PVRoundup Podcast

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Advances, headlines and buzz from the world of medicine in less than three minutes. Designed for clinicians with stories selected by the PeerDirect editorial board.

PeerDirect Publishing


    • May 28, 2025 LATEST EPISODE
    • weekdays NEW EPISODES
    • 8m AVG DURATION
    • 552 EPISODES


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    Latest episodes from PVRoundup Podcast

    Could a new rescue inhaler strategy reduce severe asthma attacks in mild cases?

    Play Episode Listen Later May 28, 2025 6:32


    This week's episode covers the effectiveness of a fixed-dose albuterol-budesonide combination for asthma, new findings on Nerodomelast for progressive pulmonary fibrosis, the FDA's endorsement of a new COVID-19 vaccine targeting the JN.1 lineage, and insights into extended-phase anticoagulation for pediatric venous thromboembolism.

    Could ending PEPFAR lead to 1 million new pediatric HIV cases by 2030?

    Play Episode Listen Later May 23, 2025 4:52


    A Lancet study warns of consequences for HIV prevention if PEPFAR loses funding, potentially millions of new pediatric HIV cases and increased AIDS-related deaths. Medicare Part D is highlighted, with research linking subsidy loss to higher mortality rates. A report from BMJ notes a 3.1% decline in U.S. drug overdose deaths, signaling a possible peak in the fentanyl crisis.

    Revisiting Anemia Response in Myelofibrosis: Revised International Working Group Criteria

    Play Episode Listen Later May 20, 2025 7:21


    Drs. Pemmaraju and Bose discuss the revised International Working Group criteria for anemia response in patients with myelofibrosis, outlining new definitions for transfusion status, gender-specific hemoglobin thresholds, and benchmarks for major and minor responses.

    Leukemic Transformation in Myelofibrosis: Risks, Realities, and Evolving Strategies

    Play Episode Listen Later May 19, 2025 7:34


    Drs. Bose and Pemmaraju discuss leukemic transformation in patients with myelofibrosis, reviewing its incidence, as well as risk factors, treatment, and prognosis.

    Understanding Secondary Myelofibrosis: Diagnosis, Treatment, and Prognosis

    Play Episode Listen Later May 16, 2025 6:08


    Drs. Bose and Pemmaraju review secondary myelofibrosis arising from polycythemia vera or essential thrombocythemia and how it differs from primary myelofibrosis that develops de novo.

    How much did maternal RSV vaccines and nirsevimab lower infant hospitalizations?

    Play Episode Listen Later May 14, 2025 4:47


    Maternal RSV vaccines and infant nirsevimab led to major drops in hospitalizations among infants ≤7 months, especially those ≤2 months old. The CDC's 2025 nPEP guidelines stress starting HIV prevention within 72 hours of exposure, with rapid testing and follow-up care. Treatment should begin without delay, and patients at ongoing risk should transition to PrEP. Surgical site infections after colorectal surgery have increased 21% since 2019, highlighting the need to strengthen infection control.

    Migraine Missteps: Common Diagnostic Pitfalls and How to Avoid Them

    Play Episode Listen Later May 9, 2025 13:19


    Drs. Starling and VanderPluym discuss common diagnostic pitfalls in migraine medicine and how the misinterpretation of symptoms can lead to unnecessary testing or incorrect treatments.

    Game Changer: Are CGRP Inhibitors the New First Line for Migraine Prevention?

    Play Episode Listen Later May 7, 2025 12:29


    Drs. VanderPluym and Starling review the updated position statement from the American Headache Society indicating that CGRP-targeting migraine therapies should be considered as a first-line option.

    Could a new HER2-targeted therapy change outcomes in previously treated NSCLC?

    Play Episode Listen Later May 6, 2025 5:11


    This episode features the Beamion LUNG-1 trial, where zongertinib showed a 71% response rate in previously treated HER2-mutant NSCLC patients. The EAGLE-1 trial found gepotidacin non-inferior to standard treatment for urogenital gonorrhoea, with a 92.6% success rate. The U.S. Department of Health and Human Services and NIH launched the Generation Gold Standard initiative, a universal vaccine platform targeting pandemic-prone viruses, with trials ongoing for H5N1 avian influenza and coronaviruses.

    Lifestyle and Cognitive Health: A discussion with Drs. Elizabeth Kensinger and Andrew Budson

    Play Episode Listen Later May 1, 2025 15:18


    Elizabeth Kensinger, PhD and Andrew Budson, MD explain how healthy lifestyle habits, memory offloading strategies, and turning facts into stories can support cognitive aging. They stress that enriching and novel activities are more effective for brain health than most apps. Dr. Budson supports the theory that beta amyloid defends against brain infections, linking it to viral triggers of Alzheimer's. He also highlights new drugs like lecanemab and donanemab that may slow early Alzheimer's progression and potentially prevent its onset.

    Could measles become endemic in the U.S. again within 25 years?

    Play Episode Listen Later Apr 30, 2025 5:02


    A JAMA model warns measles could become endemic in the U.S. within 21 years if MMR vaccination rates don't rise, with over 850,000 projected cases. A Phase 3 NEJM trial found brensocatib reduced exacerbations in non-CF bronchiectasis. An EPIC study correlated higher breast cancer risk to higher education levels, beyond lifestyle and reproductive factors.

    What does Mexico's first fatal H5N1 avian flu case tell us about current risks to humans?

    Play Episode Listen Later Apr 22, 2025 5:05


    Mexico's first fatal H5N1 case involved a healthy child and highlights localized risk despite low global concern. Long-term antidepressant use was linked to higher sudden cardiac death risk, especially in younger adults. A U.S. study found 25% of adults with very high LDL cholesterol lacked statin treatment. These stories reveal persistent gaps in infection control, cardiac monitoring, and preventive care.

    Could genetic testing improve prostate cancer screening beyond PSA?

    Play Episode Listen Later Apr 15, 2025 5:43


    A polygenic risk score significantly improved prostate cancer detection beyond PSA testing, identifying more treatable and aggressive cancers in high-risk men. New WHO guidelines aim to reduce global meningitis deaths by standardizing early diagnosis, treatment, and care across settings. GLP-1 receptor agonists and SGLT2 inhibitors were linked to reduced Alzheimer's risk, with GLP-1s showing the most consistent neuroprotective effects in recent studies. Lastly, breast cancer mortality was 47% higher among Black women living in disadvantaged neighborhoods, underscoring the impact of social determinants on survival.

    Mary Beth Cicero on Reimagining the IUD: A Painless Future for Contraception

    Play Episode Listen Later Apr 10, 2025 19:05


    Mary Beth Cicero, co-founder of Three Daughters, shares how her passion for women's health led to the development of a new frameless, self-assembling magnetic IUD designed to significantly reduce the pain of insertion and retrieval. The device, inspired by embryo transfer techniques and using copper as its active ingredient, aims to improve comfort, eliminate strings, and offer a more body-conforming contraceptive option—especially for younger women deterred by current IUDs. As the product moves through clinical trials, the team is focused on both efficacy and ease of use, with hopes to expand into treating other uterine conditions in the future.

    Could a shingles vaccine delay dementia more effectively than current medications?

    Play Episode Listen Later Apr 8, 2025 4:50


    A large study in Wales found that older adults who received the shingles vaccine had a 20% lower risk of developing dementia over seven years, with the strongest effect seen in women. U.S. measles cases have surged past 500, driven largely by outbreaks in West Texas and linked to international travel, underscoring critical gaps in vaccination coverage. Meanwhile, new research shows that even the wealthiest Americans have shorter life expectancies than their European peers, pointing to systemic health disadvantages in the U.S.

    HER2+ Lung Cancer Treatment: Past, Present, and Future

    Play Episode Listen Later Apr 2, 2025 10:05


    Drs. Yu and Sabari trace the evolution of HER2-mutant lung cancer treatment from chemotherapy to targeted therapies, highlighting key advancements, challenges, and patient responses. They also explore emerging treatment strategies, resistance mechanisms, and the future of personalized therapy based on biomarkers and co-mutations.

    Can statins reduce liver cancer risk in patients with chronic liver disease?

    Play Episode Listen Later Apr 1, 2025 4:53


    A study published in JAMA Internal Medicine found that statin use in patients with chronic liver disease was associated with a lower risk of liver cancer and hepatic decompensation, suggesting potential protective effects beyond lipid management. Surveys by the Annenberg Public Policy Center revealed widespread misinformation about the risks of consuming raw milk, highlighting the need for public education on the importance of pasteurization. New research links red meat allergy (alpha-gal syndrome) to bites from deer ticks and western black-legged ticks, expanding the geographic risk area and emphasizing the need for clinicians to consider this diagnosis in patients with unexplained allergic symptoms following tick bites.

    HER2 Alterations in Lung Cancer

    Play Episode Listen Later Mar 31, 2025 8:52


    Drs. Sabari and Yu discuss the molecular landscape of HER2-mutant lung cancer, including its genomic characteristics, common co-mutations, and differences between HER2 mutations and HER2 amplification. This discussion also explores the prevalence and clinical patterns of HER2 mutations, their oncogenic mechanisms, their impact on tumor behavior and metastases, and potential environmental or genetic contributors to their development.

    HER2 Biomarker Testing in Lung Cancer

    Play Episode Listen Later Mar 28, 2025 9:40


    Helena Yu, MD and Joshua Sabari, MD explore the importance of testing for HER2 alterations in lung cancer; how HER2 positivity influences clinical decision-making; and the key methods used for detection, including immunohistochemistry, fluorescence in situ hybridization, and next-generation sequencing. It also addresses challenges in standardizing HER2 testing, disparities in access to biomarker testing, and the evolving role of liquid biopsy compared to traditional tissue biopsy.

    Migraine: Updates from the 2024 European Headache Congress

    Play Episode Listen Later Mar 27, 2025 16:44


    Carrie Dougherty, MD, FAHS and Jessica Ailani, MD review migraine abstracts from the 2024 European Headache Congress.

    Could a new combination improve first-line therapy for myelofibrosis?

    Play Episode Listen Later Mar 26, 2025 4:57


    A phase 3 study showed that combining pelabresib with ruxolitinib significantly improved spleen volume reduction and symptom relief in myelofibrosis patients compared to ruxolitinib alone, offering a promising new treatment option. Long-term use of gantenerumab may delay Alzheimer's dementia onset in individuals with inherited Alzheimer's, supporting the amyloid hypothesis and paving the way for future prevention strategies. Phase 3 trials demonstrated that povorcitinib, an oral JAK1 inhibitor, significantly improved clinical outcomes in adults with moderate to severe hidradenitis suppurativa, potentially offering a new treatment option. Research linked red meat allergy to bites from additional tick species, expanding the geographic risk area and highlighting the need for clinicians to consider this diagnosis in patients with unexplained allergic symptoms following tick bites.

    Migraine Debates: Initial Preventive Therapy and Status Migraine

    Play Episode Listen Later Mar 25, 2025 14:03


    Jessica Ailani, MD and Carrie Dougherty, MD, FAHS debate initial preventive treatment for migraine and the in-clinic management of status migraine.

    Pharmacological Management of Postpartum Depression: Pros and Cons

    Play Episode Listen Later Mar 24, 2025 14:49


    Drs. Lebin and Nagle-Yang discuss the pharmacological management of PPD, with a focus on the risks and benefits of selective serotonin reuptake inhibitors (SSRIs) and zuranolone.

    Barriers to Care Engagement for Postpartum Depression

    Play Episode Listen Later Mar 21, 2025 12:34


    Drs. Nagle-Yang and Lebin discuss the barriers to care engagement for patients with PPD, including such factors as stigma, fear of judgement, and access to treatment.

    Suicide Risk in Postpartum Depression: Screening and Management

    Play Episode Listen Later Mar 20, 2025 15:44


    Sarah Nagle-Yang, MD and Lindsay Lebin, MD review the screening, impact, and management of suicide risk in patients with PPD, highlighting effective prevention strategies.

    Could GLP-1 receptor agonists reduce the risk of blood cancers in type 2 diabetes patients?

    Play Episode Listen Later Mar 18, 2025 4:54


    A study suggests GLP-1 receptor agonists may reduce hematologic cancer risk in type 2 diabetes patients by 54% compared to insulin. Two individuals have achieved functional HIV cures through stem cell transplants, offering insights into cure strategies. Additionally, women with dense breasts face double the risk of breast cancer and reduced mammogram accuracy, supporting FDA regulations for breast density notifications and additional screening methods.

    Can AI reduce false positives and biopsies in breast ultrasound exams?

    Play Episode Listen Later Mar 11, 2025 4:56


    An AI system trained on breast ultrasound studies showed promise in reducing false positives and biopsies by over 37% and 28%, respectively, while maintaining sensitivity, potentially aiding clinical decision-making. Second, nirsevimab demonstrated effectiveness in preventing RSV infections and hospitalizations among infants, with protection waning over time but remaining significant. Lastly, breast and colon cancer screening rates in the U.S. have surpassed pre-pandemic levels, but cervical cancer screening rates remain concerningly low, highlighting disparities in access to preventive care.

    Osteoporosis: Common Questions and Clinical Conundrums

    Play Episode Listen Later Mar 10, 2025 13:00


    Drs. McClung and Singer delve into common questions and clinical conundrums encountered in managing osteoporosis and fractures, including calcium use and dental procedures, in patients with osteoporosis.

    Operationalization of a Bisphosphonate “Drug Holiday”

    Play Episode Listen Later Mar 7, 2025 13:12


    Drs. Singer and McClung discuss the operationalization of a bisphosphonate “drug holiday” in people treated with this class of osteoporosis medication. They address questions regarding patient selection criteria, duration of the holiday, and strategies for determining when and with what medication treatment should be resumed.

    Preservation of Perimenopausal Bone Health

    Play Episode Listen Later Mar 5, 2025 9:56


    Andrea J. Singer, MD, FACP, CCD and Michael R. McClung, MD review the preservation of bone health in perimenopausal women, with a particular focus on the role of hormone therapy and how the interplay of hormonal, lifestyle, and genetic factors is key to developing effective prevention and treatment strategies.

    What are the details around the first measles death in the US in 10 years?

    Play Episode Listen Later Mar 4, 2025 6:26


    A Texas child's measles-related death, the first in the U.S. since 2015, highlights rising cases amid declining vaccination rates. AstraZeneca's Serena 6 trial found camizestrant, delayed disease progression in HR-positive HER2-negative breast cancer. A BMJ study found no link between GLP-1 receptor agonists and increased suicidality in diabetes patients. The CDC reports an 80% decline in high-risk cervical precancers, confirming HPV vaccination success.

    Dr. Andrew Budson on consciousness and the role they play on memory

    Play Episode Listen Later Mar 3, 2025 29:26


    Dr. Andrew Budson discusses the relationship between consciousness and memory, proposing that consciousness evolved as part of the memory system. He explains how unconscious processes drive much of our decision-making, with consciousness acting as a memory-based guide to influence behavior. He highlights the role of attention in memory retention and how false memories, particularly in Alzheimer's patients, arise due to the brain's reconstructive nature. Dr. Budson also explores the implications of this understanding for treating PTSD, addiction, and cognitive disorders.

    How severe is this flu season compared to recent years?

    Play Episode Listen Later Feb 27, 2025 6:54


    This podcast reports a severe flu season, with hospitalizations exceeding previous years and rising pediatric flu deaths. A Texas measles outbreak, mainly in unvaccinated children, has reached nearly 60 cases, with more in New Mexico, highlighting vaccine decline risks. Research finds moderate to vigorous leisure activity lowers type 2 diabetes risk, while strenuous work activity does not. A UCLA study questions Paxlovid's effectiveness in preventing COVID-19 hospitalizations in vaccinated older adults, raising cost-effectiveness concerns.

    Navigating HER2+ Early Breast Cancer: When to Use Neoadjuvant Therapies, Addressing Residual Disease, and Potential Treatment Toxicities

    Play Episode Listen Later Feb 21, 2025 8:45


    Drs. Traina and Isaacs share how they determine which patients are appropriate for neoadjuvant therapies and how to address residual disease, as well as potential treatment toxicities.

    Navigating HER2+ Early Breast Cancer: Diagnosis, Treatment Planning, and De-Escalation

    Play Episode Listen Later Feb 21, 2025 7:56


    Drs. Tiffany A. Traina and Claudine Isaacs discuss how they approach HER2+ early breast cancer treatment planning and which patients can take advantage of de-escalation.

    Why are measles outbreaks surging in Texas and New Mexico?

    Play Episode Listen Later Feb 20, 2025 4:53


    Measles cases are rising in Texas and New Mexico, with most infections occurring in unvaccinated individuals and public health officials warning of further spread. A new study in JAMA Psychiatry found that semaglutide significantly reduces alcohol craving and heavy drinking, suggesting a potential new treatment for alcohol use disorder. Research confirms that self-sampling for HPV is as effective as speculum-based exams, improving accessibility for women with disabilities and underserved populations. With the FDA's recent approval, self-collection could revolutionize cervical cancer screening in the U.S.

    Specialist Spotlight: Parental favoritism and its impact on family dynamics and mental health

    Play Episode Listen Later Feb 18, 2025 21:45


    Professor Alexander Jensen discusses parental favoritism and its impact on family dynamics, highlighting that both mothers and fathers tend to favor daughters, potentially due to social and evolutionary factors. The study suggests that children who receive less favorable treatment may experience negative mental health and behavioral outcomes, including increased risk-taking and lower self-esteem. The discussion also touches on how favoritism can persist into adulthood, influencing sibling relationships, caregiving responsibilities, and even long-term physical health.

    Specialist Spotlight: Marlie Tondac investigating learning and attention in young children.

    Play Episode Listen Later Feb 13, 2025 15:40


    This podcast features Marlee Tunduk, the lead author of a study on learning and attention in young children finding that children aged 7 to 9 learn differently from adults; they absorb information more generally from their environment, regardless of specific tasks or goals. This "sponge-like" learning suggests that children benefit from immersive and engaging environments rather than structured, task-focused learning. The findings highlight the importance of understanding and accommodating children's natural attentional systems in educational and parenting contexts. The discussion also touches on the potential implications for teaching methods and future research directions, emphasizing the need to explore how these learning differences manifest in various settings.

    Can a urine test reduce unnecessary prostate biopsies?

    Play Episode Listen Later Feb 11, 2025 4:56


    Can a urine test reduce unnecessary prostate biopsies?

    Could immunotherapy redefine treatment for Estrogen Receptor positive/HER2 negative breast cancer?

    Play Episode Listen Later Feb 4, 2025 4:33


    A new phase 3 trial demonstrated that adding nivolumab to adjuvant chemotherapy significantly improves outcomes for patients with ER-positive HER2-negative breast cancers. Heavy lifetime cannabis use was associated with reduced brain activity in areas responsible for working memory, suggesting potential long-term cognitive impacts. A study found that EMS clinicians wearing ballistic vests experienced higher rates of workplace violence and increased patient refusal of treatment, particularly among racial and ethnic minority patients.

    Approaching Tough Discussions in ILDs: Lung Transplantation and End-of-Life Issues

    Play Episode Listen Later Jan 30, 2025 13:47


    Drs. Solomon and Swigris review how they discuss lung transplantation with patients with ILDs, as well their philosophies of addressing end-of-life issues and the use of opioids in managing symptoms in these patients.

    Insights Into Managing Comorbidities, Discussing Quality of Life, and Benefits of Pulmonary Rehab in Patients With ILDs

    Play Episode Listen Later Jan 29, 2025 12:02


    Drs. Solomon and Swigris focus on the importance of managing comorbidities and addressing treatment-related adverse events, such as GERD and mood disorders, in patients with ILDs to improve quality of life. Pulmonary rehabilitation is also emphasized as a vital component of care for these patients.

    Could a fully human monoclonal antibody reduce bleeding risk in atrial fibrillation patients?

    Play Episode Listen Later Jan 29, 2025 6:10


    A study in NEJM shows that abelacimab, a fully human monoclonal antibody targeting factor XI, significantly reduces bleeding risk compared to rivaroxaban in atrial fibrillation patients, suggesting a safer alternative for stroke prevention. Data from JAMA Health Forum reveals growing consolidation of primary care practices by hospitals and private equity firms, driving up healthcare costs without clear quality improvements. The largest U.S. tuberculosis outbreak in Kansas underscores the importance of vigilance and rapid response by healthcare providers, while a study in JAMA Network Open finds women, particularly nonmenopausal females aged 40–54, at higher risk for long COVID, emphasizing the need for tailored prevention and treatment strategies.

    Principles of Selecting Pharmacotherapy for ILDs

    Play Episode Listen Later Jan 28, 2025 11:21


    Drs. Solomon and Swigris discuss how the treatment of ILDs demands a personalized approach based on the underlying cause and progression of the condition. They explore therapeutic options, including antifibrotic agents and immunosuppressive therapies.

    Diagnosing and Classifying ILDs

    Play Episode Listen Later Jan 27, 2025 8:45


    Joshua Solomon, MD and Jeff Swigris, DO discuss ILDs, a group of conditions marked by lung inflammation and fibrosis. They explore classifications, common causes, and advancements in understanding of these disorders to support effective diagnosis and management.

    What is the impact of red meat intake and the risk of dementia and cognitive decline?

    Play Episode Listen Later Jan 21, 2025 4:59


    A study in Neurology links high intake of processed red meat to an increased risk of dementia and cognitive decline, with dietary changes showing protective effects. Research in the Journal of Arthroplasty highlights that COVID-19 infection within six weeks before knee surgery significantly raises the risk of venous thromboembolism. Wearable devices, such as Apple Watch and Fitbit, can predict inflammatory bowel disease (IBD) flares up to seven weeks in advance by monitoring physiological metrics, offering a valuable tool for early intervention.

    The Process of Preparing Patients for Food Oral Immunotherapy – International Consensus for Procedural Preparation and Consent: Part 3

    Play Episode Listen Later Jan 21, 2025 15:08


    This discussion emphasizes the importance of risk mitigation strategies and practical tips for implementing oral immunotherapy (OIT) in clinical practice. Key points include ensuring adult supervision during dosing, adhering to safe dosing rules to minimize allergic reactions, and maintaining close communication with healthcare providers for adjustments or emergencies. The conversation highlights the challenges of adherence, the need for proper patient and caregiver training, and the critical role of informed consent in supporting successful and safe long-term OIT management.

    The Process of Preparing Patients for Food Oral Immunotherapy – International Consensus for Procedural Preparation and Consent: Part 2

    Play Episode Listen Later Jan 20, 2025 10:32


    In this discussion, Dr. Anagnostou and Dr. Greenhot review key elements for informed consent in oral immunotherapy (OIT), emphasizing the benefits, risks, and outcomes of the treatment. They highlight OIT's ability to increase allergen tolerance thresholds, while acknowledging potential risks like dose-related reactions and rare conditions such as eosinophilic gastrointestinal disorders. Alternatives to OIT, including food avoidance, emerging biologics, and clinical trial participation, are also discussed, with a focus on empowering clinicians to guide families in making informed decisions.

    The Process of Preparing Patients for Food Oral Immunotherapy – International Consensus for Procedural Preparation and Consent: Part 1

    Play Episode Listen Later Jan 17, 2025 18:30


    Aikaterini Anagnostou, MD (Hons), MSc, PhD and Matthew Greenhawt, MD, MBA, MSc discuss the process of preparing patients for oral immunotherapy (OIT). This first part of a 3-part video highlights the development and findings of the first International Delphi Consensus Panel on preparing patients for oral immunotherapy (OIT). Experts created a standardized checklist and consent framework to guide clinicians in counseling families about OIT, emphasizing its long-term, stepwise desensitization process and associated risks. Key considerations include controlling patient comorbidities like asthma, ensuring family commitment and agreement, and tailoring counseling to logistical and cultural factors to optimize adherence and success.

    The Basics of HER2+ in Lung Cancers

    Play Episode Listen Later Jan 16, 2025 12:25


    Tejas Patil, MD and Sami Diab, MD discuss the pivotal role HER2 positivity plays in lung cancer including the challenges faced by clinicians in testing for HER2. They discuss topics in sequencing, next generation testing, and liquid biopsies as well as challenges of testing in tissue-efficient manner.

    2024 San Antonio Breast Cancer Symposium Insights on HER2+ Early Breast Cancer: MARGOT Trial, Risk-Reducing Surgeries/Survival, and More

    Play Episode Listen Later Jan 15, 2025 15:26


    Drs. Isaacs and Traina share insights from the 2024 San Antonio Breast Symposium, covering the MARGOT trial, survival impacts of risk-reducing surgeries in young BRCA carriers, and outcomes of delaying surgery in operable breast cancer.

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