Podcast appearances and mentions of Eric Betzig

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3504: Cal Newport highlights Eric Betzig's unconventional path to a Nobel Prize to reveal a key insight, real success comes from doing what it takes, not just refining what we already know. He challenges us to stop making safe tweaks and start taking bold steps toward true breakthroughs. Read along with the original article(s) here: https://calnewport.com/doing-what-it-takes-versus-taking-what-you-already-know-how-to-do/ Quotes to ponder: "When Eric Betzig wanted to return to academia, he asked, 'what would this take?' The answer was daunting, a breakthrough too good to be ignored, but nonetheless he hustled to make it happen." "We take what we can do, in other words, instead of facing the reality of what it would take to get where we want to go." "I also suspect that one of the main filters between those who end up changing the world and those who don't is how they answer this unavoidable prompt." Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3504: Cal Newport highlights Eric Betzig's unconventional path to a Nobel Prize to reveal a key insight, real success comes from doing what it takes, not just refining what we already know. He challenges us to stop making safe tweaks and start taking bold steps toward true breakthroughs. Read along with the original article(s) here: https://calnewport.com/doing-what-it-takes-versus-taking-what-you-already-know-how-to-do/ Quotes to ponder: "When Eric Betzig wanted to return to academia, he asked, 'what would this take?' The answer was daunting, a breakthrough too good to be ignored, but nonetheless he hustled to make it happen." "We take what we can do, in other words, instead of facing the reality of what it would take to get where we want to go." "I also suspect that one of the main filters between those who end up changing the world and those who don't is how they answer this unavoidable prompt." Learn more about your ad choices. Visit megaphone.fm/adchoices

Discover all of the podcasts in our network, search for specific episodes, get the Optimal Living Daily workbook, and learn more at: OLDPodcast.com. Episode 3504: Cal Newport highlights Eric Betzig's unconventional path to a Nobel Prize to reveal a key insight, real success comes from doing what it takes, not just refining what we already know. He challenges us to stop making safe tweaks and start taking bold steps toward true breakthroughs. Read along with the original article(s) here: https://calnewport.com/doing-what-it-takes-versus-taking-what-you-already-know-how-to-do/ Quotes to ponder: "When Eric Betzig wanted to return to academia, he asked, 'what would this take?' The answer was daunting, a breakthrough too good to be ignored, but nonetheless he hustled to make it happen." "We take what we can do, in other words, instead of facing the reality of what it would take to get where we want to go." "I also suspect that one of the main filters between those who end up changing the world and those who don't is how they answer this unavoidable prompt." Learn more about your ad choices. Visit megaphone.fm/adchoices

Luke Lavis is a senior group leader and head of molecular tools and imaging at HHMI's Janelia Research Campus. Luke Lavis works at the interface of chemistry and biology, developing small-molecule fluorescent dyes to illuminate biological samples. Lavis and his team use modern organic chemistry to design and synthesize bright fluorescent labels for imaging structures inside living cells. By combining these novel compounds with advances in instrumentation, protein engineering, and genetic manipulation, the Lavis Lab and their collaborators devise sophisticated bioimaging experiments at different scales ranging from tracking single molecules to measuring neural activity in cells and animals. “I sometimes call Luke our secret weapon here. Every advance I've made in my career has been due to fluorescent probes.” - Eric Betzig, Nobel Prize Laureate in Chemistry for 2014

#23 — Creativity in Science: How a Good Imagination Can Help Your Research If you're stuck in a research rut in the lab, developing your creativity can help you find new solutions to current problems that may be impeding your scientific progress. In this episode, we explore 3 important questions you should consider to help spark your creativity in the lab and provide 8 simple tips to help achieve this. Read the full article on boosting your creativity in science. [1] If you are looking for further advice, make sure you listen to our Happy Scientist Podcast episode on Imagination, which covers even more ways to boost your imagination and creativity. [2] Consider the importance of allowing yourself time to think and reflect. [3] Finally, listen to this episode of the Microscopists featuring Eric Betzig, where the Nobel Laureate reveals how his biggest ideas came during his two periods of unemployment. [3] Resources: 1. Creativity in Science: How a Good Imagination Can Help Your Research. Available at: https://bitesizebio.com/63742/creativity-in-science/ 2. Episode 33 — How to Foster Imagination. Available at : https://bitesizebio.com/podcast/episode-33-how-to-foster-imagination/ 3. Time to Think. Available at: https://bitesizebio.com/146/time-to-think/ 4. Eric Betzig (University of California). Available at: https://bitesizebio.com/podcast/eric-betzig/

In der zweiten Folge der Reihe UnderDocs x Leopoldina spricht Ronja mit Prof. Dr. Stefan Hell. Er ist Direktor der Max-Planck-Institute für multidisziplinäre Naturwisssenschaften und medizinische Forschung und erhielt zusammen mit Eric Betzig und William E. Moerner für die Entwicklung hochauflösender Fluoreszenzmikroskopie den Nobelpreis für Chemie 2014. Er spricht über die Notwendigkeit eingefahrene Denkmuster zu hinterfragen sowie das Überschreiten vermeintlicher Grenzen des Möglichen und seine Hoffnung auf weitere Durchbrüche bei der Behandlung von Krankheiten.

#25 — Harald Hess is a pioneer in the fields of high-throughput electron microscopy and super-resolution 3D microscopy, and today we'll discover more about what inspired him, his move from academia to industry and back again, and who comes off best in his tennis matches with Eric Betzig.We'll hear how Harald and Eric built the first super-resolution microscope for PALM microscopy in Harald's front room, what his mother thought of the first PALM images, and why science needs different approaches to progress.Watch or Listen to all episodes of The Microscopists here: https://themicroscopists.bitesizebio.com/

#25 – Harald Hess is a pioneer in the fields of high-throughput electron microscopy and super-resolution 3D microscopy, and today we'll discover more about what inspired him, his move from academia to industry and back again, and who comes off best in his tennis matches with Eric Betzig. We'll hear how Harald and Eric built the first super-resolution microscope for PALM microscopy in Harald's front room, what his mother thought of the first PALM images, and why science needs different approaches to progress.

#12 — This episode of The Microscopists was recorded LIVE with a very special guest - Eric Betzig!We already know so much about Eric, but I hope that our chat will reveal more about the man behind the many ingenious contributions to the world of microscopy, life sciences, and science in general.While Eric is well known for receiving the 2014 Nobel Prize for Chemistry along with Stefan Hell and William Moerner for developing super-resolution fluorescence microscopy, you might be surprised to hear that he doesn't consider himself a chemist at all.Join us as we talk about the challenges and excitement of building a living room microscope, moving from academia to industry and back again, and how being a house husband led to a scientific breakthrough.As this was recorded as a live event, the audience had the opportunity to put their own questions to Eric. Coffee or tea? Omnivore or Vegan? Ultrastructure or cellular dynamics?While we don't quite get the answer to the meaning of life, the universe, and everything, we do get to know Eric Betzig on a personal level.Watch or Listen to all episodes of The Microscopists here: https://themicroscopists.bitesizebio.com/

#12 This episode of The Microscopists was recorded LIVE with a very special guest - Eric Betzig! We already know so much about Eric, but I hope that our chat will reveal more about the man behind the many ingenious contributions to the world of microscopy, life sciences, and science in general. While Eric is well known for receiving the 2014 Nobel Prize for Chemistry along with Stefan Hell and William Moerner for developing super-resolution fluorescence microscopy, you might be surprised to hear that he doesn’t consider himself a chemist at all. Join us as we talk about the challenges and excitement of building a living room microscope, moving from academia to industry and back again, and how being a house husband led to a scientific breakthrough. As this was recorded as a live event, the audience had the opportunity to put their own questions to Eric. Coffee or tea? Omnivore or Vegan? Ultrastructure or cellular dynamics? While we don’t quite get the answer to the meaning of life, the universe, and everything, we do get to know Eric Betzig on a personal level. Browse all The Microscopists episodes here: http://bit.ly/the-microscopists-pds

Welcome to the latest episode from the Nerds. We have been lucky to have some glorious rain this week and have enjoyed it. Now for those who want to get healthy without the exercise we have news that will make you happy. There is research into a new protein that has delivered very interesting results so far. It is still a long way from human trials but so far it is looking promising. If it works it will help boost the health of people everywhere. Now, you are keen to know what this break-through is now aren’t you, well, you know what to do. That’s right folks, listen in and hear all about it.Next up we have news about a Violet Evergarden movie that is looking awesome. We know that you will enjoy this fine offering from Kyoto Studios. The movie involves Violet helping someone feeling trapped and missing someone they care about. We haven’t seen it yet so we can’t give you any spoilers, but with what we have managed to get hold of it is looking awesome. We invite you to listen in to learn more about it and hear what the Nerds think.Now last up we have Professor, who had trouble with water in his internet. This week he brings us news about Star Citizen, and it is looking interesting. We have the latest news about the law suit that was looming over the engine being used. We have news about a number of things surrounding this game. Which folks; is apparently now available for purchase at the low price of$40, or if you want to own your very own instant fleet that is an option. Yes Buck does his usual rant about the game and is a complete Boomer about it.As usual we have the game reviews, shout outs, remembrances, birthdays, and special events of interest. We hope you enjoy this episode and as always remember to stay safe, look out for each other and stay hydrated.A protein called Sestrin - https://phys.org/news/2020-01-protein-sestrin-responsible-benefits-good.htmlViolet Evergarden spin off movie - https://www.animenewsnetwork.com/news/2020-01-12/funimation-to-screen-violet-evergarden-i-eternity-and-the-auto-memory-doll-anime-in-u.s-theaters/.155272Unexpected Star Citizen news- https://www.reddit.com/r/Games/comments/ejedi8/star_citizen_lawsuit_takes_an_unexpected_turn_and/- https://cloudimperiumgames.com/blog/corporate/cloud-imperium-financials-for-2018- https://www.youtube.com/watch?v=9smKcy26Z5s&feature=youtu.be- https://robertsspaceindustries.com/spectrum/community/SC/forum/3/thread/staggered-development-faq-1Games currently playingBuck– Dragon Awaken - https://store.steampowered.com/app/824300/Dragon_Awaken/Rating – 3/5DJ– Project Darwin - https://store.steampowered.com/app/544920/Darwin_Project/Rating – 4/5Professor– Heat Signature - https://store.steampowered.com/app/268130/Heat_Signature/Rating – 4.8/5Other topics discussedDrosophila (a genus of flies, belonging to the family Drosophilidae, whose members are often called "small fruit flies" or (less frequently) pomace flies, vinegar flies, or wine flies, a reference to the characteristic of many species to linger around overripe or rotting fruit.)- https://en.wikipedia.org/wiki/DrosophilaThermogenics (tending to produce heat, and the term is commonly applied to drugs which increase heat through metabolic stimulation, or to microorganisms which create heat within organic waste.)- https://en.wikipedia.org/wiki/ThermogenicsMinori Chihara (Japanese voice actress and singer who has had roles in several anime series.)- https://en.wikipedia.org/wiki/Minori_ChiharaMinori Chihara - Violet Evergarden Gaiden Theme Song (R3 Music box version)- https://www.youtube.com/watch?v=TYO6DCHN-esFires continue to burn in Victoria despite wet weather- https://www.news.com.au/technology/environment/fires-continue-to-burn-in-victoria-despite-wet-weather/news-story/c2459b0fc47661ab0fd0f103311c0941That Guy with Glasses Indiegogo video- https://www.youtube.com/watch?v=8XXK9wByYYMCloud Imperium Releases $27,000 Legatus Pack for ‘Star Citizen’- https://variety.com/2018/gaming/news/star-citizen-27000-pack-1202825654/Star Citizen’s $27,000 bundle raises eyebrows- https://www.polygon.com/2018/5/30/17411226/star-citizen-legatus-pack-bundleStar Citizen Has a $27,000 Ship Pack- https://kotaku.com/star-citizen-now-has-a-27-000-ship-pack-1826404455?IR=TShips - Roberts Space Industries- https://robertsspaceindustries.com/pledge/shipsHackers slaughter thousands in 'World of Warcraft'- https://www.nbcnews.com/tech/tech-news/hackers-slaughter-thousands-world-warcraft-flna1C6337604Most expensive games to develop- https://en.wikipedia.org/wiki/List_of_most_expensive_video_games_to_developSoftware Developer Seeks To Delay Its Lawsuit Against Makers Of The $300 Million Game ‘Star Citizen’- https://www.forbes.com/sites/mattperez/2020/01/06/software-developer-seeks-to-delay-its-suit-against-makers-of-the-over-300-million-game-star-citizen/#382d6d4319ffHotline Miami- https://store.steampowered.com/app/219150/Hotline_Miami/Quakers Oats Company- https://en.wikipedia.org/wiki/Quaker_Oats_CompanyDick Tracy Original Watch (Indiegogo campaign)- https://www.indiegogo.com/projects/dick-tracy-the-official-watch--4#/Shoutouts12 Jan 2020 – Diego the 100-year-old Española giant tortoise who saved its species from extinction by fathering an upward of 800 offspring is heading for retirement in the Galapagos islands by being released from captivity and returning to the wild. - https://www.washingtonpost.com/science/2020/01/12/diego-tortoise-species-retiring/13 Jan 1928 - RCA and GE install three test television sets in homes in Schenectady, New York allowing American inventor E.F.W. Alexanderson to demonstrate the first home television receiver which delivered a poor and unsteady 1.5 square inch picture - https://www.onthisday.com/date/1928/january13 Jan 2020 - Infinity Ward, Activision & Bungie are donating 100% of the profits from the Outback cosmetic bundle to the Australian bushfire effort. - https://www.gamesindustry.biz/articles/2020-01-13-infinity-ward-bungie-and-ubisoft-join-australian-bushfire-relief-efforts13 Jan 2020 - Lucy the pink helicopter has been dragged from the drink after Armidale pilot Lachie Onslow dipped into a dam in the state's south coast. The aircraft was retrieved in a joint salvage operation by the Navy, Army and HAZMAT personnel. The helicopter dipped into the dam when it lost power while refilling it's waterbombing bucket to help fight the Clyde Mountain fire - https://www.armidaleexpress.com.au/story/6578541/australian-navy-and-army-drag-submerged-helicopter-from-the-drink/15 Jan 2020 – Christopher Tolkien passes away. He was the son of author J. R. R. Tolkien and the editor of much of his father's posthumously published work. Tolkien drew the original maps for his father's The Lord of the Rings. He died at the age of 95 in Draguignan,Var - https://en.wikipedia.org/wiki/Christopher_TolkienRemembrances7 Jan 2020 - Neil Ellwood Peart, Canadian musician and writer best known as the drummer and primary lyricist of the rock band Rush. Peart received numerous awards for his musical performances, including an induction into the Modern Drummer Readers Poll Hall of Fame in 1983, making him the youngest person ever so honoured. His drumming was renowned for its technical proficiency and his live performances for their exacting nature and stamina. In addition to serving as Rush's primary lyricist, Peart published several memoirs about his travels. His lyrics for Rush addressed universal themes and diverse subjects including science fiction, fantasy, and philosophy, as well as secular, humanitarian, and libertarian themes. Peart wrote a total of seven nonfiction books focused on his travels and personal stories. He died from glioblastoma, an aggressive form of brain cancer at the age of 67 in Santa Monica, California. - https://en.wikipedia.org/wiki/Neil_Peart13 Jan 1941 - James Augustine Aloysius Joyce, Irish novelist, short story writer, poet, teacher, and literary critic. He contributed to the modernist avant-garde and is regarded as one of the most influential and important authors of the 20th century. Joyce is best known for Ulysses, a landmark work in which the episodes of Homer's Odyssey are paralleled in a variety of literary styles, most famously stream of consciousness. Other well-known works are the short-story collection Dubliners, and the novels A Portrait of the Artist as a Young Man and Finnegans Wake. His other writings include three books of poetry, a play, his published letters and occasional journalism. He died from a perforated duodenal ulcer at the age of 58 in Zürich. - https://en.wikipedia.org/wiki/James_Joyce13 Jan 1691 - George Fox, English Dissenter, who was a founder of the Religious Society of Friends, commonly known as the Quakers or Friends. He rebelled against the religious and political authorities by proposing an unusual, uncompromising approach to the Christian faith. He travelled throughout Britain as a dissenting preacher, often being persecuted by the disapproving authorities. His ministry expanded and he made tours of North America and the Low Countries. He was arrested and jailed numerous times for his beliefs. He spent his final decade working in London to organize the expanding Quaker movement. Despite disdain from some Anglicans and Puritans, he was viewed with respect by the Quaker convert William Penn and the Lord Protector, Oliver Cromwell. He died from heart failure at the age of 66 in London. - https://en.wikipedia.org/wiki/George_FoxFamous Birthdays8 Jan 1947 - David Robert Jones known professionally as David Bowie, English singer-songwriter and actor. He was a leading figure in the music industry and is considered one of the most influential musicians of the 20th century, acclaimed by critics and musicians, particularly for his innovative work during the 1970s. His career was marked by reinvention and visual presentation, with his music and stagecraft having a significant impact on popular music. During his lifetime, his record sales, estimated at over 100 million records worldwide, made him one of the world's best-selling music artists. In the UK, he was awarded ten platinum album certifications, eleven gold and eight silver, and released eleven number-one albums. In the US, he received five platinum and nine gold certifications. He was inducted into the Rock and Roll Hall of Fame in 1996. On 8 January 2020, on what would have been Bowie's 73rd birthday, a previously unreleased version of the song "The Man Who Sold the World" was released, and two new releases were announced: a streaming-only EP entitled Is It Any Wonder? and a 9 track album entitled CHANGESNOWBOWIE, set to be released on Record Store Day 2020. He was born in Brixton, London - https://en.wikipedia.org/wiki/David_Bowie13 Jan 1960 - Eric Betzig, American physicist who works as a Professor of Physics and Professor Molecular and Cell biology at the University of California, Berkeley. He is also a Senior Fellow at the Janelia Farm Research Campus in Ashburn, Virginia. Betzig has worked to develop the field of fluorescence microscopy and photoactivated localization microscopy. He was awarded the 2014 Nobel Prize in Chemistry for "the development of super-resolved fluorescence microscopy" along with Stefan Hell and fellow Cornell alumnus William E. Moerner. He used this technique to study the division of cells in human embryos. He was born in Ann Arbor, Michigan - https://en.wikipedia.org/wiki/Eric_Betzig13 Jan 1990 - Liam Hemsworth, Australian actor. He played the roles of Josh Taylor in the soap opera Neighbours and Marcus in the children's television series The Elephant Princess. In American films, Hemsworth starred as Will Blakelee in The Last Song, as Gale Hawthorne in The Hunger Games film series, and as Jake Morrison in Independence Day: Resurgence. Hemsworth's older brothers, Luke and Chris, are also actors. He was born in Melbourne, Victoria - https://en.wikipedia.org/wiki/Liam_HemsworthEvents of Interest13 Jan 1879 – In Mozart Gardens Brooklyn Ada Anderson completed a great feat of pedestrianism - 2700 quarter miles in 2700 quarter hours, earning her $8000. The event was so popular that the spectator fee was raised from 25 cents to 50 cents after 5/6 of the event had been completed. By the final day of the event ticket prices were $1 for standing and $2 for reserved seating. She completed the event on 13 January 1879 to a venue so packed that police had to prevent additional spectators. Many of the spectators were women who it was reported regarded Anderson as 'the most wonderful of their sex' - https://en.wikipedia.org/wiki/Ada_Anderson13 Jan 1908 - Henri Farman becomes the first person to fly an observed circuit of more than 1km, winning the Grand Prix d'Aviation. For his efforts he won 50,000 francs. - https://www.onthisday.com/photos/henri-farman-wins-the-grand-prix-aviation13 Jan 1976 - American inventor Ray Kurzweil and the National Federation of the Blind unveil the Kurzweil Reading Machine, the first omni-font optical character recognition system. - http://www.historyofinformation.com/detail.php?id=1971IntroArtist – Goblins from MarsSong Title – Super Mario - Overworld Theme (GFM Trap Remix)Song Link - https://www.youtube.com/watch?v=-GNMe6kF0j0&index=4&list=PLHmTsVREU3Ar1AJWkimkl6Pux3R5PB-QJFollow us onFacebook- Page - https://www.facebook.com/NerdsAmalgamated/- Group - https://www.facebook.com/groups/440485136816406/Twitter - https://twitter.com/NAmalgamatedSpotify - https://open.spotify.com/show/6Nux69rftdBeeEXwD8GXrSiTunes - https://itunes.apple.com/au/podcast/top-shelf-nerds/id1347661094RSS - http://www.thatsnotcanonproductions.com/topshelfnerdspodcast?format=rssInstagram - https://www.instagram.com/nerds_amalgamated/General EnquiriesEmail - Nerds.Amalgamated@gmail.com

丽莎老师讲机器人之纳米级成像，人类终于看清大脑每个神经元欢迎收听丽莎老师讲机器人，想要孩子参加机器人竞赛、创意编程、创客竞赛的辅导，找丽莎老师！欢迎添加微信号：153 5359 2068，或搜索微信公众号：我最爱机器人。Science杂志最新封面报道，科学家们成功扫描了果蝇的完整大脑，达到了纳米级成像，将测绘速度提高了1000倍！有解读大脑的能力，科学家就可以追踪神经元之间的联系，从而破解大脑的奥秘。最新出版的Science杂志封面，报道了MIT和霍华德·休斯医学研究所（HHMI）科学家们的最新成果，他们成功对果蝇的完整大脑进行了成像，清晰度达到了纳米级，而且只用了不到三天时间！几十年来，神经科学家一直梦想绘制出一幅完整的大脑神经网络的精细地图，包括人脑、老鼠和果蝇的神经网络。有了这种能力，科学家就可以追踪神经元之间的联系，进而了解大脑是如何做出决定的。利用电子显微镜对果蝇大脑的神经元和突触进行全面测绘已经花费了10年的时间，数十人为此付出了努力。科学家们通过结合两种最先进的技术，膨胀显微镜(expansion microscopy)和晶格层光显微镜(lattice light-sheet microscope)，新的大脑测绘速度提高了1000倍。值得注意的是，发明了晶格层光显微术的Eric Betzig教授获得2014年诺贝尔化学奖，这次登上Science封面的论文，也有Eric Betzig的名字。论文的通讯作者MIT教授Edward S. Boyden五年前发明了膨胀显微镜，并在2018年获得了有诺贝尔风向标称号的加拿大盖尔德纳奖（Canada Gairdner International Award）。这篇论文堪称是两个顶级研究团队“珠帘合璧”的力作。纳米级观察大脑：4000万个突触一览无余电子显微镜一直是研究大脑的利器，这也是几代人努力之后探索出来的一条道路。不过，使用电子显微镜，需要花费多年的时间才能获得果蝇的大脑图像。Science最新一期的封面，介绍了一种新的大脑扫描技术，能让任何人看清果蝇大脑的4000万个突触，其中神经元相互连接。这项研究的里程碑意义在于，这张覆盖整个果蝇大脑的3D地图显示出直径只有60纳米的细节，而且只用了不到三天时间，果蝇大脑中不同的神经细胞，甚至蛋白质在空间上的相对分布都能够看到，这对基础科研意义重大。虽然其细节水平不如电子显微镜观察到的那么好，但通过计算突触，神经科学家可以判断神经连接的强度，比如那些负责记忆的神经连接。2014年获诺贝尔化学奖的Eric Betzig教授说，一天至少能扫描10个果蝇的大脑，这样的快速和高分辨率将促使科学家们提出新的问题，比如雄性和雌性果蝇的大脑有哪些差异，或者同种果蝇的大脑回路有什么差别。并且，这只是昆虫大脑复杂的网络连接的超分辨率视图，这些网络连接构成了从进食到交配的各种行为的基础，今后，扫描更高级生物的大脑，是不是可以期待一下呢？膨胀显微镜和晶格层光显微镜珠帘合璧之作MIT的Edward Boyden教授在五年前发明膨胀显微镜认为：“我们不仅仅是在逐步扫描更多的脑组织，我们是在扫描整个大脑。这就是我们如此兴奋的原因。”膨胀显微镜(ExM)的原理是将组织样本包埋在一种吸水膨胀的聚合物中，使得组织像气球一样膨胀，同时能保持内部结构的相对位置不变，然后用常规显微镜对大块脑组织进行了超高分辨率的蛋白质成像。它使用的是类似尿不湿里的聚丙烯酰胺凝胶，这种凝胶在从盐水转移到纯净水的过程中会膨胀。Betzig说：“（Boyden）他们2016年第一次来找我时，我还是充满怀疑的；我担心的是，首先，你是否可以使大脑组织这样的东西理想地膨胀，而不让它产生扭曲。然后我担心，尽管样品是透明的，它们还是会像玻璃球那样扭曲光线。”浏览果蝇大脑的高分辨率3D图像。这些彩色的球代表了大脑中神经元的一个子集上突触的密度，即那些对多巴胺有反应的神经元。这些彩色小球总共绘制了整个大脑的4000万个突触其中50万个突触的位置，红色表示突触密度最高，紫色表示突触密度最低。该联合研究团队由MIT Boyden实验室的博士后Ruixuan Gao和 Shoh Asano，以及哈佛医学院的Srigokul Upadhyayula带领，他们发现，在将脑组织膨胀4倍，体积增大到64倍后，它就几乎和水一样清澈，不会产生变形。很惊讶地发现，它的清晰度是如此完美，呈现出令人难以置信的光学均匀性。”结果，这种晶格层光显微镜能够在单个突触的水平上拍摄出一张非常详细且精确的大脑图像：分辨率达到约60纳米，仅为电子显微镜分辨率的十分之一。多色成像只需62.5小时。我们的征程是星辰大“脑”不过，Betzig预测，随着膨胀显微镜技术的改进——一些科学家已经能在每个方向将组织伸长25倍——这种结合技术在绘制大脑中所有神经连接方面可以取得几乎和电子显微镜一样好的结果。“如果你能让它在10倍或15倍的膨胀程度有效运作，科学家可能就会抛弃电子显微镜了。电子显微镜做密集神经跟踪也很好，但我们的技术要快得多，也便宜得多。我认为他们需要担心。尽管现在还不能取代电子显微镜，但在我看来，是有这种潜力的。”每一次完整的扫描，总计产生接近10TB的数据，然后由计算机组合成一个可以像视频游戏一样导航的3D图像。通过将荧光标记物附着到大脑中的蛋白质上，就有可能绘制出神经元和其他细胞的外膜、一个神经元与另一个神经元连接的突触、脑细胞的内部隔间，等等。这一研究为神经科学带来了极为重要的研究工具，帮助科学家们理解不同的神经环路如何组成，性别对大脑有怎样的影响，疾病又会怎样破坏大脑等等。研究团队不仅对果蝇的整个大脑进行了测试，还对老鼠大脑皮层上几毫米厚的一个薄片组织进行了测试，结果类似。人类的大脑有800亿个神经元，每个神经元可能有7000个突触，这或许是团队的新挑战。附Science杂志报道地址：http://science.sciencemag.org/content/363/6424/eaau8302

Nobel laureate Eric Betzig joined us to talk blue skies thinking, the benefits of naval gazing, open access, and why in science being risk averse can be the riskiest choice of all.

Produced in association with Caltech Academic Media Technologies. ©2016 California Institute of Technology

From Cornell to Bell Labs and beyond, Eric Betzig spent an entire career trying to see the unseeable. The optics of conventional microscopes face a fundamental, physical limit on their resolution. Dr. Betzig's quest to break this limit ultimately led to the development of a super-resolution microscopy technique, providing researchers a level of detail in biology and that had never been possible before. Misha, Ben and Joe sit down with him to discuss his incredible life story, and discover how a lauded physicist walked away from a promising career in science, only to return a decade later to achieve great scientific success that earned the 2014 Nobel Prize for Chemistry.

Este capítulo lo dedicamos a contaros el premio Nobel de Química del año 2014, que fue otorgado a Eric Betzig, Stefan Hell y William Moerner "por el desarrollo de la microscopía de fluorescencia con súper resolución". La historia de este Nobel es una de ésas en las que la ciencia rompe las barreras de lo posible: por las propiedades de la luz debería ser imposible ver detalles más pequeños que una fracción de una micra. Os contamos por qué, y os contamos cómo los ganadores del Nobel de Química 2014 lograron "saltarse" las limitaciones físicas de la luz y desarrollar microscopios con los que podemos ver detalles pequeñísimos en el interior de las células. Si os interesan las imágenes de objetos subcelulares os gustará el Nobel de Química de otro año, el de 2017: os lo contamos en el episodio s07e08. Este programa se emitió originalmente el 10 de octubre de 2014. Podéis escuchar el resto de audios de La Brújula en su canal de iVoox y en la web de Onda Cero, ondacero.es

Graduate students are uncertain about their career paths and Eric Betzig, 2014 Chemistry Nobel laureate gievs an insight into his transition from academia to industry, and back again. See acast.com/privacy for privacy and opt-out information.

Laureate Eric Betzig ignored the traditional boundaries of academic disciplines. He attributes his success to a background in industry. Should young scientists look outside of the university system to progress their careers?

Cambridge scientists are part of a resolution revolution. Building powerful instruments that shatter the physical limits of optical microscopy, they are beginning to watch molecular processes as they happen, and in three dimensions. Here, Professor Clemens Kaminski describes how a new era of super-resolution microscopy has begun. The developments earned inventors Eric Betzig and William E Moerner (USA) and Stefan Hell (Germany) the 2014 Nobel Prize for Chemistry, and are based on clever physical tricks that work around the problem of light diffraction. Among the scientists in Cambridge who are using the techniques, Kaminski’s team in the Department of Chemical Engineering and Biotechnology designs and builds super-resolution microscopes to study Alzheimer’s disease. “The technology is based on a conceptual change, a different way of thinking about how we resolve tiny structures. By imaging blobs of light as separate points in time, we are able to discriminate them spatially, and thus prevent image blur.” Their work is funded by the Medical Research Council, Wellcome Trust, Alzheimers Research UK, the Engineering and Physical Sciences Research Council and the Leverhulme Trust. http://www.youtube.com/subscription_center?add_user=cambridgeuniversity

This week on the on your mind neuroscience podcast:   We’re super excited to announce that we will be live-streaming the 2015 Sunposium: Neural Circuits and Sunshine, put on by the Max Planck Florida Institute for Neuroscience on Monday March 30 and Tuesday March 31!  There’s an impressive list of speakers, including Nobel Award winner Eric Betzig and in vivo memory manipulator Richard Tsien, who’s talks will be available for your viewing pleasure, live on this page.  We were able to get an interview with Dan Wilson, a graduate student at the Institute who studies synaptic dynamics in individual dendrites, which means you get a bonus weekend episode!  Of course it wouldn’t be an OYM episode if Liam and Kat didn’t talk about what’s on their minds, so we’ve got a lot of discussion going on about open sourcing the human body, the latest report to come out of the controversy over the Human Brain Project, and the possibility that neurons evolved twice! We hope you enjoy.   Get the stream and links to everything we talked about head to www.onyourmind.ca/sunposium2015

Eric Betzig hade inga planer på att ägna livet åt att vara forskare. Faktum är att han faktiskt sade upp sig efter att ha inlett en lovande forskarkarriär, trots det får han ett av årets Nobelpriser. Eric Betzig fick årets kemipris för att ha utvecklat mikroskop som gör det möjligt att se enskilda molekyler inuti celler, något som länge ansågs vara teoretiskt omöjligt. Men Betzig ser sig själv som fysiker och ingenjör, inte som kemist. Harn har för länge sedan tröttnat på det mikroskop han får priset för, och har precis blivit klar med att utveckla ett helt nytt. Nu håller han och hans fru, som också är forskare vid Janelia research campus utanför Washington, på att utveckla ytterligare en ny typ av mikroskopteknik. Den här gången inspirerade av hur teleskop kan se igenom tunna moln på himlen. Själv tror Eric Betzig att han nog kommer att tröttna på det också, och kanske lämna hela forskarvärlden igen. I programmet medverkar Eric Betzig, Nobelpristagare i kemi vid Janelia research campus och Harald Hess, fysikforskare, Janelia research campus Reporter: Torill Kornfeldt torill.kornfeldt@sverigesradio.se

We speak to Eric Betzig about his Nobel prize-winning research, and find out how thermoelectric materials can be made more efficient

123 - det man tänker innan man hoppar från tian i badhuset. Men 123 är också det antal avsnitt som hittills utkommit av din bästa podcast Kvack!. I det här avsnittet äter David organiska McNuggets, Frida pratar om hur Regina Lund verkligen lyft Falkenbergs FF och Henrik pratar om smååååå silverpartiklar. Dessutom: Svenska Podradiopriset 2014, Avengers, Dr. Oz, Ebola, Kollodialt Silver, Alzheimers, Benny Rosenqvist, Eric Betzig, Hover Boards, Bigfoot, Björn Söder, Katters rövhål och mycket, mycket mer! See acast.com/privacy for privacy and opt-out information.

The Nobel Prize in Physiology or Medicine 2014 was awarded with one half to John O'Keefe and the other half jointly to May-Britt Moser and Edvard I. Moser "for their discoveries of cells that constitute a positioning system in the brain".The Nobel Prize in Physics 2014 was awarded jointly to Isamu Akasaki, Hiroshi Amano and Shuji Nakamura "for the invention of efficient blue light-emitting diodes which has enabled bright and energy-saving white light sources".The Nobel Prize in Chemistry 2014 was awarded jointly to Eric Betzig, Stefan W. Hell and William E. Moerner "for the development of super-resolved fluorescence microscopy".A team of scientists took soil samples at 596 sites across New York's Central Park. They analysed the soil samples an discovered 167,000 different kinds of microbes, the vast majority of which were unknown to science.The characteristics of a previous mate can affect the attributes of a fruit fly's offspring. Even if the previous mate is not the genetic father of the offspring.Researchers at the Wake Forest Institute for Regenerative Medicine in Winston-Salem, North Carolina are developing artificial penises developed from a patient's own cells. The team is hoping to receive approval from the US FDA to begin human testing the lab-grown penises within five years.

A middle school in An’hui Province posted some brief words of congratulation in their campus to Eric Betzig, the American scientist who won the 2014 Nobel Prize in Chemistry, and called him “the son-in-law of our school” in the letter, just because Betzig’s wife Gina was graduated from this middle school. 由于诺贝尔化学奖得主的妻子毕业于安徽蚌埠一中，该中学在校园大屏幕上打出了“祝贺本校女婿获奖”的字样，引来网友纷纷揶揄“攀亲戚哪家强”。

Nobel Prizes 2014 The annual Nobel Prizes for Physiology or Medicine, Physics and Chemistry were announced this week. The Nobel Prize for Physiology or Medicine has been awarded to UK-based researcher Prof John O'Keefe as well as May-Britt Moser and Edvard Moser who discovered the brain's "GPS system". They discovered how the brain knows where we are and is able to navigate from one place to another. Their findings may help to explain why Alzheimer's disease patients cannot recognise their surroundings. The 2014 Nobel Prize for physics has been awarded to Professors Isamu Akasaki, Hiroshi Amano and Shuji Nakamura in Japan and the US, for the invention of blue light emitting diodes (LEDs). This enabled a new generation of bright, energy-efficient white lamps, as well as colour LED screens. The 2014 Nobel Prize in Chemistry has been awarded to Eric Betzig, Stefan Hell and William Moerner for improving the resolution of optical microscopes. This type of microscope had previously been held back by the presumed limitation that obtaining a better resolution than half the wavelength of light would be impossible. But the laureates used fluorescence to extend the limits of the light microscope, allowing scientists to see things at much higher levels of resolution. GAUGE The UK has a database for the amount of greenhouse gases we emit each year - usually measured in Gigatonnes of carbon. It's compiled by adding up emissions from various individual sources - be it a coal-fired power station or a wetland bog. This amount is used worldwide, but it is an estimate. A project called Greenhouse gas UK and Global Emissions, or GAUGE, is - for the first time - verifying these estimates by measuring what's in the atmosphere on a much larger scale. Genetics and Diabetes Type 2 diabetes is globally the fastest growing chronic disease. The World Health Organisation estimates more than 300 million people are currently afflicted, rising to more than half a billion by 2030. It might seem on the surface to be a disease with a simple cause - eat too much & exercise too little - and the basic foundation is a relative lack of the hormone insulin. But as with most illnesses, it's much more complicated, not least because a large number of disease processes are happening all at once. In 2010, a particular gene variant was associated with around 40% of Type 2 diabetics - not directly causal, but this so-called 'risk variant' increases the chance of developing the condition if you have the wrong lifestyle. Research published in the journal Science Translational Medicine this week identifies a drug called yohimbine as a potential treatment to help Type 2 diabetics, one that targets this specific genetic make-up. UK Fungus Day October 12th is UK Fungus Day, a chance for us to celebrate these cryptic, often microscopic, but essential organisms. Usually hidden away inside plants or in soil (or if you're unlucky, in between your toes), fungi have largely been growing below scientists' radars for centuries. Mycologists still don't know anything close to the true number of fungi that exist on the planet. About a hundred thousand have been formally identified, but it's estimated that anywhere from half a million to ten million species may exist. This dwarfs, by several orders of magnitude, how many mammals there are on Earth. And, increasingly, we're realising quite how crucial fungi are to the functioning of our ecosystems. Head of Mycology at The Royal Botanic Gardens Kew, Bryn Dentinger, explains how valuable fungi really are. Producer: Fiona Roberts Assistant Producer: Jen Whyntie.

Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy, which has enabled the study of single molecules in ongoing chemical reactions in living cells. Steve Mirsky reports  

Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy, which has enabled the study of single molecules in ongoing chemical reactions in living cells. Steve Mirsky reports  

The 2014 Nobel Prize in Chemistry is awarded to Eric Betzig, Stefan W. Hell and William E. Moerner for the development of super-resolved fluorescence microscopy. The winning work is explained by chemistry Nobel Committee members Sven Lidin and Måns Ehrenberg