Podcasts about Morphogenesis

スイスのチーズ「テット・ド・モワンヌ」の物理メカニズムを解明　スライサーで削ると花形になる仕組みとは。　フランスのパリ大学などに所属する研究者らが発表した論文「Morphogenesis of cheese flowers through scraping」は、チーズが削られた際に生じる独特の形状を物理メカニズムで解明した研究報告だ。

Alfonso Martinez Arias is ICREA Research Professor in the department of systems bioengineering of the Universitat Pompeu Fabra in Barcelona. The recipient of numerous awards, he is co-author of the biology textbook Principles of Development, which was awarded the Royal Society of Biology book prize.Please consider signing up for TOEmail at https://www.curtjaimungal.org  Support TOE: - Patreon: https://patreon.com/curtjaimungal (early access to ad-free audio episodes!) - Crypto: https://tinyurl.com/cryptoTOE - PayPal: https://tinyurl.com/paypalTOE - TOE Merch: https://tinyurl.com/TOEmerch  Follow TOE: - *NEW* Get my 'Top 10 TOEs' PDF + Weekly Personal Updates: https://www.curtjaimungal.org - Instagram: https://www.instagram.com/theoriesofeverythingpod - TikTok: https://www.tiktok.com/@theoriesofeverything_ - Twitter: https://twitter.com/TOEwithCurt - Discord Invite: https://discord.com/invite/kBcnfNVwqs - iTunes: https://podcasts.apple.com/ca/podcast/better-left-unsaid-with-curt-jaimungal/id1521758802 - Pandora: https://pdora.co/33b9lfP - Spotify: https://open.spotify.com/show/4gL14b92xAErofYQA7bU4e - Subreddit r/TheoriesOfEverything: https://reddit.com/r/theoriesofeverything  

Dr. Shankar Srinivas is a Professor of Developmental Biology in the Department of Physiology Anatomy and Genetics based in the Institute for Developmental and Regenerative Medicine at the University of Oxford. He is also a Zeitlyn Fellow and Tutor in Medicine at Jesus College. Using mouse and human embryos as model systems, his group looks at the control of patterning and morphogenesis during the establishment of the anterior-posterior axis, gastrulation, and early cardiogenesis.  He discusses how tissues respond to forces during early development, characterizing cardiac progenitors, and his experience training internationally.

Sonali Rastogi, Founding Partner of Morphogenesis together with Founding Partner Manit have created one of the most successful architectural design companies in the world. She joins the Think.Future podcast to share her wisdom and vision for a sustainable India. Sonali has a unique perspective on sustainable architecture, and soulfully blends tradition, heritage, culture, and history, offering a bespoke and heartwarming quality to the design world.

Ellen Kamhi talks with Dr. Stephanie Mines, the founder of The TARA Approach, a nonprofit dedicated to providing sustainable health options to individuals and communities, and the founder of Climate Change and Consciousness (CCC), a global network to accelerate regenerative responses to the climate crisis. She is the author of 5 books, including We Are All in Shock: Energy Healing for Traumatic Times. Today, she speaks about the Secret of Resilience Healing Personal and Planetary Trauma through Morphogenesis. https://www.tara-approach.org/

When neuroscientist Stephanie Mines started practicing the hands-on healing Art of Compassion, she began to unravel the mystery of trauma and the secret to resilience. As a survivor of early childhood abuse, police brutality as a social justice activist, and a series of dysfunctional and abusive relationships, Mines was profoundly curious about how the human nervous system finds resilience despite the cumulative burden of chronic stress and traumatic life events. While earning her doctorate in neuropsychology, she met Mary Iino Burmeister, master of the Art of Compassion, or Jin Shin Jyutsu. Art of Compassion consists of non-invasive touch, using the fingertips, on sites of the body that are similar to acupuncture points. After the Art of Compassion helped Mines resolve her own trauma and awaken her innate resilience, she began to incorporate it into her clinical research. She discovered that the map of the body she learned from Burmeister sites correlated with the Chinese Extraordinary Meridians or Rivers of Splendor, which develop prenatally. She then began investigating our earliest neurodevelopmental processes and was able to correlate the Extraordinary Meridians with specific embryological events. She found that subtle touch on these sites in combination with trauma resolution amplifies neuroresilience, enhances creativity, restores motivation, and heals the fragmentation and disconnection associated with trauma and shock.

When neuroscientist Stephanie Mines started practicing the hands-on healing Art of Compassion, she began to unravel the mystery of trauma and the secret to resilience. As a survivor of early childhood abuse, police brutality as a social justice activist, and a series of dysfunctional and abusive relationships, Mines was profoundly curious about how the human nervous system finds resilience despite the cumulative burden of chronic stress and traumatic life events. While earning her doctorate in neuropsychology, she met Mary Iino Burmeister, master of the Art of Compassion, or Jin Shin Jyutsu. Art of Compassion consists of non-invasive touch, using the fingertips, on sites of the body that are similar to acupuncture points. After the Art of Compassion helped Mines resolve her own trauma and awaken her innate resilience, she began to incorporate it into her clinical research. She discovered that the map of the body she learned from Burmeister sites correlated with the Chinese Extraordinary Meridians or Rivers of Splendor, which develop prenatally. She then began investigating our earliest neurodevelopmental processes and was able to correlate the Extraordinary Meridians with specific embryological events. She found that subtle touch on these sites in combination with trauma resolution amplifies neuroresilience, enhances creativity, restores motivation, and heals the fragmentation and disconnection associated with trauma and shock.

What role does bioelectricity play in the formation of new organisms? How do cells connect to form a hierarchy of ever more advanced cognnition, preferences and goals? What are the implications for regenerative medicine, sense of self and consciousness? In this episode we have the extraordinary role of bio-electricity in the orchestration and elaboration of organisms to look at. I became interested in this topic in the nineties when I read a book that was controversial at the time: ‘The Body Electric', by Dr. Robert Becker who had been studying the bioelectric fields around salamanders as they regenerated limbs. I've been hoping to hear about it again ever since, but I thought the research had died out. That was until my guest Zhen Xu at the university of Michigan, spoke about the work of my guest today, in our episode #37 on her work “Histotripsy: Ultrasound for destroying cancer cells”. He is the award winning Biology professor at TUFTS Michael Levin, in the department of regenerative and developmental Biology, although he started out as a computer engineer. His specialisations are in how cells form bioleletrical networks, used for storing and recalling the pattern memories that guide morphogenesis. He then applies that to next generation Ai to help understand a top down control of pattern regulation in the new field of the bioinformatics of shape. He is also a visionary in how all this can be applied to regenerative medicine and bioengineering and his work obliges us to re-examine our approach to morphogenesis. I have been longing to find someone to talk to about the implications of this work for the biolelectric nature of collective intelligence, and how that builds up ever higher levels and layers of collective cellular agency, cognition and sense of self, culminating perhaps in collective intelligences greater than single organisms. For that answer you'll have to listen to what Michael says in the episode. What we discuss: 00:00 Intro. 06:10 Bioelectrical fields are responsible for which cells become which body parts. 07:30 The cognitive ‘glue' that binds collectives of cells to goals, agency and preferences. 09:30 Morphogenesis explained. 11:00 Self-organising cellular adaptability. 12:30 Cells also communicate using electric signals, not only neurones. 16:00 How are cognitive memories encoded in the electrical field? We don't know yet. 16:45 “Electric face” present in the field: copy it, apply it elsewhere and it grows there! 18:30 The bioelectrical pattern is instructive. 20:15 It's a simple information encoding. 20:30 Competent active cellular material. 24:30 DNA vs Bioelectricty: Analogy of Hardware vs Software with reprogrammability 28:00 Where is the location of the forms stored, memorised and encoded in the bioelectric field? 30:30 “We really have to redefine what me mean by “Where”“ 32:21 We don't know where the truths of mathematics reside. 38:10 Bioengineering: Training competent materials VS building passive materials. 40:30 Agential' material: Cells have agency and preferences. 44:30 Zenobots: cells re-program themselves in days, with no training only influenced by their environment. 50:40 Highly regenerative, cancer resistant, immortal: Plenaria asexual worms. 55:40 Gap Junctions: bioelectric gates for cells to network memories and agency 01:01:50 Cognitive hierarchy of selves within selves, with increasing levels of advanced complexity and agency, each with subjective experience. 01:08:00 Collaborative collective intelligence between organisms VS ever larger selves as one unified intelligence. 01:09:00 Testing agency at any level: Perturbative experiment over only observation. References: https://drmichaellevin.org/ https://thoughtforms.life/ Voltage movie of an embryo developing “Electric face” - Dany Adams, TUFTS Agential material Nature paper Zenobot researchWerner Lowenstein book - the discovery of Gap junctions

Michael Levin is a Distinguished Professor in the Biology Department at Tufts University, where he holds the Vannevar Bush endowed Chair, and he is also associate faculty at the Wyss Institute at Harvard University. Michael and the Levin Lab work at the intersection of biology, artificial life, bioengineering, synthetic morphology, and cognitive science. In this episode, Michael and Robinson discuss what it means—if anything determinate—to be intelligent and to be alive before turning to the various fascinating ways collective intelligence arises at all levels of the spectrum, from microbes to synthetic chimaeras, which all adaptively solve complex problems using sophisticated cognition. The Levin Lab: https://drmichaellevin.org/ OUTLINE 00:00 In This Episode… 00:55 Introduction 03:38 Michael's Research Program 05:48 What Is Intelligence? 23:26 Does It Mean Anything to be Alive? 34:50 What Is Morphogenesis? 53:20 Slime Molds, Exploding Planaria Brains, and Intercellular Communication 01:11:48 Why Is Synthetic Life Useful in the Lab? 01:27:48 Final Thoughts Robinson's Website: http://robinsonerhardt.com Robinson Erhardt researches symbolic logic and the foundations of mathematics at Stanford University. Join him in conversations with philosophers, scientists, weightlifters, artists, and everyone in-between.  --- Support this podcast: https://podcasters.spotify.com/pod/show/robinson-erhardt/support

Dr. Marc Gafni returns to the podcast, joining Paul on a deeper dive into love, eros, Cosmo-erotic humanism and the relationship between certainty and uncertainty in this Living 4D conversation.Learn more about Marc's work on his website where you can register for his free, weekly One Mountain, Many Paths program Sundays at 10 a.m. Western Time/1 p.m. Eastern Time. Take Marc's Unique Self mini-course that's also free. Check out Marc on many social media platforms, including Facebook, Instagram, Twitter, Linkedin and YouTube.TimestampsLove is a perception, not an emotion. (12:30)An interior science equation for eros. (18:54)Awareness or full throbbing aliveness. (26:38)Cosmo-erotic humanism. (37:06)Why eros matters. (40:37)Why do you care? (50:15)“You can't about love without talking about obligation.” (57:04)The field of value. (1:21:25)Moving from polarization to paradox. (1:32:09)Are belief systems damaging and dangerous? (1:43:03)The relationship between certainty and uncertainty. (1:52:09)Reclaiming the divinity of need. (1:59:42)The 8 core eros needs. (2:07:17)ResourcesThe Chemical Basis for Morphogenesis by Alan TuringPaul's Living 4D conversation with the late James CarseA Return to Eros: The Radical Experience of Being Fully Alive, Your Unique Self: The Radical Path to Personal Enlightenment and The Erotic and The Holy by Marc GafniFinite and Infinite Games: A Vision of Life as Play and Possibility and The Religious Case Against Belief by James CarseThe work of Zak Stein, Larry Page, Alan Watts and William Butler Yeats Find more resources for this episode on our website. Thanks to our awesome sponsors: CHEK Life Process Alchemy Workshop Paleovalley BiOptimizers PAUL10 Organifi CHEK20CHEK Institute/IMS1 Online L4DIMS1We may earn commissions from qualifying purchases using affiliate links.

Denis DubouleCollège de FranceÉvolution du développement et des génomesAnnée 2022-2023Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development : WelcomeColloque co-organisé par le Pr Denis Duboule et Olivier Pourquié (Boston).Intervenant(s)Jean-Léon Maître, Curie Institute, Paris

Thomas LecuitCollège de FranceDynamiques du vivantAnnée 2022-2023Colloque - Croissance et forme / Growth and Form : Active Flows in Tree-Dimensional Cell AggregatesAdrienne Roeder, Cornell University, USA

Dr Stephanie Mines' world opened up with the ancient hands-on-healing Art of Compassion, leading her back through her life of trauma and into the womb to discover the Original Dr Stephanie Mines' world opened up with the ancient hands-on-healing Art of Compassion, leading her back through her life of trauma and into the womb to discover the Original Brilliance that is all of our birthright. Needing to marry Science with Metaphysics, Dr Mines studied neuroscience and became an expert in trauma and shock. We discuss how our experiences in the womb impact our lives, how our accumulated traumas can be released with energy work and the Art of Compassion, and with the recognition of the resilience of the life force? http://www.stephaniemines.subtack.com http:/www.Tara-Approach.org that is all of our birthright. Needing to marry Science with Metaphysics, Dr Mines studied neuroscience and became an expert in trauma and shock. We discuss how our experiences in the womb impact our lives, how our accumulated traumas can be released with energy work and the Art of Compassion, and with the recognition of the resilience of the life force? http://www.stephaniemines.subtack.com http:/www.Tara-Approach.org

Dr Stephanie Mines' world opened up with the ancient hands-on-healing Art of Compassion, leading her back through her life of trauma and into the womb to discover the Original Dr Stephanie Mines' world opened up with the ancient hands-on-healing Art of Compassion, leading her back through her life of trauma and into the womb to discover the Original Brilliance that is all of our birthright. Needing to marry Science with Metaphysics, Dr Mines studied neuroscience and became an expert in trauma and shock. We discuss how our experiences in the womb impact our lives, how our accumulated traumas can be released with energy work and the Art of Compassion, and with the recognition of the resilience of the life force? http://www.stephaniemines.subtack.com http:/www.Tara-Approach.org that is all of our birthright. Needing to marry Science with Metaphysics, Dr Mines studied neuroscience and became an expert in trauma and shock. We discuss how our experiences in the womb impact our lives, how our accumulated traumas can be released with energy work and the Art of Compassion, and with the recognition of the resilience of the life force? http://www.stephaniemines.subtack.com http:/www.Tara-Approach.org

Alan Turing is well-known for his work on the Enigma code in World War II, and his theoretical work underpinning computer science. But he is less well-known for his pioneering work on one of the great challenges of biology – how do complex living organisms develop from tiny collections of cells?This lecture will discuss Turing's ground-breaking work in this area, showing how patterns like a leopard's spots or a zebra's stripes can occur in nature.A lecture by Sarah Hart recorded on 6 June 2023 at David Game College, London.The transcript and downloadable versions of the lecture are available from the Gresham College website: https://www.gresham.ac.uk/watch-now/turing-biologyGresham College has offered free public lectures for over 400 years, thanks to the generosity of our supporters. There are currently over 2,500 lectures free to access. We believe that everyone should have the opportunity to learn from some of the greatest minds. To support Gresham's mission, please consider making a donation: https://gresham.ac.uk/support/Website:  https://gresham.ac.ukTwitter:  https://twitter.com/greshamcollegeFacebook: https://facebook.com/greshamcollegeInstagram: https://instagram.com/greshamcollegeSupport the show

Michael Levin On Collective Intelligence Of Morphogenesis by Marwa ElDiwiny

Support us! https://www.patreon.com/mlst MLST Discord: https://discord.gg/aNPkGUQtc5 Twitter: https://twitter.com/MLStreetTalk In this eye-opening discussion between Tim Scarfe and Prof. Jim Hughes, a professor of gene regulation at Oxford University, they explore the intersection of creativity, genomics, and artificial intelligence. Prof. Hughes brings his expertise in genomics and insights from his interdisciplinary research group, which includes machine learning experts, mathematicians, and molecular biologists. The conversation begins with an overview of Prof. Hughes' background and the importance of creativity in scientific research. They delve into the challenges of unlocking the secrets of the human genome and how machine learning, specifically convolutional neural networks, can assist in decoding genome function. As they discuss validation and interpretability concerns in machine learning, they acknowledge the need for experimental tests and ponder the complex nature of understanding the basic code of life. They touch upon the fascinating world of morphogenesis and emergence, considering the potential crossovers into AI and their implications for self-repairing systems in medicine. Examining the ethical and regulatory aspects of genomics and AI, the duo explores the implications of having access to someone's genome, the potential to predict traits or diseases, and the role of AI in understanding complex genetic signals. They also consider the challenges of keeping up with the rapidly expanding body of scientific research and the pressures faced by researchers in academia. To wrap up the discussion, Tim and Prof. Hughes shed light on the significance of creativity and diversity in scientific research, emphasizing the need for divergent processes and diverse perspectives to foster innovation and avoid consensus-driven convergence. Filmed at https://www.creativemachine.io/Prof. Jim Hughes: https://www.rdm.ox.ac.uk/people/jim-hughesDr. Tim Scarfe: https://xrai.glass/ Table of Contents: 1. [0:00:00] Introduction and Prof. Jim Hughes' background 2. [0:02:48] Creativity and its role in science 3. [0:07:13] Challenges in understanding the human genome 4. [0:13:20] Using convolutional neural networks to decode genome function 5. [0:15:32] Validation and interpretability concerns in machine learning 6. [0:17:56] Challenges in understanding the basic code of life 7. [0:19:36] Morphogenesis, emergence, and potential crossovers into AI 8. [0:21:38] Ethics and regulation in genomics and AI 9. [0:23:30] The role of AI in understanding and managing genetic risks 10. [0:32:37] Creativity and diversity in scientific research

Legendary economic forecaster and pro-freedom advocate Martin Armstrong once again appears on the Outer Limits of Inner Truth Podcast to discuss: The neoconservative agenda and the likelihood for war with Russia, Political corruption in Ukraine and the impact on global perception of the United States, And why the 2023 Financial Crisis is colliding with important cyclical targets regarding war, which may result in a two-prong panic of unprecedented significance. Marin also shares his perspective on Alan Turing's groundbreaking work on the mathematical order behind Morphogenesis and offers an updated outlook on how the US will breakup. The Perfect Storm with Martin Armstrong About Martin Armstrong Martin Armstrong is a legendary economic forecaster, pro-freedom advocate, and a brilliant observer of history and human nature. Once a US based trillion dollar financial advisor, Martin developed a computer model based on the number pi and other cyclical theories to predict economic turning points with eerie accuracy (he predicted the October 1987 Black Monday crash to the very day and the Russian financial collapse in 1998). In the early 80s he established his financial forecasting and advising company Princeton Economics. His forecasts were in great demand worldwide. As Armstrong's recognition grew, prominent New York bankers invited him to join “The Club” to aid them in market manipulation. Martin repeatedly refused he was put in a cage for over ten years (see 2014's documentary “The Forecaster” – . Learn more about Martin here: 

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.14.532493v1?rss=1 Authors: Cheng, Y.-T., Luna-Figueroa, E., Woo, J., Chen, H.-C., Lee, Z.-F., Harmanci, A. S., Deneen, B. Abstract: Communication between neurons and glia plays an important role in establishing and maintaining higher order brain function. Astrocytes are endowed with complex morphologies which places their peripheral processes in close proximity to neuronal synapses and directly contributes to their regulation of brain circuits. Recent studies have shown that excitatory neuronal activity promotes oligodendrocyte differentiation; whether inhibitory neurotransmission regulates astrocyte morphogenesis during development is unknown. Here we show that inhibitory neuron activity is necessary and sufficient for astrocyte morphogenesis. We found that input from inhibitory neurons functions through astrocytic GABABR and that its deletion in astrocytes results in a loss of morphological complexity across a host of brain regions and disruption of circuit function. Expression of GABABR in developing astrocytes is regulated in a region-specific manner by SOX9 or NFIA and deletion of these transcription factors results in region-specific defects in astrocyte morphogenesis, which is conferred by interactions with transcription factors exhibiting region-restricted patterns of expression. Together our studies identify input from inhibitory neurons and astrocytic GABABR as universal regulators of morphogenesis, while further revealing a combinatorial code of region-specific transcriptional dependencies for astrocyte development that is intertwined with activity-dependent processes. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.06.531372v1?rss=1 Authors: Gurley, N., Szymanski, R., Dowen, R. H., Butcher, T. A., Ishiyama, N., Peifer, M. Abstract: One central question for cell and developmental biologists is defining how epithelial cells can change shape and move during embryonic development without tearing tissues apart. This requires robust yet dynamic connections of cells to one another, via the cell-cell adherens junction, and of junctions to the actin and myosin cytoskeleton, which generates force. The last decade revealed that these connections involve a multivalent network of proteins, rather than a simple linear pathway. We focus on Drosophila Canoe, homolog of mammalian Afadin, as a model for defining the underlying mechanisms. Canoe and Afadin are complex, multidomain proteins that share multiple domains with defined and undefined binding partners. Both also share a long carboxy-terminal intrinsically disordered region (IDR), whose function is less well defined. IDRs are found in many proteins assembled into large multiprotein complexes. We have combined bioinformatic analysis and the use of a series of canoe mutants with early stop codons to explore the evolution and function of the IDR. Our bioinformatic analysis reveals that the IDRs of Canoe and Afadin differ dramatically in sequence and sequence properties. When we looked over shorter evolutionary time scales, we identified multiple conserved motifs. Some of these are predicted by AlphaFold to be alpha-helical, and two correspond to known protein interaction sites for alpha-catenin and F-actin. We next identified the lesions in a series of eighteen canoe mutants, which have early stop codons across the entire protein coding sequence. Analysis of their phenotypes are consistent with the idea that the IDR, including its C-terminal conserved motifs, are important for protein function. These data provide the foundation for further analysis of IDR function. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Can a building address local and global imperatives? Can it be informed by the vernacular and yet be energy efficient? Can it be locally attuned and low carbon? What would this look like, say, in a place like India?

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.21.517374v1?rss=1 Authors: Spencer, W. J., Schneider, N. F., Skiba, N. P., Arshavsky, V. Y. Abstract: The photoreceptor outer segment is a modified cilium filled with hundreds of flattened disc membranes responsible for efficient light capture. To maintain photoreceptor health and functionality, outer segments are continuously renewed through the addition of new discs at their base. This process is driven by branched actin polymerization nucleated by the Arp2/3 complex. To induce actin polymerization, Arp2/3 requires a nucleation promoting factor. Here, we show that the nucleation promoting factor driving disc morphogenesis is the pentameric WAVE complex and identify all protein subunits of this complex. We further demonstrate that the knockout of one of them, WASF3, abolishes actin polymerization at the site of disc morphogenesis leading to formation of disorganized membrane lamellae emanating from the photoreceptor cilium instead of an outer segment. These data establish that, despite the intrinsic ability of photoreceptor ciliary membranes to form lamellar structures, WAVE-dependent actin polymerization is essential for organizing these membranes into a proper outer segment. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

YouTube link: https://youtu.be/kgMFnfB5E_A This theolocution has been released early in an ad-free audio version for TOE members at http://theoriesofeverything.org. Sponsors:  - Drink Trade: https://www.drinktrade.com/everything for 30% off - Ro Man: https://ro.co/curt for 20% off first order - Masterworks: https://www.masterworks.com/ promocode: theoriesofeverything *New* TOE Website (early access to episodes): https://theoriesofeverything.org/ Patreon: https://patreon.com/curtjaimungal Crypto: https://tinyurl.com/cryptoTOE PayPal: https://tinyurl.com/paypalTOE Twitter: https://twitter.com/TOEwithCurt Discord Invite: https://discord.com/invite/kBcnfNVwqs iTunes: https://podcasts.apple.com/ca/podcast/better-left-unsaid-with-curt-jaimungal/id1521758802 Pandora: https://pdora.co/33b9lfP Spotify: https://open.spotify.com/show/4gL14b92xAErofYQA7bU4e Subreddit r/TheoriesOfEverything: https://reddit.com/r/theoriesofeverything LINKS MENTIONED: - Michael Levin (Solo TOE podcast): https://youtu.be/Z0TNfysTazc - Michael Levin Theolocution With Chris Fields & Karl Friston: https://youtu.be/J6eJ44Jq_pw - Joscha Bach Theolocution With John Vervaeke: https://youtu.be/rK7ux_JhHM4 - Joscha Bach Theolocution With Donald Hoffman: https://youtu.be/bhSlYfVtgww - Joscha Bach (Solo TOE podcast): https://youtu.be/3MNBxfrmfmI This episode has been released early in an ad-free audio version for TOE members at http://theoriesofeverything.org/ TIMESTAMPS: 00:00:00 Introduction  00:01:55 Bach and Levin speak about each other's work 00:03:34 The cell functions as a neuron  00:07:15 Software as a control pattern 00:10:55 Disciplinary boundaries in academia 00:14:38 The perceptron is a "toy model" of the brain 00:18:44 How do you identify yourself as a researcher? 00:20:10 The benefits of podcasts vs. academia 00:30:04 Beliefs of Bach's and Levin's that have drastically changed 00:38:54 Memory moves outside the brain structure 00:45:06 Engrams and memory storage 00:47:30 The implications of transferring memory between species 00:55:25 Weissman's barrier 00:59:25 The notion of "competence" (Bach's and Levin's largest insight) 01:12:10 Virtualization for unreliable hardware 01:16:02 Defining "competence" 01:22:35 Bach's issues with goals (for and against teleology) 01:27:34 Planarian goals and explicitly encoded instructions 01:34:55 Navigation in "Morphic Space" 01:36:11 One species' birth defect can be another's benefit 01:37:42 The "Intelligence Trap" and bias 01:39:05 Application of each others' work to their own 01:52:25 Necessities of general intelligence in cells Learn more about your ad choices. Visit megaphone.fm/adchoices

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.10.29.514341v1?rss=1 Authors: Rodrigues, T., Dib, L., Brethaut, E., Matter, M. M., Matter-Sadzinski, L., Matter, J.-M. Abstract: The increase of brain neuron number in relation with brain size is currently considered to be the major evolutionary path to high cognitive power in amniotes. However, how changes in neuron density did contribute to the evolution of the information-processing capacity of the brain remains unanswered. High neuron densities are seen as the main reason why the fovea located at the optical center of the retina is responsible for sharp vision in birds and primates. The emergence of foveal vision is considered as a breakthrough innovation in visual system evolution. We found that neuron densities in the largest visual center of the midbrain, i.e., the optic tectum, are two to four times higher in modern birds with one or two foveae compared to birds deprived of this specialty. Interspecies comparisons enabled us to identify elements of a hitherto unknown developmental process set up by foveate birds for increasing neuron density in the upper layers of their optic tectum. The progenitor cells that generate these neurons proliferate in a ventricular zone that can expand only radially. In this particular context, the number of cells in ontogenetic columns increases, thereby setting the conditions for higher cell densities in the upper layers once neurons did migrate. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Show Notes Radioactive implant wipes tumors in unprecedented pre-clinical success | New Atlas (00:52) Pancreatic cancer is notoriously difficult to diagnose and treat, with tumor cells of this type highly evasive and loaded with mutations that make them resistant to many drugs.  3.2 percent of all cancers, yet is the third leading cause of cancer-related death Engineers at Duke University have developed a novel delivery system for cancer treatment and demonstrated its potential against one of the disease's most troublesome forms A radioactive implant completely eliminated tumors in the majority of the rodents The team wanted to figure out a way to implant into the tumor without causing damage to the surrounding tissue. Created one from more biocompatible materials (instead of titanium)  that wouldn't post the same risks to the human body. Synthetic chains of amino acids known as elastin-like polypeptides (ELPs), which form a stable gel-like material in the warmer environment of the body. This substance was injected into tumors in various mouse models of pancreatic cancer along with a radioactive element called iodine-131. ELP entombs the iodine-131 and prevents it from leaking into the body. Allows it to emit beta radiation that penetrates into the surrounding tumor. Once the radiation is spent, the ELP biogel safely degrades into harmless amino acids. The treatment was tested in combination with a common chemotherapy drug called paclitaxel. Across all the models tested, the scientists report a 100% response rate to the treatment.  In three quarters of the models, the dual treatment completely eliminated the tumors 80% of the time. The scientists deployed the novel treatment against pancreatic cancer because they wanted to explore its potential against one of the trickiest forms of the disease, but believe these results bode well for its wider application. Study author Jeff Schaal, explains the significance of their finding: “We did a deep dive through over 1,100 treatments across preclinical models and never found results where the tumors shrank away and disappeared like ours did … When the rest of the literature is saying that what we're seeing doesn't happen, that's when we knew we had something extremely interesting." In a first, scientists grow fully mature hair follicles in cultures | Interesting Engineering (07:12) According to a press release, researchers from Japan generated hair follicles in cultures while working on the processes of hair follicle growth and hair pigmentation.  Could contribute to the development of different applications such as hair loss treatment, animal testing and drug screenings. Scientists have been trying to understand the essential mechanisms of hair follicle development through animal models for a long while. Hair follicle morphogenesis wasn't something that could be reproduced in a culture dish until now. Morphogenesis is the process when the outer layer of skin and the connective tissue interacts while the embryo develops. Researchers built hair follicle organoids by controlling the structure generated from the two types of embryonic cells tapping into a low concentration of extracellular matrices. Extracellular matrix is a network that supplies structure for cells and tissue in the body. These matrices change the spacing between the two types of embryonic cells from a dumbbell-shape to core-shell configuration.  Fully mature hair follicles with approximately 3 millimeter (mm)-long hair shafts were produced by the hair follicle organoids on the 23rd day of being cultured. Researchers included a melanocyte-stimulating drug that helps produce hair color pigmentation in the culture medium.  The findings could help understand how physiological and pathological processes develop in relation to other organ systems as well.  Junji Fukuda, a professor with the faculty of engineering at Yokohama National University, speaks on next steps: “Our next step is to use cells from human origin, and apply for drug development and regenerative medicine.” Team uses live plant cells in 3D printing | Futurity (11:35) Researchers have developed a reproducible way of studying cellular communication among varied types of plant cells by “bioprinting” those cells with a 3D printer. Communication is key to understanding more about plant cell functions. Could ultimately lead to creating better crop varieties and optimal growing environments. They bioprinted cells from the model plant Arabidopsis thaliana and from soybeans to study not just whether plant cells would live after being bioprinted but also how they acquire and change their identity and function.  Lisa Van den Broeck, first author of a paper, describes the work: “A plant root has a lot of different cell types with specialized functions … There are also different sets of genes being expressed; some are cell-specific. We wanted to know what happens after you bioprint live cells and place them into an environment that you design. Are they alive and doing what they should be doing?” Live plant cells without cell walls, or protoplasts, were bioprinted along with nutrients, growth hormones, and a thickening agent called agarose. Agarose helps provide cells strength and scaffolding “When you print the bioink, you need it to be liquid, but when it comes out, it needs to be solid. Mimicking the natural environment helps keep cellular signals and cues occurring as they would in soil,” explained  Professor Ross Sozzani, co-corresponding author of the paper. The research showed that more than half of the 3D bioprinted cells were viable and divided over time to form microcalli, or small colonies of cells. Also bioprinted individual cells to test whether they could regenerate, or divide and multiply, which showed that Arabidopsis root and shoot cells needed different combinations of nutrients and scaffolding for optimal viability. More than 40% of individual soybean embryonic cells remained viable two weeks after bioprinting and also divided over time to form microcalli. End off with Professor Sozzani: “All told, this study shows the powerful potential of using 3D bioprinting to identify the optimal compounds needed to support plant cell viability and communication in a controlled environment,”  IKEA Is Using Driverless Trucks to Move Its Furniture in Texas | SIngularity Hub (18:49) Thanks to its mild climate, expansive highway network, and lax regulations, Texas has become the country's proving ground for driverless trucks. traveling the state's highways partially driver-free for a couple of years already autonomous mode on highways, but safety drivers take over to navigate city streets This week Kodiak Robotics announced a partnership to transport IKEA products using a heavy-duty self-driving truck. The route runs from an IKEA distribution center in Baytown, east of Houstin, to a store in Frisco, 290 miles away just north of Dallas. Kodiak has been around since 2018, and is focused on building a technology stack specifically for long-haul trucks.  Use a modular hardware approach that includes easy-to-install “mirror pods” with lidar and cameras. Seems like this company is on the rise with self driving trucks partnerships in place with CEVA Logistics and U.S. Express In August announced an agreement with Pilot Companies to develop services for self-driving trucks at Pilot and Flying J travel centers.  Kodiak's founder and CEO Don Burnette hopes the IKEA pilot will lead to a long-term relationship between the two companies, and an expansion of delivery routes for the furniture store.  Burnette told Forbes: “Up until now we've primarily been working with other carriers who work on behalf of shippers as their customers, and this is the first time we're working with a shipper directly … It was a really good opportunity to build that relationship and understand their operational needs.” New VR app lets you step inside your smartphone videos | Freethink (24:40) Startup Wist Labs is developing a VR app that converts your smartphone clips into 3D videos — giving you a chance to walk inside your memories using a VR headset. To create a memory with Wist, a user opens the app and records a video.  The app collects the information it needs to make the 2D clip look three-dimensional. Co-founder Andrew McHugh explained to Freethink: “During capture, we save color, depth, device pose, audio, and scene information … Depth is captured using the LiDAR sensors on the Pro model iPhones and iPads.” Once the app processes the video, the user can play it back using mobile AR or a VR headset. Video example of how it works  The next steps for Wist Labs are to close pre-seed funding, launch a beta, and then roll out features to fill in those gaps and improve the app.  McHugh plans to continue using it to capture and share memories of his first child McHugh explaining how the experience has been using it: “I loaded [an ultrasound video] into our VR app, shared it with my mom who lives halfway across the country, and we were able to both walk around that moment together … It's better than a video because it feels like you're actually there.”

Morphogenesis has an immunotherapy treatment that has worked in five out of five clinical trials on skin cancer and it's nasty cousin, Merkel Cell cancer. The company's CEO, Dr. James Bianco, says that the treatment may work against any cancer. But he doesn't want anyone calling it The Cancer Vaccine. Cal gets some insight into the potential breakthrough, and the leaps we're making in the fight against cancer. If you know someone who's been touched by cancer, check this episode out. That means everybody.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.15.508188v1?rss=1 Authors: Chen, J., Stork, T., Kang, Y., Sheehan, A., Paton, C., Monk, K., Freeman, M. Abstract: Astrocytes play crucial roles in regulating neural circuit function by forming a dense network of synapse-associated membrane specializations. Intimate astrocyte-synapse contact is thought to be crucial for astrocyte function, yet signaling pathways regulating astrocyte morphogenesis remain poorly defined. Here we show the Drosophila lipid-binding G protein-coupled receptor (GPCR) Tre1, likely acting through Rac1, is required for astrocytes to elaborate their complex morphologies. The lipid phosphate phosphatases Wunen/Wunen2, which process phospholipid ligands for Tre1, also regulate astrocyte growth, and act upstream of Tre1 as Wunen/Wunen2-mediated astrocyte overgrowth is suppressed by Tre1 loss. Loss of s1pr1, the functional analog of Tre1 in zebrafish, also leads to disruption of astrocyte morphogenesis. Live-imaging and pharmacology demonstrate that S1pr1 balances proper astrocyte process extension/retraction dynamics during morphogenesis, and that S1pr1 signaling is required throughout astrocyte development. Our work identifies lipid-binding GPCRs like Tre1 and S1pr1 as potent evolutionarily conserved regulators of astrocyte morphological complexity. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.15.508086v1?rss=1 Authors: Parichha, A., Datta, D., Suresh, V., Chatterjee, M., Holtzman, M. J., Tole, S. Abstract: The dentate gyrus, a gateway for input to the hippocampal formation, arises from progenitors in the medial telencephalic neuroepithelium adjacent to the cortical hem. Dentate progenitors navigate a complex migratory path guided by two cell populations that arise from the hem, the fimbrial glia, and Cajal-Retzius (CR) cells. Since the hem expresses multiple Wnt genes, we examined whether {beta}-CATENIN, which mediates canonical Wnt signaling and also participates in cell adhesion, is necessary for the development of hem-derived lineages. We report that the fimbrial glial scaffold is disorganized and CR cells are mispositioned upon hem-specific disruption of {beta}-CATENIN. Consequently, the dentate migratory stream is severely affected, and the dentate gyrus fails to form. Using selective Cre drivers, we further determined that {beta}-CATENIN function is required in the fimbrial glial scaffold, but not in the CR cells, for guiding the dentate migration. Our findings highlight a primary requirement for {beta}-CATENIN for the organization of the fimbrial scaffold and a secondary role for this factor in dentate gyrus morphogenesis. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

We conclude season one of Underrated ML by having Stephen Merity on as our guest. Stephen has worked at various institutions such as MetaMind and Salesforce ohana, Google Sydney, Freelancer.com, the Schwa Lab at the University of Sydney, the team at Grok Learning, the non-profit Common Crawl, and IACS @ Harvard. He also holds a Bachelor of Information Technology from the University of Sydney and a Master of Science in Computational Science and Engineering from Harvard University.In this weeks episode we talk about the current influences of hardware in the field of Deep Learning research, baseline models, strongly typed RNNs and Alan Turings paper on the chemical basis of morphogenesis.Underrated ML Twitter: https://twitter.com/underrated_mlStephen Merity Twitter: https://twitter.com/SmerityPlease let us know who you thought presented the most underrated paper in the form below: https://forms.gle/97MgHvTkXgdB41TC8Links to the papers:“The Chemical Basis of Morphogenesis” - https://www.dna.caltech.edu/courses/cs191/paperscs191/turing.pdf"Strongly-Typed Recurrent Neural Networks” - https://arxiv.org/abs/1602.02218"Quasi-Recurrent Neural Networks" - https://arxiv.org/abs/1611.01576"An Analysis of Neural Language Modelling at Multiple Scales" - https://arxiv.org/abs/1803.08240Additional Links:Aleatory architecture / hysteresis: Why Birds Are The World's Best EngineersNear decomposability: Near decomposability and the speed of evolution / The Architecture of ComplexityGoogle's All Our N-gram are Belong to You from 2006

SAMPLER & SANS REPROCHES(Radio Transmission)Playlist N∞ 1250... - Lundi 23 Mai 2022 - Horaire : 20:00 >> 22:00EBM - SYNTHWAVE - INDUSTRIAL & RELATED MUSICGALAXIE RADIO 95.3FM www.galaxieradio.fr-----------------------------------------> [ S&SR Selection de la semaine... PARADOX OBSCUR "Morphogenesis" ] < Artiste - Titre - Version - Format - Production - Label > PARADOX OBSCUR "Krankes Herz" DIG LP: Morphogenesis (Metropolis Records) DARK MINIMAL PROJECT "Next Life (People Theatre Remix)" DIG LP: Cold Black Room (Autoproduction) JEAN-MICHEL JARRE "Here For You (feat. GARY NUMAN)" CD: Electronica 2 - The Heart Of Noise (Aero Productions / Sony Music) ETHAN FAWKES & DREADFOOL "Some Fall (Original Mix)" DIG EP: Some Fall (Nu Body Records) CONTAINER 90 "Eurovision Song Protest" DIG EP: Eurovision Song Protest (Sham Recordings) AKUSTIKKOPPLER "Mittenmang" LP: Alles Muss Raus (Block 4) METAL DISCO feat. INCIRRINA "Tension" DIG EP: In Motion (Werkstatt Recordings) 0=3 "Black Tears" DIG EP: Black Tears (Ukonx Recordings) SUICIDE COMMANDO "Bang bang bang (C-Lekktor Remix)" DIG EP: Bang Bang Bang (Out Of Line Music) LIGHTS OF EUPHORIA "Access Denied" DIG SINGLE: Access Denied (Infacted Recordings) INSEKT "Another Bacteria" CD: Stress (KK Records) PARADOX OBSCUR "Evo-Devo" DIG LP: Morphogenesis (Metropolis Records) NOGA EREZ "Toy" CD: Off The Radar (City Slang) VOX LOW "Sibylline" VINYL SPLIT 7": Treasure Hunting Vol. 3 (Astro Lab Recordings) BRYAN'S MAGIC TEARS "Orion's Gate Arrival" CD: Vacuum Sealed (Born Bad Records) W.H. LUNG "Want" DIG LP: Incidental Music (Melodic) JUNKSISTA "Oxytocyn" DIG EP: Oxytocyn High (COP International) STRUMA "Dead Religion (feat.Suzi)" DIG EP: The Industrial Prayer (Autoproduction) TREPANERINGSRITUALEN "Serpent Seed (Ancient Methods Remix)" DIG EP: Kainskult Remixed (aufnahme+wiedergabe) ALIEN SKIN "This Happy Life" DIG LP: Put Your Lips On My Lips (ScentAir Records) DISTORTION SIX "Lost Vision" DIG EP: Rive (Ant-Zen) LANDSCAPE BODY MACHINE "No Cable (25TH ANNIVERSARY REMASTER)" DIG SINGLE: No Cable 2022 Remix (Autoproduction) PROMO THANKS TO : PARADOX OBSCUR (Toxic Razor), RED SAND PR (Gary Levermore), DARK MINIMAL PROJECT (Guillaume Van De Rosieren), NU BODY RECORDS (Ethan Fawkes), CONTAINER 90 (Ronny Larsson), AKUSTIKKOPPLER (Malte Steiner), WERKSTATT RECORDINGS (Toxic Razor), UKONX RECORDINGS (Stéphane), OUT OF LINE MUSIC (Iris), INFACTED RECORDINGS (Torben Schmidt), Daniéle Ludwig (L'AERONEF), COP INTERNATIONAL (Christian), STRUMA (Henrik Fink Nilsson), SCENTAIR RECORDS (Vladimir), ANT-ZEN (Stefan Alt), LANDSCAPE BODY MACHINE (Craig Joseph Huxtable) ...

WATCH: https://youtu.be/v6gp-ORTBlU Michael Levin is a Distinguished Professor in the Biology department at Tufts University. He holds the Vannevar Bush endowed Chair and serves as director of the Allen Discovery Center at Tufts and the Tufts Center for Regenerative and Developmental Biology. He attended Tufts University, interested in artificial intelligence and unconventional computation. To explore the algorithms by which the biological world implemented complex adaptive behavior, he got dual B.S. degrees, in CS and in Biology and then received a PhD from Harvard University. He did post-doctoral training at Harvard, where he began to uncover a new bioelectric language by which cells coordinate their activity during embryogenesis. EPISODE LINKS: - Mike's Website: https://wyss.harvard.edu/team/associate-faculty/michael-levin-ph-d/ - Mike's Twitter: https://twitter.com/drmichaellevin - Mike's Publications: https://scholar.google.com/citations?user=luouyakAAAAJ&hl=en - Mike's Lab: https://ase.tufts.edu/biology/labs/levin/ - TED: https://youtu.be/XheAMrS8Q1c CONNECT: - Website: https://tevinnaidu.com - Instagram: https://instagram.com/drtevinnaidu - Facebook: https://facebook.com/drtevinnaidu - Twitter: https://twitter.com/drtevinnaidu - LinkedIn: https://linkedin.com/in/drtevinnaidu TIMESTAMPS: (0:00) - Introduction (0:37) - How Mike's work changed biology (2:59) - Electrical signals as information carriers (5:16) - Defining intelligence (12:30) - Evolution of AI (17:26) - "Artificial" vs "natural" intelligence (20:19) - Developmental psychology & AI (21:37) - Animals, cyborgs & hybrids of intelligence (26:49) - Morphogenetics, embryogenesis, cellular intelligence & basal cognition (33:05) - Benefits of bioelectric communication (42:04) - Histological communication differences (46:04) - DNA as hardware & electrical signals as software (57:09) - Practical implications (1:03:41) - Xenobots (proto-animals) (1:10:22) - Regenerative medicine (1:15:11) - Conclusion Website · YouTube

WATCH: https://youtu.be/v6gp-ORTBlU Michael Levin is a Distinguished Professor in the Biology department at Tufts University. He holds the Vannevar Bush endowed Chair and serves as director of the Allen Discovery Center at Tufts and the Tufts Center for Regenerative and Developmental Biology. He attended Tufts University, interested in artificial intelligence and unconventional computation. To explore the algorithms by which the biological world implemented complex adaptive behavior, he got dual B.S. degrees, in CS and in Biology and then received a PhD from Harvard University. He did post-doctoral training at Harvard, where he began to uncover a new bioelectric language by which cells coordinate their activity during embryogenesis. EPISODE LINKS: - Mike's Website: https://wyss.harvard.edu/team/associate-faculty/michael-levin-ph-d/ - Mike's Twitter: https://twitter.com/drmichaellevin - Mike's Publications: https://scholar.google.com/citations?user=luouyakAAAAJ&hl=en - Mike's Lab: https://ase.tufts.edu/biology/labs/levin/ - TED: https://youtu.be/XheAMrS8Q1c CONNECT: - Website: https://tevinnaidu.com - Instagram: https://instagram.com/drtevinnaidu - Facebook: https://facebook.com/drtevinnaidu - Twitter: https://twitter.com/drtevinnaidu - LinkedIn: https://linkedin.com/in/drtevinnaidu TIMESTAMPS: (0:00) - Introduction (0:37) - How Mike's work changed biology (2:59) - Electrical signals as information carriers (5:16) - Defining intelligence (12:30) - Evolution of AI (17:26) - "Artificial" vs "natural" intelligence (20:19) - Developmental psychology & AI (21:37) - Animals, cyborgs & hybrids of intelligence (26:49) - Morphogenetics, embryogenesis, cellular intelligence & basal cognition (33:05) - Benefits of bioelectric communication (42:04) - Histological communication differences (46:04) - DNA as hardware & electrical signals as software (57:09) - Practical implications (1:03:41) - Xenobots (proto-animals) (1:10:22) - Regenerative medicine (1:15:11) - Conclusion Website · YouTube · YouTube

For more than two decades, Michael Allen Z Prime has pioneered the art of making music in collaboration with plants and fungi. His albums: L-Fields, One Hour As Peyote, Borneo, and The Ascent Of Sap were the first to be made in collaboration with the bioelectrical fields of plants and fungi. In his work, the fluctuations in pitch and rhythm that you hear directly follow the fluctuations of the bioelectrical fields of the organisms he is working with. Michael has presented his plant and fungal sound installations at venues around the world, including The Mendel Museum (Brno), the NTT InterCommunication Center (Tokyo), the Halles de Schaarbeek (Brussels), the Arnolfini Gallery (Bristol), the Centre for Experimental and Improvised Music (Madrid), and the old Franciscan Abbey on Sherkin Island (Ireland). His recordings of fungi have also been featured on the BBC. Michael is also a qualified ecologist, and his work in that field led him to establish the Comillane Gardens botanical gardens and nature reserve on Cape Clear Island, 10 miles south of the Irish mainland.    TOPICS COVERED:   Early Explorations of  Electroacoustic Music & Mycology  Translating the Bio-Electrical Activity of Organisms into Sound  Different Approaches to Translate Biodata from Organisms  Audio Translation of Electrical Resistance vs Bioelectrical Action PotentialsWhat Does Sound Coming from Mushrooms Tell Us?  Acoustic Differences Between Day and Nights Cycles of Fungi  Does Translating Bioelectrical Activity Also Us to Communicate with Other Organisms?  Bioactivity Translation Equipment  Michael's Mushroom Sound Exhibitions  Different Sounds of Mushrooms Indoors vs Outdoors  Differences in Sounds Between Mushroom Species  Understanding Bioactivity as Future of Understanding Fungal Networks  Demonstration Transcribing Bioelectrical Action Potentials of Mushrooms into Sound   Upcoming Projects and Collaborations  EPISODE RESOURCES:      Michael Prime Bandcamp: https://michaelallenzprime.bandcamp.com/music  Michael Prime Youtube: https://www.youtube.com/channel/UCSX2bfcI0BR-phhw1DGH7JA  Tony Bassett (only reference we could find): http://www.fsr.org.uk/spi/spibass1.htm  Merlin Sheldrake: https://www.merlinsheldrake.com/  Peziza repanda (fungus): https://www.mushroomexpert.com/peziza_repanda.html  Laricifomes officinalis (AKA Agarikon mushroom): https://en.wikipedia.org/wiki/Laricifomes_officinalis  Macrolepiota procera (AKA Parasol mushroom): https://en.wikipedia.org/wiki/Macrolepiota_procera  

Reading from TMBWOHKIP by Charles Eisenstein. Brief bonus discussion related and unrelated to the text included! Thanks for Listening!

Randolph Ashton, PhD discusses novel tissue engineering methodologies to derive brain and spinal cord tissues from human pluripotent stem cells, which can be used to create groundbreaking regenerative therapies and models of neurological disorders. Series: "Stem Cell Channel" [Science] [Show ID: 37014]

Randolph Ashton, PhD discusses novel tissue engineering methodologies to derive brain and spinal cord tissues from human pluripotent stem cells, which can be used to create groundbreaking regenerative therapies and models of neurological disorders. Series: "Stem Cell Channel" [Science] [Show ID: 37014]

Randolph Ashton, PhD discusses novel tissue engineering methodologies to derive brain and spinal cord tissues from human pluripotent stem cells, which can be used to create groundbreaking regenerative therapies and models of neurological disorders. Series: "Stem Cell Channel" [Science] [Show ID: 37014]

Randolph Ashton, PhD discusses novel tissue engineering methodologies to derive brain and spinal cord tissues from human pluripotent stem cells, which can be used to create groundbreaking regenerative therapies and models of neurological disorders. Series: "Stem Cell Channel" [Science] [Show ID: 37014]

Randolph Ashton, PhD discusses novel tissue engineering methodologies to derive brain and spinal cord tissues from human pluripotent stem cells, which can be used to create groundbreaking regenerative therapies and models of neurological disorders. Series: "Stem Cell Channel" [Science] [Show ID: 37014]

Randolph Ashton, PhD discusses novel tissue engineering methodologies to derive brain and spinal cord tissues from human pluripotent stem cells, which can be used to create groundbreaking regenerative therapies and models of neurological disorders. Series: "Stem Cell Channel" [Science] [Show ID: 37014]

Randolph Ashton, PhD discusses novel tissue engineering methodologies to derive brain and spinal cord tissues from human pluripotent stem cells, which can be used to create groundbreaking regenerative therapies and models of neurological disorders. Series: "Stem Cell Channel" [Science] [Show ID: 37014]

Randolph Ashton, PhD discusses novel tissue engineering methodologies to derive brain and spinal cord tissues from human pluripotent stem cells, which can be used to create groundbreaking regenerative therapies and models of neurological disorders. Series: "Stem Cell Channel" [Science] [Show ID: 37014]

OUTER DIMENSION PREMIERE 135 Track Title: @v4w-enko - O-Type Morphology Album Title: Proc. Morphogenesis Label: @g89records Catalogue Number: G89R011 Format: CD & Digital Release Date: Exclusive (via Patreon)January 29th, 2021 & Other platforms January 22th, 2021 Recorded and mixed by Evgeniy Vaschenko (Kyiv, Ukraine) Mastered by Evgeniy Vaschenko (Kyiv, Ukraine) Cover artwork by Evgeniy Vaschenko (Kyiv, Ukraine) Released by G89 Records (Santiago, Chile) About the release: All tracks were recorded in real-time as a basic factor. Once the tool to create the sound was developed it was possible to record internal energy with its possibilities then. Morphogenesis of previous steps of experience with the moment of now. Morphogenesis of the moment of now with external tools and the internal world. Morphogenesis of real-time processes and the current biosphere makes output in sound. “Proc. Morphogenesis” means “Procedural Morphogenesis” as well “Morphogenesis Process” The process of morphogenesis here is the experience translated into the sound with an abstract digital virtual tool - the virtual sound instrument developed by V4W.ENKO. Follow V4w-enko here: www.soundcloud.com/v4w-enko www.v4wenko.bandcamp.com www.facebook.com/V4W.ENKO www.instagram.com/v4w.enko Follow G89 Records here: www.g89records.com www.patreon.com/g89records www.g89records.bandcamp.com www.soundcloud.com/g89records OUTER DIMENSION www.soundcloud.com/outerdimension www.instagram.com/outerdimension www.facebook.com/OUTERDIMENSION www.formaviva.com/outer-dimension Premiere Requests, Infos & Promos outerdimension.au@gmail.com

Biologist and author Rupert Sheldrake is best known for his hypothesis of morphic fields and morphic resonance that leads to a vision of a living developing universe with its own inherent memory. Over the course of fifteen years of research on plant development he came to the conclusion that for understanding the development of plants, their morphogenesis, genes and gene products were not enough. Morphogenesis also depends on organizing fields. How does a massive oak grow out of an acorn? The same arguments apply to the development of animals. Since the 1920s many developmental biologists have proposed that biological organization depends on fields, variously called biological fields, developmental fields, positional fields, or morphogenetic fields.     Many organisms live as free cells, including many yeasts, bacteria and amoebas. Some form complex mineral skeletons, as in diatoms and radiolarians. Just making the right proteins at the right times cannot explain the complex skeletons of such structures without many other forces coming into play, including the organizing activity of cell membranes and microtubules.     Most developmental biologists accept the need for a holistic or integrative conception of living organization, otherwise biology will go on floundering, even drowning in oceans of data, as yet more genomes are sequenced, genes are cloned, and proteins are characterized. Hear it here - https://bit.ly/centerpallamary Learn more from the author at https://bit.ly/mattpallamary Visit Mystic Ink Publishing at https://bit.ly/mysticinkpublishing For narration information visit Russell Newton at https://bit.ly/VoW-home For production information visit Newton Media Group LLC at https://bit.ly/newtonmg Christian Holy Communion,Passover,Rupert Sheldrake,Russell Newton,NewtonMG,Matthew Pallamary,The Center of the Universe,Mystic Ink Publishing,Morphic Resonance,Morphic Fields, #ChristianHolyCommunion #Passover #RupertSheldrake #RussellNewton #NewtonMG #MatthewPallamary #TheCenteroftheUniverse #MysticInkPublishing #MorphicResonance #MorphicFields

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.09.333203v1?rss=1 Authors: Weissenbruch, K., Grewe, J., Stricker, K., Baulesch, L., Schwarz, U. S., Bastmeyer, M. Abstract: Nonmuscle myosin II (NM II) is an integral part of essential cellular processes, including adhesion and migration. Mammalian cells express up to three isoforms termed NM IIA, B, and C. We used U2OS cells to create CRISPR/Cas9-based knockouts of all three isoforms and analyzed the phenotypes on homogeneous and micropatterned substrates. We find that NM IIA is essential to build up cellular tension during initial stages of force generation, while NM IIB is necessary to elastically stabilize NM IIA-generated tension. The knockout of NM IIC has no detectable effects. A scale-bridging mathematical model explains our observations by relating actin fiber stability to the molecular rates of the myosin crossbridge cycle. We also find that NM IIA initiates and guides co-assembly of NM IIB into heterotypic minifilaments. We finally use mathematical modeling to explain the different exchange dynamics of NM IIA and B in minifilaments, as measured in FRAP experiments. Copy rights belong to original authors. Visit the link for more info

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.03.233593v1?rss=1 Authors: Morcom, L., Gobius, I., Marsh, A. P. L., Suarez, R., Bridges, C., Ye, Y., Fenlon, L., Zagar, Y., Douglas, A. M., Donahoo, A.-L., Fothergill, T., Shaikh, S., Kozulin, P., Edwards, T. J., Cooper, H. M., ,, Sherr, E. H., Chedotal, A., Leventer, R., Lockhart, P., Richards, L. J. Abstract: The forebrain hemispheres are predominantly separated during embryogenesis by the interhemispheric fissure (IHF). Radial astroglia remodel the IHF to form a continuous substrate between the hemispheres for midline crossing of the corpus callosum (CC) and hippocampal commissure (HC). DCC and NTN1 are molecules that have an evolutionarily conserved function in commissural axon guidance. The CC and HC are absent in Dcc and Ntn1 knockout mice, while other commissures are only partially affected, suggesting an additional aetiology in forebrain commissure formation. Here, we find that these molecules play a critical role in regulating astroglial development and IHF remodelling during CC and HC formation. Human subjects with DCC mutations display disrupted IHF remodelling associated with CC and HC malformations. Thus, axon guidance molecules such as DCC and NTN1 first regulate the formation of a midline substrate for dorsal commissures prior to their role in regulating axonal growth and guidance across it. Copy rights belong to original authors. Visit the link for more info

Patricia Lawman, PhD, co-founder and CEO of Morphogenesis, Inc. since 2003, received her graduate education in molecular biology and immunology from the College of Medicine at the University of Florida where she also served as a Postdoctoral Fellow in Pediatric Hematology and Oncology. Prior to founding Morphogenesis, Dr. Lawman was Division Director of Cancer Molecular Biology at the Walt Disney Memorial Cancer Institute. She has held adjunct faculty positions at the University of Central Florida and the University of South Florida and has served on numerous committees at local/state/federal levels. Dr. Lawman holds over 30 patents and as many publications and has received multiple business and scientific honors. Morphogenesis is an emerging clinical stage cell and gene therapy company. The company is testing its off-the-shelf, personalized cancer immunotherapy in two ongoing human clinical trials with a Phase II skin cancer basket trial planned for 2020.

We conclude season one of Underrated ML by having Stephen Merity on as our guest. Stephen has worked at various institutions such as MetaMind and Salesforce ohana, Google Sydney, Freelancer.com, the Schwa Lab at the University of Sydney, the team at Grok Learning, the non-profit Common Crawl, and IACS @ Harvard. He also holds a Bachelor of Information Technology from the University of Sydney and a Master of Science in Computational Science and Engineering from Harvard University.In this weeks episode we talk about the current influences of hardware in the field of Deep Learning research, baseline models, strongly typed RNNs and Alan Turings paper on the chemical basis of morphogenesis. Underrated ML Twitter: https://twitter.com/underrated_mlStephen Merity Twitter: https://twitter.com/SmerityPlease let us know who you thought presented the most underrated paper in the form below: https://forms.gle/97MgHvTkXgdB41TC8Links to the papers:“The Chemical Basis of Morphogenesis” - https://www.dna.caltech.edu/courses/cs191/paperscs191/turing.pdf"Strongly-Typed Recurrent Neural Networks” - https://arxiv.org/abs/1602.02218"Quasi-Recurrent Neural Networks" - https://arxiv.org/abs/1611.01576"An Analysis of Neural Language Modelling at Multiple Scales" - https://arxiv.org/abs/1803.08240Additional Links:Aleatory architecture / hysteresis: Why Birds Are The World's Best EngineersNear decomposability: Near decomposability and the speed of evolution / The Architecture of ComplexityGoogle's All Our N-gram are Belong to You from 2006

On today's episode we had an Interractive session with Dr. Simon Ereh on a very important topic: "Hepatitis E Virus ". Dr. Simon Ereh is a Senior Registrar in Infectious Diseases at the University of Calabar Teaching Hospital, Nigeria. A research assistant at the Institute of Health and Medical Research (INSERM), Unit of Morphogenesis and Antigenicity of HIV and the Hepatitis Viruses in France. He is an Erasmus Mundus Scholar for Infectious Disease and One Health. Connect with him via Twitter: @Donereh and LinkedIn: Simon Ereh.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.05.26.105015v1?rss=1 Authors: Bennison, S. A., Blazejewski, S. M., Liu, X., Toyo-oka, K. Abstract: Neurite formation is the earliest stage of neuronal morphogenesis, where primitive dendrites and the primitive axon emerge from a spherical neuron and begin to elongate. Defective neuritogenesis is a contributing pathogenic mechanism behind a variety of neurodevelopmental disorders. Activity-dependent neuroprotective protein (Adnp) is essential to embryonic and postnatal brain development, and mutations in ADNP are among the most frequent underlying autism spectrum disorder (ASD). We found that knockdown of Adnp in vitro and in vivo in mouse layer 2/3 pyramidal neurons leads to increased neurite initiation and defective neurite elongation, suggesting that Adnp has distinct roles in each. In vivo analysis revealed that deficits begin at P0 and are sustained throughout development, the most notable of which include increased neurite stabilization, disrupted angle of the apical dendrite, increased basal dendrite number, and increased axon length. Because small changes in neuronal morphology can have large-scale effects on neuronal function and connectivity, we performed ex vivo calcium imaging to assess spontaneous function of layer 2/3 pyramidal neurons deficient in Adnp. This revealed that Adnp deficient neurons had a greater spontaneous calcium influx and a higher proportion of cells firing action potentials. Next, we utilized GRAPHIC, a novel synaptic tracing technology, to assess interhemispheric cortical connectivity. We found increased interhemispheric excitatory connectivity between Adnp deficient layer 2/3 pyramidal neurons. Because Adnp is a multifunctional protein with both transcription factor and cytoskeletal activity, we performed localization analysis of Adnp as neurons underwent neurite formation to probe the mechanism of our morphological defects. We found that Adnp is shuttled from the nucleus to the cytoplasm upon differentiation and this shuttling can be blocked via application of a global 14-3-3 inhibitor, difopein. Furthermore, we found that Adnp binds nuclear-cytoplasmic shuttle 14-3-3{varepsilon}. We conclude that Adnp is shuttled from the nucleus to the cytoplasm by 14-3-3{varepsilon}, where it regulates neuronal morphology, maturation, cortical connectivity, and calcium signaling. Copy rights belong to original authors. Visit the link for more info

Morphogenesis Secret of God in Life Forms is explained in this episode. Listen to the podcast.Vazhga Valamudan,Be Blessed,Krish Murali Eswar.Visit https://www.simplifiedkundaliniyoga.com/ to awaken your Kundalini and mediate on your life-force to succeed in your life.Visit https://kayakalpayoga.com/ to transmute sexual energy into spiritual energy.Donatehttps://www.simplifiedkundaliniyoga.com/donateSupport the show (https://instamojo.com/@muralieswar)

One hundred years ago, D’Arcy Thompson – a nineteenth century polymath, working at the turn of the twentieth century – wrote a beautiful monograph, “On Growth and Form”, in which he pondered the geometry of living forms and how it emerges in the process of Morphogenesis. Thompson was ahead of his time. Genetics and Developmental Biology have since come a long way in elucidating the general and particular aspects of Morphogenesis, uncovering the key genes and molecules that underlie the process in different animals and plants. Yet, Thompson’s agenda of understanding how developmental processes actually specify the geometry of tissues, limbs and organs is far from complete. A particular challenge is to bridge the gap between microscopic scales, where molecular mechanisms operate, and the macroscopic scales of animal “shape and form”. This challenge offers much for a Theoretical Physicist to think about. This talk will provide some examples, relating the study of order in the arrangement of fly wing hairs to ferromagnetism and uncovering an unexpected wealth of mechanical phenomena in the study of cellular flows in a fly embryo.

NEIL GERSHENFELD (https://www.edge.org/memberbio/neil_gershenfeld) is the director of MIT’s Center for Bits and Atoms; founder of the global fab lab network; the author of FAB; and co-author (with Alan Gershenfeld & Joel Cutcher-Gershenfeld) of Designing Reality. The Conversation: https://www.edge.org/conversation/neil_gershenfeld-morphogenesis-for-the-design-of-design

Welcome to the Elevator World News Podcast. This week’s news podcast is sponsored by elevatorbooks.com: www.elevatorbooks.com TJEI LANDS LARGEST ORDER TO DATE Toshiba Johnson Elevators (India) Pvt. Ltd. (TJEI) recently announced winning its largest order to date in India for 128 elevators with 12-car group control system in Surat Diamond Bourse (SDB). The scope of work entails the supply, installation and maintenance of the units. The SDB, with a total built-up area of 620,000 m2, will become the single largest office building in the world, with 4,500 offices. “For the 15-story world’s single largest office building, designed to complement the diamond industry of Surat, enabling safe and easy navigation for large volumes of people is of prime importance," Junichi Kyushima, managing director, TJEI said. All the elevators will come with Destination Control Systems for seamless traffic handling. An elevator monitoring system is also one of the premium features being supplied by TJEI, along with interface provisions for access control, live TV, closed-circuit TV and more. Image credit: Rendering courtesy of Morphogenesis. To read the full transcript of today's podcast, visit: elevatorworld.com/news Subscribe to the Podcast: iTunes│Google Play | SoundCloud│Stitcher │TuneIn

Dia1-dependent adhesions help epithelia branch out The actin cytoskeleton and its regulators play key roles in the maturation and stabilization of focal adhesions but how adhesion maturation affects tissue morphogenesis is largely unknown. Fessenden et al. reveal that the actin-nucleating formin protein Dia1 promotes branching morphogenesis by stabilizing adhesions that are required for epithelial tissues to initiate invasion. This biosights episode presents the paper by Fessenden et al. from the April 2nd, 2018, issue of the Journal of Cell Biology and includes an interview with the paper's senior author, Margaret Gardel (University of Chicago). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research. Subscribe to biosights via iTunes or RSS View biosights archive The Rockefeller University Press biosights@rockefeller.edu

January 2018 Embodiment Lisa Renee Dear Ascending Family, This year begins the change in the law of structure in the planetary body referred to as Morphogenesis, which gives us opportunities to explore how these structural changes in energy to matter impact our manifestations. The physical body is extremely important during this stage, as what we are here to shift on the earth can only happen while we remain inside an ascending human body. We will look at the agenda behind Transhumanism to interfere with the true higher consciousness embodiment process during the Ascension Cycle. We will discuss the multiple sections of the bifurcated earth, changes in Guardian groups and the Rise of the Paliadorians, where some will begin to embody higher DNA imprints in order to return the earth to the rightful benevolent stewardship of loving Guardians.

El intérprete tunecino de oud Anouar Brahem reflexiona sobre su relación con el jazz y la comparte con tres músicos fundamentales: el contrabajista Dave Holland, el baterista Jack DeJohnette y el pianista Django Bates. En esta edición de 'Club de Jazz' del 8 de noviembre de 2017 escuchamos su disco "Blue Maqams" y nos reencontramos con el saxofonista Steve Coleman, que presenta "Morphogenesis" con su proyecto Natal Eclipse. Además, Fernando Ortiz de Urbina nos ofrece en "London Calling" dos grabaciones con presencia del contrabajista Oscar Pettiford. Toda la información y derechos: http://www.elclubdejazz.com

El intérprete tunecino de oud Anouar Brahem reflexiona sobre su relación con el jazz y la comparte con tres músicos fundamentales: el contrabajista Dave Holland, el baterista Jack DeJohnette y el pianista Django Bates. En esta edición de 'Club de Jazz' del 8 de noviembre de 2017 escuchamos su disco "Blue Maqams" y nos reencontramos con el saxofonista Steve Coleman, que presenta "Morphogenesis" con su proyecto Natal Eclipse. Además, Fernando Ortiz de Urbina nos ofrece en "London Calling" dos grabaciones con presencia del contrabajista Oscar Pettiford. Toda la información y derechos: http://www.elclubdejazz.com

8e émission de la 37e session... Cette semaine, Steve Swallow x2, du vieux nouveau jazz, postbop et modernité ! En musique: Tony Allen sur l'album A Tribute to Art Blakey & The Jazz Messengers  (Blue Note, 2017); Riverside sur l'album The New National Anthem  (Greenleaf, 2017); Jamie Saft, Steve Swallow, Bobby Previte With Iggy Pop sur l'album Loneliness Road  (RareNoise, 2017); Josephine Davies sur l'album Satori  (Whirlwind, 2017); Steve Coleman's Natal Eclipse sur l'album Morphogenesis  (Pi Recordings, 2017); Marcus Vergette sur l'album The Marsyas Suite  (Leo, 2017)...

8e émission de la 37e session... Cette semaine, Steve Swallow x2, du vieux nouveau jazz, postbop et modernité ! En musique: Tony Allen sur l'album A Tribute to Art Blakey & The Jazz Messengers  (Blue Note, 2017); Riverside sur l'album The New National Anthem  (Greenleaf, 2017); Jamie Saft, Steve Swallow, Bobby Previte With Iggy Pop sur l'album Loneliness Road  (RareNoise, 2017); Josephine Davies sur l'album Satori  (Whirlwind, 2017); Steve Coleman's Natal Eclipse sur l'album Morphogenesis  (Pi Recordings, 2017); Marcus Vergette sur l'album The Marsyas Suite  (Leo, 2017)...

Guest: Dr. Alison Hazelbaker is an expert on infant sucking issues caused by various structural problems like torticollis, plagiocephaly, brachycephaly and tissue shock-trauma. She designed the Assessment Tool for Lingual Frenulum Function (ATLFF), which is the only research-based tongue-tie screening process in infants under 6 months. In this episode, we will cover: When a tongue and/or lip tie revision is absolutely necessary and when it would be an unnecessary surgery for your baby (only 5% of babies have a true tongue tie) What problems are associated with tongue and/or lip tie for your baby (with breastfeeding and beyond) What questions you should ask your pediatrician, lactation consultant and/or pediatric dentist before you subject your baby to this surgery Resources mentioned in the conversation: Dr. Hazelbaker's website: http://www.alisonhazelbaker.com link to her book: Tongue-tie: Morphogenesis, Impact, Assessment and Treatment www.tongue-tie.org  About Dr. Alison Hazelbaker: Dr. Hazelbaker has been a therapist for over 30 years. She specializes in cross-disciplinary treatment and to that end has taken training in several modalities to best assist her clients. She is a certified Craniosacral Therapist, a Lymph Drainage Therapy practitioner, a Tummy Time™ Trainer, a Haller Method practitioner and an International Board Certified Lactation Consultant. She is recognized as an expert on infant sucking issues caused by various structural problems like torticollis, plagiocephaly, brachycephaly and tissue shock-trauma. She earned her Master’s Degree from Pacific Oaks College (Human Development specializing in Human Lactation) and her doctorate from The Union Institute and University (Psychology, specializing in Energetic and Transformational healing.) Her original research on tongue-tie, done in 1993, has changed clinical practice both in the USA and abroad. (www.tongue-tie.org) She authored the Assessment Tool for Lingual Frenulum Function (ATLFF) during her Master’s Degree program. She recently revised her Master’s thesis on tongue-tie into a comprehensive book on the condition: Tongue-tie: Morphogenesis, Impact, Assessment and Treatment for Aidan and Eva Press. www.aidanandevapress.com The ATLFF remains the only research-based tongue-tie screening process in infants under 6 months.

How Alan Turing's Reaction-Diffusion Model Simulates Patterns in Nature Thanks to http://www.audible.com/minuteearth for sponsoring this video. Asparagus Pee Survey Results: https://goo.gl/8x7abL ___________________________________________ If you liked this video, we think you might also like this: Reaction Diffusion Simulation (Gray-Scott model) https://pmneila.github.io/jsexp/grayscott/ ___________________________________________ Credits (and Twitter handles): Script Writer: Rachel Becker (@RA_Becks) Script Editor: Emily Elert (@eelert) Video Illustrator: Ever Salazar (@eversalazar) Video Director: Emily Elert (@eelert) Video Narrator: Emily Elert (@eelert) With Contributions From: Henry Reich, Alex Reich, Kate Yoshida, Omkar Bhagat, Peter Reich, David Goldenberg Music by: Nathaniel Schroeder: http://www.soundcloud.com/drschroeder Also, special thanks to the following scientists: Greg Barsh: Investigator, HudsonAlpha Institute for Biotechnology (http://goo.gl/RMD8o9) Jeremy Green: Professor of developmental biology, King’s College London (https://goo.gl/Qcn8Ay) Thomas Hiscock: Graduate student in systems biology, Harvard University (http://goo.gl/RbAWIy) Shigeru Kondo: Professor, Osaka University (http://goo.gl/uQ2wYO) James Sharpe: Coordinator of EMBL-CRG Systems Biology Unit and ICREA research professor (http://goo.gl/QCGul8) Ian Stewart: Emeritus professor of mathematics, University of Warwick and author of The Mathematics of Life (http://goo.gl/rGR1R0) Thomas Woolley: Postdoctoral scientist, St John's College Oxford (http://goo.gl/B4FZNn) Image Credits: - Mouse palate images provided courtesy of Jeremy Green, King’s College London. - Digit patterns image provided courtesy of Luciano Marcon and Jelena Raspopovic. - Angelfish and zebrafish images provided courtesy of Shigeru Kondo. _________________________________________ Subscribe to MinuteEarth on YouTube: http://goo.gl/EpIDGd Support us on Patreon: https://goo.gl/ZVgLQZ Facebook: http://goo.gl/FpAvo6 Twitter: http://goo.gl/Y1aWVC itunes: https://goo.gl/sfwS6n ___________________________________________ Here are some handy keywords to get your googling started: Reaction-diffusion system: A hypothetical system in which multiple chemical substances diffuse through a defined space at different rates and react with one another, thereby generating a pattern. Turing pattern: A periodic pattern that forms in a space where the initial distribution of ‘activator’ and ‘inhibitor’ is the same. Morphogenesis: The processes during development that give rise to the form or shape of the organism or a structure Alan Turing: Alan Turing was a British mathematician and the father of modern computer science. During World War II, he broke Germany’s Enigma code used to encrypt communications. ____________________ References: Economou, A. D., Ohazama, A., Porntaveetus, T., Sharpe, P. T., Kondo, S., Basson, M. A., … Green, J. B. A. (2012). Periodic stripe formation by a Turing-mechanism operating at growth zones in the mammalian palate. Nature Genetics, 44(3), 348–351. http://doi.org/10.1038/ng.1090 Economou, A. D., & Green, J. B. (2014). Modelling from the experimental developmental biologists viewpoint. Seminars in Cell & Developmental Biology, 35, 58-65. doi:10.1016/j.semcdb.2014.07.006 Green, J. B., & Sharpe, J. (2015). Positional information and reaction-diffusion: Two big ideas in developmental biology combine.Development, 142(7), 1203-1211. doi:10.1242/dev.114991 Kimura, Y. T. (2016, May 24). The mathematics of patterns. Retrieved from http://www.theshapeofmath.com/princeton/dynsys Kimura, Y. T. (2014). The Mathematics of Patterns: The modeling and analysis of reaction-diffusion equations (Thesis, Princeton University). Http://www.pacm.princeton.edu/documents/Kimura.pdf. Kondo, S., & Asai, R. (1995). A reaction-diffusion wave on the skin of the marine angelfish Pomacanthus. Nature, 376(6543), 765-768. doi:10.1038/376765a0 Kondo, S., & Miura, T. (2010). Reaction-Diffusion Model as a Framework for Understanding Biological Pattern Formation. Science, 329(5999), 1616-1620. doi:10.1126/science.1179047 Marcon, L., & Sharpe, J. (2012). Turing patterns in development: What about the horse part? Current Opinion in Genetics & Development, 22(6), 578-584. doi:10.1016/j.gde.2012.11.013 Raspopovic, J., Marcon, L., Russo, L., & Sharpe, J. (2014). Digit patterning is controlled by a Bmp-Sox9-Wnt Turing network modulated by morphogen gradients. Science, 345(6196), 566-570. doi:10.1126/science.1252960 Stewart, I. (2012). The mathematics of life. Philadelphia, PA: Basic Books. (https://goo.gl/IOagrs) Turing, A. M. (1952). The Chemical Basis of Morphogenesis. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, 237(641), 37-72. Retrieved from http://www.dna.caltech.edu/courses/cs191/paperscs191/turing.pdf

This conversation is with Adam Bohman who has been operating on the outer fringes of underground music for decades. Working with home-built instruments, found objects, tape cut-ups, collages, ink drawings and graphic scores. Favouring acoustic sounds over electronics, he explores the minute tendrils of sounds coaxed from any number of non-musical instruments and objects. He is a member of British experimental groups, Morphogenesis, The Bohman Brothers, Secluded Bronte, and The London Improvisers Orchestra. Adam's music is unique and experimental, incorporating Fluxus japery, musique concrete, sound poetry and free improvisation.  Show Notes: Adam mentioned the following: Charles Fox- jazz critic Toney Oxley Howard Riley Evan Parker Clifford Douse Robert Nut The cranium bunch Jonathan Bohman the cockpit improvised music workshop Cockpit Theatre Ian Macqueen Teddy Coleridge Fred Frith Keith Rowe Paul Pevan- Du Fuy Collective Hugh Metcalfe The Clinker Morphogenesis Rodger Sutherland Dave Jackman Morley college Ron Priefal Barry Anderson Phil Vaxman Conspiracy Nick Couldry Eddie Prevost- Matchless Recordings Intravenous- Album on Matchless Recordings John Telfer Andy Hammond Phil Wachsmann at City Lit Ian Smith- trumpet player Red Rose Club- Seven Sisters Road Time Out Cafe Oto Adrian Northover Robert Powell Tim Fletcher Wiesbaden John Russell Dirk Midvll- saxophonist Andy Holden (artist) Richard Thomas (Secluded Bronte) Bohman Brothers Extended Family Andy Brown- Wine glass player Dale Chilhuly (glass blower) Tom Jackson Michael Prime Clive Graham Clive Hall Ron Briefel Panos Ghikas Vitrine Tapes lan Mozek Sharon Gal My Dance The Skull The Junkie- William Burroughs Hornby Dvorak The Dumkey Tri Junkie Hornby Dumkey LMC-London Musician Collective The Clinker

  with Tiara Kumara...Go to Guided Audio Meditations for this module     Our complete transcendence from duality is paramount to catalyze many new and positive reflections that are so needed in our world today. When we change, our outer world changes too and pretty soon, this trendy lifestyle of human morphogenesis will be world scale. Always remember that when we focus all of our thoughts, words and actions on the highest good of all, we are operating in alignment with the Universe, and we begin to live, perceive and create from the Divine Consciousness within.Many blessings of grace on your forward journey of morphogenesis.

    with Tiara Kumara...Go to Guided Audio Meditations for this module   Our next and final module of the MORPHOGENESIS program regards one of the greatest perceptual shifts that we can ever make as an evolving human.  This has to do with transcending the concept that we call 'time'. We are opening the Seal of Transcendence by learning how to maneuver across the great divide and into a more spatial existence.

  with Tiara Kumara...Go to Guided Audio Meditations for this module     This next module of MORPHOGENESIS helps us to step on to a pathless path and to reveal our power from the void. We learn how to serve as an empty cup and from internal stillness, one of greatest self mastered states that there is.    

  with Tiara Kumara...Go to Guided Audio Meditations for this module     Through the program of Morphogenesis, we are learning how to gracefully evolve our consciousness through the higher senses, those that open as we embrace more expansive views. As 'Divine Humans'; we function through both the human senses and a more refined sensory mechanism that develops as a result of the opening crystalline seals. Inherent within us are certain mental faculties designed to bridge our human consciousness into the expanded realms of the multi-dimension. These divinely attuned instruments assist us to see beyond the form and to interpret our environment from a completely different feedback mechanism.

  with Tiara Kumara...Go to Guided Audio Meditations for this module     Through the program of Morphogenesis, we are learning how to gracefully evolve our consciousness through the higher senses, those that open as we embrace more expansive views. As 'Divine Humans'; we function through both the human senses and a more refined sensory mechanism that develops as a result of the opening crystalline seals. Inherent within us are certain mental faculties designed to bridge our human consciousness into the expanded realms of the multi-dimension. These divinely attuned instruments assist us to see beyond the form and to interpret our environment from a completely different feedback mechanism.

 with Tiara Kumara...Go to guided audio meditations for this module Your personality is impermanent; therefore, it is not real. It is only a minuscule reflection of its inclusive nature within another more expansive umbrella. The only real, lasting substance is that part of your consciousness that pristinely vibrates to an all-encompassing group tone. In essence, you are part of a bigger conglomerate comprised of many souls. Through this program of Morphogenesis, you will learn how to connect to and maneuver from your higher mind.  Your higher mind is a group mind, and this group mind is your greater aspect of Self.

with Tiara Kumara...MORPHOGENESIS is an educational curriculum designed to accelerate your transition into an evolved blueprint referred to as, the Avatar Consciousness. An Avatar is recognized as a sort of 'superhuman' due to the actualized supernal knowledge and mastery over the human program.   We are opening the biological 'Crystalline Seals' through a series of synergistic unlocking mechanisms purposed to activate dormant DNA encoding. This is an alchemical formula developed around a systematic process of release from the main carnal blocks that keep you bound to the human story.     

with Tiara Kumara... Get yourself unlocked! Your physical biology contains a treasure chest of cellular encoding that holds the template to your eternal magnificence. It's time to get your body universe released from the ironclad chains to experience a different reality of a much more colossal measure. Morphogenesis is an experience of sacred alchemy triggered through the elixir of expanded perception!

The podcast returns with Gomthog talking with drummer and songwriter Sean Lang about his latest project Seven Year Storm on February 28, 2015. Sean discusses his past and present, including his new album Aion I. Music credits: excerpt from "Morphogenesis" by Seven Year Storm (Aion I, 2015) used with permission from the artist. Photo credit: Sean Lang promo photo provided by Asher Media. www.facebook.com/thegreatmetaldebate www.youtube.com/channel/UCLC0ED1Ri2oNwBQW9All3Yw Have a question for the podcast, or a suggestion for an artist you'd like us to interview? Give us your feedback at: thegreatmetaldebate@gmail.com

What makes tigers striped and cheetahs spotty? World War II code-breaker and father of computing, Alan Turing, has a simple explanation…

Transcript -- What makes tigers striped and cheetahs spotty? World War II code-breaker and father of computing, Alan Turing, has a simple explanation…

Phosphoinositides get cells in shape Early Drosophila embryos undergo 13 rounds of rapid nuclear division before enclosing each nucleus into an individual, membrane-bound cell. Reversi et al. describe how the phosphoinositides PI(4,5)P2 and PI(3,4,5)P3 control the resulting cell shapes by coordinating actomyosin contractility with plasma membrane expansion. This biosights episode presents the paper by Reversi et al. from the May 12, 2014, issue of The Journal of Cell Biology and includes an interview with senior author Stefano De Renzis (EMBL, Heidelberg, Germany). Produced by Caitlin Sedwick and Ben Short. See the associated paper in JCB for details on the funding provided to support this original research. Subscribe to biosights via iTunes or RSS View biosights archive The Rockefeller University Press biosights@rockefeller.edu

Steve Rogers and Mark Peifer identify the G protein–coupled receptor Mist as the receptor for Fog, a secreted factor that drives gastrulation in fruit fly embryos.

The paddlefish or spoonbill (Polyodon spathula) is native to a number of large North American rivers, including the Ohio River. One remarkable feature of this awesome species is the prominent rostrum or paddle, an extension of the skull that grows rapidly soon after the fish hatch. Dr. Robertson will describe his collaborative research into the functional morphology and growth of the rostrum, including capstone projects and course-based studies.

Philip Maini, Oxford University, gives a talk for the Alan Turing Centenary weekend.

Englishman Dr. Rupert Sheldrake, author of *Dogs That Know When Their Owners Are Coming Home: And Other Unexplained Powers of Animals*, *A New Science of Life: The Hypothesis of Morphic Resonance* discusses his life, work and morphogenesis.

This episode features two of the key speakers from this year's SCHUNK Expert Days, Bruno Siciliano and Rolf Pfeifer. We took advantage of the stimulating conference atmosphere to ask them more about dexterous manipulators and morphogenesis.

In this episode of Futures in Biotech, Dr. Celeste Nelson, from Princeton University, explores the fundamental mechanisms of organ morphogenesis. Guest: Dr. Celeste Nelson, Ph.D. Guest Host: Andre Nantel, Ph.D. Host: Marc Pelletier We invite you to read, add to, and amend our show notes. Comments and suggestions on Futures in Biotech. Also thanks to Phil Pelletier and Will Hall for the great themes. Thanks to Cachefly for providing the bandwidth for this netcast. Sponsor: Ford Technology

In this episode of Futures in Biotech, Dr. Celeste Nelson, from Princeton University, explores the fundamental mechanisms of organ morphogenesis. Guest: Dr. Celeste Nelson, Ph.D. Guest Host: Andre Nantel, Ph.D. Host: Marc Pelletier We invite you to read, add to, and amend our show notes. Comments and suggestions on Futures in Biotech. Also thanks to Phil Pelletier and Will Hall for the great themes. Thanks to Cachefly for providing the bandwidth for this netcast. Sponsor: Ford Technology

Science

Through the Gates of Delerium and into the Dark Abyss, singing as we go. An appropriate metaphor for the imminent passing of 2009 and the impending arrival of 2010... with music from SynC, Michael Bruckner, Morphogenesis and Yes.

Through the Gates of Delerium and into the Dark Abyss, singing as we go. An appropriate metaphor for the imminent passing of 2009 and the impending arrival of 2010... with music from SynC, Michael Bruckner, Morphogenesis and Yes.

Enhanced Audio PodcastAired date: 3/18/2009 3:00:00 PM Eastern Time

Enhanced Video PodcastAired date: 3/18/2009 3:00:00 PM Eastern Time

Fri, 14 Dec 2007 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/7852/ https://edoc.ub.uni-muenchen.de/7852/1/Reissaus_Andre.pdf Reissaus, Andre

Wed, 12 Sep 2007 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/7427/ https://edoc.ub.uni-muenchen.de/7427/1/Shivalkar_Madhuri.pdf Shivalkar, Madhuri

Sept 29, 2005. The 3rd recorded lecture in my Philosophy and Computers course, covering the first half of Chapter 3 of The Lifebox, the Seashell, and the Soul, see www.rudyrucker.com/lifebox. I talk about self-reproduction, intelligent design, morphogenesis, and ecology in terms of computations. By the way, my Philosophy class lectures are more or less independent […]

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Fri, 1 Jan 1993 12:00:00 +0100 http://epub.ub.uni-muenchen.de/5968/ http://epub.ub.uni-muenchen.de/5968/1/5968.pdf Siegert, Florian; Weijer, Cornelis J. Siegert, Florian und Weijer, Cornelis J. (1993): The role of periodic signals in the morphogenesis of Dictyostelium discoideum. In: Rensing, Ludger (Hrsg.), Oscillations and morphogenesis. Dekker: New York, pp. 133-152. Geowissensc

Cells in Dictyostelium slugs follow well-defined patterns of motion. We found that the chemotactic cell response is controlled by a scroll wave of messenger concentration in the highly excitable prestalk zone of the slug that decays in the less-excitable prespore region into planar wave fronts. This phenomenon is investigated by numerical solutions of partial differential equations that couple local nonlinear kinetics and diffusive transport of the chemotactic signal. In the interface of both regions a complex twisted scroll wave is formed that reduces the wave frequency in the prespore zone. The spatio-temporal dynamics of waves and filaments are followed over 33 periods of rotation. These results yield an explanation of collective self-organized cell motion in a multicellular organism.

Differentiation of sensory nerve cells in tentacles of Hydra magnipapillata was investigated using the monoclonal antibody NV1. NV1+ sensory nerve cells form specific complexes with battery cells in tentacles. NV1+ cells can only be formed by differentiation from interstitial cell precursors. These precursors complete a terminal cell cycle in the distal gastric region at the base of tentacles; differentiation from the S/G2 boundary to expression of the NV1 antigen requires 30h. During this time, precursors move from the distal gastric region into the tentacles, differentiate to morphologically fully formed nerve cells and then begin expressing NV1 antigen. The neuropeptide head activator stimulates NV1+ differentiation in S-phase of the precursor's cell cycle.

Stimulation of tentacle-specific cell differentiation by the neuropeptide head activator was investigated in Hydra magnipapillata. Tentacle-specific sensory nerve cells were identified by a monoclonal antibody, NV1. Treatment of hydra with 1pM head activator for 18h stimulated differentiation of NV1+ nerve cells and tentacle epithelial cells in tissue from the distal gastric region. Head tissue and tissue from the proximal gastric region did not respond to head activator treatment with increased NV1+ differentiation. Hence the distal gastric region appears to be the site of tentacle formation in hydra. Tentacle precursors in head tissue seem to be committed since they fail to respond to head activator or to changes in tissue size with altered amounts of tentacle formation. We suggest that NV1 precursors form a complex with tentacle epithelial cell precursors, which then moves distally through the head region into the tentacles. The signal for NV1+ differentiation appears to be formation of this complex.

Two modes of assembly of murine cytomegalovirus (MCMV) were observed in cultured mouse embryo fïbroblasts, generating two morphologically different types of viral particles: monocapsid virions and multicapsid virions. The assembly of nucleocapsids appeared to be the same for both types of morphogenesis. Three successive stages of intranuclear capsid formation could be distinguished: capsids with electron-lucent cores, coreless capsids, and capsids with dense cores. Some of the capsids were enveloped at the inner nuclear membrane to form monocapsid virions, which were first detectable in the perinuclear cisterna. Other capsids left the nucleus via nuclear pores and usually entered cytoplasmic capsid aggregates that received an envelope by budding into extended cytoplasmic vacuoles, thereby forming multicapsid virions. Since the formation of multicapsid virions is not restricted to cell culture conditions and also occurs in vivo in immunosuppressed mice, multicapsid virions may play a role in the pathogenesis of cytomegalovirus infection.

Tissue maceration was used to determine the absolute number and the distribution of cell types in Hydra. It was shown that the total number of cells per animal as well as the distribution of cells vary depending on temperature, feeding conditions, and state of growth. During head and foot regeneration and during budding the first detectable change in the cell distribution is an increase in the number of nerve cells at the site of morphogenesis. These results and the finding that nerve cells are most concentrated in the head region, diminishing in density down the body column, are discussed in relation to tissue polarity.