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CHECK OUT OUR WEBSITE FAT LOSS GUIDE- www.colossusfitness.com1- Eat MindfullyPay attention to what and how much you're eating. Avoid distractions like watching TV or using your phone while eating. Chew your food slowly and savor each bite.2- EAT BETTER FOOD!!!Prioritize protein, eat enough fibre & drink lots of water3- Understand the difference between tolerable and intolerable hungerTolerable Hunger: You're hungry, but still in control. You can focus, function normally, and wait until your next meal.Intolerable Hunger: Hunger is consuming your thoughts. You're irritable, distracted, and likely to overeat when food becomes available.4- Get rid of the liquid/empty/garbage caloriesFill up with more low calorie5- Have regular consistent meals & be in a reasonable deficitAs Huberman says, “eat like an adult.”Eating regular, balanced meals and snacks can help stabilize blood sugar levels and prevent extreme hunger, which can lead to overeating.6- Manage Stress & Get Enough SleepLack of sleep can disrupt hunger hormones, leading to increased appetite. Aim for 7-9 hours of quality sleep per night.Listed points:Thanks for listening! We genuinely appreciate every single one of you listening.➢Follow us on instagram @colossusfit➢Apply to get your Polished Physique: https://colossusfitness.com/

Can a 95% exchange to listings ratio really be achieved? I'm joined by Charlie Lamdin of Best Agent to discuss creating buyer competition, reducing fall throughs, improving conversion rates, and challenging traditional estate agency thinking to achieve faster sales and stronger results.

Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Internet sleuths just pulled permits for a brand new building in the Dark Universe portal at Epic Universe. Building 1570. Area 680. Listed as a special project. And the building numbers line up with exactly the kind of show building you'd need for a new attraction. Mike and EB have a theory about what it is — and it involves a glass bottom boat, the Creature from the Black Lagoon, and an idea that Coaster Radio listeners actually designed in a Real Design Contest years ago. If Universal puts a Coaster Radio t-shirt on one of the bodies in that ride, that's all the confirmation the show needs. Before the speculation though — Hagrid's Magical Creatures Motorbike Adventure has been removed from Universal Express. The longest line at Epic Universe is now a standby-only experience, and the people paying for Express Pass are not happy about it. Nate Bargatze wants to build a theme park based on his own life in Nashville and EB has thoughts. And RMC's Wild Moose prototype track has appeared at their Idaho headquarters, with the most interesting theory being that it could go indoors at Kentucky Kingdom in the space that used to hold a Schwarzkopf coaster. Then in the second half — the interactive question that started with Verbolten's new overlay at Busch Gardens Williamsburg produces one of the best listener response segments of the season. Rides that could use a refresh. Listeners suggest Journey to Atlantis, Men in Black Alien Attack, Dinosaur at Animal Kingdom, Flight of Fear, Big Thunder Mountain, the Haunted Mansion, Test Track, and the entire frontier area at Cedar Point. Mike and EB debate each one — and somewhere in the Men in Black discussion, EB invents what might be the greatest unused attraction concept in Universal history. Also — EB is going to Kentucky Kingdom on June 10th, there are collectible pins being considered, and the show closes with a detailed discussion of the 1997 horror film Wishmaster that you absolutely did not see coming. Stay through the Patreon section. You'll understand why.

Welcome to the Wholesale Hotline Podcast Weekend Edition (Flipping Mastery Edition), where Jerry teaches how to master the art of house flipping, wholesaling, and new construction development.Show notes -- in this episode we'll cover:Straightforward, step-by-step training on making six and seven figures from real estate deals.Insider tactics for finding motivated sellers, analyzing deals, and raising private money.Learn how to flip houses virtually from anywhere—even with zero experience.Whether you're a beginner or scaling up, Jerry gives you the blueprint to build real wealth through real estate.  Please give us a rating and let us know how we are doing!➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖ ☎️ Welcome to Wholesale Hotline & Flipping Mastery Breakout! ☎️Jerry Norton went from digging holes for minimum wage in his mid 20's to becoming a millionaire by the age of 30. Today he's the nation's leading expert on flipping houses and has taught thousands of people how to live their dream lifestyle through real estate. **NOTE: To Download any of Jerry's FREE training, tools, or resources…Click on the link provided and enter your email. The download is automatically emailed to you. If you don't see it, check your junk/spam folder, in case your email provider put it there. If you still don't see it, contact our support at: support@flippingmastery.com or 888) 958-3028. ➖➖➖➖➖➖➖➖➖➖➖➖➖➖➖ 

Link Up w/The Morning Sickness Digitally All Over:Instagram: @hms_98_official, @bosskupd, @bretvesely, @dickToledoX/Twitter: @HMSon98, @DickToledo, @bretveselyFacebook: @HMSKUPDYouTube: @hmspodcast9320, @98kupdRequest/Call in/Wakeup Song line:(IN AZ) 602.585.9800More HMS: holmbergpodcast.com, 98kupd.comEmail: dtoledo@98kupd.com, bvesely@98kupd.com, bbogen@98kupd.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Matt O'Leary discusses the New York Jets head coach being listed as a big winner after the 2026 schedule dropped Sign up for PrizePicks with code: HMA and get $50 in lineups instantly when you play your first $5+ lineup! https://link.prizepicks.com/LME0/OLEARY Find LUCY near you at lucy.co/stores, or save 20% on your first online order at lucy.co/HMA with promo code HMA. Play in my Free to Play Win $100 on PeopleGuess: https://www.peopleguess.com/ All videos now available in Podcast Form: Apple : http://bit.ly/3V7KcNQ Spotify : https://bit.ly/4mc8bX7 le Chrome Extension: https://www.swvle.com/r/G7cAw5VyQ1tv Subscribe to the Talkin Jets Channel: https://www.youtube.com/@TalkinJets/ For Serious Inquiries: mattoleary95@gmail.com MattOLearyNY Merch Shop: https://mattolearyny.com Social: Twitter: https://twitter.com/mattolearyny TikTok: https://www.tiktok.com/@mattolearyny?is_from_webapp=1&sender_device=pc Instagram: https://instagram.com/mattolearyny ​ Call in and leave a voicemail: ‪(631) 517-0756‬ JUST JETS PODCAST: https://linktr.ee/justjets MUSIC - Saint Saxon Sound Lia Saint Saxon - Lofi Hip Hop Beats to Relax/Study to https://www.youtube.com/watch?v=9uuBuZy0pxE&t=2314s Saint Saxon Sound Youtube Channel: https://bit.ly/3CWknIA Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Link Up w/The Morning Sickness Digitally All Over:Instagram: @hms_98_official, @bosskupd, @bretvesely, @dickToledoX/Twitter: @HMSon98, @DickToledo, @bretveselyFacebook: @HMSKUPDYouTube: @hmspodcast9320, @98kupdRequest/Call in/Wakeup Song line:(IN AZ) 602.585.9800More HMS: holmbergpodcast.com, 98kupd.comEmail: dtoledo@98kupd.com, bvesely@98kupd.com, bbogen@98kupd.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Sixtysomething - Season Two-Ep 27_Season Finale - Where Have I Been?In this short special episodeof Sixtysometing, I'm checking in to say hello, share where I've been, and talk a little about what's ahead for the podcast. Over the break, I've spent a lot of time thinking about this community, the conversations we've been having, and the things that matter most to us in this season of life.As we head toward a brand-new season of Sixtysomething, we'll continue talking about friendship, family, reinvention, purpose, creativity, legacy, starting businesses after 60, staying connected to the people we love, and finding joy—even when life gets messy or complicated.Most of all, I want this podcast to continue feeling like a real conversation between friends.You'll hear:• Why I took a little break• What I've been thinking about lately• Topics coming up in future episodes• Why authenticity matters more to me than ever• A reminder that none of us are figuring this stage of life out aloneContact InformationWebsite:https://www.sixtysomething.netFacebook Group:Sixtysomething Podcast CommunityEmail:grace@sixtysomething.net* * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Hey Friends! It's me, Grace! I just want to thank you for listening. I hope you'll let me know what you think about the podcast and if any particular episodes resonate with you. Listed just below here is my contact information and all of the social channels where you can find me, as well as the link to our Facebook Group. Contact InfoGrace Taylor SegalEmail: grace@gracetaylorsegal.comFacebook: 60something Page (https://www.facebook.com/profile.php?id=61553062496332)Instagram: @60somethingpodFacebook Group: 60Something Podhttps://www.facebook.com/groups/1665326354000332CreditsSixtysomething Theme SongMusic & lyrics by Lizzy SanfordVocals by Lizzy SanfordGuitar: Lizzy & Coco SanfordTo Leave a Review: On Apple Podcasts (no link is available--here are the steps)Open the Apple Podcasts app. Search for the podcast you want to review. Select the podcast show page (not an individual episode). Scroll to the bottom of the page. Click "Write a Review". On the Sixtysomething Podcast Websitehttps://www.sixtysomething.net/reviews/new/Thank you so much for taking the time to review the show!Timestamps:00:00 Welcome Back01:10 Why I Took a Break02:40 What's Ahead for Sixtysomething04:30 The Conversations We'll Be Having Together05:45 Thank You for Being Here

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This week Nick talks to Scott Lane Scott is the Founder and CEO of Speeki and serves as its Principal Auditor. He brings more than 25 years of experience in governance, compliance, and ESG risk, having built and scaled international businesses focused on helping organisations strengthen risk management and stakeholder trust.  After working for Sun Microsystems and Hitachi, Scott founded The Red Flag Group in 2006, where he served as CEO and Chairman. Under Scott's leadership, the company became a globally recognised expert in risk and compliance, advising many of the world's largest organisations. Scott exited the business in 2020 when The Red Flag Group became part of London Stock Exchange Group following its acquisition by Refinitiv. Nick and Scott discuss how audit and assurance capabilities have expanded from governance and compliance into broader ESG and sustainability reporting. They explore the growing need for independent verification of ESG claims, alongside the evolving global debate around ESG regulation, reporting, and governance standards. Book Choice Good To Great by Jim CollinsMusic ChoiceBruno Mars, FKA twigs, Nine Inch Nails, BIGBANG, Karol G & David GuettaThis content is issued by Zeus Capital Limited (“Zeus”) (Incorporated in England & Wales No. 4417845), which is authorised and regulated in the United Kingdom by the Financial Conduct Authority (“FCA”) for designated investment business, (Reg No. 224621) and is a member firm of the London Stock Exchange. This content is for information purposes only and neither the information contained, nor the opinions expressed within, constitute or are to be construed as an offer or a solicitation of an offer to buy or sell the securities or other instruments mentioned in it. Zeus shall not be liable for any direct or indirect damages, including lost profits arising in any way from the information contained in this material. This material is for the use of intended recipients only.

-Staples wrote this weekend these 10 storylines, in order, that are most meaningful: 1) The Legend of Arch Manning; 2) Lane Kiffin'sFirst Year at LSU; 3) Is Mike Norvell in his last year at FSU?; 4) Lincoln Riley's “window;” 5) 5-star QBs taking the SEC by storm-6) Young coach takeover in the SEC; 7) Change of the guard in the B1G?; 8) What happened to Clemson?; 9) Texas Tech's BrendanSorsby situation; and 10) Deion Sanders and Colorado's next moveOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

-Staples wrote this weekend these 10 storylines, in order, that are most meaningful: 1) The Legend of Arch Manning; 2) Lane Kiffin'sFirst Year at LSU; 3) Is Mike Norvell in his last year at FSU?; 4) Lincoln Riley's “window;” 5) 5-star QBs taking the SEC by storm-6) Young coach takeover in the SEC; 7) Change of the guard in the B1G?; 8) What happened to Clemson?; 9) Texas Tech's BrendanSorsby situation; and 10) Deion Sanders and Colorado's next moveOur Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

In this episode, I sit down with Rick N3FJZ — a prolific homebrew builder known in the SolderSmoke community for his meticulous construction, clean schematics, and commitment to all-discrete analog design. We trace his journey from his first scratch build projects to his current tranciever with a custom front panel digital display.Join us as we explore how you can get involved in portable radio, QRP, and more in this episode of the All Portable Discussion Zone (AP/DZ). Every aspect of portable operations is covered in this biweekly podcast, from news and gear to achievements, the workbench, contests, awards, and beyond.Rick's website: http://www.remmepark.com/circuit6040/Show notes Listed on Rick's Website: http://www.remmepark.com/circuit6040/Show_Notes/Show_Notes.html#apdz #SOTA #POTA #PortableOps #HamRadio #QRP #Workbench #Electronics #homebrewradio #DIYradio #testequipment #RFprojects #amateurradio #hamradiopodcast #scratchbuild #ManhattanStyle #BITX #SolderSmoke #HFtransceiver #QRPSSB #directconversion #analogradio

-Nebraska will end up probably between 8 th to 11 th on almost every list you see for the B1G in power rankings, so 8 th is nice to see fromESPN, who basically said Nebraska has had good starts under Matt Rhule—but November has been a problem and needs to be fixed-The real story is who is at No. 4---OHIO STATE!!—behind Indiana, Oregon, and USC. Now THAT would be a story if they fell thatfar…does The Stool see that happening? Between Ohio State and Nebraska is Penn State, Michigan, and Iowa…Our Sponsors:* Check out Hims: https://hims.com/EARLYBREAKAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Kait LeDonne is a New York-based personal branding strategist and LinkedIn coach who helps thought leaders, executives, and corporate teams turn expertise into visible authority, influence, and qualified deal flow. She is a featured instructor for CNBC Make It's "How to Build a Standout Personal Brand," bringing practical executive-grade playbooks to a broad audience.   Her LinkedIn audience and "Build a Brand" newsletter community exceed 80,000 professionals. She has delivered training for organizations, including the United States Air Force and Kia. Listed by Favikon among the Top Personal Branding Influencers in the U.S., Kait is frequently cited in the media for clear, results-driven personal brand strategies professionals can sustain.   Connect with Kait LeDonne:   Website: www.kaitledonne.com Linkedin: @kaitledonne   Episode Summary:   In this episode, host Lyndsay Dowd sits down with New York-based personal branding strategist Kait LeDonne — a LinkedIn coach with 80,000+ followers, CNBC contributor, and newsletter founder — to break down exactly how executives, consultants, and thought leaders can stop being the best-kept secret in their industry. Kait shares how she went from a corporate marketing role to launching her own business within 90 days, all powered by LinkedIn. The conversation covers LinkedIn's newest AI-driven algorithm, the three content pillars every professional needs, and how to convert visibility into real revenue — without ever feeling salesy.   Key takeaways:   Your expertise is already there — the gap is visibility, and the key is clarity. You don't need more credentials; you need a clearer message.  Personal branding isn't about being everywhere. It's about being unmistakable somewhere. Pick two to three topics and own them consistently. LinkedIn isn't just a resume — it's a revenue channel. Turning on your Services section, showcasing packages, and adding a soft CTA in posts can quietly drive real deal flow. Don't confuse engagement with your niche. A viral personal story proves you're human, not that you should pivot your entire brand toward it. Think like a reporter covering your own career. Your daily work is more fascinating to outsiders than you think — mine your schedule for content instead of waiting for big wins.   Episode chapters:   0:00 Cold open & episode preview 0:44 Introducing Kait LeDonne 2:11 Kait's origin story 4:50 Personality on LinkedIn — the three Ps framework 9:21 Three tactical tips for LinkedIn beginners 13:21 LinkedIn as a revenue channel 16:23 What most people get wrong — the reporter mindset 19:31 LinkedIn video — what's really happening 23:29 Kait's ideal clients & what makes brands fly 25:38 What inspires Kait — and her legacy 28:03 Where to find Kait  

17.3 mph Is the listed speed limit...yes 17.3 mph and drivers reactions to it are not what you think

This week Nick talks to Alistair SmallwoodAlistair Smallwood is the Head of Applied AI at Primer AI, where he focuses on building practical artificial intelligence tools for investment workflows. He began his career as a research analyst at Whitman Howard shortly after the Brexit vote, before moving into equity sales roles and later joining UBS as a pan-European small- and mid-cap specialist salesperson. He subsequently transitioned to the buy side with Lynott Partners, a technology-focused hedge fund, where he combined his financial expertise with self-taught coding skills to explore data-driven investing.The discussion centres on how Primer AI is transforming equity research through AI-driven agents that replicate and augment the workflow of human analysts. While AI can commoditize access to information, the true edge in investing lies in workflow, judgment, and behavioural insight—areas where human expertise remains critical. Primer AI is designed not just to retrieve accurate financial data, but to guide analysts through modular research processes, from understanding company fundamentals to building and interpreting financial models. The platform emphasizes auditability, context retention, and continuous learning, enabling users to encode their own analytical frameworks and improve efficiency over time. The conversation also explores broader implications for financial markets, suggesting that AI may compress short-term alpha opportunities while increasing the importance of long-term thinking and differentiated judgment. Alistair Book Choice's Endurance by Alfred LansingNo Spin: My Autobiography by Shane WarneAlistair Music Choice's Dark Side of the Moon by Pink FloydMoney for Nothing by Dire Straits from Brothers in Arms The Thinking Game - Documentary about DeepMind and Demis HassabisThis content is issued by Zeus Capital Limited (“Zeus”) (Incorporated in England & Wales No. 4417845), which is authorised and regulated in the United Kingdom by the Financial Conduct Authority (“FCA”) for designated investment business, (Reg No. 224621) and is a member firm of the London Stock Exchange. This content is for information purposes only and neither the information contained, nor the opinions expressed within, constitute or are to be construed as an offer or a solicitation of an offer to buy or sell the securities or other instruments mentioned in it. Zeus shall not be liable for any direct or indirect damages, including lost profits arising in any way from the information contained in this material. This material is for the use of intended recipients only.

NBA duos tier list! #nba   Check out the TD3 merch: https://the-deep-3-shop.fourthwall.com/   Listen on Spotify!: https://open.spotify.com/show/3elbbqVumwqz8wlIdknsLW   Listen on Apple Podcasts!: https://podcasts.apple.com/us/podcast/the-deep-3-podcast/id1657940794   Follow us on TikTok!: https://www.tiktok.com/@thedeepthree   Follow us on Instagram!: https://www.instagram.com/thedeep3podcast/   Isaac's twitter: https://twitter.com/byisaacg   Mo's twitter: https://twitter.com/Mojo99_   Donnavan's twitter: https://twitter.com/Dsmoot3D Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Jason Duncan built a seven-figure business, then lost it all in one year because it depended on him, and discovered how to exit without selling. In this special episode, host Anthony sits down with Jason Duncan, author of Exit Without Exiting and founder of The Exit, a mastermind helping entrepreneurs build businesses that don't need them. After hitting a million-dollar EBITDA and preparing to sell, Jason's business coach told him the brutal truth: "The reason you want out is the same reason no one wants in — the business is too dependent on you." One year later, a partner split consumed 75% of Jason's attention, and the business went from seven-figure profits to losing money. This led to an 18 month journey to systematically remove himself from daily operations without selling the company. This created the "exit without exiting" methodology that now helps hundreds of entrepreneurs do the same. Jason breaks down the three tiers of entrepreneurial evolution. This conversation dives into: Why 83% of businesses listed for sale never sell (and 73% fail because of owner dependence) The painful truth: going from $1M EBITDA to losing money in 12 months Three tiers of entrepreneurial evolution: owner operator → owner manager → owner investor Why you can't become a billionaire entrepreneur as an owner operator The dog doorbell analogy: you've trained your team to be dependent on you Activity over asset: the tier-one trap 90% of entrepreneurs never escape How Jason gave his leadership team five-figure raises to run daily operations without him Strategic disentanglement The dashboard approach SOPs are NOT training manuals The "locking Jason in his office" story From six one-on-ones per week to four (99% isn't about task management anymore) Why the first draft of Exit Without Exiting sucked Edward's story: tier-one owner operator stuck in a brutal five-year earnout Cheryl's story: maximum exit at the cost of 10 years with her kids James's story: the exit lifestyle from day one (less money, best life) Percent of income: the one P&L column that lets you run the business from a dashboard AI and SOPs: using Claude to write standard operating procedures The Exit mastermind criteria: $3M revenue or $300K EBITDA, US-based, coachable Two monthly Zoom meetings, weekly office hours, 24/7 chat group with six coaches Three live workshops per year in Nashville + biennial retreats Time vs. money: why time is the non-renewable resource AI helps you reclaim If you've ever felt trapped in your own business, realized you built a job with a logo, or discovered that nobody wants to buy what you've built — this episode will show you the exact system to build a business that runs without you.

In Episode 312 of The Block Runner Podcast, hosts William, I-man, and TJ unpack a wild week for $NAT: overnight listings on three centralized exchanges with zero fees paid, a god-candle to a $150M market cap, and a deeper, more rigorous walk-through of the Bitcoin security-budget math than the show has ever done on-air. They run the numbers through Michael Saylor's $441 trillion scenario, show why fees can't close the gap, and lay out the case for NAT as a supplementary second subsidy capable of delivering $2.1B/day to miners. The episode closes with a commitment: the next video from The Block Runner is NAT.fun going live. Disclosure: William and I-man are founders of NAT.fun and hold NAT tokens. All analysis in this episode reflects their perspective as participants in the ecosystem. Key topics: NAT token listed on MEXC, LBank, and CoinEx overnight — a fourth exchange followed the next day — with no listing fees paid, consistent with Constantinople-era organic exchange adoption The god-candle: NAT market cap to ~$150M in an instant, flipping ORDI; hosts normalize expectations to a new ~$40–$60M floor with extreme volatility still ahead Bankless on the Bitcoin security budget: Justin Drake's ultrasound-money framing, why "add tail issuance or move to proof-of-stake" is not a viable answer for Bitcoin The full math walkthrough: at $100T market cap in 30 years, Bitcoin delivers only $116K per block — roughly half of today's $243K — a ~0.00006% security-to-value ratio Running it through Michael Saylor's $441T scenario: five halvings out, Bitcoin still delivers only $2M/block and spends 0.0002% of its market cap on security — 100x below the U.S. 3.4% GDP-to-security benchmark Why "fees will cover it" doesn't math out: $10,781 per transaction, every block, every day, forever, to approximate a U.S.-equivalent security ratio on a $100T BTC NAT as a second subsidy: decoupled from Bitcoin's exponential decay, earned by miners alongside BTC, and still delivering in 2140 when subsidy hits zero The efficiency comparison: at a $15T NAT market cap paired with Saylor's $441T BTC, NAT delivers ~$285M/block — 100x more than BTC at the same point in time The on-air correction and the natgmi.com slider: at $1T NAT, miners receive $15M/block — 7x Bitcoin's current efficiency — or $2.1B/day Why the hosts can't be the messengers: the token-founder conflict and the need for a neutral Andreas-style explainer to carry the math to Bitcoin's mainstream NAT.fun preview and network-effect thesis: why the launch platform's success underwrites NAT's long-run demand, and why the hosts are going silent until it ships — the next video IS the launch Do the math yourself. If you arrive somewhere different, bring it into the comments. Please like and subscribe on your favorite podcasting app! Sign up for a free newsletter: www.theblockrunner.com Follow us on: Youtube: https://bit.ly/TBlkRnnrYouTube Twitter: bit.ly/TBR-Twitter Telegram: bit.ly/TBR-Telegram Discord: bit.ly/TBR-Discord $NAT Telegram: https://t.me/dmt_nat

Tickets for soccer's biggest global event in the US continue to swell, with some being re-listed for seven figures. Correspondent Gethin Coolbaugh reports.

Job site Seek has seen a big jump in the number casual roles listed on its website, as an economist says uncertain economic times are making businesses reluctant to hire full time staff. In theory, casual contracts offer flexibility for employer and employee, and work is available as and when it suits both parties - but no hours are guaranteed. Some workers also say the benefits can be stacked in favour of the employer, and the fluctuating hours make it difficult to get by. Luka Forman with this report.

In the 958th episode of the PokerNews Podcast, Chad Holloway, Mike Holtz, and Ben Ludlow are back to talk about a poker mystery. How did Esther Taylor's 2022 WPT Wynn trophy end up on eBay without her knowledge? Chad actually brought it to her attention, and after some investigating, there are more questions than answers. Was the trophy stolen? Hear from Etay herself as she shares what she thinks happened. From there, they talk about WrestleMania weekend in Las Vegas, which included Jared Bleznick (AKA Blez) meeting WWE superstar The Miz and discussing a $1.5 million sports card. From there, it's a look back at online poker's Black Friday on its 15th anniversary, plans for the 2026 World Series of Poker (WSOP), a big win by poker photographer Katerina Lukina, and winners from the 2026 PGT U.S. Poker Open, including Brock Wilson and Joao Simao. Finally, Chad shares video highlights from his trip to the record-setting Irish Open in Dublin. Find out all about those stories and more in this week's episode of the PokerNews Podcast! A new PokerNews Podcast drops every Thursday at 8a PT / 11a ET / 4p UK time. Remember to subscribe to our YouTube channel so you do not miss an episode! Time Stamps *Time    Topic* 00:00 | Welcome to the show 01:20 | Etay's trophy on eBay 05:08 | Hear what Etay has to say 08:00 | Missing poker memorabilia 10:38 | WrestleMania Weekend 10:53 | Blez meets Miz 12:47 | Black Friday 15th Anniversary 18:20 | US Poker Open winners 21:44 | Past US Poker Open champions 23:10 | Congrats to Katerina Lukina 25:25 | Plans for the 2026 WSOP 28:40 | Chad at the Irish Poker Open

Welcome to the Elevated Magazines Luxury Report powered by Timberlane, 30 years crafting the finest shutters, Timberlane.com. Today we're going deep into Southern California — one of the world's great luxury real estate markets, and right now one of its most active. Whether you're a buyer, a seller, or simply a devotee of the California good life — this is Elevated. Let's get into it.Southern California's luxury real estate market is performing with the specific confidence of a market that knows exactly what it is and what it offers. Limited inventory at the top end, consistent demand from domestic and international buyers, and the fundamental appeal of the California lifestyle continue to support values at every price point above eight figures. Two listings currently on the market represent exactly what Southern California luxury looks like at its most exceptional.The first is one of the most extraordinary homes to come to market on the Westside this year. Casa Princeton — 843 Princeton Street in Santa Monica — is a fully restored 1936 Spanish home originally designed by renowned local architect Cecil Gale, set in Santa Monica's tightly held, tree-lined Collegiate streets. The current owners — internationally award-winning architects, designers, and hoteliers — have restored Casa Princeton with a deep passion for its architectural history and an uncompromising focus on quality of life. The result is a Mediterranean retreat in the heart of the city. The fully gated and hedged property includes a 4-bedroom main residence, a permitted guest house, a heated saltwater swimming pool, organic market gardens, and alfresco dining areas designed in collaboration with award-winning landscape architect P. Keningale. Timeless craftsmanship defines every detail — hand-troweled plaster walls, cast bronze hardware, custom Farrow and Ball colors, original oak floors, and an original Spanish fireplace. The sun-drenched chef's kitchen features AGA, Miele, and Thermador appliances. The primary suite opens to a terracotta terrace and pool via French doors. A home where you feel your best self. Listed at $6,595,000. Represented by Cindy Ambuehl, CindyAmbuehl.com, Christie's International Real Estate Los Angeles.The second listing takes us south to Manhattan Beach's prestigious Hill Section, where 109 South Poinsettia Avenue offers panoramic ocean views stretching from Palos Verdes to Catalina on an oversized 7,503 square foot lot. This 5,586 square foot Mediterranean estate combines timeless architecture, exceptional space, and the coastal indoor-outdoor lifestyle that makes the Hill Section one of the most coveted addresses in California. A dramatic entry with travertine floors and a sweeping curved staircase sets the tone throughout. The main living level captures the panoramic views — featuring the kitchen, formal dining room, an ocean-view office with custom built-ins, theater room, and a large ocean-view terrace perfect for entertaining and watching sunsets over the Pacific. The backyard includes a jacuzzi and ample space for a pool. With its oversized lot, expansive square footage, and panoramic views, this is a rare opportunity to own a premier Manhattan Beach view property minutes from downtown and the beach. Listed at $9,750,000. Represented by Jen Caskey, JenCaskeyGroup.com, Compass Real Estate Manhattan Beach.That's the Elevated Luxury Report — Southern California edition. New episodes weekly. Find us on Apple Podcasts, Pandora, Amazon, Spotify, YouTube, iHeart Google, Apple, and at ElevatedMagazines.com. powered by Timberlane, 30 years crafting the finest shutters, Timberlane.com. This is Elevated. Until next time.

On this episode of the Woodard Report podcast, Joe speaks with Dr. Sabrina Starling about how business owners can reclaim time and increase profitability by focusing on high-value work, empowering their teams, and adopting a "$10,000 hour" mindset. They explore common missteps like failing to delegate, overcomplicating services, and misunderstanding client needs, while emphasizing the importance of human connection in an AI-driven world. The conversation also highlights strategies for hiring A-players and building a business that supports life, not the other way around. About Dr. Sabrina Starling Sabrina Starling, Ph.D., PCC, BCC, The Business Psychologist, is the international bestselling author of How to Hire the Best and The 4 Week Vacation®. Her work has been featured in Forbes, Entrepreneur.com, and Thrive Global. She is the founder of Tap the Potential and cohost of the Profit by Design Podcast, globally ranked in the top 5% of most popular shows by Listen Notes. Listed in The Daily Hustle's Top 50 Entrepreneurs to Watch in 2022, Dr. Sabrina is on a mission to send 10,000 entrepreneurs on a 4 Week Vacation® in 10 years. Discover How To Make Your Time Worth $10,000 An Hour TEDx Talk: From Burnout to Balance: Redefining Success in Work and Life Tap the Potential LLC Connect with Dr. Sabrina on LinkedIn Thank you to our show sponsor, Puzzle! Puzzle is the next generation firm: AI-powered, human-led. Puzzle replaces manual QuickBooks workflows with AI-driven books built for review, approval, and audit-ready accountability. Learn more at Puzzle.io. Learn more about the show and our sponsors at Woodard.com/podcast

President of the Victorian Farmers Federation, Brett Hosking, joined Ross and Russ.See omnystudio.com/listener for privacy information.

In this inaugural episode of the Coinbase Advanced podcast, we break down one of the most confusing macro environments in modern history as crypto sentiment snaps back amid Middle East negotiations. The conversation explores the blurring lines between risk-on and risk-off assets, the systemic security threats posed by Anthropic's new Mythos AI model, and recent DeFi contagion events involving Kelp DAO and Aave. We also dive into the evolution of the "Everything Exchange," examining how the introduction of 24/7 equity perpetuals, commodities trading, and institutional bitcoin accumulation are fundamentally altering the market structure for active traders. (00:00 - 04:38) Coinbase introduces its new monthly series for advanced traders alongside a look at shifting macro sentiment and the SEC's new podcast. (04:38 - 09:07) Scott Melker discusses the breakdown of traditional "risk-off" assets and why current market conditions are the most confusing in history. (09:07 - 15:02) The team analyzes the security risks of Anthropic's Mythos AI model and recent DeFi exploits that highlight the danger of "unknown unknowns" in smart contracts. (15:02 - 17:24) Moheeth breaks down Coinbase Advanced data showing a surge in spot volume and a widening base of unique active traders. (17:24 - 21:07) A deep dive into bitcoin accumulation trends, institutional "strong hands" taking over retail supply, and the significance of whale wallet movements. (21:07 - 31:21) The conversation shifts to the growth of derivatives, including USDC open interest rewards and the transition of Coinbase into a full-stack trading venue. (31:21 - 37:32) Scott and Moheeth explore the disruptive potential of 24/7 equity perpetuals and how 100x leverage on everything will gamify global markets. (37:32 - 41:17) The episode concludes with a look at diversifying trade flows into altcoins and commodities like gold and silver as traders seek an edge in volatile markets. Speakers: David Duong, CFA — Global Head of Investment Research (X: DavidDuong) Moheeth Alvi — Product Lead, Coinbase Advanced (X: @MoheethR) Scott Melker — The Wolf of Wall Street (X: scottmelker)Additional disclaimer:Listed futures and swaps are offered via Coinbase Financial Markets (“CFM”). CFM is a Futures Commission Merchant (FCM) registered with the National Futures Association (NFA), and regulated by the Commodity Futures Trading Commission (CFTC). Our offerings are available only to US residents. Trading in futures and options involves substantial risks. You should only trade in financial products that you are familiar with and understand the associated risks, and after carefully considering whether such trading is suitable in light of your investment experience, financial position, and investment objectives.Please note, not all products, such as equity perpetual contracts would be available to customers in all jurisdictions. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

“These technologies are morally agnostic. They could be the best things ever and the worst things ever, and the determinant is us.” — Jamie Metzl Two summers ago, Jamie Metzl gave a talk on AI and spirituality at the Chautauqua Institution in Upstate New York. That same spot where Salman Rushdie was stabbed on stage a couple of years earlier. Rather than an assassination attempt, Metzl's talk triggered The AI Ten Commandments: A New Moral Code for Humanity — a book co-authored with GPT-5. Metzl humbly claims that AI enabled him to incorporate other non-Christian traditions in a new moral code for humanity. Some might think, however, that this type of ChatGPT-5 co-production reflects a new moral crisis for humanity. The victory of AI slop. Fast information. High on intellectual calories, low on everything else. Five Takeaways •       Co-Authoring with GPT-5: Five to six thousand back-and-forth exchanges over the course of writing the book. Metzl is a novelist who cares deeply about language and the provenance of ideas — he is explicit that this is not the kind of AI fraud that got Mia Ballard's book pulled from Hachette. The analogy he reaches for: Refik Anadol at MoMA, whose installation uses the museum's entire digital collection not to reproduce the images but to create something new from them. The collaboration with AI isn't about outsourcing the thinking. It's about gaining a vantage point that no individual human could have — the same way we collaborate with machines in biology to see the genome, which no one could simply observe by looking at another person. •       Moses's Problem: The biblical 10 commandments, examined closely, don't hold up. The first two are preamble. “Thou shalt not kill” — Moses received it on Sinai and then came down and murdered 3,000 people at God's instruction. The commandments were written by people with no awareness of the moral traditions of the Americas, Asia, or Africa. Metzl's counterproposal uses AI to look at all of human recorded history simultaneously — every tradition, every culture, every spiritual framework — and decipher what they share. The analogy: the Artemis II astronauts seeing Earth holistically from space, rather than one community at a time. •       The Ten Commandments, Listed: (1) Treat every being with compassion and dignity. (2) Do no harm; actively protect the vulnerable. (3) Speak and act truthfully, with integrity and humility. (4) Share generously, especially with those in need. (5) Seek to understand others before judging them. (6) Resolve conflict with fairness, forgiveness, and the intent to heal. (7) Live in harmony with nature and all forms of life. (8) Value wisdom over dominance; cultivate inner growth. (9) Honour the freedom and uniqueness of others. (10) Remember the sacredness of life; live with awe, gratitude, and love. Metzl's favourite is number ten. Andrew's objection: you don't need GPT-5 to come up with any of these. You could get most of them from a local Buddhist centre. •       Humanistic Slop vs. Selfish Survivalism: Andrew's repeated challenge: these principles are so unobjectionable that they amount to nothing — a kind of AI-laundered platitude. Metzl half-concedes, but argues that the absence of articulated universal norms is itself a political danger. Kant described the League of Peace in 1795. It took a hundred and fifty years and two world wars before the UN Charter was signed in 1945. The UN has now largely failed. If we don't articulate what we're trying to achieve, it becomes even harder to get there. Globalism, in Metzl's framing, isn't idealism. It's survivalism. Our fates are intertwined whether we recognise it or not. •       The Eleventh Commandment: World-changing technologies must be governed responsibly, including through national regulation and accountability frameworks. The hope that AI CEOs will voluntarily do the right thing — even the best of them, even Dario, even Demis — is a terrible strategy. It will fail, because some companies will always seek opportunity. The nuclear analogy: at the dawn of the nuclear age, nobody said “alright, just do whatever you want and good luck.” These are civilizational transformations. They require governance. These technologies are morally agnostic. They could be the best things ever and the worst things ever. The determinant is us. About the Guest Jamie Metzl is a technology futurist, geopolitics expert, sci-fi novelist, and founder and chair of OneShared.World. He is a Senior Fellow at the Atlantic Council and a Singularity University expert. He is the author of The AI Ten Commandments: A New Moral Code for Humanity (co-authored with GPT-5, April 21, 2026), Superconvergence, and Hacking Darwin. References: •       The AI Ten Commandments: A New Moral Code for Humanity by Jamie Metzl and GPT-5 (April 21, 2026). •       OneShared.World — Metzl's global social movement and Declaration of Interdependence. •       Episode 2877: Keith Teare on AI Is Not Dangerous — the Silicon Valley seminary argument, one episode prior. •       Episode 2878: Victoria Hetherington on The Friend Machine — the AI intimacy investigation that immediately precedes this show. About Keen On America Nobody asks more awkward questions than the Anglo-American writer and filmmaker Andrew Keen. In Keen On America, Andrew brings his pointed Transatlantic wit to making sense of the United States — hosting daily interviews about the history and future of this now venerable Republic. With nearly 2,900 episodes since the show launched on TechCrunch in 2010, Keen On America is the most prolific intellectual interview show in the history of podcasting. WebsiteSubstackYouTubeApple PodcastsSpotify Chapters: (00:31) - Why GPT-5 and not Claude? The co-author question (02:58) - Is this a joke? The Chautauqua origin story (05:09) - The Refik Anadol distinction: collaboration vs. fraud (07:57) - From the genome to the moral code: why collaborate with AI (08:54) - What is Chautauqua? The six-thousand-person standing ovation (09:53) - Moses's problem: the biblical 10 commandments examined (12:48) - Sam Altman and the Ronan Farrow piece (14:00) - Advanced praise from the Vatican and a leading reform rabbi

Join my online school for eBay sellers here. Get my BOLO books (eBook format) hereGet my BOLO books (printed format) hereContact me for a store review Suzanne@SuzanneAWells.com Follow me on FacebookJoin my private Facebook group here.Find me on YouTube here.Visit my website here.Email your comments, feedback, and constructive criticism to me at Suzanne@SuzanneAWells.com

Skyhooks – Living in the 70s (1974) | 70s Rock Deep DiveWhat if the most important rock album of 1974 never made it out of its home country? In Australia, Skyhooks' debut Living in the 70s was a cultural earthquake — 16 weeks at #1, the highest-selling Australian album of its time, six songs banned from commercial radio, and a bill where AC/DC and Split Ends opened for them. Outside Australia? Complete silence for fifty years.Jason, Tim, and Chip dig into this theatrical, bass-driven, gloriously weird debut from Melbourne's most provocative band — a record that sounds like Alice Cooper, Rocky Horror, Black Oak Arkansas, and a cosmic cowboy walked into a pub and decided to start a glam rock band. It's not what you'd expect from 1974 Australian rock. That's exactly the point.If you love Alice Cooper, Slade, Alex Harvey, early Cheap Trick, or any band that traded guitar heroics for theatrical swagger, this episode is for you.• 0:00 — Intro — This week on Dig Me Out: 70s and 80s rock. Four albums entered the listener poll. One won both — with a tiebreaker. Welcome to Australia.• 1:07 — How the Album Won — The poll breakdown: Detective (1977), Hurriganes' Roadrunner (1974), Thundermug's Thundermug Strikes (1972), and Skyhooks' Living in the 70s (1974). It tied with Detective on the website. It tied with Thundermug on Patreon. Skyhooks won both. Community member Eric Peterson suggested it — then voted against it. Classic.• 3:10 — Australian Correspondent Gavin Weighs In — The band's backstory, straight from someone who actually grew up with this record. Singer Shirley Strachan's wild post-band career (children's television, home renovation hosting, a fatal helicopter crash in 2001). Guitarist Red Simons' 28 years gonging amateurs off stage on Hey Hey It's Saturday. These were not conventional rock band trajectories.• 6:43 — Album History and Chart Context — October 1974, Mushroom Records, produced by Ross Wilson. 16 weeks at #1. Highest-selling Australian album of its time. “Horror Movie” hit #1 on the National Singles Chart in 1975. Listed #9 in 100 Best Australian Albums. Over 475,000 copies and counting. The numbers behind the record that North America never heard.• 11:02 — Community Comments from the Poll — Listener reactions from the Patreon and Discord, including a debate about whether Hurricanes would have been the first Finnish band covered on the show (it wouldn't have been), and the Led Zeppelin/John Bonham drumming-on-a-secret-album conspiracy theory that surrounds the Detective record.• 13:28 — What Works: Jay's Take — The record is nothing like what you'd expect. Bass-driven, not guitar-forward. Theatrical song-as-set-piece writing. A vocalist who sounds — on first listen — like a woman, then like Alice Cooper, then like something you genuinely can't categorize. This album sounds like 70s AM radio in all the ways classic rock nostalgia forgets.• 20:26 — What Works: Chip's Take — Full-face makeup, banned lyrics, and a sound that was aggressively transgressive in conservative 1974 Australia — even if it doesn't register that way in 2026. The theatrical context matters. Watching live performances from the era makes the whole thing click. Think Alex Harvey, early Alice Cooper, pre-MTV showmanship.• 24:00 — “Living in the 70s” and “Whatever Happened to the Revolution” — The title track ages itself but holds up as a hook. Track two is a boogie-groove gut punch that sounds like Dangerous Toys discovered Black Oak Arkansas. If you played this song cold before one of the 80s metal episodes, nobody would have guessed it was from 1974 Australia.• 25:48 — “Carlton (Lygon Street Limbo)” — Hyper-local Melbourne geography meets Caribbean rhythm meets bluesy guitar. Lyrically opaque to anyone who's never been to Carlton, but sonically one of the record's most surprising moments.• 29:54 — The Concert Bill That Rewrites History — At the height of their commercial peak, Skyhooks headlined a show. AC/DC and Split Ends (later Crowded House) opened for them. Three completely different bands, three completely different futures — and Skyhooks had top billing. The footnote that reframes everything.• 31:56 — “Horror Movie” — The Great Disguise — It's not about horror movies. It's about the 6:30 news. The song that became a dancefloor hit by weaponizing social commentary — murders, fires, and violence packaged and broadcast into Australian living rooms every evening. The twist lands. The repetition getting there is a genuine debate.• 38:44 — What Doesn't Work — All three hosts wanted more guitar grit. The record sits in a power-pop middle ground when it could have gone full glam bombast or full distorted rock. Some songs lean too hard on lyrical repetition. “Motorcycle B***h” opens a door it never fully walks through. The hooks are quirky, not cathartic — and for a certain kind of listener, that's a dealbreaker.• 42:12 — “Smut” — The Song That Out-Smutted the 80s — Of everything covered in months of hair metal and 80s sleaze rock, this 1974 Australian track made the hosts blush harder than anything else. An ode to the adult cinema experience in graphic detail. This one got banned from radio. Correctly.• 50:52 — Final Ratings — Jay: EP (“Living in the 70s,” “Whatever Happened to the Revolution,” “Horror Movie,” “You Just Like Me Because I'm Good in Bed,” “Carlton,” “Smut”). Chip: Decent Single (“Living in the 70s,” “Whatever Happened to the Revolution,” “Carlton”). Tim: EP (“Living in the 70s,” “Whatever Happened to the Revolution,” “You Just Like Me Because I'm Good in Bed,” “Carlton,” “Motorcycle B***h”).• 54:47 — Outro and Credits — Thanks to listener Eric Peterson for the suggestion. A reminder that the Aughts are the hottest category in listener voting right now — so if you're submitting a 2000s pick, your odds are slim. For everyone else? The 70s and 80s polls are wide open.

Interview with Steven Sirbovan, President & CEO of ICG Silver & GoldRecording date: 1st April 2026ICG Silver and Gold Corp. is a newly listed exploration company that began trading on the CSE on March 31, 2026, after spinning out from American Pacific Mining. The company holds a single flagship asset, the Tuscarora District, a 10,000-acre contiguous land package in northeastern Nevada positioned at the intersection of the Independence and Carlin Trends. For investors evaluating the junior exploration space, ICG presents a clearly defined near-term catalyst, a funded treasury, and a geological thesis that differentiates it from prior operators at the same project.The Tuscarora District is not a greenfield exploration play. Historical operators Novo Resources and American Pacific Mining conducted 25,000 metres of drilling, collected 5,000 samples, and completed 130 line-kilometres of geophysics across the property. Those programs generated high-grade results, including an intersection of just over 4 metres grading 127 g/t gold at the South Navajo target. Despite this work, the project was consistently treated as a gold-only system. ICG's management believes that interpretation left a significant dimension of the project unexplored: a spatially overlapping, silver-dominant epithermal system, supported by surface rock samples returning up to approximately 38,000 g/t silver at certain targets and near-surface geophysical anomalies.The former Dexter open-pit mine, located just off the property boundary on trend with the South Navajo and Modoc targets, produced approximately 50,000 ounces of gold and 250,000 ounces of silver in the early 1990s and serves as a direct analogue for the style of mineralisation management is targeting.The company enters the market with approximately C$6.2 million in the treasury and a Phase 1 RC drill program of 3,000 to 6,000 metres scheduled to commence in June 2026. RC costs in the region are currently estimated at approximately US$250 per metre, providing ICG with sufficient capital to complete the program without near-term financing pressure. Assay results are expected in August 2026, giving investors a defined newsflow window within the current calendar year.The Phase 1 program targets two categories of drill holes. The first group focuses on South Navajo and Modoc to build toward an eventual mineral resource. The second and more exploration-oriented group targets East Pediment, Grand Prize, King's Vein, and North Navajo areas which are identified through sampling and geophysics but not yet systematically drilled. Hole depths are planned at 200 to 300 metres, consistent with the shallow, open-pittable mineralisation model the company is evaluating.The management team brings relevant capital markets and technical depth. CEO Steven Sirbovan has 13 years of capital markets experience including work at Waterton Global Resource Management with a Nevada focus. The board includes Jeff Swinoga, formerly of Barrick Gold, and Gary Baschuk, who spent significant time at Barrick's Goldstrike operation in Nevada. VP of Exploration Korbon McCall provides direct technical continuity with the project through his prior work with American Pacific.For investors, the near-term thesis is straightforward: a funded drill program, an August 2026 assay window, and a geological interpretation that has not previously been tested at district scale. The key risk, as with any early-stage exploration company, is that drilling results may not confirm the dual-system thesis. Investors should size positions accordingly and monitor Phase 1 results as the primary near-term value inflection point.Learn more: https://cruxinvestor.comSign up for Crux Investor: https://cruxinvestor.com

Matt Weyandt, a client Portfolio Manager on the listed real assets team at Nuveen, discusses how buying "location-specific hard assets" in essential industries that deliver to a "Halo theme" — heavy asset, low obsolescence — creates a buffer against a market that is being driven by headlines and geopolitical risks. Weyandt says that real estate, infrastructure, utilities, midstream energy companies, communications and commodities are not immune to the headlines, but they are built to deliver regardless of market conditions, and he discusses Nuveen's wide range of options for accessing those assets through closed-end funds.

Join us on the latest episode, hosted by Jared S. Taylor!Our Guest: Carrie Hodge, Co-Founder and CEO at Dimer Health.What you'll get out of this episode:Carrie Hodge's experience as both clinician and cancer patient exposed critical gaps in post-discharge care.Dimer Health validated its model through real patient care before scaling technology.The company is introducing a new care model centered on “transitionists” to support recovery at home.AI and clinicians work together to provide continuous, responsive patient support.A $13.5M raise reflects strong product-market fit, patient outcomes, and growing demand.To learn more about:Website https://www.dimerhealth.com/ Linkedin https://www.linkedin.com/company/dimer-health/Our sponsors for this episode are:Sage Growth Partners https://www.sage-growth.com/Quantum Health https://www.quantum-health.com/Show and Host's Socials:Slice of HealthcareLinkedIn: https://www.linkedin.com/company/sliceofhealthcare/Jared S TaylorLinkedIn: https://www.linkedin.com/in/jaredstaylor/WHAT IS SLICE OF HEALTHCARE?The go-to site for digital health executive/provider interviews, technology updates, and industry news. Listed to in 65+ countries.

A forestry group wants the industry to be listed as critical in the government's national fuel plan, saying it's crucial to regional economies and supports other key sectors. Forest Owners Association Chief Executive Elizabeth Heeg spoke to Corin Dann.

-For example: Iowa's reason to root for them is “Ben McCollum simply wins.” Illinois' reason to root for them was ‘elitedepth'…Houston was ‘redemption story'….Duke was ‘best NBA prospect'…St. John's was ‘gritty defense'…-Nebraska's was obviously ‘first time in the Sweet 16'…you wonder if fans across the country like to see the Huskers do well…Our Sponsors:* Check out BetterHelp: https://www.betterhelp.com* Check out Progressive: https://progressive.comAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Join us on the latest episode, hosted by Jared S. Taylor!Our Guest: Matt Seefeld, Chief Executive Officer at MedEvolve.What you'll get out of this episode:Matt Seefeld argues that healthcare's biggest revenue cycle problem is not just strategy, but the lack of visibility into human touches and workflow breakdowns.He says the industry is relying on outdated lagging metrics instead of leading indicators that show where margin is leaking in real time.Seefeld challenges the promise of AI in healthcare, saying automation without financial outcome tracking is incomplete.He identifies wasted touches, front-end errors, and overstaffing as major sources of preventable revenue loss.He believes better revenue cycle performance ultimately improves the patient experience by reducing billing confusion and friction.To learn more about:Website https://medevolve.com/ Linkedin https://www.linkedin.com/company/medevolve/Our sponsors for this episode are:Sage Growth Partners https://www.sage-growth.com/Quantum Health https://www.quantum-health.com/Show and Host's Socials:Slice of HealthcareLinkedIn: https://www.linkedin.com/company/sliceofhealthcare/Jared S TaylorLinkedIn: https://www.linkedin.com/in/jaredstaylor/WHAT IS SLICE OF HEALTHCARE?The go-to site for digital health executive/provider interviews, technology updates, and industry news. Listed to in 65+ countries.

Nick Caserios strange interview  process Rockets Playoff outlook  Lucca leading in points-per-game  Ryan Clark promotes his own Agents clients  Dan Orlovsky: Ty Simpson or Fernando Mendoza?

You don't have an inventory problem… you have a listing problem.If you're constantly thrifting but not seeing sales, your money might be sitting in a death pile of unlisted items. In this episode of Consignment Chats, we break down how to list faster, stop over-sourcing, and actually turn your inventory into profit.Perfect for resellers on eBay, Poshmark, Mercari, and beyond who want to increase sales without buying more.

Tier listing the 2026 NBA rookie class based on long term potential after 1 season! #nba   Check out the TD3 merch: https://the-deep-3-shop.fourthwall.com/   Listen on Spotify!: https://open.spotify.com/show/3elbbqVumwqz8wlIdknsLW   Listen on Apple Podcasts!: https://podcasts.apple.com/us/podcast/the-deep-3-podcast/id1657940794   Follow us on TikTok!: https://www.tiktok.com/@thedeepthree   Follow us on Instagram!: https://www.instagram.com/thedeep3podcast/   Isaac's twitter: https://twitter.com/byisaacg   Mo's twitter: https://twitter.com/Mojo99_   Donnavan's twitter: https://twitter.com/Dsmoot3D   0:00- Intro 1:57- Rookies tier list 1:36:04- Producer Corner 1:52:45- tiktok time Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Join us on the latest episode, hosted by Jared S. Taylor!Our Guest:  Karthik Ganesh, Chief Executive Officer at OnMed.What you'll get out of this episode:Karthik Ganesh describes healthcare as both his profession and his vehicle for making the world better.His 26-year career spans health plans, PBMs, value-based care, consulting, and tech-enabled care delivery.At OnMed, he focused on amplifying product strengths while neutralizing blind spots rather than reinventing what already worked.He believes AI should empower clinicians and improve workflows, while the human element remains the last mile in care.OnMed's work in underserved communities is showing strong adoption, with many patients identifying the care station as their medical home.To learn more about:Website https://www.onmed.com/ Linkedin https://www.linkedin.com/company/onmedcarestation/Our sponsors for this episode are:Sage Growth Partners https://www.sage-growth.com/Quantum Health https://www.quantum-health.com/Show and Host's Socials:Slice of HealthcareLinkedIn: https://www.linkedin.com/company/sliceofhealthcare/Jared S TaylorLinkedIn: https://www.linkedin.com/in/jaredstaylor/WHAT IS SLICE OF HEALTHCARE?The go-to site for digital health executive/provider interviews, technology updates, and industry news. Listed to in 65+ countries.

Pisces:  The Mystical One. This Moon brings imagination and deep dreaming  into awareness. Pisces symbolism: Two fish swimming in opposite directions represent the “higher cosmic realm and earth's grounded connection”.  Where in your starchart do things need to be resolved or dissolved?This is the sign that deals with honoring one's inner feelings.Trusting self is the essential key to the empowerment offered with this New Moon.Mystical and magicalPsychic and intuitiveAbility to manifest and createPisces as a mutable sign is about trusting the flow of life, and that everything is happening in its right time.With a New Moon in Pisces, the guiding and rulership through Neptune calls forth inner movement, and a need for personal freedom, no matter the cost.Neptune is the planet of dissolution when not operating from its spiritual frequency.  In its shadow side Neptune represents the illusions and delusions that can cloud the inner awareness and soul connection.In the sign of Pisces, the dualistic nature requires awareness that everything is connected to everything else. “Unity in all things” is the hallmark for this sign.    Neptune when received through its higher essence opens a direct path to spiritual alignment with the Universe. Some Neptune/Pisces Keys:How can the magical, imaginative, creative, spiritually lead self begin to swim in the clear, crystalline waters of self awareness and inner self knowing?Even though it is difficult, wherever the Pisces energy resides in your chart is where  it's necessary to face self sabotaging emotions.   It's time to get clear away the "who, when and where" you are not valued and supported.Listed are some of the non- viable emotions which need to be recognized, so that better choices of self acknowledgement and self-love can be chosen.FearDoubtBlameShameExceptionResentmentGuiltVictimhood/learned helplessnesslack of confidenceundermining self-talknot feeling good enough______________________Over the next 30 Days  visualize/feel/see one big change you are choosing to make.  Accept yourself for exactly who you truly are and   “Celebrate with Your Inner Wise Muse”. Let's have an Astrology Conversation.  I look forward to seeing you.  Now is the time.https://www.soulsoundinsights.com/light-reading.htmlhttps://www.soulsoundinsights.com/music-musings-meditation.htmlI am proud to announce my new offering as a Certified Creative Depth Coach.  As a Creative Depth Coach, I provide guidance, support and soul insights on how to discover, explore and navigate your life by  recognizing your magnificent "Creative Genius". Some of my modalities and Soul tools are "Art as Process" EFT Tapping,  Sound and Music for Inner Journeying , using the wisdom of Astrology, Tarot, Oracle and Numerology. l   Enjoy Full Moon Lunar Eclipse in Taurus Drumming Video:https://vimeo.com/769123538/b344b2b541"Calling the Wild" or " QuickSilver and Astro Magic" Original Music by MaeRuth McCants 

In this episode, Jon Dwoskin and Craig Zucker discuss the crucial role of proactive legal planning in business. Craig shares how many entrepreneurs skip formalizing agreements early on, leading to preventable conflicts. He stresses the importance of proper documentation and preparing for worst-case scenarios, even in trusted partnerships. Craig Zucker is a shareholder and member of Maddin Hauser's Executive Committee. H co-chairs the firm's Bankruptcy, Restructuring and Debtor-Creditor Rights group. Craig concentrates his practice in bankruptcy and complex insolvency-related matters, serving clients throughout the United States including in New York, Ohio, and Florida. He has a broad range of experience representing debtors and creditors in federal, bankruptcy, and state court proceedings and through out-of-court workouts, mediations, and facilitations. Craig has successfully represented the interests of multi-employer fringe benefit funds, pension funds, health and welfare funds, unions, and retirees in various federal and bankruptcy court proceedings, including Chapters 7, 9, and 11 bankruptcies. He also has gained extensive experience with construction law and construction-related lien and bond rights in federal and state court matters. Craig is AV rated in Martindale Hubbell and has been named in the Best Lawyers in America since 2010. Listed as a Top Lawyer by DBusiness Magazine in litigation-bankruptcy, he also has been recognized as a Michigan Leading Lawyer in the areas of Bankruptcy & Workout Law: Commercial and Creditor's Rights/Commercial Collections Law. Craig was selected by Michigan Lawyers Weekly for induction in their "Hall of Fame" 2023 class, an honor awarded to Michigan legal leaders for their successful careers and valuable contributions to the profession and community. As a presenter at various national and local seminars, Craig shares his extensive knowledge on insolvency, bankruptcy, and debtor/creditor rights.   Connect with Jon Dwoskin: Twitter: @jdwoskin Facebook: https://www.facebook.com/jonathan.dwoskin Instagram: https://www.instagram.com/thejondwoskinexperience/ Website: https://jondwoskin.com/LinkedIn: https://www.linkedin.com/in/jondwoskin/ Email: jon@jondwoskin.com Get Jon's Book: The Think Big Movement: Grow your business big. Very Big!   Connect with Craig Zucker:Website: https://maddinhauser.com/ LinkedIn: https://www.linkedin.com/in/craig-zucker-444447220/ Facebook: https://www.facebook.com/MaddinHauser X: https://twitter.com/MaddinHauserPC Firm LinkedIn: https://www.linkedin.com/company/maddin-hauser-roth-and-heller-pc/ YouTube: https://www.youtube.com/@maddinhauserlaw                                                                                     *E – explicit language may be used in this podcast.

Why would they put that on a Warning Label

The prosecution's motive case against Kouri Richins is built in dollars and bank statements. Forensic accountant Brooke Karrington testified that by March 2022, Kouri carried $7.5 million in debt, was hemorrhaging $80,000 monthly in payments, and owed four payday lenders $2,100 every single day. Her business account was "perpetually in the hole." December 2021 alone saw 77 overdraft transactions.One day after Eric Richins died, Kouri purchased a $2.9 million Midway mansion. Listed it seven days later. It foreclosed. The $1.35 million from Eric's life insurance policies? Gone within three months. By September 2022, she allegedly had $800 left.But the defense hasn't called a single witness yet—and they may have already established reasonable doubt.Through cross-examination, defense attorneys exposed what they argue is an outcome-driven investigation. Dr. Erik Christensen admitted tests that could have determined whether Eric was a long-term fentanyl user—urine, eye fluid, liver tissue, hair follicles—were never performed. He conceded hair follicle results would have factored into his manner-of-death determination.Carmen Lauber spent hours under cross-examination. She admitted testing positive for methamphetamine during the relevant period, changing her story after receiving immunity from three jurisdictions, and being told by a detective that "the goal is to convict Kouri for aggravated murder."Crime scene technician Chelsea Gipson acknowledged the kitchen and basement were never searched the night Eric died. The Moscow Mule copperware was never tested. An empty hydrocodone bottle in Eric's nightstand was never analyzed.Defense attorney Bob Motta analyzes whether the defense has peaked too early—or if their 35 waiting witnesses will finish what cross-examination started.Kouri Richins is presumed innocent until proven guilty.Join Our SubStack For AD-FREE ADVANCE EPISODES & EXTRAS!: https://hiddenkillers.substack.com/Want to comment and watch this podcast as a video? Check out our YouTube Channel. https://www.youtube.com/channel/UC8-vxmbhTxxG10sO1izODJg?sub_confirmation=1Instagram https://www.instagram.com/hiddenkillerspod/Facebook https://www.facebook.com/hiddenkillerspod/Tik-Tok https://www.tiktok.com/@hiddenkillerspodX Twitter https://x.com/TrueCrimePodThis publication contains commentary and opinion based on publicly available information. All individuals are presumed innocent until proven guilty in a court of law. Nothing published here should be taken as a statement of fact, health or legal advice.#KouriRichinsTrial #EricRichinsMurder #ForensicAccountingEvidence #CarmenLauber #ReasonableDoubt #DefenseStrategy #UtahTrial #InvestigationGaps #BobMotta #HiddenKillersPod

(1) Rob Dauster, Field of 68, listed potential Penny Hardaway replacements (2) What's next for Kirk Cousins, the Broncos, and a look around the NFL

Jones and Keefe react to news that Jayson Tatum has been listed as questionable for tomorrow game against the Dallas Mavericks and question if this is the game where he makes his return.

Sign up for a $1 per month trial period at https://shopify.com/sloan Let's get into it! We talk #selenagomez #arianagrande and WAY more! Learn more about your ad choices. Visit megaphone.fm/adchoices