Podcasts about pyrrole

As a holistic and functional psychiatrist, I see many people who are highly sensitive. Most are deep divers into information and able to connect a lot of dots. Many are gifted. Many struggle with overwhelm and low stress tolerance. Some struggled with anxiety, inner tension, or feeling “too much” for as long as they can remember. Some feel different - that they don't fit in.As a holistic and functional psychiatrist with over twenty years in practice, I've worked with thousands of highly sensitive adults and children. Most are deep divers into information, able to connect a lot of dots — many are gifted. And yet many struggle with overwhelm, low stress tolerance, anxiety, or inner tension that has been there for as long as they can remember. Many feel different, like they don't quite fit in. What I've found is that sensitivity itself is rarely the problem — it's the seeming vulnerability to brain-related or physical conditions. Over the years I've found three different models to be especially useful in explaining some of the vulnerabilities and the strengths of those of us who are highly sensitive: Dr. Elaine Aron's work on the Highly Sensitive Person (HSP), the nutritional medicine concept of Pyrrole Disorder, and Dr. Sharon Meglathery's RCCX Theory. Each looks at a similar group of traits through a different lens — psychological, biochemical, and genetic, respectively.Before I start, I want to emphasize that sensitivity is not a pathology or a diagnosis. It is actually a trait that has existed across human history for a reason. My goal is not to pathologize it, but to understand it — and to offer tools to those who have these traits but who are struggling with a condition more prevalent in those with these traits. As I go through these three frameworks, the overlap will be obvious and I'll highlight what each of these has to offer that the others don't.What You'll Learn* The HSP model provides validation and a language for sensitive individuals.* Pyrrole Disorder involves an overproduction of pyrroles, leading to nutrient depletion of nutrients critical for neurotransmitter functioning.* Pyrrole Disorder is common in brain-related conditions.* RCCX Theory connects genetic vulnerabilities to sensitivity and chronic illness.* Stress amplifies the experiences of highly sensitive individuals.* Understanding these models can lead to effective treatment options.* There are meaningful paths forward for those who are highly sensitive.Chapters* 00:00 Understanding High Sensitivity* 02:26 The Highly Sensitive Person (HSP) Model* 10:23 Exploring Pyrrole Disorder* 18:18 RCCX Theory Explained* 30:11 Intersecting Models: HSP, Pyrrole Disorder & RCCX Theory* 34:40 Conclusion and Path ForwardI. THE HIGHLY SENSITIVE PERSONIn the early 1990s, psychologist Dr. Elaine Aron identified a personality trait she called Sensory Processing Sensitivity (SPS) — and the people who score high in it she called Highly Sensitive Persons, or HSPs.This is not a diagnosis. It is a trait, present in roughly 15–20% of the population. It has been found across more than 100 species — from fruit flies to primates. This tells us it is evolutionarily conserved — it confers survival advantages. In any social group, having members who are wired to notice subtle cues, process information deeply, and detect threats before others do is extremely valuable. Fitting with this, many of these individuals, who also struggle with complex chronic health issues are considered the “canaries in the coal mine” since their bodies react to environmental triggers (environmental toxins, chemicals, or stressors) long before the rest of the population.Dr. Aron captured the core features of this trait in an acronym she called DOES:D — Depth of processing: HSPs think deeply, reflect before acting, and notice subtleties that others miss.O — Overstimulation: Because they process so thoroughly, HSPs reach their threshold more quickly in high-stimulation environments.E — Emotional reactivity and Empathy: HSPs feel emotions intensely and are highly attuned to the emotions of those around them.S — Sensitivity to subtle stimuli: They pick up on things — in their environment, in social dynamics, in the body — that others simply don't register.As you can see, traits that are super powers, can become liabilities. The deep diver who loses sight of the big picture. The empath who absorbs everyone else's energy as their own energy becomes depleted. The person who withdraws from the world because the stimulation has simply become too much.HSP ResearchBeyond the clinical observations, there is now a growing body of neuroscience and genetic research supporting this trait. There is evidence that the brains of sensitive people are doing more, processing more and feeling more.fMRI studies (Acevedo, Aron et al., 2014) have shown that when HSPs view emotional images — particularly photos of loved ones expressing happiness or sadness — their brains show significantly greater activation in regions associated with awareness, empathy, and sensory integration.Twin studies show that Sensory Processing Sensitivity (SPS) as defined by Dr. Aron is approximately 47% heritable. Small studies as opposed to large genome wide studies have focused on genetic variants involving dopamine and serotonin systems, such as a serotonin transport gene, a dopamine receptor gene, and COMT, which codes for the enzyme that metabolizes dopamine and norepinephrine.While this hints at a biochemical dimension, the HSP framework doesn't address this as directly as the other two models I'll discuss, nor does it explain the higher prevalence of physical health conditions in those who are highly sensitive.Research published in 2026 (Matsuzawa et al.) found that individuals high in SPS had substantially higher rates of depression (13.8%), anxiety disorder (10.5%), and developmental disorders, such as ADHD and ASD, compared to the general population.Despite this overlap with developmental disorders: unlike, ADHD, HSPs typically have excellent concentration in quiet environments. And unlike the social deficits described in ASD, HSPs tend to have heightened social attunement. They often feel too much of what's happening in social situations, not too little, even if they respond awkwardly at times.Research shows that high sensory processing sensitivity is associated with more frequent physical symptoms — back pain, fatigue, digestive issues, frequent illness.What This Framework OffersThe HSP model has given millions of people validation and a language for these traits that has allowed them to shift from “what is wrong with me” to “this is how I am wired.”It also offers an evolutionary reframe. High sensitivity is not a mistake and is not pathologic. It is a feature of the human population that has served us.What it doesn't offer is a biological explanation for why some sensitive people suffer so acutely — or a path toward biochemical intervention. II. PYRROLE DISORDERPyrrole disorder is a biochemical imbalance that has been recognized for decades, though it remains largely unknown in mainstream psychiatry. It involves an overproduction of pyrroles — metabolic byproducts that, on their own, are not a problem. When they are high, however, they can result in a depletion of zinc, B6 and a few other nutrients.First identified in the 1950s and first treated with zinc and B6 in the 1980s, pyrrole disorder is one of the most common nutrient imbalances found in brain-related conditions — and one of the most treatable. Yet most people who have it have never heard of it. I learned about pyrroles in 2014 when I first trained with the Walsh Research Institute.The Importance of Zinc, B6 & MagnesiumVitamin B6 is required to synthesize dopamine, serotonin, and GABA — three of the most critical neurotransmitters for mood regulation, anxiety, and stress response. Zinc plays a profound role in the central nervous system, the immune system, gastrointestinal tract (which we now know has its own significant influence on brain health) and connective tissue (joints and skin).Pyrrole Disorder Traits & SymptomsThe most consistent feature is low stress tolerance. People with elevated pyrroles are often described as those for whom life seems harder than it should be, every transition can be destabilizing and every large group or new environment feels like too much.The overlap with the HSP profile is striking, but here, we start to see not only traits, but symptoms.- Socially anxious, shy, or fearful since childhood, with severe inner tension- Sensitive to bright light, loud noises, textures, and odors- Avoids crowds, strangers, and new situations- History of reading difficulty- Poor short-term memory- Underachievement- Irritability, mood swings, bouts of depression- Tends to stay up late; little or no dream recall; morning nausea- White spots on fingernails; very dry skin; stretch marks; poor wound healing- Joint pain- Frequent infections or autoimmune tendenciesMost people with pyrrole disorder don't have all of these symptoms — but the inner tension, the high sensitivity, and low stress intolerance are very common.What the Data ShowsThe Walsh Research Institute has collected data on over 30,000 patients. Elevated pyrroles were found in:* 18% of those with ADHD* 24% of those with depression* 28% of those with behavioral disorders* 35% of those with autism* 35% of those with bipolar disorder* 30% of those with schizophrenia* 12% of those with PTSDAnd in only 8% of healthy controls — meaning those with no psychiatric diagnosis.What Causes Pyrrole Disorder?For many, there appears to be a genetic component, but for others, pyrroles appear to have increased due to high physiologic or emotional stress. Examples include candida overgrowth or other forms of gut microbial imbalances, mold toxicity, heavy metals, chemical exposures, illness, emotional trauma, major life transitions or even growth spurts in children.What This Framework Brings UsRelative to the HSP framework, an understanding of pyrroles gives a specific, treatable biological mechanism. When zinc, B6, Magnesium and other nutrients are depleted, we know how the brain's neurotransmitter functioning is affected — and we know what to do about it.Treatment from a Walsh Research Institute trained practitioner typically involves a nutrient protocol of zinc (based on zinc and copper testing), B6 or its active form P5P, and other nutrients for pyrrole disorder and other nutrient imbalances identified. For many patients, a lifetime of chronic inner tension and fearfulness begins to shift within days to a couple of weeks of starting the nutrients.Treatment doesn't change one's personality, but it can improve social discomfort, overwhelm, the anxiety, the depression that has been layered on top of that sensitivity.Where zinc deficiency can impact a lot of the physical conditions that appear to be more common in those who are hypersensitive, it doesn't fully explain the significant hormonal, inflammatory, connective tissue symptoms and autoimmunity we see in many who are hypersensitive.III. RCCX THEORYRCCX theory has been proposed by Dr. Sharon Meglathery, MD — a psychiatrist and internist whose own complex health history (which is very similar to my own) led her to one of the most compelling explanations I've encountered for why hypersensitivity, neurodivergence, psychiatric conditions, MCAS (Mast Cell Activation Syndrome), EDS (Ehlers Danlos Syndrome), POTS (Postural Orthostatic Tachycardia Syndrome), CIRS (Chronic Inflammatory Response Syndrome) and/or CFS (Chronic Fatigue Syndrome) and autoimmunity tend to cluster together in certain individuals and families.RCCX refers to a module of four genes on chromosome 6. Three of them appear to be particularly important to our health, and two of those have very high rates of mutation.The Three Key Genes(1) TNXB codes for a protein involved in connective tissue. Variants range from subtle joint hypermobility to Ehlers-Danlos Syndrome. But connective tissue isn't just about joints — it's also about the permeability of the gut-blood barrier, the blood-brain barrier, and vulnerability to upper cervical (neck) instability, which can put tension on the vagus nerve and affect the entire autonomic nervous system.(2) CYP21A2 is the most important gene in the module when it comes to psychiatric conditions. It codes for 21-hydroxylase, an enzyme needed to convert 17-hydroxyprogesterone into cortisol. When there is a mutation — and there can be many, of varying degrees — the body may struggle to meet the demand for cortisol under stress. A weakness on this gene could have two primary effects:First — The theory holds that many people with CYP21A2 mutations, even without hypermobility, may develop what Dr. Meglathery calls a “brain wired for danger” — essentially, a nervous system calibrated toward threat detection from early in life, with minimal trauma required. A mutation on CYP21A2 may essentially result in relatively higher androgens impacting the amygdala — the brain's fear and emotional center. Studies have found that hypermobile individuals (who often carry TNXB mutations) have a larger-than-normal amygdala.Second — because of this mutation, the body may not be able to keep up with the body's need for cortisol (especially when under stress). This deficit causes the brain to release corticotropin releasing hormone (CRH) to signal the adrenal glands to produce more cortisol. CRH binds to mast cells and activates the immune system — leading to secondary brain inflammation. This is the inflammatory pathway that can result in a number of secondary health issues including MCAS, CIRS, POTS, CFS and more.(3) C4 is involved in immune response and autoimmunity, and has been linked to schizophrenia. This gene variant is not as common as the first two referenced, though I do see a number of families who also have autoimmunity impacting multiple family members.The CAPS Psychological ProfileDr. Meglathery uses the term CAPS — CYP21A2 Mutation Associated Neuropsychiatric Spectrum — to describe the psychological profile she has observed in people with this genetic vulnerability. These traits can exist long before any formal psychiatric diagnosis, and they are not inherently pathological. - Anxiety and over-arousal during times of stress — high adrenaline, insomnia, sometimes manic-like characteristics- Under-arousal during low-stress periods — leading to ADD presentations, compulsive behaviors, or thrill-seeking to raise arousal- High emotionality, sensitivity, and reactivity to environmental stimuli- Sensory processing difficulties — typically over-stimulation in loud or chaotic environments- A strong ability to read emotions in others, paired with social awkwardness in response- Easily affected by events others would consider minor — an offhand comment, a disturbing movie- A tendency toward nonconformity- Special abilities: gifted musicians, scientists, creatives, systems thinkers- Hyper-focus and obsession with areas of deep interest, often leading to remarkable accomplishments- High tenacity and determination, when not derailed by overstimulation or past trauma- Strong emotions — positive or negative — that can manifest as obsessional worrying, harm avoidance, OCD tendencies, or very high standards for self and othersDr. Meglathery also notes — and I have observed this clinically — that people with this profile tend to find each other through friendships, partnerships and marriage. They are drawn together by shared sensitivities, emotional depth, and intellectual gifts. This means children are likely to receive a tendency towards CAPS from both sides.Women who are appear to have CYP21A2 mutations often have a male-pattern finger length ratio — the ring finger longer than the index finger — a possible marker of androgen exposure during development.What RCCX OffersRCCX theory offers the broadest biological framework we have for understanding why sensitivity, psychiatric vulnerability, and complex chronic illness so often travel together in the same people and families. It connects the nervous system, the immune system, the hormonal system, and connective tissue under one genetic umbrella.It also points toward specific interventions: nervous system regulation (limbic retraining, vagal work), mast cell management, and addressing the downstream biochemical consequences of cortisol dysregulation.The limitation is that genetic testing for variants on the gene for 21-hydroxylase is not yet widely available, which is why this isn't a gene that you'll see referenced when it comes to HSP, though I would argue it is likely the most prevalent. RCCX remains a clinical theory — but one that explains the constellation of traits and symptoms of most of the people that I in my practiceIV. WHERE THESE MODELS INTERSECTWhere Might Pyrrole Disorder and RCCX Theory Meet?The symptom overlap is almost complete: poor stress tolerance, sensory sensitivities, anxiety, inner tension, connective tissue symptoms, frequent infections, autoimmune tendencies. Relatively low zinc would impact most of these shared symptoms, but there may be a potentially deeper connection.21-hydroxylase contains a pyrrole-like structure — heme — within it. Could a mutation resulting in abnormal 21-hydroxylase lead to a buildup of abnormal heme-like compounds, contributing directly to pyrrole disorder? This is not proven, but in an exchange about this with Dr. Meglathery, she indicated that she also believes there is a strong association, and the biochemical logic is compelling.This matters, because we know what helps pyrrole disorder. We have a treatment — treatment that can complement what RCCX theory makes evident — that the stress response has to be addressed.Stress (again from any cause - physiologic or emotional) is the great amplifier across all three models. Stress worsens the HSP experience, and tips the CYP21A2 mutation from manageable to destabilizing (through the hormonal consequences and the inflammatory cascade) and yes, it even causes pyrroles to increase.BRINGING IT TOGETHERFor someone who is highly sensitive, and struggling with brain related or physical symptoms or conditions, pyrrole disorder and even RCCX theory are worth considering because they offer tools and start to answer, “What Can We Do About It?”The three frameworks work together:The HSP model offers validation and language. It shifts the frame from deficit to difference. It reminds us that sensitivity is not pathology — it is a trait with evolutionary value, and it comes with great strengths.The Pyrrole model offers a treatable nutrient imbalance. It explains, at the neurotransmitter level, why stress hits harder for these individuals. Treatment doesn't take away the sensitivity; it lifts the weight that has accumulated on top of it.The RCCX model offers the broadest systems view. It connects the dots between what the body is doing — the immune activation, the hormonal dysregulation, the connective tissue involvement — and the psychiatric and psychological profile that tends to accompany it. It also provides additional tools: nervous system regulation, mast cell support, hormonal awareness.If any of this resonates — the sensitivity, the inner tension, the feeling of always being at the edge of overwhelm — please know that there are roots to explore and meaningful paths forward.If you are looking for someone trained by the Walsh Research Institute knowledgeable in assessing for and treating pyrrole disorder (and other common nutrient imbalances impacting brain health), or learning more about Dr. Aron's work on HSP and Dr. Meglathery's RCCX theory, I am providing those links below.And as always, I welcome your thoughts, experience and questions.Until next time,CourtneyAbout the AuthorDr. Courtney Snyder MD is a Holistic and Functional Child and Adult Psychiatrist who offers non-patient consultations to individuals and practitioners nationally and internationally in addition to her treatment practice serving FL, IN, KY, OH. Her educational content, shared through her website, Substack Newsletter, the Holistic Psychiatry Podcast and YouTube Channel reaches readers and listeners in over 160 countries.ResourcesWalsh Research Institute: walshinstitute.orgRCCX Theory — Dr. Sharon Meglathery: rccxandillness.comDr. Elaine Aron — The Highly Sensitive Person: hsperson.comOther Sources: Acevedo et al. 2014, “The Highly Sensitive Brain,” Brain & Behavior | Matsuzawa et al. 2026, Psychiatry & Clinical Neurosciences ReportsMedical Disclaimer:This newsletter is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment for either yourself or others, including but not limited to patients that you are treating (if you are a practitioner). Consult your physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

In this episode, I dive deep into the often-overlooked biochemical condition known as pyrrole disorder. You'll learn how pyrroles, nutrient depletion, and vagus nerve dysfunction can impact emotional regulation, stress resilience, and overall well-being. I break down the science behind heme and hemoglobin, then connect the dots between emotional symptoms and key nutrients like vitamin B6 and zinc.The episode introduces the Pyrrole Disorder-Vagus Nerve Connection, a holistic approach that includes validation, activation, gut-brain-immune optimization, unburdening stressors, and sustaining mindful habits. Real-life examples and actionable strategies help make the information relatable and empowering, showing how you can address both the root causes and effects of chronic stress and emotional challenges.If you're ready to break free from emotional dysregulation and improve your health at its core, now's the perfect time to take action. Check out the Emotional Resilience Upgrade program launching April 8th, and book a discovery call. Join a supportive community and take the next step toward lasting emotional freedom and resilience!Dr. Navaz HabibEmail: podcast@healthupgraded.comFacebook: https://www.facebook.com/DrNavazHabib/Instagram: https://www.instagram.com/drnavazhabib/LinkedIn: https://ca.linkedin.com/in/drnavazhabib 

Do you struggle with anxiety, depression, mood swings, or fatigue?Do you have stretch marks, thin hair or nails, or burn easily?Do you struggle with bloating, acid reflux, or constipation?Or - do you have a family history of depression, anxiety, bipolar disorder, ADD/ADHD, or autism?On today's episode, we're taking a sudden turn into a topic that few of my clients ever hear about prior coming to our office - yet it affects up to 10% of the general population. And that is - pyrrole disorder.If you've never heard of pyrrole disorder before - you're in for a treat! On today's episode, I'm breaking down what pyrrole disorder is, pyrrole disorder symptoms, who gets it, how you can have symptoms of pyrrole disorder without actually having the disorder, and how to treat pyrrole disorder and manage it so you can live symptom-free.If you've been looking for better solutions to your gut health, mental health, or less-than-desirable hair, skin, and nail health - then this episode is for you.TIMESTAMPS:00:00 - Introduction to Pyrrole Disorder 00:37 - Understanding Pyrrole Disorder 07:46 - Symptoms of Pyrrole Disorder 19:16 - Testing for Pyrrole Disorder 29:17 - Treatment and Management 31:17 - Conclusion and ResourcesWORK WITH ME:Option #1)

Do you struggle with anxiety, depression, mood swings, or fatigue?Do you have stretch marks, thin hair or nails, or burn easily?Do you struggle with bloating, acid reflux, or constipation?Or - do you have a family history of depression, anxiety, bipolar disorder, ADD/ADHD, or autism?On today's episode, we're taking a sudden turn into a topic that few of my clients ever hear about prior coming to our office - yet it affects up to 10% of the general population. And that is - pyrrole disorder.If you've never heard of pyrrole disorder before - you're in for a treat! On today's episode, I'm breaking down what pyrrole disorder is, pyrrole disorder symptoms, who gets it, how you can have symptoms of pyrrole disorder without actually having the disorder, and how to treat pyrrole disorder and manage it so you can live symptom-free.If you've been looking for better solutions to your gut health, mental health, or less-than-desirable hair, skin, and nail health - then this episode is for you.TIMESTAMPS:00:00 - Introduction to Pyrrole Disorder 00:37 - Understanding Pyrrole Disorder 07:46 - Symptoms of Pyrrole Disorder 19:16 - Testing for Pyrrole Disorder 29:17 - Treatment and Management 31:17 - Conclusion and ResourcesWORK WITH ME:Option #1)

I recently had the pleasure of being on the Nourished By Nature: Mind Body Wellness Podcast with Annika Taylor, a holistic health practitioner. After sharing with Annika how I became a holistic psychiatrist and how I define holistic psychiatry, we discuss:* The Walsh Research Institute's data on nutrient levels of 30,000 people with brain-related symptoms, and what were found to be the most common imbalances (One or more of these imbalances is present in about 90-95% of the patient's that I evaluate for brain-related symptoms).* The Walsh biotypes of depression. How I test for the copper-zinc imbalances, pyrrole disorder, and methylation imbalances.* High copper and its relationship to ADHD, anxiety, depression and post-partum. depression, anxiety and psychosis.* Pyrrole disorder - symptoms, traits and treatment.* How methylation impacts brain health.* Under and over-methylation symptoms and traits.* Treatment of under-methylation.* How this understanding can remove the stigma associated with mental health conditions, and provide healing and hope.In recent years, Dr. Walsh discovered that undermethylation is increasing in the population while overmethylation is decreasing.If you'd like to add to the discussion, I always appreciate your questions and comments.Have a great week,CourtneyRelated Resources:Annika Taylor - nourishedbynature.comWalsh Research InstituteFor links to specific topics address see links in the description above. Medical Disclaimer:This newsletter is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis, or treatment for yourself or others, including but not limited to patients you are treating (if you are a practitioner). Consult your physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

Anxiety, depression, and other mental distress can be caused by pyrrole disorder (aka pyroluria). How can this loss of zinc, Vitamin B6, and other nutrients be identified and treated? “He suddenly developed anxiety, intrusive thoughts and images…[of] brutal things happening to his parents,” says Dr. Jingduan Yang MD, describing his then 9-year-old patient, who also suffered insomnia, restlessness, and low attention span. A simple urine test of the boy confirmed much higher than normal kryptopyrrole in his system – a problem Dr. Yang sees in 50 to 70 percent of his patients; often severely impacting their mental health. Dr. Yang is a psychiatrist and integrative medicine doctor who combines western medicine and holistic medicine, including acupuncture and advanced nutrient therapy in his practice. “People come in with all kinds of diagnoses–bipolar disorder, major depression, ADHD, borderline personality disorder, schizophrenia, schizoaffective [disorder], and all kinds of things,” he says. “But nobody…[asked if] there was an underlying biochemical imbalance contributing to a critical nutritional deficiency, he adds.” Dr. Yang joins Vital Signs with Brendon Fallon to highlight pyrrole disorder as an overarching cause of mental disorder. What signs would alert parents to pyrrole disorder in their children? And where does the 9-year-old treated with advanced nutrient therapy stand now, five years later?  

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In this video and podcast episode, I discuss pyrrole disorder - one of the most common nutrient imbalances in brain-related conditions affecting adults and children. Elevated Hydroxyhemopyrrolin-2-one (HPL) in the urine, often referred to as “pyrroles,” has been associated with depression, anxiety, schizophrenia, bipolar disorder, autism, ADHD, learning disorders, substance use disorders, and violent behavior. Here, I address:* How pyrrole disorder relates to other “root causes.”* What we know, what we don't know, and why this topic is controversial.* Causes.* Zinc and B6 depletion and how these impact brain health.* Brain and physical symptoms and traits.* Treatment. * How low-stress tolerance can impact one's ability to pursue meaningful education, work, and relationships.As always, I welcome your questions and comments.Have a good week,CourtneyTo learn more about this and other factors contributing to brain symptoms or to receive these newsletters in your mailbox each week, visit www.CourtneySnyderMD.comRelated Resources* Pyrrole Disorder Symptoms List* Zinc & the Brain https://courtneysnydermd.substack.com/p/zinc-and-the-brain* RCCX Theory, Hypermobility, Mental Health & Complex Chronic Illnesshttps://courtneysnydermd.substack.com/p/hypermobility-rccx-theory-mentalMedical Disclaimer:This newsletter is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis or treatment for either yourself or others, including but not limited to patients that you are treating (if you are a practitioner). Consult your own physician for any medical issues that you may be having. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit courtneysnydermd.substack.com/subscribe

This is another Ask Me Anything episode where I answer questions from you - my amazing community! This week's episode was inspired by a big question that covered so many great topics! Here's just a sneak peak of some of what we cover in this episode: Gut testing What to do if you have a Candida overgrowth and no good bacteria in your gut What to do if you have low stomach acid What to do if you aren't producing enough neurotransmitters The root cause variables behind Pyrrole disorder (pyroluria). Is it really genetic? What it really means if you are low B12 and iron Sugar addictions Does menopause make everything worse? My thoughts on what testing is worth your money and what isn't (my answer will probably surprise you!) Resources & Products mentioned in this episode: The “How to Eliminate Common Gut Pathogens That Create Anxiety” Workshop The Complete Gut Health Workshop Bundle Ep. 11 - The Real Root Causes of Anxiety [Pt.1] Ep. 15 - The Real Root Causes of Anxiety [Pt. 2] Ep. 19 - The Real Root Causes of Anxiety [Pt. 3] The Breaking Up With Anxiety Group Coaching Program The ByeBye Anxiety Bundle The “How to Reprogram Your Gut” Workshop Full Scan by CBH Energetics GI Map by Diagnostic Solutions Ep. 18 - Jess's Journey to Anxiety Freedom For more information about all the Breaking Up With Anxiety offerings or to find most links, please check out: My Website: www.taygendron.com My Instagram: @tay.gendron Main Links Page: https://www.taygendron.com/links Here are two free resources to get you started on your journey to anxiety freedom: “CALM” - Free 5 Day Mini Workshop to Soothe an Anxious Mind https://courses.taygendron.com/calm “The Three Secrets to Natural Anxiety Banishment” - free webinar training on why medication, therapy and meditation haven't been enough to banish anxiety from your life and what I recommend doing instead https://courses.taygendron.com/3secrets If you'd like to submit a question for future episodes, fill out this form https://bit.ly/ask-tay-anything in as much detail as possible. All questions will remain anonymous and you will be notified via email when your question is answered! Looking for a transcript for this episode? CLICK HERE! If for some reason (because technology is not always our friend) the links in the show notes aren't working send me a DM on Instagram or send me an email hello@taygendron.com and I will get that link to you! I hope you enjoyed this episode and I will see you in the next one!

It's not just autism parenting causing extreme stress, angry outbursts, anxiety and mood swings. It's genetic. It's biochemical, and it's something that you have in common with your autistic child. This podcast episode covers the hidden link between pyrrole disorder, zinc deficiency and copper toxicity, which cause many mental health problems for children and parents in autism families. These imbalances are more common in people of Scandinavian, Irish, and English descent (which includes many American/Canadian families as well.)Don't miss this conversation between Ninka-Bernadette Mauristson and Hilde Lorentzen about stress intolerance, anger, rage, mood swings, anxiety and panic attacks,  depression, eating disorders, addiction, night terror, gut - and blood sugar imbalances and how to deal with it from a nutritional standpoint. Here are 3 ways we can start turning autism symptoms around together, whenever you're ready... 1. Send me a voice message and get my feedback on your most pressing struggles. 2. Check out the free video series "The 5 hidden messages behind autism symptoms" and find your child's unique triggers. 3. Work with me privatelyIf you'd like to work with me directly to turn as many symptoms around as possible in my Autism Turnaround Coaching and implementation group..send me an email with "coaching" in the subject line and tell me how old your child is. I'll get you all the details.

In this podcast episode, we are chatting about quite a complex disorder called Pyrrole Disorder. It is a condition that isn't that well-known in mainstream medicine, but we are seeing more and more of it in clinical practice. Pyrrole disorder is an imbalance in the body that affects the synthesis of haemoglobin and causes the body to overproduce a substance called HPL. HPL goes on to deplete the body of crucial nutrients, primarily zinc, B6, and magnesium. We often see Pyrrole Disorder linked to conditions such as anxiety, OCD, ADHD and many mental health conditions. For this episode, I am joined by naturopath, nutritionist, and herbalist Ross Walter, who specialises in complex cases and is passionate about helping people with their health through nutrition, lifestyle advice, and the use of holistic modalities, and education.In this episode, Ross and I dive deeper into pyrrole disorder and we discuss: More about pyrrole disorder and its causes;What happens to the body of someone with Pyrrole Disorder;We discuss the symptoms and range of conditions associated with pyrrole disorder and what to look out for;How to test for pyrrole disorder, and what the tests can tell us;What the key treatment considerations are for pyrrole disorder;Plus much more. Episode Links:Check out Ross Walter's website here. Read our blog post on pyrrole disorder on the Natural Super Kids podcast here. 

Our special guest, Susan DeLaney, ND, RN, will discuss Pyrrole Disorder: what it is & how to address it. Welcome to Humanized! Each week, we feature top experts in personalized health and functional medicine through engaging interviews and presentations. You'll get practical advice on diet and nutrition, lifestyle, toxins and disease, hormone imbalances, nutrient deficiencies, inflammation, digestive health, mental health, the fast-changing world of genomics, and so much more. All presentations are available as videos, podcasts or transcripts – whichever form is most convenient and enjoyable for you! Visit us at: https://humanizedhealth.com Subscribe to get weekly updates at: https://omniform1.com/signup/v1/5e736dfb8a48f751fdd6aa8a_604bd3c799f0b7086d1de9a4.html

We're discussing metabolic health, metabolic healing, the kinship of different nutrients and minerals, and how an imbalance of certain nutrients and minerals such as copper, zinc, iron, and magnesium are at the root cause of a range of health conditions becoming prevalent in society. In pursuit of health and healing, most people, at some point in their life, have been told by a doctor or healthcare practitioner that they need to take Vitamin C, D, and Iron supplements to bring their body back into a state of harmony. At some point in their life, many women will also be told they are anaemic. In this episode, Dan breaks down how and why many people who have been diagnosed as anaemic are actually not, and how downsizing the number of synthetic supplements you take daily (a less is more approach)- could be the missing link in achieving health harmony. Dan discusses his health journey finding out he was copper anaemic, which lead him to researching the relationship between ceruloplasmin production, copper deficiency, tissue-stored iron, retinol, D3, and whole-food vitamin C. We love having Dan frequent the SuperFeast pod; his non-dogmatic approach and devotion to upgrading his knowledge in health and vitality keep us inspired and on point. In this episode, Dan delivers accessible health protocols for acute situations and lifestyle maintenance and discusses what an ancestrally aligned diet looks like, and why our bodies thrive on them.     "It turns, out a lot of the time people aren't actually low in iron. It's just that so much of their iron is stuck in the tissue, and it looks deficient in the blood. So, what do they get? They get iron supplements. Which just compounds the whole problem. It creates more oxidative stress. No one's looking at copper. If anything, they've been told they have too much copper, right? So you can see how that conundrum just accelerates and accelerates. And you end up with this more inflammatory, more oxidative stress type of picture over time, which eventually leads to chronic fatigue". - Dan Sipple     Mason and Dan discuss:   -Anaemia. -Zinc deficiency. -Copper anaemia -Pyrrole disorder. -Metabolic health. -Metabolic healing. -Ancestral nutrition. -Bioavailable copper. -Autoimmune disorders. -DHEA supplementation. -The Importance of retinol. -Hemochromatosis in men. -Terrain theory vs germ theory. -Copper deficiency symptoms. -The difference between retinol and beta carotene. -The relationship between retinol and D3 supplements. -Whole food vitamin C vs ascorbic acid and liposomal C.    Who Dan Sipple?  Dan Sipple also known as The Functional Naturopath is based on the south coast of NSW and has a special interest in gut health, immune dysfunction, pro-metabolic health, mineral rebalancing & hormones.  Dan has been in the health and wellness arena for over a decade and blends traditional herbal medicine systems and knowledge with cutting-edge functional and integrative testing to best facilitate a patient's journey to peak wellness.   Resources:   Dan Website Dan Instagram Gut Health Podcast 1 Gut Health Podcast 2 Autoimmunity and Medicinal Mushrooms (EP#18) Optimising Your Gut Bacteria with Dan Sipple (EP#68) How to Turn Your Immune System On with Dan Sipple (EP#131)   Resources mentioned in the podcast:   Truth Calkins book Matt Blackburn website Morley Robbins - Cure Your Fatigue (book) Ray Peat- Generative Energy Restoring The Wholeness of Life   Check Out The Transcript Here: https://www.superfeast.com.au/blogs/articles/dan-sipple-ep-158

In this episode I discuss Pyrrole Disorder - a common biochemical imbalance in brain disorders caused by an excessive production of HPL (a hydroxyhemopyrrolin). A hallmark of Pyrrole Disorder is poor stress intolerance. Other common symptoms can be social avoidance and/or temper outbursts. In this episode I'll answer: What are pyrrols? How does an overproduction contribute brain symptoms? What are the symptoms and traits (brain related and physical that can be seen) in adults and children? How can we become "pyrroluric"? How can I test my pyrrole level? How is Pyrrole Disorder treated? From the Walsh Research Institute of over 30,000 patients with brain disorders: ADHD - 18 % (18% of individuals diagnosed with ADHD had elevated pyrroles) Behavioral Disorders - 28 % Autism - 35% Depression - 24% Bipolar Disorder - 35% Schizophrenia - 30% Post-Traumatic Stress Disorder - 12% Alzheimer's Disease - 14% Healthy Controls (no psychiatric symptoms) - 8% ___________________________________________________ Subscribe to my newsletter (or learn more about root causes to brain symptoms)— https://www.courtneysnydermd.com Please consider rating or reviewing, liking or commenting, if you'd like to help me get this information out into the world. You can engage at: Facebook - https://www.facebook.com/courtneysnydermd/ Instagram - https://www.instagram.com/holistic_psychiatry/?hl=enI YouTube - https://www.youtube.com/channel/UC8JF5homBrN3D38OEZlzxig __________________________ Medical Disclaimer: This podcast is for educational purposes and not intended or implied to be a substitute for professional medical advice, diagnosis or treatment for either yourself or others, including but not limited to patients that you are treating (if you are a practitioner). Consult your own physician for any medical issues that you may be having.

  Anxiety, anger, and stress are a normal part of the human experience. But if you find yourself unable to tolerate even the smallest amount of stress without feeling lots of anxiety and anger, you may have a little-known stress disorder known as Pyrrole disorder. Pyrrole disorder (also called Pyroluria) occurs when a biochemical abnormality results in the overproduction of pyrrole molecules. Pyrrole molecules are excreted continuously in the urine and are normal by-products of hemoglobin synthesis and other bodily processes. For the average healthy person, this is not a problem. However, for someone with Pyrrole disorder, nutrient deficiencies occur because these molecules have an affinity for zinc and vitamin B6, causing them to latch onto and excrete them in the urine before the body can adequately absorb them, leading to severe oxidative stress. Pyrrole disorder is connected to a plethora of symptoms and disorders such as extreme anger and rage, rapid mood swings, night owl tendencies, high anxiety, depression, morning nausea, alcoholism, and bipolar disorder. Pyrrole disorder is something I regularly test for in my clinic. It is typically seen in people of all ages and is often genetically inherited in Northern European people groups such as the Irish and Scandinavian populations. In today’s episode, I take a deep dive with Dr. Judith Bowman of Mensah Medical into what this disorder is and how it may be impacting your mental and physical health as well as myths that could be potentially harmful. I hope this episode leaves you empowered and educated on this stress intolerant disorder and how focusing on root causes instead of symptoms is how true healing occurs. Listen to the full episode to hear: How Pyrrole disorder can be a root cause of alcoholism and addiction The connection between stress intolerance and Pyrrole disorder The role genetics plays in Northern European people groups Why zinc and B6 for important for optimal brain function What the differences are between omega 3 and omega 6 fatty acids The disturbing myth that manganese is required to treat Pyrrole disorder Learn more about Dr. Judith Bowman: Mensah Medical About Dr. Judith Bowman Learn more about Sami: Eatfor.life Book Your Complimentary Consultation Resources: Eat For Life EP 20: Biochemical Imbalances that Cause Eating Disorders with Dr. Judith Bowman The Pyroluria Diet, Samantha Gilbert, FNC, CHNP, CNC Nutrient Power: Heal Your Biochemistry and Heal Your Brain, William J. Walsh, PhD  

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.13.249730v1?rss=1 Authors: Finn, P. B., Bhimsaria, D., Ali, A., Eguchi, A., Ansari, A. Z., Dervan, P. B. Abstract: Regulating desired loci in the genome with sequence specific DNA binding molecules is a major goal for the development of precision medicine. Pyrrole imidazole (Py Im) polyamides are synthetic molecules that can be rationally designed to target specific DNA sequences to both disrupt and recruit transcriptional machinery. While in vitro binding has been extensively studied, in vivo effects are often difficult to predict using current models of DNA binding. Determining the impact of genomic architecture and the local chromatin landscape on polyamide DNA sequence specificity remains an unresolved question that impedes their effective deployment in vivo. In this report we identified polyamide DNA interaction sites across the entire genome, by covalently crosslinking and capturing these events in the nuclei of human LNCaP cells. This method, termed COSMIC seq, confirms the ability of hairpin polyamides, with similar architectures but differing at a single ring position, to retain in vitro specificities and display distinct genome-wide binding profiles. These results underpin the development of Py Im polyamides as DNA targeting molecules that mediate their regulatory or remedial functions at desired genomic loci. Copy rights belong to original authors. Visit the link for more info

More and more, we are seeing headlines exposing the narcissistic and criminal behavior of several high profile predators. We’ve seen a top recording artist finally be indicted after years of abusing young girls and women. We’ve seen convictions for a well-known movie mogul and long-standing comedian and actor, as well as a US Gymnastics National Team doctor—just to name a few. Unfortunately, so many people—beyond the scope of these high profile cases—have been harmed by those with narcissistic, abusive, and criminal behavior. Today on the show, I’m discussing the biochemistry of narcissism, sociopathy, and psychopathy with Dr. Albert Mensah, MD, BCIP. I’ve had Dr. Mensah on the show before, both in Episode 3 where we discussed how biochemistry and genes impact your brain, and in Episode 4 with a discussion about COVID-19 depression, anxiety, and immunity. If you’ve been harmed by narcissism and gaslighting, I hope this conversation with Dr. Mensah brings hope, healing, and an understanding of why you were harmed. Dr. Mensah is a world-renowned leader and teacher in micro molecular medicine. He is the co-founder of Mensah Medical in Warrenville, Illinois, a clinic that specializes in the treatment of biochemical imbalances and the cognitive and physical disorders caused by those imbalances. Since 2005 Dr. Mensah has treated over 30,000 patients using all-natural, non-pharmaceutical targeted nutrient therapy. His practice focuses on the management and treatment of cognitive disorders such as autism, behavior and learning disorders, eating disorders, bipolar disorder, anxiety syndromes, childhood and adult schizophrenia or Alzheimer's, and Parkinson's disease, as well as family medicine. Dr. Mensah regularly presents at international conferences, trains physicians in advanced nutrient therapy techniques, and is board certified in integrative pediatrics by the American Association of Integrative Medicine. Listen to the full episode to hear: The biochemistry of narcissism, sociopathy, psychopathy The role of epigenetics and trauma in criminal behavior How copper toxicity and deficiency, undermethylation, and Pyrrole disorder impact behavior The role parents can play in the creation of a strong family foundation How an underdeveloped amygdala cortex impacts the ability to have empathy and emotional connectivity with others Learn more about Dr. Albert Mensah: Mensah Medical Mensah Medical on Facebook   Learn more about Sami: Eatfor.life Work with me One-On-One  

Pyrrole disorder or pyroluria is believed to affect up to 10% of the population, but what clues should we be on the look out for when each case can present quite differently? Today we are joined by naturopath, Jules Galloway who takes us through her professional and personal experiences whilst managing pyrrole patients. Jules also shares her wisdom on crafting treatment plans that match the patient sitting in front of you and their unique presentation. Find today's show notes and transcript here: https://www.fxmedicine.com.au/content/navigating-pyrrole-patient-jules-galloway *****DISCLAIMER: The information provided on FX Medicine is for educational and informational purposes only. The information provided is not, nor is it intended to be, a substitute for professional advice or care. Please seek the advice of a qualified health care professional in the event something you learn here raises questions or concerns regarding your health.*****

Welcome back to our weekend Cabral HouseCall shows! This is where we answer our community's wellness, weight loss, and anti-aging questions to help people get back on track! Check out today's questions:  Elise: Hello dr Cabral! I recently discovered this podcast and I absolutely love it! The past few months I’ve been hearing more and more about people doing psychedelic mushrooms and having positive mental/spiritual effects. I have always been very sceptic to everything that effects my brain and that is out of my control, but it peaked my interest. I know they have been commonly used in rituals in many ancient cultures, especially in South America. I just wanted to get your thoughts on the matter. Do you think that it could have a positive effect? (of course it has to be organically grown and from a good source). What are the potential side effects? Thank you in advance! Rosie: Hi Dr Stephen Cabral,I am Rosie, from south -Africa-I am currently studying your IHP course level 1,2 but have a situation with my husband regarding GERD, Barrett’s esophagus and acid reflux PPI.My husband swallowed a camera and got his results back that he has Barrett’s and his dad has this done 7 months ago and had the same results. His dad had an operation done and I am trying to get my husband to not “just cut out” as the recovery is weeks of a liquid diet ect and you can never vomit again if ill... my husband is 34 and weighs 117kg he needs to lose weight, he struggles badly with leaky gut specially feels the effects of gluten with bloating and I am sure he has a bacteria overgrowth. I am putting him on your meal plan for weight loss to loose the weight first.Please could you guide us into the right direction.Do you know of Labs that can be done in South Africa? Our exchange rate is very bad and would love to run labsThanks so much, Kind regards Rosie Samantha: Hi Stephen, I love your podcasts, thank you for providing so much amazing insightful information. The rain barrel effect in one of my Favourite reads. I think it should be in every library world wide !My question is - what do you think of the Pyrrole test ? Is it important ? What sort of conditions can it pick up ? I have had anxiety and depression /mood swings for many many years. Going back to my teenage years , which was over 20 years ago. A friend suggested it might be worth me having the Pyrrole test. Thank you and can't wait to hear your thoughts Kelly: Hi Dr. Cabral! What advice do you have for individuals with lipedema? I struggled to lose weight in my heavy thighs/bottom half for decades- eating extremely cleanly, starving myself, severely restricting calories, and eventually resorting to bulimia because of my extreme pear shaped body. Then, I discovered there is a condition called lipedema that makes it impossible to lose fat in these regions. Apparently, the only reliable "treatment" is liposuction. Please help! Kristen: Hi Dr Cabral. Reading your book and listening to your podcasts has really helped me understand a lot of my health dis-eases. One problem that I have been facing is heavy legs. It all started after an intense SIBO & parasite protocol and I believe my detox pathways were not well supported. I began to gain weight after a stressful time. That winter I had horrible depression, fatigue (only 2,000 a day) really cold, and could hardly climb stairs. My thought is that my lymphatic system started to get clogged. I have brain fog and developing varicose veins, but i also have all sorts of gut infections and mold toxicity. Someone told me it could be from hormone imbalances (have that too) or else from the mold. My thyroid is optimal now from medication, but still have the heavy legs. what could it be from, and what could i do? Thanks! Matt: Hi Dr.Cabral, I'm writing in for about my friend's condition. He's not into alternative medicine and a holistic approach to health yet so I was hoping you could shed light on a starting point for his illness. He has pus filled bumps on the back of his head. Some as large as a nickel and they don't seem to come to head like an average face pimple. From a far it looks like he's balding with little patches all over his head but really they are these pus filled bumps. He is currently taking accutane with results on body and face acne but not for his head condition. Any thoughts on what might be causing this or what tests should be done to find the root cause Lawson: Hey Dr. Cabral. This is the best podcast ever. Quick question. Many of my peers, coworkers, family, online strangers tend to complain about knee and back pains when they're approaching the age of 30. Some were never involved in sport or got injured. They just feel pain. Is that part of the so-called aging process? I am 34 years old suffered injuries from sport, but I am currently without any pain or joint issue. Is there anything I can do from your expertise to avoid the niggling pains they're going through or is it inevitable? Is there anything I can recommend to them to alleviate their plight? Keep up great work Darron: Hey Dr. Cabral. Are there any drawbacks from using the supplements l arginine, l-citrulline and beta alanine for training purposes? Also are there benefits to using them for persons who don't train but are otherwise active like my dad who's 61. Keep up great work Doc   Thank you for tuning into today's Cabral HouseCall and be sure to check back tomorrow where we answer more of our community’s questions!  - - - Show Notes & Resources: http://StephenCabral.com/1317 - - - Get Your Question Answered: http://StephenCabral.com/askcabral   - - - Dr. Cabral's New Book, The Rain Barrel Effect https://amzn.to/2H0W7Ge - - - Join the Community & Get Your Questions Answered: http://CabralSupportGroup.com - - -   Dr. Cabral’s Most Popular Supplements: > “The Dr. Cabral Daily Protocol” (This is what Dr. Cabral does every day!) - - - > Dr. Cabral Detox  (The fastest way to get well, lose weight, and feel great!) - - - > Daily Nutritional Support Shake  (#1 “All-in-One recommendation in my practice) - - - > Daily Fruit & Vegetables Blend  (22 organic fruit & vegetables “greens powder”) - - - > CBD Oil  (Full-spectrum, 3rd part-tested & organically grown) - - - > Candida/Bacterial Overgrowth, Leaky Gut, Parasite & Speciality Supplement Packages - - - > See All Supplements: https://equilibriumnutrition.com/collections/supplements  - - -   Dr. Cabral’s Most Popular At-Home Lab Tests: > Hair Tissue Mineral Analysis (Test for mineral imbalances & heavy metal toxicity) - - - > Organic Acids Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Thyroid + Adrenal + Hormone Test  (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Adrenal + Hormone Test (Run your adrenal & hormone levels) - - - > Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Omega-3 Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - > Stool Test (Use this test to uncover any bacterial, h. Pylori, or parasite overgrowth) - - - > Genetic Test (Use the #1 lab test to unlocking your DNA and what it means in terms of wellness, weight loss & anti-aging) - - - > Dr. Cabral’s “Big 5” Lab Tests (This package includes the 5 labs Dr. Cabral recommends all people run in his private practice) - - - > View all Functional Medicine lab tests (View all Functional Medicine lab tests you can do right at home for you and your family!)

Naturopath Peter Mullen discusses a condition that usually displays as a mental health issue, poor ability to handle stress, or immune and metabolic issues

In a few words, this disorder is an acute stress intolerance affecting more and more hard-working people. It is still unknown to most doctors and alternative medicine professionals, yet more and more people show up with this acute stress-induced (or genetic) disorder which causes high anxiety, mood swings, obsessive behavior, hyperactivity, sensitivity to light, sensitivity to sound, poor healing and slow recovery. Why? In this podcast you will learn to look for signs of Pyrrole Disorder, who has it, and why are victims so misunderstood and mistreated when the issue is basically a lack of certain nutrients?This is a must for people who struggle with moods, anger, aggression, addiction, ADHD, OCD, pain, autism, oxidative stress and anyone with Irish, English or Scandinavian genes. Episode Notes: Watch my Interview with the leading expert on Pyrrole Disorder and complementary and nutritional therapies HERE Here is how we can stay in touch, I will always get back to you. Get my weekly Sacred Steps & Tips to turn autism around and take back your life HERE Barefoot Autism Warriors HERE Instagram HEREFacebook HERE

Gut, biotypes & nature. The missing link in all tests, protocols, and diets. This is why most of them do not give you results. All the practitioners who test, supplement and put you on diets will have clients who get worse or have no results at all. This includes all the current holistic autism practitioners.Protocols like SCD, Low Oxalate, Medical Medium, Feingold, Heavy Metal Detox, fish oil, methylated B, oxygen therapy, behavioral therapy and ALL interventions named after Doctors. If you have ever run gene, blood, saliva and urine tests and spent money on supplements without significant results, this podcast is for you. Links and ressources:Undermethylation and diets (excess greens = problem)Pyrrole disorder and autismCopper overload and anxiety /aggression/zinc depletionFish oil and pyrrole disorder (inflammation)Are we over-supplementing? Here is how we can stay in touch, I will always get back to you.Barefoot Autism Warriors HEREInstagram NINKA HEREFacebook Ninka HEREThe best way for us to keep in touch is joining my email list. I have exciting things to share for the coming months. Click HERE to join

Copper and Kryptopyrrole Details For Treatment Failure - 2From The CBJ Walsh Molecular Series: 2 of 4 A common problem in ADHD, behavior disorders, and hormonal depression is a genetic inability to control copper, zinc, manganese, and other trace metals in the body due to improper functioning of the https://en.wikipedia.org/wiki/Metallothionein#Metal_binding (metallothionine) protein. These patients are often deficient in trace metals, amino acids, and Vitamin B-6 and overloaded in others. They must avoid supplements and "enriched" foods containing copper..~ William WalshThis Copper & Kryptopyrrole Walsh Molecular Series RepublishedDr. Walsh Digs Deeper Dr. Bill Walsh describes in useful detail during this Episode from one of the three top downloads at CBJ [this is a republication [2] of the CBJ/034 download] that numbers now in the thousands. We think copper and kryptopyrrole imbalances bear repeating for all the new listeners not only because of their documented listening track record here but because they remain so overlooked and so frequently causal in treatment failure globally. In this Episode he clarifies how easy, cost-effective measurement and correction of unbalanced copper and kryptopyrrole levels caused by, for example, combat stress can significantly add to depression, even psychosis, and fans the flames of substance abuse. Just remember, psych meds don't touch these underlying measurable biomedical imbalances. Think: molecular physiology arrives at the street level. Yes, this data is available in the urban landscape of http://mapq.st/2s3Fjqb (Birdsnest, Virginia) on the Eastern Shore. PTSD, TBI, PMS, and estrogen dominance are all often associated with these biomedical findings – all of these can become amplified, measurable and correctable. Accurate measures must become a part of every future stress-recovery process. If you don't measure and treat it, it will not respond to psychiatric medications. Your Homework If You Haven't Preparedhttps://www.corebrainjournal.com/2016/06/025-william-walsh-methylation-insights/ (Methylation - CBJ/025 Published) - Start At This Link Copper & Kryptopyrrole -http://corebrainjournal.com/034 ( CBJ/034) Published First At This Link - No need to go back. http://corebrainjournal.com/034 (Schizophrenia & Bipolar - CBJ/042 Published) Coming Soon - CBJ: Walsh on Autism Copper [Cu] Overview: "Copper-overloaded depressives usually report that serotonin-enhancing antidepressants provide an improvement in moods, but they worsen anxiety. Benzodiazepines such as Klonopin and Xanax can be effective in reducing anxiety but are reported to have little effect on depression for this biotype. High-copper females are usually intolerant of birth control pills or hormone replacement therapy since these treatments increase copper levels in the blood. [96% of this biotype are women.]"[1] Consider chronic fatigue [CFS], terrible PMS with PMDD, and pervasive irritation with profound anxiety down to the marrow of your bones. https://www.corebrainjournal.com/wp-content/uploads/2016/07/copper-fatigue.jpg () Walsh Kryptopyrrole [Kp] Overview:"Pyrrole disorder typically involves high anxiety, poor behavioral control, a reading disorder, impaired immune function, and other troubling symptoms. We observe severe pyrrole levels in persons diagnosed with violent behaviors, depression, schizophrenia, and other serious mental disorders. A significant number of http://www.corepsych.com/2014/09/depression-walsh-biotypes-undermethylation/ (undermethylated depression) patients exhibit some degree of pyrrole disorder. Many persons with this combination of imbalances show high accomplishment throughout life, but report extreme internal anxiety and poor stress control along with depression. Since both undermethylation and pyrrole disorder present often with low serotonin activity, depression is usually more severe in these cases. Our database...

Today’s guest is Jules Galloway, who lives in Australia, while working as a passionate naturopath, speaker, podcaster, and recipe creator. Jules hosts a podcast, Shiny Healthy You, and loves surfing, hanging out with her husband and elderly rescued dogs, and walking the famous Byron Bay lighthouse track.  Jules recently returned from working as a volunteer at a refugee camp in Greece. She was drawn to this work and feels that her childfree entrepreneurial lifestyle allowed her the freedom to pursue that dream and fulfil that desire.  Jules knows all too well the toll that unhealthy living can take on mind and body. She went through a challenging childhood and youth, and then lived a party lifestyle for over a decade. She ditched the stressful city life for a fresh start and a peaceful setting in beautiful Byron Bay. After being diagnosed with Pyrrole disorder, adrenal fatigue, and a gene mutation, Jules learned the importance of nourishing herself with whole foods, supplements, happiness, gratitude, and a good sense of humour. With 10+ years of clinical experience as a naturopath, Jules has made it her mission to help women find their SHINE again through her work and her e-courses. Do you need help finding your SHINE? Join me to hear more from Jules! What you’ll hear in this episode: How both choice and circumstance have led to a childfree, 17-year marriage. Thoughts of having children were put on the back burner until she was about 30. Six months of trying for a pregnancy, and then a hiatus to buy a house. Busy with careers, and then a diagnosis of endometriosis. The pushy doctor who said, “Don’t wait until it's too late!” More health issues for Jules: adrenal fatigue, Pyrrole disorder, hormone issues, and a gene mutation problem. The move to Byron Bay, hoping for a quieter life and restored health Perfect house (for kids), perfect yard (for kids), perfect place (for kids)—but no kids! Weighing the pros and cons of what it would take to get pregnant. How friends influence the pressure you feel to have or not have kids. Dealing with family pressure, especially from a mother-in-law who desperately wants to be a grandmother. How to cope when those little moments of grief come?  Refocus on the joys and benefits of a child-free life: More time to focus on entrepreneurship. Freedom for surfing and other enjoyable activities. More time and attention to focus on husband, marriage and friendship. Never forgetting to be grateful for the freedom How Jules focuses her creative energy on a nurturing force in her business and with her clients. NOT having to decide who to focus energy on EVERY moment of EVERY day Being able to drop everything and go to a friend in need. The “Spare Auntie” who can help and support other mothers. Indirect pressure from friends. How Jules feels about parenthood in light of her personal childhood experiences. Respecting the different path and journey of every woman. Why fear of regret is NOT the best reason to decide to have a baby. Resources:  www.julesgalloway.com www.shinyhealthyyou.com   The Top Five Regrets of the Dying by Bronnie Ware I loved this conversation with Jules and I hope you do too! Please subscribe for more inspiring real-life stories from amazing women around the world. If you enjoyed this episode then I would be so grateful if you left a rating.  For more Unclassified Women, go to www.michellemariemcgrath.com      

Jules Galloway has no ordinary rags to riches story. There’s been times when she’s been homeless, has spent years working as an exotic dancer, ate a junk-food diet and had no real intentions of being a naturopath. These days Jules shares her wisdom with women who are finding it difficult to navigate through this fast-paced Listen In The post 100NO 186: From exotic dancer to naturopath. Jules Galloway on stress, pyrrole disorder & nutrition appeared first on The Wellness Couch.

Greg Newson is a qualified naturopath, herbalist, nutritionist, remedial massage therapist and has a clear passion for health and wellbeing. He treats people who are suffering from every day things like colds and flus right through to digestive issues, emotional and even life threatening conditions. His number one drive is to treat not just the symptoms of a disease but the underlying cause. This approach is unique to traditional practice found within medical centers and by GPs especially within Australia. Greg focuses on a particular disorder called pyrrole disorder, which is a biochemical imbalance that leaves the body unable to absorb key nutrients such as zinc at B6, which are vital for proper bodily function. Jo is particularly excited about this episode as she has recently been diagnosed with the disorder. Other than a seemingly endless list of alternative names for the disorder (kryptopyrole, mauve disorder and pyroluria to name a few) there is also a large array of symptoms and links to the disorder. Like many medical disorders, most people can have pyrrole and not even realise it. Greg discusses the reasons why you are likely to have the disorder and why the SAD diet (Standard American/Australian Diet) will see you devoid of key nutrients and what you can do to improve your diet and increase your intake of zinc and B6. Stress in particular devoids the body of B6 and can be a key factor to those suffering from pyrrole and we discuss ways to manage stress levels. Another important factor is maintaining a balance of good and bad bacteria in the gut and how the over presence of bad bacteria can be linked to pyrrole. We also get some tips on what lifestyle factors we can implement into our busy days to prevent the disorder from occurring in our lives and signs we can look for in children who might be suffering from the disorder. Links and Resources Websites: www.vitalityandwellness.com.au www.conqueringpyroluria.com Pyroluria free resources: www.conqueringpyroluria.com/free-resources

Naturopath Peter Mullen discusses pyrrole disorder.

Pyro-what? What is this pyroluria? The word pyroluria is a combination of pyrrole and urine. It refers to a molecule that shows up in the urine in most people. Pyrroles are molecules that are created from incomplete breakdown of red blood cells. Many kids with Reactive Attachment Disorder or RAD Disorder have pyroluria. Behavior problems can […] The post What you Need to Know about Pyrrole Disorder Symptoms-the Podcast appeared first on Gil Winkelman ND.

Welcome to another “Ask the Naturopath” show where I answer your burning health and wellness questions! This week we feature: Pyrrole disorder – I share my own experiences and give practical steps if you’ve been diagnosed with pyroluria. How to tackle adrenal fatigue, and the best herbs and supplements to look out for. And a Listen In The post SHY 8: Ask The Naturopath appeared first on The Wellness Couch.

Health and wellness consultant Phillip Rankin and Naturopath Peter Mullen talk about children's health and Pyrrole disorder.

Pyrrole-imidazole alkaloids represent a unique family of natural products which are exclusively found in marine sponges, mainly the Agelasidae, Axinellidae, and Halichondridae families. The pyrrole-imidazole alkaloids are fascinating due to thier biogenetic relationship leading to a large, strucurally diverse family based on a common key metabolite, oroidin. Some of the pyrrole-imidazole alkaloids have interesting biological activities, e. g., potent antitumor or antibacterial activities. One of these chellenging alkaloids is dibromophakellstatin which was first isolated from Phakellia mauritiana. In this work an efficient five step synthesis of dibromophakellstatin is described providing the natural product in an overall yield of 10%. Based on a broad investigation of the reactivity of dipyrrolopyrazinone-type enamides, a novel three component imidazolidinone anellation was exploited as the key step of the total synthesis. With this findings the overall yield of the synthesis could increased up to 18%. Based on these results it was possible to develope the first enantioselective total synthesis of (-)-dibromophakellstatin in a chiral pool approach (10 steps, 3.5% overall yield). In a collaboration effort the antitumor activity of dibromophakellstatin was confirmed. It was found that only the natural enantiomer shows biological activity by an unknown mechanism. Encouraged by the biological activity of (-)-dibromophakellstatin, different cyclopropane variations of the tetracyclic phakellin- and isophakellin scaffolds were obtained by reaction of dichlorocarbene with tri- and bicyclic precursors. Some of these compounds werde found to have interesting new anti proliferative activities.