Podcasts about surgical sciences

In a conversation with CancerNetwork®, Viviana Cortiana, MS4, and Yan Leyfman, MD, spoke about their manuscript titled “Artificial Intelligence in Cancer Care: Addressing Challenges and Health Equity,” which they published in the April 2025 issue of ONCOLOGY®. Cortiana is a medical student in the Department of Medical and Surgical Sciences at the University of Bologna. Leyfman is a resident physician from the Icahn School of Medicine of the Mount Sinai Health System. Cortiana highlighted how artificial intelligence (AI)–based tools may mitigate the overdiagnosis of cancers, although she noted a need to validate these devices with diverse and high-quality datasets to avoid the risk of biased models. Additionally, she described how developing population-specific AI models may improve predictive accuracy in diagnosis as well as treatment planning, which can especially benefit patients in low- and middle-income countries. As part of ethically applying the use of AI to oncology and delivering equitable cancer care, Leyfman emphasized core pillars such as data security, transparency, clinical validation, and combatting algorithmic bias. Furthermore, he stated that potential applications of these tools include mobile diagnostics, cloud-based platforms, and remote consultation, which can help increase access to care. Regarding the potential next steps in the field, he highlighted that global partnerships with parties such as tech companies, governments, and non-governmental organizations may assist with the funding and deployment of AI tools, especially for underserved regions. “The future of AI in oncology is increasingly promising, not just in pushing the boundaries of what's possible in cancer care but also making sure that more precise and more accessible worldwide therapies are available,” Leyfman stated. “AI has the potential to fundamentally change how we detect, treat, and monitor [cancer], but realizing that promise, especially in a way that's equitable, will require collaboration, validation, thoughtful implementation, and a commitment to leaving no patient behind.”

In a conversation with CancerNetwork®, Viviana Cortiana, MS4, medical student in the Department of Medical and Surgical Sciences at the University of Bologna, and Yan Leyfman, MD, a resident physician from the Icahn School of Medicine of the Mount Sinai Health System, discussed their publication in the March 2025 issue of ONCOLOGY titled “Expanding horizons in T-cell lymphoma therapy: a focus on personalized treatment strategies.” Throughout the discussion, the authors spoke about the current lymphoma landscape, CAR T-cell therapy, and the evolving understanding of the tumor microenvironment. Specifically, Cortiana covered a shift from histology-based classification to molecular tumor type classification using next-generation sequencing, as well as a growing interest in biomarker-driven therapies. Regarding the limited efficacy of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) in T-cell lymphoma, she listed potential advances in combination therapies for angioimmunoblastic T-cell lymphoma (AITL), which include combining P13K and HDAC inhibition as well as CD30- and TRBC1-targeting CAR T-cell therapies. Furthermore, Leyfman discussed strategies that “reprogram” the microenvironment to address malignant T cells, particularly through epigenetic and adoptive cell therapies. Leyfman concluded by discussing future implications for T-cell lymphoma treatment, emphasizing an emergence of precision medicines and armored CAR engineering strategies. Authors of the manuscript published in ONCOLOGY outlined the available treatment options for peripheral T-cell lymphoma (PTCL), which include targeted therapies through EZH2 inhibition, chemotherapy with CHOP, CAR T-cell therapies, and allogenic stem cell transplantation. Additionally, they highlighted encouraging results from clinical trials evaluating epigenetic-targeted therapies through the identification of molecular aberrations, which can help tailor treatments to individual patients.  Furthermore, the article explored limitations of chemotherapy as well as autologous stem cell transplantation (ASCT), which may not be feasible for older patients or those with comorbidities. Authors suggested that targeted therapies may enhance tumor specificity while reducing systemic toxicity. Given the risks associated with ASCT, they emphaisized a focus on the incorporation of optimized treatment strategies, such as novel pharmaceuticals and combination therapies, into clinical practice for patients with PTCL.

John Maytham and Professor Derrick Smit, Associate Professor in the Division of Ophthalmology at the Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, discuss the ground-breaking artificial cornea procedures performed at Tygerberg Hospital. They highlight the life-changing impact on two patients who regained sight after years of blindness.See omnystudio.com/listener for privacy information.

Michela Starace, Department of Medical and Surgical Sciences, University of Bologna, Italy, joins Jonathan to discuss hair loss and its impact on the lives of patients. They also explore how symptoms of conditions can present in nails, and how to treat benign nail tumours. Use the following timestamps to navigate the topics discussed in this episode: (00:00)-Introduction (01:53)-What led Starace into medicine, and the field of dermatology (03:20)-Alopecia areata, the role of JAK inhibitors, and adverse treatment events (06:40)-Commonality of alopecia areata, and its recent reclassification as an autoimmune disease (07:35)-Health-related quality of life and psychosocial anxiety in patients with hair loss (10:03)-Recommendations for the treatment of female androgenetic alopecia (12:03)-The role of trichoscopy in diagnostics (14:36)-Onychoscopy in the diagnosis of nail disorders (17:58)-The International Nail Society's hopes for the future (19:00)-Atopic dermatitis in adolescents (20:08)-Presentation and treatment of benign nail unit tumours (23:32)-Doctor-patient relationship in dermatology (25:23)-Innovations in the field (26:57)-Three wishes for the future of healthcare

Coinciding with the launch of a new global campaign by ReSurge International to promote greater awareness & funding for local surgical teams to provide life-changing reconstructive care, we meet Jim Chang and Natalie Meyers of ReSurge, along with ground-breaking Zimbabwean surgeon, Godfrey Muguti, to ask why 18 million die every year from surgically preventable diseases - and what can be done about it.  Guests: Professor Jim Chang, Chief of Plastic Surgery, Stanford University & Consulting Medical Officer, ReSurge International Professor Godfrey Muguti, Chair Department of Surgical Sciences, University of Zimbabwe Natalie Meyers, Chief Program Officer, ReSurge International Links: https://resurge.org https://www.uz.ac.zw/index.php/chs-departments/355-dept-of-surgery https://www.globalsurgeryfoundation.org https://plasticsurgery.stanford.edu/Team.html https://www.ashotinthearmpodcast.com Watch the ReSurge Gala: https://www.youtube.com/@resurgeinternational Donate to ReSurge https://resurge.org/donate ReSurge on Social: Twitter: @ReSurge Instagram: https://www.instagram.com/resurgeinternational #cleftpalate #burns #travelaccidents #reconstructivesurgery #trauma #congenitalconditions #cancer #genderequity #globalsolidarity ---- YouTube Link https://youtu.be/OY9RverDeug -| The Health Equity Podcast Channel is made possible with support from Bayer G4A. Learn more about how Bayer G4A is advancing equity, access and sustainability at G4a.health -| This episode originally aired on March 29, 2023 on A Shot in the Arm Podcast with Ben Plumley. Listen, follow and subscribe here.

The CE experience for this Podcast is powered by CMEfy - click here to reflect and earn credits: https://earnc.me/GOK3uN   Dr Addison May is Chief of Acute Care Surgery for the Atrium Health system and Carolinas Medical Center in Charlotte, North Carolina. Prior to assuming this role in 2018, he held the Ingram Chair in Surgical Sciences and was Professor of Surgery and Anaesthesiology at Vanderbilt University Medical Center where he served as the Director of Surgical Critical Care and the Program Director of Vanderbilt's Surgical Critical Care and Acute Care Surgery Fellowship for 17 years. Dr May is a past President of the Surgical Infection Society, past Chair of the Surgical Section of the Society of Critical Care Medicine, a fellow of the American College of Critical Care Medicine and the American College of Surgery, and a recipient of the Barry A. Shapiro Memorial Award for Excellence in Critical Care awarded by the American College of Critical Care Medicine. He has published greater than 230 peer reviewed manuscripts, book chapters, and editorials predominately in the areas of surgical infections, critical illness, and trauma.   Today's Episode is brought to you by Doc2Doc Lending. Doc2Doc provides Match Day loans of up to $25,000 to fourth-year medical students and current residents. These loans are designed to help students cover personal expenses, such as moving costs, housing down payments, and living expenses before and during residency. With fixed interest rates, flexible repayment terms, and no prepayment penalties, Doc2Doc Match Day loans provide financial flexibility and allow students to focus on their exciting journey towards becoming a physician. Doc2Doc was founded for doctors, by doctors. They understand the challenges and hard work involved in becoming a doctor, and they support doctors throughout their careers. Using their in-house lending platform, Doc2Doc considers the unique financial considerations of doctors that are not typically considered by traditional financial institutions. So, Don't let financial stress hold you back from achieving your goals - Doc2Doc lending has you covered. Visit www.doc2doclending.com/mdcoaches to Learn more.       Join the Conversation! We want to hear from you! Do you have additional thoughts about today's topic? Do you have your own Prescription for Success? Record a message on Speakpipe   Unlock Bonus content and get the shows early on our Patreon Follow us or Subscribe: Apple Podcasts | Google Podcasts | Stitcher | Amazon  | Spotify --- Show notes at https://rxforsuccesspodcast.com/148 Report-out with comments or feedback at https://rxforsuccesspodcast.com/report Music by Ryan Jones. Find Ryan on Instagram at _ryjones_, Contact Ryan at ryjonesofficial@gmail.com Production assistance by Clawson Solutions Group, find them on the web at csolgroup.com    

Coinciding with the launch of a new global campaign by ReSurge International to promote greater awareness & funding for local surgical teams to provide life-changing reconstructive care, we meet Jim Chang and Natalie Meyers of ReSurge, along with ground-breaking Zimbabwean surgeon, Godfrey Muguti, to ask why 18 million die every year from surgically preventable diseases - and what can be done about it.  Guests: Professor Jim Chang, Chief of Plastic Surgery, Stanford University & Consulting Medical Officer, ReSurge International Professor Godfrey Muguti, Chair Department of Surgical Sciences, University of Zimbabwe Natalie Meyers, Chief Program Officer, ReSurge International Links: https://resurge.org https://www.uz.ac.zw/index.php/chs-departments/355-dept-of-surgery https://www.globalsurgeryfoundation.org https://plasticsurgery.stanford.edu/Team.html https://www.ashotinthearmpodcast.com Watch the ReSurge Gala: https://www.youtube.com/@resurgeinternational Donate to ReSurge https://resurge.org/donate ReSurge on Social: Twitter: @ReSurge Instagram: https://www.instagram.com/resurgeinternational #cleftpalate #burns #travelaccidents #reconstructivesurgery #trauma #congenitalconditions #cancer #genderequity #globalsolidarity ---- YouTube Link https://youtu.be/OY9RverDeug

Bronchiolitis is a common lung infection in young children and infants. Approximately one-tenth of the affected children are admitted, and between 2 and 6% of them present a severe form and are referred to paediatric intensive care units. Nevertheless, the definition of severe acute bronchiolitis is mainly clinical and based on low levels of evidence.In this podcast, Dr Milési presents guidelines for managing infants under 12 months of age with severe bronchiolitis to create a series of pragmatic recommendations for a patient subgroup poorly individualised in national and international guidelines. Original paper: Clinical practice guidelines: management of severe bronchiolitis in infants under 12 months old admitted to a paediatric critical care unitSpeakersChristophe MILÉSI. Pediatric Intensive Care Unit, Montpellier University Hospital (FR).Mariangela PELLEGRINI. Dept. of Surgical Sciences, Uppsala University (SE).

Videos: Ontario College of Physicians and Surgeons state unvaccinated are meantally ill (0:48) Pandemic Amnesty': Do you Forgive and Forget? (8:19) Experts try to calm the angry AI, w Elon Musk Part 2 –  (8:00) MEP Clare Daly – Speech from Nov 23 (1:12) How Long Would Society Last During a Total Grid Collapse? (14:56)   The ultimate stress buster: L-theanine Columbia University Medical Center,  November 16, 2022 Honestly, who would have thought that stress can cause heart damage equivalent to smoking five cigarettes? This is according to a study conducted by Columbia University Medical Center and published in the American Journal of Cardiology.  The study reveals how an amino acid known as L-theanine reduces both stress levels and heart rate.  As a way to increase stress levels, scientists asked 12 participants to solve a mentally stressful task in four double blind trials. L-theanine was given to participants in one of the four trials before dealing with the stressful task.  In the second group, study subjects took L-theanine midway through the work.  In the third and fourth variations, subjects were respectively given a placebo and nothing at all before attempting the task. In comparison to the placebo group, there was a reduced amount of immunoglobulin (a stress marker in saliva released by the immune system after exposure to viruses, bacteria, and other foreign entities) and a lower heart rate in participants who took L-theanine. The researchers explained that L-theanine works by suppressing the sympathetic nervous system responsible for the ‘fight or flight' response during emergency situations. This is achieved by blocking a chemical known as glutamate (L-glutamic acid) that carries electric signals transmitted from nerve cells to the rest of the body cells. The conclusion was that L-theanine plays a major role in terms of influencing psychology (mind) and physiology (body) function during stressful situation. Greater flavonoid intake associated with less arterial calcification Edith Cowen University (Australia), November 23 2022.  The December 2022 issue of Arteriosclerosis, Thrombosis, and Vascular Biology reported a study that uncovered a relationship between greater consumption of plant compounds known as flavonoids and decreased calcification in the abdominal aorta, which supplies blood to the abdominal organs and lower limbs.  Greater abdominal aortic calcification has been associated with an increased risk of stroke, heart attack and dementia.  The study included 881 participants in the Perth Longitudinal Study of Ageing Women. Dietary questionnaire responses were analyzed to determine total and individual flavonoid intake.  Women whose total flavonoid intake was among the top 25% of participants had a 36% lower risk of extensive abdominal aortic calcification than women whose intake was among the lowest 25%. Among women whose intake of individual flavonoids known as flavan-3-ols and flavonols was among the top 25%, respective risks were 39% and 38% lower.  Those who consumed 2–6 cups per day of black tea (the main source of total flavonoid intake in this study), had a 16%–42% lower risk of extensive abdominal aortic calcification than women who were not tea drinkers.  “In most populations, a small group of foods and beverages—uniquely high in flavonoids—contribute the bulk of total dietary flavonoid intake,” first author Ben Parmenter noted. “The main contributors are usually black or green tea, blueberries, strawberries, oranges, red wine, apples, raisins/grapes and dark chocolate.”  “Out of the women who don't drink black tea, higher total non-tea flavonoid intake also appears to protect against extensive calcification of the arteries,” he continued. “This implies flavonoids from sources other than black tea may be protective against abdominal aortic calcification when tea is not consumed.” “Abdominal aortic calcification is a major predictor of vascular disease events, and this study shows intake of flavonoids, that could protect against abdominal aortic calcification, are easily achievable in most people's diets,” he concluded. Researchers discover that vitamin C improves health for children of pregnant smokers Oregon Health & Science University, November 22, 2022 Researchers at Oregon Health & Science University have found that vitamin C supplementation to pregnant women unable to quit smoking significantly improves airway function and respiratory health in their offspring at 5 years of age. While previous studies have shown that vitamin C improves airway function in infants, this is the first study to demonstrate that the improvement in airway function can be maintained through preschool age. The study published this week in JAMA Pediatrics. Despite anti-smoking efforts and a steady decrease of smoking among the adult population over the past decade, the addictive properties of tobacco products can make quitting smoking incredibly challenging for many individuals. Roughly 10% of American women continue to smoke in pregnancy, each year resulting in about 400,000 infants being exposed to smoke in-utero, or in the uterus. In-utero smoke exposure from maternal smoking during pregnancy can be dangerous for a developing baby and is linked to poor health outcomes, including impaired fetal lung development, decreased airway function and an increased risk for wheezing and asthma. Additionally, decreased airway growth early in life causes increased risk for serious lifelong conditions, such as chronic obstructive pulmonary disease, which is now the third leading cause of death worldwide. For this study, participating women were enrolled in a double-blind, randomized controlled trial to receive either vitamin C (500 mg/day) or a placebo. Statistical analyses showed that the effect of vitamin C supplementation to pregnant smokers prior to 23 weeks of gestation consistently resulted in significantly better airway function in their offspring at 5 years old. While the findings may improve the health of the many children who face in-utero smoke exposure, these findings may have even broader implications: The results may potentially lead to better understanding of—and treatments for—the health impacts of other smoke exposures, including indoor and outdoor air pollution, vaping and wildfires. Decades of air pollution undermine the immune system, lymph nodes study finds Columbia University Irving Medical Center, November 23, 2022 The diminished power of the immune system in older adults is usually blamed on the aging process. But a new study by Columbia immunologists shows that decades of particulate air pollution also take a toll. The study found that inhaled particles from environmental pollutants accumulate over decades inside immune cells in lymph nodes associated with the lung, eventually weakening the cells' ability to fight respiratory infections. The findings—published Nov. 21 in Nature Medicine—offer a new reason why individuals become more susceptible to respiratory diseases with age. The Columbia researchers weren't initially looking at air pollution's influence on the immune system. More than ten years ago, they began to collect tissues from deceased organ donors to study immune cells in multiple mucosal and lymphoid tissues. Such cells have been largely inaccessible to researchers studying the immune system where sampling is limited to peripheral blood. “When we looked at people's lymph nodes, we were struck by how many of the nodes in the lung appeared black in color, while those in the GI tract and other areas of the body were the typical beige color,” says Donna Farber, Ph.D., the George H. Humphreys II Professor of Surgical Sciences at Columbia University , who led the study. And as the researchers collected more tissue from younger donors, they also noticed an age difference in the appearance of the lung's lymph nodes: Those from children and teenagers were largely beige while those from donors over age 30 looked were tinged with black and got darker with increasing age. “When we imaged the lung's blackened lymph nodes and found they were clogged with particles from airborne pollutants, we started to think about their impact on the lung's ability to fight infection as people age,” Farber says. In the new study, she and her colleagues examined tissues from 84 deceased human organ donors ranging in age from 11 to 93, all nonsmokers. They found that the pollutant particles in the lung's lymph nodes were located inside macrophages, immune cells that engulf and destroy bacteria, viruses, cellular debris, and other potentially dangerous substances. The macrophages containing particulates were significantly impaired: they were much less capable of ingesting other particles and producing cytokines—chemical “help” signals—that activate other parts of the immune system. Macrophages in those same lymph nodes that did not contain particulates were unimpaired. “We do not know yet the full impact pollution has on the immune system in the lung,” Farber adds, “but pollution undoubtedly plays a role in creating more dangerous respiratory infections in elderly individuals and is another reason to continue the work in improving air quality.” Biologist explains how cannabinoids cause tumor cells to commit suicide Compultense University (Spain): November 17, 2018 A molecular biologist from Compultense University in Madrid, Christina Sanchez, has been studying the molecular activity of cannabinoids for over a decade. Through her studies, she and colleagues found that tetrahydrocannabinol , (THC) which is the main psychoactive part of cannabis, kills tumerous cells while allowing healthy cells to be. It was an unexpected discovery when Sanchez and crew were studying brain cancer cells to grasp a better understanding of how they function. They observed that when cells were exposed to THC, the tumeral cells stopped growing then destroyed themselves. This occurred both in lab tests and animal trials. Sanchez first reported her miraculous findings back in 1998. According to Sanchez ,”After the discovery of this compound that is called THC, it was pretty obvious that this compound had to be acting on the cells, on our organism, through a molecular mechanism.” Research finds that the human body is designed to use cannabis compounds. In the eighties, research first showed the human body contains two targets for THC. One is the endocannabinoid system which processes THC through an endogenous framework. Then the various cannabinoid receptors throughout the body that use them. In conjunction, the body benefits from cannabinoids via these two natural systems. Cannabis is the only place in nature where some certain cannabinoids are found. Sanchez continues, “The endocannabinoids, together with the receptors and the enzymes that synthesize, that produce, the endocannabinoids and that degrade the endocannabinoids, are what we call the endocannabinoid system. We now know that the endocannabinoid system regulates a lot of biological functions: appetite, food intake, motor behavior, reproduction, and many, many other functions. And that's why the plant has such a wide therapeutic potential.” Cannabis cannabinoids, when consumed, work with the body's natural endocannabinoid system and bind to the receptors in the same manner as endogenous cannabinoids. The effects cancer-wise as demonstrated in animal models of breast and brain cancers is that the cancerous cells self destruct. A big advantage of cannabinoids is their unique ability to specifically target tumor cells with no effect on normal cells. This gives cannabinoids the advantage over chemotherapy which targets way more then the actual target Spending Time in the Forest or the Field: Investigations on Stress Perception and Psychological Well-Being University of Freiburg (Germany), November 16, 2022 Research suggests that stays in a forest promote relaxation and reduce stress compared to spending time in a city. The aim of this study was to compare stays in a forest with another natural environment, a cultivated field. Healthy, highly sensitive persons  aged between 18 and 70 years spent one hour in the forest and in the field at intervals of one week. The primary outcome was measured using the Change in Subjective Self-Perception (CSP-14) questionnaire. Secondary outcomes were measured using the Profile Of Mood States (POMS) questionnaire and by analyzing salivary cortisol.  The medicinal use of forests is of increasing interest worldwide. Forest air is refreshing because trees clean the air of pollutants such as nitrogen oxides and sulfur oxides, produce oxygen, and release volatile bioactive terpenes into the air . Research from Japan, South Korea], China, Taiwan, Australia, the United States, Italy, Norway, Iceland, Finland, and Austria suggests that spending time in the forest promotes relaxation, lowers stress hormones and blood pressure and strengthens the immune system. Most studies compared stays in the forest to stays in the city. Accordingly, forests potentially contribute to the prevention of stress-related diseases. Controlled studies have shown positive effects in high blood pressure, chronic heart failure, COPD and chronic neck pain. In addition, spending time in the forest seems to improve psychological well-being. Spending time in forests reduced adrenaline and noradrenaline in urine, cortisol in saliva and self-rated stress perception; it also induced relaxation in controlled trials. This indicates that forest stays can reduce stress. The available data also indicate that “forest bathing”, i.e., walking, standing or sitting in a forest with the purpose of relaxation, perceiving the environment and inhaling phytoncides stabilizes the autonomic nervous system by reducing the sympathetic and activating the parasympathetic tones. With regard to the immune system, which is linked to stress response and vegetative nerve system, an increase in the activity of natural killer cells and the expression of anti-cancer proteins such as perforin, granzyme A/B, granulysin could be demonstrated. In view of these findings, forests could make an important contribution to the prevention of stress-related diseases. As shown in previous studies, the stressful environment of a city was most often compared to a forest; it remains unclear whether forests have specific effects or are just acting as natural environments. Therefore, we wanted to compare two natural but polar-opposite environments. In cultivated fields, sensory impressions are different from the forest. In order to maximize profitability, fields are mostly structured into rectangular shapes and usually mainly one type of plant is found, while in a natural forest, different types of plants grow side by side. Accordingly, visual, auditory and olfactory impressions are less diverse in fields than in forestsThe play of light and shadow that characterizes the forest atmosphere is not found in fields. The plants are usually not tall enough to provide shade, whereas the height of the trees in the forest can provide a sense of shelter. Field paths are more often sealed than forest paths, which changes haptic perception when walking on them. Thus, there are significant differences in the types of sensory impressions between forests and fields.  Highly sensitive persons (HSP), due to their subtle perception, intensely perceive stimuli that others might not even consciously notice. These stimuli may consist of the behavior or moods of other people, the media, medications, pain, and hunger [32]. They perceive stimuli, positively or negatively, to a higher degree, which may, on the one hand, lead to a prolonged reaction time, and on the other hand to more intense feelings and emotional excitability. Our main outcome results show that, as soon as one hour after entering the forest, participants felt a sense of security, relaxation and inner connectedness. In summer, forest interventions had a better effect on vitality. Our study was the first to use the CSP-14 questionnaire, and the comparisons between field and forest interventions were also novel. Forest interventions significantly lowered perceptions of depression, anxiety, hostility, fatigue, confusion and total mood disturbance, and greatly increased vigor. This study shows that forests are not the only kind of natural environment that can promote psychological well-being. The characteristics and qualities of natural environments might influence people's mood and well-being differently. There might also be differences dependent on the preferences of the respective individuals. We regard it as meaningful to study these different effects of nature on the human soul and body in more detail. In addition, future studies examining the effects of different natural environments on human health should respect seasonal aspects and weather conditions.

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez is joined by Dr. Paolo Zola to discuss the TOTEM trial. For 20 years, Dr. Zola has been Chair of Gynaecological Oncology in the Department of Surgical Sciences of the University of Turin (Italy). Dr. Zola has conducted a large number of national and international randomized clinical trials in order to optimize the treatments for women diagnosed with gynaecological cancers. He has served as a member of the board of the EORTC Gynaecological Cancer Group and of the ESGO. Dr. Zola chairs the gynaecological cooperative group within the Oncological Network in Piedmont Region, and his research has been reported in more than 400 manuscripts published in peer reviewed literature. Highlights: - To perform the follow up in patients treated for endometrial cancer, the cornerstone is the clinical control. - In low-risk patients, surveillance every 6 months is appropriate. - In high-risk patients a clinical examination every 4 months for 2 years and then every 6 is recommended. - In addition, our data suggest taking a CT after 12 and 20 months after the primary treatment.

Pregnant women with COVID-19 are more likely to be admitted to the ICU and require invasive mechanical ventilation or venovenous extracorporeal membrane oxygenation (VV-ECMO). Nevertheless, only a few case series have focused on ventilatory management and outcomes of pregnant women with COVID-19 admitted to the ICU. COVIDPREG study primarily aimed to assess the ventilatory management of pregnant women with COVID-19 admitted to ICU. Secondly, the study aimed to evaluate obstetric management and report maternal and neonatal outcomes. Listen to Dr Mathieu Jozwiak for more insights from this study. Original paper: https://pubmed.ncbi.nlm.nih.gov/35978137/ (Management and outcomes of pregnant women admitted to intensive care unit for severe pneumonia related to SARS-CoV-2 infection: the multicenter and international COVIDPREG study) Speakers Mathieu JOZWIAK. Service de Médecine Intensive Réanimation, Centre Hospitalier Universitaire de Nice (FR). Mariangela PELLEGRINI. Intensive Care Unit, AnOpIVA, Hedenstierna Laboratory, Dept. of Surgical Sciences, Uppsala University (SE).

This episode features Dr. Khaled J. Saleh, CEO at Saleh Medical Innovations PLLC; CEO at SPHERE Orthopedics & Regenerative Health; Clinical Professor at Michigan State University Department of Surgery; & Clinical Professor Surgical Sciences at College of Medicine at Central Michigan University. Here, he discusses the importance of giving back to the community through mentorship, providing care for veterans, and more.

Idag pratar vi med Surgical Sciences vd Gisli Hennermark om kvartalsrapporten samt Securitas nya mål och satsning med analyschef Stefan Wård Disclaimer: ”Informationen i denna podd ska inte ses som investeringsråd. Tänk på att placeringar i värdepapper alltid medför en risk. Historisk avkastning är ingen garanti för framtida avkastning. De pengar som placeras i värdepapper kan både öka och minska i värde och det är inte säkert att du får tillbaka hela det insatta kapitalet. Det är viktigt att fortlöpande bevaka sitt innehav och vid behov ta initiativ till åtgärder för att minska risken för förlust.” http://www.paretosec.com/download/compliance/disclaimer.pdf

In this episode, Dr. Ijeoma Azodo, talks about her inspiration for transitioning from surgery to digital innovation and design for healthcare, as well as how NHS Education Scotland develops new projects to help improve the healthcare ecosystem. Dr. Azodo, brings together service and systems design with her expertise in surgical care, health research, and patient-centered outcomes to build digital healthcare experiences. Dr. Azodo is the Associate Director of Service Design at NHS Education Scotland technology service, an honorary clinical tutor with the Surgical Sciences at the University of Edinburgh, and a council member in the Faculty of Clinical Informatics. In this Episode 1:03 Dr. Azodo's inspiration for shifting her focus from surgery to digital innovation and design for healthcare 2:32 How her work influenced her learning and understanding of design, innovation, and technology and their roles in healthcare 4:41 The role of technology in the healthcare ecosystem of NHS Scotland 8:06 The NES Technology Design team and Dr. Azodo's responsibilities as the associate director 13:26 Essential skill sets in their line of work 14:34 The advantage of working in the NHS to the work that they do. 16:07 Fundamental shifts in patient-provider relationships 18:04 Her perspective on the trajectory of digital innovation in the healthcare space. 23:05 Developing design and technology principles centered on behavior change and equity for all patients. 25:10 The impact of design, research, and technology on the healthcare system. 29:42 How healthcare has evolved in terms of innovation throughout her career. 31:42 The future of healthcare Resources and Social Dr. Ijeoma Azodo on LinkedIn NDS Scotland website NDS Scotland on LinkedIn NDS Scotland on Twitter NHS Education for Scotland website NHS Education for Scotland on Facebook NHS Education for Scotland on Vimeo NHS Education for Scotland on Twitter NHS Education for Scotland on YouTube

In this episode of the IJGC podcast, Editor-in-Chief Dr. Pedro Ramirez is joined by Dr. Mario Preti to discuss the ESGO, ISSVD, ECSVD, and EFC consensus statements on pre-invasive vulvar lesions. Dr. Preti received his Specialization in Gynecology and Obstetrics and Specialization in Medical Oncology at the University of Torino. He is Associate Professor at the Department of Surgical Sciences, University of Torino, Italy, and the Immediate Past President of the ISSVD (International Society for the Study of Vulvo-vaginal disease). Dr. Preti is the author of 4 books on vulvo-vaginal diseases, and as of June 2022, he has published 108 papers indexed in Scopus/Pubmed, with 2,014 citations and an H-index of 23. Highlights: Epidemiological data show no decrease in vulvar invasive cancer incidence. This means that accurate diagnosis and treatment of pre-invasive vulvar disease must be improved: these are among the ESGO-ISSVD-ECSVD aims. The two carcinogenic pathways of vulvar squamous neoplasia recognize as precursors two vulvar intraepithelial neoplasia (VIN): HPV-associated squamous intraepithelial lesions (High Grade VIN) and HPV-independent VIN (mainly differentiated VIN). These precursors have different clinical approach, treatment and oncological risk. Their histologic features can be subtle, and the histological diagnosis may be further complicated by coexisting conditions. For differentiated VIN, an excisional procedure must always be adopted. Medical treatment (imiquimod or cidofovir) and ablative treatment can be considered for high grade VIN to preserve anatomy and function. These conservative approaches must be preceded by representative biopsies to exclude invasive disease. Follow up should be modulated according to the risk of recurrence (type of lesion, patient age and immunological conditions, other associated lower genital tract lesions). Pre-invasive vulvar lesions deserve specific attention because they affect not only functionality and body image, but also psychosexual factors.

Recent evidence suggests that acute hypercapnia could have harmful physiological and clinical effects in patients with ARDS, particularly impacting the haemodynamic system. A review and meta-analysis were performed to summarise the clinical consequences of acute hypercapnia in mechanically ventilated patients. The primary objective was to determine the association between acute hypercapnia and mortality in adult patients mechanically ventilated for ARDS. The secondary goal was to identify the association between acute hypercapnia and haemodynamics (systemic and pulmonary circulation) in adult patients mechanically ventilated for ARDS. Original paper: https://rdcu.be/cOdXH (The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis). Speakers: Armand MEKONTSO DESSAP. AP-HP, Hôpitaux Universitaires Henri-Mondor, Service de Médecine Intensive-Réanimation, 94010 Créteil (FR). Mariangela PELLEGRINI. Department of Surgical Sciences, Uppsala University Hospital (SE). ESICM NEXT member.

Dr Mikaela Seymour is a medical doctor working in Papua New Guinea. Over the last two years she has worked as the only doctor in some of the most remote and rural villages of Western Province PNG, accessible only by grass airstrips. During the global pandemic she was responsible for the COVID19 response and vaccine roll out. Working among a team of PNG health workers, she was responsible for maintaining primary health care, antenatal, family planning, and childhood immunisation programs, despite the challenges of the pandemic. Graduating from Griffith University in 2015 with a Masters of Medicine (MD) and Bch of Medical Science, she completed a Masters of Surgical Sciences at the University of Edinburgh, Global Surgery Course at Oxford University and Masters of Public Health and Tropical Medicine at James Cook University. She is currently completing her Global Health Engagement Grad. Cert. at USUHS. Mikaela is the founder of the Bush Dokta Subcommittee (Project Yumi Charity), connecting PNG and Australian remote health care workers, supporting grassroots health projects in Papua New Guinea. In 2018 she was awarded AMA Doctor in Training of the year due to her contributions to health care in the Western Pacific region, and 2020 Qld Young achiever for Health Care. Dr Seymour is the past deputy chair of the Australian Medical Association of Qld (AMAQ) Council of Doctors in Training, previous Chair of the Junior Medical Officer Forum of Queensland and Doctor in Training member of the Medical Workforce Advisory Committee and Medical Schools Liaison Committee for the Office of the Chief Medical Officer. During university, Mikaela was president and treasurer of the Griffith University Medical Society, secretary of the Queensland Medical Students Council, and ACRRM John Flynn Rural Scholar. Mikaela was selected for the Rural Medical Education Association (RMEA) Placement to Western Province PNG and has continued volunteering in Papua New Guinea. She has been recognized by the Lowy Institute's AUS-PNG Network as a Young Leader in the Pacific, attending the Aus-PNG Dialogue in 2017. Since then, she has been published in the Aus-PNG network blog, the Development Policy Blog Crawford Centre and the Lowy Interpreter on Pacific health issue. See omnystudio.com/listener for privacy information.

In this episode of Opera Uprising we talk about: * Libretto Creation * The Priestess of Morphine  * Voice type inclusivity * Writing for Trans Voices * Including LGBTQIA+ Stories Find out more about Aiden Feltkamp Anthology of New Music: Trans & Nonbinary Voices, Vol. 1  Website: aidenkimfeltkamp.com Twitter: @TransCherubino  Bio: Aiden K. Feltkamp (they/he) began their artistic life at the age of 5 playing a quarter-size cello and now they're "upending preconceptions about voice and gender" (New York Times) as a trans nonbinary writer.   Aiden's written work spans the serious and the ridiculous, the real and the surreal. Some of their favorite projects include: an opera with Dana Kaufman about Emily Dickinson's queerness, an interactive fiction experience about alien communication coded in Javascript (“Hello, Aria”), new English translations of Jewish lesbian erotic poet Marie-Madeleine's work (The Priestess of Morphine with Rosśa Crean), and a four-part series decoupling gender and voice types. Most recently, their work has been commissioned by Cantus, Amherst College, and the International Museum of Surgical Sciences, and has been published in Crêpe & Penn, Bait/Switch, and NewMusicBox.   Before pursuing their medical transition, Aiden performed opera professionally, specializing in Baroque opera and new music. Their most fulfilling roles include Hansel, Prince Orlofsky, Cherubino, Ottavia in L'incoronazione di Poppea (especially in a Baroque gesture production with director Drew Minter), and Elizabeth in the World and NY premieres of Griffin Candey's Sweets by Kate. They continue to train their new voice and have recently performed as Figaro in ChamberQUEER's abridged Le Nozze di Figaro.   As an equity and inclusion specialist, they consult for performing arts organizations, funders, universities, and businesses. Aiden has worked with Johnson & Johnson, Yelp, the Detroit Symphony Orchestra, OPERA America, the League of American Orchestras, and the LA Phil. Currently, they wrangle composers and arts administrators as the first-ever Director of Emerging Composers and Diversity for the American Composers Orchestra. Aiden is a Turn the Spotlight fellow (20/21 cohort), mentoring with Kathleen Kelly. As part of the fellowship, they curated New Music Shelf's Anthology of New Music: Trans & Nonbinary Voices, Vol. 1. They graduated from Bard College Conservatory's Graduate Vocal Arts Program (under the direction of Dawn Upshaw) with a Masters of Music, and received their B.S. in Vocal Performance from Hofstra University. They hold certifications in Diversity, Equity, and Inclusion (Cornell University) and Data Science (BrainStation). They currently live in Jersey City with their partner, cat, parrots, and robot dog. 

Ultrasonography is an evolving skill in critically ill patients. We provide a large number of statements regarding the required ultrasonographic basic skills for the management of critically ill patients. Original article: Speakers: https://rdcu.be/cClco (Basic ultrasound head-to-toe skills for intensivists in the general and neuro intensive care unit population: consensus and expert recommendations of the European Society of Intensive Care Medicine) Chiara ROBBA. Anesthesia and Intensive Care, Ospedale Policlinico San Martino, IRCCS per l'Oncologia e le Neuroscienze, Genoa (IT) and Department of Surgical Sciences and Integrated Diagnostics (DISC), Genoa (IT). Chair, ESICM Neuro Intensive Care Section. Adrian WONG. Department of Critical Care, King's College Hospital, London (UK). Chair, ESICM Social Media & Digital Content Committee. Antoine VIEILLARD-BARON. Intensive Care Medicine Unit, Assistance Publique-Hôpitaux de Paris, University Hospital Ambroise Paré, Billancourt, Boulogne (FR) and INSERM UMR-1018, CESP, Team Kidney and Heart, University of Versailles Saint-Quentin en Yvelines, Villejuif (FR). ESICM Secretary. Laura GALARZA. Hospital General Universitario, Castellón (ES); Chair-Elect, ESICM NEXT Committee

Introducing the awe-inspiring doctor and feminist extraodinaire, Dr. Marcella Ryan-Coker. Born, raised, and currently practicing in Sierra Leone, Dr. Ryan-Coker is an esteemed physician and global surgery advocate at the forefront of the inspirative humanitarian movement to improve surgical care in West Africa. She completed her MSc in Global Health and Development in 2018 at the University College London, and is currently completing another MSc in Surgical Sciences at the University of Edinburgh. She currently leads the International Students Surgical Network Sierra Leone National Working Group and is an active member on the Research Council of the Gender Equity Initiative in Global Surgery. Presently, Marcella has set her ambitious eyes on becoming an Orthopaedic Surgeon and we eagerly await the greatness she is destined to achieve. In this episode, we discuss the complex journey of becoming a healthcare professional in Sierra Leone, as well as some of the challenges that this country faces in terms of supplying quality emergency and surgical care for their residents. After examining some of the solutions being implemented, Marcella passionately touches on some of her own experiences working with the Ministry of Health's NGO hospitals, as well as her academic journey that evoked her passion in public health and global surgery. She stresses the importance of international agencies tailoring training and care directly to low income communities so that adequate and sustainable solutions can be brought forth. Finally, we have an important conversation regarding the intersection between gender equality and medicine, with specific regards to the barriers faced by women within this field. Marcella emphasizes the significance of having other female role models for support and guidance and she provides some advice for policy improvements that can amend gender equity in training and practice.  Dr. Ryan-Coker's Blog: https://www.scrubsscalpelshighheels.com Contact:  instagram: ott_globalsurgery twitter: OFFTHETABLE_POD email: offthetablepod21@gmail.com patreon: https://www.patreon.com/offthetablepodcast

"The Use of Ultrapotent Opioids in Veterinary Medicine," by Carrie Schroeder, DVM, DACVAA, Clinical Assistant Professor of Anesthesia and Pain Management, Department of Surgical Sciences, University of Wisconsin School of Veterinary Medicine, Madison, Wisconsin; and Dominique Keller, DVM, PhD, DACZM, Chief Veterinarian, Los Angeles Zoo, Los Angeles, California. From ASRA News, February 2021. See original article at www.asra.com/asra-news for figures and references. This material is copyrighted.    

Intriguing discussion with Christos Bergeles, the head of Robotics and Vision in Medicine Lab. It was enjoyable to discuss diverse thoughts, challenges, and limitations of Image-guided micro-surgical. I hope you find the episode informative. The Bio: Christos Bergeles received the Ph.D. degree in Robotics from ETH Zurich, Switzerland, in 2011. He was a postdoctoral research fellow at Boston Children’s Hospital, Harvard Medical School, Massachusetts, and the Hamlyn Centre for Robotic Surgery, Imperial College, United Kingdom. He was an Assistant Professor at the Wellcome/EPSRC Centre for Interventional and Surgical Sciences (which he co-founded) at University College London. He is now a Senior Lecturer (Associate Professor) at King's College London, leading the Robotics and Vision in Medicine Lab. Dr. Bergeles received the Fight for Sight Award in 2014, and the ERC Starting Grant in 2016. His main research area is image-guided micro-surgical robotics.

INTERVIEWS IN THIS EDITION: Physical Therapy Management of Children With Developmental Coordination Disorder: An Evidence-Based Clinical Practice Guideline From the Academy of Pediatric Physical Therapy of the American Physical Therapy Association First Evidence Based Clinical Practice Guideline for physical therapy management of childhood Developmental Coordination Disorder. Lisa Dannemiller tells clinicians how to use it, and talks about the benefits it can bring. Lisa Dannemiller PT, DSC, PCS, Associate Professor, Physical Therapy, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA Associations Between Congenital Muscular Torticollis Severity and Physical Therapy Episode Congenital muscular torticollis: Kathryn Knudsen talks about the associations her research found between the severity of congenital muscular torticollis and the use of physical therapy to treat it. Kathryn C R Knudsen PT, MPT, PCS, CNT, Providence Children’s Development Institute, Portland, OR, USA Experiences of Parents of Infants Diagnosed With Mild and Severe Grades of Congenital Muscular Torticollis Magdalena M Oledzka described findings and implications from her group’s comparison of the experiences reported by parents of infants diagnosed with congenital muscular torticollis at levels of severity ranging from mild to severe. Magdalena M Oledzka PT DPT MBA PCS, Director of Pediatric Rehab, Hospital for Special Surgery, New York Changes in Vestibular/Ocular-Motor Screen Scores in Adolescents Treated With Vestibular Therapy After Concussion The usefulness of the recently-developed Vestibular/Ocular-Motor Screen Score (that primarily measures dizziness) has been investigated for assessing recovery from concussion in adolescents. First author Bara Alsalaheen discusses the findings and clinical implications. Bara Alsalaheen PT, PhD, Departments of Physical Therapy & Neurology, University of Michigan-Flint, Flint, Michigan Sternal Precautions and Prone Positioning of Infants Following Median Sternotomy: A Nationwide Survey Findings on how to optimize physical therapy in children who’ve had chest surgery are reported by Amanda Clifton from her group’s research on the precautions needed when managing infants after sternal surgery. Amanda Clifton PT, DPT, Nicklaus Children’s Hospital, Miami FL “Contemporary Practice as a Board-Certified Pediatric Clinical Specialist: A Practice Analysis” The results of an analysis of current practice among board-certified pediatric clinical specialists are discussed by researcher Lisa Kenyon. Key knowledge areas, professional roles, and responsibilities were surveyed among 323 professionals as practiced in real-world settings. Kenyon explains how the new evidence informs revision of the Description of Specialty Practice—DSP—for pediatrics—the blueprint for maintaining  and improving training quality.  Lisa Kenyon PT, DPT, PhD, PCS, Associate Professor, Dept of Physical Therapy, Grand Valley State University, Grand Rapids, Michigan Sedentary Behavior in Children With Cerebral Palsy Between 1.5 and 12 Years: A Longitudinal Study Sarah Reedman talks about her findings on sedentary behavior among children with cerebral palsy as a health risk factor and as a guide to management. Sarah E Reedman PT, PhD, QCPRRC, Centre for Children’s Health Research, in South Brisbane, Queensland, Australia Measurement Properties of the Dizziness Handicap Inventory—Children and Adolescents for Children and Adolescents Postconcussion The Dizziness Handicap Inventory scoring system has been researched by a team lead by Devashish Tiwari as a means of assessing recovery from concussion among children and adolescents.  Devashish Tiwari DPT, PhD, NCS, Department of Physical Therapy, Simmons University, Boston, MA Intraobserver Reliability and Construct Validity of the Squat Test in Children With Cerebral Palsy Researcher Maaike Eken talks about her findings comparing the quick and easy “squat test” with the more conventional dynamometer for checking development in children with cerebral palsy. Maaike Eken PhD, Department of Rehabilitation Medicine, Amsterdam University Medical Centers, Amsterdam, Netherlands, Department of Surgical Sciences, Faculty of Stellenbosch University, Tygerberg Campus, Tygerberg, South Africa,

I am in conversation with Dr Ian Tenant, a wellbeing specialist helping people make inexpensive and simple choices that improve their health. With a doctorate from The University of Edinburgh in Clinical and Surgical Sciences and qualifications in sports massage and holistic lifestyle coaching, Ian works with knowledge on the frontiers of medical research to help his clients feel more energised and understand why the habits of healthy people actually work. Ian has previously worked as a researcher at the Medical Research Council Centre for Inflammation Research, but now helps clients face-to-face with health issues, including professional athletes and high-level entrepreneurs.----more---- Ian has risen to conquer his own personal health challenges too, putting chronic digestion and sinus issues into long-term remission and learning how to manage a heart condition whilst still maintaining high levels of physical activity. We cover a lot of ground in the discussions, all based around Ian’s book called Restoring Balance. He presents a fantastic simple and accessible framework that we can use when assessing and working to improve our personal health. The framework contains six polarities, with the idea that we must individually work to find a state of balance that feels good for us inside each set of polarities. We break down the whole framework in our podcast, discussing the polarities of light/dark, feasting/fasting, connection/independence, movement/stillness, technology/nature and excitement/calmness. Ian tells us why each of these polarities matter, how they work and what you can do to restore your own sense of balance. Trying to live a healthy life can seem so complicated, as we are bombarded by so much modern information about improving wellbeing. What I love about Ian’s framework is that it’s refreshingly simple with a big picture approach. Whichever direction you travel in life, equipped with Ian’s six polarities model you should have a solid platform to grow and prosper.   Enjoy & Peace    The mission: Second Mind empowers you to become the greatest version of yourself and better our world. To ignite personal growth and intrigue your mind, we showcase the journeys, ideas and mindsets of inspiring people. We broadcast guests who live and think differently to create positive change for planet Earth. Their messages will challenge your perspectives and give you the fuel to master your potential.   Don’t miss our regular episodes, hit subscribe or follow to see new releases.   FOLLOW SECOND MIND: Facebook: https://www.facebook.com/secondmind365/ Twitter: https://twitter.com/secondmind365   Instagram: https://www.instagram.com/secondmind365/   YouTube (w/video): https://www.youtube.com/channel/UCuq8qBjHyQBsuzB_y4SKWoA iTunes : https://podcasts.apple.com/gb/podcast/second-mind/id1480389830 Spotify: https://open.spotify.com/show/4IRdfj0CkzK0BeC5WUZKRA?si=HI2ZRTklTsm4AJ831pbS3Q    Google podcasts: https://playmusic.app.goo.gl/?ibi=com.google.PlayMusic&isi=691797987&ius=googleplaymusic&apn=com.google.android.music&link=https://play.google.com/music/m/Ix6f3niy3hr6xmod664mx5lg4lu?t%3DSecond_Mind%26pcampaignid%3DMKT-na-all-co-pr-mu-pod-16 …or search ‘Second Mind’ wherever you get your podcasts.   FOLLOW DR IAN TENNANT: Facebook: https://www.facebook.com/ThriveAndEnjoy/ Website and Restoring Balance book: https://restoringbalance.life/    

On Episode 11, I interview Dr. Tinashe Chandauka. He is a Doctor, a Rhodes Scholar and a Venture Capitalist Associate.Tinashe was born in Zimbabwe and was educated there for primary school before moving to South Africa for high school. He was Head Boy of St Stithians Boys' College in 2007. He studied a Bachelor of Medicine and Surgery (MBChB) at the University of Cape Town. He went on to do a DPhil (PhD) in Surgical Sciences at the University of Oxford in the United Kingdom (and he has just submitted his PhD).Tinashe and I will speak on the following in Episode 11:Becoming a South African - with particular context to his journey and experiences in the transition from Zimbabwe to South Africa, studying at UCT and his journey at Oxford University.Building a Tech-Enabled South African Economy - and the challenges we face in this light.Our Shared Vision for what South Africa can Become - and the roles that different parts of society can play in shaping that visionSubscribe and give us a review!To find out more about Impactful Conversations, head over to our website: https://www.impactfulconversations.co.za/

Dr Helen Higham delivers a talk on the human factors approach to incident analysis. Dr Helen Higham is Consultant Anaesthetist at Oxford University Hospitals NHS Foundation Trust, Director of OxSTaR, the University of Oxford's Simulation Centre, and co-director of the Patient Safety Academy at the Nuffield Department of Surgical Sciences.

Dr Helen Higham delivers a talk on the human factors approach to incident analysis. Dr Helen Higham is Consultant Anaesthetist at Oxford University Hospitals NHS Foundation Trust, Director of OxSTaR, the University of Oxford’s Simulation Centre, and co-director of the Patient Safety Academy at the Nuffield Department of Surgical Sciences.

PRESS RELEASE: Overall survival in patients with lung adenocarcinoma harboring “niche” mutations: an observational study The cover for issue 5 of Oncotarget features Figure 2, "Survival curves in the KRAS, EGFR, and niche mutations cohorts," by Aramini, et al. Mutations were observed in all genes studied, except c-MET, DDR2, MAP2K1, and RET. The multivariable analysis showed that: Niche mutations had higher mortality than EGFR mutations KRAS mutations had higher mortality than EGFR mutations, and Niche mutations presented similar mortality to KRAS mutations. Niche mutations exhibited an increased risk of death when compared with EGFR mutations and a similar risk of death when compared with KRAS mutations. Dr. Beatrice Aramini from the Division of Thoracic Surgery in Department of Medical and Surgical Sciences at the University of Modena and Reggio Emilia in Modena Italy said in their Oncotarget Research Paper, "In the last century, carcinoma of the lung has progressed from an uncommon and obscure disease to the most common cancer in the world, and the most common cause of death from cancer." In addition to these somatic mutations, which are the most frequent, other mutations in several genes have been discovered, including BRAF, c-MET, DDR2, HER2, MAP2K1, NRAS, PIK3CA, and RET mutations. Moreover, the prevalence of the RET mutation in adenocarcinoma was estimated to be 1.7%, and the prevalence of DDR2 mutation in lung cancer was 2.2%. With regard to treatment, discoveries of gene mutations have allowed the development of targeted therapies, which are considered more effective for survival than chemotherapy in patients with advanced mutated disease. Considering the potential aggressiveness of niche mutations in this context, the technological advances of next-generation sequencing, which is currently used in clinical practice, represents a precise approach to identifying a large panel of mutations in oncologic patients. The Armini Research Team concluded, "The correct selection of mutations will be helpful in terms of the greater efficacy of treatment in association with better prognosis and a higher quality of life for oncologic patients." Full text - https://doi.org/10.18632/oncotarget.27472 Correspondence to - Beatrice Aramini,beatrice.aramini@unimore.it Keywords - somatic mutations, non-small cell lung cancer (NSCLC), lung cancer treatment, overall survival, target therapy Sign up for free Altmetric alerts about this article About Oncotarget Oncotarget is a weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit http://www.oncotarget.com or connect with: YouTube - http://bit.ly/OncotargetYoutube SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact 18009220957x105 MEDIA@IMPACTJOURNALS.COM

Oncotarget interviews Dr. Beatrice Aramini from the University of Modena and Reggio Emilia in Modena Italy about their Featured Cover Paper for Volume 11 Issue 5 titled "Overall survival in patients with lung adenocarcinoma harboring “niche” mutations: an observational study" PRESS RELEASE: The cover for issue 5 of Oncotarget features Figure 2, "Survival curves in the KRAS, EGFR, and niche mutations cohorts," by Aramini, et al. Mutations were observed in all genes studied, except c-MET, DDR2, MAP2K1, and RET. The multivariable analysis showed that: Niche mutations had higher mortality than EGFR mutations KRAS mutations had higher mortality than EGFR mutations, and Niche mutations presented similar mortality to KRAS mutations. Niche mutations exhibited an increased risk of death when compared with EGFR mutations and a similar risk of death when compared with KRAS mutations. Dr. Beatrice Aramini from the Division of Thoracic Surgery in Department of Medical and Surgical Sciences at the University of Modena and Reggio Emilia in Modena Italy said in their Oncotarget Research Paper, "In the last century, carcinoma of the lung has progressed from an uncommon and obscure disease to the most common cancer in the world, and the most common cause of death from cancer." In addition to these somatic mutations, which are the most frequent, other mutations in several genes have been discovered, including BRAF, c-MET, DDR2, HER2, MAP2K1, NRAS, PIK3CA, and RET mutations. Moreover, the prevalence of the RET mutation in adenocarcinoma was estimated to be 1.7%, and the prevalence of DDR2 mutation in lung cancer was 2.2%. With regard to treatment, discoveries of gene mutations have allowed the development of targeted therapies, which are considered more effective for survival than chemotherapy in patients with advanced mutated disease. Considering the potential aggressiveness of niche mutations in this context, the technological advances of next-generation sequencing, which is currently used in clinical practice, represents a precise approach to identifying a large panel of mutations in oncologic patients. The Armini Research Team concluded, "The correct selection of mutations will be helpful in terms of the greater efficacy of treatment in association with better prognosis and a higher quality of life for oncologic patients." Full text - https://doi.org/10.18632/oncotarget.27472 Correspondence to - Beatrice Aramini,beatrice.aramini@unimore.it Keywords - somatic mutations, non-small cell lung cancer (NSCLC), lung cancer treatment, overall survival, target therapy Sign up for free Altmetric alerts about this article About Oncotarget Oncotarget is a weekly, peer-reviewed, open-access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit http://www.oncotarget.com or connect with: YouTube - http://bit.ly/OncotargetYoutube SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact 18009220957x105 MEDIA@IMPACTJOURNALS.COM

The talk focusses on kidney preservation with Mr Simon Knight talking about some of the clinical research that has been done, while Mr James Hunter discusses their translational and lab research. Mr Simon Knight and Mr James Hunter are both Senior Clinical Research Fellows at the Nuffield Department of Surgical Sciences, University of Oxford.

The talk focusses on kidney preservation with Mr Simon Knight talking about some of the clinical research that has been done, while Mr James Hunter discusses their translational and lab research. Mr Simon Knight and Mr James Hunter are both Senior Clinical Research Fellows at the Nuffield Department of Surgical Sciences, University of Oxford.

Episode 76: Dr. John Petty and Dr. Marion Henry  This week we have a special episode on gun violence. The American Pediatric Surgical Association has just released a statement on firearm injuries and children. It reads, in part,: Firearm injuries are the second most common cause of death in children who come to a trauma center, and pediatric surgeons provide crucial care for these patients. The American Pediatric Surgical Association (APSA) is committed to comprehensive pediatric trauma readiness, including firearm injury prevention. APSA supports a public health approach to firearm injury.” Our guests today are Dr. John Petty, associate professor of Surgical Sciences in Pediatrics at Wake Forest Baptist Hospital and Dr. Marion Henry, an associate professor of Surgery and Pediatrics at the College of Medicine at the University of Arizona. These two doctors were instrumental drafting this new statement.

Professor Peter Friend, Dr David Nasralla and Dr Carlo Ceresa discuss liver transplantation and why they are replacing conventional cold storage in an ice box with normothermic automated, transportable liver preservation. Professor Peter Friend is Professor of Transplantation at the Nuffield Department of Surgical Sciences, and Dr David Nasralla and Dr Carlo Ceresa are Clinical Research Fellows in Transplant Surgery at NDS, University of Oxford. This research has been published in the journal Nature. Please visit: https://www.nature.com/articles/s41586-018-0047-9

Professor Peter Friend, Dr David Nasralla and Dr Carlo Ceresa discuss liver transplantation and why they are replacing conventional cold storage in an ice box with normothermic automated, transportable liver preservation. Professor Peter Friend is Professor of Transplantation at the Nuffield Department of Surgical Sciences, and Dr David Nasralla and Dr Carlo Ceresa are Clinical Research Fellows in Transplant Surgery at NDS, University of Oxford. This research has been published in the journal Nature. Please visit: https://www.nature.com/articles/s41586-018-0047-9

Professor David Cranston takes us on a little trip through art and medicine using illustrations of works that portray the changing role of medicine in society. David Cranston is Associate Professor of Surgery at the Nuffield Department of Surgical Sciences, University of Oxford.

In the first half, Dr Alastair Lamb discusses the problem with prostate cancer and what it is that needs to be addressed, his previous research and future plans for research. In the second half, he talks about clinical activity; robotic surgery, changing the paradigm of how patients are selected for surgery, and the use of media to get the message across. Dr Alastair Lamb is a Senior Fellow in Robotic Surgery and Honorary Consultant Urologist at the Nuffield Department of Surgical Sciences, University of Oxford.

Professor Peter McCulloch and Dr Tinashe Chandauka talk about improving surgery in Africa and designing a surgical safety education programme. Professor Peter McCulloch is head of the Quality, Reliability, Safety and Teamwork Unit at the Nuffield Department of Surgical Sciences and Dr Tinashe Chandauka is a DPhil in Surgical Sciences scholar at the University of Oxford.

James Gilbert and Dr Simon Knight give an update on vascular access and some of the innovations that are going on in vascular access surgery. Mr James Gilbert is a Consultant Transplant and Vascular Access Surgeon at Oxford University Hospitals NHS Foundation Trust and Dr Simon Knight is an Honorary Consultant Transplant and Access Surgeon and Senior Clinical Research Fellow at the Nuffield Department of Surgical Sciences, University of Oxford.

Professor Peter McCulloch and Dr Lauren Morgan talk about investigating serious surgical incidents and how human factors science can help us. Professor McCulloch is Head of the Quality, Reliability, Safety and Teamwork Unit (QRSTU) in Oxford University’s Nuffield Department of Surgical Sciences and Dr Lauren Morgan is a Lecturer and Researcher in Human Factors within QRSTU.

Professor Byrne showcases the work of the Oxford Neurovascular and Neuroradiology Research Unit. Professor James Byrne is Professor of Neuroradiology at the Nuffield Department of Surgical Sciences, Oxford University.

Professor Peter McCulloch, Dr Lauren Morgan and Ms Lorna Flynn discuss patient safety and the work of the Quality, Reliability, Safety and Teamwork Unit (QRSTU). Dr Morgan is Lecturer and Researcher in Human Factors, Ms Flynn is a Human Factors Research Assistant, and Professor McCulloch is Professor of Surgical Science and Practice, and head of the QRSTU at the Nuffield Department of Surgical Sciences, University of Oxford.

Mr Radu Mihai and Dr Peter Hambly give a talk about rare/never events in surgery. Treating rare diseases raise the challenge of minimal previous exposure to similar operations. Defining a learning curve is therefore controversial as many such 'events' seem to occur in clusters. Similarly, rare complications might occur in 'clusters' hence the response to rare/never events should be interpreted with caution. Mr Mihai is a Consultant Endocrine Surgeon and Dr Hambly is a Consultant Anaesthetist at Oxford University Hospitals NHS Foundation Trust. Mr Mihai is also an Honorary Senior Clinical Lecturer at Nuffield Department of Surgical Sciences, University of Oxford.

Professor Tipu Aziz and Dr Binith Cheeran talk about deep brain stimulation (DBS) for treating intractable pain syndromes. Professor Halliday is Professor of Neurosurgery at the Nuffield Department of Surgical Sciences and Dr Cheeran is an Honorary Consultant Neurologist at the Nuffield Department of Clinical Neurosciences at the University of Oxford.

Professor Alison Halliday presents ‘Vascular trials, big data and dementia’ and Professor Linda Hands presents ‘Community leg ulcer clinics and telemedicine’. Professor Halliday is Professor of Vascular Surgery and Professor Hands is Associate Professor of Surgery at the Nuffield Department of Surgical Sciences at the University of Oxford.

Dr Elmi Muller talks about HIV positive donors for HIV positive recipients and changing transplant practices around the world. Dr Muller is a general surgeon and is the head of the transplantation service at Groote Schuur Hospital in Cape Town, South Africa. She joined the Transplantation Research Immunology Group at the Nuffield Department of Surgical Sciences for three months until January 2016, having successfully secured a Newton International Exchange scheme award.

Mission Statement: Kennedy Professional Educational Seminars is committed to providing high quality, clinically oriented continuing dental education in outstanding holiday settings.   Dr. Jack Lipkin, BSC, DMD: Dr. Lipkin obtained his Bachelor of Science from the University of Manitoba in 1970, and his D.M.D. from the University of Manitoba in 1974. In 1979, Dr. Lipkin received his certificate of Fixed Prosthodontics from the State University of New York at Buffalo, New York. He is a full time private practitioner and has practiced as a prosthodontist since 1979.   Dr. Lipkin is an assistant professor in the Department of Dental Diagnostic and Surgical Sciences, Faculty of Dentistry University of Manitoba. Dr. Lipkin is Vice President of the American Academy of Fixed Prosthodontics. He is a member of the Association of Prosthodontists of Canada, the Canadian Dental Association, the International College of Prosthodontists, the Academy of Osseointegration and is a fellow of the Pierre Fauchard Academy and the International College of Dentists.   Kennedy Seminars: Kennedy Professional Educational Seminars Inc., was started in 1993 by Dr. Marshall Hoffer and Dr. Jack Lipkin, as a natural continuation of their involvement in dental continuing education. The origins of Kennedy Professional Educational Seminars, Inc. arose from the Winnipeg Prosthodontic Study Club, an active dental study club started in 1981, which sponsored lectures by many top dental clinicians and academics.   The concept of combining high quality programs presented in conjunction with exciting holiday venues led to the formation of Kennedy Professional Educational Seminars, Inc. Our goal is to provide a selection of clinically relevant continuing education programs, hosted in a variety of holiday oriented locations. These programs are scheduled through the year so that a suitable subject and location should be available to most practicing dentists.   www.kennedyseminars.com

Punk Professor. Space pirate. Design rebel. Noah Scalin is not your ordinary guy ~ he might not even sleep! He teaches design at the Virginia Commonwealth University, runs a socially conscious design firm called Another Limited Rebellion, and has just launched a kickstarter campaign for a new book of skulls that you’ll want to hear all about. We had so much to talk about that this show is just part one of a two part interview. Noah’s work can be seen in many publications including USA Today, Wired and The New York Times. His art has been exhibited at the Mütter Museum in Philadelphia, the Museum of Death in Hollywood, The International Museum of Surgical Sciences in Chicago, and the Museum of World Culture in Gothenberg, Sweden. He gets around. Noah has written a series of books on creativity, made skulls with Martha Stewart on her TV show, and even found time to meet me in his Richmond studio. We had so much to talk about that this show is just part one of a two part interview.

Professor Dirk De Ridder's Inaugural Professorial Lecture. Tuesday, 24 September 2013.

Professor Dirk De Ridder's Inaugural Professorial Lecture. Tuesday, 24 September 2013.

Professor Dirk De Ridder's Inaugural Professorial Lecture. Tuesday, 24 September 2013.

Professor Dirk De Ridder's Inaugural Professorial Lecture. Tuesday, 24 September 2013.

"Surgical waiting lists: are patients getting a fair go?" Professor Jean-Claude Theis' Inaugural Professorial Lecture, 27 November 2012. Professor Theis:, Department of Surgical Sciences, Dunedin School of Medicine

"Surgical waiting lists: are patients getting a fair go?" Professor Jean-Claude Theis' Inaugural Professorial Lecture, 27 November 2012. Professor Theis:, Department of Surgical Sciences, Dunedin School of Medicine

"Surgical waiting lists: are patients getting a fair go?" Professor Jean-Claude Theis' Inaugural Professorial Lecture, 27 November 2012. Professor Theis:, Department of Surgical Sciences, Dunedin School of Medicine

"Surgical waiting lists: are patients getting a fair go?" Professor Jean-Claude Theis' Inaugural Professorial Lecture, 27 November 2012. Professor Theis:, Department of Surgical Sciences, Dunedin School of Medicine