Podcasts about T1

In this episode of Summoning Insight, we dive deep into one of the wildest weeks in competitive League of Legends across LCK, LPL, LEC, and LTA/LCS. If you love in-depth League of Legends esports analysis covering LCK playoffs, League of Legends analysis, T1 vs Gen.G, BLG vs TES, and LEC playoffs — this episode is a must-watch! Visit https://www.Kalshi.com and use promo code LFN. Make your first $100 worth of trades and you'll automatically receive a $10 bonus! Sign up for your $1 per month trial and start selling today at https://shopify.com/summoning  Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Assistant Professor Mohammad Mirhosseini (Caltech EE/APh) explains how his group built a mechanical quantum memory that stores microwave-photon quantum states far longer than typical superconducting qubits, and why that matters for hybrid quantum architectures. The discussion covers microwave photons, phonons, optomechanics, coherence versus lifetime (T2 vs. T1), current speed bottlenecks, and implications for quantum transduction and error mechanisms. The discussion centers on a paper from Mirhosseini's paper from December of 2024 titled, “A mechanical quantum memory for microwave photons,” detailing strong coupling between a transmon and a long‑lived nanomechanical oscillator for storage and retrieval of nonclassical states.GuestMohammad Mirhosseini is an Assistant Professor of Electrical Engineering and Applied Physics at Caltech, where his group engineers hybrid superconducting–phononic–photonic systems at millikelvin temperatures for computing, communication, and sensing. He completed his PhD at the University of Rochester's Institute of Optics and was a postdoc in Oscar Painter's group at Caltech before starting his lab. His recent team effort demonstrates mechanical oscillators as compact, long‑lived quantum memories integrated with superconducting circuits.Key topicsWhat “microwave photons” are and how qubits emit/absorb single microwave photons in circuit QED analogously to atoms and optical photons.Why “memory” is missing in today's quantum processors and how a dedicated long‑lived storage element can complement fast but dissipative superconducting qubits.Optomechanics 101: mapping quantum states between electrical and mechanical degrees of freedom, with phonons as the quantized vibrational excitations.T1 vs. T2: demonstrated order‑of‑magnitude gains in lifetime (T1) and more modest current gains in coherence (T2), plus paths to mitigate dephasing.Present bottleneck: state conversion between qubit and oscillator is about 100× slower than native superconducting operations, with clear engineering avenues to speed up.Quantum transduction: leveraging the same mechanical intermediary to bridge microwave and optical domains for interconnects and networking.Two‑level system (TLS) defects: shared decoherence mechanisms across mechanical oscillators and superconducting circuits and why comparing both can illuminate materials limits.Why it mattersHybrid architectures that pair fast processors with long‑lived memories are a natural route to scaling, and mechanical oscillators offer lifetimes far exceeding conventional superconducting storage elements while remaining chip‑integrable.. Demonstrating nonclassical state storage and retrieval with strong qubit–mechanics coupling validates mechanical oscillators as practical quantum memories and sets the stage for on‑chip transduction. Overcoming current speed limits and dephasing would lower the overhead for synchronization, buffering, and possibly future fault‑tolerant protocols in superconducting platforms.Episode highlightsA clear explanation of microwave photons and how circuit QED lets qubits create and absorb them one by one.Mechanical memory concept: store quantum states as phonons in a gigahertz‑frequency nanomechanical oscillator and read them back later.Performance today: roughly 10–30× longer T1 than typical superconducting qubits with current T2 gains of a few×, alongside concrete strategies to extend T2.Speed trade‑off: present qubit–mechanics state transfer is ~100× slower than native superconducting gates, but device design and coupling improvements are underway.Roadmap: tighter coupling for in‑oscillator gates, microwave‑to‑optical conversion via the same mechanics, and probing TLS defects to inform both mechanical and superconducting coherence.

Welcome to a new episode of Power Spike! This week, we discuss the LTA Playoffs and the status of LoL esports teams like FlyQuest, Cloud9, 100 Thieves, and Shopify Rebellion, T1's narrow victory over Dplus in the LCK Playoffs, League of Legends champion picks in the meta, the LPL Playoffs, and more! 

In this episode of Summoning Insight, Thorin and Yamato break down another intense week of League of Legends esports action, covering everything from the LPL and LCK playoffs to the heated drama surrounding Bwipo and FlyQuest. The duo dives deep into FlyQuest's dominant run, Bwipo's controversial comments, and the ripple effects across the LoL competitive scene. They also analyze standout performances, strategic drafting in the Fearless format, and the challenges teams face ahead of Worlds 2025. Expect sharp insights, bold takes, and plenty of debate about player reputations, team culture, and how mental resilience shapes championship runs. Beyond the Bwipo controversy, the show dissects key playoff series across major regions, including T1's shaky showing in the LCK, the rise of underdog teams in the LPL, and high-stakes matchups in the LEC featuring KOI, Fnatic, and Karmine Corp. With expert commentary grounded in years of esports experience, Summoning Insight delivers the context and storytelling that fans of LoL crave. Whether you're here for the strategy talk, the inside scoops, or the drama that shakes the pro scene, this episode connects you to the heart of competitive League of Legends. If you're looking for unfiltered insights, bold predictions, and in-depth playoff previews, this is an episode you won't want to miss! Protect your online privacy TODAY by visiting https://ExpressVPN.com/summoning and you can get up to four extra months FREE. Upgrade your wallet today! Get 10% Off Ridge with code SI at https://www.Ridge.com/SI Get up to 10 FREE meals and a free item for life at https://www.hellofresh.com/lfn10fm Go to https://www.buyraycon.com/LFN TODAY to get up to 20% off sitewide!

In the second episode from race week in Nice, host Matt Lieto connects with another trio of top contenders for the IRONMAN World Championship title: Sam Laidlow, Marten van Riel, and Matthew Matthew MarquardtFirst, defending Nice champion Sam Laidlow reflects on a challenging year that started with a reactivation of the Epstein-Barr virus. He explains how the forced rest shifted his perspective from chasing numbers to focusing on quality, health, and a more holistic preparation. This new approach led to breakthrough performances on surprisingly low training volume, giving him a newfound "inner peace and confidence" as he looks to defend his title on French soil.Next, Marten van Riel opens up about his turbulent and "panicky" build-up to his first full-distance World Championship, which included a significant ankle injury that limited him to a four-week run block and a minor crash on the course just days before the race. Despite the setbacks, the Belgian Olympian discusses the freedom that comes from lowered expectations and his excitement to race on a course he feels is perfectly suited to his strengths.Finally, American Matthew Marquardt details his season of two halves, from frustrating early-season results to dominant victories at IRONMAN Cairns and Lake Placid. The medical student gives a fascinating deep-dive into the physiological cause of the quad spasms that have affected him in T1 and explains the strategic evolution in his racing—learning to conserve energy on the bike to unleash his now formidable run, which he believes is the key to competing with the best in the world.

Transitions can make or break your race, and Transition 1 is often where valuable seconds slip away. In this episode, we take a deep dive into the ins and outs of T1 with Coaches Jeff Raines and Jenn Reinhart. From sighting the swim exit and navigating the chaos of the transition area, to smart gear staging and finding your bike fast, they share practical tips and real-world strategies to streamline your next race. Plus, enjoy some unforgettable stories from their own triathlon journeys. Whether you're a first-timer or a seasoned racer, this episode will help you move from swim to bike like a pro.

Hello fellow noble Knights and such. Here it is, the long awaited Imperial Knight Codex Review!This is a book close to my heart, as many know knights are one of my main factions for the past year and i have had a fair bit of time to muse upon it's workings. Le'ts just say the overall power level is likely down, but the plays you can make as a knight player are Way up.For this review i was joined by the brilliant Jordan McGreggor who is currently ranked No1 in the ITC in Australia in addition to representing Australia at the recent WTC. He is Mr Armiger himself and brings nuance and insights for days.Hope you love it!PS apologies for any confusion, the PDF i reviewed was worded a little differently than release and you WILL get your quality from T1!

Dr. Sumanta (Monty) Pal and Dr. Petros Grivas discuss innovative new intravesical therapies and other recent advances in the treatment of non-muscle invasive bladder cancer. TRANSCRIPT Dr. Sumanta (Monty) Pal: Hello and welcome. I'm Dr. Monty Pal here at the ASCO Daily News Podcast. I'm a medical oncologist and professor and vice chair of academic affairs at the City of Hope Comprehensive Cancer Center in Los Angeles. And I'm really delighted to be your new host here. Today's episode is going to really sort of focus on an area near and dear to my heart, something I actually see in the clinics, and that's bladder cancer. We're specifically going to be discussing non-muscle invasive bladder cancer, which actually comprises about 75% of new cases. Now, in recent years, there's been a huge shift towards personalized bladder-preserving strategies, including innovative therapies and new agents that really are reducing reliance on more primitive techniques like radical cystectomy and radiation therapy. And I'm really excited about this new trend. And really at the forefront of this is one of my dear friends and colleagues, Dr. Petros Grivas. He's a professor in the Department of Medicine and Division of Hematology Oncology at the University of Washington. It's going to take a while to get through all these titles. He's taken on a bunch of new roles. He is medical director of the International Program, medical director of the Local and Regional Outreach Program, and also professor in the Clinical Research Division at the Fred Hutch Cancer Center. Petros, welcome to the program. Dr. Petros Grivas: Thank you so much, Monty. It's exciting for me to be here. Dr. Sumanta (Monty) Pal: Just FYI for our audience, our disclosures are available in the transcript of this episode.  We're going to get right into it, Petros. Non-muscle invasive bladder cancer, this is a really, really challenging space. We see a lot of recurrence and progression of the disease over time, about 50% to 70% of patients do have some recurrence after initial treatment, and about 30% are ultimately going to progress on to muscle-invasive or metastatic disease. Now, I will say that when you and I were in training, non-muscle invasive bladder cancer was something that was almost relegated to the domain of the urologist, right? They would use treatments such as BCG (Bacillus Calmette-Guérin) in a serial fashion. It was rare, I think, for you and I to really enter into this clinical space, but that's all changing, isn't it? I mean, can you maybe tell us about some of the new therapies, two or three that you're really excited about in this space? Dr. Petros Grivas: Monty, you're correct. Traditionally and conventionally, our dear friends and colleagues in urology have been managing patients with non-muscle invasive bladder cancer. The previous term was superficial bladder cancer. Now, it has changed, to your point, to non-muscle invasive bladder cancer. And this has to do with the staging of this entity. These tumors in superficial layers of bladder cancer, not invading the muscularis propria, the muscle layer, which makes the bladder contract for urine to be expelled. As you said, these patients have been treated traditionally with intravesical BCG, one of the oldest forms of immunotherapy that was developed back in the 1970s, and this is a big milestone of immunotherapy development. However, over the years, in the last 50 years, there were not many options for patients in whom the cancers had progression or recurrence, came back after this intravesical BCG. Many of those patients were undergoing, and many of them still may be undergoing, what we call radical cystectomy, meaning removal of the bladder and the lymph nodes around the bladder. The development of newer agents over the last several years has given the patients the option of having other intravesical therapies, intravesical meaning the delivery of drugs, medications inside the bladder, aiming to preserve the bladder, keep the bladder in place. And there are many examples of those agents. Just to give you some examples, intravesical chemotherapy, chemotherapy drugs that you and me may be giving intravenously, some of them can be given inside the bladder, intravesical installation. One example of that is a combination of gemcitabine and docetaxel. These drugs are given in sequence one after the other inside the bladder, and they have seen significant efficacy, good results, again, helping patients keeping the bladder when they can for patients with what we call BCG unresponsive non-muscle invasive bladder cancer. And again, there's criteria that the International Bladder Cancer Group and the FDA developed, how to define when BCG fails, when we have BCG unresponsive non-muscle invasive bladder cancer. Dr. Sumanta (Monty) Pal: And we're actually going to get into some of the FDA requirements and development pathways and so forth. What I'm really interested in hearing, and I'm sure our audience is too, are maybe some of the new intravesical treatments that are coming around. I do think it's exciting that the gemcitabine and docetaxel go into the bladder indeed, but what are some of the top new therapies? Pick two or three that you're excited about that people should be looking out for in this intravesical space. Dr. Petros Grivas: For sure, for sure. In terms of the new up-and-coming therapies, there are a couple that come to mind. One of them is called TAR-200, T-A-R 200. This agent is actually a very interesting system. It's an intravesical delivery of a chemotherapy called gemcitabine, the one that I just mentioned a few minutes ago, that is actually being delivered through what we call a pretzel, which is like a rounded [pretzel-shaped] structure working like an osmotic pump, and that is being delivered inside the bladder intravesically by urologists. And this drug is releasing, through the osmotic release mechanism, this chemotherapeutic drug, gemcitabine, inside the bladder. And this can be replaced once every 3 weeks in the beginning. And the data so far from early-phase trials are really, really promising, showing that this agent may be potentially regulatory approved down the road. So TAR-200 is something to keep in mind. And similarly, in the same context, there is a different drug that also uses the same mechanism, and this osmotic release, this pretzel, it's just encoded with a different agent. The different agent is an FGFR inhibitor, a target therapy called erdafitinib, a drug that you and me may give in patients with metastatic urothelial carcinoma if they have an FGFR3 mutation or fusion. And that drug is called TAR-210. Dr. Sumanta (Monty) Pal: And can I ask you, in that setting, do you have to have an FGFR3 mutation to receive it? Or what is the context there? Dr. Petros Grivas: So for TAR-210, TAR-2-1-0, usually there is a checking to see if there is an FGFR3 mutation or fusion. And the big question, Monty, is do we have adequate tissue, right? From a limited tissue on what we call the TURBT, right, that urologists do. And now there is a lot of development in technology, for example, urine circulating tumor DNA to try to detect these mutations in the urine to see whether the patient may be eligible for this TAR-210. Both of those agents are not FDA approved, but there are significant promising clinical trials. Dr. Sumanta (Monty) Pal: So now let's go to a rapid-fire round. Give us two more agents that you're excited about in this intravesical space. What do you think? Dr. Petros Grivas: There is another one called cretostimogene. It's a long name. Dr. Sumanta (Monty) Pal: They really make these names very easy for us, don't they? Dr. Petros Grivas: They are not Greek names, Monty, I can tell you, you know. Even my Greek language is having trouble pronouncing them. The cretostimogene, it's actually almost what we call a growth factor, a GM-CSF. The actual name of this agent is CG0070. This is a replicating mechanism where GM-CSF is replicating in cells. And this agent has shown significant results again, like the TAR-200, in BCG unresponsive non-muscle invasive bladder cancer. I would say very quickly, two agents that actually were recently approved and they're already available in clinical practice, is nadofaragene firadenovec, another long name. That's a non-replicating vector that has the gene of interferon alfa-2b that stimulates the immune system in the bladder. It's given once every 3 months. And the last one that was, as I mentioned, already FDA approved, it's an interleukin-15 superagonist. It's another long name, which is hard to pronounce, but I will give it a try. It's a drug that was recently actually approved also in the UK. The previous name was N-803. It's given together with BCG as a combination for BCG unresponsive non-muscle invasive bladder cancer. Dr. Sumanta (Monty) Pal: This is a huge dilemma, I think, right? Because if you're a practicing, I'm going to say urologist for the moment, I guess the challenge is how do you decide between an IL-15 superagonist? How do you decide between a pretzel-eluting agent? How do you decide between that and maybe something that's ostensibly, I'm going to guess, cheaper, like gemcitabine and docetaxel? What's sort of the current thinking amongst urologists? Dr. Petros Grivas: Multiple factors play into our account when the decision is being made. I discuss with urologists all the time. It's not an easy decision because we do not have head-to-head comparisons between those agents. As you mentioned, intravesical chemotherapy with gemcitabine and docetaxel has been used over the years and this is the lowest cost, I would say, the cheapest option with good efficacy results. Obviously, the nadofaragene firadenovec every 3 months and the interleukin-15 superagonist, N-803, plus BCG have also been approved. The question is availability of those agents, are they available? Are they reimbursed? Cost of those agents can come into play. Frequency of administration, you know, once every 3 months versus more frequent. And of course, the individual efficacy and toxicity data, preference of the patients; sometimes the provider, the urologist, may have something that they may be more familiar with. But we lack this head-to-head comparison. Of course, I want to make sure I mention that radical cystectomy may still be the option for appropriate patients. So that complicates also the decision making and has to be individualized, customized, and personalized, taking into account all those factors. And there is not one size fitting all. Dr. Sumanta (Monty) Pal: So I think we discussed five intravesical therapies. As you point out, and you know, I'm going to get some calls about this: I think I referred to radical cystectomy as being a more primitive procedure. Not true at all. I think it's something that still is, you know, a mainstay of management in this disease space. But I guess it gets even more complicated, am I right, Petros? Because now we have systemic therapies that we can actually apply in this non-muscle invasive setting for at this point, refractory disease. Can you maybe just give us a quick two-minute primer on that? Dr. Petros Grivas: Absolutely, and systemic therapies now come into play, as you said. And a classical example of that, Monty, came from the KEYNOTE-057 trial that we published about 6 years ago. This is intravenous pembrolizumab, given intravascularly, intravenously, as opposed to the previously discussed intravesical administration of agents. Pembrolizumab was tested in that KEYNOTE-057 trial and showed efficacy about, I would say, one out of five patients, about 20%, had a complete response of the tumor in the bladder in a year after starting the treatment. Again, it's hard to compare across different agents, but obviously when we give something intravenously, there is a risk of toxicity, side effects systemically, what we call immune-related adverse events. And this can also play in the decision making, right? When you have intravesical agents versus intravascular agents, there is different toxicity profiles in terms of systemic toxicity. But intravenous pembrolizumab has been an option, FDA approved, since, if I remember, it was early 2020 when this became FDA approved. There are other agents being tested in this disease, but like atezolizumab through the SWOG study that Dr. Black and Dr. Singh led, but atezolizumab is not FDA approved for this indication. Again, this is for BCG unresponsive, high-risk, non-muscle invasive bladder cancer. Dr. Sumanta (Monty) Pal: So maybe teach us how it works, for instance, at an expert center like the Fred Hutch. When you see a patient with non-muscle invasive bladder cancer, there's obviously the option of surgery, there's the intravesical therapies, which I imagine the urology team is still really at the helm of. But then, I guess there has to be consideration of all options. So you've got to bring up systemic therapy with agents like pembrolizumab. In that context, are you involved that early on in the conversation? Dr. Petros Grivas: That's a great discussion, Monty. Paradigm is shifting as we mentioned together. The urologists have been treating these patients and still they are the mainstay of the treaters, the managers in this disease. But medical oncologists come to play more and more, especially with the FDA approval of intravenous pembrolizumab about 5 years ago [GC1]  [KM2] . We have the concept of multidisciplinary bladder cancer clinic here at Fred Hutch and University of Washington. This happens every Tuesday morning, and we're very excited because it's a one-stop shop for the patients. We have the urologist, a medical oncologist, radiation oncologist, and experts from radiology and pathology, and we all review cases specifically with muscle-invasive bladder cancer. But every now and then, we see patients with BCG unresponsive non-muscle invasive bladder cancer. And this is where we discuss and we talk to the patient about pros and cons of all those options. And that's a classic example where medical oncologists may start to see those patients and offer their input and expertise. In addition to that, sometimes we have clinical trials, we may see these patients because there are systemic agents that may be administered in this setting. We have the SunRISe trial program that includes also a systemically administered checkpoint inhibitor. So that's another example where we see patients either in the context of multi-clinic or in individual solo clinics to counsel the patients about the pros and cons of the systemically administered agents in the context of clinical trials. Usually checkpoint inhibitors are the class of agents that are being tested in this particular scenario. Dr. Sumanta (Monty) Pal: I can see a scenario where it's really going to require this sort of deep dive, much in the way that we do for prostate cancer, for instance, where the medical oncologist is involved very early on and planning out any sort of systemic therapy component of treatment or at the very least, at least spelling out those options. I think it's going to be really interesting to see what this space looks like 5 or 10 years down the road. In closing, I wanted to go through something that I think is so different in this space, at least for the time being, and that is the paradigm for FDA approval. When you and I have our fellows in the clinics, we always say, “Look, you know, the paradigm in this disease and that disease and the other disease needs to be phase 3 randomized trials, right? Big thousand patient experiences where you're testing clinical endpoints.” That's tough in non-muscle invasive bladder cancer, right? Because thankfully, outcomes can actually be quite good, you know, in this setting, right? It's tough to actually estimate overall survival in some of these early-stage populations. Tell me what the current regulatory bar is, and this is a tough thing to do in 2 minutes or less but tell me where you see it headed. Dr. Petros Grivas: You alluded to that before, Monty, when I was giving the background and we talked about the regulatory approval. And I have to very quickly go back in time about 10 years ago because it's important for context that can help us in other disease types too. We had workshops with the FDA and the NCI with the help of the International Bladder Cancer Group and other colleagues. And we try to define a framework, what endpoints are meaningful for those patients in this disease. It was a multidisciplinary, multiple stakeholders meeting, where we tried to define what is important for patients. What are the available agents? What are the trial designs we can accept? And what are the meaningful endpoints that the regulatory agencies can accept for regulatory approval? And that was critical in that mission because it allowed us to design clinical trials, for example, single-arm trials in a disease where there was no standard of care. There was intravesical valrubicin and chemotherapy anthracycline that was approved for many years, but was not practically used in clinical practice, despite being approved, the valrubicin. And because of that, the FDA allowed these single-arm trials to happen. And obviously the endpoint was also discussed in that meeting. For example, for carcinoma in situ, complete response, clinical complete response, because the bladder remains intact in many patients, clinical complete response was a meaningful primary endpoint, also duration of response is also very important. So what is the durable clinical complete response in 1 year or 18 months is relevant. And when you have papillary tumors like Ta or T1 with CIS, for papillary tumors, event-free survival becomes one of the key endpoints and you look at it over time, for example, at 12 or 18 months, what is the event-free survival? So clinical complete response, duration of response, event-free survival, depending on the CIS presence or papillary tumors, I think these are endpoints that have allowed us to design those trials, get those agents approved.  Now, the question going forward, Monty, and we can close with that is, since now we have the embarrassment of riches, many more options available compared to where we were 6 and 7 years ago, is now the time to do randomized trials? And if we do randomized trials, which can be the control group? Which of those agents should be allowed to be part of the control group? These are ongoing discussions right now with the NCI, with other agencies, cooperative groups, trying to design those trials and move forward from here.[GC3]  Dr. Sumanta (Monty) Pal: Well, it's awesome to have you here on the program so we can get some early looks into some of these conversations. I mean, clearly, you're at the table at a lot of these discussions, Petros. So I want to thank you for sharing your insights with us today. This was just tremendous. Dr. Petros Grivas: Thank you, Monty. You know, patients in the center, I just came back from the Bladder Cancer Advocacy Network meeting in Washington, D.C., and we discussed all those questions, the topics you very eloquently mentioned and asked me today, and patients gave us great feedback and patients guide us in that effort. Thank you so, so much for having me and congratulations for the amazing podcast you're doing. Dr. Sumanta (Monty) Pal: Oh, cheers, Petros, thanks so much.  And thank you to the listeners who joined us today. If you really like the insights that you heard on this ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Thanks, everyone. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.   Find out more about today's speakers:      Dr. Sumanta (Monty) Pal  @montypal  Dr. Petros Grivas @PGrivasMDPhD   Follow ASCO on social media:     @ASCO on Twitter    ASCO on Bluesky   ASCO on Facebook     ASCO on LinkedIn     Disclosures:    Dr. Sumanta (Monty) Pal:   Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview  Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical  Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis  Dr. Petros Grivas: Consulting or Advisory Role: Merck, Bristol-Myers Squibb, AstraZeneca, EMD Serono, Pfizer, Janssen, Roche, Astellas Pharma, Gilead Sciences, Strata Oncology, Abbvie, Bicycle Therapeutics Replimune, Daiichi Sankyo, Foundation Medicine, Bicycle Therapeutics, Eli Lilly, Urogen Pharma, Tyra Biosciences Research Funding (Inst.): Bristol-Myers Squibb, Merck, EMD Serono, Gilead Sciences, Acrivon Therapeutics, ALX Oncology, ALX Oncology, Genentech Travel, Accommodations, Expenses: Gilead Sciences

In this episode of Summoning Insight, Thorin and Yamato dive deep into the state of League of Legends across multiple regions, starting with the chaos surrounding the LEC Playoffs. They tackle Riot's scheduling controversies, format missteps, and break weeks, then break down the strengths and weaknesses of top contenders like G2, Fnatic, Karmine Corp, and KOI. Expect sharp takes on G2's perfect split, Fnatic's month-long break before playoffs, KC's internal drama, and whether KOI can mount another title or a LoL Worlds 2025 run. The conversation then moves globally, with heated analysis of the LCK Playoffs picture and GenG's historically dominant regular season, plus whether T1 can challenge them. In LTA North, the hosts unpack 100 Thieves' surprise takedown of Team Liquid, Cloud9's shaky form against lower-tier teams, and the looming dominance of FlyQuest. The episode also previews the high-stakes LPL playoffs and features candid opinions on player form, team building, and what it takes to perform on stage in the most competitive LoL esports environments. If you're looking for unfiltered insights, bold predictions, and in-depth playoff previews, this is an episode you won't want to miss!Visit https://prizepicks.onelink.me/LME0/SUMMONING and use code SUMMONING and get $50 in lineups when you play your first $5 lineup! Last Free Nation's new collaboration t-shirt with Into the AM is out now! Equip yourself with this high-quality shirt (featuring a familiar insignia) now! While you're there, you can also shop the Into the AM Labor Day Sale! Items are up to 50% sitewide until the 7th of September. This is in addition to the 10% off you always get by using our link: https://intotheam.com/LFN-tee2 Go to https://www.buyraycon.com/LFN TODAY to get up to 20% off sitewide! Control Body Odor ANYWHERE with Mando and get 20% off + free shipping with promo code SUMMONING at shopmando.com!

Scott and Joris pour over the European league phase draws for Belgian clubs and discuss a terrible week for Anderlecht on and off the park + a change of T1 at Standard and they review a busy mercato week.

Esportmaníacos 2363: En el programa de hoy hemos visto las declaraciones del Commissioner de la LEC sobre el formato y por qué las cosas se han llevado de la manera que se han llevado este año. También hemos visto el T1 vs Gen G en el cuál el campeón del MSI se ha vuelto a imponer y hemos tocado algunos temas de actualidad como el nuevo fichaje de NAVI LEC o la Final Four de Superliga Domino's APÓYANOS AQUÍ https://www.patreon.com/Esportmaniacos https://www.twitch.tv/esportmaniacos 🔁Nuestras redes🔁 https://twitter.com/Esportmaniacos https://www.tiktok.com/@esportmaniacos 💙Referido de AMAZON: https://amzn.to/36cVx3g 00:00:00 - Intro 00:18:20 - Gen G vuelve a ganarle a T1 00:38:15 - Representantes del Game Changers 00:40:45 - Riot responde sobre el futuro de la LEC 01:29:00 - NAVI ficha su head coach para 2026 01:34:30 - Rumores de scrims de LEC 01:44:40 - Repaso de la Final Four de SLD

Episode 289: Adrian is joined again by our head of New Product Development, Paul Adams, to explore the complexity of plastic injection mold tooling and what it takes to go from tooling design to mass production of plastic parts. They explore the full journey, from DFM and tool design through trial runs (T0, T1, T2) to final sign-off and mass production. Along the way, they highlight common pitfalls, golden samples, and why rushing into production can be a costly mistake. You'll love this episode if you're developing plastic products, as it will help you to avoid surprises and manage expectations in the new product introduction (NPI) process.   Episode Sections: (00:00:03) Introduction to episode 289 (00:00:13) Adrian welcomes back Paul Adams (00:00:35) Today's topic: plastic injection mold tooling and its complexity (00:01:11) From DFM to mass production – the journey explained (00:02:01) Why tooling is expensive and misunderstood (00:02:48) The role of DFM (Design for Manufacturing) in tooling (00:05:13) Customer involvement and asking the right questions (00:05:19) Tooling design: bolster set vs. core and cavity (00:06:21) Material procurement and standard vs. custom components (00:09:01) Machining the tool: CNC, EDM, wire cutting, polishing (00:11:12) Metal safe condition and first fitting (00:11:59) The T0 trial run explained (00:13:42) First look at molded parts and making big adjustments (00:15:09) The T1 trial run with virgin polymer (00:15:57) Inspection reports and customer sign-off (00:18:00) Surface texturing between T1 and T2 (00:18:14) T2 trial – final tuning and sign-off preparation (00:19:02) Phase gates link: tooling to mass production (00:20:19) Golden samples and color consistency checks (00:22:02) Why being on the ground in China helps with sign-off (00:23:23) Limit samples and customer approval process (00:23:55) The importance of T0–T2 for expectation management (00:24:58) Why not to rush into mass production (00:25:02) Links to prototypes and phase gate methodology (00:26:05) Don't sign off tooling until everything is consistent (00:26:59) Moving into mass production and ongoing monitoring (00:28:28) Tool lifespan and long-term considerations (00:28:48) Wrapping up: intricacies of tooling complexity (00:29:16) Sofeast NPI guide and related video resources (00:30:16) Looking ahead: polymers and material selection (00:30:45) Closing remarks and call to action   Related content... How We Work With You On New Product Development & Manufacturing Projects - Agilian NPI Process Tooling Management for Plastic Injection Molds in China 7 Key NPI Tasks Before Production The Conundrum of Investing in Tooling Before a Final Prototype Inside the Tooling: Common Plastic Injection Mold Components Explained Understanding Plastic Injection Mold Tooling Complexity, from DFM to T1, When Manufacturing in China (Video) Get in touch with us Connect with us on LinkedIn Contact us via Sofeast's contact page Subscribe to our YouTube channel Prefer Facebook? Check us out on FB

First Pick   Ultimate Guard Roundup Statement on Generative AI: https://bsky.app/profile/ultimateguard.bsky.social/post/3lwwcrte4l22b Harry Potter Boxes Removed: https://cdn.discordapp.com/attachments/410942703623208960/1408125065328984164/Screenshot_2025-08-21_at_17.25.23.png?ex=68b08329&is=68af31a9&hm=13ac080905333d58e4a63819c0f680ed72f072b02b952d2699169dd94b9750cf& Rhystic Studies Resigns: https://cdn.discordapp.com/attachments/410942703623208960/1410272968906637413/Screenshot_20250827-101320.png?ex=68b06a8d&is=68af190d&hm=fe3cf0ef64a5274a094c18de8b24dd294ff8a9c24f35b7a3330338be649d2db5& https://bsky.app/profile/rhysticstudies.bsky.social/post/3lxf7g2rbl22y   Gather the Townsfolk   EDHREC's Survey: https://bsky.app/profile/edhrec.com/post/3lxajold4o626 https://bsky.app/profile/veggiewagon.bsky.social/post/3lxbed5qf6c2m   Desperate Ravings   Vivi Cauldron Dominates NRG Series: https://bsky.app/profile/emmapartlow.com/post/3lx3tcja6y22i Timing of Next Scheduled B&R Announcement: https://bsky.app/profile/themaverickgirl.bsky.social/post/3lxbdtwjg2224   Maro Talks UB (Again (Again (Again))): https://markrosewater.tumblr.com/post/792626213105647616/i-feel-like-its-a-little-disingenuous-to-continue   Splash Damage   Hareruya Suspends Shipping to US: https://bsky.app/profile/fireshoes.bsky.social/post/3lxcoprcrd22c   The Finisher   The 2025 ESports Awards presented by T1 happened last week, and they included awards for the last decade. Some of the honors went to player of the decade Faker, on-air talent of the decade Sjokz (“shocks”), and game of the decade League of Legends. Now, obviously T1 is a LoL company, so tell me: if you were giving an award in gaming for the last decade who would you like to see honored?

In this episode:Some background on Zappi and how it provides brands like PepsiCo, McDonald's and Heineken with consumer data and insights to help fuel their advertising (01:00)A review of the celebrity MVNO sector and some other product areas endorsed or owned by celebrities (3:30)Celebrity-focused ads are distinctive, but they don't necessarily provide a near-term sales bump (7:45)How and why the effectiveness of celebrity advertising varies by age group (21:40)Brand recall also differs among age groups (27:30)How Trump Mobile and its golden T1 phone might resonate in the market (30:00)Other ways celebrity MVNOs may try to stand out in the market (35:40) Hosted on Acast. See acast.com/privacy for more information.

This week on Summoning Insight, we're tackling the big talking points in the world of League of Legends esports! First, we dive into the latest Esports Awards: was Faker the only choice for Player of the Decade? We debate the winners and the merits of the selection process. Then, we dissect the turbulent LCK! What's going on with T1? Can GenG be stopped? We break down KT's SHOCKING victory over T1 and what it means for both teams, T1's recent struggles and their crucial upcoming matches, and Gen G's DOMINANCE: their secret sauce, adaptable playstyle, and individual player brilliance (Chovy & Ruler!). We go BEHIND THE SCENES and explore the vital role of COACHING in esports. Learn about the challenges of managing star players, building trust, and creating a winning team environment. Yamato shares personal experiences and insights from his own coaching career. Don't miss out on this packed episode, including analysis from the latest matches from LTA and LPL! Tune in to get your Summoning Insight fix! Sign up for your $1 per month trial and start selling today at https://shopify.com/summoning Shop the Into the AM Labor Day Sale! Items are up to 50% sitewide until the 7th of September. This is in addition to the 10% off you always get by using our link: https://intotheam.com/lfn Eat smart with Factor! Go to https://FactorMeals.com/lfn50off and use code lfn50off to get 50% off your first box, plus Free Breakfast for 1 Year.

AppleInsider spotted the latest bizarre wrinkle to this story, which is that the actual phone still does not exist. The publication noticed that promotional images for T1 all show different smartphones that appear to be tweaked in a photo editor to look gold. While the website shows a badly edited image of what appears to be a Revvl 7 Pro 5G phone, an Instagram ad seems to depict an iPhone 16 Pro Max, again with the company's branding overlaid. A third confusing image edit was posted on X earlier this week. That photo shows a Samsung Galaxy S25 Ultra equipped with a case made by Spigen. The South Korean accessory company's logo can be seen behind the render of an American flag. In other news, Germany-based search engine and browser nonprofit Ecosia is the latest party to make an offer for Google's Chrome. Questions about Chrome's fate have been swirling since the news that the Department of Justice would push for Google to sell the browser after the ruling that the company's search engine business constituted a monopoly. And the National Highway Traffic Safety Administration just announced an investigation into Tesla regarding its Autopilot and Full Self-Driving systems. That's according to a report by Electrek. The road safety regulator says the probe involves inconsistencies with how the company reports crashes regarding the aforementioned systems. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Thorin and Yamato discuss the state of T1 compared to LCK rival GenG, where Fnatic stands in the LEC, Shopify Rebellion's massive upset over Cloud9 in the LTA, IG's thrilling surprise victory over BLG in the LPL, and more! Go to https://www.buyraycon.com/lfn TODAY to get up to 20% off the fan-favorite Everyday Earbuds Classic! Control Body Odor ANYWHERE with Mando and get 20% off + free shipping with promo code SUMMONING at shopmando.com!

This episode is a thyroid deep dive — a jam-packed conversation with Dr. Gary E. Foresman, MD of MiddlePathMedicine.com. We tackle the biggest myths, mistakes, and misunderstandings in thyroid treatment today. Here's what we cover: The FDA Ban on Natural Desiccated Thyroid (NDT): What it really means for patients. Medication Before Labs: Why you should never take T4/T3 or T3-only meds before a thyroid test. Dosing Myths Debunked: Why no practitioner should put an arbitrary limit on T4 or T3 dosing. Beyond T4 & T3: Do T1, T2, and calcitonin in NDT actually matter? Are T2 supplements worthwhile? Failed Research: How flawed medical studies have left thyroid patients in the dust. The TSH Suppression Myth: Why suppressed TSH on T4/T3 combos or T3-only therapy is NOT dangerous, doesn't cause arrhythmias or osteoporosis, and why outdated T4-only protocols from 30 years ago created decades of false fear. Reverse T3: Why this is a critical — and often ignored — test. Blood Sugar & Thyroid Hormones: How food satiety and glucose fluctuations can masquerade as thyroid issues (like tachycardia), and why it's not always your thyroid to blame. If you've ever been confused, dismissed, or gaslit about your thyroid health, this episode will give you the clarity (and firepower) you need! Visit MiddlePathMedicine.com to learn more about Dr. Foresman.   FREEBIES: Free Thyroid Guide + Video Series: https://www.elleruss.com/thyroid-guide Free Confidence eBook & Workbook: https://www.elleruss.com/7secrets Elle's newsletter: https://www.elleruss.com/newletter   #theellerussshow

T1 Energy and Corning today announced a new partnership to boost the U.S. solar supply chain. T1 will source hyper-pure polysilicon and solar wafers made by Corning at its plant in Michigan. Starting later next year, Corning wafers will be delivered to T1's G2_Austin solar cell facility, which is currently under development. The cells will then be used to make solar modules at T1's operational G1_Dallas site.T1's G2_Austin 5 GW Solar Cell Facility is an $850 million project. According to the company, the project is enabled by the Trump Administration's tariffs and other policies that support American manufacturing. The facility is expected to begin producing cells by the end of 2026 and create up to 1,800 full-time jobs.

Esportmaníacos 2352: En el programa de hoy hemos hablado de que vuelve la LEC ya que tendremos duelo de junglas españoles: Elyoya vs Thayger. También tendremos el clásico entre G2 y Fnatic el domingo. Hemos tocado otros temas como el COO de T1 hablando del futuro del club y hemos hecho un pequeño repaso a los partidos destacados del fin de semana en China y Corea. APÓYANOS AQUÍ https://www.patreon.com/Esportmaniacos https://www.twitch.tv/esportmaniacos 🔁Nuestras redes🔁 https://twitter.com/Esportmaniacos https://www.tiktok.com/@esportmaniacos 💙Referido de AMAZON: https://amzn.to/36cVx3g 00:00:00 - Intro y debate sobre la LEC 00:32:00 - T1 contra HLE en la LCK 00:43:30 - Partidos destacados de la LPL 00:46:15 - El COO de T1 habla del futuro del equipo 01:06:25 - Previa de la LEC 01:29:18 - Clásico: G2 vs FNC 01:50:00 - Primer finalista de SLD

Esportmaníacos 2351: En el programa de hoy hemos hablado de las palabras de Jojopyun en EUphoria hablando del nivel de la región, del T1 contra HLE que tendremos en la LCK y además hemos contado con la visita de Disgrace para hablar de Superliga Domino's y de su opinión del estado actual de la LEC. APÓYANOS AQUÍ https://www.patreon.com/Esportmaniacos https://www.twitch.tv/esportmaniacos 🔁Nuestras redes🔁 https://twitter.com/Esportmaniacos https://www.tiktok.com/@esportmaniacos 💙Referido de AMAZON: https://amzn.to/36cVx3g 00:00:00 - Intro en la que hablamos de varias noticias cortas 00:22:00 - Nos visita Disgrace 00:52:20 - Las declaraciones de Jojopyun 01:17:30 - Cambio de las normativa de la LEC 01:30:30 - Planes a futuro del roster de T1 01:39:38 - Repaso de la LPL 01:45:00 - Actualidad en la LCK y el posible estadio de T1

IWDominate, Jamada, and dGon discuss the latest Riot Dev update and Drew Levin's smackdown of smurfs and boosters, a set of fans sending a disturbing message to T1, the drama involving KC Vladi and Kameto, Palafox flaming his critics, the latest results from the LEC, and more! Get 50% off FACTOR meals at https://www.factormeals.com/powerspike50off with code powerspike50off. High-quality, never-frozen meals delivered to your home!

Thorin and Yamato discuss the latest drama revolving around T1, KC Mid Laner Vladi lashing out against the team's fanbase, the state of Humanoid's career. the latest results from the LEC and LPL, and more! Sign up for your $1 per month trial and start selling today at https://shopify.com/summoning ​Start reliving your favorite memories by visiting https://www.AuraFrames.com to get $35 off on Aura's best-selling Carver Mat frames by using promo code SUMMONING at checkout! Get up to 10 FREE meals and a free item for life at https://www.hellofresh.com/lfn10fm Get 10% Off your entire order & take advantage of Ridge's Annual Sweepstakes by going to https://www.Ridge.com/SI

Esportmaníacos 2349: En el programa de hoy hemos hablado de las nuevas noticias sobre el drama de Vladi. Kameto se ha pronunciado sobre el tema igual que Targamas en su propio stream. También hemos hablado de las skins de T1, cuya fecha ya ha sido anunciada y hemos tenido un debate sobre quién ha vuelto más fuerte del internacional, si Movistar KOI o G2 Esports. APÓYANOS AQUÍ https://www.patreon.com/Esportmaniacos https://www.twitch.tv/esportmaniacos 🔁Nuestras redes🔁 https://twitter.com/Esportmaniacos https://www.tiktok.com/@esportmaniacos 💙Referido de AMAZON: https://amzn.to/36cVx3g 00:00:00 - Intro 00:16:20 - Las fechas de las skins de T1 00:28:33 - El WASD en el LoL 00:53:34 - ¿Quién viene mejor del Top 4? 01:40:00 - Quinteto de la semana

En el programa de hoy hemos hablado de la vuelta al ruedo de G2 y MKOI a la LEC, del clásico de la LCK, GenG vs T1, de la opinión de Faker sobre el metajuego del LoL, de cómo cambiaría Caps la offseason de LoL y viene Sh4rin a hablar de los fighting games. APÓYANOS AQUÍ https://www.patreon.com/Esportmaniacos https://www.twitch.tv/esportmaniacos 🔁Nuestras redes🔁 https://twitter.com/Esportmaniacos https://www.tiktok.com/@esportmaniacos 💙Referido de AMAZON: https://amzn.to/36cVx3g 00:00:00 - 00:15:00 - Intro 00:15:00 - 00:33:30 - Faker y el meta del LoL 00:33:30 - 00:48:00 - Caps y la offseason 00:48:00 - 00:58:20 - T1 vs GenG 00:58:20 - 01:31:00 - Vuelven MKOI y G2 01:31:00 - 01:45:05 - Viene Sh4rin 01:45:05 - 02:00:03 - Previa SLD #koi #mkoi #g2 #lec #lol #faker #t1

Thorin and Yamato discuss Faker's spot on T1, T1's potential for more big wins following their victory over GenG in the LCK, the start of LTA Summer, MKOI's chances to stay at the top of LEC with its new Summer format, the latest from the LPL, and more! Protect your online privacy TODAY by visiting https://ExpressVPN.com/summoning and you can get up to four extra months FREE.   Go to https://www.buyraycon.com/lfn TODAY to get up to 20% off the fan-favorite Everyday Earbuds Classic! Control Body Odor ANYWHERE with Mando and get 20% off + free shipping with promo code SUMMONING at shopmando.com!

In this episode of The Four Horsemen, Richard Lewis, Thorin, and MonteCristo dive into the latest controversies in the esports world. They dissect Cadrel's controversial decision to co-stream the EWC for Saudi Arabia amidst ethical concerns and the backlash from fans. The trio also breaks down T1's public apology and the fallout from Joe Marsh's comments about player contracts, examining the inner workings of Korean corporate culture in esports. They also discuss Travis Gafford stepping away from LoL esports content. Tune in for an unfiltered discussion on the moral complexities and insider stories shaping the esports landscape. Improve your game with a cutting-edge Wooting keyboard and get a free uWu now! Go to https://wooting.io/ and add any keyboard and uWu to your cart with code HORSEMEN and get your uWu for free! For a limited time, our listeners get 10% off at Ridge by using code HORSEMAN at checkout. Just head to https://Ridge.com and use code HORSEMAN Get the ultimate immersive gaming experience with Turtle Beach today! For a limited time only, head to https://TurtleBeach.com and use Code HORSEMAN for 10% off your entire order.

IWDominate, Jamada, and dGon debate which LoL esports team is the worst ever in history, GenG's place as one of the best League of Legends teams ever, Faker re-signing with T1, roster moves made before the Summer season, and more! ​Improve your game with a cutting-edge Wooting keyboard and get a free uWu now! Simply add any keyboard and uWu to your cart with code SPIKE and get your uWu for free! Go to https://link.wooting.io/powerspike Get 50% off FACTOR meals at https://www.factormeals.com/powerspike50off with code powerspike50off. High-quality, never-frozen meals delivered to your home!

Thorin and Yamato discuss Faker's spot on T1, T1's potential for more big wins following their victory over GenG in the LCK, the start of LTA Summer, MKOI's chances to stay at the top of LEC with its new Summer format, the latest from the LPL, and more! Sign up for your $1 per month trial and start selling today at https://shopify.com/summoning Upgrade your wallet today! Get 10% Off Ridge with code SI at https://www.Ridge.com/SI Control Body Odor ANYWHERE with Mando and get 20% off + free shipping with promo code SUMMONING at shopmando.com! Get 50% off FACTOR meals at https://www.factormeals.com/lfn50off with code lfn50off. High-quality, never-frozen meals delivered to your home!

Offensive words, AI weapons, T1.Songs of the Week:ADS: Clipse - E.B.I.T.D.A.WAX: ⁠⁠⁠Teddybears + Iggy Pop - PunkrockerPROD. KEITH: Blaire + TJ Brown - Forever⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Support Us on ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Ko-fi⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.

Thorin and Yamato discuss GenG and their victory at the Esports World Cup, the drama around Caedrel co-streaming EWC, AL's strong 2nd place finish, T1 and HLE's forms at the event, the first week of LPL Summer, NAVI's roster heading into LEC Summer, and more! Get the ultimate immersive gaming experience with Turtle Beach today! For a limited time only, head to https://TurtleBeach.com and use Code SUMMONING for 10% off your entire order. Protect your online privacy TODAY by visiting https://ExpressVPN.com/summoning and you can get up to four extra months FREE.   Go to https://www.buyraycon.com/lfn TODAY to get up to 20% off the fan-favorite Everyday Earbuds Classic! Get up to 10 FREE meals and a free item for life at https://www.hellofresh.com/lfn10fm

In this episode, Sam Ashoo, MD and T.R. Eckler, MD discuss the July 2025 Emergency Medicine Practice article, Emergency Department Management of Status Epilepticus in Pediatric PatientsIntroductionWelcome and brief overview of the episodePromotion of EB Medicine's $1 for 7-day trial offerWhy Pediatric Status Epilepticus MattersSeizures make up ~1% of ED visits and ~3% of EMS callsHigh-risk and high-stakes condition requiring rapid actionStatus epilepticus now defined as ≥5 minutes of seizure activityILAE's T1 and T2 timelines help define when to treat and when damage beginsCommon CausesTop contributors:Fever/infectionStructural CNS abnormalitiesToxic ingestionsGenetic/metabolic disordersAdditional factors by age:Infants: febrile seizures, chromosomal issues, traumaSchool-age: autoimmune disordersAdolescents: eclampsia, hypertension, functional disordersAlways consider non-accidental traumaPrehospital CareIM midazolam is effective and recommended (RAMPART trial)Other options: intranasal, rectal, or IV benzodiazepinesEarly benzodiazepine administration improves outcomesImportance of airway support, glucose check, and EMS flexibilityParent-administered home meds (e.g. rectal diazepam) can be helpfulED Evaluation and Initial ManagementPrioritize ABCs: Airway, Breathing, Circulation, ConsciousnessUse end-tidal CO₂ to monitor ventilation if availablePoint-of-care glucose is essentialLabs: CMP, Mg, Phos, lactate, drug levels, pregnancy test (when indicated)Imaging: Head CT if concern for trauma, shunt malfunction, or focal signsCase examples highlight pitfalls and diagnostic delaysFirst-Line TreatmentBenzodiazepines remain the cornerstoneLorazepam preferred IV agent (0.1 mg/kg)Midazolam preferred if no IV access (IN, IM, or IO)Diazepam is also effective, especially rectallyBe mindful of respiratory depression and the need for airway controlSecond- and Third-Line TherapiesBased on ESETT trial:Levetiracetam, fosphenytoin, and valproate have similar efficacyLevetiracetam favored for safety and ease of useFosphenytoin may be avoided in trauma or toxicityValproate not recommended in mitochondrial diseasePhenobarbital reserved for refractory cases onlyRefractory Status EpilepticusDefinition: persistent seizures despite first- and second-line agentsRequires sedation and likely intubationInfusion options:Midazolam (preferred for flexibility)Propofol (short-term use only due to risk of infusion syndrome)Pentobarbital (rare, ICU-level care)Need for continuous EEG to assess seizure activitySpecial ScenariosNeonates:Watch for subtle signs (lip smacking, bicycling, tongue thrusting)Broad differential includes asphyxia, infection, metabolic errorsFebrile Status Epilepticus:Higher risk of CNS infections, especially if unvaccinatedConsider lumbar puncture if indicatedElectrolyte/Metabolic Triggers:Treat hypoglycemia, hyponatremia, and hypocalcemia directlyUse 3% saline or dextrose as appropriateDisposition and Discharge ConsiderationsMany children will require ICU-level careSome known epilepsy patients may go home if back to baselineEnsure rescue medications are up to date (rectal/intranasal benzos)Consider “clonazepam bridge” for short-term seizure preventionCollaborate with neurology for medication adjustment and follow-upFinal ThoughtsKeep treatment tables and dosing references accessibleEarly, aggressive treatment can prevent long-term harmEpisode closes with gratitude to article authors and a reminder to visit EBMedicine.netEmergency Medicine Residents, get your free subscription by writing resident@ebmedicine.net

Thorin and Yamato discuss the final matches of MSI 2025, the reasons why GenG are the best LoL esports team, T1 and Faker's performances at the event, what it will take for Western League of Legends teams to "bridge the gap" between them and Eastern teams, Maple un-retiring to return to PSG Talon, and more! Get the ultimate immersive gaming experience with Turtle Beach today! For a limited time only, head to https://TurtleBeach.com and use Code SUMMONING for 10% off your entire order. Upgrade your wallet today! Get 10% Off Ridge with code SI at https://www.Ridge.com/SI Control Body Odor ANYWHERE with Mando and get 20% off + free shipping with promo code SUMMONING at shopmando.com! Get up to 10 FREE meals and a free item for life at https://www.hellofresh.com/lfn10fm The Last Free Nation merch shop is open! Show off your fandom and support us and by purchasing  the high-quality items on our merch shop. Check our website for more info on shipping! https://go.lastfreenation.shop/summoningyt

IWDominate, Jamada, and dGon discuss GenG winning MSI 2025, the narratives surrounding Faker and runners-up T1, thoughts about Fearless Draft for Worlds and MSI, Dom's involvement with Cloud9, and more! ​Improve your game with a cutting-edge Wooting keyboard and get a free uWu now! Simply add any keyboard and uWu to your cart with code SPIKE and get your uWu for free! Go to https://link.wooting.io/powerspike Get 50% off FACTOR meals at https://www.factormeals.com/powerspike50off with code powerspike50off. High-quality, never-frozen meals delivered to your home! The Last Free Nation merch shop is open! Show off your fandom and support us and by purchasing  the high-quality items on our merch shop. Check our website for more info on shipping! https://go.lastfreenation.shop/powerspikeyt/

Welcome back to a brand new episode of The Dive Driven by Kia. Chronicler joins Azael and Kobe right after the insanity of the MSI Finals! They discuss the future of Fearless within the competitive scene, cover FlyQuest's intense series against BilliBilli Gaming, and reflect on their experience at MSI. Thank you to the fans who showed up for an epic MSI in Vancouver, and for all the listeners who tuned into these episodes!With MSI now concluded, get ready as the LTA North returns July 26th with FlyQuest taking on Disguised at 1PM PT/4PM ET, followed by Cloud9 vs Lyon.Timestamps:0:00 Intro and T1 vs Gen.G Finals Recap 21:46 Doran was not the problem27:29 FlyQuest vs BiliBili Gaming42:52 MSI Memories & Fan Appreciation

Max walks into a 737 cockpit guarded by a five-inch hula girl and promptly invents the “Shakira Scale” for bumps in flight . Listener mailbag hits everything from the best starter credit card for flight instructors to whether a degree really matters and if paying $5 K for ATP-CTP is smart when you're 49 and eyeing the next hiring wave . In Flight Advice, a military helo pilot with only ten working years left asks whether to chase a major or ride the fractional lifestyle . Plus: back-country flower bombs, 37-hour B-2 runs, and a polite plea to stop yelling at the intro. Show Notes 0:00 Intro 10:08 Reginald Sage Returns: EASA Single Pilot 11:24 Max's Musings 15:38 B-2 Bomber 19:33 Reviews and Comments 24:05 Mailbag 37:46 Fight Advice Be sure to subscribe to 21Five's Youtube Channel to see our luggage review videos! Connect with us on LinkedIn Our sponsors: Move your airplane without breaking your back or the bank! Max said the Amigo AeroTow's affordable T1 tug has 'changed his hangar life'. Learn more about AeroTow's family of aviation tugs and see why its earning rave reviews from top 40 aviation podcast hosts around the globe. Use code "21five" at checkout for $100 off any AeroTow product! -- Harvey Watt, offers the only true Loss of Medical License Insurance available to individuals and small groups. Because Harvey Watt manages most airlines' plans, they can assist you in identifying the right coverage to supplement your airline's plan. Many buy coverage to supplement the loss of retirement benefits while grounded. Visit harveywatt.com to learn more! -- Advanced Aircrew Academy enables flight operations to fulfill their training needs in the most efficient and affordable way—anywhere, at any time. We do this by providing high-quality professional pilot, flight attendant, flight coordinator, maintenance, and line service training modules delivered via the web using a world-class online aviation training system. Visit aircrewacademy.com to learn more! -- Tim Pope is a CERTIFIED FINANCIAL PLANNER™ and a pilot. His financial planning practice provides services to aviation professionals and aviation 401k plans. Tim helps clients pursue their financial goals by defining them, organizing & optimizing resources, planning, implementing, and monitoring their financial plan. Visit https://link.21fivepodcast.com/timothy-pope to learn more. Check out Tim's podcast: The Pilot's Portfolio podcast -- VSL ACE Guide Version – Your All-in-One Pilot Training Resource Stay ahead in your aviation journey with the VSL ACE Guide, meticulously crafted to provide everything you need for pilot training and certification. This guide includes the most up-to-date Airman Certification Standards (ACS) and Practical Test Standards (PTS) for Private Pilot, Instrument, Commercial, Airline Transport Pilot (ATP), Certified Flight Instructor (CFI), and Instrument Instructor (CFII) ratings. 21Five listeners get a discount on the guide, click here to learn more! VAERUS MEANS RIGHT, TRUE, AND REAL.Buy or sell an aircraft the right way, using a true partner, to make your dream of flight real. Connect with Brooks at Vaerus Jet Sales | Learn more about the DC-3 Referral Program -- The 21.5 Podcast is supported by our friends at ProPilotWorld.com - The Premier Information & Networking Resource for Professional Pilots -- Do you have feedback, suggestions, or a great aviation story to share? Email us info@21fivepodcast.com Check out our Instagram feed @21FivePodcast for more great content and to see our collection of aviation license plates. The statements made in this show are our own opinions and do not reflect, nor were they under any direction of any of our employers.

Thorin and Yamato give thoughts and analysis on MSI 2025, preview the upcoming banger matchup between Faker and T1 vs Chovy and GenG, discuss CFO's strong performances and upset potential vs AL, assess FlyQuest's chances to get a win vs BLG, give reasoning as to why the LEC squads didn't perform as strongly at MSI this year, and more! Upgrade your wallet today! Get 10% Off Ridge with code SI at https://www.Ridge.com/SI Control Body Odor ANYWHERE with Mando and get 20% off + free shipping with promo code SUMMONING at shopmando.com! Go to https://www.buyraycon.com/lfn TODAY to get up to 15% off their best-selling Everyday Earbuds! Last Free Nation merchandise is here! To celebrate, we're giving away several items from our merch shop. To be eligible, all you need to do is head to the Last Free Nation Discord server and follow the instructions in the "merch giveaway" channel. Entries will close next Sunday (the 13th), winners will be announced next week. Thank you for supporting our network! Last Free Nation Discord server: https://discord.gg/zeWYq4JhEU Last Free Nation merch shop: https://lastfreenation.shop

Welcome back to a brand new episode of The Dive, Driven by Kia. MSI 2025 is already delivering some exciting games, and the crew is here to break it all down. They take a look at standout moments from every region, including an unforgettable showdown between NA and EU, an impressive showing from the LCP, and absolute bangers featuring LCK and LPL powerhouses. The team also looks ahead to Week 2's high stakes matchups, spicy storylines, and discusses which teams are heating up and which ones might be in trouble.Who's looking the strongest? Who needs to bounce back? Let us know what you think in the comments below!MSI continues July 7 at 5PM PT/8PM ET. Timestamps:0:00 - Intro & Farewell to Europe3:23 - Champion Win rates at MSI9:31 - FlyQuest vs G2 Esports Recap26:05 - Gen.G vs Anyone's Legend Recap30:37 - The Evolution of Champion Strategies44:00 - Movistar KOI vs CTBC Flying Oyster Recap46:46 - T1 vs BLG Recap1:08:59 - CTBC Flying Oyster's Impressive Showing 1:17:43 - CTBC Flying Oysters vs Anyone's Legend Preview1:29:57 - FlyQuest vs BiliBili Gaming Preview1:37:42 - Gen.G vs T1 Preview

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Thorin and Yamato discuss the results of the MSI 2025 Play-Ins, Poby leaving T1 for Fnatic, preview the MSI matches between GenG and G2, MKOI and BLG, AL and FlyQuest, plus CFO and T1, make predictions for the rest of the event, and more! Control Body Odor ANYWHERE with Mando and get 20% off + free shipping with promo code SUMMONING at shopmando.com! Shop the Into the AM Fourth of July Day Sale with up to 60% OFF until July 7! Save an additional 10% by using our link: https://intotheam.com/LFN Get up to 10 FREE meals and a free item for life at https://www.hellofresh.com/lfn10fm Go to https://www.buyraycon.com/lfn TODAY to get up to 15% off their best-selling Everyday Earbuds! The Last Free Nation merch shop is open! Show off your fandom and support us and by purchasing  the high-quality items on our merch shop. Check our website for more info on shipping! https://lastfreenation.shop

WWII & Vietnam combat pilot Col. Richard “Dick” Bushong takes us from 155-knot B-17 climbs to Mach 2.1 in the F-4, describing 28 hairy missions, dead-reckoning nav, and sheet-metal patch art. He's 102, still volunteers every Thursday at Tucson's 390th Memorial Museum, and wrote My Wars to capture the stories. Grab a coffee, tighten your formation, and hear a masterclass in staying alive—plus the morale-crushing day HQ “prorated” his tour. Four engines, two out, no brakes? No problem. Learn more about the 390th Memorial Museum in Tucson, AZ Check out Col. Bushong's book My Wars Show Notes 0:00 Intro 6:00 Getting Into Aviation 16:50 390th Bomb Group 28:53 Missions and Formations 39:10 Logistics 44:33 Closest Call   Be sure to subscribe to 21Five's Youtube Channel to see our luggage review videos! Connect with us on LinkedIn Our sponsors: Move your airplane without breaking your back or the bank! Max said the Amigo AeroTow's affordable T1 tug has 'changed his hangar life'. Learn more about AeroTow's family of aviation tugs and see why its earning rave reviews from top 40 aviation podcast hosts around the globe. Use code "21five" at checkout for $100 off any AeroTow product! -- Harvey Watt, offers the only true Loss of Medical License Insurance available to individuals and small groups. Because Harvey Watt manages most airlines' plans, they can assist you in identifying the right coverage to supplement your airline's plan. Many buy coverage to supplement the loss of retirement benefits while grounded. Visit harveywatt.com to learn more! -- Advanced Aircrew Academy enables flight operations to fulfill their training needs in the most efficient and affordable way—anywhere, at any time. We do this by providing high-quality professional pilot, flight attendant, flight coordinator, maintenance, and line service training modules delivered via the web using a world-class online aviation training system. Visit aircrewacademy.com to learn more! -- Tim Pope is a CERTIFIED FINANCIAL PLANNER™ and a pilot. His financial planning practice provides services to aviation professionals and aviation 401k plans. Tim helps clients pursue their financial goals by defining them, organizing & optimizing resources, planning, implementing, and monitoring their financial plan. Visit https://link.21fivepodcast.com/timothy-pope to learn more. Check out Tim's podcast: The Pilot's Portfolio podcast -- VAERUS MEANS RIGHT, TRUE, AND REAL.Buy or sell an aircraft the right way, using a true partner, to make your dream of flight real. Connect with Brooks at Vaerus Jet Sales | Learn more about the DC-3 Referral Program -- The 21.5 Podcast is supported by our friends at ProPilotWorld.com - The Premier Information & Networking Resource for Professional Pilots -- Do you have feedback, suggestions, or a great aviation story to share? Email us info@21fivepodcast.com Check out our Instagram feed @21FivePodcast for more great content and to see our collection of aviation license plates. The statements made in this show are our own opinions and do not reflect, nor were they under any direction of any of our employers.

Welcome back to The Dive Driven by Kia! Hot off the intense last day of MSI Play-Ins, Azael, Kobe, & Meteos break down all the action from the first 3 days and share how their MSI experience has been so far. With the Bracket Stage just around the corner, the crew look ahead at the exciting matchups, key players, and storylines to keep an eye on.The MSI Bracket Stage begins July 1st at 5:00pm PT/8:00pm ET as Gen.G takes on G2 Esports.Timestamps:0:00 - Intro & Initial Play-Ins Thoughts3:25 - FURIA MSI Performance8:30 - GAM vs G228:10 - BiliBili Gaming Domination32:06 - Bracket Stage Matchup Previews - G2 vs Gen.G 37:47 - FlyQuest vs Anyone's Legend45:59 - Movistar KOI vs BiliBili Gaming52:00 - CTBC Flying Oysters vs T1

Dylan and Max are recording from hotel rooms across the country and catching up after some time off. They kick things off with a deep dive into aviation YouTube, comparing backcountry flying with ferrying retired Airbuses from Asia. In the mailbag, they respond to listeners with questions about juggling a corporate flying gig while working for a major airline, updates from a newly minted high school grad CFI, and a debate on whether you need to report vacating altitudes during "descend via" clearances. Flight Advice wraps the episode with tips for a low-time pilot who just landed a chief pilot role flying a TBM. Sunscreen recs: Sky and Sol | Freaks of Nature Caspian Sea Monster Ekranoplan Flight Video Homework: Watch The Rehearsal: Season 2   Show Notes 0:00 Intro 4:41 Max's Musings: LRD, Reggie, YouTube & TV 23:20 Reviews 24:43 Mailbag: Nate Update & More 47:21 Flight Advice: Great Opportunity, Low Experience   Be sure to subscribe to 21Five's Youtube Channel to see our luggage review videos! Connect with us on LinkedIn Our sponsors: Move your airplane without breaking your back or the bank! Max said the Amigo AeroTow's affordable T1 tug has 'changed his hangar life'. Learn more about AeroTow's family of aviation tugs and see why its earning rave reviews from top 40 aviation podcast hosts around the globe. Use code "21five" at checkout for $100 off any AeroTow product! -- Harvey Watt, offers the only true Loss of Medical License Insurance available to individuals and small groups. Because Harvey Watt manages most airlines' plans, they can assist you in identifying the right coverage to supplement your airline's plan. Many buy coverage to supplement the loss of retirement benefits while grounded. Visit harveywatt.com to learn more! -- Advanced Aircrew Academy enables flight operations to fulfill their training needs in the most efficient and affordable way—anywhere, at any time. We do this by providing high-quality professional pilot, flight attendant, flight coordinator, maintenance, and line service training modules delivered via the web using a world-class online aviation training system. Visit aircrewacademy.com to learn more! -- Tim Pope is a CERTIFIED FINANCIAL PLANNER™ and a pilot. His financial planning practice provides services to aviation professionals and aviation 401k plans. Tim helps clients pursue their financial goals by defining them, organizing & optimizing resources, planning, implementing, and monitoring their financial plan. Visit https://link.21fivepodcast.com/timothy-pope to learn more. Check out Tim's podcast: The Pilot's Portfolio podcast -- VAERUS MEANS RIGHT, TRUE, AND REAL.Buy or sell an aircraft the right way, using a true partner, to make your dream of flight real. Connect with Brooks at Vaerus Jet Sales | Learn more about the DC-3 Referral Program -- The 21.5 Podcast is supported by our friends at ProPilotWorld.com - The Premier Information & Networking Resource for Professional Pilots -- Do you have feedback, suggestions, or a great aviation story to share? Email us info@21fivepodcast.com Check out our Instagram feed @21FivePodcast for more great content and to see our collection of aviation license plates. The statements made in this show are our own opinions and do not reflect, nor were they under any direction of any of our employers.

Today we take a look at the inaugural Rockford 70.3. We get into the course, race strategies, and how to handle what looks to be a hot day. We talk about the city, wetsuit or not, river flow and a pre-race HR test. We also get into how to stay as cool as possible all day with tips for pre-race, T1, the bike, T2 and the run. This will be a game of being smart and patient and we'll give you thoughts on how to do just that. Topics: Rockford Downtown - Mike's old stomping grounds Will this race jumpstart the city? Dealing with the heat Wetsuit or not? Why it's too late for heat prep Don't drain your body this week Stay out of the heat River flow Pre-race HR test A lot of first timers Pop a gel at the end of the swim Cold water after the swim Too eager to push a higher zone Once you overheat, there's no turning back Wind mind games It's all about being smart and patient Carrying nutrition on the run? Carrying ice Zip lock tricks When you're dehydrated and full Plain water on board? Body glide Wearing hats Your swim route (based on the map) The finish line vibe     mike@c26triathlon.com robbie@c26triathlon.com

In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with Kristen Chase, General Manager of Nutrire, a trailblazing new brand changing the way we think about hair care. Rather than focusing only on the strands, Nutrire turns attention to the scalp—the true foundation of healthy hair—and introduces a science-backed, salon-informed approach to long-term hair wellness.Kristen shares her transition from legacy beauty brands to co-creating Nutrire in collaboration with the experts at Tricoci Salon & Spa. The result? A dual-diagnosis system that looks at both scalp type and hair type, bringing dermatological precision into the haircare space.Listeners will get a first look at Nutrire's hero ingredients and technologies—including Complex8™, a natural DHT-blocking blend, and the T1 and T2 Serums, developed with clinically validated, trichologist-approved formulas. The line also introduces a fresh way to shop haircare—by identifying your scalp type the same way you'd assess skin.From personalized routines to the future of hair loss solutions, this episode explores how Nutrire is merging skin science and hair expertise to transform everyday routines into targeted treatment plans.Whether you're dealing with thinning, dryness, or simply curious about a more intelligent way to care for your scalp, this conversation opens the door to the next era in hair wellness.Listen now to discover how Nutrire is making scalp care the new skincare—and why it's time to rethink your entire hair routine.CHAPTERS:(0:00) Introduction to Nutrire and Scalp Health(1:05) Kristen's Background in Beauty Brands and Transition to Nutrire(2:07) Nutrire's Vision and Focus on Scalp Health(4:14) The Importance of Scalp Care in Hair Health(7:08) Product Range and Focus on Simplicity(9:02) Formulating Nutrire's Day and Night Serums(10:31) Addressing Scalp Type and Skin Type for Effective Hair Care(13:12) The Importance of Clinical Proof and Gentle Efficacy(27:13) Future Innovations and Nutrire's Ongoing MissionTo learn more about Nutrire, visit their website and social media.Don't forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform. Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf! Hosted on Acast. See acast.com/privacy for more information.