Podcasts about idrs

This Day in Legal History: Army-McCarthy Hearings BeginOn April 22, 1954, the Army-McCarthy hearings began in Washington, D.C., marking a pivotal moment in American legal and political history. The televised proceedings, which stretched over two months, were convened to investigate conflicting accusations between Senator Joseph McCarthy and the U.S. Army. McCarthy claimed the Army was sheltering communists; the Army countered that McCarthy and his chief counsel, Roy Cohn, had improperly pressured military officials to give preferential treatment to a former McCarthy aide.These hearings drew millions of viewers and brought McCarthy's aggressive, often unsubstantiated allegations into public view. Under questioning, McCarthy's bullying tactics and disregard for evidence became increasingly apparent. The most famous moment came when Army counsel Joseph Welch rebuked McCarthy with the now-historic line, “Have you no sense of decency, sir?”—a turning point in the hearings and in public perception of McCarthy.As support for McCarthy dwindled, the hearings exposed the dangers of reckless accusations without due process, a central legal concern during the Red Scare. Later that year, the Senate formally censured McCarthy, effectively ending his political influence. The hearings stand as a cautionary tale about the abuse of investigatory powers and the erosion of civil liberties in times of national fear. They also highlight the essential role of transparency and accountability in American governance. The legacy of the Army-McCarthy hearings continues to inform debates over the balance between national security and individual rights.Alphabet's Google faces a major antitrust trial starting Monday in Washington, as the U.S. Department of Justice and 38 state attorneys general seek to break up its dominance in the search engine market. Central to the government's case is a proposal for Google to sell its Chrome browser and potentially even its Android operating system if competition isn't restored. Prosecutors argue that Google's exclusive agreements, like those paying billions to Apple and other companies to be the default search engine, have harmed rivals, including emerging AI firms like Perplexity AI and OpenAI.Google insists the DOJ's demands are extreme and warns that ending these deals could harm browser makers like Mozilla and raise smartphone costs. U.S. District Judge Amit Mehta is presiding over the trial, expected to last three weeks. Google plans to appeal any unfavorable ruling and argues that its deals help fund free, open-source technology. The case follows a separate DOJ victory last week, where a judge found Google maintained an illegal monopoly in ad tech. The trial's outcome could dramatically reshape how Americans access information online and influence future antitrust enforcement, with similar scrutiny already aimed at companies like Meta.Google faces trial in US bid to end search monopoly | ReutersThe U.S. Supreme Court declined to hear Minnesota's appeal defending its law that barred individuals under 21 from obtaining permits to carry handguns in public. This decision leaves in place a ruling from the 8th U.S. Circuit Court of Appeals that found the restriction unconstitutional under the Second Amendment. The case is one of many that have challenged age-based and other gun restrictions following the Supreme Court's 2022 Bruen decision, which established that firearm regulations must align with the nation's historical traditions to be valid.Gun rights groups, including the Minnesota Gun Owners Caucus and Firearms Policy Coalition, challenged the law, arguing it infringed on the rights of 18- to 20-year-olds. Minnesota defended the law as a modest safety measure, noting that youths already have access to guns under specific conditions, such as hunting or supervision. The 8th Circuit disagreed, saying the state failed to prove that young adults posed a sufficient threat or that the restriction had historical precedent.While more than 30 states have similar age-related laws, Minnesota's could no longer be enforced once the appeals process concluded. The case underscores how courts are interpreting and applying the Bruen test, which has reshaped the legal landscape for gun laws. Although the Supreme Court has upheld some modern firearm restrictions, it has consistently signaled that any such laws must fit within historical frameworks.US Supreme Court won't save Minnesota age restriction on carrying guns | ReutersIn my column for Bloomberg Tax this week, I talk about the risk posed by the Department of Government Efficiency's (DGE) access to taxpayer data. If the federal government wants more access to your tax data, it should have to meet a high bar—proving a clear need, protecting the information, and being transparent about how it's used. Right now, the DGE, spearheaded by Elon Musk, is pushing for expanded access to the IRS's Integrated Data Retrieval System (IDRS), which holds deeply sensitive taxpayer records. The rationale? To root out fraud and streamline federal oversight. But noble intentions aren't a substitute for safeguards—and as it stands, DGE hasn't provided any clear guardrails for how it would handle this data.We've seen how this can go wrong. In Sweden, the national tax agency is now facing a lawsuit for sharing taxpayer data with private companies, including marketers and data brokers. Sweden's commitment to constitutional transparency has been used to justify these disclosures, even as they appear to violate Europe's strict privacy laws. It's a reminder that transparency can be weaponized, and privacy treated as an inconvenience. If that sounds extreme, just imagine your tax return fueling a marketing database in the name of government openness.In the U.S., Section 6103 of the tax code makes unauthorized disclosure of taxpayer data a felony. DGE's quest to tap into the IDRS raises serious questions about whether internal access could amount to disclosure, especially if it increases the risk of leaks, misuse, or political meddling. DGE already has access to some refund-related data, but it's now seeking far more granular insight—without explaining what it will do with it, or how it will prevent abuse.What Sweden's case makes clear is that even the best intentions can lead to disastrous outcomes when privacy is not treated as sacrosanct. The U.S. should take that warning seriously. Taxpayer data is among the most sensitive information the government holds. Expanding access to it—especially by an agency as vaguely defined as DGE—should not happen without a fully transparent, purpose-limited, and accountable framework.Until then, DGE should not be granted access to the IRS's IDRS system or any individualized taxpayer information. The risks are too high, and the protections too flimsy. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.minimumcomp.com/subscribe

On this episode we come to you from IDRS 2024 in Flagstaff, AZ! For our interview we welcome Amanda Swain, Principal Bassoonist of the Houston Grand Opera Orchestra, Second Bassoonist of the Houston Ballet Orchestra, and Adjunct Professor of Bassoon at Sam Houston State University! This podcast is brought to you by Chemical City Double Reeds (www.chemicalcityreeds.com), ACDC Reeds(www.acdcreeds.com/), Barton Cane (www.bartoncane.com/), and RDG Woodwinds Inc. (rdgwoodwinds.com)! Thank you to our wonderful sponsors!

On this episode, we dish about the upcoming IDRS conference and Galit's recent trip to visit our friends at Barton Cane! For our interview, we welcome Virginia McDowell, Principal Oboe of the Louisiana Philharmonic! This episode is brought to you by Barton Cane (www.bartoncane.com/), Ugly Duckling Oboes (uglyducklingoboes.com/), Chemical City Double Reeds (www.chemicalcityreeds.com/)and Oboe Chicago (www.oboechicago.com). Thank you to our amazing sponsors!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.06.531372v1?rss=1 Authors: Gurley, N., Szymanski, R., Dowen, R. H., Butcher, T. A., Ishiyama, N., Peifer, M. Abstract: One central question for cell and developmental biologists is defining how epithelial cells can change shape and move during embryonic development without tearing tissues apart. This requires robust yet dynamic connections of cells to one another, via the cell-cell adherens junction, and of junctions to the actin and myosin cytoskeleton, which generates force. The last decade revealed that these connections involve a multivalent network of proteins, rather than a simple linear pathway. We focus on Drosophila Canoe, homolog of mammalian Afadin, as a model for defining the underlying mechanisms. Canoe and Afadin are complex, multidomain proteins that share multiple domains with defined and undefined binding partners. Both also share a long carboxy-terminal intrinsically disordered region (IDR), whose function is less well defined. IDRs are found in many proteins assembled into large multiprotein complexes. We have combined bioinformatic analysis and the use of a series of canoe mutants with early stop codons to explore the evolution and function of the IDR. Our bioinformatic analysis reveals that the IDRs of Canoe and Afadin differ dramatically in sequence and sequence properties. When we looked over shorter evolutionary time scales, we identified multiple conserved motifs. Some of these are predicted by AlphaFold to be alpha-helical, and two correspond to known protein interaction sites for alpha-catenin and F-actin. We next identified the lesions in a series of eighteen canoe mutants, which have early stop codons across the entire protein coding sequence. Analysis of their phenotypes are consistent with the idea that the IDR, including its C-terminal conserved motifs, are important for protein function. These data provide the foundation for further analysis of IDR function. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

The Story of Adam (#20) Sheth and Idrs

On this episode we debrief about IDRS 2022! For our interview we welcome Javier Rodriguez, Associate Professor of Bassoon Javier at the University of Idaho's Lionel Hampton School of Music! This podcast is brought to you by Chemical City Double Reeds (www.chemicalcityreeds.com), Reedesign(www.reedesign.io), Barton Cane (www.bartoncane.com/), and RDG Woodwinds Inc. (rdgwoodwinds.com)! Thank you to our wonderful sponsors!

In this episode we get excited about IDRS 2022 and other upcoming performances! For our interview, we welcome William McMullen, Professor of Oboe at the University of Nebraska–Lincoln! This episode is brought to you by Barton Cane (www.bartoncane.com/), Ugly Duckling Oboes (uglyducklingoboes.com/), Chemical City Double Reeds (www.chemicalcityreeds.com/)and Oboe Chicago (www.oboechicago.com). Thank you to our amazing sponsors!

International ratings agency, Fitch, has downgraded Ghana's Long-Term Foreign-Currency Issuer Default Rating (IDR) to ‘B-‘ from ‘B' with a negative outlook. the downgrade of Ghana's IDRs and Negative Outlook reflect the sovereign's loss of access to international capital markets in the second-half of 2021, following a pandemic-related [COVID-19] surge in government debt.

1) Investment in listed/unlisted companies under Foreign Direct Investment A foreign individual can make investments in Indian companies under FDI policy up to the maximum FDI allowed in the sector in which the investee company is operating. FDI means investment in capital instruments. In the case of listed companies, FDI shall be 10% or more of the post-issue paid-up equity capital of the company. 2) Investment in LLPs under Foreign Direct Investment LLPs can accept FDI only if they are operating in sectors in which 100% FDI under automatic route is allowed by the government. 3) Investment in partnership firms/sole proprietorships Investments by NRIs in partnership firms/sole proprietorships can be either on a repatriable basis or on a non-repatriable basis. Investment on a repatriation basis means an investment, the sale/ maturity proceeds of which are, net of taxes, eligible to be repatriated (sent back to their own country) out of India. Investment on a non-repatriation basis means its funds cannot be transferred back to the NRIs country of residence nor can they be converted to any foreign currency. Investment by non-residents other than NRIs can be done after taking approval of the RBI.  4) Investment under Foreign Portfolio Investment Investment under FPI can be done after getting registered with SEBI. FPI under SEBI regulations can be made in listed securities of a body corporate, mutual funds, CIS, derivatives traded on a recognized stock exchange, REITs, INVITs, category III AIFs, IDRs, debt securities permitted by RBI. 5) ADRs/GDRs ADRs/GDRs are issued by foreign banks in any foreign jurisdiction on the basis of underlying shares issued by an Indian company. Investment in ADRs/GDRs falls under the automatic route and does not require any approval. 6) Foreign Venture Capital Investment FVCI means an investment made through foreign venture capital investors registered with SEBI. They pool investment from foreign investors and invest them as per the SEBI regulations. Investment by FVCI is done in venture capital funds, venture capital undertaking, and listed companies. So, What is Instade Alogs is all about? It is an audio learning and discussion forum enriching our listeners to get all the valuable insights related to the professional world. You can connect with us on Linkedin | Twitter | Facebook | Instagram We are Listed on the Below mentioned Platforms, you may subscribe to anyone to get instant updates : Listen on Spotify  | Apple Podcasts | Google Podcasts | Castbox | Radio Public | Pocket Casts | Overcast  | Breaker  

On this episode, Jacqui and Galit debrief after their IDRS panel and set intentions for the new academic year. For our interview, we welcome Jonathan Fischer, principal oboe of the Houston Symphony! This episode is brought to you by Jennet Ingle Reeds(jennetingle.com/store), Ugly Duckling Oboes (uglyducklingoboes.com/), Chemical City Double Reeds (www.chemicalcityreeds.com/)and Oboe Chicago (www.oboechicago.com). Thank you to our amazing sponsors!

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.10.376327v1?rss=1 Authors: Frank, F., Liu, X., Ortlund, E. A. Abstract: The glucocorticoid receptor (GR) is a ligand-regulated transcription factor (TF) that controls the tissue- and gene-specific transactivation and transrepression of thousands of target genes. Distinct GR DNA binding sequences with activating or repressive activities have been identified, but how they modulate transcription in opposite ways is not known. We show that GR forms phase-separated condensates that specifically concentrate known co-regulators via their intrinsically disordered regions (IDRs) in vitro. A combination of dynamic, multivalent (between IDRs) and specific, stable interactions (between LxxLL motifs and the GR ligand binding domain) control the degree of recruitment. Importantly, GR DNA-binding directs the selective partitioning of co-regulators within GR condensates such that activating DNAs cause enhanced recruitment of co-activators. Our work shows that condensation controls GR function by modulating co-regulator recruitment and provides a mechanism for the up- and down-regulation of GR target genes controlled by distinct DNA recognition elements. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.20.347542v1?rss=1 Authors: Lichtinger, S. M., Garaizar, A., Collepardo-Guevara, R., Reinhardt, A. Abstract: Rationally and efficiently modifying the amino-acid sequence of proteins to control their ability to undergo liquid-liquid phase separation (LLPS) on demand is not only highly desirable, but can also help to elucidate which protein features are important for LLPS. Here, we propose an innovative computational method that couples a genetic algorithm to a sequence-dependent coarse-grained protein model to evolve the amino-acid sequences of phase-separating intrinsically disordered protein regions (IDRs), and purposely enhance or inhibit their capacity to phase-separate. We apply it to the phase-separating IDRs of three naturally occurring proteins, namely FUS, hnRNPA1 and LAF1, as prototypes of regions that exist in cells and undergo homotypic LLPS driven by different types of intermolecular interaction. We find that the evolution of amino-acid sequences towards enhanced LLPS is driven in these three cases, among other factors, by an increase in the average size of the amino acids. However, the direction of change in the molecular driving forces that enhance LLPS (such as hydrophobicity, aromaticity and charge) depends on the initial amino-acid sequence: the critical temperature can be enhanced by increasing the frequency of hydrophobic and aromatic residues, by changing the charge patterning, or by a combination of both. Finally, we show that the evolution of amino-acid sequences to modulate LLPS is strongly coupled to the composition of the medium (e.g. the presence or absence of RNA), which may have significant implications for our understanding of phase separation within the many-component mixtures of biological systems. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.16.300582v1?rss=1 Authors: Schweitzer-Stenner, R., Andres, B., Urbanc, B., Schwalbe, H., Milorey, B. Abstract: Intrinsically disordered proteins (IDPs) and regions (IDRs) are frequently enriched in charged amino acids. IDRs are regularly involved in important biological processes, where one or more charged residues is the driving force behind a protein-biomolecule interaction. Several lines of experimental and computational evidence suggest that polypeptides and proteins that carry high net charges have a high preference for extended conformations with average end to end distances exceeding expectations for self-avoiding random coils. Here, we show that charged arginine (R) residues in even short glycine (G) capped model peptides (GRRG and GRRRG) significantly affect the conformational propensities of each other when compared to the intrinsic propensities of a mostly unperturbed arginine in the tripeptide GRG. A conformational analysis based on experimentally determined J-coupling constants from heteronuclear NMR spectroscopy and amide I' band profiles from polarized Raman spectroscopy reveals that nearest neighbor interactions stabilize extended {beta}-strand conformations at the expense of polyproline II and turn conformations. The results from MD simulations with an CHARMM36m force field and TIP3P water reproduce our results only to a limited extent. The use of the Ramachandran distribution of the central residue of GRRRG in a calculation of end-to-end distances of polyarginines of different length yielded the expected power law behavior. The scaling coefficient of 0.66 suggests that such peptides would be more extended than predicted by a self-avoiding random walk. Our findings thus support in principle theoretical predictions of Mao et al. (Proc. Natl. Acad. Sci. USA, 107, 8183-8188, 2010). Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.15.297994v1?rss=1 Authors: Courchaine, E. M., Barentine, A. E. S., Straube, K., Bewersdorf, J., Neugebauer, K. M. Abstract: Biomolecular condensation is a widespread mechanism of cellular compartmentalization. Because the 'survival of motor neuron protein' (SMN) is required for the formation of three different membraneless organelles (MLOs), we hypothesized that at least one region of SMN employs a unifying mechanism of condensation. Unexpectedly, we show here that SMN's globular tudor domain was sufficient for dimerization-induced condensation in vivo, while its two intrinsically disordered regions (IDRs) were not. The condensate-forming property of the SMN tudor domain required binding to its ligand, dimethylarginine (DMA), and was shared by at least seven additional tudor domains in six different proteins. Remarkably, asymmetric versus symmetric DMA determined whether two distinct nuclear MLOs - gems and Cajal bodies - were separate or overlapping. These findings show that the combination of a tudor domain bound to its DMA ligand - DMA-tudor - represents a versatile yet specific interaction module that regulates MLO assembly and defines their composition. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.20.230268v1?rss=1 Authors: Brown, C. J., Verma, C. S., Lane, D. P., Lama, D. Abstract: Intrinsically disordered regions (IDRs) in proteins can regulate their activity by facilitating protein-protein interactions (PPIs) as exemplified in the recruitment of the eukaryotic translation initiation factor 4E (eIF4E) protein by the protein eIF4G. Deregulation of this PPI module is central to a broad spectrum of cancer related malignancies and its targeted inhibition through bioactive peptides is a promising strategy for therapeutic intervention. We have employed a structure-guided approach to rationally develop peptide derivatives from the intrinsically disordered eIF4G scaffold by incorporating non-natural amino acids that facilitates disorder-to-order transition. The conformational heterogeneity of these peptides and the degree of structural reorganization required to adopt the optimum mode of interaction with eIF4E underscores their differential binding affinities. The presence of a pre-structured local helical element in the ensemble of structures was instrumental in the efficient docking of the peptides on to the protein surface. These insights were exploited to further design features into the peptide to propagate bound-state conformations in solution which resulted in the generation of a potent eIF4E binder. The study illustrates the molecular basis of eIF4E recognition by a disordered epitope from eIF4G and its modulation to generate peptides that can potentially attenuate translation initiation in oncology. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.17.252478v1?rss=1 Authors: Moses, D., Yu, F., Ginell, G., Shamoon, N. M., Koenig, P. S., Holehouse, A. S., Sukenik, S. Abstract: Intrinsically disordered proteins and protein-regions (IDRs) make up roughly 30% of the human proteome and play vital roles in a wide variety of biological processes. Given a lack of persistent tertiary structure, all of the residues in an IDR are, to some extent, solvent exposed. This extensive surface area, coupled with the absence of strong intramolecular contacts, makes IDRs inherently sensitive to their chemical environment. Despite this sensitivity, our understanding of how IDR structural ensembles are influenced by changes in their chemical environment is limited. This is particularly relevant given a growing body of evidence showing that IDR function is linked to the underlying structural ensemble. We develop and use a combined experimental, computational, and analytical framework for high-throughput characterization of IDR sensitivity we call solution space scanning. Our framework reveals that IDRs show sequence-dependent sensitivity to solution chemistry, with complex behavior that can be interpreted through relatively simple polymer models. Our results imply that solution-responsive IDRs are ubiquitous and can provide an additional layer of biological regulation. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.17.254508v1?rss=1 Authors: Yang, X., Wang, B., Hoop, C. L., Williams, J. K., Baum, J. Abstract: Amyloid fibril formation of -synuclein (S) is associated with multiple neurodegenerative diseases, including Parkinson's Disease (PD). Growing evidence suggests that progression of PD is linked to cell-to-cell propagation of S fibrils, which leads to templated seeding of endogenous intrinsically disordered monomer. A molecular understanding of the seeding mechanism and driving interactions is crucial to inhibit progression of amyloid formation. Here, using relaxation-based solution NMR experiments designed to probe large complexes, we identify weak interactions of intrinsically disordered acetylated-S (Ac-S) monomers with seeding-competent Ac-S fibrils and seeding-incompetent off-pathway oligomers to elucidate amyloid promoting interactions at the atomic level. We identify a binding interface in the first 11 residues of the N-terminus that interacts with both fibrils and off-pathway oligomers, under conditions that favor fibril elongation. This common N-terminal hotspot is supported by suppression of seeded amyloid formation by oligomers, as observed through thioflavin-T fluorescence experiments, suggesting competing monomer interactions. This highlights that an amyloid-incompetent species of S itself can act as an auto-inhibitor against S fibril elongation. The similarity between the fibril and oligomer structures lies in their intrinsically disordered termini. Thus, we propose that the monomer-aggregate interactions occur between the intrinsically disordered monomer N-terminus and the intrinsically disordered regions (IDRs) of the fibril/oligomers. Taken together, we propose a novel Ac-S seeding mechanism that is driven by the recruitment of intrinsically disordered monomers by the fibril IDRs, highlighting the potential of the terminal IDRs of the fibril rather than the structured core, as new therapeutic targets against seeded amyloid formation. Copy rights belong to original authors. Visit the link for more info

The Know Your Rights Series 2 is presented by Newcastle Libraries REAL, the Hunter Community Legal Centre and Community Disability Alliance Hunter. These podcasts aim to support people with disabilities and the broader community. Australian and New South Wales law is discussed. Know your rights:Neighbourhood disputes and AVOs. Learn more about neighbourhood disputes and  where you can get help. Join in an enlightening conversation with Alexandra Craig,  Solicitor at Ability Rights Centre (ARC), Dale Robinson: Co-educator at ARC, Nadine Farell, Team Leader at Justice Advocacy Centre (JAS) and  host Duhita Lewis, Community Legal Education Co-ordinator, Hunter Community Legal Centre,  to learn more. This is a Newcastle Libraries REAL production. Disclaimer:         The information provided in this session is for information purposes only. It must not be relied on as legal advice. You should seek individual legal advice about your own particular circumstances.  Links: The Hunter Community Legal Centre (HCLC) is a not-for-profit organisation that provides free legal assistance to people who live, work or study in the Newcastle and Hunter community https://www.hunterclc.com.au/ Ability Rights Centre (ARC) is a Community Legal Centre that provides  legal and advocacy services to people with cognitive impairment throughout NSW. ARC is a service of IDRS. www.abilityrights.org.au The Justice Advocacy Service (JAS) supports young people and adults with cognitive impairment in contact with the NSW criminal justice system including as victims, witnesses and suspects/defendants to exercise their rights and fully participate in the process. JAS is a service of IDRS. www.justiceadvocacy.org.au Community Disability Alliance Hunter – CDAH- is the local Disabled People’s organisation in the Hunter. We are run for an by people with disability http://www.cdah.org.au/about See omnystudio.com/policies/listener for privacy information.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.07.02.184796v1?rss=1 Authors: Singh, A., Hulsmeier, J., Kandi, A. R., Pothapragada, S. S., Hillebrand, J., Petrauskas, A., Agrawal, K., RT, K., Thiagarajan, D., Vijayraghavan, K., Ramaswami, M., Bakthavachalu, B. Abstract: Ataxin-2 is a conserved translational control protein associated with spinocerebellar ataxia type II (SCA2) and amyotrophic lateral sclerosis (ALS) as well as an important target for ALS therapeutics under development. Despite its clinical and biological significance, Ataxin-2's activities, mechanisms and functions are not well understood. While Drosophila Ataxin-2 (Atx2) mediates mRNP condensation via a C-terminal intrinsically disordered domain (cIDR), how Ataxin-2 IDRs work with structured (Lsm, Lsm-AD, and PAM2) domains to enable positive and negative regulation of target mRNAs remains unclear. Using TRIBE (Targets of RNA-Binding Proteins Identified by Editing) technology, we identified and analysed Atx-2 target mRNAs in the Drosophila brain. We show that Atx2 preferentially interacts with AU-rich elements (AREs) in 3'UTRs and plays a broad role in stabilization of identified target mRNAs. Strikingly, Atx2 interaction with its targets is dependent on the cIDR domain required for neuronal-granule formation. In contrast, Atx2 lacking its Lsm domain not only interacts more efficiently with the target mRNA identified, but also forms larger RNP granules. Providing an extensive dataset of Atx2-interacting brain mRNAs, our results demonstrate that Atx2: (a) interacts with target mRNAs within RNP granules; (b) modulates the turnover of these target mRNAs; (c) has an additional essential role outside of mRNP granules; and (d) contains distinct protein domains that drive or oppose RNP-granule assembly. These findings increase understanding of neuronal translational control mechanisms and inform Ataxin-2-based interventions in development for SCA2 and ALS. Copy rights belong to original authors. Visit the link for more info

On this episode we share recent news and discuss our favorite IDRS conference memories. For our interview we welcome Sophie Dervaux, principal bassoon of the Vienna State Opera Orchestra and the Vienna Philharmonic. Learn more about Sophie at https://sophiedervaux.com. This podcast is brought to you by Chemical City Double Reeds (https://www.chemicalcityreeds.com), Edmund Nielsen Woodwinds (www.nielsen-woodwinds.com), Barton Cane (www.bartoncane.com), and Singin' Dog Double Reed Supplies (www.singindog.com)! Thank you to our wonderful sponsors!

On this episode we reflect on IDRS 2019 and the quest for perfection! For our interview we welcome Saxton Rose, Associate Professor of Bassoon at the University of North Carolina School of the Arts. For more information about Saxton, visit his website at https://www.saxtonrose.com This podcast is brought to you by Jende Reed Knives (www.jendeindustries.com), Edmund Nielsen Woodwinds (www.nielsen-woodwinds.com), Singin' Dog Double Reed Supplies (www.singindog.com), and Barton Cane (www.bartoncane.com/)! Thank you to our wonderful sponsors!

On this episode we discuss IDRS 2019 and ideas for creative concerts. For our interview we welcome Alecia Lawyer, Founder, Artistic Director & Principal Oboe of the River Oaks Chamber Orchestra. Learn more about Alecia and ROCO at https://roco.org! This episode is brought to you by Jende Reed Knives (www.jendeindustries.com), Jennet Ingle Reeds(jennetingle.com/about-jennet-ingle-reeds/), MKL Reeds (MKLReeds.com), and Oboe Chicago (www.oboechicago.com/). Thank you to our amazing sponsors!

Brangwynne tells us about recent work in which his lab has used light to control phase separation behavior in cells. By linking IDRs from proteins that are known to phase separate to protein domains that weakly oligomerize in response to light, his lab has generated tools that are allowing them to investigate the role of phase separation in different cell processes in many cell types.  

Alerian Co-Founder Kenny Feng sits down with Baker Botts Partner Mike Rosenwasser to discuss who deserves credit for Section 7704(d)(1)(E) of the Internal Revenue Code, how a young attorney should go about deciding on a practice area and work environment, and whether the legal profession is destined for the type of consolidation seen in accounting and management consulting.

In this episode we discuss our go-to recordings! For our interview, we welcome Andrew Parker, Assistant Professor of Oboe at the University of Texas at Austin! To learn more about Andrew, visit http://music.utexas.edu/about/people/parker-andrew! This podcast is brought to you by Singin’ Dog Double Reeds (www.singindog.com), the Southern Oboe Intensive (www.southernoboeintensive.com/), Jende Reed Knives (www.jendeindustries.com), and MKL Reeds (www.mklreeds.com). Be sure to support our sponsors at IDRS and tell them that Double Reed Dish sent you!

The BBQ looks back on some of the past annual International Double Reed Society conventions, and talks about plans for attending this summer’s convention in Tokyo, Japan. This episode brought to you by Forrests Music at forrestsmusic.com. January 21, 2015

Different ways the members of the BBQ were forced to become better players, plus more discussion of past and future IDRS conventions. Brought to you by Barton Cane, and Forrests Music. January 29, 2015

This episode of Rhetoricity, recorded at the 2015 Conference on College Composition and Communication, features an interview with Dr. Justin Hodgson. Hodgson is an assistant professor at Indiana University. He serves as general editor for the Journal for Undergraduate Multimedia Projects and is currently working on a book project entitled New Aesthetics, New Rhetorics. In spring 2015, he and Dr. Scot Barnett organized and hosted the Indiana Digital Rhetoric Symposium (IDRS). We begin by talking about what distinguishes (and doesn't distinguish) "digital rhetoric" from the "digital humanities." From there, Dr. Hodgson discusses what he hoped would happen at IDRS, which had yet to take place at the time of this interview. From there, we turn to digital rhetoric pedagogy. Specifically, Dr. Hodgson discusses Rhetoric, Play, & Games, an undergraduate course he's been teaching for a number of years. In addition to asking students to examine, play, and write about video games, the course functions as a game. We talk about both the possibilities and problems Hodgson sees in current conversations about "gamifying" education. The episode ends with some follow-up reflections on IDRS that Dr. Hodgson recorded after the symposium wrapped. He and Dr. Barnett are currently putting together a special issue of Enculturation: A Journal of Rhetoric, Writing, and Culture that will build on the symposium's proceedings. This episode features clips from Led Zeppelin's "Rock & Roll," Sharon Jones & The Dap-Kings' "Long Time, Wrong Time," and The Pharaos' "Mission Bucharest." The latter tune is licensed under Creative Commons; all other music and samples used within the provisions of fair use.