The EMJ Podcast: Insights For Healthcare Professionals

In this inspiring episode of Hema Now, Catherine Glass speaks with Rob Pieters, Professor of Pediatric Oncology at Utrecht University; and co-founder of the Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands, the largest dedicated childhood cancer centre in Europe. Pieters shares his personal journey in paediatric oncology, the breakthroughs that have reshaped care, and the vision behind uniting all of the Netherlands' childhood cancer expertise under one roof.  Timestamps   00:00 – Introduction  01:06 – Pieters' start in paediatric oncology  01:29 – Biggest breakthroughs in childhood cancers  02:35 – Parts of Pieters work that bring him the most joy  03:12 - Lessons learnt from patients or their families   04:31 – The vision behind the Princess Máxima Center  08:35 – The impact of the Princess Máxima Center   10:53 – How is research funding divided?  12:55 – Evolution of treatments in paediatric oncology  15:10 – What will it take to achieve 100% cure rate in acute lymphoblastic leukaemia?  18:55 – President Elect of the European Society for Paediatric Oncology (SIOPE)  22:20 – One message of hope to families facing childhood cancer  25:10 – Pieter's three wishes for healthcare 

Pérez Marc discusses complementary RSV prevention strategies, including maternal vaccines and long-acting monoclonals. Learn about health system decision-making, cost-effectiveness, lessons from COVID-19, and the potential for RSV to become a vaccine-preventable disease. Timestamps: 00:00 - Introduction 00:44 – RSV vaccine in routine antenatal care 04:22 – Dual strategy: vaccine and monoclonals 08:25 – Pandemic versus endemic 13:46 – Will RSV become vaccine-preventable? 15:02 – Final message for healthcare professionals

Maternal vaccination is a key tool in preventing RSV. Perez Marc discusses the BERNI study, its design, findings on safety and neonatal protection, real-world effectiveness, vaccine equity, ethical considerations, and global integration strategies. Timestamps: 00:00 – Introduction 00:47 – Why maternal immunisation in RSV? 02:02 – The BERNI study 07:24 – The vaccine's real-world impact 11:50 – Vaccine equity: a key challenge 12:57 – Ethical issues in maternal immunisation

In this first deep dive episode, Gonzalo Pérez Marc joins Saranya Ravindran to explore the global burden of RSV. Learn about hospitalisation and mortality rates, myths, seasonal changes, and long-term respiratory consequences. This episode highlights the urgent need for awareness and policy action in paediatric care. Timestamps: 00:00 – Introduction 00:44 – Pérez Marc's journey into RSV research 03:14 – Why RSV is not just a ‘common cold' 05:47 – Mortality in newborns and infants 06:55 – Why is RSV still underestimated? 09:51 – The impact of climate change 12:37 – RSV and long-term lung disease 15:01 – Pathophysiology of RSV 16:08 – Debunking RSV myths

In this quickfire episode, Gonzalo Pérez Marc answers key questions about RSV in infants, from overlooked risks and seasonality to public health priorities and maternal vaccine insights. Perfect for listeners short on time but eager to boost their RSV knowledge in just a few minutes.

In the final instalment, Stephanie Rutledge explores alcoholic hepatitis and long-term mental wellness. Covering acute clinical crises, experimental therapies, and future treatment guidelines, she highlights how hepatology can better integrate mental health and substance use care to transform patient outcomes.  Timestamps:  0:33 – Acute alcoholic hepatitis  3:08 – Patients with alcohol use disorder  4:32 – Medical advancements  6:25 – Prevention  10:45 – Current research  13:01 – Advice for young clinicians 

What happens when alcohol use and metabolic factors collide? In Part 2, Stephanie Rutledge explains how alcohol-related liver disease develops, the challenges of holistic care, and the evolving role of liver transplantation. A must-listen for clinicians navigating the complexities of metabolic dysfunction and alcohol-related liver disease, and patient-centred management.  Timestamps:  0:21 – Metabolic dysfunction and alcohol-related liver disease (MetALD)  3:45 – Treatments for liver disease  5:49 – Mental health considerations  6:36 – Family support  7:51 – Factors beyond clinical treatment 

Tolaney focuses on advancing breast cancer treatment through innovative clinical research. She has been instrumental in developing novel therapies and leading key clinical trials, particularly for early-stage HER2-positive breast cancer.     Timestamps   00:09 – Introduction  01:12 – What is HER2-positive breast cancer?  03:00 – Key trials Tolaney has led  07:16 – Antibody-drug conjugates  12:00 - Breast Oncology Guidelines  14:51 – Treatment optimisation   18:27 – Equity in healthcare  21:10 – Mentoring the next generation of oncologists  22:52 – Tolaney's wishes for healthcare 

Stephanie Rutledge joins host Saranya Ravindran to unpack the mental health dimensions of alcohol use disorder. From co-occurring conditions and behavioural strategies like motivational interviewing to the role of family and community support, this episode explores how integrated care can strengthen recovery.  Timestamps:  1:44 – Why hepatology  3:25 – Genetic factors  4:18 – Alcohol use disorder interventions  5:58 – Motivational interviewing  7:25 – Motivational interviewing skills  8:34 – Beyond clinical settings  10:49 – Alcohol use disorder therapy 

In this rapid-fire episode, Stephanie Rutledge answers key questions on alcohol in hepatology, from mental health challenges in alcohol use disorder to transplant misconceptions, emerging therapies, and the impact of lifestyle changes like Dry January. It provides a concise, insightful overview in just minutes.  Timestamps:  1:08 – Treating alcohol use disorder  1:33 – Technique for alcohol use disorder recovery  1:50 – Misconceptions  2:14 – Psychosocial factors  2:32 – Alcohol use disorder and liver transplantation  2:50 – Experimental education  3:09 – Dry January and sober October  3:35 – Mental health  3:53 – Halting disease progression  4:14 – Liver transplantation  4:46 – Breakthrough therapies 

This podcast and accompanying promotional content has been created in collaboration with and funded by  Biogen. This information is intended for healthcare professionals. The presented content includes mentions of the Skyclarys▼ (omaveloxolone) EU-approved label. Prescribing information for omaveloxolone can be found here. Friedreich's ataxia (FA) is a rare genetic disease that can affect children and adults and cause progressive neurodegeneration, loss of physical function, multiple comorbidities, and even premature death. In this episode, two well renowned experts, Dr Louise Corben and Dr Wolfgang Nachbauer discuss the diagnostic journey for patients with FA, disease progression and the importance of working with multidisciplinary teams in the development of management strategies.

In the final episode, Debby Bogaert discusses how cutting-edge microbiome science is being translated into practice. From novel vaccine approaches to strategies that support the developing microbiome, this conversation highlights how research can drive new preventive solutions to reduce pneumococcal disease and promote healthier lives for children everywhere.  0:30- Mucosal Vaccines  2:02 - Rotavirus Vaccine  2:49- Microbiome Science Policy  4:22- Ethics in Infant Microbiome  6:35- Final Message 

In part two, Debby Bogaert unpacks her pioneering research on the infant respiratory microbiome. Discover how early microbial communities in the airways influence immunity, infection risk, and long-term respiratory health — and why nurturing the microbiome could play a critical role in disease prevention.  0:38- Microbiome and Resilience Against Infection  1:57- Microbiome in Healthy Infancy  3:00- Respiratory Microbiome and Inflammation  4:31- Benefits of Commensal Bacteria   6:39- Microbiome-Based Diagnostics  7:55- Pre and Post Biotics  10:03- Day-to-Day Practice 

In this episode, host Jonathan Sackier is joined by Andrew Dunbar, Assistant Professor in the Department of Hematopoietic Biology and Malignancy at the University of Texas MD Anderson Cancer Center, Houston, USA. Dunbar discusses his research into myeloproliferative neoplasms, what drives disease progression and resistance, and promising targets for treatment, while reflecting on the mission of his lab and what lies ahead for the field.  Timestamps  00:00 – Introduction  02:29 – One thing people should know about myeloproliferative neoplasms  05:01 – Dunbar's background and research focus  08:00 – What would Dunbar do if not science and medicine?  10:24 – The basics of myeloproliferative neoplasms  14:30 – Myeloproliferative neoplasm diagnosis and treatment  16:49 – What drives disease progression and resistance?  18:30 – The mission of Dunbar's lab  21:23 – Development of AJ1-11095  22:54 – Balancing the complexity of disease modelling with urgent clinical needs  24:03 – Promising targets and pathways  26:35 – What's on the horizon?  28:40 – Three wishes 

In this first deep dive, Debby Bogaert explores the global burden of pneumococcal disease in young children and compares its impact with RSV and flu. She discusses how pneumococcus colonises the respiratory tract, the role of co-infections, and the importance of vaccination. Listeners will also learn how early life factors and microbiome recovery shape the infant respiratory ecosystem. Timestamps: 0:42- Pneumococcus in Young Children 2:46- Global Burden of Pneumococcal Disease 4:15- Pneumococcus vs RSV and Flu 7:17- Microbiome Recovery 8:29- Pneumococcal Vaccination 9:46- Role of Co-Infections 11:34- Colonisation 13:30- Respiratory Tract As an Ecosystem 15:44- Early Life Factors  

Get to know Debby Bogaert in this fast-paced quickfire round. She shares the most overlooked aspect of pneumococcal disease, clears up common misconceptions, and reveals the biggest surprise from her research. From advice for new parents to public health leaders, this bite-sized episode is packed with insights Timestamps: 2:14- Overlooked aspect of pneumococcal disease 2:37- Infant Microbiome 2:50- One Misconception 3:04- Biggest Surprise 3:26- Message to New Parents 3:54- Advice to Public Health Leaders

In this episode, host Saranya Ravindran is joined by Toby Maher to explore the often-overlooked world of interstitial lung diseases. From clarifying common misconceptions to highlighting AI innovations and personalised treatments, the series dives deep into what clinicians need to know about these serious lung conditions. Whether you're new to interstitial lung diseases or experienced in respiratory care, this series offers timely insights and expert takeaways. Timestamps: 00:00: Introduction 00:40: Mainstays of treatment 04:42: Limitations of current antifibrotics 07:50: The future of ILD personalised care 13:40: Are we close to the reversal of fibrosis? 15:52: A message for clinicians

In this episode, host Saranya Ravindran is joined by Toby Maher to explore the often-overlooked world of interstitial lung diseases. From clarifying common misconceptions to highlighting AI innovations and personalised treatments, the series dives deep into what clinicians need to know about these serious lung conditions. Whether you're new to interstitial lung diseases or experienced in respiratory care, this series offers timely insights and expert takeaways. Timestamps: 00:00: Introduction 00:41: Challenges in early diagnosis 03:22: ILD biomarkers 05:49: The overlap with autoimmune diseases 09:16: AI in ILD detection

In this episode, host Saranya Ravindran is joined by Toby Maher to explore the often-overlooked world of interstitial lung diseases. From clarifying common misconceptions to highlighting AI innovations and personalised treatments, the series dives deep into what clinicians need to know about these serious lung conditions. Whether you're new to interstitial lung diseases or experienced in respiratory care, this series offers timely insights and expert takeaways. Timestamps: 00:00: Introduction 02:00: ILD landscape: UK versus USA 04:33: What falls under the ILD umbrella? 06:38: Idiopathic pulmonary fibrosis 07:58: Understanding different patient profiles 09:28: Early clinical signs of ILD

In this episode, host Saranya Ravindran is joined by Toby Maher to explore the often-overlooked world of interstitial lung diseases. From clarifying common misconceptions to highlighting AI innovations and personalised treatments, the series dives deep into what clinicians need to know about these serious lung conditions. Whether you're new to interstitial lung diseases or experienced in respiratory care, this series offers timely insights and expert takeaways.

In this episode of Onc Now, host Jonathan Sackier welcomes Komal Jhaveri, Breast Medical Oncologist and clinical investigator at Memorial Sloan Kettering Cancer Center, New York, USA. Known for her trailblazing work in HER2-positive, HER2-low, and hormone receptor-positive breast cancers, Komal Jhaveri discusses how molecular subtyping, antibody-drug conjugates, and precision trials are reshaping the field.     Timestamps  00:00 – Introduction  02:50 – What initially drew Komal into oncology   04:45 – The future of breast cancer care  06:13 – Possibility of personalised treatments for patients  07:40 – Antibody-drug conjugates  09:30 – How we define HER2 status  14:40 – HER2-low disease  17:40 – Targeted therapy combinations  20:54 – Endocrine resistance  23:18 – The realities of implementing new therapies   28:40 – Promising initiatives on the horizon  31:30 – Komal's key takeaways  

In the final episode of this series on preventative medicine, Vinod Patel discusses how integrated care models, professional training, and patient education improve diabetes outcomes. From chronic fatigue clinics to national screening programs, this episode highlights how innovation in education and collaboration can transform diabetes care across systems.  Timestamps: 00:40 – Clinical care  02:12 – Chronic Fatigue Clinic  03:52 – Lipid management   05:42 – DIGAMI protocol  07:14 – Retinopathy screening  08:45 – The future of care  12:25 – Teaching skills 

What do retinal scans reveal about diabetes complications? In Part 2, Vinod Patel shares insights from his clinical research on diabetic retinopathy, including key risk factors, the impact of hypertension, and the future of screening using advanced imaging tools. A must-listen for clinicians and anyone curious about the eyes-diabetes connection.  Timestamps: 00:30 – Risk factors  02:17 – Drug treatments  03:01 – Retinal ischaemia   06:12 – Retinal imaging 

Vinod Patel joins host Catherine Glass to explore how technology, early intervention, and integrated care are changing diabetes prevention. Learn about the ‘Alphabet Strategy', machine learning in postpartum prediabetes prediction, and the growing role of glucagon-like peptide-1 (GLP-1) injectables. This episode unpacks how we can identify and reduce diabetes risk before complications begin.  00:36 – Alphabet Strategy  03:04 – Vascular complications  05:10 – Machine learning  09:09 – GLP-1 agonists 

In this rapid-fire episode, Vinod Patel answers key questions about Type 2 diabetes, from early signs and screening frequency to emerging tech, common misconceptions, and lifestyle advice. Perfect for listeners short on time but eager to boost their diabetes knowledge in just 5 minutes. 

In this episode, host Jonathan Sackier is joined by Emanuele Angelucci, Director of Hematology and Cellular Therapies and Director of the Stem Cell Transplant and Cellular Therapies Program at the Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Ospedale Policlinico San Martino Hospital in Genoa, Italy.   Timestamps   00:00 – Introduction 02:14 – The future of stem cell transplantation 03:15 – What continues to drive Emanuele in his work 05:40 – Donation of haematopoietic stem cells 10:00 – Gene therapy for haemoglobinopathies 11:40 – Will stem cell transplantation remain central in treating thalassaemia and sickle cell disease? 14:14 – Emanuele's work on iron overload and toxicity 16:53 – Current landscape for haemoglobinopathies 22:11 – Key recommendations in the most recent clinical guidelines for haemoglobinopathies  25:00 – Promising developments on the horizon for patients with haemoglobinopathies  28:00 – Emanuele's key takeaways 

In this deeply personal episode, Jonathan Sackier speaks with Zoe Strickland, author of To Grief With Love, about how she navigated the loss of her son and found space for healing through creative expression and connection. They reflect on the evolving nature of grief, the importance of making space for sadness, and the small but powerful ways we can support ourselves and each other through loss. Zoe's story is one of honesty, vulnerability, and hope, inviting listeners into a compassionate conversation about grief, meaning, and remembrance.   Timestamps (00:00) – Introduction (04:14) – Journalling and the birth of Doodle Lady (10:00) – Mindfulness and slowing down (15:20) – Helping others through shared experience (17:10) – Revisiting the five stages of grief (18:10) – A more fluid view: coping, learning, and growing (22:27) – Finding meaning through creativity and community (26:35) – The role of divinity in healing (30:47) – The Grief Room Door – honouring stillness (34:47) – Why time and space matter after loss (36:32) – The value of therapy and support (39:29) – Living with anniversaries (44:00) – Understanding suicide beyond labels (46:54) – Theory of Constraints and supporting prevention (51:26) – Finding resources and safe spaces (53:54) – A gentle closing reflection

In this series, host Catherine Glass speaks with David Cosio about  the complex and often overlooked relationship between anxiety and chronic pain. They explore the neurobiological underpinnings of both conditions, how they influence each other, and what the future of integrated pain management may look like, from AI to psychedelics and beyond.  0:47 - Acceptance and Commitment Therapy  3:17 - Anxiety and Chronic Pain  5:50 - ‘Let Them' Concept  8:09 - David's Book  10:07 - Book Section Recommendations  11:20 - Lifestyle Factors  12:00 - Grief and Chronic Pain  14:06 - Delayed Reaction to Grief 

In this episode, host Catherine Glass speaks with David Cosio about  the complex and often overlooked relationship between anxiety and chronic pain. They explore the neurobiological underpinnings of both conditions, how they influence each other, and what the future of integrated pain management may look like, from AI to psychedelics and beyond. 

In this episode of Onc Now, host Jonathan Sackier is joined by Simon Lord, Associate Professor in Experimental Cancer Therapeutics, University of Oxford, UK, to discuss translating scientific breakthroughs into real-world treatments. With deep expertise in precision medicine and a passion for innovation in oncology, Lord brings a unique perspective on how the future of cancer therapy is being shaped today.      Timestamps  01:04 – Quickfire question  11:26 – Metabolic imaging  15:26 – Insulin resistance  18:04 – Patient-specific biology  20:35 – Tamoxifen risks  21:57 – Metabolic interventions  24:46 – Lifestyle changes  27:04 – Clinical trials  00:00 – Wishes for healthcare 

In this series, host Catherine Glass speaks with David Cosio about  the complex and often overlooked relationship between anxiety and chronic pain. They explore the neurobiological underpinnings of both conditions, how they influence each other, and what the future of integrated pain management may look like, from AI to psychedelics and beyond.  Timestamps: 1:07 - Background  2:10 - Day to Day  3:21 - Why Pain Management  6:06 - Conversations About Pain  7:54 - Key Neurobiological Mechanisms  9:50 - Genetics  11:02 - Brain Mechanisms  11:32 - Biomarkers 

In this series, host Catherine Glass speaks with David Cosio about  the complex and often overlooked relationship between anxiety and chronic pain. They explore the neurobiological underpinnings of both conditions, how they influence each other, and what the future of integrated pain management may look like, from AI to psychedelics and beyond. 

In the second episode of our Rare Lung Diseases podcast mini-series, host Saranya Ravindran delves into the complexities of pulmonary arterial hypertension (PAH) with Neal Chaisson, Assistant Professor of Medicine at the Cleveland Clinic. Chaisson shares insights into why PAH remains under-recognised, the nuances of detection and diagnosis, and what the latest advancements mean for patients and clinicians. The discussion covers everything from early warning signs to future directions in PAH management and research. Timestamps: 01:05 – Diagnostic workflows 03:58 – Non-invasive tools 05:37 – Right heart catheterisation values 09:05 – Vasoreactivity testing 11:10 – Genetic testing 13:08 – Innovative diagnostics

In the second episode of our Rare Lung Diseases podcast mini-series, host Saranya Ravindran delves into the complexities of pulmonary arterial hypertension (PAH) with Neal Chaisson, Assistant Professor of Medicine at the Cleveland Clinic. Chaisson shares insights into why PAH remains under-recognised, the nuances of detection and diagnosis, and what the latest advancements mean for patients and clinicians. The discussion covers everything from early warning signs to future directions in PAH management and research. Tinestamps: 00:45 – PAH management 03:05 – Hypoxia 06:42 – Decompensated PAH 10:06 – At-home treatments 12:44 – Multidisciplinary teams 14:50 – Novel therapies

In this episode of Onc Now, host Jonathan Sackier is joined by Stephen Freedland, Surgical Oncologist at Cedars-Sinai Medical Center, Los Angeles, California, USA, to discuss the intersections of biology, behaviour, and bias in prostate cancer. From diet and exercise to disparities in outcomes and promising data on enzalutamide, Freedland challenges assumptions and advocates for a more holistic, equitable approach to care.  Timestamps   01:20 – Background and clinical journey 02:39 – Cancer myths: what needs busting 03:22 – Lifestyle's role in prostate cancer 05:18 – One habit all cancer patients should adopt 06:39 – Yes or No round 10:30 – Diet, obesity, and exercise: the data 13:25 – Mediterranean diet and outcomes 15:30 – Predictive lifestyle factors 16:19 – Racial disparities and root causes 18:35 – Gender-affirming treatment and prostate cancer in trans women 23:20 – Enzalutamide: latest data and developments 25:51 – Broader therapeutic landscape 28:40 – Risk of recurrence 30:19 – Advice for young oncologists 34:00 – Three wishes for the future of prostate cancer care 

In the second episode of our Rare Lung Diseases podcast mini-series, host Saranya Ravindran delves into the complexities of pulmonary arterial hypertension (PAH) with Neal Chaisson, Assistant Professor of Medicine at the Cleveland Clinic. Chaisson shares insights into why PAH remains under-recognised, the nuances of detection and diagnosis, and what the latest advancements mean for patients and clinicians. The discussion covers everything from early warning signs to future directions in PAH management and research.  Timestamps:   Part 1:   01:00 – What is PAH  02:34 – Risk factors  04:21 – Misdiagnoses  07:13 – Pathophysiology  10:44 – World Symposium classification 

In the second episode of our Rare Lung Diseases podcast mini-series, host Saranya Ravindran delves into the complexities of pulmonary arterial hypertension (PAH) with Neal Chaisson, Assistant Professor of Medicine at the Cleveland Clinic. Chaisson shares insights into why PAH remains under-recognised, the nuances of detection and diagnosis, and what the latest advancements mean for patients and clinicians. The discussion covers everything from early warning signs to future directions in PAH management and research. 

In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care. Timestamps: 1:20 - Current barriers to timely diagnosis 4:35 - How close are we to identifying all patients with Alpha 1? 5:20 - Role of consumer genomics in alpha detection 6:20 – Targeted testing amongst COPD patients

In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care. Timestamps: 01:00 - Management of Alpha 1 03:30 - Augmentation therapy 05:50 - The discussion of neonatal screening for Alpha 1 08:00 - Evolving landscape 09:40 - Patients' challenges with Alpha 1 11:20 - Closing comments on Alpha 1

In this episode, host Jonathan Sackier is joined by Steven Okoli, Honorary Senior Clinical Lecturer at Imperial College London. From leading the UK's first adult stem cell transplant trial for sickle cell disease to driving innovation in AI-guided transfusion strategies, Okoli shares how clinical research, patient advocacy, and equity-driven care are reshaping the landscape of haemoglobinopathies in the UK and beyond.  Timestamps  00:00: Introduction  01:58: Quickfire round  09:09: Pioneering adult stem cell transplant in sickle cell  11:41: Combining AI and genetics for blood transfusion  13:58: Systemic disparities in sickle cell  20:58: Education and advocacy  23:30: Non-cancerous blood disorders  25:18: What's next in sickle cell?  27:27: Okoli's three wishes for healthcare  

In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care.

In the first episode of our Rare Lung Diseases podcast series, host Saranya Ravindran speaks with James Stoller, Chief of Education and Pulmonary Physician at Cleveland Clinic, about Alpha-1 antitrypsin deficiency, a rare genetic condition that is frequently underdiagnosed. The discussion explores the complexities of Alpha 1, including current challenges in detection, advances in diagnosis and management, and what the future may hold for improving care. Timestamps 00:56 – What is Alpha-1 antitrypsin deficiency? 01:45 – Mechanism of this genetic disorder 03:12 – What makes Alpha 1 so hard to spot? 04:30 – Genetic complexities of Alpha 1 06:00 – Risk factors  

In this episode of Onc Now, host Jonathan Sackier is joined by Jean Abraham, Professor of Precision Breast Cancer Medicine at the University of Cambridge, to delve into the future of integrated cancer medicine, the evolving role of clinical trials, and how precision oncology is redefining outcomes for patients with breast cancer across the UK.  Timestamps  00:00 – Introduction  01:28 – Quickfire round  09:50 – Cambridge institutes for precision medicine  12:53 – Predictive/prognostic tools in breast cancer  15:33 – The future of breast cancer clinical trials  18:34 – Integrating genomic data  22:31 – Addressing cost barriers  24:22 – How AI is transforming breast cancer care  28:08 – Why oncology?  30:04 – A message to non-oncologists  31:54 – Abraham's three wishes for healthcare  

In this episode, Jonathan Sackier welcomes Claudio Cerchione, haematologist and researcher at the Hematology Unit, Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST) IRCCS, Meldola, Italy. From his early interest in plasma cell disorders, Cerchione shares key insights into the evolution of multiple myeloma (MM) research, the rising role of minimal residual disease (MRD), and promising developments in monoclonal antibodies and CAR-T therapy. He also reflects on standout moments from recent European Hematology Association (EHA) Congress and American Society of Clinical Oncology (ASCO) Annual Meeting, and shares his hopes for the future of haematology.   Timestamps: 2:14: Memorable career experiences for Claudio   4:20 Biggest breakthrough in MM  5:10 Interest in plasma cell disorders  6:30 A surprising fact about multiple myeloma  7:40 Claudio's top choice for a dinner party guest  10:30 The importance of MRD in haematology  13:00 Monoclonal antibodies and CAR-T therapies  19:00 Current challenges  22:22 Claudio's key EHA and ASCO takeaways  28:30 Claudio's three magic wishes  

In this three-part series, Jonathan Sackier sits down with Professor Zoë Paskins to explore the complexities and advancements in rheumatology and bone health. From her personal journey into the field to innovations in managing osteoporosis and arthritis, Zoë offers compelling insights into the current landscape and future of musculoskeletal care.   Timestamps: 0:25 - What's new in osteoporosis management? 5:05 - Key challenges in addressing gaps in care

In this three-part series, Jonathan Sackier sits down with Professor Zoë Paskins to explore the complexities and advancements in rheumatology and bone health. From her personal journey into the field, to innovations in managing osteoporosis and arthritis, Zoë offers compelling insights into the current landscape and future of musculoskeletal care. Timestamps:     00:00 - Introduction 03:45 - Zoë's start in rheumatology and what keeps her passionate 06:27 - Shared decision-making in rheumatology 12:30 - How should we be screening for osteoporosis?

In this episode of Hema Now, host Jonathan Sackier is joined by Kevin Rouault-Pierre and Onima Chowdhury, to explore the biological mechanisms behind MDS, with a spotlight on SF3B1 mutations. From epigenetic stress to diagnostic strategies, this discussion bridges laboratory research and frontline care.  Timestamps 01:11 – Quickfire Round 07:11 – Haematology Misconceptions  10:56 – Understanding MDS 18:42 – Treating Myeloid Malignancies 23:20 – Epigenetic Mechanisms 28:30 – MDS Treatment Approaches 34:56 – Three Wishes 

Plant-Based Diets In this series, the host Catherine Glass welcomes Stacy Loeb, a renowned urologist and lifestyle medicine advocate, to explore the growing impact of environmental factors on men's health. From the risks of microplastics and the benefits of plant-based diets to the carbon cost of prostate procedures, these conversations challenge conventional clinical perspectives and offer practical, planet-conscious solutions for modern urology. 0:19 – The connection between diet and health 4:05 – Organic versus non-organic: does it matter? 4:56 – Plant-based diets and improved erectile function 7:19 – Stigma and undertreatment in men's health 9:14 – Research from the Prostate Cancer Foundation 11:57 – The growing role of lifestyle medicine 14:49 – Glucagon-like peptide-1 (GLP-1) agonists in urological health