Podcasts about mscs

Wellness + Wisdom | Episode 750 Does AI hold the key to fixing the modern healthcare system that's keeping us sick? Nathan Graville, CEO + Co-Founder of Geviti, joins Josh Trent on the Wellness + Wisdom Podcast, episode 750, to reveal why “feeling good” and “being healthy” are two very different things, how routine blood tests can expose hidden inflammation before it becomes disease, why reactive care driven by Big Pharma benefits from keeping you sick, and how AI doctors can help you reclaim ownership of your health. "Within the next 5 years, everybody is going to have an AI doctor in their pocket, and the whole traditional healthcare system is going to be reshaped forever. That's how we make longevity accessible to everybody, and it will be completely normal to live into our 120s, 130s, 140s." - Nathan Graville 20% Off Geviti Geviti offers cutting-edge health solutions tailored to various wellness needs, from longevity and hormone health to weight management and sexual vitality. Geviti's personalized approach includes regular consultations and follow-up tests, ensuring that each aspect of a customer's health regimen is optimized for their current state of health. Whether you're addressing specific health issues or aiming to enhance overall well-being, Geviti's comprehensive testing and personalized health plans provide the tools and support necessary for achieving optimal health. 20% OFF GEVITI Use code JOSH20 at checkout In This Episode, Nathan Graville Uncovers: [01:05] Feeling Good ≠ Healthy Nathan Graville Geviti Why feeling fine doesn't mean that we are healthy. How being fit doesn't equal being healthy. The importance of getting blood tested. Why doctors usually don't test C-reactive protein. [05:15] Proactive Health Care Why proactive care is the only way to achieve true health. How Big Pharma benefits from us being sick. What tools can help us measure our health. How preventative care has become more accessible in the past 10 years. [08:05] How to Optimize Your Health for Longevity Why longevity doctors are extremely expensive and hard to find. How AI makes longevity accessible to everybody. Why longevity shouldn't be obsessive. The role of mental health in our lifespan. How traditional healthcare is going to change with the rise of AI. [13:30] AI Bias: Can You Really Trust ChatGPT? How AI is evolving faster than we think. Why people assume that every output AI provides is accurate. How AI gives us very convincing responses to things we don't know anything about. Why the right prompting creates more valid results. The longer we collect our data with Geviti, the better data it gives us about our health. [19:05] From Grief to Helping Others Why Nathan believes his father still exists in a different form after passing. How Geviti could have saved his father. Why the pandemic made it difficult to get proper care. How Nathan created Geviti to honor his father. Why Nathan changed his opinion on psychotherapy. How therapy helped him heal through being vulnerable. [28:10] Modern Health Care Is A Profit-Making Machine Why the medical system is good at fixing injuries. How reactive care is highly profitable, and there's an incentive to keep people sick. Why Make America Healthy Again draws attention to the problems of the healthcare system. How we shouldn't expect our doctors to own our health. Why we need to take down Big Pharma. How Geviti is not profit first, but people first. [34:45] Are You Living to Work? Conscious Capitalism by John Mackey + Raj Sisodia How our bodies respond to nervous system dysregulation. Why we are misaligned in our priorities, and we live to work. How Nathan puts God first, family second, and work third. [39:10] Biological Age Testing How Josh discovered that his biological age was much younger than his chronological age. Why getting blood work is the first step, then we need to take action. How Geviti provides practical tools and a team to support your journey. Why assessing biological age has changed and there are several different methods. How biological age testing shows how we're improving our longevity. Why basic lifestyle changes can decrease our biological age. [46:35] Methylation + Supplementation 734 Kirk Parsley MD | Sleep As Medicine: How To Sleep Like Royalty + Stop Being Sick How Geviti ensures the accuracy of their lab tests. What labs they're working with for diagnostic solutions. 694 Shawn Wells | Your Ultimate Guide To Healing Mental + Physical Health How 30-40% of people struggle with methylation. Why many supplements are not bioavailable and don't absorb into the body. How supplements are meant to be used for the best effect. Why supplementation must be data driven. [54:55] Can You Rely on Technology with Your Health? NOOTOPIA (10% off with code JOSH10) How older generations don't trust technology as much as younger people. Why we can't hear what our body's telling us it needs. How Geviti protects their clients' data. Why technology is a part of human evolution. How using technology doesn't mean we're going against nature. [01:00:45] Peptides: Nature's Miracle? Peptides already exist in our bodies and are completely natural. How peptides bind to the receptors of our cells and support healing. Why peptides are a threat to Big Pharma. How exogenous growth hormones can cause serious health issues. Why we should only buy peptides from pharmacies. How research chemical companies produce peptides that can be very harmful. [01:09:15] The Future of Health Why Eli Lilly is going against compounding pharmacies. We need more compounding pharmacies in order to make health products more accessible. How we can decentralize health information. Why we could invent cures to all diseases if we established a decentralized database. How human nature might stop us from creating a new system. [01:16:20] Trust Your Intuition Why everyone has access to intuition. How our intuition gets clouded. Why people fall for snake oil supplements. How we can judge a company by their founder. Why we always have a gut feeling at the beginning that tells us the truth. How some supplements work for some people but don't work for others. Why companies don't need to rely on third-party studies anymore. [01:25:00] Geviti Can Save Your Life + Time How Geviti has helped people diagnose cancer and cardiovascular disease. Why Geviti saves us time compared to going to a doctor's office. The importance of designing products around mothers and busy entrepreneurs. [01:29:00] AI for Longevity Why in the future most people will live to be over 100. How AI will create abundance and make services more accessible. Why Geviti's costs have gone down since the rise of AI. [01:33:50] Heal Your Body with Stem Cells Why stem cell treatments are becoming more popular. Joy Kong MD How Geviti is developing a stem cell product from umbilical cords. Why MSC stem cells target what needs to be healed. How one stem cell IV saved a man's life whose liver was failing. Why peptides and stem cells are going to help us live longer. Leave Wellness + Wisdom a Review on Apple Podcasts Power Quotes From The Show Big Pharma Wants You Sick! "There's incentive to keep people sick because Big Pharmaceutical will profit off of it, and then they'll prescribe the medications and the medications to combat the side effects of their own medications. It's a vicious cycle that's very hard to escape." - Nathan Graville Peptides + MSCs "Peptides and MSCs are the future of longevity. These are two therapeutics that will get us to living into our hundreds. When you do a MSC IV, it's going to find out where in your body you need healing and it's going to go to those areas on its own. This is potentially the most powerful therapeutic that we know about in existence as it relates to longevity." - Nathan Graville Feeling Healthy Doesn't Equal Being Healthy "There's no way to know if you're healthy based on just how you feel. You can have elevated markers that are directly correlated to all-cause mortality. Which is why looking underneath the hood is so crucially important. The only way to know is by doing a routine blood work." - Nathan Graville Links From Today's Show  Nathan Graville Geviti Conscious Capitalism by John Mackey + Raj Sisodia 734 Kirk Parsley MD | Sleep As Medicine: How To Sleep Like Royalty + Stop Being Sick 694 Shawn Wells | Your Ultimate Guide To Healing Mental + Physical Health NOOTOPIA (10% off with code JOSH10) Joy Kong MD   Josh's Trusted Products | Up To 40% Off Shop All Products Biohacking⁠ MANNA Vitality - Save 20% with code JOSH20 HigherDOSE - 15% off with the code WELLNESSANDWISDOM PLUNGE - $150 off with discount code WELLNESSFORCE Pulsetto - Save 20% with code "JOSH" SaunaSpace - 10% off with discount code JOSH10 Ultrahuman Ring Air - 10% off with code JOSH NutriSense - 30% off with WELLNESSFORCE Wellness Test Kits Choose Joi - Save 50% on all Lab Tests with JOSH Blokes - Save 50% on all Lab Tests with JOSH FertilityWize Test by Clockwize - Save 10% with code JOSH Tiny Health Gut Tests - $20 off with discount code JOSH20 VIVOO Health Tests - Save 30% off with code JOSH SiPhox Health Blood Test - Save 15% off with code JOSH Nutrition + Gut Health Organifi - 20% off with discount code WELLNESSFORCE SEED Synbiotic - 25% off with the code 25JOSHTRENT Paleovalley -  Save 15% off here! 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His commitment to building technology for positive impact is currently centered on increasing both healthspan and lifespan. He designs and builds products to enhance user experiences and improve lives, and is fueled by the desire to challenge the status quo and deliver meaningful change to the world. Nathan is driven by the prospect of bringing impactful projects to life and aims to create positive change on a global scale. Website Instagram Facebook YouTube

If you've ever worked in a cell therapy lab or handled biologics, you've probably experienced the pitfalls of cryopreservation. We've all mourned the loss of precious samples after a freeze-thaw cycle gone wrong or watched viability figures plummet, wondering where it all went awry.In this episode of The Smart Biotech Scientist Podcast, Jeffrey Allen, Chairman and CEO of Evia Bio, shares how nature-inspired solutions are changing the cell preservation game. With a background spanning finance, operations, and leadership across the biotech landscape, Jeffrey brings a unique perspective on bridging science and practical manufacturing needs.Inspired by the survival strategies of Minnesota's frozen forests, a new wave of biotech innovation is transforming the way we freeze, store, and ship life-saving cells for therapies - and it all starts with a better understanding of nature.Here are the top three takeaways from this podcast episode:Cryopreservation shouldn't be an afterthought: Building optimal cryopreservation strategies into your process development from day one can avoid costly setbacks and delays.Beyond cell viability - function matters: It's not just about how many cells survive the freeze/thaw cycle, but whether those cells remain fully functional. Evia Bio's new DMSO-free formulations are delivering >85% recovery on MSCs without compromising cell function.One size doesn't fit all: Every cell type has unique needs for freezing, thawing, and formulation. Leveraging tailored algorithms and customized protocols can drastically improve yield and reproducibility, potentially reducing the need for costly overfilling in manufacturing.If you've ever lost precious cell samples to a freeze-thaw mishap or questioned why you're stuck with outdated, toxic cryopreservation methods, this episode is for you!Connect with Jeffrey Allen:LinkedIn: www.linkedin.com/in/jeffreydallen2Website: www.eviabio.comEmail: jeffrey.allen@eviabio.comNext step:Book a free consultation to help you get started on any questions you may have about bioprocessing analytics: https://bruehlmann-consulting.com/callDevelop bioprocessing technologies better, faster, at a fraction of the cost with our 1:1 Strategy Call: The quickest and easiest way to excel biotech technology development. Book your call at www.bruehlmann-consulting.com/call/Support the show

Dr. Kilian Kelly, Chief Executive Officer and Managing Director of Cynata Therapeutics, has taken on the challenge of manufacturing stem cell therapies consistently and at scale in order to drive the advancements necessary for the next generation of regenerative medicine. Cynata is employing a novel approach that utilizes a single source of pluripotent stem cells (iPSCs) and mesenchymal cell ancestors (MCAs) to generate mesenchymal stem cells (MSCs). Lead programs are targeting graft-versus-host disease, osteoarthritis, and diabetic wounds, where clinical trials have shown great promise to treat these and other diseases. Kilian explains, "We're a stem cell regenerative medicine company, and what we're trying to do is to change the way that we can manufacture stem cell therapies in a consistent and scalable way. I'm sure many of your listeners have heard about stem cell therapies of various types. The particular type of cells that we're working on are called mesenchymal stem cells or MSCs. They've shown lots of promise for lots of different purposes, but a real challenge has been making these cells consistently, especially when you try to do that at a large scale. We have a unique novel manufacturing platform, which helps us to address that major challenge." "The way that these cells were historically produced and indeed still are produced in most cases is by harvesting cells from, for example, somebody donating bone marrow or adipose tissue, also known as fat. And those approaches have certainly allowed a lot of early-stage clinical trials to be performed, which showed lots of really exciting results. But often what happens is that when you move to a larger scale using such a process, and you try to make much larger quantities of cells, perhaps using many different donors, you start to see a lot of inconsistency. There are a few reasons for this. When you have inconsistency with a product, it's inevitable that you're going to get inconsistent results." "If you have inconsistent results in a clinical trial, it becomes a bit of a lottery, and sometimes you can have very disappointing results that are hard to explain. So we think that's been a really big issue that has caused a lot of problems in the field. And aside from the impact on clinical trial results, we also need to think about the future when these products are available and on the market, and how you can actually, in practical terms, produce enough of these products. So, in a nutshell, I think that is probably the major challenge that the field has faced."  #CynataTherapeutics #StemCellTherapy #RegenerativeMedicine #iPSCs #MSCs #MCAs Cynata.com Download the transcript here  

Dr. Kilian Kelly, Chief Executive Officer and Managing Director of Cynata Therapeutics, has taken on the challenge of manufacturing stem cell therapies consistently and at scale in order to drive the advancements necessary for the next generation of regenerative medicine. Cynata is employing a novel approach that utilizes a single source of pluripotent stem cells (iPSCs) and mesenchymal cell ancestors (MCAs) to generate mesenchymal stem cells (MSCs). Lead programs are targeting graft-versus-host disease, osteoarthritis, and diabetic wounds, where clinical trials have shown great promise to treat these and other diseases. Kilian explains, "We're a stem cell regenerative medicine company, and what we're trying to do is to change the way that we can manufacture stem cell therapies in a consistent and scalable way. I'm sure many of your listeners have heard about stem cell therapies of various types. The particular type of cells that we're working on are called mesenchymal stem cells or MSCs. They've shown lots of promise for lots of different purposes, but a real challenge has been making these cells consistently, especially when you try to do that at a large scale. We have a unique novel manufacturing platform, which helps us to address that major challenge." "The way that these cells were historically produced and indeed still are produced in most cases is by harvesting cells from, for example, somebody donating bone marrow or adipose tissue, also known as fat. And those approaches have certainly allowed a lot of early-stage clinical trials to be performed, which showed lots of really exciting results. But often what happens is that when you move to a larger scale using such a process, and you try to make much larger quantities of cells, perhaps using many different donors, you start to see a lot of inconsistency. There are a few reasons for this. When you have inconsistency with a product, it's inevitable that you're going to get inconsistent results." "If you have inconsistent results in a clinical trial, it becomes a bit of a lottery, and sometimes you can have very disappointing results that are hard to explain. So we think that's been a really big issue that has caused a lot of problems in the field. And aside from the impact on clinical trial results, we also need to think about the future when these products are available and on the market, and how you can actually, in practical terms, produce enough of these products. So, in a nutshell, I think that is probably the major challenge that the field has faced."  #CynataTherapeutics #StemCellTherapy #RegenerativeMedicine #iPSCs #MSCs #MCAs Cynata.com Listen to the podcast here  

In this podcast episode, Dr. Kilian Kelly, CEO of Cynata Therapeutics, discusses the future of regenerative medicine! Discover how mesenchymal stem cells (MSCs)—powerful cells that repair and regenerate tissues—are revolutionizing treatments for a range of diseases. Dr. Kelly shares insights on Cynata's groundbreaking Cymerus™ platform and the exciting potential of MSC therapies.

Episode Notes My guests include MSCS board member Tamarques Porter. A lot has happened the last few months and as we put the wrap on another school year, I ask him how challenging it's been and what he hopes to see moving forward. Next, speaking of challenges, crime continues to a major concern in the city and for the law enforcement community. Memphis Police Association VP John Covington joins me to discuss manpower issues and where morale is within the department as a whole. Finally, the story of a man who contracted COVID, was hospitalized for over 40 days on a respirator and ventilator and was very close to death. Rev. Dr. Chuck Lester has an inspirational story to share and a new book detailing his amazing story that he simply calls, A Real Time Miracle. That and more both on air and online Monday, 6 pm on 91.7 WYXR. Also, the wyxr app, Tunein, Facebook Live, YouTube and wherever you get your podcasts. It's time to talk!

Episode Notes My guests include MSCS board member Tamarques Porter. A lot has happened the last few months and as we put the wrap on another school year, I ask him how challenging it's been and what he hopes to see moving forward. Next, speaking of challenges, crime continues to a major concern in the city and for the law enforcement community. Memphis Police Association VP John Covington joins me to discuss manpower issues and where morale is within the department as a whole. Finally, the story of a man who contracted COVID, was hospitalized for over 40 days on a respirator and ventilator and was very close to death. Rev. Dr. Chuck Lester has an inspirational story to share and a new book detailing his amazing story that he simply calls, A Real Time Miracle. That and more both on air and online Monday, 6 pm on 91.7 WYXR. Also, the wyxr app, Tunein, Facebook Live, YouTube and wherever you get your podcasts. It's time to talk!

En este episodio, profundizamos en uno de los fenómenos más devastadores pero menos comprendidos en neurorrehabilitación: la denervación muscular tras una lesión medular. A través de una revisión exhaustiva de la literatura científica y de la experiencia clínica, abordamos qué ocurre realmente con los músculos que han perdido su inervación, cómo se transforman con el tiempo y qué posibilidades tenemos para intervenir. Hablamos sobre neurofisiología, degeneración axonal, fases de la denervación, y cómo la estimulación eléctrica —especialmente con pulsos largos— puede modificar el curso degenerativo incluso años después de la lesión. Exploramos también el Proyecto RISE, los protocolos clínicos actuales y las implicaciones terapéuticas reales de aplicar electroestimulación en músculos completamente denervados. Si trabajas en neurorrehabilitación o te interesa la ciencia aplicada a la recuperación funcional, este episodio es para ti. Referencias del episodio: 1. Alberty, M., Mayr, W., & Bersch, I. (2023). Electrical Stimulation for Preventing Skin Injuries in Denervated Gluteal Muscles-Promising Perspectives from a Case Series and Narrative Review. Diagnostics (Basel, Switzerland), 13(2), 219. https://doi.org/10.3390/diagnostics13020219 (https://pubmed.ncbi.nlm.nih.gov/36673029/). 2. Beauparlant, J., van den Brand, R., Barraud, Q., Friedli, L., Musienko, P., Dietz, V., & Courtine, G. (2013). Undirected compensatory plasticity contributes to neuronal dysfunction after severe spinal cord injury. Brain : a journal of neurology, 136(Pt 11), 3347–3361. https://doi.org/10.1093/brain/awt204 (https://pubmed.ncbi.nlm.nih.gov/24080153/). 3. Bersch, I., & Fridén, J. (2021). Electrical stimulation alters muscle morphological properties in denervated upper limb muscles. EBioMedicine, 74, 103737. https://doi.org/10.1016/j.ebiom.2021.103737 (https://pubmed.ncbi.nlm.nih.gov/34896792/). 4. Bersch, I., & Mayr, W. (2023). Electrical stimulation in lower motoneuron lesions, from scientific evidence to clinical practice: a successful transition. European journal of translational myology, 33(2), 11230. https://doi.org/10.4081/ejtm.2023.11230 (https://pmc.ncbi.nlm.nih.gov/articles/PMC10388603/). 5. Burnham, R., Martin, T., Stein, R., Bell, G., MacLean, I., & Steadward, R. (1997). Skeletal muscle fibre type transformation following spinal cord injury. Spinal cord, 35(2), 86–91. https://doi.org/10.1038/sj.sc.3100364 (Burnham, R., Martin, T., Stein, R., Bell, G., MacLean, I., & Steadward, R. (1997). Skeletal muscle fibre type transformation following spinal cord injury. Spinal cord, 35(2), 86–91. https://doi.org/10.1038/sj.sc.3100364). 6. Carlson B. M. (2014). The Biology of Long-Term Denervated Skeletal Muscle. European journal of translational myology, 24(1), 3293. https://doi.org/10.4081/ejtm.2014.3293 (https://pubmed.ncbi.nlm.nih.gov/26913125/). 7. Carraro, U., Boncompagni, S., Gobbo, V., Rossini, K., Zampieri, S., Mosole, S., Ravara, B., Nori, A., Stramare, R., Ambrosio, F., Piccione, F., Masiero, S., Vindigni, V., Gargiulo, P., Protasi, F., Kern, H., Pond, A., & Marcante, A. (2015). Persistent Muscle Fiber Regeneration in Long Term Denervation. Past, Present, Future. European journal of translational myology, 25(2), 4832. https://doi.org/10.4081/ejtm.2015.4832 (https://pubmed.ncbi.nlm.nih.gov/26913148/). 8. Chandrasekaran, S., Davis, J., Bersch, I., Goldberg, G., & Gorgey, A. S. (2020). Electrical stimulation and denervated muscles after spinal cord injury. Neural regeneration research, 15(8), 1397–1407. https://doi.org/10.4103/1673-5374.274326 (https://pubmed.ncbi.nlm.nih.gov/31997798/). 9. Ding, Y., Kastin, A. J., & Pan, W. (2005). Neural plasticity after spinal cord injury. Current pharmaceutical design, 11(11), 1441–1450. https://doi.org/10.2174/1381612053507855 (https://pmc.ncbi.nlm.nih.gov/articles/PMC3562709/). 10. Dolbow, D. R., Bersch, I., Gorgey, A. S., & Davis, G. M. (2024). The Clinical Management of Electrical Stimulation Therapies in the Rehabilitation of Individuals with Spinal Cord Injuries. Journal of clinical medicine, 13(10), 2995. https://doi.org/10.3390/jcm13102995 (https://pubmed.ncbi.nlm.nih.gov/38792536/). 11. Hofer, C., Mayr, W., Stöhr, H., Unger, E., & Kern, H. (2002). A stimulator for functional activation of denervated muscles. Artificial organs, 26(3), 276–279. https://doi.org/10.1046/j.1525-1594.2002.06951.x (https://pubmed.ncbi.nlm.nih.gov/11940032/). 12. Kern, H., Hofer, C., Mödlin, M., Forstner, C., Raschka-Högler, D., Mayr, W., & Stöhr, H. (2002). Denervated muscles in humans: limitations and problems of currently used functional electrical stimulation training protocols. Artificial organs, 26(3), 216–218. https://doi.org/10.1046/j.1525-1594.2002.06933.x (https://pubmed.ncbi.nlm.nih.gov/11940016/). 13. Kern, H., Salmons, S., Mayr, W., Rossini, K., & Carraro, U. (2005). Recovery of long-term denervated human muscles induced by electrical stimulation. Muscle & nerve, 31(1), 98–101. https://doi.org/10.1002/mus.20149 (https://pubmed.ncbi.nlm.nih.gov/15389722/). 14. Kern, H., Rossini, K., Carraro, U., Mayr, W., Vogelauer, M., Hoellwarth, U., & Hofer, C. (2005). Muscle biopsies show that FES of denervated muscles reverses human muscle degeneration from permanent spinal motoneuron lesion. Journal of rehabilitation research and development, 42(3 Suppl 1), 43–53. https://doi.org/10.1682/jrrd.2004.05.0061 (https://pubmed.ncbi.nlm.nih.gov/16195962/). 15. Kern, H., Carraro, U., Adami, N., Hofer, C., Loefler, S., Vogelauer, M., Mayr, W., Rupp, R., & Zampieri, S. (2010). One year of home-based daily FES in complete lower motor neuron paraplegia: recovery of tetanic contractility drives the structural improvements of denervated muscle. Neurological research, 32(1), 5–12. https://doi.org/10.1179/174313209X385644 (https://pubmed.ncbi.nlm.nih.gov/20092690/). 16. Kern, H., & Carraro, U. (2014). Home-Based Functional Electrical Stimulation for Long-Term Denervated Human Muscle: History, Basics, Results and Perspectives of the Vienna Rehabilitation Strategy. European journal of translational myology, 24(1), 3296. https://doi.org/10.4081/ejtm.2014.3296 (https://pmc.ncbi.nlm.nih.gov/articles/PMC4749003/). 17. Kern, H., Hofer, C., Loefler, S., Zampieri, S., Gargiulo, P., Baba, A., Marcante, A., Piccione, F., Pond, A., & Carraro, U. (2017). Atrophy, ultra-structural disorders, severe atrophy and degeneration of denervated human muscle in SCI and Aging. Implications for their recovery by Functional Electrical Stimulation, updated 2017. Neurological research, 39(7), 660–666. https://doi.org/10.1080/01616412.2017.1314906 (https://pubmed.ncbi.nlm.nih.gov/28403681/). 18. Kern, H., & Carraro, U. (2020). Home-Based Functional Electrical Stimulation of Human Permanent Denervated Muscles: A Narrative Review on Diagnostics, Managements, Results and Byproducts Revisited 2020. Diagnostics (Basel, Switzerland), 10(8), 529. https://doi.org/10.3390/diagnostics10080529 (https://pubmed.ncbi.nlm.nih.gov/32751308/). 19. Ko H. Y. (2018). Revisit Spinal Shock: Pattern of Reflex Evolution during Spinal Shock. Korean journal of neurotrauma, 14(2), 47–54. https://doi.org/10.13004/kjnt.2018.14.2.47 (https://pubmed.ncbi.nlm.nih.gov/30402418/). 20. Mittal, P., Gupta, R., Mittal, A., & Mittal, K. (2016). MRI findings in a case of spinal cord Wallerian degeneration following trauma. Neurosciences (Riyadh, Saudi Arabia), 21(4), 372–373. https://doi.org/10.17712/nsj.2016.4.20160278 (https://pmc.ncbi.nlm.nih.gov/articles/PMC5224438/). 21. Pang, Q. M., Chen, S. Y., Xu, Q. J., Fu, S. P., Yang, Y. C., Zou, W. H., Zhang, M., Liu, J., Wan, W. H., Peng, J. C., & Zhang, T. (2021). Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar. Frontiers in immunology, 12, 751021. https://doi.org/10.3389/fimmu.2021.751021 (https://pubmed.ncbi.nlm.nih.gov/34925326/). 22. Schick, T. (Ed.). (2022). Functional electrical stimulation in neurorehabilitation: Synergy effects of technology and therapy. Springer. https://doi.org/10.1007/978-3-030-90123-3 (https://link.springer.com/book/10.1007/978-3-030-90123-3). 23. Swain, I., Burridge, J., & Street, T. (Eds.). (2024). Techniques and technologies in electrical stimulation for neuromuscular rehabilitation. The Institution of Engineering and Technology. https://shop.theiet.org/techniques-and-technologies-in-electrical-stimulation-for-neuromuscular-rehabilitation 24. van der Scheer, J. W., Goosey-Tolfrey, V. L., Valentino, S. E., Davis, G. M., & Ho, C. H. (2021). Functional electrical stimulation cycling exercise after spinal cord injury: a systematic review of health and fitness-related outcomes. Journal of neuroengineering and rehabilitation, 18(1), 99. https://doi.org/10.1186/s12984-021-00882-8 (https://pubmed.ncbi.nlm.nih.gov/34118958/). 25. Xu, X., Talifu, Z., Zhang, C. J., Gao, F., Ke, H., Pan, Y. Z., Gong, H., Du, H. Y., Yu, Y., Jing, Y. L., Du, L. J., Li, J. J., & Yang, D. G. (2023). Mechanism of skeletal muscle atrophy after spinal cord injury: A narrative review. Frontiers in nutrition, 10, 1099143. https://doi.org/10.3389/fnut.2023.1099143 (https://pubmed.ncbi.nlm.nih.gov/36937344/). 26. Anatomical Concepts: https://www.anatomicalconcepts.com/articles

How safe is stem cell therapy? If you think about getting one, but are terrified of what might go wrong, this episode is for you.As someone who's worked with regenerative medicine for years, I understand the excitement—and the concerns. From immune reactions to infection risks, misinformation can, most of the time, fuel fear.But here's the truth: only two things matter in stem cell therapy—the quality of the cells and where to put them.In this week's episode, I explain exactly what can go wrong—and what needs to go right—for stem cell therapy to work without harmful side effects.From the source of your cells to the way they're injected into your body, I break down everything you need to know about stem cell therapy side effects.You'll also learn why umbilical cord-derived stem cells are currently the gold standard, the 2018 Livyon contamination case, and how using your own aging stem cells could pose serious risks.Listen in and find out what every patient should know before undergoing stem cell therapy.Let's dive in!Key Takeaways:Introduction (00:00)Risks of using your own aging cells (00:27)Is umbilical cord stem cell therapy safe? (05:34)Livyon incident and contamination (07:38)Dangers of cell expansion (09:58)Role of mesenchymal stem cells (MSCs) (12:25)Injection areas during stem cell therapy matter (14:23)Cold and flu as side effects (18:06)Can stem cell therapy cause a rash? (21:52)Fatigue or vasovagal reactions (24:19)Additional Resources:✨ Use coupon code DRJOY to get 10% off your purchase of methylene blue products: https://www.best365labs.com/ ✨ Learn more about how to live a long and pain-free life: https://joykongmd.com/ ✨ Follow me on Facebook: https://www.facebook.com/stemcelldrjoy/ ✨ Follow me on Instagram: https://www.instagram.com/dr_joy_kong/ —Dr. Joy Kong is a regenerative medicine and anti-aging expert. Her podcast is part of her mission to reduce suffering and elevate happiness. Join us every week for the latest holistic health insights that will help you live a long and pain-free life.

Tennessee representative Mark White tells Memphis Morning News' Ditch & Tim Van Horn modifications to his bill that could give an appointed oversight board the ability to veto MSCS actions in such things as the budget. The advisory board members would be from Shelby County. White also answered questions regarding his vote in favor of HB855 Support the show: https://www.newstalk989.com/personalities/memphis-morning-news/See omnystudio.com/listener for privacy information.

Continuing our celebration of Occupational Therapy Month, this week we chat with FOX Rehabilitation's Cristina Klymasz, MS, OTR/L, CBIS, RYT, CLT-LANA, MSCS, who talks about incorporating yoga into her occupational therapy sessions. Cristina details how a team morale event at a yoga studio made her realize how much it could benefit her patients. Being the go-getter she is, Cristina got her yoga license—not with dreams of opening her studio—but with the main intent of helping her patients. Cristina admits some patients are skeptical when the concept of yoga is brought up. Still, the results are turning doubters into believers, especially with its numerous benefits, including helping patients with their balance. Cristina also discusses how she will be spending Occupational Therapy Month and what kind of personality generally gravitates to being an OT.

Continuing our celebration of Occupational Therapy Month, this week we chat with FOX Rehabilitation's Cristina Klymasz, MS, OTR/L, CBIS, RYT, CLT-LANA, MSCS, who talks about incorporating yoga into her occupational therapy sessions. Cristina details how a team morale event at a yoga studio made her realize how much it could benefit her patients. Being the go-getter she is, Cristina got her yoga license—not with dreams of opening her studio—but with the main intent of helping her patients. Cristina admits some patients are skeptical when the concept of yoga is brought up. Still, the results are turning doubters into believers, especially with its numerous benefits, including helping patients with their balance. Cristina also discusses how she will be spending Occupational Therapy Month and what kind of personality generally gravitates to being an OT.

Continuing our celebration of Occupational Therapy Month, this week we chat with FOX Rehabilitation's Cristina Klymasz, MS, OTR/L, CBIS, RYT, CLT-LANA, MSCS, who talks about incorporating yoga into her occupational therapy sessions. Cristina details how a team morale event at a yoga studio made her realize how much it could benefit her patients. Being the go-getter she is, Cristina got her yoga license—not with dreams of opening her studio—but with the main intent of helping her patients. Cristina admits some patients are skeptical when the concept of yoga is brought up. Still, the results are turning doubters into believers, especially with its numerous benefits, including helping patients with their balance. Cristina also discusses how she will be spending Occupational Therapy Month and what kind of personality generally gravitates to being an OT.

MSCS board member, Towanna Murphy, issued an apology for threatening to deport a Hispanic woman who called her the 'b-word" and attacked her work on the school board. We break down everything revealed in the messages, and why this makes her and the MSCS look even worse. Also on the show, the stock market boomed after President Trump delayed tariffs on everyone except China. Now, China is playing tough and we react to what Mr. Wonderful's move would be if he were in charge. We also listen to today's Wheel of Weird story, "Waste of Space". See omnystudio.com/listener for privacy information.

The job to have these days is the interim superintendent role for MSCS, where Dr. Roderick Richmond could end up earning nearly half a million dollars for 18 months. The MSCS board will meet tomorrow to vote on it, but is that much money really necessary for a role that has no incentives to perform well? Also on the show, we react to Cory Booker nearly 24-hour ramble on the Senate floor, and we play two epic rounds of Impossible Memphis Trivia. See omnystudio.com/listener for privacy information.

As Memphis Shelby County Schools face a state intervention because of how they made decisions to remove the wildly popular superintendent, Dr. Marie Feagins, County Commissioner Mick Wright called in to Memphis Morning News to discuss creating an advisory group. Support the show: https://www.newstalk989.com/personalities/memphis-morning-news/See omnystudio.com/listener for privacy information.

Learn about the 3 hallmarks of aging here.https://www.alluremedical.com/the-3-hallmarks-of-aging/Dr. Charles Mok discusses the potential of stem cell therapy in strengthening joints and addressing arthritis without the need for joint replacement. He provides an in-depth exploration of mesenchymal stem cells (MSCs), naturally found in body tissues, and their regenerative properties.Originally developed for cancer treatment, stem cells have since been studied for various therapeutic applications. He explains the different types of stem cells, their mechanisms of action, and the techniques used to harvest them from the body. He also examines their role in treating chronic conditions, promoting longevity, and reducing inflammation associated with joint degeneration.Dr. Mok reviews clinical studies demonstrating the positive effects of stem cell therapy and also discusses the success rates and the best options for individuals considering this treatment.Tune in to the Inside The Cure Podcast — Get Stronger Joints with Stem Cell Therapy————————————————————————————————Subscribe to Inside the Cure on Apple Podcasts and leave a 5-star review! https://podcasts.apple.com/us/podcast/inside-the-cure-with-dr-charles-mok/id1495870043?uo=4Read the latest research and advice from Allure Medical: https://www.alluremedical.com/books/ Dr. Charles Mok received his medical degree from Chicago College of Osteopathic Medicine, Chicago, Illinois in 1989. He completed his medical residency at Mount Clemens General Hospital, Mt. Clemens, Michigan. He has worked with laser manufacturing companies to improve their technologies; he has performed clinical research studies and has taught physicians from numerous other states. His professionalism and personal attention to detail have contributed to the success of one of the first medical spas in Michigan.LinkedIn: https://www.linkedin.com/in/charles-mok-4a0432114/Instagram: https://www.instagram.com/alluremedicals/Website: https://www.alluremedical.com/YouTube: https://www.youtube.com/@AllureMedical Amazon Store: https://www.amazon.com/stores/Dr.-Charles-Mok/author/B0791M9FZQ?ref=ap_rdr&store_ref=ap_rdr&isDramIntegrated=true&shoppingPortalEnabled=true #StemCellTherapy #Arthritis #ArthritisTreatment #RegenerativeMedicine #JointHealth #LongLife #HealthyJoints #Longevity #StemCells #MedicalResearch #HealthPodcast 

Episode Notes My guests include State Senator Raumesh Akbari. With so much on the table affecting both Memphis and Shelby County, this legislative session has faced intense focus. She joins me to discuss a state possible takeover of the MSCS Board, the threat to withhold state tax revenue to the tune of $75 million dollars if Memphis moves forward with gun control legislation and how a bill she is co-sponsoring could help fund a new jail. Next, we often hear about the role fathers play in a child's life. Antonio Harvey is the founder and Executive Director of Fathers First Memphis whose mission is to cultivate nurturing and engaged fathers who will enhance the well-being of children. He joins me to discuss its importance and a new partnership with MSCS. That and more, on air and online Monday nite on WYXR 91.7 FM. Also, the WYXR app, Tunein, Facebook Live, YouTube and wherever you get your podcasts. It's time to talk!

Shelby County Commissioners Mickell Lowery and Britney Thornton talked on “Behind The Headlines” about the political boundary between the commission and the MSCS board.

Episode Notes My guests include County Commissioner Mick Wright. He was one of many who disagreed with the MSCS school board in terminating Dr. Marie Feagins. He and a number of his fellow colleagues backed a resolution of no confidence in the board prior to the vote and now the stage is set for a state takeover. I ask him whether he is for or against the move. Next, the President has made it his mission to remove undocumented immigrants from this country for criminal behavior, but does it stop there? Andrew Rankin, ESQ is a local Immigration Atty who is working with many in the Mid South who are very concerned about their future and what might happen to themselves and their families. He explains the options. Lastly, are you familiar with the expression Mane Up? I speak with Racheal Shantal, Executive director of Mane UP Memphis. It's a non-profit organization that helps empower youth and families through mental health services and financial literacy programs. She tells me why programs like this are so vitally important for the future of our community. That and more on air and online Monday nite, 6 pm on 91.7 WYXR. Also, the WYXR app, Tunein, Facebook Live, YouTube and wherever you get your podcasts! It's time to talk.

The “Behind The Headlines” reporters roundtable also reviewed the end of the Tennessee Legislature's special session and the change Regional One Health's new plans.

47 wasted no time for action after being inaugurated, Dave Chappelle with another classic on SNL and MSCS superintendent Dr. Feagins is potentially on the chopping block (again) from being terminated. And of course we have a rundown of quickies from the NFL playoffs to the woman who slept with 1,000 men in 12 hours. #theprezex #inauguration #snl Checkout this episode's show on YouTube: https://youtube.com/live/ogYXcWLzix8Don't forget to catch up on past episodes and run downs on our YouTube channel: ​https://www.youtube.com/@ThePrezExTVBe sure to SUBSCRIBE and LIKE the videos!Follow us on Instagram: https://www.instagram.com/theprezexLike us on Facebook: https://www.facebook.com/theprezexSend all requests and business inquiries via Email: theprezex@gmail.com

DEI has been the topic of discussion for good reason because the Trump administration put out an executive order for companies and organizations to get rid of DEI programs indefinitely. MSCS school board has a new superintendent but the State of TN still plans to take over, Tia Mowry had a change of heart with ex-husband Cory Hardict, Chiefs/Eagles Super Bowl, Cowboys hire a new coach and plenty more.  #dei #trumpadministration #tiamowry #superbowl Checkout this episode's show on YouTube: https://youtube.com/live/OGuh-gM2ffQDon't forget to catch up on past episodes and run downs on our YouTube channel: ​https://www.youtube.com/@ThePrezExTVBe sure to SUBSCRIBE and LIKE the videos!Follow us on Instagram: https://www.instagram.com/theprezexLike us on Facebook: https://www.facebook.com/theprezexSend all requests and business inquiries via Email: theprezex@gmail.com

'This is the real reason MSCS fired Dr. Feagins': K. Durell Cowan

Lawsuits are looming all over the city as Dr. Feagins looks to take MSCS to court after getting fired, Speaker Cameron Sexton confirming the state could take over the MSCS board, and the board now threating to file a lawsuit if the state were to take over. It's a dumpster fire, and local lawyers are gonna eat good this year. Also on the show, we break down the deportations moves Trump made against Columbia over the weekend, and we react to the Kansas City Chiefs heading back to the Super Bowl. See omnystudio.com/listener for privacy information.

Speaker Sexton Says State WILL Takeover MSCS and Declare Board 'Null and Void' 

The board has spoken. Following an emotional, contentious, and lengthy public school board meeting, Dr. Marie Feagins was fired as the superintendent of Memphis-Shelby County Schools on Tuesday night and we break it all down for you. Also on the show, we go over what our listeners would sign as executive orders like fines for not flushing the toilet at work and we try to find who has the highest mileage in their vehicles. Some were flirting with 500k!See omnystudio.com/listener for privacy information.

0:00 start/set the show6:00 Snow in odd places9:00 Finale of the MSCS Board meeting25:00 Grizzlies v. Hornets34:00 Jimmy Butler saga37:00 MLB Hall of Fame class of '2538:00 LeBron's triple-double43:00 DeAngelo Williams1:09:00 STORY TIME1:17:00 Baby Shower etiquette1:23:00 Dan Hurley gotta let 'em know1:27:00 ATL airport issues

It's the second day of Trump's term and during what was supposed to be a prayer ceremony for the President, it turned into an LGBTQ lecture from an activist bishop with a long history of TDS. Also on the show, Dr. Marie Feagins' future is decided tonight by the MSCS, and we play Impossible Tuesday Trivia and Jake got perhaps the most difficult card yet. See omnystudio.com/listener for privacy information.

Mesenchymal stem cells (MSCs) are multipotent adult stem cells which can differentiate into multiple cell types. MSCs can be isolated from the bone marrow, umbilical cord blood, adipose tissue, muscle, and dental pulp. However, the use of these MSCs involves a number of barriers. Human umbilical cord is limited to collection at birth. Bone marrow and fat biopsy are painful and requires general anesthesia. If only there was an easily obtainable method to collect these MSCs, like maybe even once a month, collectable in a little cup, without biopsy. WHAT… use menstrual blood you say?! Menstrual blood-derived mesenchymal stem cells (MenSCs) were first described by Meng et al. in 2007, as a novel source of MSCs. Most of the MenSC are produced by the endometrium. With the potential of multi-directional differentiation, this has spurred a list of preclinical and animal studies looking into the collection of menstrual blood for MSC processing. Men SCs have been investigated for use in Alzheimer's disease, Stroke, Spinal Cord Injury, Type I DM, wound healing, endometriosis therapy, infertility, and even Muscular Dystrophy. Is there a miracle med in menses? Listen in for details.

Three Shelby County commissioners who supported a no-confidence vote aimed at Memphis-Shelby County Schools board members talked on “Behind The Headlines” about the ongoing standoff between the school board and its superintendent. 

BUFFALO, NY- January 14, 2025 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 22 on November 26, 2024, entitled “When do the pathological signs become evident? Study of human mesenchymal stem cells in MDPL syndrome.” Researchers from the University of Rome Tor Vergata, Fondazione Policlinico Tor Vergata, Roma Tre University, and Meyer Children's Hospital IRCCS have identified early cellular changes associated with Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy (MDPL) syndrome, a rare genetic aging disorder caused by a mutation in the POLD1 gene. MDPL leads to fat loss, distinct facial features, and metabolic disturbances. This study aimed to better understand how MDPL progresses at the cellular level. MDPL syndrome is extremely rare, with only a few documented cases worldwide, making it difficult to study. To investigate the disease, researchers Spitalieri Paola, Guerrieri Lara, Murdocca Michela, Di Cesare Silvia, Maccaroni Serena, Pecorari Rosalba, Nardone Anna Maria, Candi Eleonora, Colasuonno Fiorella, Gori Giulia, Traficante Giovanna, Novelli Giuseppe, and Sangiuolo Federica, converted skin cells from three female MDPL patients and two healthy donors into human induced pluripotent stem cells (hiPSCs). These hiPSCs were then transformed into mesenchymal stem cells (MSCs), cells that can form tissues like bone and fat, which are primarily affected in MDPL syndrome. The study revealed that MSCs from MDPL patients exhibited signs of premature aging much earlier than expected. The cells had irregular shapes, grew at a slower rate, and showed higher levels of cellular stress. “These cells differentiate with lower efficiency, proliferate more slowly and have abnormal mitochondrial activity with increased production of ROS. Furthermore, the telomeres show evident shortening.” All the findings suggest that aging-related changes may occur long before patients display visible symptoms of the disease. This highlights the need for early diagnosis and intervention, which could delay or even prevent the most debilitating effects of MDPL syndrome. In summary, this study offers new perspectives on the initial cellular impacts of MDPL, opening the door for the creation of novel treatments. The findings highlight the potential for personalized therapies and emphasize the critical role of lab-created hiPSCs in advancing research on rare genetic diseases and age-related conditions. DOI - https://doi.org/10.18632/aging.206159 Corresponding author - Sangiuolo Federica - sangiuolo@med.uniroma2.it Video short - https://www.youtube.com/watch?v=DLXD2ztPTm0 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206159 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, MDPL syndrome, MSCs, hiPSCs, POLD1 gene About Aging-US The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.) Please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Episode Notes My guests include prominent employment attorney Alan Crone who is representing Dr. Marie Feagins in her case against being terminated by the MSCS board. He explains why he feels the case against her is not supported by fact. Next, MSCS Board Member Amber Huett-Garcia joins me to discuss the termination effort by some of her colleagues against the Superintendent. She disagrees with that and tells me about a proposal she has drafted that she hopes will turn down the temperature on both sides. Finally, many of you have noticed that several restaurants closed last year disappointing many patrons. Memphis Restaurant Association member Arturo Azcarate, owner of Curry N Jerk joins me to talk about the reasons and to tell us about some of the new spots we can expect to tickle our tastebuds. That and more both on air and online, Monday, 6pm on WYXR 91.7 FM. Also, WYXR.org, Tunein, Facebook Live, YouTube and wherever you get your podcasts. It's time to talk!

About Dr Adeel Khan, MD - CEO and Founder of Eterna Health Interventional Cell and GeneTherapy Specialist: Dr. Adeel Khan, MD, is a trailblazer in regenerative medicine, transforming how we think about health, longevity, and recovery. As a Canadian Board-Certified Physician, Dr. Khan has pioneered cutting-edge therapies using stem cells and peptides—modalities now making headlines around the globe. Recognized worldwide, Dr. Khan's impact resonates among healthcare professionals, elite athletes, and individuals from diverse walks of life. His groundbreaking treatments have earned him the trust of renowned figures, including celebrities, such as Chris Hemsworth, life coach Tony Robbins, Chris Bumstead (popularly known as “cbum,” a top fitness influencer), and Mohamed Alabbar, the visionary developer behind the iconic Burj Khalifa. Dr. Khan's work is being discussed across major media outlets, with a focus on the potential of stem cell therapies to redefine healthcare. His ability to deliver real results is changing the conversation on what's possible in modern medicine. Dr. Khan's unwavering dedication to understanding cellular physiology and the art of cellular repair has led to collaborations with scientists in Canada, the USA, Mexico, Dubai, Italy, and Japan. These partnerships have helped shape Eterna Health, a revolutionary concept in specialized healthcare offering unparalleled treatment options that stand out in the medical landscape. Connect with Dr. Khan: Website: Eterna Health Instagram: @dr.akhan YouTube: Doctor Adeel Episode Summary: In this episode, Dr. Cassie Smith hosts Dr. Adeel Khan, a Canadian board-certified physician specializing in regenerative medicine, to discuss stem cells. Dr. Khan explains the unique properties of stem cells, particularly mesenchymal stem cells (MSCs), and their potential to treat chronic diseases, aging, and cosmetic issues. The conversation covers the science behind stem cells, their therapeutic applications, and the limitations of conventional medicine. Dr. Khan also addresses ethical concerns, regulatory challenges, and the future of stem cell research, emphasizing the transformative potential of regenerative medicine. Show Highlights: (00:02:35) Frustration with Conventional Medicine (00:04:46) Understanding Stem Cells (00:05:49) The Role of Stem Cells in Healing (00:06:27) Stem Cells and Aging (00:11:34) Clinical Applications of Stem Cells (00:14:54) Common Uses for Stem Cell Treatments (00:16:13) Stem Cells are Transforming Cosmetic Procedures (00:18:36) Stem Cells are the Body's Super Repairman (00:19:00) Smart Stem Cells?? They're Amazing! (00:20:52) Unbelievable Patient Results with Stem Cells (00:24:39) Stem Cells for Healing Autoimmune Conditions (00:29:30) FDA Regulations on Stem Cells (00:39:02) Potential of Stem Cells in Healing (00:46:24) Can Stem Cells Render Transplants Obsolete? (00:52:04) Future of Medicine with Stem Cells Connect with Modern Endocrine: Check out the⁠⁠⁠⁠⁠⁠⁠ ⁠website⁠⁠⁠⁠⁠⁠⁠⁠ Follow Cassie on⁠⁠⁠⁠⁠⁠⁠ ⁠Instagram⁠⁠⁠⁠⁠⁠⁠⁠ Follow Cassie on⁠⁠⁠⁠⁠⁠⁠ ⁠Facebook⁠⁠⁠⁠⁠⁠⁠⁠ Follow Cassie on⁠⁠⁠⁠⁠⁠⁠ ⁠YouTube⁠⁠⁠⁠⁠⁠⁠⁠ Follow Cassie on⁠⁠⁠⁠⁠⁠⁠ ⁠TikTok⁠⁠⁠⁠⁠⁠⁠⁠ Sign up for Modern Endocrine's⁠⁠⁠⁠⁠⁠⁠ ⁠newsletter⁠⁠⁠⁠⁠⁠⁠⁠ ⁠⁠⁠⁠⁠⁠⁠⁠Disclaimer ⁠⁠⁠⁠

Send us a textIn the second part of our conversation with Andrea Gough, Senior Director for Advanced Instruments' Solentim Portfolio, we'll explore how AI and machine learning have, in recent years, begun to transform various aspects of biotechnology, including cell line development (CLD). Andrea shares insights into how these cutting-edge technologies are being applied to the early stages of clone selection.AI's capability to analyze images and classify clone viability is another breakthrough. Feeding thousands of images into AI systems allows for efficient and accurate decision-making, reducing the workload on scientists.Here are three key takeaways from our conversation:Leverage AI and Machine Learning: Integrate AI to streamline clone selection and optimize cell line development processes. AI can identify key phenotypic identifiers and predict the best clones, driving efficiency and productivity.Diversify Expression Systems: While CHO cells dominate the protein therapy space, exploring alternative systems like HEK cells, MSCs, IPSCs, and even insect cells can offer unique benefits and improve gene therapy productions.Maintain Comprehensive Documentation: Ensure rigorous tracking and documentation of all processes. From certificates of analysis to raw image data, having meticulous records will safeguard your development process and aid compliance with regulatory standards.Tune in to the full episode for more insights on overcoming challenges in cell line development and tips for setting up successful bioprocessing workflows!Connect with Andrea GoughLinkedIn: www.linkedin.com/in/andrea-gough-72915282Advanced Instruments: www.aicompanies.comNext Steps:Wondering how to develop cell and gene therapies with peace of mind? Schedule your free assessment to propel your success: https://bruehlmann-consulting.com/assessmentDevelop biologics better, faster, at a fraction of the cost with our Fractional CTO services. Curious? DM us at hello@bruehlmann-consulting.com

Donald Trump said on Tuesday that he would not rule out the use of military force to seize control of Greenland. Predictably, the media ran with the twist that Trump could invade Greenland and take it from the Danish. Also on the show, Dr. Marie Feagins has stood up to the MSCS board by declaring she will not resign her position. We also play Impossible Memphis Trivia, and boy was it impossible today. See omnystudio.com/listener for privacy information.

Violent crime and efforts to battle it were among the top stories of the year as discussed in a reporters' roundtable on “Behind The Headlines.” The show also included discussion of the effort by some MSCS board members to fire school superintendent Marie Feagins and the ouster attempt by state leaders against District Attorney General Steve Mulroy.

Superintendent Dr. Marie Feagins continues to be on the hot seat as the MSCS Board still want her out. Well Memphians were not happy with MSCS trying to kick her out, and they made sure they knew about their support for the Superintendent. Also on the show, we give you our thoughts on the Tigers winning their bowl game against West Virginia last night, and we talk about our favorite toys we got for Christmas and we take our listener's favorites as well. See omnystudio.com/listener for privacy information.

Dr. Herbert Karpatkin, PT, DSc, NCS, GCS, MSCS, joins J.J. Mowder-Tinney to share his expertise on improving mobility in patients with multiple sclerosis (MS). Herb discusses the common misconceptions about MS in physical therapy and offers practical strategies, including interval training and task-specific exercises, to enhance patient outcomes. Learning Objectives Interpret the evidence around how to improve mobility and exercise tolerance in people with MS Apply evidence-based, practical strategies to actionably address fatigue to increase exercise intensity for people with MS Solve patient case scenarios involving MS focusing on exercise, rest, and functional outcomes Timestamps (00:00:00) Welcome (00:00:58) Introduction to guest (00:03:33) Is there anything we should be questioning as clinicians in regard to people with MS? (00:08:05) What's the evidence and application? (00:16:50) Translating research into clinical practice (00:26:21) Fatigue measures and scales (00:36:21) Three actionable takeaways (00:45:00) Final words of wisdom Neuro Navigators is brought to you by Medbridge. If you'd like to earn continuing education credit for listening to this episode and access bonus takeaway handouts, log in to your Medbridge account and navigate to the course where you'll find accreditation details. If applicable, complete the post-course assessment and survey to be eligible for credit. The takeaway handout on Medbridge gives you the key points mentioned in this episode, along with additional resources you can implement into your practice right away. To hear more episodes of Neuro Navigators, visit https://www.medbridge.com/neuro-navigators If you'd like to subscribe to Medbridge, visit https://www.medbridge.com/pricing/

In this episode of Unreasonable Health, Regan Archibald dives deep into the power of rejuvenation therapy and how it can enhance vitality. He explains the importance of maintaining an optimal internal environment for MSCs to thrive, and discusses groundbreaking advances in stem cell rejuvenation. Regan shares personal experiences with this powerhouse alternative, offering insights on improving joint health, brain injuries, and reducing inflammation. Tune in to learn about optimizing your body's repair processes and take on this week's health challenge—eliminate alcohol to support stem cell function.

BUFFALO, NY - December 3, 2024 – A new #review was #published in Oncotarget's Volume 15 on November 22, 2024, entitled “Mesenchymal stem cells - the secret agents of cancer immunotherapy: Promises, challenges, and surprising twists." Authored by Theia Minev, Shani Balbuena, Jaya Mini Gill, Francesco M. Marincola, Santosh Kesari, and Feng Lin from CureScience Institute, Sonata Therapeutics, and Pacific Neuroscience Institute and Providence Saint John's Health Center, this review explores the potential role of mesenchymal stem cells (MSCs) in cancer treatment. These stem cells can naturally target tumors and deliver therapeutic agents directly to cancer cells, potentially improving treatment outcomes while reducing side effects commonly associated with traditional therapies like chemotherapy. However, the authors also note significant challenges, pointing out that under certain conditions, MSCs may unintentionally promote tumor growth, highlighting the need for careful therapeutic design. MSCs are cells that can develop in different types of tissues, such as bone, fat, or cartilage, and act as natural repair agents. What makes them particularly special is their ability to respond to biological signals, like inflammation, which is often present in cancer. This enables them to locate tumors, and once there, they can deliver cancer treatments directly to the affected area. Clinical trials are already investigating MSC-based treatments for cancers such as brain tumors, melanoma, and ovarian cancer. Some results are promising, showing that MSCs can effectively deliver treatments and boost the immune system's fight against cancer. However, other trials have also revealed the complexities of MSC behavior, including variability in their effects and the potential to create conditions that support tumor growth. “This variability may be due to the tumor immune microenvironment's effects, where immune cells are inhibited by various factors, creating a conducive environment for tumor growth.” The authors also suggest that “Developing personalized MSC therapies tailored to the specific characteristics of a patient's tumor and immune system could enhance the efficacy and safety of MSC-based treatments.” Achieving this requires a deeper understanding of how MSCs interact with cancer cells and their surrounding environment. In conclusion, this review highlights both the potential and challenges of (MSCs in cancer therapy. With ongoing research and technological advancements, MSCs could become a key component of personalized cancer treatments, offering new hope for patients worldwide. DOI - https://doi.org/10.18632/oncotarget.28672 Correspondence to - Feng Lin - flin@curescience.org Video short - https://www.youtube.com/watch?v=Wwc3zDDitlc Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/ About Oncotarget Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science. Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science). To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us: Facebook - https://www.facebook.com/Oncotarget/ X - https://twitter.com/oncotarget Instagram - https://www.instagram.com/oncotargetjrnl/ YouTube - https://www.youtube.com/@OncotargetJournal LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh MEDIA@IMPACTJOURNALS.COM

In this episode of the Beautifully Broken podcast, host Freddie Kimmel speaks with Dr. Mattias Bernow, CEO of CellCollabs, about the potential of mesenchymal stem cells (MSCs) in regenerative medicine. They discuss how these cells combat chronic diseases, promote longevity, and why Good Manufacturing Practices (GMP) are crucial for safety and efficacy. Dr. Bernow shares insights into cardiovascular disease prevention trials, the importance of clinical research, and the decline in stem cell potency with age.The episode also examines the risks of medical tourism for stem cell treatments and highlights CellCollabs' mission to make therapies safer and more affordable globally. Dr. Bernow emphasizes the impact of lifestyle factors on health and the need to democratize access to quality stem cell treatments. With practical insights and key takeaways, this discussion sheds light on the future of healthcare and the value of investing in well-being.HIGHLIGHTSChapters00:00 Unlocking the Power of Stem Cells03:57 Understanding Stem Cells and Their Role in Healing10:01 The Science Behind Mesenchymal Stem Cells18:02 Safety and Efficacy of Stem Cell Therapies24:03 The Future of Stem Cell Therapy and Accessibility26:50 Innovations in Clinical Trials and Longevity Research30:28 The Role of Patient-Funded Trials in Advancing Medicine33:45 Lifestyle Factors Complementing Stem Cell Therapy37:58 The Importance of Community and Health Practices41:21 Understanding the Cost and Value of Stem Cell Treatments46:05 The Future of Health Investments and Corporate WellnessConnect with CellColabs: https://cellcolabs.comUPGRADE YOUR WELLNESSStemRegen: https://www.stemregen.co/products/stemregen?_ef_transaction_id=&oid=1&affid=52Code: beautifullybrokenLightPathLED https://lightpathled.pxf.io/c/3438432/2059835/25794Code: beautifullybrokenSilver Biotics Wound Healing Gel: https://bit.ly/3JnxyDDCode: BEAUTIFULLYBROKEN CONNECT WITH FREDDIE Check out my website and store: (http://www.beautifullybroken.world) Instagram: (https://www.instagram.com/beautifullybroken.world/) YouTube: (https://www.youtube.com/@BeautifullyBrokenWorld)

Have you heard some things about working with people with MS that make you question how to approach their care? Are they old school thoughts or based on science? Who can tell?! You'll know after listening to this episode! Hosts Erin Gallardo and Claire McLean had the privilege of speaking with Herb Karpatkin, PT, DSc, NCS, MSCS, a leading expert in physical therapy for individuals with multiple sclerosis (MS). Herb shared invaluable insights from his decades of clinical experience and research, providing guidance for physical therapists on how to actually  support patients with this complex neurological condition so they improve. A key focus of Herb's research has been exploring ways to help MS patients overcome debilitating fatigue, which often limits their ability to participate in rehabilitation. He has found great success with intermittent training protocols, where patients alternate short bursts of activity with rest periods. Herb shares specific parameters from the research so you can use it now. Next you must recognize that a significant portion of disability in MS patients may be due to deconditioning, rather than the neurological disease process itself. By implementing targeted reconditioning programs, physical therapists can make a substantial impact on improving functional mobility, even in those with advanced disease. Herb's research has also demonstrated the benefits of high-intensity interval training for individuals with MS. Contrary to outdated beliefs, many MS patients are able to tolerate and thrive with aggressive exercise programs when implemented thoughtfully. Herb emphasizes the importance of gradually progressing patients to higher intensities, while closely monitoring for signs of fatigue. To further support the MS community, Herb is actively involved with the Degenerative Disease Special Interest Group of the American Physical Therapy Association. This group has created a Clinician Locator Map to help patients find physical therapists with expertise in treating degenerative conditions like MS. For your patients and clients with MS: MS Cooling Products Application  Sign up for the clinician locator map: https://www.neuropt.org/special-interest-groups/degenerative-diseases/ddsig-clinician-locator-map Register for the free webinar on MS interventions you can apply immediately here! https://www.neurocollaborative.com/ms-webinar  

To address the need to characterize long COVID in children and adolescents, the National Institutes of Health funded a pediatric program in the Researching COVID to Enhance Recovery (RECOVER) Initiative. Editorialist Suchitra Rao, MBBS, MSCS, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, discusses this and more with JAMA Senior Editor Tracy A. Lieu, MD, MPH. Related Content: Uncovering Long COVID in Children Characterizing Long COVID in Children and Adolescents