory drug (NSAID)—as a promising substitute for corticosteroids in musculoskeletal injections. Warning: OFF Label use of Ketorolac discussed. Please consult your physician. See full article  for details. Subacromial Ketorolac Injections for Shoulder Pain Subacromial bursitis and impingement syndrome are common causes of shoulder pain and disability. Several randomized controlled trials have shown that subacromial ketorolac injections provide pain relief and functional improvement comparable to corticosteroids: Goyal et al. demonstrated significant reductions in pain scores after subacromial injection of 60 mg ketorolac versus 40 mg methylprednisolone, with no difference in outcomes between groups. Taheri et al. found similar short-term pain relief at 1 and 3 months with either ketorolac or corticosteroid subacromial injections. Kim et al. reported equivalent clinical improvement in rotator cuff syndrome patients receiving ketorolac or triamcinolone injections. Min et al. noted ketorolac led to better forward flexion and patient satisfaction at 4 weeks compared to corticosteroids. These studies support ketorolac as an effective agent for subacromial injection, offering an alternative for patients where corticosteroid use is limited. Intra-articular Ketorolac Injections for Adhesive Capsulitis and Osteoarthritis Adhesive capsulitis (frozen shoulder) and osteoarthritis of the hip, knee, and carpometacarpal joint are often treated with intra-articular corticosteroids. Ketorolac injections have shown comparable efficacy in these conditions: Akhtar et al. found intra-articular ketorolac significantly reduced shoulder pain at 4 weeks in adhesive capsulitis compared to hyaluronic acid. Ahn et al. reported similar pain relief between intra-articular ketorolac and corticosteroid injections in adhesive capsulitis, with ketorolac providing superior shoulder mobility at 3 and 6 months. Koh et al. showed that adding ketorolac to hyaluronic acid injections in carpometacarpal osteoarthritis resulted in faster onset of pain relief compared to hyaluronic acid alone. Park et al. observed equivalent functional improvements with intra-articular ketorolac or corticosteroids in hip osteoarthritis. Jurgensmeier et al. demonstrated similar symptom improvement at 1 and 3 months post-injection for ketorolac and triamcinolone in hip and knee osteoarthritis. Xu et al. and Bellamy et al. confirmed ketorolac's comparable pain relief and functional benefits to corticosteroids for knee osteoarthritis, with ketorolac being more cost-effective. Lee et al. noted quicker pain reduction with intra-articular ketorolac combined with hyaluronic acid versus hyaluronic acid alone in knee osteoarthritis. aSafety and Pharmacologic Considerations Ketorolac's anti-inflammatory action stems from cyclooxygenase inhibition, reducing prostaglandin synthesis. Its half-life is approximately 5.2–5.6 hours, and it is metabolized in the liver. Unlike corticosteroids, ketorolac avoids systemic hyperglycemia and cartilage damage risks. Animal and in vitro studies suggest ketorolac may protect cartilage by inhibiting inflammatory cytokines. While gastrointestinal, renal, and cardiovascular risks associated with NSAIDs remain considerations, localized intra-articular and subacromial ketorolac injections may limit systemic exposure and adverse effects. Mild, transient post-injection pain has been reported but resolves without intervention. Conclusion Ketorolac injections, administered intra-articularly or subacromially, are a safe, effective, and economical alternative to corticosteroids for managing common musculoskeletal conditions. Their comparable efficacy in reducing pain and improving function, combined with a more favorable side effect profile, makes ketorolac an appealing option for clinicians and patients alike. Further research is warranted to fully elucidate long-term safety and optimal dosing strategies. FAQS Ketorolac Injections for Musculoskeletal Conditions: Frequently Asked Questions Musculoskeletal pain from conditions like bursitis, adhesive capsulitis, and osteoarthritis often requires injectable treatments. Ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), is emerging as a promising alternative to corticosteroids. Below are common questions and answers based on a recent narrative review by Kiel et al. (2024). 1. What is ketorolac and how does it work? Ketorolac is a parenteral NSAID that reduces pain and inflammation by inhibiting cyclooxygenase enzymes, which decreases prostaglandin synthesis. It can be administered orally, intramuscularly, intravenously, or by injection directly into joints or around bursae. 2. How effective is ketorolac for musculoskeletal conditions? Studies show ketorolac injections provide significant pain relief and functional improvement comparable to corticosteroids in conditions like: Subacromial bursitis and shoulder impingement (subacromial injections) Adhesive capsulitis (frozen shoulder) (intra-articular injections) Osteoarthritis of the hip, knee, and thumb carpometacarpal joint (intra-articular injections) 3. What evidence supports subacromial ketorolac injections? Randomized controlled trials found: Goyal et al. and Taheri et al. reported similar pain reduction and functional outcomes between ketorolac and corticosteroids for subacromial injections. Kim et al. and Min et al. observed comparable or better patient satisfaction and shoulder mobility with ketorolac versus corticosteroids. 4. How does intra-articular ketorolac compare to corticosteroids for adhesive capsulitis? Akhtar et al. showed ketorolac reduced shoulder pain more than hyaluronic acid. Ahn et al. found ketorolac and corticosteroids equally effective for pain relief, with ketorolac providing better shoulder mobility at 3 and 6 months. 5. What about ketorolac for osteoarthritis? Ketorolac combined with hyaluronic acid provided faster pain relief than hyaluronic acid alone in thumb carpometacarpal joint osteoarthritis (Koh et al.). Intra-articular ketorolac had similar efficacy to corticosteroids in hip (Park et al., Jurgensmeier et al.) and knee osteoarthritis (Bellamy et al., Xu et al.). Ketorolac injections were more cost-effective compared to corticosteroids (Bellamy et al.). 6. Are ketorolac injections safe? Ketorolac's side effects are similar to other NSAIDs, mainly involving gastrointestinal, renal, and cardiovascular risks. However, localized intra-articular and subacromial injections may reduce systemic exposure. Animal studies suggest ketorolac does not harm cartilage and may protect against inflammatory damage. Mild, transient local pain post-injection is possible but usually resolves without treatment. 7. What are the limitations of ketorolac use? Ketorolac is not suitable for patients with: Renal impairment Gastrointestinal ulcers or bleeding risk Cardiovascular disease or hypertension NSAID hypersensitivity, especially in asthma or chronic urticaria patients Clinicians should assess individual risks before choosing ketorolac injections. 8. How does ketorolac's pharmacokinetics affect its use? Ketorolac has a plasma half-life of about 5.2 to 5.6 hours and is metabolized in the liver. Pharmacokinetics for subcutaneous or intra-articular administration are less defined but systemic absorption occurs. Its relatively short half-life supports repeated dosing if needed. 9. Why consider ketorolac over corticosteroids? Ketorolac avoids corticosteroid-associated risks such as tendon rupture, cartilage damage, and steroid-induced hyperglycemia. It is also more cost-effective, making it a favorable option for patients and healthcare systems. 10. What further research is needed? More large-scale, long-term studies are needed to fully understand ketorolac's intra-articular effects, optimal dosing, and safety profile compared to corticosteroids and other treatments. Summary: Ketorolac injections, whether intra-articular or subacromial, offer a safe, effective, and economical alternative to corticosteroids for managing various musculoskeletal conditions. This makes ketorolac an important option in pain management and inflammation control.     Reference: Kiel J, Applewhite AI, Bertasi TGO, Bertasi RAO, Seemann LL, Costa LMC, Helmi H, Pujalte GGA. Ketorolac Injections for Musculoskeletal Conditions: A Narrative Review. Clinical Medicine & Research. 2024;22(1):19-27. DOI: https://doi.org/10.3121/cmr.2024.1847 Disclaimer: This Podcast, website and any content from NRAP Academy (PMRexam.com) otherwise known as Qbazaar.com, LLC is  for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. Professionals should conduct their own fact finding, research, and due diligence to come to their own conclusions for treating patients. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.  

Podcast Summary This episode of the Pain Exam Podcast, hosted by Dr. David Rosenblum, discusses an interesting article about Ketorolac injections for musculoskeletal conditions. The podcast covers: Ketorolac is an NSAID that provides analgesic and anti-inflammatory effects through inhibition of prostaglandin synthesis Multiple studies comparing Ketorolac injections to corticosteroids and hyaluronic acid for various conditions Research shows Ketorolac injections are equally effective as corticosteroids for subacromial conditions, adhesive capsulitis, carpal-metacarpal joint issues, and hip/knee osteoarthritis Ketorolac may be a safer alternative to steroids for certain patients, though it has its own contraindications for those with renal, gastrointestinal, or cardiovascular disease Dr. Rosenblum considers the potential of using Ketorolac injections directly at pain sites rather than intramuscularly Upcoming Courses and Conferences Ultrasound courses in New York and Costa Rica (check unwrappedpain.org) Private ultrasound sessions available Dr. Rosenblum will be speaking at Pain Week about ultrasound in pain practice and PRP Presenting at a primary care conference in London Teaching ultrasound at ISPN LAPSES conference in Chile (Dr. Rosenblum won't attend this year) Ketorolac Injections: An Effective Alternative for Musculoskeletal Pain Management Musculoskeletal conditions such as bursitis, adhesive capsulitis, and osteoarthritis affect millions and often require injectable therapies to reduce pain and inflammation. Traditionally, corticosteroid injections have been the mainstay treatment. However, concerns over side effects like tendon rupture, cartilage damage, and systemic hyperglycemia have prompted exploration of alternatives. A recent narrative review by Kiel et al. (2024) highlights ketorolac—a parenteral nonsteroidal anti-inflammatory drug (NSAID)—as a promising substitute for corticosteroids in musculoskeletal injections. Warning: OFF Label use of Ketorolac discussed. Please consult your physician. See full article  for details. Subacromial Ketorolac Injections for Shoulder Pain Subacromial bursitis and impingement syndrome are common causes of shoulder pain and disability. Several randomized controlled trials have shown that subacromial ketorolac injections provide pain relief and functional improvement comparable to corticosteroids: Goyal et al. demonstrated significant reductions in pain scores after subacromial injection of 60 mg ketorolac versus 40 mg methylprednisolone, with no difference in outcomes between groups. Taheri et al. found similar short-term pain relief at 1 and 3 months with either ketorolac or corticosteroid subacromial injections. Kim et al. reported equivalent clinical improvement in rotator cuff syndrome patients receiving ketorolac or triamcinolone injections. Min et al. noted ketorolac led to better forward flexion and patient satisfaction at 4 weeks compared to corticosteroids. These studies support ketorolac as an effective agent for subacromial injection, offering an alternative for patients where corticosteroid use is limited. Intra-articular Ketorolac Injections for Adhesive Capsulitis and Osteoarthritis Adhesive capsulitis (frozen shoulder) and osteoarthritis of the hip, knee, and carpometacarpal joint are often treated with intra-articular corticosteroids. Ketorolac injections have shown comparable efficacy in these conditions: Akhtar et al. found intra-articular ketorolac significantly reduced shoulder pain at 4 weeks in adhesive capsulitis compared to hyaluronic acid. Ahn et al. reported similar pain relief between intra-articular ketorolac and corticosteroid injections in adhesive capsulitis, with ketorolac providing superior shoulder mobility at 3 and 6 months. Koh et al. showed that adding ketorolac to hyaluronic acid injections in carpometacarpal osteoarthritis resulted in faster onset of pain relief compared to hyaluronic acid alone. Park et al. observed equivalent functional improvements with intra-articular ketorolac or corticosteroids in hip osteoarthritis. Jurgensmeier et al. demonstrated similar symptom improvement at 1 and 3 months post-injection for ketorolac and triamcinolone in hip and knee osteoarthritis. Xu et al. and Bellamy et al. confirmed ketorolac's comparable pain relief and functional benefits to corticosteroids for knee osteoarthritis, with ketorolac being more cost-effective. Lee et al. noted quicker pain reduction with intra-articular ketorolac combined with hyaluronic acid versus hyaluronic acid alone in knee osteoarthritis. aSafety and Pharmacologic Considerations Ketorolac's anti-inflammatory action stems from cyclooxygenase inhibition, reducing prostaglandin synthesis. Its half-life is approximately 5.2–5.6 hours, and it is metabolized in the liver. Unlike corticosteroids, ketorolac avoids systemic hyperglycemia and cartilage damage risks. Animal and in vitro studies suggest ketorolac may protect cartilage by inhibiting inflammatory cytokines. While gastrointestinal, renal, and cardiovascular risks associated with NSAIDs remain considerations, localized intra-articular and subacromial ketorolac injections may limit systemic exposure and adverse effects. Mild, transient post-injection pain has been reported but resolves without intervention. Conclusion Ketorolac injections, administered intra-articularly or subacromially, are a safe, effective, and economical alternative to corticosteroids for managing common musculoskeletal conditions. Their comparable efficacy in reducing pain and improving function, combined with a more favorable side effect profile, makes ketorolac an appealing option for clinicians and patients alike. Further research is warranted to fully elucidate long-term safety and optimal dosing strategies. FAQS Ketorolac Injections for Musculoskeletal Conditions: Frequently Asked Questions Musculoskeletal pain from conditions like bursitis, adhesive capsulitis, and osteoarthritis often requires injectable treatments. Ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), is emerging as a promising alternative to corticosteroids. Below are common questions and answers based on a recent narrative review by Kiel et al. (2024). 1. What is ketorolac and how does it work? Ketorolac is a parenteral NSAID that reduces pain and inflammation by inhibiting cyclooxygenase enzymes, which decreases prostaglandin synthesis. It can be administered orally, intramuscularly, intravenously, or by injection directly into joints or around bursae. 2. How effective is ketorolac for musculoskeletal conditions? Studies show ketorolac injections provide significant pain relief and functional improvement comparable to corticosteroids in conditions like: Subacromial bursitis and shoulder impingement (subacromial injections) Adhesive capsulitis (frozen shoulder) (intra-articular injections) Osteoarthritis of the hip, knee, and thumb carpometacarpal joint (intra-articular injections) 3. What evidence supports subacromial ketorolac injections? Randomized controlled trials found: Goyal et al. and Taheri et al. reported similar pain reduction and functional outcomes between ketorolac and corticosteroids for subacromial injections. Kim et al. and Min et al. observed comparable or better patient satisfaction and shoulder mobility with ketorolac versus corticosteroids. 4. How does intra-articular ketorolac compare to corticosteroids for adhesive capsulitis? Akhtar et al. showed ketorolac reduced shoulder pain more than hyaluronic acid. Ahn et al. found ketorolac and corticosteroids equally effective for pain relief, with ketorolac providing better shoulder mobility at 3 and 6 months. 5. What about ketorolac for osteoarthritis? Ketorolac combined with hyaluronic acid provided faster pain relief than hyaluronic acid alone in thumb carpometacarpal joint osteoarthritis (Koh et al.). Intra-articular ketorolac had similar efficacy to corticosteroids in hip (Park et al., Jurgensmeier et al.) and knee osteoarthritis (Bellamy et al., Xu et al.). Ketorolac injections were more cost-effective compared to corticosteroids (Bellamy et al.). 6. Are ketorolac injections safe? Ketorolac's side effects are similar to other NSAIDs, mainly involving gastrointestinal, renal, and cardiovascular risks. However, localized intra-articular and subacromial injections may reduce systemic exposure. Animal studies suggest ketorolac does not harm cartilage and may protect against inflammatory damage. Mild, transient local pain post-injection is possible but usually resolves without treatment. 7. What are the limitations of ketorolac use? Ketorolac is not suitable for patients with: Renal impairment Gastrointestinal ulcers or bleeding risk Cardiovascular disease or hypertension NSAID hypersensitivity, especially in asthma or chronic urticaria patients Clinicians should assess individual risks before choosing ketorolac injections. 8. How does ketorolac's pharmacokinetics affect its use? Ketorolac has a plasma half-life of about 5.2 to 5.6 hours and is metabolized in the liver. Pharmacokinetics for subcutaneous or intra-articular administration are less defined but systemic absorption occurs. Its relatively short half-life supports repeated dosing if needed. 9. Why consider ketorolac over corticosteroids? Ketorolac avoids corticosteroid-associated risks such as tendon rupture, cartilage damage, and steroid-induced hyperglycemia. It is also more cost-effective, making it a favorable option for patients and healthcare systems. 10. What further research is needed? More large-scale, long-term studies are needed to fully understand ketorolac's intra-articular effects, optimal dosing, and safety profile compared to corticosteroids and other treatments. Summary: Ketorolac injections, whether intra-articular or subacromial, offer a safe, effective, and economical alternative to corticosteroids for managing various musculoskeletal conditions. This makes ketorolac an important option in pain management and inflammation control.     Reference: Kiel J, Applewhite AI, Bertasi TGO, Bertasi RAO, Seemann LL, Costa LMC, Helmi H, Pujalte GGA. Ketorolac Injections for Musculoskeletal Conditions: A Narrative Review. Clinical Medicine & Research. 2024;22(1):19-27. DOI: https://doi.org/10.3121/cmr.2024.1847 Disclaimer: This Podcast, website and any content from NRAP Academy (PMRexam.com) otherwise known as Qbazaar.com, LLC is  for general informational purposes only and does not constitute the practice of medicine, nursing or other professional health care services, including the giving of medical advice, and no doctor/patient relationship is formed. The use of information on this podcast or materials linked from this podcast is at the user's own risk. Professionals should conduct their own fact finding, research, and due diligence to come to their own conclusions for treating patients. The content of this podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Users should not disregard or delay in obtaining medical advice for any medical condition they may have and should seek the assistance of their health care professionals for any such conditions.    

South Korea’s president, Lee Jae Myung, orders the removal of loudspeakers to reduce tension with Pyongyang. Plus: Witkoff in Moscow, luxury earnings takeaways and a musical round-up with Matt Wolf. See omnystudio.com/listener for privacy information.

Canada Immigration LMIA-Exempt Work Permit figures for C61,  (Intra-company transferees starting a branch or affiliate in Canada) in  2023, for Total visas issued by IRCC.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration Practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  In 2023, a total of  245 LMIA-Exempt Work Permits were issued by IRCC, under C61, (Intra-company transferees starting a branch or affiliate in Canada) If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant 

 Canada Immigration LMIA-Exempt Work Permit figures for C61, (Intra-company transferees starting a branch or affiliate in Canada) in 2023 for the province/territory of Alberta.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  The Province or Territory of Alberta accepted 10 LMIA-Exempt Work Permits in 2023, under C61, (Intra-company transferees starting a branch or affiliate in Canada).Stay informed about past events in Alberta by visiting this link: https://myar.me/tag/ab If you are interested in gaining comprehensive insights into the Federal Canadian Experience Class or other Canadian Federal or Provincial Immigration programs, or if you need guidance post-selection, we cordially invite you to connect with us via https://myar.me/c. We highly recommend attending our complimentary Zoom resource meetings held every Thursday. We kindly request you to thoroughly review the available resources. Subsequently, if you have any questions, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session on Fridays. You can find details for both these meetings at https://myar.me/zoom.  Our dedicated team is committed to providing professional assistance throughout your immigration journey. Furthermore, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant 

Canada Immigration LMIA-Exempt Work Permit figures for C16, (Intra-Company Transferee Francophone mobility s) in 2023 for the province/territory of British Columbia.   Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, OntarioThe Province or Territory of British Columbia accepted 235 LMIA-Exempt Work Permits in 2023, under C16, (Intra-Company Transferee Francophone mobility s).To delve into the history of news in British Columbia, follow this link: https://myar.me/tag/bcIf you have an interest in gaining comprehensive insights into the Canadian Federal Spouses and Partners sponsorship program or other Canadian Federal or Provincial Immigration programs, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.

Canada Immigration LMIA-Exempt Work Permit figures for C16, (Intra-Company Transferee Francophone mobility) in 2023 for the province/territory of Saskatchewan. Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, OntarioThe Province or Territory of Saskatchewan accepted 15 LMIA-Exempt Work Permits in 2023, under C16, (Intra-Company Transferee Francophone mobility).Discover past news items from Saskatchewan by clicking on this link: https://myar.me/tag/skShould you be interested in gaining comprehensive insights into the Federal Atlantic Immigration Program (AIP) or other Canadian Federal or Provincial Immigration programs, or if you require guidance after selection, we warmly invite you to connect with us via https://myar.me/c. We highly recommend attending our complimentary Zoom resource meetings held every Thursday. We kindly ask you to carefully review the available resources. In case you have any inquiries, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can access details for both of these meetings at https://myar.me/zoom. Our dedicated team is committed to providing professional assistance throughout your immigration journey. Furthermore, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.

Canada Immigration LMIA-Exempt Work Permit figures for C16,  (Intra-Company Transferee Francophone mobility) in  2022, for Total visas issued by IRCC.Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  In 2022, a total of  875 LMIA-Exempt Work Permits were issued by IRCC, under C16, (Intra-Company Transferee Francophone mobility).   If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant

Canada Immigration LMIA-Exempt Work Permit figures for C16,  (Intra-Company Transferee Francophone mobility) in  2021, for Total visas issued by IRCC.Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  In 2021, a total of  235 LMIA-Exempt Work Permits were issued by IRCC, under C16, (Intra-Company Transferee Francophone mobility).   If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant

Canada Immigration LMIA-Exempt Work Permit figures for C16, (Intra-Company Transferee Francophone mobility) in  2023, for Total visas issued by IRCC.Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, Ontario  In 2023, a total of 1320 LMIA-Exempt Work Permits were issued by IRCC, under C16, (Intra-Company Transferee Francophone mobility).  If you have an interest in gaining assistance with Work Permits based on your country of Citizenship, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant 

Canada Immigration LMIA-Exempt Work Permit figures for C16, (Intra-Company Transferee Francophone mobility) in 2023 for the province/territory of Quebec.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, OntarioThe Province or Territory of Quebec accepted 5 LMIA-Exempt Work Permits in 2023, under C16, (Intra-Company Transferee Francophone mobility) Access archived news articles from Quebec via this link: https://myar.me/tag/qcIf you are interested in gaining comprehensive insights into the Federal Startup Business Program or other Canadian Federal or Provincial Immigration programs, or if you need guidance post-selection, we cordially invite you to connect with us via https://myar.me/c. We highly recommend attending our complimentary Zoom resource meetings held every Thursday. We kindly request you to thoroughly review the available resources. Subsequently, if you have any questions, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session on Fridays. You can find details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing professional assistance throughout your immigration journey. Furthermore, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant

Canada Immigration LMIA-Exempt Work Permit figures for C16, (Intra-Company Transferee Francophone mobility) in 2023 for the province/territory of Ontario. Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, OntarioThe Province or Territory of Ontario accepted 340 LMIA-Exempt Work Permits in 2023, under C16, (Intra-Company Transferee Francophone mobility).Dive into the archives of news from the Province of Ontario through this link: https://myar.me/tag/onIf you are interested in gaining comprehensive insights into the Quebec Investor Program or other Canadian Federal or Provincial Immigration programs, or if you require guidance after selection, we warmly invite you to connect with us via https://myar.me/c. We strongly encourage you to participate in our complimentary Zoom resource meetings held every Thursday. We kindly ask you to carefully review the available resources. If you have any questions, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session on Fridays. You can find details for both meetings at https://myar.me/zoom. Our dedicated team is committed to offering professional assistance throughout your immigration journey. In addition, IRCNews provides valuable insights on selecting a qualified representative to advocate for you with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.

Canada Immigration LMIA-Exempt Work Permit figures for C16, (Intra-Company Transferee Francophone mobility s) in 2023 for the province/territory of Northwest Territories.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, OntarioThe Province or Territory of Northwest Territories accepted 10 LMIA-Exempt Work Permits in 2023, under C16, (Intra-Company Transferee Francophone mobility s).Explore past news stories from North West Territories using the following link: https://myar.me/tag/nt If you have an interest in gaining comprehensive insights into the Federal Self Employed program or other Canadian Federal or Provincial Immigration programs, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant. 

Canada Immigration LMIA-Exempt Work Permit figures for C16, (Intra-Company Transferee Francophone mobility) in 2023 for the province/territory of New Brunswick.  Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, OntarioThe Province or Territory of New Brunswick accepted 265 LMIA-Exempt Work Permits in 2023, under C16, (Intra-Company Transferee Francophone mobility).Stay updated with past news in New Brunswick by visiting this link: https://myar.me/tag/nb/. If you have an interest in acquiring comprehensive insights into the Federal RNIP or Rural and Northern Immigration Pilot program or other Canadian Federal or Provincial Immigration programs, or if you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We highly recommend your attendance at our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Should any queries arise subsequently, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing professional assistance throughout your immigration process. In addition, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant.

Canada Immigration LMIA-Exempt Work Permit figures for C16, (Intra-Company Transferee Francophone mobility) in 2023 for the province/territory of Manitoba.   Good day ladies and gentlemen, this is IRC news, and I am Joy Stephen, an authorized Canadian Immigration practitioner bringing out this Canada Work Permit application data specific to LMIA work permits or employer driven work permits or LMIA exempt work permits for multiple years based on your country of Citizenship. I am coming to you from the Polinsys studios in Cambridge, OntarioThe Province or Territory of Manitoba accepted 60 LMIA-Exempt Work Permits in 2023, under C16, (Intra-Company Transferee Francophone mobility).To delve into the history of news in Manitoba, follow this link: https://myar.me/tag/mbIf you have an interest in gaining comprehensive insights into the Canadian Federal Spouses and Partners sponsorship program or other Canadian Federal or Provincial Immigration programs, or should you require guidance post-selection, we extend a warm invitation to connect with us via https://myar.me/c. We strongly recommend attending our complimentary Zoom resource meetings conducted every Thursday. We kindly request you to carefully review the available resources. Subsequently, should any queries arise, our team of Canadian Authorized Representatives is readily available to address your concerns during the weekly AR's Q&A session held on Fridays. You can find the details for both these meetings at https://myar.me/zoom. Our dedicated team is committed to providing you with professional assistance in navigating the immigration process. Additionally, IRCNews offers valuable insights on selecting a qualified representative to advocate on your behalf with the Canadian Federal or Provincial governments, accessible at https://ircnews.ca/consultant. 

In this episode of The Litigation Psychology Podcast, Bill Kanasky, Jr., Ph.D. dives into the rapidly evolving world of plaintiff attorney advertising and specifically how it's exploded on social media. While traditional ads like billboards and cheesy daytime TV spots are still around, many plaintiff firms are now taking a totally different approach online. Bill explains how these firms are using TikTok, Instagram, and X (formally Twitter) to push out videos that aren't focused on big verdicts or settlements, but rather aimed at shaping public opinion and, ultimately, juror attitudes. Bill breaks these videos down into five key themes: 1. Anti-insurance messaging, where attorneys warn viewers not to speak with or accept offers from insurance companies because “they'll screw you”; 2. Humanization of the plaintiff firm, posting behind-the-scenes office tours, staff intros, and even lighthearted content like dance videos and trivia to show they're just regular, likable people; 3. Educational content, where attorneys explain litigation terms and legal processes in simple, friendly language; 4. Do's and don'ts videos, like checklists for what to do if you're injured or filing a claim; 5. Intra-plaintiff firm competition, where attorneys differentiate themselves by claiming superior trial skills over “billboard lawyers.” Bill notes that what's most interesting is that these videos and messages are rarely about huge payouts but instead they're about fairness, trust, and credibility. And it's working. Plaintiff attorneys continue to build successful practices and jurors see these videos, and consciously or not, they come into the courtroom with biases that can be hard to shake. Bill points out that the defense bar and insurance industry are completely missing from this space, leaving the messaging one-sided. Lastly, Bill asks the questions: should the defense start countering this? And should voir dire include questions about social media exposure to these types of messages? 

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The Space Show hosted a discussion with Dr. Saralyn Mark, focusing on space medicine, human spaceflight, and the challenges of long-duration space travel. The conversation covered topics such as the impact of space on human health, advancements in space technology, and the potential for space research to benefit medical treatments on Earth. Dr. Mark emphasized the importance of international collaboration, ethical considerations, and continued funding for space exploration to address challenges and unlock new possibilities for human health and space colonization.Dr. Saralyn Mark was welcomed to the Space Show. We began by highlighting her extensive background in medicine and space exploration. Dr. Mark shared her journey from childhood dreams of becoming an astronaut to pursuing a medical career, eventually combining both passions through her work with NASA and her private company, Solamed Solutions. They discussed the challenges she faced as a woman in medicine and space, emphasizing the importance of women in these fields. The conversation also touched on the impact of space travel on human health, particularly in relation to osteoporosis research.David and Sara discussed the advancements and challenges in space medicine, highlighting the integration of space technology into everyday life and the need for public education about space benefits. Dr. Saralyn emphasized the progress made in keeping astronauts healthy in space, despite the risks, and predicted further advancements with precision innovation. They also discussed the relevance of space medicine to human health on Earth, with Dr. Saralyn noting that space provides a unique platform for understanding and addressing health issues on both fronts.Our guest discussed the challenges and ethical considerations of sending children into space, highlighting the risks and the need for further research on the effects of space travel on human development. She emphasized the importance of developing technologies and protocols not only for current astronauts but also for future generations who may travel to other planets. She also addressed concerns about children's health today, noting issues such as type 2 diabetes, obesity, and the impact of fast food on health, as well as the emerging problem of long Covid, which can lead to chronic conditions affecting multiple body systems.We both talked about the importance of space research in understanding human biology and potential treatments, highlighting how space can serve as a platform for studying the immune system, aging, and medication effects. She emphasized that cutting funding for space research would hinder future discoveries and advancements. The conversation touched on the need for tailored countermeasures to reverse aging effects observed in space and the importance of continued research funding.In addition, the discussion focused on the challenges and opportunities of space colonization, particularly on Mars with its 38% Earth gravity. Dr. Saralyn explained that while we have data on microgravity and Earth gravity, we need specialized facilities to study partial gravity effects on human health, with new labs being developed near Orlando and other locations. She outlined three verticals for her company Soloman Solutions: consultancy, education through space explorer summits, and operational medicine to support space missions. David raised questions about the commercial space industry's role and the potential for 3D printing and tissue replication in space to lead to medical breakthroughs on Earth, to which she responded that while these technologies are promising for the future, they are not likely to become mainstream anytime soon.Dr. Mark discussed the importance of nutrition in space, highlighting that while it's crucial for both mental and physical health, space environments present unique challenges such as irradiation of food and changes in smell and taste due to fluid shifts. She explained that astronauts need to exercise 2-2.5 hours daily to maintain muscle and bone mass, and commercial space programs like Starlab are partnering with companies like Hilton to develop food solutions that are both nutritious on Earth and space compatible. Dr. Saralyn noted that while astronauts typically regain their sense of smell and taste upon returning to Earth, maintaining a balanced diet in space requires careful consideration of cultural preferences and the need for enjoyable meals.Near the end of the program, we both talked about the feasibility and challenges of sending humans to Mars, including the need for international collaboration, technological advancements, and ethical considerations around gene modification for space travel. They explored the potential benefits and risks of modifying human genes to enhance health in space, emphasizing the importance of careful regulation and ethical oversight. Sara mentioned ongoing efforts to simulate space environments on Earth and the psychological challenges of long-duration space travel, such as isolation and delays in communication. They also addressed the question of gender differences in space adaptation, noting that while women may have certain advantages, diversity in crew composition leads to better team dynamics and outcomes.In response to a listener question, Sara discussed the potential of hibernation-like states for long-duration space travel, highlighting ongoing research and challenges such as waking up and preventing cellular damage. She also addressed the impact of solar and galactic radiation on space missions, suggesting solutions like better shelters and nutraceuticals to protect astronauts. Ajay raised concerns about simulating partial gravity on Earth, and Dr. Saralyn mentioned new technologies being developed for this purpose. The discussion concluded with our guest emphasizing the need for global collaboration in space exploration and her hope to see a united effort to thrive on and beyond Earth.Special thanks to our sponsors:Northrup Grumman, American Institute of Aeronautics and Astronautics, Helix Space in Luxembourg, Celestis Memorial Spaceflights, Astrox Corporation, Dr. Haym Benaroya of Rutgers University, The Space Settlement Progress Blog by John Jossy, The Atlantis Project, and Artless EntertainmentOur Toll Free Line for Live Broadcasts: 1-866-687-7223For real time program participation, email Dr. Space at: drspace@thespaceshow.comThe Space Show is a non-profit 501C3 through its parent, One Giant Leap Foundation, Inc. To donate via Pay Pal, use:To donate with Zelle, use the email address: david@onegiantleapfoundation.org.If you prefer donating with a check, please make the check payable to One Giant Leap Foundation and mail to:One Giant Leap Foundation, 11035 Lavender Hill Drive Ste. 160-306 Las Vegas, NV 89135Upcoming Programs:Broadcast 4388: Sunday, June 22: 12 PM PDT; Dr. Karen Lloyd re her book “Intra-terrestrials: Discovering the Strangest Life on Earth”Broadcast 4389: Dr. Karen Lloyd | Sunday 22 Jun 2025 1200PM PTGuests: Dr. Karen LloydDr. Lloyd talks about her new book, "intra-Terrestrials: Discovering the strangest life on Earth."Broadcast 4390: Dr. Saralyn Mark | Tuesday 24 Jun 2025 700PM PTGuests: Dr. Saralyn MarkDr. Mark on advancing human spaceflight and health here on Earth and in space.Broadcast 4391: Hotel Mars with Doug Messier | Wednesday 25 Jun 2025 930AM PTGuests: John Batchelor, Dr. David Livingston, Douglas MessierDoug plans on addressing all things SpaceX, Starship and Elon Musk.Broadcast 4392: BY ZOOM: Dr. Ersilia Vaudo from France | Thursday 26 Jun 2025 930AM PTGuests: Dr. Ersilia VaudoDr. Vaudo will highlight her new book, The Story of Astrophysics in Five Revolutions.Broadcast 4393: Casey Dreier of The Planetary Society | Friday 27 Jun 2025 930AM PTGuests: Casey DreierCasey address the skinny budget for NASA science and space project cutbacksBroadcast 4394: Dr. Young Bay | Sunday 29 Jun 2025 1200PM PTGuests: Dr. Young K. BaeDr. Bay addresses the development of fusion energyLive Streaming is at https://www.thespaceshow.com/content/listen-live with the following live streaming sites:Stream Guys https://player.streamguys.com/thespaceshow/sgplayer3/player.php#FastServ https://ic2646c302.fastserv.com/stream Get full access to The Space Show-One Giant Leap Foundation at doctorspace.substack.com/subscribe

Please note that both the video and the audio of this program are archived on our Substack page, doctorspace.substack.com. I strongly recommend you watch the video version.We introduced Dr. Ersilia Vaudo, an astrophysicist and author from Paris with a 30-year career at ESA, including roles overseeing relations with NASA. He mentions her book and asks about her background in space and her motivation for writing her book, “The Story of Astrophysics in Five Revolutions.” Our guest started us of by sharing her journey into physics and astrophysics, describing how her early interest in science was nurtured by her family and experiences in nature. She explained that her decision to study physics was motivated by a desire to understand the universe and feel empowered by knowledge. Vaudo emphasizes the transformative nature of studying physics, as it challenges one's preconceptions and experiences. When asked if she saw the Moon landings live on TV, she expressed more interest in the scientific aspects of space exploration rather than the adventure itself. Vaudo also discussed her book on astrophysics, which aims to share the wonder of the field with a general audience by connecting historical events and scientific revolutions.Our discussion covered several key developments in cosmology and physics. Vaudo outlines five major revolutions (her book title) in our understanding of the universe: Newton's unification of terrestrial and celestial physics through gravity, Einstein's special and general relativity theories, Hubble's discovery of the expanding universe, and Dirac's contributions to quantum mechanics. I mentioned a recent theory challenge on a current Hotel Mars program to the Big Bang model, suggesting we might be inside a black hole. Vaudo emphasizes the importance of keeping an open mind to new theories while maintaining a focus on experimental evidence.Vaudo discussed the five revolutions covered in his book, ending with the discovery of antimatter. She explained that modern scientific revolutions often involve teams rather than individual scientists, making storytelling today more challenging. John Jossy asked why dark matter and dark energy weren't included as a sixth revolution. Vaudo said that these topics were addressed in the book's final chapter, describing them as mysteries still being explored. She emphasized that dark energy, in particular, remains a fascinating enigma in our understanding of the universe.Vaudo discussed the challenges in science education and research, highlighting the growing impatience for quick answers and the increasing difficulty in generating new ideas. She emphasized the importance of mathematics as a critical thinking tool and suggests starting math education early to reduce anxiety. Vaudo shares his experience with an association that brings hands-on science experiments to disadvantaged areas, noting how this approach sparks curiosity and engagement in children. She also stressed the need for more experiential learning in primary schools to foster interest in science and mathematics.Dr. Vaudo discussed the influence of Galileo on the history of science and astronomy. She highlighted Galileo's contributions, including his use of the telescope, his intuition about the speed of light, and his pioneering work on relativity. Vaudo emphasized Galileo's bravery in challenging consensus and risking resistance to bring new ideas forward. The conversation touched on topics such as inflation theory, dark energy, and the role of funding in scientific exploration. Vaudo mentioned the importance of investing in science, noting that even basic research can lead to significant practical benefits in the future.Special thanks to our sponsors:Northrup Grumman, American Institute of Aeronautics and Astronautics, Helix Space in Luxembourg, Celestis Memorial Spaceflights, Astrox Corporation, Dr. Haym Benaroya of Rutgers University, The Space Settlement Progress Blog by John Jossy, The Atlantis Project, and Artless EntertainmentOur Toll Free Line for Live Broadcasts: 1-866-687-7223For real time program participation, email Dr. Space at: drspace@thespaceshow.comThe Space Show is a non-profit 501C3 through its parent, One Giant Leap Foundation, Inc. To donate via Pay Pal, use:To donate with Zelle, use the email address: david@onegiantleapfoundation.org.If you prefer donating with a check, please make the check payable to One Giant Leap Foundation and mail to:One Giant Leap Foundation, 11035 Lavender Hill Drive Ste. 160-306 Las Vegas, NV 89135Upcoming Programs:Broadcast 4388: Sunday, June 22: 12 PM PDT; Dr. Karen Lloyd re her book “Intra-terrestrials: Discovering the Strangest Life on Earth”Broadcast 4389: Dr. Karen Lloyd | Sunday 22 Jun 2025 1200PM PTGuests: Dr. Karen LloydDr. Lloyd talks about her new book, "intra-Terrestrials: Discovering the strangest life on Earth."Broadcast 4390: Dr. Saralyn Mark | Tuesday 24 Jun 2025 700PM PTGuests: Dr. Saralyn MarkDr. Mark on advancing human spaceflight and health here on Earth and in space.Broadcast 4391: Hotel Mars with Doug Messier | Wednesday 25 Jun 2025 930AM PTGuests: John Batchelor, Dr. David Livingston, Douglas MessierDoug plans on addressing all things SpaceX, Starship and Elon Musk.Broadcast 4392: BY ZOOM: Dr. Ersilia Vaudo from France | Thursday 26 Jun 2025 930AM PTGuests: Dr. Ersilia VaudoDr. Vaudo will highlight her new book, The Story of Astrophysics in Five Revolutions.Broadcast 4393: Casey Dreier of The Planetary Society | Friday 27 Jun 2025 930AM PTGuests: Casey DreierCasey address the skinny budget for NASA science and space project cutbacksBroadcast 4394: Dr. Young Bay | Sunday 29 Jun 2025 1200PM PTGuests: Dr. Young K. BaeDr. Bay addresses the development of fusion energyLive Streaming is at https://www.thespaceshow.com/content/listen-live with the following live streaming sites:Stream Guys https://player.streamguys.com/thespaceshow/sgplayer3/player.php#FastServhttps://ic2646c302.fastserv.com/stream Get full access to The Space Show-One Giant Leap Foundation at doctorspace.substack.com/subscribe

Casey Dreyer, Director of Space Policy at the Planetary Society, joined us in our Space Show Zoom room to discuss the proposed 2026 NASA budget. He criticized the budget as unprecedented, “unstrategic,” and damaging—highlighting a historic 25% cut that could cancel numerous missions and projects. Casey stressed that the budget breaks the Artemis consensus, cuts scientific research, and threatens NASA's workforce. He dismissed the possibility of significant internal savings, arguing that most mission costs are tied to personnel and would require major structural reform. Casey suggested the budget proposal reflected a broader shift in U.S. priorities away from science and questioned the lack of clear space policy leadership from the White House. He attributed the budget's anti-science stance more to Rust Vought of OMB than Elon Musk and noted that NASA was excluded from key budget conversations due to the absence of a confirmed administrator.The group discussed how budget cuts affect commercial space activity and NASA's ability to support it. Casey emphasized the importance of long-term commitments to programs like Artemis to sustain a commercial space economy. While some companies remain successful, many are shifting focus toward defense contracts due to market and funding uncertainties. Zoom participant Phil proposed reframing NASA's mission in terms of national competition with China to align with current political priorities. Casey agreed that emphasizing competition with China might be effective but warned against undermining NASA's nonpartisan image. He noted that while public support exists for NASA's science missions—such as climate observation and planetary defense—human spaceflight to the Moon or Mars is less popular.Casey also addressed potential solutions, including advocating for a supplemental budget or stronger congressional resistance. Zoom listener John H suggested a continuing resolution (CR) may be the most likely outcome, given Senate voting requirements and ongoing reconciliation bill discussions. Casey explained that while a CR might appear manageable, the Office of Management and Budget (OMB) could impose harmful restrictions through aggressive executive interpretation.In discussing congressional prospects, Casey was skeptical about swift action due to a narrow Republican majority and competing legislative priorities. He warned that inaction could have severe consequences and reiterated the importance of public and congressional engagement.The conversation turned to the role of the National Space Council and the implications of JD Vance's leadership. Casey expressed concerns about the lack of strategic guidance and the administration's failure to advocate its own space policy vision. He emphasized the need for policy alternatives to reduce reliance on a single contractor—namely SpaceX—and criticized the current vulnerability of programs like the Space Launch System (SLS).When asked about China's potential to reach the Moon first, Casey speculated that it could lead to a symbolic loss for the U.S., though the political response remains uncertain. He stressed that the administration's lack of public advocacy for NASA's goals is damaging and that human spaceflight's popularity depends heavily on its visibility and perceived success.In closing, Casey described the Planetary Society's advocacy efforts, highlighting their independent and aggressive campaign against the proposed cuts. He reaffirmed the importance of preserving NASA's nonpartisan reputation while pushing for restored funding. He also mentioned an upcoming podcast episode on the NASA budget featuring guests from the Commercial Spaceflight Federation (CSF) and the American Geophysical Union (AGU). The group agreed to remain engaged and offer support to help reverse the budget cuts.Listeners and viewers, much more was discussed during the 1 hour 16 minutes with Casey so be sure to either watch all of the video or listen to all of the audio. We were joined in the Zoom room by Space Show Advisory Board members Bill Gowan, John Jossy, John Hunt, A.J. Kothari, and Dr. Phil Swan. Many more questions were asked of Casey including my end of the program for Casey and/or the Planetary Society to create an alternate budget to use in working to move away from the proposed skinny budget. Such an alternate budget by those who know and are familiar with space, science and NASA would also be a terrific and relevant handout to members of congress, staffers and even the president and his office. I hope Casey and his associates follow through on this suggestion. Please post your comments on either TSS blog for this program or our Substack page, doctorspace.substack.com.Special thanks to our sponsors:Northrup Grumman, American Institute of Aeronautics and Astronautics, Helix Space in Luxembourg, Celestis Memorial Spaceflights, Astrox Corporation, Dr. Haym Benaroya of Rutgers University, The Space Settlement Progress Blog by John Jossy, The Atlantis Project, and Artless EntertainmentOur Toll Free Line for Live Broadcasts: 1-866-687-7223For real time program participation, email Dr. Space at: drspace@thespaceshow.comThe Space Show is a non-profit 501C3 through its parent, One Giant Leap Foundation, Inc. To donate via Pay Pal, use:To donate with Zelle, use the email address: david@onegiantleapfoundation.org.If you prefer donating with a check, please make the check payable to One Giant Leap Foundation and mail to:One Giant Leap Foundation, 11035 Lavender Hill Drive Ste. 160-306 Las Vegas, NV 89135Upcoming Programs:Broadcast 4388: Sunday, June 22: 12 PM PDT; Dr. Karen Lloyd re her book “Intra-terrestrials: Discovering the Strangest Life on Earth”Broadcast 4389: Dr. Karen Lloyd | Sunday 22 Jun 2025 1200PM PTGuests: Dr. Karen LloydDr. Lloyd talks about her new book, "intra-Terrestrials: Discovering the strangest life on Earth."Broadcast 4390: Dr. Saralyn Mark | Tuesday 24 Jun 2025 700PM PTGuests: Dr. Saralyn MarkDr. Mark on advancing human spaceflight and health here on Earth and in space.Broadcast 4391: Hotel Mars with Doug Messier | Wednesday 25 Jun 2025 930AM PTGuests: John Batchelor, Dr. David Livingston, Douglas MessierDoug plans on addressing all things SpaceX, Starship and Elon Musk.Broadcast 4392: BY ZOOM: Dr. Ersilia Vaudo from France | Thursday 26 Jun 2025 930AM PTGuests: Dr. Ersilia VaudoDr. Vaudo will highlight her new book, The Story of Astrophysics in Five Revolutions.Broadcast 4393: Casey Dreier of The Planetary Society | Friday 27 Jun 2025 930AM PTGuests: Casey DreierCasey address the skinny budget for NASA science and space project cutbacksBroadcast 4394: Dr. Young Bay | Sunday 29 Jun 2025 1200PM PTGuests: Dr. Young K. BaeDr. Bay addresses the development of fusion energyLive Streaming is at https://www.thespaceshow.com/content/listen-live with the following live streaming sites:Stream Guys https://player.streamguys.com/thespaceshow/sgplayer3/player.php#FastServ https://ic2646c302.fastserv.com/stream Get full access to The Space Show-One Giant Leap Foundation at doctorspace.substack.com/subscribe

Please note that there were audio and technical difficulties with this program My apologies.Dr. Karen Lloyd, author of INTRATERRESTRIALS: Discovering The Strangest Life On Earth, was our guest for this 63-minute program. We explored a variety of strange life forms that she has studied using deep-sea submersibles such as ALVIN. Although we did touch on some land-based life later in the program, most of our discussion focused on organisms found several hundred to several thousand feet below the ocean surface.Early in the conversation, I asked Karen about DNA differences between these deep-sea organisms and surface creatures. She reminded us that her research primarily involves single-celled microbial life, but noted that their DNA is not drastically different from that of more familiar organisms.As a former scuba diver in my younger years, I asked several questions about the experience of deep-sea diving in mini-subs: the technology involved, the comfort level (or lack thereof), visibility, and the challenges of discovering and retrieving samples for study. Karen also shared insights about the crew—typically just three people per dive in ALVIN—the duration of these dives, and the training required to participate. One key takeaway was that many samples are collected from seafloor mud, as the life forms are too small to be seen with the naked eye.Despite ongoing audio issues during the broadcast, we received several excellent listener questions. One listener asked whether the organisms Karen studies are considered extremophiles—a topic we've discussed before on TSS. Don't miss her answer—it may surprise you. Another caller inquired about any commercial applications for her research or for the microbial life itself. Karen took time to name some of the organisms currently being studied, so listen closely for those details.A listener also raised concerns about ocean pollution and its impact on these life forms. While most of the organisms live too deep to be directly affected, Karen did discuss the broader dangers of plastic and other pollution, stressing that we should take these issues more seriously.Later in the program, we tackled a complex question about whether climate change is affecting these deep-sea environments. Karen gave a detailed response that's worth hearing in full. I also asked if microbial life differs across the world's oceans. While there is some diversity, she explained that the microbes are generally quite similar across different marine environments. She was also asked about microbial life in freshwater lakes, but noted that this is not a primary focus of her research.As the discussion continued, I asked Karen about the potential benefits to humans from studying these life forms. Her response was thoughtful and informative—another part of the program you won't want to miss. Before wrapping up, we discussed how these microorganisms contribute to oxygen production. I mentioned that I thought trees were responsible for that, and Karen explained the significant differences. She emphasized how essential deep-ocean microbial life is to sustaining human life with some good examples.Karen dives into all of this and much more in her book, which is an excellent and engaging read. She shares vivid stories that help readers appreciate the science and the importance of this research. While we did experience some audio issues during the show, I encourage you to listen to the entire interview and consider reading her book. This is a truly important subject that deserves our attention.Special thanks to our sponsors:Northrup Grumman, American Institute of Aeronautics and Astronautics, Helix Space in Luxembourg, Celestis Memorial Spaceflights, Astrox Corporation, Dr. Haym Benaroya of Rutgers University, The Space Settlement Progress Blog by John Jossy, The Atlantis Project, and Artless EntertainmentOur Toll Free Line for Live Broadcasts: 1-866-687-7223For real time program participation, email Dr. Space at: drspace@thespaceshow.comThe Space Show is a non-profit 501C3 through its parent, One Giant Leap Foundation, Inc. To donate via Pay Pal, use:To donate with Zelle, use the email address: david@onegiantleapfoundation.org.If you prefer donating with a check, please make the check payable to One Giant Leap Foundation and mail to:One Giant Leap Foundation, 11035 Lavender Hill Drive Ste. 160-306 Las Vegas, NV 89135Upcoming Programs:Broadcast 4388: Sunday, June 22: 12 PM PDT; Dr. Karen Lloyd re her book “Intra-terrestrials: Discovering the Strangest Life on Earth”Broadcast 4389: Dr. Karen Lloyd | Sunday 22 Jun 2025 1200PM PTGuests: Dr. Karen LloydDr. Lloyd talks about her new book, "intra-Terrestrials: Discovering the strangest life on Earth."Broadcast 4390: Dr. Saralyn Mark | Tuesday 24 Jun 2025 700PM PTGuests: Dr. Saralyn MarkDr. Mark on advancing human spaceflight and health here on Earth and in space.Broadcast 4391: Hotel Mars with Doug Messier | Wednesday 25 Jun 2025 930AM PTGuests: John Batchelor, Dr. David Livingston, Douglas MessierDoug plans on addressing all things SpaceX, Starship and Elon Musk.Broadcast 4392: BY ZOOM: Dr. Ersilia Vaudo from France | Thursday 26 Jun 2025 930AM PTGuests: Dr. Ersilia VaudoDr. Vaudo will highlight her new book, The Story of Astrophysics in Five Revolutions.Broadcast 4393: Casey Dreier of The Planetary Society | Friday 27 Jun 2025 930AM PTGuests: Casey DreierCasey address the skinny budget for NASA science and space project cutbacksBroadcast 4394: Dr. Young Bay | Sunday 29 Jun 2025 1200PM PTGuests: Dr. Young K. BaeDr. Bay addresses the development of fusion energyLive Streaming is at https://www.thespaceshow.com/content/listen-live with the following live streaming sites:Stream Guys https://player.streamguys.com/thespaceshow/sgplayer3/player.php#FastServhttps://ic2646c302.fastserv.com/stream Get full access to The Space Show-One Giant Leap Foundation at doctorspace.substack.com/subscribe

We welcomed Dr. Robert Bishop of Texas A&M University to The Space Show for a wide-ranging discussion on space exploration, technology, and education—highlighting Texas A&M's expanding leadership in space science, engineering, and research.After introducing the program and reminding listeners that The Space Show is a nonprofit, listener-supported initiative, I welcomed our guest, Dr. Robert Bishop, Vice Chancellor and Dean of Engineering at Texas A&M. Dr. Bishop began by outlining the university's major space and science research initiatives. While state-supported, he explained, much of the research is funded through contracts and grants from NASA, the National Science Foundation (NSF), and other agencies. A key development is a new 400,000-square-foot research facility under construction near NASA's Johnson Space Center, featuring simulated lunar and Martian environments for both academic and industry use.Dr. Bishop addressed concerns about potential federal science funding cuts. He expressed confidence in adapting through more efficient funding models, such as forming a 501(c)(3) and expanding contract-based research. He emphasized that contracts should supplement—not replace—traditional grant funding, especially for open-ended basic research. He also called for a reevaluation of indirect cost structures to better sustain future research.We explored Texas A&M's national security-related research, including work in cybersecurity, hypersonics, and space defense. Dr. Bishop underscored the university's partnerships with federal and military organizations and emphasized the need to safeguard critical infrastructure amid rising global competition in space. He expressed concern about the uncertain future of U.S. space dominance.Dr. Bishop also introduced the TAMU Spirit platform, developed by Aegis Aerospace, which will host up to 12 experiments every six months aboard the International Space Station (ISS). While acknowledging the ISS's limited remaining operational timeline, he confirmed that contingency planning is underway for future commercial platforms.On space launch, I raised concerns about reliance on SpaceX and recent Starship test failures. Dr. Bishop noted that launch systems fall outside his expertise but acknowledged the importance of diversified infrastructure.We discussed Texas A&M's new space engineering program, which began as a master's degree in Fall 2023 and will expand to a bachelor's program in Fall 2024. The program integrates disciplines such as agriculture, architecture, and public policy, with a focus on sustaining human life on the Moon and Mars. While the university is not involved in space medicine or weapons research, it conducts foundational research in hypersonics and maintains active collaborations with astronauts and researchers at JSC.Our conversation also touched on the broader Texas space ecosystem, with contributions from UT Austin, Rice, and Baylor. Dr. Bishop emphasized the importance of interdisciplinary research—including studies on the environmental impact of space exploration and the use of small modular nuclear reactors for lunar power. In response to a listener question, he noted that while A&M is not currently working on space-based solar power, they are actively researching nuclear technologies for both Earth and space applications.Dr. Bishop spoke to the surging demand for engineering education at Texas A&M, which enrolls over 25,000 engineering students but still cannot meet national workforce needs. On the topic of AI, he described early efforts to create a comparative framework across disciplines, with ethical considerations woven throughout the curriculum—not as standalone courses, but through an integrated, vertical approach. He stressed academia's responsibility in helping industry navigate the ethical challenges of space exploration.In response to one of the many listener questions for this program, we discussed commercial opportunities in cislunar space, including communication, landing, and timing infrastructure. Dr. Bishop described cislunar space as a testbed for Earth-beneficial technologies like space medicine and advanced systems. We also explored concepts such as cycling trajectories between Earth and the Moon, space tourism, and large-scale orbital construction. While he believes current engineering capabilities can support such ambitions, he pointed to the need for more robust launch infrastructure Dr. Bishop highlighted Texas A&M's contributions to food production research aboard the ISS and noted the ongoing challenges of limited resources and talent shortages. He spoke positively about the university's close ties with government stakeholders and voiced support for bold space development goals. Before concluding, we briefly touched on student enthusiasm, space settlement, O'Neilian colonies, superstructures, and the emerging potential of space medicine.We invite you to share your thoughts and questions for Dr. Bishop on our Space Show blog or Substack page: doctorspace.substack.com.Special thanks to our sponsors:Northrup Grumman, American Institute of Aeronautics and Astronautics, Helix Space in Luxembourg, Celestis Memorial Spaceflights, Astrox Corporation, Dr. Haym Benaroya of Rutgers University, The Space Settlement Progress Blog by John Jossy, The Atlantis Project, and Artless EntertainmentOur Toll Free Line for Live Broadcasts: 1-866-687-7223For real time program participation, email Dr. Space at: drspace@thespaceshow.comThe Space Show is a non-profit 501C3 through its parent, One Giant Leap Foundation, Inc. To donate via Pay Pal, use:To donate with Zelle, use the email address: david@onegiantleapfoundation.org.If you prefer donating with a check, please make the check payable to One Giant Leap Foundation and mail to:One Giant Leap Foundation, 11035 Lavender Hill Drive Ste. 160-306 Las Vegas, NV 89135Upcoming Programs:Broadcast 4388: Sunday, June 22: 12 PM PDT; Dr. Karen Lloyd re her book “Intra-terrestrials: Discovering the Strangest Life on Earth”Broadcast 4389: Dr. Karen Lloyd | Sunday 22 Jun 2025 1200PM PTGuests: Dr. Karen LloydDr. Lloyd talks about her new book, "intra-Terrestrials: Discovering the strangest life on Earth."Broadcast 4390: Dr. Saralyn Mark | Tuesday 24 Jun 2025 700PM PTGuests: Dr. Saralyn MarkDr. Mark on advancing human spaceflight and health here on Earth and in space.Broadcast 4391: Hotel Mars with Doug Messier | Wednesday 25 Jun 2025 930AM PTGuests: John Batchelor, Dr. David Livingston, Douglas MessierDoug plans on addressing all things SpaceX, Starship and Elon Musk.Broadcast 4392: BY ZOOM: Dr. Ersilia Vaudo from France | Thursday 26 Jun 2025 930AM PTGuests: Dr. Ersilia VaudoDr. Vaudo will highlight her new book, The Story of Astrophysics in Five Revolutions.Broadcast 4393: Casey Dreier of The Planetary Society | Friday 27 Jun 2025 930AM PTGuests: Casey DreierCasey address the skinny budget for NASA science and space project cutbacksBroadcast 4394: Dr. Young Bay | Sunday 29 Jun 2025 1200PM PTGuests: Dr. Young K. BaeDr. Bay addresses the development of fusion energyLive Streaming is at https://www.thespaceshow.com/content/listen-live with the following live streaming sites:Stream Guys https://player.streamguys.com/thespaceshow/sgplayer3/player.php#FastServhttps://ic2646c302.fastserv.com/stream Get full access to The Space Show-One Giant Leap Foundation at doctorspace.substack.com/subscribe

John and I welcomed Dr. Enrique Gaztañaga from the University of Portsmouth in the UK. Dr. Gaztañaga presented an alternative theory of the universe that challenges the established Big Bang model. Since the James Webb Space Telescope (JWST) came online, observations have raised questions about the standard Big Bang theory—questions that Dr. Gaztañaga has been at the forefront of addressing through his new theoretical framework, which is still under active investigation and referred to as the Black Hole Universe Theory.As you listen to this two-part program, we encourage you to visit Dr. Gaztañaga's excellent website at https://darkcosmos.com for more details and a comprehensive list of his published articles. You can also read his latest peer-reviewed work in Physical Review D.To briefly summarize from his website: “The Big Bang was not the start of everything, but rather the outcome of a gravitational collapse that formed a very massive black hole — followed by a bounce inside. This idea — which we call the Black Hole Universe — offers a radically different view of cosmic origins, yet it is grounded entirely in known physics and observations.”Be sure to check out his papers and learn more about this bold and intriguing theory. We're certain Dr. Gaztañaga will be a returning guest on Hotel Mars and The Space Show in the future.Special thanks to our sponsors:Northrup Grumman, American Institute of Aeronautics and Astronautics, Helix Space in Luxembourg, Celestis Memorial Spaceflights, Astrox Corporation, Dr. Haym Benaroya of Rutgers University, The Space Settlement Progress Blog by John Jossy, The Atlantis Project, and Artless EntertainmentOur Toll Free Line for Live Broadcasts: 1-866-687-7223For real time program participation, email Dr. Space at: drspace@thespaceshow.comThe Space Show is a non-profit 501C3 through its parent, One Giant Leap Foundation, Inc. To donate via Pay Pal, use:To donate with Zelle, use the email address: david@onegiantleapfoundation.org.If you prefer donating with a check, please make the check payable to One Giant Leap Foundation and mail to:One Giant Leap Foundation, 11035 Lavender Hill Drive Ste. 160-306 Las Vegas, NV 89135Upcoming Programs:Broadcast 4389: Sunday, June 22: 12 PM PDT; Dr. Karen Lloyd re her book “Intra-terrestrials: Discovering the Strangest Life on Earth”Live Streaming is at https://www.thespaceshow.com/content/listen-live with the following live streaming sites:Stream Guys https://player.streamguys.com/thespaceshow/sgplayer3/player.php#FastServ https://ic2646c302.fastserv.com/stream Get full access to The Space Show-One Giant Leap Foundation at doctorspace.substack.com/subscribe

John and I welcomed back Eric Berger of Ars Technica to Hotel Mars for a one-segment update and discussion on SpaceX, Elon Musk, and Starship. We began by asking Eric what successful Starship testing would look like for SpaceX. He acknowledged that it's difficult to define clear success metrics at this stage.We then discussed the upcoming Demo Test #10, potential hardware and assembly issues, plus Eric elaborated on some of the challenges SpaceX might face. The conversation touched on Starship's role in NASA's planned Moon missions, the importance of testing in low Earth orbit (LEO), and the need to develop and demonstrate in-orbit refueling capabilities. Eric spoke about the types of fuel Starship uses and highlighted the need to address issues like boil-off during storage in space.Before concluding, we asked Eric about the ongoing feud between Elon Musk and President Trump. Eric said it was hard to predict how things would unfold but thought Musk might walk back some of his comments. He emphasized the strategic importance of SpaceX to the U.S. government in both civil space and national security domains. While the FAA could theoretically delay permits in response to Musk's remarks, Eric didn't think that was likely at this time.Special thanks to our sponsors:Northrup Grumman, American Institute of Aeronautics and Astronautics, Helix Space in Luxembourg, Celestis Memorial Spaceflights, Astrox Corporation, Dr. Haym Benaroya of Rutgers University, The Space Settlement Progress Blog by John Jossy, The Atlantis Project, and Artless EntertainmentOur Toll Free Line for Live Broadcasts: 1-866-687-7223For real time program participation, email Dr. Space at: drspace@thespaceshow.comThe Space Show is a non-profit 501C3 through its parent, One Giant Leap Foundation, Inc. To donate via Pay Pal, use:To donate with Zelle, use the email address: david@onegiantleapfoundation.org.If you prefer donating with a check, please make the check payable to One Giant Leap Foundation and mail to:One Giant Leap Foundation, 11035 Lavender Hill Drive Ste. 160-306 Las Vegas, NV 89135Upcoming Programs:Broadcast 4387: By Zoom: Friday, 6-20 @!09:30 AM PDDTDr. Robert Bishop, Texas A&M Dean on AI, Cyber, Defense Tech & SpaceBroadcast 4388: Sunday, June 22: 12 PM PDT; Dr. Karen Lloyd re her book “Intra-terrestrials: Discovering the Strangest Life on Earth”Live Streaming is at https://www.thespaceshow.com/content/listen-live with the following live streaming sites:Stream Guys https://player.streamguys.com/thespaceshow/sgplayer3/player.php#FastServ https://ic2646c302.fastserv.com/stream Get full access to The Space Show-One Giant Leap Foundation at doctorspace.substack.com/subscribe

Lisa Carlin, Sandra Herrera, and Aaron West recap TST as two members of Attacking Third faced off in the final. Then, the group explain both Intra-League Loans in the NWSL and the Building Assets that expansion sides Boston and Denver will receive for their inaugural season in 2026. And finally, the A3 Mailbag is opened once again to answer your questions. Watch USWNT and NWSL games on P+" with a link to ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.paramountplus.com/home/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ Attacking Third is available for free on the Audacy app as well as Apple Podcasts, Spotify, Google Podcasts, Stitcher and wherever else you listen to podcasts.  Follow the Attacking Third team on Twitter: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@AttackingThird⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@LisaCarlin32⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@SandHerrera_⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@Darian_Jenks⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠, and ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠@CCupo⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Visit the Attacking Third YouTube channel: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.youtube.com/attackingthird⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ You can listen to Attacking Third on your smart speakers! Simply say "Alexa, play the latest episode of the Attacking Third podcast" or "Hey Google, play the latest episode of the Attacking Third podcast." To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Welcome to Season 2 of the Orthobullets Podcast. Today's show is Coinflips, where expert speakers discuss grey zone decisions in orthopedic surgery. This episode will feature doctors Damayea Hargett, Emily Benson, John Scolaro, & Charles Moon. They will discuss the case titled "⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Open Segmental Femur Fx with Distal Intra-articular Extension in 25M⁠⁠⁠.⁠⁠⁠⁠⁠⁠" Follow ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Orthobullets⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ on Social Media:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Twitter⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Linkedln⁠

In this episode Derek Champagne talks with Shark Tank veteran Yannis Moati. Yannis is the Founder & CEO of Hotels by Day, which seamlessly unlocks latent intra-day room inventory, bringing guests the flexibility of short stays. Intra-day rooms being the inventory of unsold rooms from the night before pooled with early checkouts.Yannis shares his experiences launching his new business and growing his national brand.Learn more at www.hotelsbyday.com

Drs. Amy Crockett (@amyhcrockett), Ben Ereshefsky (@brainofbpharm), and Pamela Bailey (@pamipenem) join Dr. Julie Ann Justo (@julie_justo) to discuss new treatment strategies for management of intraamniotic infections, also known as chorioamnionitis. They discuss whether it is time to move away from the combination of ampicillin, gentamicin, and/or clindamycin, alternative antibiotic regimens to consider, and stewardship strategies to approach this practice change at a local level. References: Basic stats/epi on chorioamnionitis: Romero R, et al. Clinical chorioamnionitis at term I: microbiology of the amniotic cavity using cultivation and molecular techniques. J Perinat Med. 2015 Jan;43(1):19-36. doi: 10.1515/jpm-2014-0249. PMID: 25720095. ACOG 2017 Guideline for IAI: Committee Opinion No. 712: Intrapartum Management of Intraamniotic Infection. Obstet Gynecol. 2017 Aug;130(2):e95-e101. doi: 10.1097/AOG.0000000000002236. PMID: 28742677. ACOG 2024 Update on clinical criteria for IAI: ACOG Clinical Practice Update: Update on Criteria for Suspected Diagnosis of Intraamniotic Infection. Obstetrics & Gynecology 144(1):p e17-e19, July 2024. doi: 10.1097/AOG.0000000000005593 Helpful review with more recent microorganisms : Jung E, et al. Clinical chorioamnionitis at term: definition, pathogenesis, microbiology, diagnosis, and treatment. Am J Obstet Gynecol. 2024 Mar;230(3S):S807-S840. doi: 10.1016/j.ajog.2023.02.002. PMID: 38233317. Cochrane Review: Chapman E, et al. Antibiotic regimens for management of intra-amniotic infection. Cochrane Database Syst Rev. 2014 Dec 19;2014(12):CD010976. doi: 10.1002/14651858.CD010976.pub2. PMID: 25526426. Helpful recent review on intrapartum infections: Bailey, P, et al_._ Out with the Old, In with the New: A Review of the Treatment of Intrapartum Infections. Curr Infect Dis Rep. 2024;26:107–113 doi: 10.1007/s11908-024-00838-8. Role of genital mycoplasmas in IAI: Romero R, et al. Evidence that intra-amniotic infections are often the result of an ascending invasion - a molecular microbiological study. J Perinat Med. 2019 Nov 26;47(9):915-931. doi: 10.1515/jpm-2019-0297. PMID: 31693497. Regimens without enterococcal coverage with similar clinical outcomes: Blanco JD, et al. Randomized comparison of ceftazidime versus clindamycin-tobramycin in the treatment of obstetrical and gynecological infections. Antimicrob Agents Chemother. 1983 Oct;24(4):500-4. doi: 10.1128/AAC.24.4.500. PMID: 6360038. Bookstaver PB, et al. A review of antibiotic use in pregnancy. Pharmacotherapy. 2015 Nov;35(11):1052-62. doi: 10.1002/phar.1649. PMID: 26598097. Updated review in pregnancy, includes data on frequency of antibiotic use in pregnancy: Nguyen J, et al. A review of antibiotic safety in pregnancy-2025 update. Pharmacotherapy. 2025 Apr;45(4):227-237. doi: 10.1002/phar.70010. Epub 2025 Mar 19. PMID: 40105039. Locksmith GJ, et al. High compared with standard gentamicin dosing for chorioamnionitis: a comparison of maternal and fetal serum drug levels. Obstet Gynecol. 2005 Mar;105(3):473-9. doi: 10.1097/01.AOG.0000151106.87930.1a. PMID: 15738010. Clindamycin CDI Risk: Miller AC, et al. Comparison of Different Antibiotics and the Risk for Community-Associated Clostridioides difficile Infection: A Case-Control Study. Open Forum Infect Dis. 2023 Aug 5;10(8):ofad413. doi: 10.1093/ofid/ofad413. PMID: 37622034. Impact of penicillin allergy on clindamycin use & cites 47% clindamycin resistance per CDC among GBS: Snider JB, et al. Antibiotic choice for Group B Streptococcus prophylaxis in mothers with reported penicillin allergy and associated newborn outcomes. BMC Pregnancy Childbirth. 2023 May 30;23(1):400. doi: 10.1186/s12884-023-05697-0. PMID: 37254067. Clindamycin anaerobic coverage data: Hastey CJ, et al. Changes in the antibiotic susceptibility of anaerobic bacteria from 2007-2009 to 2010-2012 based on the CLSI methodology. Anaerobe. 2016 Dec;42:27-30. doi: 10.1016/j.anaerobe.2016.07.003. PMID: 27427465. Older PK study of ampicillin & gentamicin for chorioamnionitis: Gilstrap LC 3rd, Bawdon RE, Burris J. Antibiotic concentration in maternal blood, cord blood, and placental membranes in chorioamnionitis. Obstet Gynecol. 1988 Jul;72(1):124-5. PMID: 3380500. Paper putting out the call for modernization of OB/Gyn antibiotic regimens: Pek Z, Heil E, Wilson E. Getting With the Times: A Review of Peripartum Infections and Proposed Modernized Treatment Regimens. Open Forum Infect Dis. 2022 Sep 5;9(9):ofac460. doi: 10.1093/ofid/ofac460. PMID: 36168554. Vanderbilt University Medical Center experience with modernizing OB/Gyn infection regimens: Smiley C, et al. Implementing Updated Intraamniotic Infection Guidelines at a Large Academic Medical Center. Open Forum Infect Dis. 2024 Sep 5;11(9):ofae475. doi: 10.1093/ofid/ofae475. PMID: 39252868. Prisma Health/University of South Carolina experience with modernizing OB/Gyn infection regimens: Bailey P, et al. Cefoxitin for Intra-amniotic Infections and Endometritis: A Retrospective Comparison to Traditional Antimicrobial Therapy Regimens Within a Healthcare System. Clin Infect Dis. 2024 Jul 19;79(1):247-254. doi: 10.1093/cid/ciae042. PMID: 38297884.

Two governors walk into the Reagan Library and find common ground. Steve Hayes is joined by Utah Governor Spencer Cox (R) and New Mexico Governor Michelle Lujan Grisham (D), to discuss bipartisanship, mutual respect, and the value of healthy conflict. The Agenda:—Defining tribes—Media outrage and news cycles—We should all join bowling teams—We can't explain policy in 280 characters—Intra-party tensions Learn more about your ad choices. Visit megaphone.fm/adchoices