Podcasts about hhmi

Eccentric billionaire Howard Hughes founded his eponymous Medical Institute over 70 years ago devoted to “unlocking the fundamentals of biology and building an open, inclusive future for science.”Some say Howard Hughes Medical Institute is bringing its founder's vision into the future with its one-of-a-kind Janelia Research Campus in Ashburn, Virginia. On this 281-acre parcel of land, integrated teams of lab scientists and tool-builders pursue a small number of scientific questions with potential for transformative impact. To drive science forward, they share their methods, results, and tools with the scientific community.Nelson Spruston, Ph.D., the executive director at HHMI's Janelia research campus, also tells hosts Mark Masselli and Margaret Flinter about AI@HHMI, its new $500 million initiative to embed AI systems throughout every stage of the scientific process.Spruston says, “Our approach is to identify people who have a very strong track record of making important discoveries in biomedical research and letting them pursue their best ideas without asking for our permission. What we're trying to do at HHMI is to use the deep bench of talent … to come up with ideas for problems [and address] long-standing open questions in the biological sciences.” Learn more about your ad choices. Visit podcastchoices.com/adchoicesSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode:00:45 An elusive, cosmic neutrino with a record-breaking energyAn enormous array of detectors, deep under the Mediterranean Sea, has captured evidence of the highest-energy neutrino particle ever recorded, although researchers aren't sure exactly where in the cosmos it originated. Calculations revealed this particle had over 30 times the energy of previously detected neutrinos. The team hopes that further study and future detections will help reveal the secrets of high-energy phenomena like supernovae.Research Article: The KM3NeT Collaboration11:34 Research HighlightsHow bonobos adjust their communication to account for what other individuals know, and the discovery of a huge collection of beads adorning the attire of the powerful Copper Age women in Spain.Research Highlight: Bonobos know when you're in the know ― and when you're notResearch Highlight: Record-setting trove of buried beads speaks to power of ancient women14:15 US judge puts NIH grant cuts on holdA judge has blocked a policy that would have slashed billions of dollars of funding for US research institutions, which come as part of President Donald Trump's controversial crackdown on government spending. We discuss the reasoning behind the proposed cuts and the impacts they may have if enacted. We also look at the effects that President Trump's executive orders targeting diversity, equity and inclusion (DEI) policies and funding are having across the US.Nature: ‘Devastating' cuts to NIH grants by Trump's team put on hold by US judgeNature: Have Trump's anti-DEI orders hit private funders? HHMI halts inclusive science programmeNature: Scientists globally are racing to save vital health databases taken down amid Trump chaos25:50 Briefing ChatWhy the latest odds on asteroid 2024 YR4's chance of impacting Earth are so hard to calculate, and how the latest version of DeepMind's AlphaGeometry AI has reached the gold-medal level in geometry.New York Times: Why the Odds of an Asteroid Striking Earth in 2032 Keep Going Up (and Down)Nature: DeepMind AI crushes tough maths problems on par with top human solversSubscribe to Nature Briefing, an unmissable daily round-up of science news, opinion and analysis free in your inbox every weekday. Hosted on Acast. See acast.com/privacy for more information.

研究領域物換星移，隨著新的研究領域誕生，也有研究領域慢慢淡出人們的視野。而有些曾經冷門的領域，則因為技術進步、新的科學發現，回歸眾人追逐的研究熱點。神經膠質細胞（Neural progenitor cells, NPCs）就是這樣的領域，隨著近年對神經退化疾病的重視，以及全基因組關聯研究（GWAS）的發現指引，原本被認為扮演輔助角色的神經膠質細胞，一躍成為熱門的藥物標的。 本集的訪談邀請到蔡蕙歆博士，他將會介紹神經膠質細胞在神經系統的功能，以及這一群「和神經細胞一樣重要」的細胞，在神經退化疾病領域的進展。此外，蕙歆也會和我們分享他如何轉換領域、挑戰自我，從學界教職跳到業界，從基礎研究進到臨床試驗開發。他也和我們分享管理腦庫的特別經歷、和面對公司人事異動、冷門領域找工作的心法。他談論如何調適心態，應對多變的環境，在職涯中展現的彈性和適應力。相信蕙歆的分享，對於現在面臨嚴峻景氣的求職者，與在職場打拼探索屬於自己的道路的大家，會非常有助益。  

Welcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Things I learned talking to the new breed of scientific institution, published by Abhishaike Mahajan on August 30, 2024 on LessWrong. Note: this article is sponsored by and cross-posted to the Good Science Project. They also write a fair bit, and their articles were essential reading for writing this essay! Also, this article would not be possible without the hours of discussion/editing help I've had with several people from these institutions, and a few outside of them. Huge shout-out to all of them! Introduction Arcadia Science, Speculative Technologies, FutureHouse, Arc, and Convergent. All of these are a new form of scientific institute. Most are funded entirely by a few billionaires. Most are non-profits. Most of them focus on the life-sciences. Most of them have sprung up in just the last few years. They do all also have one common thread: a grand statement. We are an experiment in a new way to do science. And they are! Traditionally, research is conducted in academic or private industry labs - dependent on NIH grants in the former and markets in the latter. Given the (often singular) sources of no-strings-attached funding, these new institutions need not satisfy either the NIH or the markets, allowing them to conduct research in a unique fashion. In one sense, the experimental aspect of these institutions revolves around the focus of the research itself, addressing fields or using methods that the founders - correctly or not - view as underserved/underutilized. But, on a more subtle level, the experimental aspect could be more closely tied to the culture of these organizations. Institutions like Arcadia, FutureHouse, and the rest could be viewed as the production of auteurs - a term from filmmaking for films with such a heavy sense of the director's personal taste that the film is inseparable from the director. This is where the novelty within these institutions primarily lie, in how the founders of the institute wish science was conducted. And wielding billions of dollars, thousands of hours of work, and hundreds of scientists as a means to test whether their theories are correct. Of course, nothing under the sun is truly new. There is an age-old history of scientist dissatisfaction with how 'things are traditionally done', and confidently building new institutions to solve the problems they've seen. Many of these are now household names amongst researchers: Broad Institute, Whitehead Institute, Max Planck Society, Howard Hughes Medical Institute (HHMI), and so on. Each of these were started with similar contrarian mentalities as the current era of institutions. Some of these were more experimental than others, most notably HHMI, which prized itself on its focus on interdisciplinary research above all else. But all were experiments, many of them extraordinarily successful. Yet, the current iteration of new research institutes is still arguably more experimental than its ancestors. While the last generation of institutes was typically tied directly to universities, the current era of ones (outside of Arc) are independent, allowing them a larger sense of opinionation on how science should be done. But, despite this experimentation, there is relatively little information out there on what's going on inside them. Not in terms of science, but more-so the vibes. While aspects of these organizations have been written about previously, such as in articles in The Atlantic and Endpoints, they aren't assessing vibes! These other articles are, first and foremost, news-pieces; valuable, but lack any opinionated observations on the inner-workings of the institutions. Nadia Asparouhova's essay on the subject comes closest to this regarding the history of these institutions, but still few details on how they practically function. This essay attempts to discuss that missing s...

Link to original articleWelcome to The Nonlinear Library, where we use Text-to-Speech software to convert the best writing from the Rationalist and EA communities into audio. This is: Things I learned talking to the new breed of scientific institution, published by Abhishaike Mahajan on August 30, 2024 on LessWrong. Note: this article is sponsored by and cross-posted to the Good Science Project. They also write a fair bit, and their articles were essential reading for writing this essay! Also, this article would not be possible without the hours of discussion/editing help I've had with several people from these institutions, and a few outside of them. Huge shout-out to all of them! Introduction Arcadia Science, Speculative Technologies, FutureHouse, Arc, and Convergent. All of these are a new form of scientific institute. Most are funded entirely by a few billionaires. Most are non-profits. Most of them focus on the life-sciences. Most of them have sprung up in just the last few years. They do all also have one common thread: a grand statement. We are an experiment in a new way to do science. And they are! Traditionally, research is conducted in academic or private industry labs - dependent on NIH grants in the former and markets in the latter. Given the (often singular) sources of no-strings-attached funding, these new institutions need not satisfy either the NIH or the markets, allowing them to conduct research in a unique fashion. In one sense, the experimental aspect of these institutions revolves around the focus of the research itself, addressing fields or using methods that the founders - correctly or not - view as underserved/underutilized. But, on a more subtle level, the experimental aspect could be more closely tied to the culture of these organizations. Institutions like Arcadia, FutureHouse, and the rest could be viewed as the production of auteurs - a term from filmmaking for films with such a heavy sense of the director's personal taste that the film is inseparable from the director. This is where the novelty within these institutions primarily lie, in how the founders of the institute wish science was conducted. And wielding billions of dollars, thousands of hours of work, and hundreds of scientists as a means to test whether their theories are correct. Of course, nothing under the sun is truly new. There is an age-old history of scientist dissatisfaction with how 'things are traditionally done', and confidently building new institutions to solve the problems they've seen. Many of these are now household names amongst researchers: Broad Institute, Whitehead Institute, Max Planck Society, Howard Hughes Medical Institute (HHMI), and so on. Each of these were started with similar contrarian mentalities as the current era of institutions. Some of these were more experimental than others, most notably HHMI, which prized itself on its focus on interdisciplinary research above all else. But all were experiments, many of them extraordinarily successful. Yet, the current iteration of new research institutes is still arguably more experimental than its ancestors. While the last generation of institutes was typically tied directly to universities, the current era of ones (outside of Arc) are independent, allowing them a larger sense of opinionation on how science should be done. But, despite this experimentation, there is relatively little information out there on what's going on inside them. Not in terms of science, but more-so the vibes. While aspects of these organizations have been written about previously, such as in articles in The Atlantic and Endpoints, they aren't assessing vibes! These other articles are, first and foremost, news-pieces; valuable, but lack any opinionated observations on the inner-workings of the institutions. Nadia Asparouhova's essay on the subject comes closest to this regarding the history of these institutions, but still few details on how they practically function. This essay attempts to discuss that missing s...

In this episode of the Back of the Napkin, we dive into the world of fluorescence imaging with Luke Lavis. Known for his pioneering work at the Janelia Research Campus, Luke shares his unique journey from the woods of Oregon to the chemistry lab. Luke's story illustrates how diverse experiences can lead to groundbreaking scientific achievements.Discover how Luke's work has pushed the boundaries of fluorescence imaging. Notably, his development of Janelia Fluor® dyes has significantly improved live-cell and super-resolution imaging capabilities. This episode reveals the intricate balance between fundamental research, application in drug discovery, and the collaborative culture at Janelia, emphasizing the importance of mentorship and interdisciplinary interactions.- Follow Luke on X: @rhodamine110- Explore the Janelia Research Campus's Open Chemistry initiative for pre-commercial compounds: dyes.janelia.org- Learn more about HHMI and the Janelia Research Campus: HHMI Janelia- Janelia Fluor(R) dyes for super-resolution microscopy available at Bio-Techne Janelia Fluor® Dyes for Super Resolution Microscopy | Bio-Techne- Follow Alex: @MoloneyAlex

In this episode, Xavier Bonilla has a dialogue with Thomas Cech about RNA as a major catalyst in organic systems. They discuss why RNA does not get discussed as much as DNA, basics of DNA, RNA as a catalyst, and the splicing capabilities of RNA. They also talk about transcription, translation, and splicing, RNA as internal catalyst and external catalyst, and the origins of life. They talk about telomeres and extended life, different types of RNA, mRNA vaccines, CRISPR, and many more topics. Thomas Cech is distinguished professor of chemistry and biochemistry at the University of Colorado-Boulder. He has been an Investigator at the Howard Hughes Medical Institute (HHMI) since 1988 and was President of HHMI in 2000-2009. He has his PhD from the University of California-Berkeley and completed his postdoctorate at MIT. His main interests are in RNA and telomeres. He received the Nobel Prize in Chemistry (with Sidney Altman) in 1989 and the National Medal of Science in 1995. He is the author of the latest book, The Catalyst: RNA and the Quest to Unlock Life's Deepest Secrets. Get full access to Converging Dialogues at convergingdialogues.substack.com/subscribe

Dr. Lin Tian is a Scientific Director at the Max Planck Florida Institute for Neuroscience and Clinical Professor at the University of California, Davis. The main goal of Lin's lab is to develop, leverage, and also share novel optical and molecular tools that can help us to characterize neural signaling and find new treatment targets for neuropsychiatric disorders. In addition to her scientific and leadership roles, Lin is a mom, wife, and daughter. She often spends her free time with her family, driving her two sons to different activities, cheering for them at their swim meets and baseball games, and helping them with homework. Lin also enjoys walking her dog and doing things around the house. She earned her B.S. in Neuroscience from the University of Science and Technology of China and her Ph.D. in Biochemistry, Molecular, and Cellular Biology from Northwestern University. She then completed postdoctoral training at Howard Hughes Medical Institute's Janelia Research Campus. Lin remained at HHMI as a Research Specialist before joining the faculty at the University of California, Davis School of Medicine in 2012. She began her current position at Max Planck in 2023. Lin has received multiple awards and honors, including an NIH New Innovator Award, the W.M. Keck Foundation Award, the Human Frontier Science Program Young Investigator Award, and she has been named a Rita Allen Scholar and Hartwell Scholar. In our interview, she shares more about her life and science.

Dr. Marissa Scavuzzo is an HHMI Hanna H. Gray Fellow at Case Western Reserve University School of Medicine. Her research focuses on enteric glia regulation in the healthy and diseased gut. She talks about how glial cell subtypes affect intestinal motility and her experience receiving NYSCF and HHMI fellowships. She also talks about bringing science to underserved schools in Cleveland.

Each month, our Carrier Connections program features a different X-linked condition with the goal to increase awareness and education of X-linked conditions and how they impact females. This month, we are featuring Kennedy's disease. Kennedy's disease is an X-linked disorder characterized by muscle weakness and wasting that typically manifests in adulthood. It is caused by a mutation in the AR gene, which is responsible for encoding a protein called an androgen receptor. Studies show that some female carriers may experience muscle weakness and neurodegeneration. Today, we are joined by Dr. Christopher Grunseich, M.D. Dr. Chris Grunseich is a Staff Clinician in the Neurogenetics Branch, NINDS. He completed his undergraduate studies at Brown University, and went on to receive his M.D. from SUNY Stony Brook School of Medicine in 2006. While at SUNY Stony Brook he completed an HHMI research fellowship year working in the laboratory of Dr. Gail Mandel. He then completed medical internship at St. Vincent's Hospital, and his residency training in neurology at Georgetown University. He joined Dr. Kenneth Fischbeck's research group as a neurogenetics fellow, and has been a Staff Clinician since 2016. He is board certified in Neurology. His research focuses on clinical studies of patients with motor neuron disease and using patient-derived cell models to better understand the biology of motor neuron diseases. Carrier Connections is sponsored by Horizon Therapeutics, Sanofi, and Ultragenyx Pharmaceutical. For more information about our organization, check out ⁠⁠⁠rememberthegirls.org⁠⁠⁠.

  For the first time ever, parents going through IVF can use whole genome sequencing to screen their embryos for hundreds of conditions. Harness the power of genetics to keep your family safe, with Orchid. Check them out at orchidhealth.com. We're about a generation into the “age of genomics,” or as it's sometimes termed the “post-genomic era.” Today Razib talks to John Logsdon, a professor of biology at the University of Iowa, about what genomics has wrought in relation to our understanding of evolution, and what evolution has taught us about the structure and nature of the genome. In 2014, Logdson and Sarah J Hanson contributed a chapter entitled “Genome Evolution” to the Princeton Guide to Evolution. Razib uses this mid-2010s review to scaffold his discussion with Logdson about where we are in 2023. But first, he asks what the exact difference between genetics and genomics is. It is sometimes said that quantity has a quality all its own, and Razib and Logdson discuss the different analytic challenges of analyzing the evolutionary trajectory of a single gene, a task up the alley of classical genetics, and describing the evolution of the whole genome of an organism like a human, with thousands of genes. They then move on to various issues relating to the architecture and evolution of the genome that are of deep interest and curiosity to researchers but rarely surfaced to the public. Why do bacterial genomes have so much less “junk” than those of complex organisms, like humans? Why is the relationship between organism complexity and genome size still so uncertain? How has evolution impacted the “molecular machinery” of the genome (like promoters)? And what is the difference between those scientists who use genomics to understand evolution and those who attempt to understand the evolutionary forces that shape the nature of the genome? By inspecting where we are on many specific issues relating to evolution and genomics, Razib and Logdson begin a sketch of how the emergence of genomics has changed evolutionary biology, as the entire genetic maps of vast numbers of species are now at our fingertips. The discussion finally concludes with future possibilities in the next few decades, as the post-genomic era moves from a revolution to a background condition, a  banality. Note: Logsdon mentioned HHMI molecular genetic videos. Here is an excellent example:

This episode is sponsored by Celonis ,the global leader in process mining. AI has landed and enterprises are adapting. To give customers slick experiences and teams the technology to deliver. The road is long, but you're closer than you think. Your business processes run through systems. Creating data at every step. Celonis recontrusts this data to generate Process Intelligence. A common business language. So AI knows how your business flows. Across every department, every system and every process. With AI solutions powered by Celonis enterprises get faster, more accurate insights. A new level of automation potential. And a step change in productivity, performance and customer satisfaction Process Intelligence is the missing piece in the AI Enabled tech stack. Go to https:/celonis.com/eyeonai to find out more. Welcome to episode 146 of the Eye on AI podcast. In this episode, host Craig Smith sits down with Viren Jain, a leading Research Scientist at Google in Mountain View, California. Viren, at the helm of the Connectomics team, has pioneered breakthroughs in synapse-resolution brain mapping in collaboration with esteemed institutions such as HHMI, Max Planck, and Harvard.   The conversation kicks off with Jain introducing his academic journey and the evolution of connectomics – the comprehensive study of neural connections in the brain. The duo delves deep into the challenges and advancements in imaging technologies, comparing their progression to genome sequencing. Craig probes further, inquiring about shared principles across organisms, the dynamic behavior of the brain, and the role of electron microscopes in understanding neural structures.   The dialogue also touches upon Google's role in the research, Jain's collaborative ventures, and the potential future of AI and connectomics. Viren also shares his insights into neuron tracing, the significance of combining algorithm predictions, the zebra finch bird's song-learning mechanism, and the broader goal of enhancing human health and medicine.   Craig Smith Twitter: https://twitter.com/craigss Eye on A.I. Twitter: https://twitter.com/EyeOn_AI (00:00) Preview, Introduction and Celonis (06:45) Viren's Academic and Professional Journey (13:17) AI's Technological Progress and Challenges (22:20) Deep Dive into Connectomics (39:20) Google's Role in AI (44:16) Natural Learning vs. AI Algorithms (57:32) Brain Mapping: Present and Future (01:00:33) Brain Studies for Medical Advancement (01:06:05) Final Reflections and Celonis ad  

The fourth Season of the National Institute of Neurological Disorders and Stroke's Building Up the Nerve podcast, where we discuss the unwritten rules, or “hidden curriculum,” of scientific research at every career stage. We know that navigating your career can be daunting, but we're here to help—it's our job!In episode 8, we talk about succeeding as junior faculty, including starting a lab from scratch, balancing all aspects of the job, and how to manage tenure expectations.Featuring Ishmail Abdus-Saboor, PhD, Assistant Professor, Columbia University; Katie Wilkinson, PhD, Professor, San Jose State University; and Jack Lipton, PhD, Professor, Michigan State University.ResourcesMaximizing Investigators' Research Award (MIRA) (R35): https://nigms.nih.gov/Research/mechanisms/MIRA Resources from the 2022 “Maintaining a Neural Network: Transforming Mentorship Workshop”: https://www.ninds.nih.gov/news-events/events/maintaining-neural-network-transforming-mentorship-workshop NIH Glossary: https://grants.nih.gov/grants/glossary.htm NIH Early Stage Investigator Resources: https://grants.nih.gov/policy/early-stage/index.htm Support for Research Excellence (SuRE): https://www.ninds.nih.gov/funding/about-funding/types-research-support/research-project-grants/support-research-excellence-sure-program-r16 NIH Research Enhancement Award (R15): https://grants.nih.gov/grants/funding/r15.htm University of Washington BRAINS program: https://brains.uw.edu/ Big 10 Academic Alliance: https://btaa.org/ Diversity R01 for New and “At-Risk” Investigators: https://www.ninds.nih.gov/funding/about-funding/types-research-support/research-project-grants/diversity-r01-new-and-risk-investigators Books:At the Helm: Leading your Laboratory by Kathy Barker Making the Right Moves: A Practical Guide to Scientific Management for Postdocs and New Faculty, Second Edition from HHMI: https://www.hhmi.org/science-education/programs/resources/making-right-moves  The Grant Application Writer's Workbook for NIH: https://www.grantcentral.com/workbooks/national-institutes-of-health/ Transcript available at http://ninds.buzzsprout.com/.

Luke Lavis is a senior group leader and head of molecular tools and imaging at HHMI's Janelia Research Campus. Luke Lavis works at the interface of chemistry and biology, developing small-molecule fluorescent dyes to illuminate biological samples. Lavis and his team use modern organic chemistry to design and synthesize bright fluorescent labels for imaging structures inside living cells. By combining these novel compounds with advances in instrumentation, protein engineering, and genetic manipulation, the Lavis Lab and their collaborators devise sophisticated bioimaging experiments at different scales ranging from tracking single molecules to measuring neural activity in cells and animals. “I sometimes call Luke our secret weapon here. Every advance I've made in my career has been due to fluorescent probes.” - Eric Betzig, Nobel Prize Laureate in Chemistry for 2014

Dr. David R. Liu is the Richard Merkin Professor and Director of the Merkin Institute of Transformative Technologies in Healthcare, vice-chair of the faculty at the Broad Institute of MIT and Harvard, the Thomas Dudley Cabot Professor of the Natural Sciences at Harvard University, and a Howard Hughes Medical Institute (HHMI) investigator. In addition, he is the founder or co-founder of several biotechnology and therapeutics companies, including Beam Therapeutics, Prime Medicine, Editas Medicine, Pairwise Plants, Exo Therapeutics, Chroma Medicine, Resonance Medicine, and Nvelop Therapeutics. David's research integrates components of biological evolution with chemistry to enable the development of new types of therapeutics and to better study biology. Through chemistry, they can change the structure of a molecule in order to change its function in anticipated ways. They also harness the power of cycles of natural selection to evolve molecules with desired tailor-made properties. Outside of science, David's hobbies include photography, making wooden vessels using a wood lathe, growing bonsai trees, and exploring electronic art and other homemade art projects. He enjoys blending creativity and intellectual pursuits to create something surprising and beautiful. He completed his undergraduate education at Harvard College, majoring in chemistry. He was awarded his PhD in organic chemistry from UC Berkeley, and he joined the faculty at Harvard University afterwards. He has been an HHMI investigator since 2005. Over the course of his career, David has received numerous awards and accolades, including being named the 2022 King Faisal Prize Laureate in Medicine and receipt of the Ronald Breslow Award for Biomimetic Chemistry, the American Chemical Society David Perlman Award, ACS Chemical Biology Award, the American Chemical Society Pure Chemistry Award, the Arthur Cope Young Scholar Award, and other prestigious awards for his research and teaching. In 2016 and 2020, he was named one of the Top 20 Translational Researchers in the world by Nature Biotechnology, and he was named one of Nature's 10 researchers in 2022. In addition, he is an elected Member of the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the American Association for the Advancement of Science. In this interview, David shares more about his life and science.

Today we're excited to have Dr. Mo Jain, CEO of Sapient. Dr. Jain or Mo as he prefers to be called is a physician-scientist with nearly 20 years of expertise in physiology, biomedicine, engineering, computational biology, and mass spectrometry-based metabolomics. Sapient is one of the largest capacity biomarker discovery labs in the world and well on its way to transform biomedicine forever. For all of our science and bio nerds, you'll sure be fascinated by the insights from Mo. https://sapient.bio/  About Mo Jain - Dr. Jain is a physician-scientist with nearly 20 years of expertise in physiology, biomedicine, engineering, computational biology, and mass spectrometry-based metabolomics. Prior to founding Sapient, he formed and was director of Jain Laboratory at the University of California San Diego (UCSD). There he led a multi-disciplinary research team of chemists, engineers, mathematicians, epidemiologists, and physicians to develop next-generation rapid liquid chromatography-mass spectrometry (rLC-MS) systems to probe the non-genetic landscape of disease across population-scale human studies. His work was supported by the National Institutes of Health Outstanding New Environmental Scientist (ONES) Program grant and over $30M in federal, foundation, and industry funding. Dr. Jain founded Sapient in 2021 as a spinout of Jain Laboratory to expand upon the mission of accelerating human discovery and drug development through the nexus of high throughput analytical mass spectrometry, computational biology, and population-scale clinical studies. As CEO, he develops and directs the organization's strategy and guides Sapient's scientific, business, and technical operations. Dr. Jain has held faculty positions at UCSD since 2013, most currently as a Professor of Medicine and Pharmacology. He obtained his MD and PhD from Boston University School of Medicine, and subsequently performed clinical residency and fellowship training in Internal Medicine, Cardiology, and Preventative Cardiology at Brigham and Women's Hospital, Harvard Medical School. His postdoctoral work was performed at the Broad Institute and Massachusetts General Hospital in the HHMI laboratory, developing methods for large scale, mass spectrometry-based metabolomics and integrative computational analysis to define the role of bioactive metabolites in human disease.https://www.linkedin.com/in/mo-jain-md-phd-373895ba/ Qualio website:https://www.qualio.com/ Previous episodes:https://www.qualio.com/from-lab-to-launch-podcast Apply to be on the show:https://forms.gle/uUH2YtCFxJHrVGeL8 Music by keldez

Adam Hyde is the founder and Manager of the not-for-profit Coko Foundation (San Francisco). Coko develops open-source publishing systems primarily for, but not restricted to, scholarly communications. Coko has developed bespoke publishing systems for organisations including NCBI, HHMI, Caltech, The Organisation for Human Brain Mapping, eLife, the Open Education Network, as well as several community products. Adam joins Jo to discuss on how to build sustainable infrastructure. Explore all our episodes at access2perspectives.org/conversations Host: Dr Jo Havemann, ORCID iD 0000-0002-6157-1494 Editing: Ebuka Ezeike Music: Alex Lustig, produced by Kitty Kat License: Attribution 4.0 International (CC BY 4.0) At Access 2 Perspectives, we guide you in your complete research workflow toward state-of-the-art research practices and in full compliance with funding and publishing requirements. Leverage your research projects to higher efficiency and increased collaboration opportunities while fostering your explorative spirit and joy. Website: access2perspectives.org --- Send in a voice message: https://podcasters.spotify.com/pod/show/access2perspectives/message

In this week's episode, both our storytellers explore the divisions and limits that influence how we understand and operate in the world and in science. Part 1: César Nufio's childhood experience as a Guatamalan immigrant shapes his life in science. Part 2: Seeking acceptance as a child of Kurdish immigrants in Denmark, Cansu Karabiyik decides to become a scientist. César Nufio is a scientist and educator who is passionate about understanding the natural world and working to increase diversity and inclusion in the sciences. He is currently a multimedia content developer at HHMI's BioInteractive where he works with artists, educators, filmmakers, and scientists to help engage and inspire students. Previously, he taught tropical biology courses for the Organization for Tropical Studies and explored the effect of climate change on insects in the Rocky Mountains while working at the University of Colorado Museum of Natural History. Coming to this country as an undocumented child and experiencing the generosity given by so many during his journey has impacted his commitment to giving back and his Latin American identity. Cansu Karabiyik is a neuroscientist at Columbia University. She was born in Denmark to Kurdish immigrants. In 2013, she moved to California for her studies in Biomedical Science and decided to never go back. She moved instead to Portugal to conduct the research for her Master thesis focusing on neuroprotection during stroke. In 2021, she completed her PhD at University of Cambridge in the UK focusing on neurodegeneration and has since been in NYC, where she spends her days in the lab researching molecular mechanisms of neuropsychiatric diseases and her evenings doing comedy across the city. Learn more about your ad choices. Visit podcastchoices.com/adchoices

#47 — From an early start in the lab at just 14 years old, to running one of the largest neuroscience groups in the world, Ed Boyden is a Professor and group leader in the Departments of Brain and Cognitive Sciences at MIT, and an HHMI investigator.  In this episode, we hear all about how despite his recent awards and huge success, he initially struggled to get a permanent role in academia, and how he believes you can help create your own luck in science.Watch or Listen to all episodes of The Microscopists here: https://themicroscopists.bitesizebio.com/

#47 — From an early start in the lab at just 14 years old, to running one of the largest neuroscience groups in the world, Ed Boyden is a Professor and group leader in the Departments of Brain and Cognitive Sciences at MIT, and an HHMI investigator. In this episode, we hear all about how despite his recent awards and huge success, he initially struggled to get a permanent role in academia, and how he believes you can help create your own luck in science. Browse all The Microscopists episodes here: http://bit.ly/the-microscopists-yt #TheMicroscopists #imaging #Expansionmicroscopy

------------------Support the channel------------ Patreon: https://www.patreon.com/thedissenter PayPal: paypal.me/thedissenter PayPal Subscription 1 Dollar: https://tinyurl.com/yb3acuuy PayPal Subscription 3 Dollars: https://tinyurl.com/ybn6bg9l PayPal Subscription 5 Dollars: https://tinyurl.com/ycmr9gpz PayPal Subscription 10 Dollars: https://tinyurl.com/y9r3fc9m PayPal Subscription 20 Dollars: https://tinyurl.com/y95uvkao ------------------Follow me on--------------------- Facebook: https://www.facebook.com/thedissenteryt/ Twitter: https://twitter.com/TheDissenterYT This show is sponsored by Enlites, Learning & Development done differently. Check the website here: http://enlites.com/ Dr. Sean Carroll is Balo-Simon Professor and Endowed Chair of Biology at the University of Maryland. He is also Professor Emeritus of Genetics and Molecular Biology at the University of Wisconsin–Madison. Dr. Carroll was an HHMI investigator from 1990 to 2010. In September 2010, he became vice president for science education at HHMI. He is the author of several books, including A Series of Fortunate Events: Chance and the Making of the Planet, Life, and You. In this episode, we focus on A Series of Fortunate Events. Topics include: chance and contingency; life as an improbable event; factors behind geological transitions; resilience in hominin evolution; mutation, natural selection, and their relative contribution to invention; speciation, and how species evolve; chance in human reproduction; cancer; and the philosophical and theological implications of chance. -- A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: KARIN LIETZCKE, ANN BLANCHETTE, PER HELGE LARSEN, LAU GUERREIRO, JERRY MULLER, HANS FREDRIK SUNDE, BERNARDO SEIXAS, HERBERT GINTIS, RUTGER VOS, RICARDO VLADIMIRO, CRAIG HEALY, OLAF ALEX, PHILIP KURIAN, JONATHAN VISSER, JAKOB KLINKBY, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, JOHN CONNORS, PAULINA BARREN, FILIP FORS CONNOLLY, DAN DEMETRIOU, ROBERT WINDHAGER, RUI INACIO, ARTHUR KOH, ZOOP, MARCO NEVES, COLIN HOLBROOK, SUSAN PINKER, PABLO SANTURBANO, SIMON COLUMBUS, PHIL KAVANAGH, JORGE ESPINHA, CORY CLARK, MARK BLYTH, ROBERTO INGUANZO, MIKKEL STORMYR, ERIC NEURMANN, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, BERNARD HUGUENEY, ALEXANDER DANNBAUER, FERGAL CUSSEN, YEVHEN BODRENKO, HAL HERZOG, NUNO MACHADO, DON ROSS, JONATHAN LEIBRANT, JOÃO LINHARES, OZLEM BULUT, NATHAN NGUYEN, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, J.W., JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, IDAN SOLON, ROMAIN ROCH, DMITRY GRIGORYEV, TOM ROTH, DIEGO LONDOÑO CORREA, YANICK PUNTER, ADANER USMANI, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, AL ORTIZ, NELLEKE BAK, KATHRINE AND PATRICK TOBIN, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, NICK GOLDEN, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, EDWARD HALL, HEDIN BRØNNER, DOUGLAS P. FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, DENISE COOK, SCOTT, ZACHARY FISH, TIM DUFFY, AND TRADERINNYC! A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, IAN GILLIGAN, LUIS CAYETANO, TOM VANEGDOM, CURTIS DIXON, BENEDIKT MUELLER, VEGA GIDEY, THOMAS TRUMBLE, AND NUNO ELDER! AND TO MY EXECUTIVE PRODUCERS, MICHAL RUSIECKI, ROSEY, JAMES PRATT, MATTHEW LAVENDER, SERGIU CODREANU, AND BOGDAN KANIVETS!

Today, our guest is Dr. Tammy, Adair, Senior Lecturer in biology and Director of course based undergraduate research in biology, and director of Baylor's undergraduate research and scholarly achievement program known as URSA. Doctor Adair also teaches course based undergraduate research experience labs, such as the phage lab sponsored by HHMI and the Science Education Alliance. Her undergraduate researcher group, the M&M bears focuses on microbial genomics. We are delighted to have Dr. Adair on the show to discuss active and then experiential learning in STEM education and undergraduate research across the academy.

#39 — Ever wondered just what it's like working at the HHMI Janelia Research Campus? Teng-Leong Chew, Director of the Advanced Imaging Center at Janelia, joins Peter O'Toole for episode #39 of The Microscopists to let us know. We'll also discover what it was like moving from Malaysia to Wisconsin during a blizzard-enforced University of Wisconsin shutdown, and hear more about street art and unexpected violin recitals. We'll learn about the challenges that Chew has faced in his career, as well as the highlights, and hear why Chew is so passionate about equitable access to microscopy technology.Watch or Listen to all episodes of The Microscopists here: https://themicroscopists.bitesizebio.com/

#39 — Ever wondered just what it's like working at the HHMI Janelia Research Campus? Teng-Leong Chew, Director of the Advanced Imaging Center at Janelia, joins Peter O'Toole for episode #39 of The Microscopists to let us know. We'll also discover what it was like moving from Malaysia to Wisconsin during a blizzard-enforced University of Wisconsin shutdown, and hear more about street art and unexpected violin recitals. We'll learn about the challenges that Chew has faced in his career, as well as the highlights, and hear why Chew is so passionate about equitable access to microscopy technology. Watch or Listen to all episodes of The Microscopists here: http://bit.ly/the-microscopists-yt #TheMicroscopists #microscopy #imageanalysis

As technology continues to evolve, so does our ability to explore cutting-edge scientific research. This allows for better diagnosis and treatment of medical conditions in all kinds of scenarios in the safest and most effective way possible. Scientists have been using microscopic skin imaging to diagnose ailments and treat skin tumors.  Dr. Aydogan Ozcan, Chancellor's Professor and HHMI professor, enlightens us on his fascinating research: bringing AI technology to the skin biopsy process. Trained as an electrical engineer, Dr. Ozcan became interested in biomechanical applications of light in laboratory settings.  In this episode, Dr. Ozcan discusses things like: How AI Virtual Histology is creating a faster and more cost-effective approach to biopsies. What is the efficacy of Virtual vs. Traditional testing is.  How Virtual Histology Staining may impact the medical world.  Tune in to learn all this and more in this educational podcast on a new field of scientific pioneering.  To learn more, you can look up PICTOR Labs, the start-up looking to commercialize this new tech.  This episode was brought to you by FeelGood Hemp, for 33% off your first purchase, use the code GENIUS33 at checkout! Episode also available on Apple Podcast: http://apple.co/30PvU9C

  How can analysis of DNA isolated from old, preserved organisms, bones, or tissues tell us about life today?  Dr. Beth Shapio is a professor at the University of California Santa Cruz and an HHMI [...] The post 316 – What We Can Learn from Ancient DNA first appeared on Talking Biotech Podcast.

Erich Jarvis, Professor at The Rockefeller University and investigator at HHMI, explains how studying the neural and genetic mechanisms of vocal learning in songbirds gives insights into the development of spoken language in humans. The Bioinformatics CRO is a fully distributed contract research company that serves the computational biology needs of biotechnology companies, with a focus on genomics. https://www.bioinformaticscro.com/

This episode features Daniela's interview with Ann, a Group Leader at HHMI's Janelia Research Campus who studies studies strategies for representing sensorimotor information that support efficient circuit computations and guide flexible behavior.

#25 — Harald Hess is a pioneer in the fields of high-throughput electron microscopy and super-resolution 3D microscopy, and today we'll discover more about what inspired him, his move from academia to industry and back again, and who comes off best in his tennis matches with Eric Betzig.We'll hear how Harald and Eric built the first super-resolution microscope for PALM microscopy in Harald's front room, what his mother thought of the first PALM images, and why science needs different approaches to progress.Watch or Listen to all episodes of The Microscopists here: https://themicroscopists.bitesizebio.com/

#25 – Harald Hess is a pioneer in the fields of high-throughput electron microscopy and super-resolution 3D microscopy, and today we'll discover more about what inspired him, his move from academia to industry and back again, and who comes off best in his tennis matches with Eric Betzig. We'll hear how Harald and Eric built the first super-resolution microscope for PALM microscopy in Harald's front room, what his mother thought of the first PALM images, and why science needs different approaches to progress.

The Howard Hughes Medical Institute is adding a new research focus -- 4D Cellular Physiology. On this episode of the Pathways Podcast from the American Society for Cell Biology we chat with Ron Vale, the Vice President and Executive Director of HHMI's Janelia Research Campus, and Jennifer Lippincott-Schwartz, a senior group leader also at Janelia, about this new direction and how it will impact the cell biology community. --- Send in a voice message: https://anchor.fm/ascb-pathwayspodcast/message

This week, the Lab Out Loud podcast welcomes Jared Lipworth to the show. As Executive Producer and head of Outreach and Impact at HHMI Tangled Bank Studios, Jared oversees the production of documentaries in addition to the outreach and impact campaigns built around them. Recent NSTA Conference attendees will recognize HHMI's "Night at the Movies" hosted at the annual Conference. Without a physical conference to attend, Lab Out Loud wanted to help share some of the media produced by the studio that harness the power of storytelling to inspire interest in science. Jared joins co-hosts Brian Bartel and Dale Basler to talk about the mission of Tangled Bank Studios, describes the kinds of stories they create and even shares a little advice to teachers and students making their own visual stories. Listen to the show to hear titles of shows that you can share with your students in the classroom or at home! Show notes at: https://laboutloud.com/2020/11/episode-235-hhmi-tangled-bank/

If you catch COVID-19, what are the chances you will die or get severely ill? This is an important question, and if a simple test can predict this even before you get the virus, it would create a priority list for people that should be more careful or get the vaccine earlier. If this knowledge could also offer treatment, this would be a true game-changer. It would certainly be a game-changer, and we may already be at this point according to two new studies by HHMI in Virginia, USA that offers an explanation for why COVID-19 cases can be so variable. Read the full story on eTurboNews --- Send in a voice message: https://anchor.fm/etn/message Support this podcast: https://anchor.fm/etn/support

Join us to listen to this fabulous innovator, Jason Osborne describe how he went from being a kid in South Central Pennsylvannia to scuba-diving for fossils. The story takes a palatable tale with BoneDusters Paleo Ale. While sipping beer, we move to discuss his next frontier - tackling STEM education and how he wanted to be IN the system to change it. 

That’s Dr. John Lowe, today on Behind the microscope. Dr. John Lowe, MD, is the retired Senior Director of Pathology at Genentech inc. Dr. Lowe got his MD from the University of Utah, went to residency at Washington University in St. Louis, was an HHMI investigator at the University of Michigan, chair of pathology at case western reserve University and ultimately the Senior director of pathology at Genentech before his retirement in 2018. Credits: Our thanks to Dr. Lowe for being on the podcast. Host: Bejan Saeedi Co-Host and Audio Engineer – Joe Behnke Executive Producer, Social Media Coordinator, and BTMblog Editor-in-Chief – Carey Jansen Executive Producer – Michael Sayegh Faculty Advisor – Dr. Brian Robinson Twitter: @behindthescope_ Instagram: @behindthemicroscopepod Facebook: @behindthemicroscope1 Website: behindthemicroscope.com

Welcome to Science is Fun! I hope you enjoy our first ever episode. Episodes will drop weekly, possibly less frequently due to COVID-19 and my general lack of expertise. Visit www.scienceisfuncast.com for more information. My guest this week is Richard Locksley, who is a remarkable and quite accomplished immunologist who has made seminal contributions to our understanding of T cells, innate lymphoid cells, and Tuft cells. He is an investigator with HHMI, a full Professor at UCSF, and the Director of the Sandler Asthma Basic Research Center. Rich was actually one of the more recent interviews I did for this show, but I thought that his comments on COVID-19 and infectious disease would be of interest right now. A word of warning, it has been a couple months and the science on COVID-19 is always changing, so some of what we discussed is likely out of date. I hope to have Rich and other guests on in the near future to bring you up to date. In addition to COVID-19, Rich and I discussed all sorts of equally pressing topics like video games, finance, aging, publishing, why cardiology can be boring, and a lot more. I think you're really going to like it and hope that you'll stick around for the next episode.

Greg sits down with Baylor Neuroscientist and HHMI investigator Hugo Bellen to discuss the evolution of genetic research tools over the last 30 years (1:50), the transition from a career as an engineer to veterinary medicine, to research (4:47), drosophila research and its translation potential (7:17), examining the research of neuron-glia interactions and how lipid droplets can contribute to neurodegenerative diseases (9:25), the use of mitochondrial therapeutics for neurodegenerative diseases (16:19), the undiagnosed diseases network (21:33), and future research in the Bellen lab (24:23).

Arianna and Gabrielle interview Dr. Carolyn Elya on how microbes hijack insect nervous systems to control them. Dr. Elya studies a fungus that infects fruit flies, invading their nervous system and eating them from the inside out. The fungus controls the fly nervous system to climb to a high point in the forest in order to better spread the fungus spores to infect new flies and insects. We speak to Dr. Elya about the complex relationships of the organisms and the impact of climate change on the forest ecosystems.  Dr. Elya is a postdoc at Harvard University, a was a researcher at HHMI, she received a Ph.D from the Molecular and Cell Biology department at UC Berkeley in May 2017. 

This episode is the first in a series produced in collaboration with the Society for Vascular Surgery Young Surgeons Advisory Committee (SVS YSC). This episode will focus on establishing a research lab and setting the groundwork for a productive academic career. Our guests for this episode are two members of the Young Surgeons Advisory Committee, Dr. Mohamed Zayed and Dr. Nicholas Osborne. Dr. Mohamed Zayed (zayedm@wustl.edu) has been an assistant professor of surgery at Washington University in St. Louis since 2014.  He received his medical degree and Ph.D. in pharmacology from UNC and vascular surgery residency training from Stanford.  He has received many research awards for his translational research, including the Vascular Cures Wylie Scholar, American Surgical Association Foundation Fellow and in 2016 was awarded a K08 career development grant from the NIH, National Heart Lung and Blood Institute. Dr. Nicholas Osborne (nichosbo@umich.edu, @nichosbo) has been an assistant professor of vascular surgery at the University of Michigan in Ann Arbor, Michigan since 2014.  He received his medical degree from Dartmouth and general surgery residency and vascular surgery fellowship at the University of Michigan.  He has received multiple awards for his health services research from the American Heart Association, industry and has submitted a grant through the NIH Department for Health and Human Services. Resources discussed on the show: AAS: https://www.aasurg.org/awards/ AAS Fall Courses: Grant writing course: https://www.aasurg.org/aas-fall-courses/ ASC AAS Investigator's Course: https://academicsurgicalcongress.org/sic/ Wylie Scholars Grant: https://vascularcures.org/wylie-scholar-program-2/ VESS:  https://vesurgery.org/grants-awards/ AVF: https://www.veinforum.org/avf-foundation/bsn-jobst-research-grant/ AHA: https://professional.heart.org/professional/ResearchPrograms/ApplicationInformation/ScientistPrincipalinvestigators/UCM_316962_For-Scientists.jsp SVS: https://vascular.org/career-tools-training/awards-and-scholarships Association of VA Surgeons: https://www.vasurgeons.org/research-awards.html HHMI downloadable book: Making the Right Moves: A Practical Guide to Scientific Management for Postdocs and New Faculty Melina Kibbe's book: Success in Academic Surgery: Basic Science Three main categories of research funding: Institutional microgrants Internal funding mechanisms through research centers or foundations at your institution: university, VA, etc. SVS Other professional societies' awards: AHA, ADA, VESS, etc. Foundation award K award series: career development grants for early-stage investigators R01: highest level, most coveted NIH funding

丽莎老师讲机器人之纳米级成像，人类终于看清大脑每个神经元欢迎收听丽莎老师讲机器人，想要孩子参加机器人竞赛、创意编程、创客竞赛的辅导，找丽莎老师！欢迎添加微信号：153 5359 2068，或搜索微信公众号：我最爱机器人。Science杂志最新封面报道，科学家们成功扫描了果蝇的完整大脑，达到了纳米级成像，将测绘速度提高了1000倍！有解读大脑的能力，科学家就可以追踪神经元之间的联系，从而破解大脑的奥秘。最新出版的Science杂志封面，报道了MIT和霍华德·休斯医学研究所（HHMI）科学家们的最新成果，他们成功对果蝇的完整大脑进行了成像，清晰度达到了纳米级，而且只用了不到三天时间！几十年来，神经科学家一直梦想绘制出一幅完整的大脑神经网络的精细地图，包括人脑、老鼠和果蝇的神经网络。有了这种能力，科学家就可以追踪神经元之间的联系，进而了解大脑是如何做出决定的。利用电子显微镜对果蝇大脑的神经元和突触进行全面测绘已经花费了10年的时间，数十人为此付出了努力。科学家们通过结合两种最先进的技术，膨胀显微镜(expansion microscopy)和晶格层光显微镜(lattice light-sheet microscope)，新的大脑测绘速度提高了1000倍。值得注意的是，发明了晶格层光显微术的Eric Betzig教授获得2014年诺贝尔化学奖，这次登上Science封面的论文，也有Eric Betzig的名字。论文的通讯作者MIT教授Edward S. Boyden五年前发明了膨胀显微镜，并在2018年获得了有诺贝尔风向标称号的加拿大盖尔德纳奖（Canada Gairdner International Award）。这篇论文堪称是两个顶级研究团队“珠帘合璧”的力作。纳米级观察大脑：4000万个突触一览无余电子显微镜一直是研究大脑的利器，这也是几代人努力之后探索出来的一条道路。不过，使用电子显微镜，需要花费多年的时间才能获得果蝇的大脑图像。Science最新一期的封面，介绍了一种新的大脑扫描技术，能让任何人看清果蝇大脑的4000万个突触，其中神经元相互连接。这项研究的里程碑意义在于，这张覆盖整个果蝇大脑的3D地图显示出直径只有60纳米的细节，而且只用了不到三天时间，果蝇大脑中不同的神经细胞，甚至蛋白质在空间上的相对分布都能够看到，这对基础科研意义重大。虽然其细节水平不如电子显微镜观察到的那么好，但通过计算突触，神经科学家可以判断神经连接的强度，比如那些负责记忆的神经连接。2014年获诺贝尔化学奖的Eric Betzig教授说，一天至少能扫描10个果蝇的大脑，这样的快速和高分辨率将促使科学家们提出新的问题，比如雄性和雌性果蝇的大脑有哪些差异，或者同种果蝇的大脑回路有什么差别。并且，这只是昆虫大脑复杂的网络连接的超分辨率视图，这些网络连接构成了从进食到交配的各种行为的基础，今后，扫描更高级生物的大脑，是不是可以期待一下呢？膨胀显微镜和晶格层光显微镜珠帘合璧之作MIT的Edward Boyden教授在五年前发明膨胀显微镜认为：“我们不仅仅是在逐步扫描更多的脑组织，我们是在扫描整个大脑。这就是我们如此兴奋的原因。”膨胀显微镜(ExM)的原理是将组织样本包埋在一种吸水膨胀的聚合物中，使得组织像气球一样膨胀，同时能保持内部结构的相对位置不变，然后用常规显微镜对大块脑组织进行了超高分辨率的蛋白质成像。它使用的是类似尿不湿里的聚丙烯酰胺凝胶，这种凝胶在从盐水转移到纯净水的过程中会膨胀。Betzig说：“（Boyden）他们2016年第一次来找我时，我还是充满怀疑的；我担心的是，首先，你是否可以使大脑组织这样的东西理想地膨胀，而不让它产生扭曲。然后我担心，尽管样品是透明的，它们还是会像玻璃球那样扭曲光线。”浏览果蝇大脑的高分辨率3D图像。这些彩色的球代表了大脑中神经元的一个子集上突触的密度，即那些对多巴胺有反应的神经元。这些彩色小球总共绘制了整个大脑的4000万个突触其中50万个突触的位置，红色表示突触密度最高，紫色表示突触密度最低。该联合研究团队由MIT Boyden实验室的博士后Ruixuan Gao和 Shoh Asano，以及哈佛医学院的Srigokul Upadhyayula带领，他们发现，在将脑组织膨胀4倍，体积增大到64倍后，它就几乎和水一样清澈，不会产生变形。很惊讶地发现，它的清晰度是如此完美，呈现出令人难以置信的光学均匀性。”结果，这种晶格层光显微镜能够在单个突触的水平上拍摄出一张非常详细且精确的大脑图像：分辨率达到约60纳米，仅为电子显微镜分辨率的十分之一。多色成像只需62.5小时。我们的征程是星辰大“脑”不过，Betzig预测，随着膨胀显微镜技术的改进——一些科学家已经能在每个方向将组织伸长25倍——这种结合技术在绘制大脑中所有神经连接方面可以取得几乎和电子显微镜一样好的结果。“如果你能让它在10倍或15倍的膨胀程度有效运作，科学家可能就会抛弃电子显微镜了。电子显微镜做密集神经跟踪也很好，但我们的技术要快得多，也便宜得多。我认为他们需要担心。尽管现在还不能取代电子显微镜，但在我看来，是有这种潜力的。”每一次完整的扫描，总计产生接近10TB的数据，然后由计算机组合成一个可以像视频游戏一样导航的3D图像。通过将荧光标记物附着到大脑中的蛋白质上，就有可能绘制出神经元和其他细胞的外膜、一个神经元与另一个神经元连接的突触、脑细胞的内部隔间，等等。这一研究为神经科学带来了极为重要的研究工具，帮助科学家们理解不同的神经环路如何组成，性别对大脑有怎样的影响，疾病又会怎样破坏大脑等等。研究团队不仅对果蝇的整个大脑进行了测试，还对老鼠大脑皮层上几毫米厚的一个薄片组织进行了测试，结果类似。人类的大脑有800亿个神经元，每个神经元可能有7000个突触，这或许是团队的新挑战。附Science杂志报道地址：http://science.sciencemag.org/content/363/6424/eaau8302

Professor Eva Nogales started her career in a time where barely any women were seen in science departments. In college, she skipped biology to focus on physics, relying on her high-school knowledge of the former to shape her career as a biophysicist. Now, she’s using her understanding of the microtubules in our cells for improving disease management, including slowing the uncontrollable growth of cancer. This niche understanding of our cell behaviour at the molecular level is already improving the lives of humans everywhere, and the technique used by Professor Nogales called “cryo-EM” is taking the world of structural biology by storm. She recently visited the University of Melbourne to receive the 2019 Grimwade Medal, and to deliver the oration titled: Visualising the molecular dance at the heart of human gene expression. Episode recorded: February 14, 2019.Interviewer: Steve Grimwade.Producer and editor: Chris Hatzis.Co-production: Silvi Vann-Wall and Dr Andi Horvath.Banner: Berkeley Lab.

The marriage covenant was broken through the unfaithfulness of the children of Israel, when they departed from following the Torah of Yeshua and committed spiritual adultery/idolatry in following other gods. Yet Yeshua, in his great love for His bride, makes a way for her to return: For finding fault with them, he said, Behold, the days come, saith the Lord, when I will make a new covenant with the house of Israel and with the house of Judah: Not according to the covenant that I made with their fathers in the day when I took them by the hand to lead them out of the land of Egypt; because they continued not in my covenant, and I regarded them not, saith the Lord. For this is the covenant that I will make with the house of Israel after those days, saith the Lord; I will put my laws into their mind, and write them in their hearts: and I will be to them a God, and they shall be to me a people. Hebrews 8:8-10 For the bride to be able to come into this renewed marriage covenant, she needs a heart transplant: her heart of stone must be removed and she must receive a heart of flesh. Then the Torah can be written upon her heart (Ezek 36:26-27). But he is a Jew, which is one inwardly; and circumcision is that of the heart, in the spirit, and not in the letter; whose praise is not of men, but of God. Romans 2:29 For more of Eddie Chumney teachings and to listen to beautiful Messianic worship music, visit us at our internet streaming radio station, http://www.hebrootsradio.com/. Please visit our home page at: http://hebroots.org/

The story of the bible largely surrounds Yeshua’s desire to have a bride that He can live and dwell with forever. To have this bride, He is going to enter into marriage covenant relationship with her. She will ultimately break the marriage covenant with him. However, his love for his bride is so great that He will lay down His life as a kinsman redeemer in order to redeem His bride. He wants to see restoration of this marriage relationship. In doing so, Yeshua established a new covenant so that His Torah could be written upon her heart through the power and inspiration of the Holy Spirit. In order for the relationship to be restored, she needs to have a change of heart. When she repents of her sins, she must accept Yeshua as her Messiah and make Him LORD of her life. As she lives a resurrected life in Him she can produce the fruit of the Spirit. In doing so, she will be able to live forever with Him in the New Jerusalem as His bride. For more of Eddie Chumney teachings and to listen to beautiful Messianic worship music, visit us at our internet streaming radio station, http://www.hebrootsradio.com/. Please visit our home page at: http://hebroots.org/

In the garden of Eden, there was a marriage that took place between Adam and Eve. This marriage was a prophetic picture of the marriage between Yeshua and his bride. We can compare Genesis 2:21-22 what Paul describes to us in Ephesians 5:22-27. In Ephesians 5:30-31, Paul is speaking to us at the “sod” level when he states: For this cause shall a man leave his father and mother, and shall be joined unto his wife, and they two shall be one flesh. This is a great mystery: but I speak concerning Christ and the church. In the marriage between Adam and Eve, sin enters the picture when they eat from the tree of the knowledge of good and evil and they are banished from the garden: So he drove out the man; and he placed at the east of the garden of Eden Cherubims, and a flaming sword which turned every way, to keep the way of the tree of life. Genesis 3:24 In Hebrew, “drove out” is “garish” and it means: to drive out, expel, cast out, drive away, to divorce. This is a prophesy. Even as Adam and Eve are “divorced” from the LORD; they are banished from the garden. Similarly, the bride of Messiah sins, she falls into idolatry and golden calf mixed worship system and she too, will be banished from Israel and is exiled to the nations (both Northern and Southern kingdom). Yet, Yeshua is going to make a way of return for her. Listen in and find out more! For more of Eddie Chumney teachings and to listen to beautiful Messianic worship music, visit us at our internet streaming radio station, http://www.hebrootsradio.com/. Please visit our home page at: http://hebroots.org/

In the last two sessions, we looked at the purpose of creation and we looked at the deeper meaning of the marriage between Adam and Eve. In this session, we are going to see that Abraham represents the calling that Yeshua has on His bride to leave the world and to follow the voice and the leading of Yeshua, her bridegroom. Abraham was “called out” as part of the bride of Yeshua in Genesis 12:1: “Now the LORD had said unto Abram, Get you out of thy country, and from your kindred, and from your father's house, unto a land that I will show thee…” The bride is asked to leave the place of the “known”, the “familiar” and the “comfortable” and go to the “unknown”, the “unfamiliar” and the “uncomfortable”. Abraham gives us an example of that journey. In order for her to step out of her comfort zone, she is going to have to TRUST the God of Israel. In order to encourage her, she is given a promise. The promise given to Abraham is this: And I will make of you a great nation, and I will bless you, and make your name great; and you shall be a blessing: And I will bless them that bless you, and curse him that curses you: and in you shall all families of the earth be blessed. Genesis 12:2-3 Abraham says “yes” to the invitation. We then follow his “journey” as it is our own “journey of the bride”. For more of Eddie Chumney teachings and to listen to beautiful Messianic worship music, visit us at our internet streaming radio station, http://www.hebrootsradio.com/. Please visit our home page at: http://hebroots.org/

In the restoration of the relationship between Yeshua and His bride, there is going to have to be a separation of the bride from the other gods that she went after. She is going to have to repent, leave Egypt/Babylon. When we depart from Torah, we will come under oppression and bondage. Yeshua has to redeem His bride, who has gone into bondage: Wherefore say unto the children of Israel, I am the LORD, and I will bring you out from under the burdens of the Egyptians, and I will rid you out of their bondage, and I will redeem you with a stretched out arm, and with great judgments. And I will take you to me for a people, and I will be to you a God: and ye shall know that I am the LORD your God, which bring you out from under the burdens of the Egyptians. Exodus 6:6-7 The exodus story is a picture of personal salvation. When the children of Israel are instructed to take a lamb, slaughter it, and then place the blood of the lamb on the doorposts, this is a picture of each one of us: we are to repent of our sin, and then place the blood of Yeshua our Messiah upon the doorposts of our heart. For more of Eddie Chumney teachings and to listen to beautiful Messianic worship music, visit us at our internet streaming radio station, http://www.hebrootsradio.com/. Please visit our home page at: http://hebroots.org/

There was a marriage that took place at Mt Sinai. In this session, we learn about the details of this marriage betrothal that took place at Mt Sinai. Yeshua was the bridegroom, and he gave his Torah (the Ketubah) to his bride, the house of Jacob. The Torah is part of the marriage covenant proposal. She said “yes” to the marriage proposal: And Moses came and called for the elders of the people, and laid before their faces all these words which the LORD commanded him. And all the people answered together, and said, All that the LORD hath spoken we will do. And Moses returned the words of the people unto the LORD. Exodus 19:7-8 The Torah is the inheritance of the bride (Deut 33:4). The land of Israel is also an inheritance of the bride (Deut 31:7). The bride was unfaithful to Yeshua, her bridegroom and her marital unfaithfulness was a departing from keeping and following the Torah. This marital unfaithfulness resulted in her being put outside of His house, or exile from Israel. I said, I would scatter them into corners, I would make the remembrance of them to cease from among men. Deut 32:26 But if ye will not hearken unto me, and will not do all these commandments; And I will scatter you among the heathen, and will draw out a sword after you: and your land shall be desolate, and your cities waste. Leviticus 26: 14, 33 However, his love for his bride is so great that He will lay down His life as a kinsman redeemer in order to redeem His bride. He wants to see restoration of this marriage relationship. For more of Eddie Chumney teachings and to listen to beautiful Messianic worship music, visit us at our internet streaming radio station, http://www.hebrootsradio.com/. Please visit our home page at: http://hebroots.org/

Today, our guest is Rui Costa,an HHMI investigator at the Champalimaud Center for the Unknown in Portugal. Well be speaking with him about using transgenics to study complex disease, the neural mechanisms underlying habit learning (like piano playing), and keeping cows as pets.

Gail Mandel talks about her long, and winding journey into neuroscience, what makes a neuron a neuron, how astrocytes contribute to neurological disorder, and more! Dr. Mandel is a Senior Scientist at the Vollum Institute and a Professor in the Department of Biochemistry and Molecular Biology at the Oregon Health and Science University, as well as an HHMI investigator.

Thursday, October 20, 2011 Stephen Lisberger (Professor, HHMI & UCSF) talks with Charles Wilson about solving the problem of how circuits generate behavior using low dimensional model systems, and why it is important to study variability in the nervous system. Duration: 30 minutes acknowledgement: JM Tepper for original music.