Podcasts about professor rose anne kenny

Biohacking is the latest thing people are implementing to reduce their biological age, but can our biological age truly be reduced, and are trackers and watches accurate at determining a person's biological age?Joining Kieran to discuss is Professor Rose Anne Kenny, Head of the aging research program at Trinity.

Just like Danny Glover in Lethal Weapon, as we get older, we often discount our ability or our suitability to do certain things on account of our age.But, does saying “I'm too old for this or that” actually accelerate the ageing process?Professor Rose Anne Kenny is the Chair of Medical Gerontology at Trinity College Dublin, and joins Seán to discuss.

Just like Danny Glover in Lethal Weapon, as we get older, we often discount our ability or our suitability to do certain things on account of our age.But, does saying “I'm too old for this or that” actually accelerate the ageing process?Professor Rose Anne Kenny is the Chair of Medical Gerontology at Trinity College Dublin, and joins Seán to discuss.

Last year, a study found that a third of Americans aged between 50 and 80 feel lonely. I'm sure most of us can relate to this feeling, and understand how a lack of social connection can take a serious toll on our mental health. But, is loneliness affecting more than just our minds? Does it also impact our physical health and how well we age? In this episode, Professor Rose Anne Kenny joined me to answer these questions and discover ways that we can foster meaningful relationships. She starts by telling us about her groundbreaking study into ageing in Ireland. 

Are you part of the ‘Sandwich Generation'?This refers to middle-aged adults who are caring for both elderly parents and their own children.Nowadays, with older generations living longer and young people staying at the family home later in life – more and more people may consider themselves part of the Sandwich Generation. Does this sound like your experience?Andrea is joined by The Midlife Coach Alana Kirk and Professor Rose Anne Kenny from Trinity College Dublin to discuss.

Today's guest brings valuable insights about what we can do to make sure we age healthily and happily. Feel Better Live More Bitesize is my weekly podcast for your mind, body, and heart. Each week I'll be featuring inspirational stories and practical tips from some of my former guests.   Today's clip is from episode 400 of the podcast with Professor Rose Anne Kenny. Professor Kenny is a medical gerontologist and Regius Professor of Physic and Chair of Medical Gerontology at Trinity College Dublin. She's the Founding Principal Investigator of Ireland's largest population study of ageing (TILDA) and the author of the international bestseller Age Proof: The New Science of Living a Longer and Healthier Life. In our conversation, she revealed that while 20% of ageing is genetic and can't be changed, 80% is epigenetic. In other words, we have the power to influence how quickly or how slowly we age. In this clip, she shares some of the simple, practical things we can all do to embrace the 80% that's within our control. Thanks to our sponsor https://www.drinkag1.com/livemore Support the podcast and enjoy Ad-Free episodes. Try FREE for 7 days on Apple Podcasts https://apple.co/feelbetterlivemore. For other podcast platforms go to https://fblm.supercast.com. Show notes and the full podcast are available at https://drchatterjee.com/400 DISCLAIMER: The content in the podcast and on this webpage is not intended to constitute or be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or other qualified health care provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website.

Anton was joined by Professor Rose Anne Kenny, Principal Investigator of TILDA, to discuss their new designation as a WHO Collaborating Centre and how Ireland will play a leading role in ageing research worldwide.

Professor Rose Anne Kenny, Head of the Ageing Research Programme, Trinity College Dublin / Seamus Boland, CEO Irish Rural Link / Anne Dempsey, Communications manager for Seniorline

Scientists have discovered that aging isn't as gradual as we once thought. Instead, it happens in two dramatic bursts first at 44 and then again at 60. These findings could shed light on why certain health problems often surge at these specific ages. We discuss with Professor Rose Anne Kenny, Head of the ageing research program at Trinity College.

Scientists have discovered that aging isn't as gradual as we once thought. Instead, it happens in two dramatic bursts first at 44 and then again at 60. These findings could shed light on why certain health problems often surge at these specific ages. We discuss with Professor Rose Anne Kenny, Head of the ageing research program at Trinity College.

Professor Rose Anne Kenny, Head of the Ageing Research Programme at Trinity College discusses the importance of taking control of the ageing process by looking after your fitness and health. Listeners share their own approach whether that be Botox or ageing naturally.

Regius Professor Rose Anne Kenny is the founding Principal Investigator of The Irish Longitudinal Study on Ageing (TILDA). Professor Kenny tells Sean how she got into Medical Gerontology, and reveals some interesting findings from the study, including the need to prioritise social engagement as loneliness has become much more common in Ireland.

Professor Rose Anne Kenny joined Pat this morning on the show to talk about her memories of the late philanthropist Chuck Feeney. We hear about the new ‘Feeney Way' and the significant benefits of volunteering.

This episode is brought to you by Birch Living, LMNT, and Sweetgreen.As the New Year starts, we may be exposed to the new trends marketed to help us kickstart our health. But we know that consistently doubling down on the fundamentals is the key to longevity. Today on The Dhru Purohit Podcast, Dhru sits down with Professor Rose Anne Kenny to discuss the science of aging and the key factors that can help us age well. Professor Kenny shares her decades of research on aging and tests that can help us identify if we are aging optimally. She also discusses the importance of consistently focusing on resistance training, diet, exposure to nature, and community.Professor Kenny reminds us that we are not all doomed and that 80% of how we age is based on the habits and fundamentals we engage in daily. If you want motivation and inspiration to hone in on simple changes we know are tried and true, this episode is for you. Rose Anne Kenny holds the chair of medical gerontology at Trinity College Dublin and St. James's Hospital and is director of Mercer's Institute for Successful Aging. Before her present appointment, Kenny held the chair of cardiovascular research at the University of Newcastle, where she was head of academic and clinical departments of medical gerontology for 12 years. She has published extensively on cardiovascular risk factors for falls and cognitive decline in aging. Her recently published book “Age Proof – The New Science of Living a Longer and Healthier Life” was shortlisted for the Royal Society Science Book Prize 2022. In this episode, Dhru and Professor Kenny dive into (audio version / Apple Subscriber version):The importance of quality social relationships for longevity (2:55 / 2:55) The misconceptions about aging and going back to the fundamentals (9:37 / 6:33)How do you know if you are aging well (19:33 / 16:33)Focusing on blood pressure testing and optimal ranges (26:17 / 21:47)Lipid panel and the critical tests for metabolic health (42:57 / 38:20)Grip strength and measuring V02 max as factors of aging (48:28 / 43:52)Professor Kenny's longitudinal studies and the importance of nature, approaching life with curiosity, and healing childhood traumas (56:50 / 52:25)The importance of hormesis through cold therapy (1:06:42 / 1:02:08)80% of aging is epigenetics (1:10:56 / 1:06:20)Roseto effect and the impact of close-knit community (1:15:04 / 1:10:30)Four factors that accelerated aging (1:23:14 / 1:18:11)The fears around aging (1:27:11 / 1:22:35)For more on Professor Kenny follow her on Twitter @RoseAnnekenny1 To get 20% off your Birch Living mattress plus two free eco-rest pillows, head over to birchliving.com/dhru today.Right now, LMNT is offering my listeners a free sample pack with any purchase. Head over to DrinkLMNT.com/dhru today.Find out more about Sweetgreen and their newest protein plates at www.sweetgreen.com. New Users of the sweet green app can use the code "Dhru5" for $5 off. Hosted on Acast. See acast.com/privacy for more information.

Professor Rose Anne Kenny, Head of the department of Medical Gerontology at TCD

Longevity is a hot topic these days. We're obsessed with anti-ageing as if getting older should be avoided or even reversed at all costs! Of course, we can't do that and I'm not sure we'd really want to. But today's guest brings valuable insights about what we can do, to make sure we age healthily and happily.Professor Rose Anne Kenny is a medical gerontologist, Regius Professor of Physic and Chair of Medical Gerontology at Trinity College Dublin. She's the Founding Principal Investigator of Ireland's largest population study of ageing (TILDA) and the author of the international bestseller Age Proof: The New Science of Living a Longer and Healthier Life.In today's conversation, Professor Kenny reveals that while 20 percent of ageing is genetic and can't be changed, 80 percent is epigenetic – in other words, we have the power to influence how quickly or how slowly we age.Her number one recommendation is to have good quality friendships and relationships throughout our lives. Then follow a healthy diet, plenty of exercise, and reduce stress. Nothing too surprising, perhaps. But what might surprise you is just how far reaching the effects of these relatively simple measures can be – and how much what you do in your 20s can impact your 80s.We talk about how to avoid metabolic syndrome and why it's important to know key biological markers throughout life. We discuss the benefits of community, family, volunteering and inter-generational friendships, and the undercurrent of ageism that prevails in society.Loneliness increased threefold during the pandemic, according to the TILDA study, and it's left some people feeling afraid to reconnect. Yet isolation is known to cause inflammation, suppress immunity and speed ageing.Professor Kenny believes we should flip convenience on its head when it comes to exercise. Instead of taking the easy option which means moving less, we should look at the ‘harder' options, such as taking the stairs or carrying heavy bags, as convenient ways to build activity and strength training into our lives. She also shares excellent advice on sex and intimacy, sleeping better, laughing more, and finding purpose all around you.This is a wonderful and practical conversation that is going to give you a variety of simple ways to play the long game when it comes to ageing. And the empowering message is that it's never too early or too late to start.Support the podcast and enjoy Ad-Free episodes. Try FREE for 7 days on Apple Podcasts https://apple.co/feelbetterlivemore. For other podcast platforms go to https://fblm.supercast.com.Thanks to our sponsors:https://hunterandgatherfoods.com/livemorehttps://drinkag1.com/livemorehttps://naturalmat.co.uk/livemoreShow notes https://drchatterjee.com/400DISCLAIMER: The content in the podcast is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your doctor or qualified healthcare provider. Never disregard professional medical advice or delay in seeking it because of something you have heard on the podcast or on my website. Hosted on Acast. See acast.com/privacy for more information.

This is the second of our special compilation episodes this summer; perfect for you to dip in and out of on your holidays, or to accompany you on any long journeys. This week we're focusing on a topic that comes up a lot on The Mid.Point: relationships. Be they romantic, familial, or purely platonic, they can often take on a new importance when navigating midlife. Like everything, relationships change and evolve over time and sometimes they no longer serve us by the midpoint, hence why many people find themselves navigating the end of a significant partnership or friendship at this time of life. However, scientific research suggests that there are anti-ageing properties bound up in social interactions and a sense of community, so it's vitally important that we keep making friendships throughout our lives. But it can be hard to put yourself out there, especially when it comes to dating. These are all aspects that our wonderful guests - Elizabeth Day, Phil Neville, Rob Rinder, Jane Fallon, Kelly Cates, Kirsty Gallacher, Kenny Logan, sobriety advocate Matt Pink, and Professor Rose Anne Kenny – all touch on in this week's episode. Hosted on Acast. See acast.com/privacy for more information.

Driving Life with Conor Faughnan Ep 42: Professor Rose Anne Kenny of the TILDA study, Ireland's world class Longitudinal Study on Aging. She tells Conor how it works, what its teaching us about life and health as we live longer and hopefully happier.

Topics covered : Best foods to eat and when to eat them, genetics, blue zones, impact of Covid, exercise, sleep, sex, connections, engagement, laughter.Professor Rose Anne Kenny has 35 years of experience at the forefront of ageing medicine and in this conversation she shares some of the proven adjustments we can all make regardless of our age, to live longer and happier lives.Her book is ‘Age Proof: The New Science of Living a Longer and Healthier Life' and it's a fascinating read.If you enjoyed this episode, please consider following the pod wherever you listen. You can now rate it on Spotify and leave a little comment on Apple too.Thanks a million! Hosted on Acast. See acast.com/privacy for more information.

This week, Gabby takes a deep dive into the biology of ageing with Professor Rose Anne Kenny. Professor Kenny is a physician, researcher, and the founding principal investigator of The Irish LongituDinal study on Ageing. Rose Anne is also a best-selling author, and Gabby has read her book - Age Proof: The New Science of Living a Longer and Healthier Life - cover to cover! They discuss key topics from her research, including what epigenetics are and how we can influence them and our biological ageing, the commonalities that people living in the so-called Blue Zones have and what this teaches us about how to live long and healthy lives, and how research shows it's never too late to make a difference to how you're ageing on the inside. Professor Kenny also answers your questions on everything from supplements and exercise, to how much we should eat as we get older. Hosted on Acast. See acast.com/privacy for more information.

Subscribe to hear all of our new episodes free and first and head over to Twitter where you'll find us - @WTSpod  This week we're learning about the science of ageing and some simple things we can all do to help ourselves be younger, and healthier, for longer.  Rose Anne Kenny is Professor of Medical Gerontology, at Trinity College Dublin. Professor Kenny was appointed in 2005, to Trinity College and St. James's Hospital, as Head of the Academic Department of Medical Gerontology and holds the Chair of Medical Gerontology. Rose Anne is the founding Principal Investigator of The Irish Longitudinal Study on Ageing TILDA : www.tilda.ie), Ireland's flagship research project in ageing - where she leads a team of multidisciplinary researchers focusing on psychology, nursing, medicine, physiotherapy, economics, bio-engineering, social sciences and health economics as aspects of the ageing process in Ireland.  

Professor Rose Anne Kenny reinforced the keys to aging well following on from the Super Agers documentary on RTE last evening. It's Pancake heaven at Rocksalt Cafe in Blackrock all day today! Dom McGroddy spoke touchingly about his wife Lily who is this year's ambassador for the national # Drink Tea for MND campaign. Sinead Kelly answered listeners veterinary questions, out of adversity Barbara Keogh established her own successful cleaning business and Gerry really enjoyed his Pancake made from scratch by Louise... Hosted on Acast. See acast.com/privacy for more information.

Ahead of the documentary ‘Mary Kennedy: Fad Saoil' on TG4 next week looking at ways of staying healthy and ageing well, chat with broadcaster Mary Kennedy and Professor Rose Anne Kenny, who is founder of the TILDA study

A new study published in the British Medical Journal suggests monkey pox might be passed from person to person before symptoms show. Esther Freeman, Assistant Professor of Dermatology at Harvard Medical School and Director of Global Health Dermatology at Massachusetts General Hospital, has been following the current wave of transmission and gives us her analysis of this latest finding, The COP 27 climate summit kicks off next week. To discuss some of the issues we are joined by Simon Lewis, Professor of global change science at University College London and Swenja Surminski, Professor in Practice at the Grantham Research Institute and a member of the UK's Committee on Climate Change. Mark Miodownik, the UCL Professor of Materials & Society, tell us the results of his citizen science project looking at composting plastics. And from the short list for the Royal Society Insight Investment Science Book Prize, we hear from Professor Rose Anne Kenny on her book Age Proof: The New Science of Living a Longer and Healthier Life.

John Sweeney, Climate Change Scientist and Emeritus Professor at Maynooth University, Professor Rose Anne Kenny, Head of the department of Medical Gerontology at Trinity College Dublin, Dr Laura Lenihan, GP in Galway

Michael Sullivan chats with Professor Rose Anne Kenny, Principal Investigator of TILDA, about the Irish longitudinal study on ageing recruiting new participants. Visit:  www.tilda.tcd.ie Participate:  Recruitment Publications

Professor Rose Anne Kenny, author of ‘'Age Proof'' and Head of the ageing research programme at Trinity College Dublin joined Sean to take a look at the science behind aging and what visual clues we use when trying to determine a persons age.     Listen and subscribe to Moncrieff on Apple Podcasts, Google Podcasts or Spotify.    Download, listen and subscribe on the Newstalk App.     You can also listen to Newstalk live on newstalk.com or on Alexa, by adding the Newstalk skill and asking: 'Alexa, play Newstalk'.

Professor Rose Anne Kenny, author of ‘'Age Proof'' and Head of the ageing research programme at Trinity College Dublin joined Sean to take a look at the science behind aging and what visual clues we use when trying to determine a persons age.     Listen and subscribe to Moncrieff on Apple Podcasts, Google Podcasts or Spotify.    Download, listen and subscribe on the Newstalk App.     You can also listen to Newstalk live on newstalk.com or on Alexa, by adding the Newstalk skill and asking: 'Alexa, play Newstalk'.

Topics covered : Best foods to eat and when to eat them, genetics, blue zones, impact of Covid, exercise, sleep, sex, connections, engagement, laughter.Professor Rose Anne Kenny has 35 years of experience at the forefront of ageing medicine and in this conversation she shares some of the proven adjustments we can all make regardless of our age, to live longer and happier lives.Her book is ‘Age Proof: The New Science of Living a Longer and Healthier Life' and it's a fascinating read.If you enjoyed this episode, please consider following the pod wherever you listen. You can now rate it on Spotify and leave a little comment on Apple too.Thanks a million! See acast.com/privacy for privacy and opt-out information.

Part two of our talk with Professor Rose Anne Kenny on aging well, what the research says will keep us happy and healthy well into old age.

This week on Real Health it's all about giving you the knowledge and the tools on how to not only live healthier, but longer too. While many of you will have read or been told what you need to do to live longer, it's as important to understand why making certain changes can have such a positive impact on longevity. From mindset to exercise and fasting, we are taking a look at the best changes you can make to your daily lives, with Professor Rose Anne Kenny. Rose Anne's new book Age Proof, The New Science of Living a Longer and Healthier Life looks at the latest research behind why we age and how a lot of it is within our control. While diet and exercise are important for staying healthy as you age, Rose Anne says it's also about your attitude to aging: “How you perceive yourself to aging, actually seems to influence your physical aging going forward [as well as] cognitive brain health.” In other words, you are as old as you feel. We also discuss how sitting for long periods of time can be toxic to our cells and what type of movement Rose Anne says is the best to keep you feeling young. For more episodes, tips and advice from the show just go to: independent.ie/podcasts/the-re…health-podcast.   And you can get in touch - I'm @KarlHenryPT on Instagram and realhealth@independent.ie.  Don't forget to rate, review and subscribe on Apple and Google Podcasts, Spotify, or wherever you get your podcasts from.  The Real Health podcast is in association with Laya Healthcare.

Rose Anne Kenny has accolades through the roof, and for good reason: she is a best selling-author, distinguished professor and successful medical gerontologist. She is also the founding Principal Investigator of Ireland's largest adult population study on the experience of ageing in Ireland - The Irish LongituDinal study on Ageing (TILDA), now in its 12th year of data collection. But perhaps her most important claim to fame is the positive impact her research is having on ageing populations, around Ireland and beyond. In this podcast, she gives us a glimpse of what we can actually do to improve our chances of aging in the most joyful and healthy way, and crucially why it is that these actions actually help us in the long run.

Professor Rose Anne Kenny

Professor Rose Anne Kenny, Head of the department of Medical Gerontology at TCD and Founding Principal Investigator of TILDA (The Irish Longitudinal Study on Ageing).

We all age. But why do some of us live longer than others? And why do we live twice as long today as our ancestors did 200 years ago? And what can the latest science teach us about living longer? Professor Rose Anne Kenny has 35 years of experience right at the top of ageing medicine and has written a book about Aging called - Age Proof. She spoke to Fran on Tipp Today this morning.

Coinciding with our "Call This Out" campaign around women's safety, the Irish Sun's Crime Editor Stephen Breen, reminded us about a forgotten murder and areas of life where we can all make a difference. Professor Rose Anne Kenny had plenty of advice on how to live a longer and healthier life. Clare Copas knows all about data protection, Pauline Ashwood is buzzing about the return of the Drogheda Classical Music concert series and we enjoyed more about Top Gun. See acast.com/privacy for privacy and opt-out information.

Gillian chats to Professor Rose Anne Kenny about her book 'Age Proof' and the science around living a longer healthier life See acast.com/privacy for privacy and opt-out information.

Higher omega-3 levels linked with lower risk of death during 16-year period The Fatty Acids and Outcomes Research Consortium, April 28 2021.    An analysis of prospective studies published on April 22, 2021 in Nature Communications uncovered a decreased risk of mortality during an average of 16 years among men and women who had higher red blood cell or plasma levels of omega-3 fatty acids.  The analysis was conducted by William S. Harris and The Fatty Acids and Outcomes Research Consortium (FORCE). Dr Harris is a codeveloper of the Omega-3 Index, which measures omega 3 levels in red blood cell membranes. The team examined 17 prospective studies that evaluated associations between the risk of death from all causes and levels of the omega-3 fatty acids alpha linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), and EPA plus DHA.  During the studies’ follow-up periods, 15,720 deaths occurred among a total of 42,466 men and women. Subjects whose EPA, DPA, DHA, and EPA plus DHA levels were among the top 10% of participants experienced a 9% to 13% reduction in mortality from all causes during follow-up compared to men and women whose levels were among the lowest 10%. When cause-specific mortality was examined, having EPA, DPA, DHA, or EPA plus DHA levels among the highest 10% was associated with a lower risk of cardiovascular mortality, cancer mortality and mortality from all other causes combined (with the exception of the association between DHA and reduced cancer mortality, which was not considered significant).  "Since all of these analyses were statistically adjusted for multiple personal and medical factors (i.e., age, sex, weight, smoking, diabetes, blood pressure, etc., plus blood omega-6 fatty acid levels), we believe that these are the strongest data published to date supporting the view that over the long-term, having higher blood omega-3 levels can help maintain better overall health," Dr Harris concluded.     New study shows tree nuts may play a role in both weight loss and weight maintenance   University of California at Los Angeles, May 4, 2021  In a randomized, controlled study* published online in the journal, Nutrients, researchers found that including mixed tree nuts in a weight management program resulted in significant weight loss and improved satiety. Researchers at UCLA compared 95 overweight/obese men and women (BMI 27.0-35.0 kg/m2) ages 30-68 years who consumed either 1.5 ounces of mixed tree nuts or a pretzel snack. Both snacks provided the same number of calories, as part of a hypocaloric weight loss diet (500 calories less than resting metabolic rate) over 12 weeks. This was followed by an isocaloric weight maintenance program for an additional 12 weeks.  Participants experienced significant weight loss (12 weeks: -1.6 kg and -1.9 kg and 24 weeks: -1.5 kg and -1.4 kg) in the tree nut and pretzel snack groups, respectively. Both groups also showed a significant decrease in BMI at 12 weeks, compared to baseline. However, satiety was significantly higher at the end of week 24 in the mixed tree nut group, and there was a trend toward greater weight maintenance compared to the pretzel group. Moreover, the dropout rate was significantly lower in the mixed tree nut group (16.4%) compared to the pretzel (35.9%) group. And, heart rate was decreased significantly, compared to baseline, in those consuming tree nuts, but not pretzels.  "Tree nuts (almonds, Brazil nuts, cashews, hazelnuts, macadamias, pecans, pine nuts, pistachios and walnuts) are a great source of protein, healthy fats and fiber," explained lead researcher, Zhaoping Li, MD, PhD, Professor of Medicine and Chief of the Division of Clinical Nutrition at UCLA. "This makes them so satiating and may be a major reason why we saw less weight gain in the tree nut group during weight maintenance, and a significantly lower dropout rate compared to the pretzel group."  Recent research has shown that more than 40 percent of Americans are overweight or obese.** During the past year many Americans have gained weight while sheltering in place, partly due to less exercise and more snacking. One study estimates a weight gain of 1.5 pounds per month.*** "We know most people get about 25% of their calories each day from snacks and a large proportion come from desserts, sugar-sweetened beverages, sweets and salty snacks," states Dr. Li. "By replacing just one of those snacks with 1.5 ounces of tree nuts may result in a positive impact on weight and overall health." According to Maureen Ternus, M.S., R.D.N, Executive Director of the International Tree Nut Council Nutrition Research & Education Foundation (INC NREF), "This latest study adds to a growing body of evidence showing that nut consumption may be a useful tool in weight management."     Green tea compound and coconut oil may help improve depression in multiple sclerosis patients Catholic University of Valencia (Spain), April 30. 2021   According to news reporting originating from Valencia, Spain, research stated, “Multiple sclerosis (MS) is pathogenically characterized by high oxidative stress and symptomatically by progressive muscle loss and increased body fat associated with the presence of depression. Epigallocatechin gallate (EGCG) (particularly present in green tea) and ketone bodies (in particular beta-hydroxybutyrate (BHB)), whose main source is coconut oil, have shown emotional benefits and body fat loss.” The news journalists obtained a quote from the research from Catholic University of Valencia: “The aim of this study was to assess the impact of EGCG and coconut oil on cortisol activity related to fat loss and depression in MS patients. The study involved 51 MS patients who were randomly divided into an intervention group or a control group. The intervention group received 800 mg of EGCG and 60 mL of coconut oil, which were included in their daily diet for four months. The control group received placebo and all patients followed an isocaloric diet. A blood sample was collected before and after the four-month period, and levels of cortisol, albumin and BHB were measured in serum. In addition, immediately before and after the intervention, anthropometric variables were measured: waist-to-hip ratio (WHR), body fat mass percentage, fat weight, total weight, and muscle mass percentage. Depression was assessed with the Beck Depression Inventory II (BDI-II). No significant changes were obtained in cortisol levels in any of the groups, and there was a significant increase in albumin in the blood of the intervention group only that could lead to a decrease in serum free cortisol. In addition, it was observed a significant decrease in levels of depression and abdominal fat.” According to the news reporters, the research concluded: “EGCG combined with coconut oil increase the concentration of albumin in blood and produce less depression in MS patients.”       Vulnerable older people at greater risk of depression and anxiety during pandemic   University of Manchester (UK), May 5, 2021 Older people who are clinically vulnerable to COVID-19 are at greater risk of deterioration in health and social well-being during the pandemic, according to a new study. The research, published in the Journal of Epidemiology and Community Health, found that older people were more likely to report worse health outcomes than those with no clinical vulnerabilities, including greater depression and anxiety and lower quality of life, even when taking into account pre-pandemic levels of health and social well-being. The findings highlight the need for policymakers to consider the mental and physical health consequences of the pandemic for those at higher risk from coronavirus, particularly for those asked to shield. Professor Debora Price from The University of Manchester and Dr. Giorgio Di Gessa from UCL compared data from 2020's English Longitudinal Study of Aging with data from the previous year. They analyzed responses from over 5000 people aged 52 and over in private households in England. The study revealed that during the pandemic, respondents classified as clinically vulnerable were more likely to report poor self-rated health, lower levels of physical activity, depression, anxiety, lower quality of life as well as loneliness and receipt of care, compared to those without clinical vulnerabilities. This was true within each age group. Among people in their 70s, the odds of being depressed and anxious for those clinically vulnerable were around 50% higher than for those without clinical vulnerabilities. Those in their 80s—regardless of clinical vulnerability—were much more likely to have unmet care needs and to have little contact with friends and family by text, email, or videocall. Although older adults' health and social well-being have been impacted by shielding, the researchers found that it was those who were clinically vulnerable and shielding who reported the most substantial rises in anxiety, depression, poor self-rated health and receipt of formal care, as well as decreases in well-being and physical activity. "Older people with underlying health conditions, even before the pandemic, faced challenges in terms of access to healthcare services and social contact," said Professor Debora Price. "They also experienced greater emotional distress, higher risk of loneliness and poorer quality of life than non-vulnerable individuals." "While policies focusing on shielding clinically vulnerable older people reduce rates of hospitalization and death from COVID-19, policymakers need to acknowledge that there may be adverse consequences of this measure and address the wider needs of these vulnerable groups," added Dr. Giorgio Di Gessa. "It's vital that policymakers are aware that when advised to stay at home, a host of health and social risks for this group, already poor, are likely to be exacerbated."   Researchers find obesity linked to reduced blood flow to the brain Trinity College Dublin (Ireland), May 5, 2021 A new study from scientists at The Irish Longitudinal Study on Aging (TILDA) at Trinity College Dublin reveals important findings, indicating that being overweight or obese significantly reduces blood flow in the brain. The study also shows that increased physical activity can positively modify, or even negate, this reduction in brain blood flow. The study contains relevant information which is of great interest to the general public; since reduced blood flow in the brain, or 'cerebral hypoperfusion," is an early mechanism in vascular dementia and Alzheimer's disease. Obesity and health challenges According to the World Health Organization (WHO), obesity is a worsening health crisis that has reached epidemic proportions globally, with over 1 billion adults overweight—and at least 300 million clinically obese. It continues to be a major contributor to global rates of chronic disease and disability, affecting overall quality of life, while placing increased strain on the immune system which is of the upmost importance given the current COVID-19 situation. Obesity is also a significant public health concern given its negative impact on physiological function, especially as we age. Finding easily implemented and cost-effective ways to tackle the impact of obesity is particularly important to help protect against negative health outcomes in later life. What are the findings of the TILDA study? The study investigates three different measures of obesity—body mass index (BMI), waist-to-hip ratio and waist circumference, as well as physical activity, in adults over 50 years. Brain blood flow was measured using cutting-edge MRI scanning and analysis techniques. The findings reveal that being overweight or obese is associated with reduced blood supply to the brain. Whereas brain blood flow is known to decline with age, in this study the negative influence of obesity on brain blood flow was shown to be greater than that of age. However, being physically active helps to cancel out the negative effects of obesity on brain blood flow. Key Findings ncreased BMI, waist-to-hip ratio, and waist size are associated with less blood supply to the brain. A waist size increase of +1cm is associated with the same reduction in brain blood flow as +1 year of age. Higher levels of physical activity modify the associations between reduced brain blood flow and obesity. Recommendations The study recommends at least 1.5 to two hours of 'being active' throughout the day, engaging in activities that require moderate effort. These include activities that cause one to breathe harder than normal, such as fast walking or cycling. However, any increase in physical activity, particularly if integrated into daily or weekly habits, such as gardening, should help maintain and potentially improve brain blood flow. Dr. Silvin Knight, Research Fellow at TILDA and lead author, said: Consistent, healthy blood supply to the brain is critical, as it ensures that the brain is provided with enough oxygen and nutrients to function correctly. If brain blood flow becomes impaired, it can lead to serious health issues as we age, such as increasing the risk of dementia and Alzheimer's disease. We know that obesity can predispose a person to age-related conditions, illness, and disease, and even reduce life expectancy by up to six years in men and seven years in women, after the age of forty. Our study reveals clear associations between obesity and reduced blood supply to the brain in an older population. The study also shows the importance of being physically active for older overweight or obese individuals, as this may help to protect against reduced brain blood flow and the poor health outcomes that can arise from this. Professor Rose Anne Kenny, Principal Investigator of TILDA, and co-author of the study, said: "Many experts have shown that obesity and aging have very similar effects on the biology of aging; diseases associated with obesity are similar to those of aging and age-related diseases—heart disease, diabetes, high blood pressure, kidney failure, arthritis, susceptibility to infections- including COVID-19." Our study not only shows that there is a link between obesity and reduced brainblood flow, but also that it is possible to protect against the negative consequences of obesity through regular physical exercise. Whereas these findings are of relevance in the global context, because of the rapidly evolving global burden of obesity, the research is especially important to Irish adults because obesity and being overweight is a considerable health issue in Ireland. Previous TILDA research has shown that over one-third of Irish adults aged 50 and older are obese and a further 43% overweight. As we prepare our society for a growing aging population, we can use this evidence to prepare meaningful public health policies that will promote impactful and positive lifestyle habits, such as regular physical activity, to mitigate against some of the negative consequences of the growing obesity crisis.           In silico screening of Chinese herbal medicines with the potential to directly inhibit 2019 novel coronavirus Shanghai Health Commission Key Lab of Artificial Intelligence (AI)-Based Management of Inflammation and Chronic Diseases, May 2, 2021 Objective In this study we execute a rational screen to identify Chinese medical herbs that are commonly used in treating viral respiratory infections and also contain compounds that might directly inhibit 2019 novel coronavirus (2019-nCoV), an ongoing novel coronavirus that causes pneumonia. Methods There were two main steps in the screening process. In the first step we conducted a literature search for natural compounds that had been biologically confirmed as against sever acute respiratory syndrome coronavirus or Middle East respiratory syndrome coronavirus. Resulting compounds were cross-checked for listing in the Traditional Chinese Medicine Systems Pharmacology Database. Compounds meeting both requirements were subjected to absorption, distribution, metabolism and excretion (ADME) evaluation to verify that oral administration would be effective. Next, a docking analysis was used to test whether the compound had the potential for direct 2019-nCoV protein interaction. In the second step we searched Chinese herbal databases to identify plants containing the selected compounds. Plants containing 2 or more of the compounds identified in our screen were then checked against the catalogue for classic herbal usage. Finally, network pharmacology analysis was used to predict the general in vivo effects of each selected herb. Results Of the natural compounds screened, 13 that exist in traditional Chinese medicines were also found to have potential anti-2019-nCoV activity. Further, 125 Chinese herbs were found to contain 2 or more of these 13 compounds. Of these 125 herbs, 26 are classically catalogued as treating viral respiratory infections. Network pharmacology analysis predicted that the general in vivo roles of these 26 herbal plants were related to regulating viral infection, immune/inflammation reactions and hypoxia response. Conclusion Of course, it should be pointed out that Chinese herbs that have not been identified through this screening process may still have beneficial effects. Further, considering that the biologically validated natural compounds reported in the literature cannot cover all antiviral natural compounds, and the natural compounds included in the Chinese medicine database are not complete, the process that we have followed may have excluded herbs that would be well suited to this treatment. Nevertheless, the purpose of this screening was to provide a rational approach for selecting Chinese herbal medicines with a high potential efficacy in treating 2019-nCoV and related viruses. The specific dosage and usage of each herb should be determined based on patients’ manifestations. Finally, the key step in this screening was molecular docking. The 3D structures of the proteins used here are based on reported gene sequences. If the virus mutates during transmission, a new screening is recommended. In conclusion, this work has identified several Chinese medicinal plants classified as antiviral/pneumonia-effective that might directly inhibit the novel coronavirus, 2019-nCoV. Additionally, we propose screening principles and methods which may provide guidance in screening antiviral drugs from other natural drug databases.     Ginkgolide B monotherapy reverses osteoporosis by regulating oxidative stress-mediated bone homeostasis   Chinese University of Hong Kong, May 4, 2021 According to news reporting from Hong Kong, People’s Republic of China, research stated, “Osteoporosis is characterized by reductions in bone mass, which could be attributed to the dysregulation of bone homeostasis, such as the loss of balance between bone-resorbing osteoclasts and bone-forming osteoblasts. Elevated levels of oxidative stress increase bone resorption by promoting osteoclastogenesis and inhibiting the osteogenesis.” The news correspondents obtained a quote from the research from the Chinese University of Hong Kong, “Ginkgolide B (GB), a small natural molecule from Ginkgo biloba, has been reported to possess pharmacological activities by regulating reactive oxygen species (ROS) in aging-related degenerative diseases. Herein, we assessed the therapeutic effects of GB on the bone phenotypes of mice with osteoporosis induced by (I) aging, (II) ovariectomy, and (III) glucocorticoids. In all three animal models, oral gavage of GB significantly improved bone mass consistent with the increase in the OPG-to-RANKL ratio. In the in vitro experiments, GB promoted osteogenesis in aged mesenchymal stem cells (MSCs) and repressed osteoclastogenesis in aged macrophages by reducing ROS. The serum protein profile in GB-treated aged mice revealed moderate rejuvenating effects; signaling pathways associated with ROS were also regulated. The anabolic and anti-catabolic effects of GB were illustrated by the reduction in ROS. Our results indicate that GB is effective in treating osteoporosis.” According to the news reporters, the research concluded: “The use of GB in patients with osteoporosis is worthy of further clinical investigation.” This research has been peer-reviewed.