Podcasts about episode fifteen

This is our first podcast recorded in our ‘real studio’ since the pandemic started! We followed COVID-19 state guidelines but it felt great to be back here with Dan Rhiger and both Kyle and Candace! We decided to go back to our roots and dig into menopause. We have touched on many aspects of perimenopause and menopause in previous episodes but this episode brings it all together. In our previous episode, with Dr. David Zava of ZRT Laboratory, he spoke about the hormonal changes that can start as early as age 35, leading to perimenopause. In this episode, we discuss “what to expect when you are expecting menopause.” Listen on Apple Podcasts Listen on Spotify Show Notes for Episode Fifteen

Hello again everyone, here is Episode Fifteen, the second part of my conversation with Justin Elden on this Sunday double-fun day.  The main thrust of our conversation is Justin's work in Guatemala with the Highlands and Islands Conservatory, which is centered around the pictured Guatemalan pit viper, Bothriechis aurifer, but of course includes other herps and more importantly, their habitats.  And of course, we wandered off topic, but in ways you'll appreciate! Justin and his associates put in a lot of time and effort with this conservation project, and that includes getting the local people involved, and in some cases employed. So what can YOU do to help?  Pretty simple - buy a tshirt or other merch at the links below and I will say thanks in advance! The Highlands and Islands Conservatory also has a FaceBook page that you can follow.  I'm also including a link to the associated Ranchitos del Quetzal Natural Reserve, where birders come to see the Resplendant Quetzal, and which I myself hope to visit when travel is again open and safe.  I might even look for a quetzal. Here's the link to Highlands and Islands merchandise, which feature Bothriechis aurifer, and here is the link to the original Mayan t-shirt design, which is pretty cool as well. One more bit of Herp Love:  here's a link to the FaceBook page of Andres Novales, who is involved with the conservation projects with his buddy Justin.  Andres shares his great photos of Guatemalan wildlife on his page.  Check it out! And on a final note: we make fun of Marlin Perkins a bit, but the dude was pretty bad-ass in all actuality.... Once again, thanks Justin for coming on the show!  And thanks for listening, everyone!  The show email is somuchpingle@gmail.com, and there’s also a So Much Pingle group on Facebook, for discussion, comments, feedback, suggestions, herp confessions, tips for herping better, etc. Stay tuned for more episodes! And don’t forget to herp better! -Mike

Episode Fifteen features Carrie Mae Weems (b. 1953 Portland, OR; lives and works in Syracuse, NY). She is widely renowned as one of the most influential contemporary American artists living today. Over the course of nearly four decades, Weems has developed a complex body of work employing text, fabric, audio, digital images, installation, and video, but she is most celebrated as a photographer. Activism is central to Weems’ practice, which investigates race, family relationships, cultural identity, sexism, class, political systems, and the consequences of power. Over the last 30 years of her prolific career, Weems has been consistently ahead of her time and an ongoing presence in contemporary culture. Her work is organized into cohesive bodies that function like chapters in a perpetually unfolding narrative, demonstrating her gift as a storyteller. The Kitchen Table Series (1990), for instance, is one of Weems’ most seminal works, and widely considered one of the most important bodies of contemporary photography. The series, for which Weems herself posed as the main subject, is set at a woman’s kitchen table—a domestic stage—revealing intimate moments of her life as the story unfolds. The protagonist, though in many ways seemingly commonplace, is a multifaceted woman encompassing a variety of roles such as lover, parent, friend, and breadwinner. Through her work, Weems tackles a number of complex contemporary issues, demanding reconsideration of predominant narratives throughout our history. This is an intriguing and mentally stimulating conversation. Enjoy. http://carriemaeweems.net/ https://jackshainman.com/artists/carrie_mae_weems https://www.macfound.org/fellows/905/ https://news.syr.edu/blog/2020/01/15/internationally-renowned-artist-carrie-mae-weems-named-university-artist-in-residence-at-syracuse-university/ https://www.christies.com/features/Carrie-Mae-Weems-Change-Requires-2020-Vision-10437-1.aspx https://en.wikipedia.org/wiki/Mary_Lovelace_O'Neal https://en.wikipedia.org/wiki/Barbara_Chase-Riboud https://en.wikipedia.org/wiki/Hung_Liu

Episode Fifteen of the Punk Rock Classrooms Podcast! "Leading Isn't Selling Out!" Being called a sellout was the ultimate jab at bands that ended up getting big or bigger than the punk rock scene. Sometimes educators view leadership or administrators as the dark side. Mike and Josh think we need punk rock leaders in education and that doesn't mean you have to be an administrator or that you have to "sell out." So bring your passion, unity, and DIY to the leadership roles you take on because we need punks all over education. Twitter twitter.com/punkclassrooms twitter.com/educhefearnshaw twitter.com/JoshRBuckley Intro music - "Please Play This Song on the Radio" by NOFX Outro music - "Johnny Quest Thinks We're Sellouts" by Less Than Jake Check out our PRC Playlist here for all of the rad tunes we use: bit.ly/PRCPlaylist

Episode Fifteen sees us take an extra-deep dive into the world of the Xenomorphs! Chest-bursting, egg-laying, acid-for-blood space bugs, could they be closer than you think? As in, could they have been inside you all this time? Is this extended space opera just a microscopic power play being fought between red blood cells and hostile bacteria? Note: Due to the current circumstances, we could not consult an actual doctor to verify any of the claims we are making.

We have a jam packed episode for your ears this week! We continue with our viewing of Season One of the Clone Wars, as we cover episode 17-20. There is also a laxative driven poop-shoot of news as we talk about Project Luminous, some Mandalorian notes, a world premiere of a lost music track and much more! Turn up your headphones, dial back your sensibilities, and join the wretched hive of scum and villainy as we take the low road to resistance on Episode Fifteen of Force Insensitive!Send Email/Voicemail: mailto:forceinsensitive@gmail.comStart your own podcast: https://www.buzzsprout.com/?referrer_id=386Use our Amazon link: http://amzn.to/2CTdZzKFB Group: https://www.facebook.com/groups/ForceInsensitive/Twitter: http://twitter.com/ForceNSensitiveFacebook: http://facebook.com/ForceInsensitiveInstagram: http://instagram.com/ForceInsensitive

We have reached Episode Fifteen of Fly On The Call! This week I am speaking to Matt Brasch about Cold Climb It and their new EP In Decline. Apart from that, you may know Matt from his main project, The Wonder Years. In this conversation we discuss the origins of Cold Climb It, which started as a solo project, and the mindset behind the band. We also hit on each song on In Decline, the process of self-recording, and much more. Links: Cold Climb It - Bandcamp | Instagram | Facebook | Purchase physical The Wonder Years - Website The Grey Estates - Website | Twitter Fly On The Call - Twitter | Instagram | flyonthecallpod@gmail.com Promoted by The Alternative - Website | Twitter | Patreon | Mixcloud Artwork by Mikaela Jane Palermo - Website | Twitter | Instagram Theme song by Kailynn West of Tiny Stills - Website | Twitter | Bandcamp

This week on Not Like The Other Girls we're talking the wonders of living abroad! If the current housing crisis in Ireland doesn't make you want to leave then our hot takes on confusing tax systems, governments trying to seize our stuff, and foreign men not finding us attractive will definitely have you sold! We're joined this week by the finest woman in Waterford, Shannon O'Reilly to really hammer home the joys of culture shock and homesickness. Available on all platforms now![Image description: a plastic toy man in a white coat holding a briefcase stands on a map with an arm raised as if to flag a taxi. The text reads Not Like The Other Girls, Episode Fifteen, Living Abroad]#NLTOG --- Send in a voice message: https://anchor.fm/the-cop-on/message

How do you know what to do with your life? We find out one version in Episode 15 of the Planetary Potential! The Planetary Potential is hosted by Andrew P. Rowan and is recorded on location. This is Episode Fifteen of Season One which features 20 episodes with a common theme of Peru. For a transcript of this episode, head over to https://andrewprowan.com/episode-15-of-the-planetary-potential-with-carolina-botto. For exclusive bonus content, including extended versions of this and other interviews, head over to https://www.patreon.com/planetarypotential --- Send in a voice message: https://anchor.fm/planetary-potential/message

We have guest lecturer and playwright Carol Wolf with us, teaching the most important elements in creating a play: Creating tension, 3D characters, and writing for a confined visual space. … Continue...Episode Fifteen – The Play’s the Thing

Welcome to Episode Fifteen of Strange Pleasures Radio Lab. Your daily audio story podcast available through iTunes, Spotify and YouTube.Each day I will narrate a well known story in it's entirety. As a writer I will also include some narration of my own books that can be purchased through the Amazon Kindle Store, or through the Amazon Prime Kindle Unlimited subscription program.Today I will be narrating The Cremation Of Sam McGee by Robert W. ServiceYOUTUBE: https://www.youtube.com/channel/UC8MoqBN8-vdAsaoYBZX32OA?viewas=subscriber?subconfirmation=1HOME WEBSITE https://strange-pleasures-radiolab.pinecast.co/SPOTIFY https://open.spotify.com/show/6x2VOcohjOKeJ8ZIJpvi8rAMAZON AUTHOR PAGE https://www.amazon.co.uk/Robert-Knight/e/B07WH3QCML/ref=dpbylinecontpopebooks_1ITUNES https://podcasts.apple.com/gb/podcast/strange-pleasures-radiolab/id1476208251STRANGE PLEASURES VIDEO LAB: https://youtu.be/9gwuSXroVvkSupport Strange Pleasures Radiolab by donating to the tip jar: https://tips.pinecast.com/jar/strange-pleasures-radiolabFind out more at https://strange-pleasures-radiolab.pinecast.coThis podcast is powered by Pinecast.

We went to the dentist today so there's no description because our teeth hurt D: You can still check us out on Twitter @MyHeroNotebook

Episode Fifteen - The Ultimate Warrior World ChampionJoin Better Call Creative as they begin a story arc examining one of the most colourful, and controversial characters in the history of wrestling, The Ultimate Warrior.Starting at Episode Fifteen, the boys review The Ultimate Warriors Title run, from taking the crown from the biggest name in Wrestling, to dropping it to well....not the biggest name! What mistakes were made to make this the one and only time Ultimate Warrior held the top belt, and what could the WWF have done differently. Joins the Better Call Creative boys as they examine every questionable knuckle lock, every dangerous back body drop, and every snarling, snorty promo. Would you drink the sweat from the devil's armpit.....no....well you had Better Call Creative then!

Episode Fifteen of the kind of wrestling adjacent podcast by the high flying death defying luchador Lucha DS Officially sponsored by Masked Republic Follow Lucha DS on social media Facebook https://en-gb.facebook.com/luchaDS/ Twitter https://twitter.com/luchads?lang=en Instagram https://www.instagram.com/luchads/?hl=en YouTube https://www.youtube.com/channel/UC5FVmhw5098RETSkKmcOCsg

Welcome to Episode Fifteen of the When In Yorkshire Podcast. My guest this week is Tobi Duncan of UK Punk Rock band Trash Boat. It was a pleasure to chat to Tobi ahead of Trash Boats' show supporting Yorkshire favourites While She Sleeps at the O2 Academy in Leeds. In what feels like a relatively short time -as an outsider, Trash Boat have released two albums, signed to Hopeless Records and covered a substantial amount of the globe. I chat to Tobi about his introduction to music, influences and plans for the future. Shortly after recording this Trash Boat have announced a headline tour so jump on to their website / social media to find a suitable date and purchase tickets - their live show is fantastic and well worth your time /money.   https://www.trashboat.co.uk/   Once again I have given a shout out to Audio Architect Apparel - check out their webstore and use WHENINYORKSHIRE10 to get 10% off https://www.audioarchitect.co/

In this week’s episode of COSMOS AND THE CITY: THE SEX AND THE CITY PODCAST, your host Megan McIver will sit down with the stupendous Brie Eley. Together these two will discuss Season Three, Episode Fifteen of SEX AND THE CITY entitled: “Hot Child in the City”This week Megan & Brie will be talking through: Samantha’s Demanding Bat-Mitzvah client, Charlotte’s trip to the sex therapist, Miranda’s newest dental work, and Carrie’s latest fling still living at home.Plus we’ll have all your favorite segments: Hottie of the Week, Pun of the Week, Good Big Bad Big, Who Wore What Why?, and You’re Such a _________.Will Samantha keep her 13 year old client happy? With Charlotte figure out what gets Tre going? Will Miranda’s Metal Mouth derail her love life? Will Carrie have another Failure to Launch on her hands? Through all the craziness Megan & Brie will share their thoughts on ABSO-FUCKING-LUTELY EVERYTHING.EPISODE SYNOPSIS: “Samantha is hired as the publicist for Jenny Bryer's A-list Bat Mitzvah. Jenny and her galpals are so New York, and so over-sexed that Samantha starts to wonder whether there's any difference between Jenny at 13 and Samantha at 34. Miranda's new braces also have her feeling like a teenager these days. After a new date fears he'll get caught in her jaws, she dumps the braces. Charlotte scours the internet in a desperate search for a solution to Trey's sexual problem. When she suggests they discuss options, Trey gets angry and asks Charlotte to accept that he's just not that sexual of a guy. Finding this unacceptable, Charlotte demands they see a sex therapist whose first suggestion is they name their private parts, Rebecca and Schooner respectively. Meanwhile, Carrie meets her latest man, Wade, at a comic store. She falls in love with his amazing Manhattan apartment, until Wade's mom comes home. Carrie plays along with her mama's boy, accepting fresh-baked cookies and all, until Wade's mom busts Carrie and Wade for smoking pot. But Carrie isn't the only one busted. Charlotte wakes up in the middle of the night to find Trey masturbating in the bathroom to Juggs magazine.”Thanks for listening! If you wanna support our show by shopping on Amazon, use our link.Our Host: Megan McIver• Twitter• Instagram• FacebookOur Guest: Brie Eley• Instagram• TwitterWhat We Watched:• Sex and the City Season Three Episode FifteenCosmos And The City Social Media• Instagram • Facebook• Twitter• WebsiteMusic by Jon Fredette • Website See acast.com/privacy for privacy and opt-out information.

Episode Fifteen

Episode Fifteen of Ms. Demeanor & Ms. Conduct. A bi-weekly, light hearted look at all things mysterious in Canada. Tales of murder, mystery, conspiracy, cults & much more. Miss & Misters, it’s The Halloween Spooktacular! This week Jena & Kennedy bring you a ‘monster mash’ of tales with creepy pastas, haunted houses, ghost stories and more! Let us chill you. Let us thrill you. Let us not trick you, but treat you. Happy Halloween to all!

Episode Fifteen. From Rodeax, the company that bought you Tales from Wytch Haven and In The Frame: The Film Review Podcast, now brings you; The CLASSIFIED Transmissions. A short 24 episode series. The Cronos Star liner has become over run with a deadly being known as the krill. Follow one mechanic's mission as he tried to save himself and anyone else that hasn't been met with the slaughter the krill bring with them. Created by Dan Lee & Rodeo Whiter Voiced by Dan Lee & Rodeo Whiter Introducing Phill Boobyer Produced by Rodeax Ltd.

In this week’s episode of COSMOS AND THE CITY: THE SEX AND THE CITY PODCAST, your host Megan McIver will sit down with the terrific Beth Rowe. Together these two will discuss Season Two, Episode Fifteen of SEX AND THE CITY entitled: “Shortcomings”This week Megan & Beth will be sorting through: Samantha sleeping with Charlotte’s brother, Miranda dating a single father, Charlotte dealing with the fact that her brother slept with Samantha and Carrie dating a man with the perfect family who happens to cum quickly in bed.Plus we’ll have all your favorite segments: Hottie of the Week, Pun of the Week, Who Wore What Why?, You’re Such a _________ and our BRAND NEW SEGMENT “I Couldn’t Help But Wonder....”Will Samantha and Charlotte’s brother become an item? Will become an insta-mother? Will Charlotte get the image of her brother and Samantha out of her head? Will Carrie stay together for her mans family? Through all the madness Megan and Beth will share their thoughts on ABSO-FUCKING-LUTELY EVERYTHING.EPISODE SYNOPSIS: “Miranda considered Sunday a nightmare because children swarm everywhere, there is even a family hour at her gym, but it did allow her to meet hunky Simon Cobb, indulgent divorced father of rascal Simon, who loves to push the elevators’ buttons, and his; when Simon surprises her naked in the lo after a hot night, that signs her marching-orders. Carrie met fiction writer Vaughn Wysel at a lunch; he presents her to mother Wallis, her partner Duncan, a teacher, and sisters Franny and Zoe, who all insist she stays for a seafood feast; six hours later he can finally jump her bones, yet his sperm beats him to the post. She keeps dating and doing him for his whole family, mainly the fascinating mother, an Oscar-nominated documentary maker, despite his recurring precipitous wetness, but precisely her liberating education without sexual taboos proves unsurmountable. Charlotte receives her studly brother Wesley, about to be divorced from Lesley; he tickles Samantha's fancy at first sight. Charlotte explodes finding Sam in her guest-room wearing only his T-shirt, but when Wesley explains he needed the sex after two sexually frustrated years with his frigid wife, Charlotte goes make up.”Thanks for listening! If you wanna support our show by shopping on Amazon, use our link.Our Host: Megan McIver• Twitter• Instagram• FacebookOur Guest: Beth Rowe• Instagram• Twitter• Persisters: Live Show & Podcast• WebsiteWhat We Watched:• Sex and the City Season Two Episode FifteenCosmos And The City Social Media• Instagram •... See acast.com/privacy for privacy and opt-out information.

On the programme this week is the architect Tatiana von Preussen. Tatiana originally studied architecture at Cambridge University in the UK.  After a year out working for the architecture firm Stanton Williams, she moved to New York to attend Columbia University’s Graduate School of Architecture to complete her Masters. After graduating in 2007 she stayed … Continue reading "Tatiana von Preussen – Episode Fifteen"

Episode Twenty-Seven features Episode Fifteen guests back again, Terry the Tickler and A Bunch of Baby Ducks, with host Captain Death(since episode 15), telling lots of stories and talking about cum for a little bit. Oh. We also do a MadLib. It's terrible. Your Last Breath(7:02)The Pill(11:19)The Squirming Man(20:06)Birthmarks(27:15)We Danced(29:29)Who or What are the Shadow People?(34:30)5 Minutes(42:00)Trollpasta Madlib: The Killer(43:57)The Legend of FingerGuy(49:17)Mailbox(52:20)CHECK THE YOUTUBE for EPs! SUBSCRIBE @https://www.youtube.com/channel/UCxoqIN-fkfdlmGEjWujypxwFeaturing wonderful ambient music from our fam in Sweden: CryoChamber, givin' us all the ooky-spooky tunage. Follow: @cryo-chamberThank you!"Are You Afraid of the Dark Theme Song," "Spooky Skeletons REMIX," and "You Reposted in the Wrong Neighborhood" are not my songs. Credit and All rights are reserved by the owners

Episode Fifteen features guest Terry the Tickler back again with new-timer A Bunch of Baby Ducks, and host Captain Death, where they seem to screech and howl constantly between 2-Sentence Horror Stories and some Troll Pasta. Second and probably less understandable 2 guest episode test. ENJOY.2-Sentence Horror Stories(5:54)The Deep(25:44)Cats(27:05)Homeless Man(28:25)Just an Ordinary Couple(30:20)666 Grant Thomas(31:20)Zach and Meghan(33:33)The Wrong House(35:02)Friday(35:39)Who was Skeleton?(38:13)Deja Vu(44:37)Scary Girl(45:20)CHECK THE YOUTUBE for EPs! SUBSCRIBE @https://www.youtube.com/channel/UCxoqIN-fkfdlmGEjWujypxwFeaturing wonderful ambient music from our fam in Sweden: CryoChamber, givin' us all the ooky-spooky tunage. Follow: @cryo-chamberThank you!"Are You Afraid of the Dark Theme Song," "Spooky Skeletons REMIX," and "You Reposted in the Wrong Neighborhood" are not my songs. Credit and All rights are reserved by the owners

It’s our Quinceañera….EPISODE FIFTEEN! This week, B&K are extremely annoyed with each other, Bonnie recaps her shameless behavior at ACL, Nick & Jim Andrews battle it out in the Current Events Couple’s Challenge, Bon explains Dutch Rudders to Kevin, Salamanderous Scoundrels, & Birthdays!

Womankind’s guest in Episode Fifteen, Jessica Decker, gets real about motherhood and what it really mean to be a “stay-at-home mom”. We discuss social media, society’s misconceptions, and changing relationship dynamics—all in relation to motherhood. We also play a game in which Jessica responds to comments that people make to new moms!

It was a crisp, cold winter morning in February in Great Falls Montana when 10-year-old Zachary Ramsay stepped out of his apartment building and was on his daily morning walk to Whittier Elementary.To Zach and his family, this was routine, and no one had any reason to fear for his safety, but on that 6th Day of February, evil would make its presence known. Zach would never make it to his school and he would never return home. You Zachary would disappear completely with speculation that he was abducted, murdered, cannibalized and portions of his organs and flesh sold to the community.This is Unsolved Mysteries of the World Season One, Episode Fifteen, The Disappearance of Zachary Ramsay. See acast.com/privacy for privacy and opt-out information.

Episode Fifteen of IdeaPod. Everyone knows that when your mom thinks something is cool…it automatically becomes uncool. So, let’s see how Old Spice takes a spin on this as they create a crazy ad targeting teenage boys…and their moms? Read More The post #15 Boys to Men to Moms appeared first on Bandwidth Marketing.

This week’s guest is Tyler Gildin, stand-up comedian and executive producer at Elite Daily. Here’s some of the stuff we talked about: when did he first realize he was funny? (2:10), what he was like, comedically, growing up and through school (3:05), why going to summer camp as a kid helped him get experience and comfort…Continue reading ➞ Episode Fifteen – Tyler Gildin, Elite Daily

Episode Fifteen of the Hairy London Podcast

Episode Fifteen of Red Moon Radio features Grand Rapids, Michigan’s LLOYD BRAUN, speaking about cassettes and vinyl, Spotify playlists, the band’s Seinfeld connection, and so many Grand Rapids’ bands! LLOYD BRAUN – New Age Hooey – The Point Interview with Eric Grinwis and Jacob Bullard of LLOYD BRAUN LLOYD BRAUN – Too Real – Too Real LLOYD BRAUN – New Age Hooey – Ode to Bug W. GUEST DJ SET FROM LLOYD BRAUN – Teenage Fanclub – Bandwagonesque – Alcoholiday GUEST DJ SET FROM LLOYD BRAUN – Yuck – Yuck – Georgia GUEST DJ SET FROM LLOYD BRAUN – Hop Along – Painted Shut – Texas Funeral GUEST DJ SET FROM LLOYD BRAUN – Dogs on Acid – Dogs on Acid – Keep in Touch GUEST DJ SET FROM LLOYD BRAUN – Weezer – B-sides and Rarities - Suzanne LLOYD BRAUN – Unreleased Demo Track – The New Me & You LLOYD BRAUN – Too Real – In the Galaxy LLOYD BRAUN – New Age Hooey – Big Red Check out LLOYD BRAUN on Bandcamp at lloydbraun.bandcamp.com and on Facebook at facebook.com/LloydBraunMusic, and look for their music on Spotify! If you enjoyed the show, please follow Red Moon Radio on Twitter, Facebook, and subscribe to the show through Stitcher, iTunes, or here, on PodOmatic! And don’t forget, you can also now find us on 50thirdand3rd.com! Photo credit: Casey McClurken

Join comedians Rachel Fairburn and Kiri Pritchard - McLean as they explore a shared passion, serial killers. Each episode the pair will talk all things murder and macabre and have a right laugh doing it. Episode Fifteen looks at Ed Kemper, The Co-Ed Killer. He's a big lad with a high IQ and from what Rachel and Kiri hear, he writes back to you. Let's hope he doesn't listen to podcasts for their sake. Also, there's an off the cuff joke in there that probably should have been cut but it's in there now. Enjoy!

Episode Fifteen. Lift your legs and open them for adventure! Will avoids our murder list by returning to discuss this very nautical themed episode. Al makes friends with a lithotome... (Please take your hand off my shoulder.) The mysterious Mister W makes a meal of E.B.... (Remove your hand from my forearm.) A pissed-off Alma directs her ire towards Sofia's tutor... (Do not touch me again.) But will the camp rise up against the ne'er-do-well Jumbo and make him pay for his slothful ways? ... Also, John tells us about the tragic demise of Miss Kitty LeRoy in the opening chapter of a Readers Theatre two-parter. (Do not look at my face.) | Send feedback to hooplecast@gmail.com. Find our recording schedule, show notes, discussion threads, and more at hooplecast.com. | Recorded August 30, 2015. Released September 4, 2015. [Warning: Explicit Language.]

In this week's episode we discuss: - NYT Obituary for Dr. Julian Bond. RIP: http://www.nytimes.com/2015/08/17/us/julian-bond-former-naacp-chairman-and-civil-rights-leader-dies-at-75.html?_r=1 - An interview between Dolen Perkins-Valdez and Lauren Francis- Sharma about the power of the American story: http://www.salon.com/2015/07/24/the_power_of_the_american_story_i_want_to_read_something_that_reaches_inside_me_and_rips_me_up_and_puts_me_back_together/ - The Iowa Barber offering haircuts for the price of a book being read to him: http://m.globegazette.com/ap/state/article_c208d548-72ab-51c4-b54c-c13e90dad31f.html?mobile_touch=true - And wrap up with a throwback to Episode Fifteen with books on books on books part deux!

Shocking twists and turns swift by Nell and his friends, as the people they've put their trust in suddenly attempts to kill them. As they slowly learn the truth, Vayne and his allies escape to fly over to Xiaolin City in hopes of an attack of despair.

[intro music]   Host – Dan Keller  Hello, and welcome to Episode Fifteen of Multiple Sclerosis Discovery, the podcast of the MS Discovery Forum. I’m your host, Dan Keller.   This week’s podcast features an interview with Professor Ludwig Kappos about a recent head-to-head clinical trial of the experimental drug, daclizumab, versus interferon. But to begin, here's a brief summary of some of the latest developments on the MS Discovery Forum at msdiscovery.org.   We recently released a news synthesis by science writer, Carol Morton, that goes along with this podcast. The article is all about daclizumab, its history, and the recent results of the phase 3 clinical trial. The results of the clinical trial show that the drug is better than interferon at reducing disease activity in patients with relapsing-remitting multiple sclerosis. Surprisingly, recent research suggests that daclizumab works by natural killer cells to target autologous T cells. It may also work in two more unusual ways—go to our website to read the whole story.   Antibodies to myelin oligodendrocyte glycoprotein—also known as MOG—may play a role in a subset of patients with neuromyelitis optica spectrum disorders according to several labs in Europe and Asia. At the ACTRIMS-ECTRIMS meeting in September, several of these labs presented data that showed patients who test positive for the MOG antibody had a very different clinical phenotype from the majority of NMOSD patients who have an antibody to a different protein, called aquaporin-4. The findings could mean that anti-MOG-positive patients represent a distinct disease subgroup.   Recently we’ve added quite a few items to our meetings and events page. From webinars to large annual meetings, there’s an event for everyone’s schedule in the remaining months of 2014 and well into the summer of 2015. Go to msdiscovery.org and click on the “professional resources” tab. From there, click on “meetings and events” to view all the items. And if you have a meeting you’d like us to list, please send the information to editor at msdiscovery.org. Hardly any meeting is too small. We’re even willing to list local departmental seminars.   [transition music]   Now to the interview. Professor Ludwig Kappos is the chair of neurology at the Neuroscience Network at the University of Basel in Switzerland. He met with me at the 2014 international ACTRIMS-ECTRIMS meeting in Boston to discuss the findings of the phase 3 DECIDE trial of daclizumab versus interferon. Daclizumab is a monoclonal antibody against the alpha subunit of the interleukin-2 receptor.    Interviewer – Dan Keller Welcome, Professor Kappos. Let's talk about the study you're presenting here at ACTRIMS on daclizumab. What was the aim of the study?   Interviewee – Ludwig Kappos The aim of the study was to position this compound in relation to an established treatment with interferon and to see if these positive effects that had been observed in studies where it was used as an add-on to interferon or as compared to placebo if these also stand in comparison with interferon.    MSDF How did you go about it: methods, interventions, patient population?   Dr. Kappos It was double-dummy controlled, parallel group study lasting a minimum of two years per patient in a population of active relapsing-remitting multiple sclerosis. And patients were randomized equally either to daclizumab once per month subcutaneous or to interferon beta-1a once a week intramuscularly and received dummy injections in order to keep the blind.    MSDF How did you decide on a once monthly dose for the daclizumab?   Dr. Kappos That was the result of previous studies where it had been shown that this once monthly dose is sufficient to achieve the effects that we expected to see.    MSDF Because it's a monoclonal it has a long pharmacokinetic profile. Is that right?   Dr. Kappos This is something that is shared also with other monoclonals. The advantage here is that you can apply it subcutaneously; they don't intravenous infusions like, for example, with natalizumab.   MSDF What did you find?   Dr. Kappos The primary outcome was reduction in relapse rate, and as compared to interferon beta-1a, it do add to a reduction that was close to 50%.    MSDF What about a proportion of patients experiencing relapse?   Dr. Kappos Again, there was a significant reduction, and the curves separated already after the first half year. So the effect was relatively early.    MSDF And what about some of the imaging? What did you find on MRI and how about patient disability?   Dr. Kappos Yeah again, as compared to interferon, it had a much more pronounced reduction of inflammatory activity, as depicted by T2 lesions or gadolinium-enhancing lesions in the scans during the study. And it also had an affect on T1 hypointense lesions that were reduced as compared to interferon. And interestingly enough, although it had a more pronounced antiinflammatory activity also in early and over the whole duration of the study, positive affect on brain volume loss.    MSDF It appears that in both groups about 30% of the people discontinued. Were there any differences in reasons or couldn't you discern that?   Dr. Kappos Overall there was a similar incidence of adverse events, but there were somewhat more serious adverse events and adverse events as a reason for discontinuation. This was mainly related to cutaneous side effects; so rashes itching that in some cases needed discontinuation, in others could be treated sufficiently with ongoing medication or resume medication with steroids.   MSDF This was not just local infusion reactions but more generalized skin reaction?   Dr. Kappos They were independent of the injection site; so they did not occur at the site of injection but in other parts of the body.   MSDF Is there an explanation in terms of IL-2 for that, or was it just sort of idiopathic?   Dr. Kappos Of course, you would expect that this regulation of the immune system has this effect perhaps in the interaction of innate and adaptive immune system, but it's not yet clear what it means. The fact is that we didn't see other autoimmune diseases of relevance, only of increased incidence, and therefore it must be something unique to the skin. And fortunately, it's usually quite well manageable.    MSDF Is there a role for biomarkers? Can you discern anything here where it would indicate that you should use one drug versus another? Does daclizumab have anything unique about it that you can follow?    Dr. Kappos In the previous studies, we had had the observation that a certain subpopulation of immune cells – the so called CD56bright natural killer cells – are increased after initiation of treatment in those patients who seem to respond better to the drug. In this study, this response was seen in nearly all patients, and therefore it doesn't seem to differentiate good responders from perhaps not optimal responders. We have not finished the evaluation, and there were a series of biomarkers that had been evaluated during this trial. So I hope that we still will be able to find something.   MSDF In the oncology arena, sometimes adverse effects actually correlate with good efficacy. Did you see anything like that here?   Dr. Kappos No, there was no increased efficacy in those with cutaneous reactions, and otherwise the drug did not create problems. So you would not expect on a regular basis to experience adverse events. It's a different case than, for example, as compared to interferons where you have a very high frequency of flu-like symptoms. This is not the case here. So usually you would not realize, except for the injection that happens, that you take the drug.    MSDF Would there be any use to having a combination arm in a trial like this – interferon plus daclizumab?   Dr. Kappos The first studies had been as an add-on to interferon and have shown an effect as compared to interferon without this add-on, without daclizumab. At the moment, yes, it would be something that could be followed, but I don't really see what the ideal combination would be and then not really the necessity for this drug in contrast to other drugs that have similar or lower grades of efficacy.   MSDF I know it wasn't included in this trial, but can you compare the efficacy of daclizumab with anything currently available that people use?   Dr. Kappos I think it's very difficult to tell because it's always a problem to compare across studies because of different methodology; even the selection criteria formally are very similar may result in different populations of patients. So I would say from the grade of efficacy that was achieved it is certainly at least at the level of fingolimod or dimethyl fumarate. How it relates to natalizumab; if it could be used in patients who stopped natalizumab? These are questions that will have to be explored in the future.   MSDF Will you follow these patients further to see if there are any late effects either positive or negative?   Dr. Kappos Yes, most of them are in the extension studies and had the option to continue with open-label daclizumab. I think it's approximately 80% or more of the patients who decided to continue in this followup, and we will have a long-term followup for another four or five years.   MSDF From all of what you've said, what you make of this in terms of clinical significance, in terms of the future of this compound?   Dr. Kappos Well I think that it deserves to be approved and also to be one of the available options that we will have in the treatment of relapsing multiple sclerosis. If it has also an effect on progressive disease is something that my personally would be interested to know more about.   MSDF  Is there anything important to add that we haven't discussed?   Dr. Kappos The data now are consistent with a good data that were derived from the placebo controlled SELECT trial. And we have to take into account that they are against one established drug with approved efficacy. So it's more than that, and that's, of course, encouraging.    MSDF I suppose anything that gets you away from the side effects of interferon are a good thing.   Dr. Kappos Yes, anyway, of course, most other drugs that get you away from the side effects of interferons. But it seems, except for these cutaneous, manageable side effects, it seems also to be well tolerated. So a drug that could be used with a low threshold.    MSDF Is there tachyphylaxis? Does that side effect go away, or you just have to keep treating it the cutaneous?   Dr. Kappos It was different. It seems to be the case that if we had treated initially with steroids and then do not wait too long then it recovers, and then you can also resume treatment, or you can continue treatment. But there are the cases where we didn't continue treatment and then it result, but we didn't start again.   MSDF Very good. I appreciate it, thank you.   Dr. Kappos Thank you.   [transition music]   MSDF Thank you for listening to Episode Fifteen of Multiple Sclerosis Discovery. This podcast was produced by the MS Discovery Forum, MSDF, the premier source of independent news and information on MS research. MSDF’s executive editor is Robert Finn. Msdiscovery.org is part of the non-profit Accelerated Cure Project for Multiple Sclerosis. Robert McBurney is our President and CEO, and Hollie Schmidt is vice president of scientific operations.    Msdiscovery.org aims to focus attention on what is known and not yet known about the causes of MS and related conditions, their pathological mechanisms, and potential ways to intervene. By communicating this information in a way that builds bridges among different disciplines, we hope to open new routes toward significant clinical advances.   We’re interested in your opinions. Please join the discussion on one of our online forums or send comments, criticisms, and suggestions to editor@msdiscovery.org.   [outro music]          

Welcome to Episode Fifteen of The Epic Questions Podcast!! Today is Sunday, April 28, 2013. We've got questions about raiding, alts, making money, turtles, and much more. So grab a glass of noggenfogger, take a seat in your farm house, and enjoy the show.

Here we go for another week:Episode FifteenWill the world end this week? This is one of the topics we don't discuss. Some of the ones we do discuss are natureopathy, sex and dancing in front of the mirror in a disturbing manner.

Episode Fifteen of the continuing serial.  Verity comes home from the Masquerade, to be confronted by the spy, Aimee.Theme music is "Faithful" by The Shillas.Promo for Steampunk Spectactular.Get the first episode of this serial here.Direct Download

Episode Fifteen of the continuing serial.  More of the Doalis Masquerade.  Confusion with masks and identities.  Who would expect that?Theme music is "Faithful" by The Shillas.Incidental music is "Sunset Waltz" by Ken Kurland, courtesy of the Podsafe Music Network.Promo for the podiobook A Foolish World: Two Erotic NovellasGet the first episode of this serial here.Direct Download