Podcasts about experimental medicine

Nous savons tous que mal dormir nous rend fatigués, irritables, moins concentrés. Mais les effets du manque de sommeil vont bien au-delà : il perturbe en profondeur notre système immunitaire. En clair, moins vous dormez, plus vous tombez malade.Le lien entre sommeil et immunité est aujourd'hui solidement établi par la science. Une étude emblématique menée en 2009 par le Dr Aric Prather, chercheur à l'Université de Californie à San Francisco, l'a prouvé de façon spectaculaire. L'équipe a suivi 164 volontaires en bonne santé, dont elle a surveillé la durée de sommeil pendant une semaine. Ensuite, ces personnes ont été délibérément exposées au virus du rhume. Résultat ? Ceux qui dormaient moins de 6 heures par nuit étaient quatre fois plus susceptibles d'attraper le virus que ceux qui dormaient plus de 7 heures. Et ce, indépendamment de leur âge, de leur poids, ou de leurs habitudes de vie.Mais pourquoi ce lien aussi fort ? Le sommeil joue un rôle clé dans la régulation des cytokines, ces protéines qui orchestrent les réponses immunitaires. Certaines cytokines sont pro-inflammatoires (elles déclenchent la réponse face à un pathogène), d'autres sont anti-inflammatoires (elles apaisent le système une fois le danger passé). Le manque de sommeil déséquilibre cette régulation : il réduit la production de cytokines protectrices et augmente l'inflammation chronique, ce qui affaiblit la réponse face aux infections.Autre impact majeur : le sommeil influence directement l'activité des lymphocytes T, ces cellules immunitaires chargées de repérer et de détruire les cellules infectées. Des travaux publiés en 2019 dans Journal of Experimental Medicine ont montré que pendant le sommeil, les récepteurs d'adhésion des lymphocytes T sont plus actifs, ce qui leur permet de mieux se fixer aux cellules infectées. En privant l'organisme de sommeil, on réduit donc son efficacité à combattre les virus.Enfin, la privation chronique de sommeil dérègle aussi la production de mélatonine (hormone du sommeil), qui joue un rôle indirect mais réel dans la modulation immunitaire. Résultat : un organisme fatigué devient un terrain vulnérable aux maladies, aux infections, et même à certaines inflammations chroniques.En résumé, bien dormir n'est pas un luxe, c'est une stratégie de défense naturelle. Le sommeil renforce nos défenses, répare notre corps, et garde notre système immunitaire en alerte. Veiller trop tard, accumuler les nuits courtes ou sacrifier son repos a donc un prix… parfois payé en jours de fièvre ou en rhumes à répétition. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Guest Kristy Red-Horse is a biologist who specializes in coronary artery development and disease. She says the latest advances in treatment of blockages could do away with invasive bypass surgeries in favor of growing new arteries using molecules like CXCL12, known to promote artery regrowth in mice. Red-Horse explains how leaps forward in medical imaging, expanding atlases of gene expressions, and new drug delivery mechanisms could someday lead to trials in humans. But, before that day can arrive, much work remains, as Red-Horse tells host Russ Altman in this episode of Stanford Engineering's The Future of Everything podcast.Have a question for Russ? Send it our way in writing or via voice memo, and it might be featured on an upcoming episode. Please introduce yourself, let us know where you're listening from, and share your quest. You can send questions to thefutureofeverything@stanford.edu.Episode Reference Links:Stanford Profile: Kristy Red-HorseKristy's Lab: Red-Horse LabConnect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>> Twitter/X / Instagram / LinkedIn / FacebookChapters:(00:00:00) IntroductionRuss Altman introduces Kristy Red-Horse, a professor of biology at Stanford University.(00:03:46) Replacing Open-Heart SurgeryWhy bypass surgery is invasive, risky, and requires long recovery.(00:05:09) Challenges in Artery GrowthThe difficulty of targeting artery growth with medical interventions.(00:07:32) The Role of Collateral ArteriesDefinition and function of collateral arteries as natural bypass.(00:09:37) Triggers for Natural Bypass FormationGenetic factors that may influence the growth of these bypass arteries.(00:10:49) Unique Properties of Coronary ArteriesChallenges of ensuring artificial growth replicates natural artery function.(00:13:04) The Discovery of CXCL12A key molecule that stimulates collateral artery formation.(00:16:16) Precise Artery Growth ControlThe results of targeted CXCL12 injections into mice hearts.(00:17:32) CXCL12's Overlooked RoleThe molecule's role in the immune system and stem cells.(00:20:27) Guinea Pigs and Heart Attack ResistanceHow guinea pigs naturally develop collaterals.(00:23:19) Preventing Heart DiseaseUsing artery growth treatments to target early-stage coronary disease.(00:25:25) Breakthroughs in Imaging TechnologyNew technology that enables identification of collateral growth pathways.(00:27:07) How Collateral Arteries FormThe two mechanisms in which new arteries form.(00:28:48) The Future of Medical Artery GrowthThe possibility of eliminating bypass surgery with targeted artery growth. Connect With Us:Episode Transcripts >>> The Future of Everything WebsiteConnect with Russ >>> Threads / Bluesky / MastodonConnect with School of Engineering >>>Twitter/X / Instagram / LinkedIn / Facebook

In her book, Rumbles, medical historian Elsa Richardson explores the history of the human gut. She talks with Steve about dubious medical practices, gruesome tales of survival, and the things that medieval doctors may have gotten right. SOURCE:Elsa Richardson, medical historian at the University of Strathclyde. RESOURCES:Rumbles: A Curious History of the Gut: The Secret Story of the Body's Most Fascinating Organ, by Elsa Richardson (2024).Michael Levitt retirement speech (2024)."Was There Really a Hawthorne Effect at the Hawthorne Plant? An Analysis of the Original Illumination Experiments," by Steven D. Levitt and John A. List (NBER Working Paper, 2009)."Floating Stools — Flatus versus Fat," by Michael D. Levitt and William C. Duane (The New England Journal of Medicine, 1972)."Factors Influencing Pulmonary Methane Excretion in Man," by John H. Bond, Rolf R. Engel, and Michael D. Levitt (Journal of Experimental Medicine, 1971).The Expression of the Emotions in Man and Animals, by Charles Darwin (1872).The Levitt Lab Founding School Leader, job listing.The Levitt Lab, information page. EXTRAS:"An Update on the Khan World School," by People I (Mostly) Admire (2023).“Is This the Future of High School?” by People I (Mostly) Admire (2022).“Sal Khan: ‘If It Works for 15 Cousins, It Could Work for a Billion People,'” by People I (Mostly) Admire (2021)."The Power of Poop," by Freakonomics Radio (2011).

Join the Parajunkie Fam! We have BIG stuff coming up:) www.patreon.com/savannahunderground Use code 50OFF to get 50% off your first month! Eligible through Dec 24th! In this gripping episode of The Most Haunted City on Earth, we delve into the enigmatic world of Kozyrev Mirrors, cylindrical spirals of aluminum designed to neutralize electromagnetic interference and foster profound states of consciousness. Created based on the pioneering theories of Russian scientist Nikolai Kozyrev, these mirrors are said to create torsion fields that heal, enhance intuition, and potentially manipulate time itself. Experiments from the Institute of Experimental Medicine in Siberia have shown individuals achieving remote viewing and psychic phenomena, suggesting a breach into the fabric of time. Despite robust skepticism and claims of pseudoscience from the scientific community, the tales from within these mirrors—ranging from transcendent experiences to profound psychological impacts—paint a picture of human potential and consciousness that challenges our understanding of reality. Join us as we explore the history, experiences, and controversies surrounding these mystical constructs that promise to unlock the mysteries of time and consciousness. --- Support this podcast: https://podcasters.spotify.com/pod/show/john-taylor-timmons/support

Le pouvoir des odeurs dans le cadre de la lutte contre le cancer repose sur les mécanismes des thérapies olfactives qui exploitent les interactions entre les systèmes sensoriels, immunitaires et hormonaux. Bien que l'idée de soigner le cancer uniquement par des odeurs soit ambitieuse et reste à l'état de recherche, des études scientifiques ont démontré que certaines odeurs et molécules odorantes peuvent avoir un impact positif sur l'organisme, notamment en réduisant le stress et en modulant l'activité cellulaire. Une étude notable, publiée dans *Scientific Reports* en 2019, a examiné l'effet des huiles essentielles, comme celles de lavande, de bergamote et de bois de santal, sur la réduction du stress chez les patients atteints de cancer. Le stress chronique est connu pour affaiblir le système immunitaire et aggraver la progression de nombreuses maladies, y compris le cancer. En exposant les patients à ces odeurs, les chercheurs ont observé une diminution des niveaux de cortisol, une hormone du stress, et une amélioration de l'état émotionnel des participants, contribuant potentiellement à une meilleure réponse du système immunitaire. D'autres recherches, comme celles publiées dans *The Journal of Experimental Medicine*, ont étudié l'effet de molécules odorantes spécifiques, comme le limonène, un composé présent dans les agrumes. Une étude réalisée par une équipe de l'Université de l'Arizona a montré que la consommation de limonène peut réduire la taille des tumeurs mammaires chez la souris. Bien que les mécanismes exacts ne soient pas complètement élucidés, il semble que le limonène ait des propriétés anti-inflammatoires et puisse induire l'apoptose, un processus où les cellules cancéreuses s'autodétruisent. De plus, des chercheurs de l'Université de Freiburg ont exploré comment les récepteurs olfactifs, qui ne sont pas uniquement situés dans le nez mais aussi dans les tissus corporels, peuvent influencer le comportement des cellules cancéreuses. Par exemple, l'activation de récepteurs olfactifs dans les cellules du cancer de la prostate a montré un potentiel pour ralentir la croissance tumorale. Ces études mettent en lumière le rôle des odeurs non seulement comme un outil de gestion des symptômes liés au cancer, comme l'anxiété et la douleur, mais aussi comme un moyen potentiel de moduler les processus cellulaires. Cependant, les scientifiques s'accordent à dire que des recherches supplémentaires sont nécessaires pour transformer ces découvertes en thérapies efficaces et fiables. En attendant, les odeurs sont surtout utilisées comme un complément aux traitements traditionnels pour améliorer la qualité de vie des patients. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

In this episode of the Safer Chemicals Podcast, we dive into ECHA's new initiatives in advancing non-animal testing methods through the New Approach Methodologies Framework Contract.Our guests, Sylvia Escher from the Fraunhofer Institute for Toxicology and Experimental Medicine, and Tomasz Sobanski from ECHA's Alternative Methods Team, discuss research projects aimed at transforming how chemicals are assessed for safety.Useful linksECHA to investigate new test method potentially replacing toxicity testing with fish - ECHA news 13 November 2024Animal testing under the REACH Regulation**************Subscribe to our YouTube channelSubscribe to our Safer Chemicals PodcastSubscribe to our newsFollow us on:TwitterFacebookLinkedInVisit our website Disclaimer: Views expressed by interviewees do not necessarily represent the official position of the European Chemicals Agency. All content is up to date at the time of publication.Hosted by Ausha. See ausha.co/privacy-policy for more information.

Stéphan Toupin, a standout in the medical sales industry, unveils his journey from academia to entrepreneurship, offering listeners an insider perspective on navigating career shifts with purpose and passion. Join us as Stéphan, who traded in his lab coat for a sales portfolio, shares his early realization that pursuing a PhD wasn't his calling. He takes us through his rapid rise from a pharmaceutical sales rep to a management position and, ultimately, to establishing his own medical device distributorship. This episode is packed with insights for anyone considering a career shift within medical sales or exploring entrepreneurial ventures. Discover the nuanced transition from pharma to the dynamic world of medical device sales, where understanding complex stakeholder landscapes is crucial. Stéphan sheds light on the challenges and rewards of this sector and how his passion for medical science and innovation fueled his leap into entrepreneurship. He shares strategies for success, including the critical importance of knowing your product and audience and the unique facets of medical device sales compared to pharmaceuticals. Listeners will gain a clearer picture of the financial and personal risks involved in this path and why freedom and self-direction can outweigh monetary gain. Finally, Stéphan offers a masterclass on entering the U.S. market with foreign medical devices, detailing the essential steps companies often overlook. He discusses the importance of reimbursement strategies, understanding CPT codes, and the choice between different types of distributors. With a focus on education and long-term partnerships, Stéphan's approach is both strategic and collaborative. Ending on a note of personal growth and ambition, he shares his vision of empowering his team to ensure the success of his business while pursuing new opportunities, providing a roadmap for aspiring entrepreneurs in the medical sales industry. Meet the guest: Experienced President with a demonstrated history of working in the medical device and pharmaceutical industry. Born and raised in the east part of Canada, French is my first language.  Bachelor's degree in medical biology and Master's in Experimental Medicine. Seventeen years in the pharmaceutical industry as a sales representative, sales manager, government affairs, market access, and training.  Started a medical device distribution in 2012, covering all of Canada. Moved down to the USA in 2015. Partner in 2 other medical device distributions. As he says, "Enjoying life under the sun!"

Peter Openshaw CBE is a respiratory physician and mucosal immunologist at Imperial College London, where he is Professor of Experimental Medicine at the National Heart and Lung Institute. His because a familiar voice in the media during the Covid-19 pandemic. We discuss how his clinical and research interests intertwine, and how his Quaker principles underpin his approach to clinical practice and experimental work. https://profiles.imperial.ac.uk/p.openshaw  

En el episodio de hoy os explico por qué realizo cada mañana desde hace años una caminata en ayunas antes de empezar el día. Además desgrano los beneficios que tiene para nuestra salud. Estudios utilizados: Mitsui, T., Shimaoka, K., Tsuzuku, S., Kajioka, T., & Sakakibara, H. (2008). Gentle exercise of 40 minutes with dietary counseling is effective in treating metabolic syndrome. The Tohoku Journal of Experimental Medicine, 215(4), 355-361. https://www.jstage.jst.go.jp/article/tjem/215/4/215_4_355/_article Harun, I., Briawan, D., Riyadi, H., & Khomsan, A. (2022). Effects of walking exercise program based on duration on the body composition and lipid profile in overweight and obesity female college students. Current Research in Nutrition and Food Science Journal. https://www.foodandnutritionjournal.org/volume10number3/effects-of-walking-exercise-program-based-on-duration-on-the-body-composition-and-lipid-profile-in-overweight-and-obesity-female-college-students/ Reichelt, M., Yanni, L., Wygand, J., Petrizzo, J., & Otto, R. (2019). The role of acute fasting on substrate utilization during submaximal exercise. https://journals.lww.com/acsm-msse/fulltext/2019/06001/the_role_of_acute_fasting_on_substrate_utilization.1148.aspx Walker, K., Piers, L., Putt, R., Jones, J. A., & O'dea, K. (1999). Effects of regular walking on cardiovascular risk factors and body composition in normoglycemic women and women with type 2 diabetes. Diabetes Care, 22(4), 555-561. https://diabetesjournals.org/care/article/22/4/555/19147/Effects-of-regular-walking-on-cardiovascular-risk —————ENTRENAMIENTOS PERSONALIZADOS———— Si quieres entrenar conmigo, escríbeme a: pablo@pablojcastillo.es Y estaré encantado de atenderte. ————DESCUENTOS PARA VOSOTROS:—————— - NUTRICIÓN DE NÄAK Probar los productos de NÄAK: https://bit.ly/3Pvn2OS - RELOJES COROS Para cualquier COROS, tienes un 5% de descuento con mi código: PCASTILLO en la web oficial: https://bit.ly/3z4L6QI - AIROFIT Si os interesa y queréis haceros con uno, os dejo esté link a la web oficial con un 15% de descuento: https://bit.ly/42NcDTe - Minimalism Brand. Compra la ropa de la empresa ética Minimalism. https://minimalismbrand.com/?ref=Pcastillo - IDOVEN, CARDIOLOGÍA DEPORTIVA Os dejo también el enlace de DESCUENTO que ha preparado IDOVEN para vosotros. 10% de descuento para los estudios de 7 días y de 21 días. Aprovechad si os interesa. https://idoven.ai/discount/PABLOCASTILLO10 - NUTRITRAIN LIFE Tenéis descuento en todos los tratamientos tanto Online como presenciales, si es presencial, sólo tenéis que decir que vais de nuestra parte. https://nutritrainlife.com Si es online, podeis usar el código: PABLOCASTILLO10 - GAFAS SALICE En la web de las gafas de origen italiano SALICE, con mi código SALICE10, tenéis un 10% de descuento. https://salice.es -----------ESCUCHA NUESTROS PODCAST----------- - IVOOX: http://www.ivoox.com/s_p2_580231_1.html - APPLE PODCAST: https://itunes.apple.com/es/podcast/neorider-trail-running-livetalks/id1392977771?mt=2 -SPOTIFY https://open.spotify.com/show/1wYUabeCzBT33CHkNnrKyg?si=013f0ae69a7f48b7 ------------SIGUE A PABLO----------- Email: info@pablojcastillo.es Facebook: https://www.facebook.com/PabloJ.CastilloPerez Strava: https://www.strava.com/athletes/7774094 Instagram: https://www.instagram.com/pablocastillogr Twitter: https://twitter.com/PabloCastilloGr

En el episodio de hoy os explico por qué realizo cada mañana desde hace años una caminata en ayunas antes de empezar el día. Además desgrano los beneficios que tiene para nuestra salud. Estudios utilizados: Mitsui, T., Shimaoka, K., Tsuzuku, S., Kajioka, T., & Sakakibara, H. (2008). Gentle exercise of 40 minutes with dietary counseling is effective in treating metabolic syndrome. The Tohoku Journal of Experimental Medicine, 215(4), 355-361. https://www.jstage.jst.go.jp/article/tjem/215/4/215_4_355/_article Harun, I., Briawan, D., Riyadi, H., & Khomsan, A. (2022). Effects of walking exercise program based on duration on the body composition and lipid profile in overweight and obesity female college students. Current Research in Nutrition and Food Science Journal. https://www.foodandnutritionjournal.org/volume10number3/effects-of-walking-exercise-program-based-on-duration-on-the-body-composition-and-lipid-profile-in-overweight-and-obesity-female-college-students/ Reichelt, M., Yanni, L., Wygand, J., Petrizzo, J., & Otto, R. (2019). The role of acute fasting on substrate utilization during submaximal exercise. https://journals.lww.com/acsm-msse/fulltext/2019/06001/the_role_of_acute_fasting_on_substrate_utilization.1148.aspx Walker, K., Piers, L., Putt, R., Jones, J. A., & O'dea, K. (1999). Effects of regular walking on cardiovascular risk factors and body composition in normoglycemic women and women with type 2 diabetes. Diabetes Care, 22(4), 555-561. https://diabetesjournals.org/care/article/22/4/555/19147/Effects-of-regular-walking-on-cardiovascular-risk —————ENTRENAMIENTOS PERSONALIZADOS———— Si quieres entrenar conmigo, escríbeme a: pablo@pablojcastillo.es Y estaré encantado de atenderte. ————DESCUENTOS PARA VOSOTROS:—————— - NUTRICIÓN DE NÄAK Probar los productos de NÄAK: https://bit.ly/3Pvn2OS - RELOJES COROS Para cualquier COROS, tienes un 5% de descuento con mi código: PCASTILLO en la web oficial: https://bit.ly/3z4L6QI - AIROFIT Si os interesa y queréis haceros con uno, os dejo esté link a la web oficial con un 15% de descuento: https://bit.ly/42NcDTe - Minimalism Brand. Compra la ropa de la empresa ética Minimalism. https://minimalismbrand.com/?ref=Pcastillo - IDOVEN, CARDIOLOGÍA DEPORTIVA Os dejo también el enlace de DESCUENTO que ha preparado IDOVEN para vosotros. 10% de descuento para los estudios de 7 días y de 21 días. Aprovechad si os interesa. https://idoven.ai/discount/PABLOCASTILLO10 - NUTRITRAIN LIFE Tenéis descuento en todos los tratamientos tanto Online como presenciales, si es presencial, sólo tenéis que decir que vais de nuestra parte. https://nutritrainlife.com Si es online, podeis usar el código: PABLOCASTILLO10 - GAFAS SALICE En la web de las gafas de origen italiano SALICE, con mi código SALICE10, tenéis un 10% de descuento. https://salice.es -----------ESCUCHA NUESTROS PODCAST----------- - IVOOX: http://www.ivoox.com/s_p2_580231_1.html - APPLE PODCAST: https://itunes.apple.com/es/podcast/neorider-trail-running-livetalks/id1392977771?mt=2 -SPOTIFY https://open.spotify.com/show/1wYUabeCzBT33CHkNnrKyg?si=013f0ae69a7f48b7 ------------SIGUE A PABLO----------- Email: info@pablojcastillo.es Facebook: https://www.facebook.com/PabloJ.CastilloPerez Strava: https://www.strava.com/athletes/7774094 Instagram: https://www.instagram.com/pablocastillogr Twitter: https://twitter.com/PabloCastilloGr

Recorded exclusively at this year's Evidence Based Perioperative Medicine (EBPOM) World Congress in London this piece looks in detail at High-Intensity Interval Training (HIIT). HIIT can significantly enhance physical fitness and resilience in cancer patients, reducing complications and improving quality of life. Hear how HIIT can positively impact mitochondrial performance, thus improving cardio-respiratory fitness. The discussion also explores the integration of experimental medicine from bench to bedside, emphasizing the multidisciplinary approach involving surgeons, scientists, and anesthetists. Presented by Andy Cumpstey and Joff Lacey with their guests Colleen Dean, Lecturer in Muscle Cell Biology and Malcolm West, Associate Professor in Colorectal Surgery and Prehabilitation Medicine at the University of Southampton, an honorary appointment as a consultant colorectal and complex cancer surgeon at University Hospitals Southampton NHS Foundation Trust.

Join Athena Bratopoulou as she interviews Dr Zsófia László about her research on Amyotrophic Lateral Sclerosis (ALS) / Motor Neuron Disease (MND) Athena Bratopoulou, an undergraduate Neuroscience student at the University of Dundee, interviews Dr Zsófia László, an MNDA Junior Fellow. They discuss Dr László's journey into the field of Motor Neuron Disease (MND) research, her work on synaptic connections, and the crucial role of glial cells in neurodegeneration. The conversation highlights the challenges and triumphs of scientific research, the importance of a supportive research environment and the connecting with people living with the disease, and the hope for new treatments for MND. This blog provides a personal and professional glimpse into the lives of researchers dedicated to understanding and combating MND.   Find the original text, and narration here on our website. https://www.dementiaresearcher.nihr.ac.uk/blog-the-quest-to-understand-motor-neuron-disease/ #MND #ALS -- Athena Bratopoulou is currently I am doing an internship in the Henstridge Lab at the School of Medicine, University of Dundee, which is centred around synaptoneurosomes in health and in ALS. Athena moved from Greece with her heart set on studying the brain, with a firm belief that it is the single most fascinating thing! Dr Zsofia Laszlo from the School of Medicine, University of Dundee and Euan MacDonald Centre. Zsofia moved to Scotland in October 2020, after finishing her PhD at the Institute of Experimental Medicine in Budapest, Hungary. She joined the laboratory of Euan MacDonald Centre member Dr Chris Henstridge to investigate the mechanisms behind the loss of connection (synapses) between brain cells in MND. -- Enjoy listening and reading our blogs? We're always on the look out for new contributors, drop us a line and share your own research and careers advice dementiaresearcher@ucl.ac.uk This podcast is brought to you in association with Alzheimer's Association, Alzheimer's Research UK, Alzheimer's Society and Race Against Dementia, who we thank for their ongoing support. -- Follow us on Social Media: https://www.instagram.com/dementia_researcher/ https://www.facebook.com/Dementia.Researcher/ https://twitter.com/demrescommunity https://www.linkedin.com/company/dementia-researcher

Dr. Mitchell joined the University of Florida in 2015 as a Preeminence Professor of Neuroscience in the Department of Physical Therapy and McKnight Brain Institute. He founded and directs the UF Center for Breathing Research and Therapeutics (BREATHE) and the NIH-funded graduate and postdoctoral training program of the same name. A major focus of BREATHE is to understand and treat impaired breathing and airway defense (swallowing/cough) caused by neuromuscular injury or disease. Dr. Mitchell also serves as Deputy Director of the UF McKnight Brain Institute. For the past three decades, Dr. Mitchell pioneered studies of neuroplasticity in the neural system controlling breathing. Areas of active investigation include: intracellular and intercellular mechanisms of long-lasting respiratory motor plasticity triggered by repeated exposure to brief episodes of low oxygen (intermittent hypoxia), the ability to harness that intermittent hypoxia-induced spinal plasticity to treat respiratory and non-respiratory paralysis following spinal injury and during motor neuron disease (ALS), cell-based strategies to treat breathing deficits, and the impact of systemic inflammation on breathing and its control. Investigations span intracellular, intercellular and physiological systems level mechanisms, and translation to humans with acquired or neurodegenerative neurological disorders (SCI and ALS). Dr. Mitchell grew up in California where he received his B.S. (Biological Sciences) and PhD (Developmental and Cell Biology) degrees from the University of California at Irvine. After two years of post-doctoral training at the Max Planck Institute for Experimental Medicine in Goettingen, Germany, he moved to the University of Wisconsin-Madison. After one year as a postdoc, Dr. Mitchell became an Assistant Professor in 1981, and then the ranks to become Professor and Chair of the Department of Comparative Biosciences (17 years) and director of the NIH funded Respiratory Neurobiology Training Program (14 years). He chose to leave the University of Wisconsin for the opportunity to join the University of Florida and create the BREATHE Center. Dr. Mitchell has been recognized for his research and teaching accomplishments, including a National Institutes of Health MERIT Award, the Norden Distinguished Teacher Award, the Pfizer Research Award on multiple occasions, the Steenbock Professorship for Behavioral and Neural Science, and distinguished lectureships from the Society for Neuroscience (SFN), American Physiological Society (APS), Association of Chairs of Departments of Physiology (ACDP), American Spinal Injury Association (ASIA), and the Oxford Conference for Modeling and the Control of Breathing.

O pesquisador francês Jean-Philippe Girard, diretor de pesquisa do CNRS (Centro Nacional de Pesquisa da França), e sua equipe identificaram uma molécula que atua no processo inflamatório que causa doenças como a rinite alérgica e a asma, por exemplo. Batizada de TL1A, ela é liberada pelo epitélio respiratório alguns minutos após a exposição a uma substância alérgica e integra a família das alarminas. Taíssa Stivanin, da RFILiberadas em grande quantidade, as alarminas podem iniciar a inflamação, estimular a atividade das células imunológicas e desencadear uma série de reações no corpo, como as alergias. O estudo foi publicado em abril na revista científica Journal of Experimental Medicine.“Nas alergias, um dos fatores mais importantes é o meio ambiente, além das substâncias alérgicas presentes nele e no ar que respiramos em ambientes fechados ou do lado de fora. Ao ar livre, o pólen e alguns tipos de fungos são os que provocam mais reações”, explicou o cientista francês à RFI.Um desses fungos é o Alternaria alternata, que está relacionado a crises de alergia e de asma severa, principalmente quando o tempo está úmido, favorecendo sua dispersão no meio ambiente. A alergia respiratória é a quarta doença crônica mais comum no mundo, segundo a OMS (Organização Mundial da Saúde), e deve atingir a metade da população mundial até 2050. Só na França, a estimativa é que 17 milhões de pessoas sejam alérgicas e 4 milhões sofram de asma.Entre 200 e 400 mil desenvolvem a forma severa da doença e podem ter crises graves, que provocam dezenas de mortes no país. Um dos principais objetivos do estudo, segundo Jean-Philippe Girard, foi justamente encontrar um tratamento alternativo para evitar esses óbitos.A equipe do cientista francês estuda há mais de uma década o efeito do fungo alternata no organismo dos alérgicos. Durante a pesquisa, eles perceberam que 15 minutos após o contato com a substância, todas as células que formam o epitélio pulmonar liberaram um sinal de alarme para as defesas do organismo. "Essas alarminas, presentes no tecido, dialogam com nosso sistema imunológico, explica o cientista.“São esses sinais de alarme que chamamos de alarminas. Elas alertam nossas defesas naturais, nesse caso, contra uma substância alérgica. Essas alarminas presentes no pulmão, brônquios e alvéolos pulmonares também avisam quando há um vírus, como o da gripe ou do resfriado”, exemplifica.Alerta para os glóbulos brancosUma das funções da molécula é alertar os glóbulos brancos, presentes nos pulmões, da presença de um corpo estranho. Eles vão, dessa forma, produzir mediadores da reação alérgica, entre eles uma proteína responsável pela produção de muco, que obstruirá os brônquios e causará a inflamação. “Ao bloquearmos as alarminas, que dão início a essa cadeia de reações, reduzimos a inflamação. Se agimos no meio do processo, há outros mecanismos que podem compensar essa ação, mas agindo desde o começo, bloqueamos tudo. Esse é o conceito das alarminas, e é isso que é importante” frisa Jean Philippe Girard.Com a nova descoberta, já são três as alarminas identificadas até agora pela Ciência. Uma delas já havia sido detectada há mais de 20 anos pela equipe do cientista francês e em breve beneficiará pacientes que sofrem de patologias como a BPCO, a doença pulmonar obstrutiva crônica.Segundo ele, os pacientes integram seis estudos de fase 3 conduzidos por grandes laboratórios e recebem anticorpos que bloqueiam a molécula. Os resultados devem ser divulgados em 2025 e, se tudo correr bem, um novo medicamento chegará às prateleiras.O objetivo agora é que a nova alarmina, que acaba de ser identificada, também possa ser testada em larga escala. “Nossa nova descoberta virá reforçar o arsenal terapêutico e as possibilidades de tratamento para os pacientes.”Para isso, é preciso investimento para colocar em práticas os testes clínicos necessários para validar o estudo em humanos e obter um medicamento contra a asma severa. Em seu laboratório, Philippe Girard, continuará suas experiências com outras substâncias alergênicas, como ácaros ou polens, que também estão na origem de alergias graves.

Frank Waldron-Lynch is a globally recognised Physician-Scientist with over two decades of experience in leading research and clinical development in autoimmunity, transplant immunology, and rare diseases across academia, biotech, and pharmaceutical sectors. Frank is a distinguished Consultant Clinician with multi-layer expertise in Immunology, Translational Medicine, Internal Medicine, Endocrinology, and Metabolism. A strategic leader and independent thinker with a proven track record in hiring talent, forming, developing, and mentoring high performing teams that consistently deliver transformative therapies for patients. Most recently, Frank held the position of VP, Cell Therapy, and Immunology Research at Vertex, in Boston, USA. Prior to this Frank held the position of Translational Medicine Expert and Global Inflammasome Lead at Novartis Institutes for Biomedical Research, Basal, Switzerland, and spent several years on faculty at University of Cambridge, where he was a Senior Clinical Trials Fellow in the Division of Experimental Medicine and Therapeutics, as well as being an Honorary Consultant in Endocrinology and Internal Medicine at Addenbrookes Hospital, Cambridge, UK. Dr. Waldron-Lynch, BSc, MA, MB, BChir (Cantab), PhD, FRCP (Lond), FRCPI, trained in academic and clinical medicine at Yale University, University of Cambridge, University College Cork, and University of Galway. He has published numerous scholarly articles in his research areas of interest and holds fellowships from the Royal College of Physicians of the United Kingdom and the Royal College of Physicians of Ireland. Frank (OC 89) is married to Maeve and has two sons who both currently attend Clongowes Wood College. Both his father Derrick (OC 54) and brother Tom (OC 87) also attended Clongowes. In his spare time, he enjoys snowboarding, sailing, and gardening. Frank left Clongowes in 1989 --- Send in a voice message: https://podcasters.spotify.com/pod/show/portraitsofclongowes/message

Organoide sind ein junges Forschungsfeld in der Onkologie, auf dem zahlreiche Hoffnungen ruhen. Doch was sind Organoide und welche Anwendungsfelder könnten sich in der Zukunft ergeben? Darüber sprechen wir in der neuen Episode von O-Ton Onkologie mit Dr. Rene Jackstadt am Beispiel von Darmkrebsorganoiden. Er ist Leiter der Nachwuchsgruppe Tumorprogression und Metastasierung am Deutschen Krebsforschungszentrum, dem DKFZ, in Heidelberg, sowie dem HI-STEM, Heidelberg Institute for Stem Cell Technology and Experimental Medicine. Dr. Jackstadt schildert im Podcast mit Elisa Breuer und Jochen Schlabing, wie Darmkrebsorganoide in Zukunft helfen könnten, eine bessere Präzisionsmedizin durchzuführen: Mit ihrer Hilfe sollen individuell wirksame Therapien ausgewählt werden können. „Darmkrebsorganoide haben uns in den letzten Jahren verholfen, näher an den Patienten zu rücken“, so seine Einschätzung. Außerdem berichtet er, welche grundlegenden Fragen zur Tumorbiologie mithilfe der Organoide an seiner Arbeitsgruppe erforscht werden und welche Grenzen die 3D-Systeme haben. Zum Folgen-Überblick: medical-tribune.de/o-ton-onkologie Weiterführende Informationen: - https://www.hi-stem.de/staff-jackstadt - https://www.dkfz.de/de/tumorprogression-metastasierung/index.php - Medical-tribune.de - Journalonko.de

Flu is the forgotten killer. What new vistas of vaccinology opened up after the COVID-19 pandemic? In what ways can flu treatments change as a consequence of lessons learned?  Listen to this excellent panel of experts, Peter Openshaw,  Respiratory physician and Mucosal Immunologist, Professor of Experimental Medicine, Imperial College, London and ESWI Board Member, Anthony Gordon, Chair in Anaesthesia and Critical Care, NIHR Research Professor and Senior Investigator, Imperial College, London, and Susanne Herold, Professor of Medicine, Infectious Diseases and Pulmonary Research, University Hospital Giessen und Marburg, eloquently converse about what the COVID-19 pandemic taught us and how it can help to improve how we deal with flu; And learn what the architects in the Victorian age got right with regards to prevention!

Hello bug lovers! Today, we're guided by Mike Skvarla into a deep dive on West Nile virus. A mosquito borne illness, West Nile is something the Arthro-Pod crew has learned a lot about over the course of their lives and careers. In fact, one of them even tested positive for it after trying to give blood... Mike was inspired by Episode 1031 of the This Week in Virology podcast, where they discussed a recent paper on the subject. The paper is “Autoantibodies neutralizing type I IFNs underlie West Nile virus encephalitis in ∼40% of patients”, by Gervais et al. published in the Journal of Experimental Medicine. Tune in to learn about the history of WNV and the current research focused on it. The virus of concernQuestions? Comments? Follow the show on Twitter @Arthro_PodshowFollow the hosts on Twitter @bugmanjon, @JodyBugsmeUNL, and @MSkvarla36Get the show through Apple Podcast, Spotify, or your favorite podcatching app!If you can spare a moment, we appreciate when you subscribe to the show on those apps or when you take time to leave a review!Subscribe to our feed on Feedburner!  

Today, Dr. Ezra Schwartz and Dr. Nakia Sarad continue exploring how vascular surgeons and patients communicate. They discuss how we share stories and what may get lost in translation. Dr. Rita Charon is a general internist, professor of medicine, and professor and founding chair of medical humanities at Columbia University. Dr. Charon originated the field of narrative medicine and is the founder and executive director of the Program in Narrative Medicine at Columbia. A literary scholar, Dr. Charon completed a Ph.D. in English at Columbia, concentrating on narratology and the works of American-British author Henry James. She is the author of Narrative Medicine: Honoring the Stories of Illness, co-author of Principles and Practice of Narrative Medicine, and co-editor of Stories Matter: The Role of Narrative in Medical Ethics and Psychoanalysis and Narrative Medicine. Dr. Abraham Fuks is a clinical immunologist, a Professor in the Department of Medicine and Division of Experimental Medicine at McGill University, a Professor of Oncology at the Goodman Cancer Institute, and served as Dean of the McGill University Faculty of Medicine from 1995 to 2006.  Dr. Fuks' has published on the metaphors of medicine and ethics in clinical research. In 2021, Dr. Fuks published a book, The Language of Medicine, in which he explores the ability of language to heal or harm and the potent metaphors prevalent in clinical care, especially military metaphors. Dr. Anahita Dua is a vascular surgeon at the Massachusetts General Hospital, an associate professor of surgery at Harvard Medical School, and a frequent guest on Audible Bleeding.  Resources: Dr. Charon's related works: Narrative Medicine: Honoring the Stories of Illness The Principles and Practice of Narrative Medicine Stories Matter: The Role of Narrative in Medical Ethics and Psychoanalysis and Narrative Medicine TEDx Talk Dr. Fuks' related works: The Language of Medicine The Mindful Medical Learner Podcast featuring Dr. Fuks Arthur Frank, The Wounded Storyteller: Body, Illness, and Ethics  Dr. Dua's related works:  Epidemiology of Peripheral Arterial Disease and Critical Limb Ischemia Peripheral Artery Disease: Where We Are and Where We Are Going Validated QOL surveys and Patient Reported Outcome Measures: PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease: Investigating Trajectories): Overview of Design and Rationale of an International Prospective Peripheral Arterial Disease Study Patient-Reported Outcomes for Peripheral Vascular Interventions for the Vascular Quality Initiative Eric Cassell & Functionality Vasc QOL Questionnaire  PAD QOL Questionnaire Vasc QL-6 Questionnaire European QL 5D 5L Questionnaire X Handles (previously known as Twitter): Dr. Anahita Dua (@AnahitaDua) Dr. Rita Charon (@RitaCharon) Dr. Abraham Fuks (@Abe_McGill) Dr. Ezra Schwartz (@ezraschwartz10) Dr. Nakia Sarad (@NakSaradDO)

CONTÁCTAME POR WHATSAPP https://wa.me/message/VLBJNM7KBBQDC1 DÉJAME CONOCER TU CASO HACIENDO CLIC AQUÍ - https://nelsonarturopsicologo.com/superar-ansiedad Mi página web https://nelsonarturopsicologo.com/ Se estima que alrededor del 15% de la población mundial sufre de Tinnitus o acufenos, en consecuencia, se ha convertido en un caso de investigación importante para la ciencia médica. Si te has preguntado si un medicamento o una terapia cura el tinnitus, desde libre de ansiedad que hemos tratado este tema en el pasado (Te puede interesar: Como Quitar el Tinnitus Causado por la Ansiedad (https://nelsonarturopsicologo.com/como-quitar-tinnitus-ansiedad/)),te presentamos algunos desarrollos científicos para el avance en el tratamiento del Tinnitus. ¿Qué puede tratar o curar el Tinnitus? Este trastorno se presenta cuando una persona siente un sonido o zumbido molesto en sus odios que no proviene de una fuente externa, en relación a esto, desde libre de ansiedad hemos visto formas naturales de curar el Tinnitus (También puede leer: Zumbido, Tinnitus o acúfenos en el oído – ejercicios para quitarlo (https://nelsonarturopsicologo.com/zumbido-tinnitus-o-acufenos-en-el-oido-ejercicios-para-quitarlo/)), especialmente haciendo uso de la terapia cognitivo conductual. Los tratamientos han ido evolucionando mostrando un gran avance en el tratamiento del Tinnitus, tal como se muestra en el video adjunto, varias investigaciones han mostrado resultados impresionantes como la de Dang y Lui ( https://www.sciencedirect.com/science/article/abs/pii/S0165587618304798#preview-section-abstract) que mediante la inyección de Botox en la articulación sinovial tipo bicondílea que existe entre el hueso temporal y la mandíbula, se relaja esa zona y con ello se reduce o se elimina el Tinnitus. Otra investigación interesante establece que los relajantes musculares como el magnesio y el zinc (http://ddigital.umss.edu.bo:8080/jspui/handle/123456789/38137) cura el Tinnitus de manera temporal, del mismo modo, existen propuestas innovadoras como un tratamiento que emplea estimulación eléctrica y el enmascaramiento de los zumbidos (https://pubmed.ncbi.nlm.nih.gov/37266943/) para descansar en núcleo coclear reduciendo la sensibilidad o una inflamación. La psicología como avance en el tratamiento del Tinnitus Se ha evidenciado que gracias a la Terapia cognitivo conductual (https://doi.org/10.1007/978-981-13-6123-4_7) empleando el proceso de la HABITUACIÓN, es decir, acostumbrarse a una situación disminuyendo de forma paulatina y significativa el impacto que tiene en uno mismo, se logra disminuir los efectos de los zumbidos molestos en los oídos, de igual modo ,complementando con ejercicios relajantes se obtiene una forma natural de curar el Tinnitus. Independientemente del método que se opte como cura del Tinnitus, es evidente que las investigaciones de este trastorno avanzan a pasos agigantados y que es probable que pronto se encuentre una cura definitiva. Referencias Bibliográficas (H2) Dang, J., & Liu, Y. C. C. (2019). Treatment of objective tinnitus with transpalatal Botox® injection in a pediatric patient with middle ear myoclonus: A case report. International Journal of Pediatric Otorhinolaryngology, 116, 22-24. Recuperado de https://www.sciencedirect.com/science/article/abs/pii/S0165587618304798#preview-section-abstract Hernández Cordero, M., & Hernández Montero, G. (2020). Tinnitus: diagnóstico, mecanismos fisiopatológicos y tratamiento. Revista Cubana de Otorrinolaringología y Cirugía de Cabeza y Cuello, 4(2). Recuperado de https://revotorrino.sld.cu/index.php/otl/article/view/154 Jones GR, Martel DT, Riffle TL, et al. Reversing Synchronized Brain Circuits Using Targeted Auditory-Somatosensory Stimulation to Treat Phantom Percepts: A Randomized Clinical Trial. JAMA Netw Open. 2023;6(6):e2315914. doi:10.1001/jamanetworkopen.2023.15914 MEJIA JORDAN, S. M. (2023). EFECTIVIDAD DEL EMPLEO DE MAGNESIO QUELADO VERSUS SULFATO DE ZINC EN EL TRATAMIENTO DE PACIENTES CON DIAGNOSTICO DE TINNITUS DE CAUSA NEUROSENSORIAL (Doctoral dissertation, RM OT-01/23;). recuperado de: http://ddigital.umss.edu.bo:8080/jspui/handle/123456789/38137 Tang, D., Li, H., Chen, L. (2019). Advances in Understanding, Diagnosis, and Treatment of Tinnitus. In: Li, H., Chai, R. (eds) Hearing Loss: Mechanisms, Prevention and Cure. Advances in Experimental Medicine and Biology, vol 1130. Springer, Singapore. https://doi.org/10.1007/978-981-13-6123-4_7 TE PUEDE INTERESAR Como Quitar el Tinnitus Causado por la Ansiedad (https://nelsonarturopsicologo.com/como-quitar-tinnitus-ansiedad/) Zumbido, Tinnitus o acúfenos en el oído – ejercicios para quitarlo (https://nelsonarturopsicologo.com/zumbido-tinnitus-o-acufenos-en-el-oido-ejercicios-para-quitarlo)

The seventh episode of the DNA Papers is the central one in this podcast series, not only because it marks the halfway point of the podcast, but also, more so, because the paper discussed is at the center of the history of all twentieth century biology. Written by a trio of microbiologists at the Rockefeller University in New York City, this paper without saying so in actual words, represents the first publication to offer evidence that DNA (though not yet known by that name) is the stuff that makes up genes: Avery, Oswald T., Colin M. MacLeod, and Maclyn McCarty. “Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III.” The Journal of Experimental Medicine 79, no. 2 (1944): 137–58. Joining the discussion of this historic paper are the following expert commentators: Matthew Cobb, University of Manchester Ute Deichmann, Ben-Gurion University of the Negev Geoff Montgomery, Independent Science Writer, New York City Please see https://www.chstm.org/video/144 for additional resources on this topic. Recorded on April 28, 2023.

Peter Tyrer is the Professor of Community Psychiatry in the Centre for Mental Health in the Division of Experimental Medicine. Much of his recent work has been focused around personality disorders. Personality disturbance is very common, not just in psychiatric practice, and this importance has been largely unrecognized as the knowledge around this particular disorder is very poor. Many people feel very strongly about the term personality disorder but it's a term that is misunderstood by almost everyone and needs to go. In this episode, Peter teaches us about the various different types of personality disorders, why they can be tricky to treat and the big question as to whether we are born with our personality or it's shaped over time.Find Peter:https://www.imperial.ac.uk/people/p.tyrerBuy his book on personality disorders: https://amzn.eu/d/9U7Tg7uFollow Hurt to Healing on Instagram:@hurttohealingpodA big thank you our wonderful charity partner Shout. Shout is the UK's first 24/7 mental health text support service so if you're struggling or in need of someone to talk to, please remember to text Shout to 85258. And a massive thank you to The&Partnership for supporting my mission and showing what we can achieve when we come together. To find out more about the work The&Partnership creates, visit theandpartnership.com. Hosted on Acast. See acast.com/privacy for more information.

A new study entitled, “Coenzyme Q10 + alpha lipoic acid for chronic COVID syndrome” has been published in the journal Clinical and Experimental Medicine which found that supplementation with Coenzyme Q10 (CoQ10) and alpha lipoic acid (ALA) may be helpful in Long COVID. COVID-19 can deplete CoQ10 levels and damage the mitochondria which are important for energy production and immune system function. CoQ10 and alpha lipoic acid can both be helpful in protecting and supporting mitochondrial function by reducing oxidative stress. CoQ10 deficiency can lead to decreased energy production resulting in fatigue and increased free radical production. Fatigue is by far the most common symptom reported in Long COVID so CoQ10 is at the top of the list of supplements to try with this condition. Alpha lipoic acid is a powerful antioxidant, and it is involved in mitochondrial energy production. ALA also has immunomodulatory properties and may actually be an anti-viral as well. The properties of both nutrients in theory make them a promising combination in the treatment of Long COVID. How was the study done? 174 patients (51% male and 49% female) aged 18-81 (mean of 51) who had COVID-19 previously and met the 2015 National Academy of Medicine diagnostic criteria of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). 52% had comorbidities including chronic lung disease (16%, 28/174), diabetes mellitus (13%,23/174), psychiatric diseases (7.5%, 13/174), and rheumatic diseases (9.8%, 17/174). 17.8% (31) of patients had been previously hospitalized for severe respiratory SARS-CoV-2 pneumonia. 82.2% had mild/moderate symptoms during the acute phase. The mean duration of Long COVID symptoms was 5.9 months. The most common symptoms were fatigue (80%), impaired concentration (68%), sleep disorders (85%) disturbed smell and/or taste (60%), memory loss (45%), dyspnea (21%) and arthromyalgias (64%). Patients were divided into two groups. The first one (116 patients) received coenzyme Q10 (ubiquinone form) and alpha lipoic acid taken every day for two months at a dose of 100 mg of CoQ10 and 100 mg of alpha lipoic acid twice a day. The control group of 58 patients did not take either supplement. The characteristics of the patients in the two groups were similar at baseline. Patients in both groups also received a variety of medications including paracetamol, codeine, NSAIDS, antidepressants (duloxetine), anticonvulsants and analgesics (pregabalin and gabapentin). They also undertook psychological and psychiatric counseling, physio-kinesiotherapy, yoga, and Pilates. What were the results? “The primary end-point was to evaluate the effectiveness of the association of coenzyme Q10 and alpha lipoic acid in reducing fatigue, expressed as a reduction in Fatigue Severity Scale (FSS), at the second month (T1), of at least 50% (complete response) from the baseline (T0) or at least 20% (partial response) from the baseline (T0). A reduction in FSS < 20% from baseline at T1 was considered as a non-response. A complete FSS response was reached most frequently in the treatment group compared to the control group. An FSS complete response was reached in 62 (53.5%) patients in the treatment group and in two (3.5%) patients in the control group. A reduction in FSS score < 20% from baseline at T1 (non-response) was observed in 11 patients in the treatment group (9.5%) and in 15 patients in the control group (25.9%) (p < 0.0001).” Author's Conclusion “Despite the short follow-up period, we demonstrated a clinical benefit, suggesting the rapid effect of this therapy. On the other hand, because of the short follow-up duration, we do not know if this clinical benefit persists over time. Our results, all based on subjective indices, were definitely in favor of the treatment group.” Dr. Hedberg's Comments on Long COVID, CoQ10, and Alpha Lipoic Acid This study shows promising results in the use of coenzyme Q10 and...

Claudia Jakubzick grew up in south Florida, the second daughter of Peruvian immigrants. Her childhood was filled with fun and love, then later partying and parental neglect. She graduated from high school with a third-grade reading level, but she was determined to not be a “loser.” On episode 134, Claudia shares how she found the will to forge a new path for her future. She pursued her childhood passion for science, and today, she is an associate professor within Dartmouth's Department of Microbiology and Immunology. She tells Sarah about her relationship with her parents today and how she, in turn, parents her three children. Show Notes: - Read Claudia's article in Journal of Experimental Medicine: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400547/

Not all jaw pain is TMJ - but there can be lots of issues here from muscular tension and pain to arthritic changes in the joint. The more you can understand HOW the temporomandibular joint actually functions, the better decisions you can make about what the next best step is for you. So whether you suffer from tension headaches, jaw pain, neck pain, or are just curious - today's episode is for you. You'll learn: All about TMJ (aka temporomandibular joint) Why headaches and TMJ issues go hand in hand The best massage and self-care techniques to address jaw pain All the links: Jaw Pain Self-Care Guide Easy massage for jaw pain (no equipment!) (AE Wellness YouTube) Jaw and TMJ Relief with Yoga Tune Up Therapy Balls (AE Wellness YouTube) Neck Massage with Yoga Tune Up Therapy Balls (AE Wellness YouTube) Massage Therapy in Myofascial TMD Pain Management (Advances in Clinical and Experimental Medicine, Wroclaw Medical University Press, Poland, 2012) Nonpharmacological therapies for temporomandibular disorders: a review (Medical Data Mining, 2020) Epidemiological analysis on 2375 patients with TMJ disorders: basic statistical aspects (Annali de Stromatologica [Rome]) 2013 30 days to more strength + flexibility with the Mobility Mastery Toolkit Movement Mavens has the tools and strategy to support you on your path to enjoying life without pain - www.aewellness.com/mavens www.aewellness.com/podcast - Show notes, links and more. Join the free Body Nerds FB community: https://www.facebook.com/groups/aewbodynerds/ Come hang out with me on Instagram @hollaformala : https://instagram.com/hollaformala/ TikTok @ aewellness Bodywork Starter Guide - learn the 6 places you need to roll right now for quick relief, plus the reason why what you've tried so far has only given you a temporary fix. Download the guide for free now at www.aewellness.com/bodywork 818-396-6501 is the Body Nerd Hotline - how do you build consistency and/or where are you getting stuck? Drop me a line and let me know your body nerd hacks - you might just hear your voice on a future episode! Today's episode is brought to you by Mobility Mastery Toolkit. Forget icing and stretching - and get a simple program you can do on your own that actually works. The Toolkit includes 30-days of exercises so you know exactly what to do to improve the mobility of your hips, lower back, feet, neck and shoulders. With video demos and a full-body mobility workout calendar, you're just 15-mins a day from feeling stronger and more flexible. Get $20 off when you use the code MASTERY at www.mobilitytoolkit.co

Endoscopic pyloromyotomy (G-POEM) is a minimally invasive treatment option with promising uncontrolled outcome results in patients with gastroparesis. Dr Philip Smith, Digital and Education Editor of Gut, interviews Professor Jan Martinek, from the Department of Hepatogastroenterology, Institute of Clinical and Experimental Medicine, Prague, Czech Republic, about his paper on this topic. The article titled 'Endoscopic pyloromyotomy for the treatment of severe and refractory gastroparesis: a pilot, randomised, sham-controlled trial' is published in paper copy in Gut in November 2022 and available online at: https://gut.bmj.com/content/71/11/2170 Please subscribe to the Gut Podcast via all podcast platforms, including Apple Podcasts, Google Podcasts, Stitcher and Spotify, to get the latest podcast every month. If you enjoy our podcast, please consider leaving us a review or a comment on the Gut Podcast iTunes page (https://podcasts.apple.com/gb/podcast/gut-podcast/id330976727).

Dr. Martina Sollini is an Assistant Professor at Humanitas University in Italy. She is physician researcher board-certified in Nuclear Medicine, and has a PhD in Molecular and Experimental Medicine. Dr. Sollini is a Principal Investigator of many clinical trials focused on oncological imaging and radioimmunotherapy. She has authored or co-authored of over 60 papers in international peer reviewed journals as well as 20 book chapters. In 2019 , she won the “Francesco de Luca” International Prize. Here is the article we discussed: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7913037/ --- Support this podcast: https://anchor.fm/healingispossible/support

What motivates people to seek and maintain fitness and wellness? How do expectations for fitness and wellness differ for younger people and older people? Do chaotic events, such as a pandemic or health scare, catapult people toward action to increase fitness and wellness? What feedback or rewards help people to stay motivated and act in ways to promote fitness and wellness? In this show, fitness professional Megan Usui helped us to understand and find answers to those questions. In addition, Megan and David time travel to March of 2020 to inform a hypothetical national fitness campaign. ABOUT MEGAN USUI. Megan Usui has worked as a fitness director, personal trainer, weight loss coach, gym designer and group fitness instructor at health clubs, weight loss and biofeedback centers in California, New York, Virginia and Washington State, including the Washington Athletic Club in downtown Seattle. WHAT MOTIVATES PEOPLE TO SEEK AND MAINTAIN FITNESS AND WELLNESS? Megan begins by asking, “How can I help you?” She also guides people to define the concept of “fit.” Most of her clients aren't seeking to improve their time running a mile. Megan educates clients about better eating habits. What are carbohydrates, proteins, and fats? She made a color-coded food type and portion wheel for her sons. HOW DO EXPECTATIONS FOR FITNESS AND WELLNESS VARY FOR PEOPLE OF DIFFERENT AGES? Megan shares that BOOMERS want to do basic things like get down on the floor and play with their grandkids or walk up the driveway without huffing. Megan talked about “Silver Sneakers,” a program available from Medicare at no cost for adults age 65+ and honored by most gyms. GEN X wants to stay active. These are people in their 40s or early 50s and want to look better and keep up with their now-in-their-20s children. MILLENNIALS tend to plug into whatever app or fitness equipment is available to them. They buy expensive Peloton bikes and are happy to stay at home. TEENS associated fitness with ‘coolness,' although that doesn't seem to be true today. Megan shared that frustrated parents come to her asking for ways to get their screen-addicted kids out of their rooms. Teens are interested in their virtual presence. DO CHAOTIC EVENTS, SUCH AS A PANDEMIC OR HEALTH SCARE, CATAPULT PEOPLE TOWARD ACTION TO INCREASE FITNESS AND WELLNESS? At the onset of the pandemic, some people hid under a blanket when their gym closed. Other people bought all the fitness equipment that they could. Are we a fighter? Or, are we someone that flees? Surprisingly, chaotic events don't motivate the populace toward fitness. WHAT FEEDBACK OR REWARDS HELP PEOPLE TO KEEP MOTIVATED AND ACT IN WAYS TO PROMOTE FITNESS AND WELLNESS? As for FitBits, wearables, and online fitness leaderboards, Megan believes those appeal to some people, but are incomplete. And, who are you accountable to? An app? So, they might get 10,000 steps a day, but are they improving their overall health? And, individual rewards mean more than a mass-produced fitness patch. FITNESS AND FORTITUDE CAMPAIGN. How might the American government introduce a civilian fitness program designed to encourage people of all ages and abilities to improve their health and fitness through formal physical exercise training and other wellness activities? What was possible in March and April of 2020? (The following excerpt is from ‘The Velocity of Information - Human Thinking During Chaotic Times' (2022). “We know fitness and nutrition are good for everyone, for all living creatures. Not just good for the body, but good for the mind. [T]he COVID-19 fitness research was falling into place, too. In a July 2020 study published in the Journal of Clinical and Experimental Medicine, researchers wrote, ‘The practice of physical activities strengthens the immune system, suggesting a benefit in the response to viral communicable diseases. Thus, regular practice of adequate intensity is suggested as an auxiliary tool in strengthening and preparing the immune system for COVID-19.'” Megan noted that music is a motivator in group exercises. She suggested that a contemporary national fitness campaign might be similar to the 1985 charity song “We Are the World” that was played around the globe with a message to prompt the listener to make a decision to give support and save others' lives (famine) because in doing that, they are indirectly saving the whole human race. Recording artists, celebrities, and influencers could partner with Nike for a “Just Do It” type of song about moving and in that song, demonstrate squat, push, pull. Merely listening to the song might evoke some volitional muscle contractions! The tune could be called “The Pandemic Shuffle.” SAFETY DOC WEBSITE, BLOG & BOOKS: www.safetyphd.com. The Safety Doc Podcast is hosted & produced by David P. Perrodin, PhD. This podcast and blog post represent the opinions of David P. Perrodin and his guests to the show. This is episode 190 of The Safety Doc Podcast published on 10-12-2022. Purchase Dr. Perrodin's Books: School of Errors – Rethinking School Safety in America. www.schooloferrors.com Velocity of Information - Human Thinking During Chaotic Times. www.velocityofinformation.com

VIDEOS: The elite that has taken almost all the money is now after everything else as well | Neil Oliver The Metaverse Is Worse Than You Thought – by MOON 11 reasons an annual COVID-19 booster is NOT LIKE an annual flu shot Blackcurrant nectar shows exercise benefits for college students: Study University of the Incarnate Word, September 14, 2022 Daily consumption of blackcurrant nectar for eight days may reduce muscle damage and inflammation after exercise, according to a new study from scientists at the University of the Incarnate Word in San Antonio, Texas. Sixteen ounces per day of the blackcurrant nectar were associated with reductions in the activity of creatine kinase, a blood marker of muscle damage, by 6.7%, compared to 82% increases in activity in the placebo group 48 hours after exercise, report the researchers in the Journal of Dietary Supplements . Researchers led by Alexander Hutchison, PhD, also report that levels of the inflammatory compound interleukin-6 decreased after exercise in participants in the blackcurrant group, compared with increases seen in the placebo group. “In partial support of our primary hypotheses, we found that consumption of black currant nectar for four days before and three days after a bout of eccentric leg exercise significantly reduced circulating markers of muscle damage while maintaining circulating antioxidant capacity,” they wrote in their paper. “Although pain scores in the blackcurrant nectar group returned to baseline a day earlier than the placebo group, there were no significant differences observed between groups at any time point after exercise. The study included 16 college students randomly assigned to consumer either the blackcurrant nectar beverage (CurrantC provided by CropPharms from Staatsburg, NY) or placebo twice a day for eight days. On day 4 the participants performed a bout of knee extension exercises, and blood samples taken 24, 48, and 96 hours after the exercise. Results showed that ORAC levels in the blood significantly decreased in the placebo group, while no significant decreases from the baseline values were observed in the blackcurrant group. In addition, significant differences between the groups were observed for IL-6 levels 24 hours after exercise, while significant differences were observed in creatine kinase activity between the groups after 48 and 96 hours.. How does what we eat affect our health span and longevity? It's a complex, dynamic system Columbia University's Mailman School of Public Health, September 21, 2022 How does what we eat affect how we age? The answer to this relatively concise question is unavoidably complex, according to a new study at the Butler Columbia Aging Center at Columbia University Mailman School of Public Health. The findings are published online in the journal BMC Biology. While most analyses had been concerned with the effects of a single nutrient on a single outcome, a conventional, unidimensional approach to understanding the effects of diet on health and aging no longer provides us with the full picture: A healthy diet must be considered based on the balance of ensembles of nutrients, rather than by optimizing a series of nutrients one at a time. Until now little was known about how normal variation in dietary patterns in humans affects the aging process. “”This study therefore provides further support to the importance of looking beyond ‘a single nutrient at a time' as the one size fits all response to the age-old question of how to live a long and healthy life.” Cohen also points that the results are also concordant with numerous studies highlighting the need for increased protein intake in older people, in particular, to offset sarcopenia and decreased physical performance associated with aging. The researchers analyzed data from 1,560 older men and women, aged 67-84 years selected randomly from the Montreal, Laval, or Sherbrooke areas in Quebec, Canada, who were re-examined annually for three years and followed over four years to assess on a large scale how nutrient intake associates with the aging process. Aging and age-related loss of homeostasis (physiological dysregulation) were quantified via the integration of blood biomarkers. The effects of diet used the geometric framework for nutrition, applied to macronutrients and 19 micronutrients/nutrient subclasses. Researchers fitted a series of eight models exploring different nutritional predictors and adjusted for income, education level, age, physical activity, number of comorbidities, sex, and current smoking status. Four broad patterns were observed: The optimal level of nutrient intake was dependent on the aging metric used. Elevated protein intake improved/depressed some aging parameters, whereas elevated carbohydrate levels improved/depressed others; There were cases where intermediate levels of nutrients performed well for many outcomes (i.e. arguing against a simple more/less is better perspective); There is broad tolerance for nutrient intake patterns that don't deviate too much from norms (“homeostatic plateaus”). Optimal levels of one nutrient often depend on levels of another (e.g. vitamin E and vitamin C). Simpler analytical approaches are insufficient to capture such associations. Mediterranean diet could play a key role in preventing cognitive decline Brigham and Women's Hospital and Harvard University, September 20, 2022 Individuals of minoritized ethnic or racial groups are often underrepresented in research, thus hindering the understanding of risk factors and the efficacy of treatments for diseases in these minoritized groups. A recent study published in the journal Alzheimer's & Dementia found that the levels of six plasma metabolites were associated with lower cognitive function across all racial/ethnic groups, and the levels of most of these blood metabolites were associated with adherence to a Mediterranean diet. Speaking to Medical News Today, the study's corresponding author Dr. Tamar Sofer, a professor at Brigham and Women's Hospital at Harvard University, said: “We identified a few metabolites (small molecules) in blood that their levels are correlated with cognitive function, and they are all related to diet. Characterizing metabolites associated with cognitive function can help researchers understand the mechanisms underlying the development of dementia. Moreover, blood metabolites can be easily measured and could serve as biomarkers for cognitive function. A previous study involving older Puerto Rican individuals showed that the levels of 13 blood metabolites were associated with global cognitive function, which is a composite measure of multiple cognitive abilities. Metabolite levels are influenced by the interplay between genetics, health status, and environmental factors, including diet, other lifestyle factors, and socioeconomic factors, which may differ among and even within ethnic/racial groups. The meta-analysis showed that six blood metabolites were associated with lower cognitive function across all ethnic/racial groups. Four out of the six metabolites associated with overall cognitive function were sugars, including glucose, ribitol, mannose, and mannitol/sorbitol. Out of the six metabolites, the analysis revealed a potential causal effect of only ribitol on cognitive function. The researchers also assessed the association between dietary habits, including adherence to a Mediterranean diet and intake of food groups (i.e. intake of legumes, fruits, vegetables, meat, fish, etc.), and blood metabolite levels. They found that adhering to a Mediterranean diet or its component food groups was correlated with several blood metabolites assessed in the study. Notably, the strongest association was observed between beta-cryptoxanthin and fruit intake participants. Beta-cryptoxanthin is a carotenoid with antioxidant properties found in fruits and vegetables, and beta-cryptoxanthin levels are associated with a lower risk of insulin resistance and liver dysfunction. “[T]his study is a step in the right direction in relation to examining the role of diet and the body's metabolism for brain health. It provides suggestive evidence that adherence to a good diet such as the Mediterranean style diet may be beneficial for brain health over a wide age range.” Indigo Rose Tomatoes Contain An Antioxidant That Fights Diabetes, Cancer and Neurodegenerative Diseases Oregon State University, September 15, 2022 Not only do dark tomatoes turn heads, but they are also healthier than normal red varieties, according to plant scientists. Indigo Rose Tomatoes were cultivated by breeding red and purple tomato plants, and are being heralded as a new superfood with potent antioxidants. Scientists bred purple tomatoes containing anthocyanin, an antioxidant said to help fight several diseases, with normal red varieties. ‘There are some dark coloured tomatoes but Indigo Rose is the only real black tomato and is the darkest that has ever been bred. “It's not genetically modified or GMO-based as many assume,” said Botanist Marjorie Varga. “People often get confused between GMO and hybridization which farmers have been using to cultivate new plant varieties for thousands of years.” “It is the first improved tomato variety in the world that has anthocyanins in its fruit,” he said. Myers' team found some tomatoes with purple pigmentation and tests revealed that anthocyanins were providing the colour, the same as blueberries. They crossed the purple tomatoes with some wild tomatoes and eventually came up with a black strain. Foot massage effective in improving sleep quality and anxiety in postmenopausal women Çankiri Karatekin University (Turkey), September 21, 2022 The therapeutic benefits of massage have long been recognized. A new study suggests that foot massage, in particular, can help minimize a number of common menopause symptoms, including sleep disruption, effectively extending sleep duration by an average of an hour per day. Study results are published online today in Menopause. During the menopause transition, estrogen deficiency can lead to a number of physical and mental health problems, including insomnia, hot flashes, vaginal dryness, headaches and anxiety. Although hot flashes and negative moods commonly seen in in the menopause transition often improve, conditions such as sleep complaints and vaginal dryness tend to persist or worsen over time. Previous studies have suggested that foot reflexology is an effective intervention in reducing stress and fatigue in premenopausal women. However, no previous studies were found that evaluated the effects of foot massage on anxiety, fatigue and sleep at the same time in postmenopausal women. In this new, small-scale study, researchers specifically sought to evaluate the effects of foot massage on anxiety, fatigue and sleep in postmenopausal women. Study results determined that foot massage applied during menopause increases the average daily sleep duration—as much as an hour per day—and reduces women's fatigue and anxiety levels. “Sleep disturbances, fatigue and anxiety symptoms are common during menopause. This small study in Turkish women shows how a simple, inexpensive intervention such as foot massage can improve these bothersome symptoms in postmenopausal women. Lack of sleep negatively impacts immune stem cells, increasing risk of inflammatory disorders and heart disease Icahn School of Medicine at Mount Sinai, September 21, 2022 Chronic insufficient sleep can negatively affect immune cells, which may lead to inflammatory disorders and cardiovascular disease, according to a new study from the Icahn School of Medicine at Mount Sinai. More specifically, consistently losing an hour and a half of sleep a night potentially increases the risk. The research, published in the Journal of Experimental Medicine, is the first to show that sleep alters the structure of DNA inside the immune stem cells that produce white blood cells—also known as immune cells—and this can have a long-lasting impact on inflammation and contribute to inflammatory diseases. Immune cells fight infection, but if the number of these cells gets too high, they overreact and cause inflammation. The study is also the first to show that catching up on sleep doesn't reverse the effects of sleep disruption. “This study begins to identify the biological mechanisms that link sleep and immunological health over the long-term. It shows that in humans and mice, disrupted sleep has a profound influence on the programming of immune cells and rate of their production, causing them to lose their protective effects and actually make infections worse—and these changes are long-lasting. This is important because it is yet another key observation that sleep reduces inflammation and, conversely, that sleep interruption increases inflammation,” says lead author Filip Swirski, Ph.D., Director of the Cardiovascular Research Institute at Icahn Mount Sinai. “This work emphasizes the importance of adults consistently sleeping seven to eight hours a day to help prevent inflammation and disease, especially for those with underlying medical conditions.” A team of investigators analyzed 14 healthy adults who regularly sleep eight hours a night. First, researchers monitored them sleeping at least eight hours a night for six weeks. They drew their blood and analyzed their immune cells. Then, the same group of adults reduced their sleep time by 90 minutes every night for six weeks, and had their blood and immune cells reanalyzed. At the end of the study researchers compared the blood and cell samples from the full night's sleep and restricted sleep periods. All participants had significant changes in their immune cells (also known as hematopoietic cells) due to a lack of sleep—there were more of them, and the DNA structure was altered. After six weeks of sleep restriction, they had an increased number of immune cells. Results in humans showed that fragmented sleep had significant changes to their immune stem cells, producing an increased number of immune cells, and also showed evidence of rewiring and reprogramming. A notable finding from the mouse group was that even after sleep recovery, the immune stem cells retained this rewiring structure, and they continued to produce additional white blood cells, making the mice susceptible to inflammation and disease. “Our findings suggest that sleep recovery is not able to fully reverse the effects of poor-quality sleep. We can detect a molecular imprint of insufficient sleep in immune stem cells, even after weeks of recovery sleep. This molecular imprint can cause the cells to respond in inappropriate ways leading to inflammation and disease,” says co-lead investigator Cameron McAlpine, Ph.D., Assistant Professor of Medicine (Cardiology) at Icahn Mount Sinai.

GUEST OVERVIEW: Dr. Christopher Shaw is a Professor of Ophthalmology and Visual Sciences and holds cross appointments with the Department of Experimental Medicine and the Graduate Program in Neuroscience. He is the author of more than 100 peer-reviewed articles as well as numerous book chapters and special reviews.

This episode presents a recorded conversation between students in my research lab at the University of British Columbia, discussing the article, “A home‑based pulmonary rehabilitation mHealth system to enhance the exercise capacity of patients with COPD: development and evaluation”, published in 2021 in the BMC Medical Informatics and Decision Making journal with Ning Deng as the first author. The link to the article is here. The students' previously did a journal club discussion similar to this episode on a different article. The link to that episode is here. A previous episode of the podcast talked about setting up your own journal club. The link to that episode is here. Students who took part in this conversation include: Débora Petry-Moecke, PhD student in Rehabilitation Sciences, Ivan Kamurasi, a recent graduate in MSc in Experimental Medicine, Justin Turner, PhD student in Rehabilitation Sciences, Maryke Peter, MSc student in Experimental Medicine, Dr. Stacy Maddocks, Postdoctoral Researcher, and Sunaina Chopra, MSc student in Rehabilitation Sciences. The full list of my students and other lab members can be found here. The papers that Débora mentioned in the episode can be found here and here. The paper that Justin mentioned in the episode can be found here. The papers that Stacy mentioned in the episode can be found here and here.

Daryl Black Eagle Jamieson is part of Medicine Singers, a collaborative project featuring the Israeli guitarist Yonatan Gat and the Eastern Medicine Singers, an Eastern Algonquin powwow group based in Providence, RI. The group's self-titled debut album, released on Joyful Noise Recordings, features a radical mix of traditional and experimental sounds that has attracted some serious attention.

Explore how Medicine Singers blend traditional and experimental sounds in their music.

Professor Luke O'Neill, Professor of Biochemistry at the school of Immunology, Trinity College and Professor Peter Openshaw, Professor of Experimental Medicine at Imperial College London and vice-Chair or NERVTAG, a UK Department of Health committee horizon-scanning for emerging respiratory threats both joined Pat in studio to discuss the future of Covid-19.

"Learn about the fascinating field of mucosal immunology, vaccine effectiveness, and the role of face-mask protection not from virus particles but “spiticles and snoticles”. Dr Peter Openshaw, ESWI Board Member and Professor of Experimental Medicine, Imperial College London, expertly guides us through what led to the unprecedented speed of COVID-19 vaccine development. From his experience of two pandemics, he offers a vision of future variants and how SARS-COV-2 is continuing to evolve.”This podcast is kindly sponsored by Viatris. 

This Week In Wellness a recent study by McGill University's Division of Experimental Medicine, published in Science Translational Medicine shows that inflammation may in fact be necessary for healing acute injuries, throwing into question the common use of steroids and over the counter anti-inflammatories as a first line of defence. “This was very, very unexpected,” Listen In The post TWIW 153: Do anti-inflammatories cause chronic pain? appeared first on The Wellness Couch.

In this episode I discuss: -A brief history of Merck's Gardasil HPV Vaccine -Ways that I've practiced using my voice (for better or worse) -What I would/wouldn't do again -Getting over the fear of standing up to authority and someone who “had my best interest” -Working through feelings of betrayal and sadness around my mothers' lack of informed consent -The value of sitting in discomfort when you don't get the response you want -Exploring responsibility in sharing life saving information This particular confrontation with my pediatrician of nearly 20 years was essential practice and laid the framework for using my voice with c0vid and transgender ideology. Resources: The HPV Vaccine On Trial: Seeking Justice For A Generation Betrayed HPV -2006 Warning HPV vaccine carries 25% chance of lifelong sterilization, study finds A case–control study of quadrivalent human papillomavirus vaccine-associated autoimmune adverse events. Merck Accused of Fraud, Deceit and Negligence in US Gardasil Case Behavioral abnormalities in female mice following administration of aluminum adjuvants and the human papillomavirus (HPV) vaccine Gardasil Too fast or not too fast: the FDA's approval of Merck's HPV vaccine Gardasil The FDA meeting transcripts from: VACCINES AND RELATED BIOLOGICAL PRODUCTS ADVISORY COMMITTEE Learn more about healing your cervix: http://www.sisterzeus.com/dysplasia.html ➢➢➢ SUPPORT THE PODCAST | https://www.paypal.com/paypalme/whosebodyisit?locale.x=en_US 1:1 COACHING SOVEREIGN WOMEN | https://www.whosebodyisit.com/coaching-for-sovereign-women HYPNOSIS FOR HEALING & RADICAL CHANGE | https://www.whosebodyisit.com/hypnosis SHOP ACTIVIST STICKERS | https://www.whosebodyisit.com/shop INSTAGRAM | https://www.instagram.com/whosebodyisit/

Intro (00:00) John introduces the team of Sue Paterson and Paul Heasman, ready for another fascinating conversation with the special guest, Ross Walker.   Log this CPD with 1CPD here   Chapter 1 – What is hypochlorous? (02:05) Sue introduces Ross Walker to the podcast. Ross describes himself as Director of Clinical Health Technologies, which manufacture products based on a high purity of hypochlorous solution; this has been in the human market with the Clinisept brand, and is now moving into the animal sector with the Contego brand via Nextmune.   (02:52) Sue asks Ross how he got into working with hypochlorous acid. Ross says having worked in London and then wanting to change, he was approached to work in the field of producing a highly stabilised hypochlorous acid.   (03:35) Sue asks what hypochlorous acid is and Ross describes it as the most effective disinfectant agent known to man, but is also completely skin compatible to any mammals- so it kills things you want to get rid of without doing any harm to humans or animals.   (04:12) Sue asks how this works, and why it isn't a concern that it has the word acid in it. Ross says this is because it is an acid with a skin neutral pH, so it is non-irritant, non-sensitising and non-cytotoxic. He says it originates in our body in order to deal with invading organisms, through the process of phagocytosis - the blood cells in our body produce low concentrations  and low quantities of hypochlorous.   (05:37) John ponders what the catch is and why this isn't already widely used in the human sector and more generally. Ross describes hypochlorous Archilles' heel - describing the first discovery of hypochlorous occurring during the first world war in 1915, where when soldiers had severe wounds as well as having been exposed to chlorine gas, it was discovered that they healed much quicker than those who had had the severe wounds without the exposure to chlorine gas. This was found to be due to the chlorine forming a solution in the water within the trenches, and this forming a level of cleanliness. The soldiers exposed to the chlorine gas we're also found to have high levels of cleanliness within the wounds. The papers published at the time concluded three things: firstly that hypochlorous was a very effective disinfectant, being bactericidal, fungicidal, viricidal and sporicidal. Secondly that it had a skin neutral pH, so therefore was contributing bacterial resistance without causing skin trauma. And thirdly, that this contributed to the perfect environment for skin healing, maintaining cleanliness without causing tissue trauma.   (08:19) Sue asks the difference between this and hypochlorite (bleach). Ross says that the two are derived from the chlorine chemistry, but that hypochlorite or bleach, is far more skin irritant, as many with no not wanting to have bleach on the skin. But that it is actually also much less effective in killing bacteria then hypochlorous. Ross demonstrates this by saying that an examination of a bottle of bleach would show a very high parts per million concentration, because hypochlorite has to be in very high concentrations in order to be effective; whereas hypochlorous can be in a much lower concentration in order to achieve the same level of efficacy.   Chapter 2: Why isn't it being used in people? (09:51) John asks again whether this is something that is available on the human market and Ross confirms that over the years the number of companies have bought this product in the market, and much research has been done. However, it never achieves its potential because of the Achilles heel mentioned previously. Hypochlorous has a half life of 48 hours, meaning if you manufacture it you need  do something with it quickly before it starts to decay; this is due to its manufacture, which in 1915 was by electrolysis – passing an electric current through a saline solution and generating a quantity of hypochlorous from the anode. This method of manufacture has remained since 1915 until recently, when a new method that Ross uses came in (using a chemical method to manufacturer it). Stabilising techniques used on the electrolysis method, have always produced a low level of concentration, a low level of stability and a low level of purity. Ross says their method pulls the rug from under these Achilles' heels, providing a shelf life of two years, as well as a high level of stability and of concentration - in excess of 90% hypochlorous in comparison to the previous iterations of around 60%   (12:13) Sue asks about the applications being used in the human field already. Ross shares that they initially needed to verify the efficacy of their version of hypochlorous, and so they compiled a study involving ear piercing, with the largest manufacturer of ear piercings and the largest ear-piercing company, and have pierced in excess of 20 million ears using their version of hypochlorous as the after-care. During that time they have had zero reports of infection following the piercing, and that it has enabled the manufacturer to halve the healing time from six weeks, down to 3 weeks. They then launched in the aesthetic sector, so it is used in the cosmetic industry and following the launch in June 2017 it had (by December 17) been given the 'Product of the Year' award in that sector. They have also since gone on to work in the podiatry sector as well as the dental sector with a mouth rinse - in all of these instances the product is doing exactly the same thing, maintaining cleanliness without damaging the tissue and therefore improving skin healing time.  Ross adds that it has applications in venous and diabetic leg ulcers, where it is very effective due to its efficacy on removing biofilms.   Chapter 3: How can it help animals? (15:13) John asked whether this is safe to use in animals as well as people, and what species. And Ross confirms that it is safe to use in all mammals, so including small animals and large animals such as livestock and horses. John goes on to ask the application in these animals and Ross says this application is very widespread, not simply for wound healing applications but also for instances of skin contamination, eczema and dermatitis.   (16:28) Sue asks what papers have been published in the human field to demonstrate the efficacy of hypochlorous against things like yeast, staphylococcus and pseudomonas. Ross says a Wikipedia search will reveal approximately 3,500 papers published on the efficacy of the substance in disinfectant in these instances - and Ross says many papers have been published to prove its efficacy in European Normative standards. Hypochlorous uses an oxidising method of action to dissolve cell walls make it very quick in its effect, rather than those using a toxic method which is slower and can result in resistance as well as sometimes being toxic to the skin in too higher concentrations.   (18:27) Sue clarifies that this includes Malassezia, staphylococcus and pseudomonas and Ross confirms these are well within the capabilities of hypochlorous to kill these within 15 seconds.   (18:41) John asks about its effect with pus and cases of biofilm, with Ross saying it is very effective in these instances, crucially dissolving biofilm film as well as killing it. This means that with repeated application you can quickly remove the biofilm from the surface. Ross points out the physical action of rinsing is also beneficial to wash away the biofilm whilst also dissolving it, and Sue agrees that the resistant nature of biofilm contributes to the chance of resistance, and so disinfectant is a great benefit here. Ross confirms and points out a low level of infection can contribute to a biofilm which will delay healing and that there are many papers published in biofilm application for hypochlorous.   Chapter 3: Where does it fit with existing products? (22:25) Sue asks about the development of the use of topical therapy in treating bacterial overgrowth and infection on the skin, and whether hypochlorous could be used in a similar way to chlorhexidine in this application. Ross says that not only could it be used in this way, but it would do a much better job. Stating that chlorhexidine uses the aforementioned toxic method for killing bacteria, but this can also have some toxicity with the skin and slow skin healing in a way that hypochlorous doesn't. He also states there are growing number of plastic surgeons who are no longer prescribing routine antibiotics post-surgery when using hypochlorous, because they are so confident that it will prevent an infection from ever establishing!   (24:20) Sue asks about the possibility of hypochlorous being available as a shampoo rather than just a spray, because of the useful nature of a shampoo regardless of what is in it. Ross points out that the nature of hypochlorous means that it does not respond well to being mixed with other chemistry and so could never be formulated, as such there will always be a place for chlorhexidine-based formulations such as shampoos. Sue says that this therefore gives us a great choice for skin care and Ross echoes this.   (25:46) John asks how environmentally friendly hypochlorous is and Ross shares that hypochlorous has been given a category five by the environmental protection agency on their toxicity scale, which is the highest classification for environmental safety. Ross says that the nature of hypochlorous action, means that it uses up its efficacy as it decontaminates, so as it pours down the drain you will have a very clean first few metres of drain but by the time it makes it into the waterways it is benign.   (26:50) Sue summarises what we have learnt on the podcast and Ross agrees, saying it very quickly garnered the nickname 'game changer' when first launched. John asks how people may get hold of this and Ross says this is available over the counter via Nextmune to the animal industry.   Outro 29.36 John and Sue wrap up another insightful episode, with some musings of times gone by when hypochlorous acid might have been useful to the podcast panel.   Hypochlorous is available as Contego, from Nextmune UK – for information on how to order email salesenquiries.uk@nextmune.com   References A pilot study comparing in vitro efficacy of topical preparations against veterinary pathogens.  Uri, M. Buckley, L. Marriage, L. McEwan, N. Schmidt, V. (2016). Veterinary Dermatology. 27 (34), 152.   Antimicrobial efficacy of a very stable hypochlorous acid formula compared with other antiseptics used in treating wounds: in-vitro study on micro-organisms with or without biofilm Herruzo, R. Herruzo, I. Journal of Hospital Infection June 2020 105(2):289-294   Antibiofilm Efficacy of Polihexanide, Octenidine and Sodium Hypochlorite/Hypochlorous Acid Based Wound Irrigation Solutions against Staphylococcus aureus, Pseudomonas aeruginosa and a Multispecies Biofilm                                                                                                          Anne-Marie Salisbury, Marc Mullin, Rui Chen, Steven L. Percival 26 June 2021 pp 1-15 Advances in Experimental Medicine and Biology    Wound cleansing: benefits of hypochlorous acid. Joachim D, Journal of wound care [J Wound Care 2020 Oct 01; Vol. 29 (Sup10a), pp. S4-S8;

Dennis Gross M.D., F.A.A.D. Board-certified dermatologist and dermatological surgeon Dennis Gross, M.D., founded his practice in 1990 after completing his residency at the New York University Medical Center. With a deep interest in skin that is healthy as well as beautiful, Dr. Gross has executed extensive research at prestigious institutes, including Memorial Sloan-Kettering, on melanoma. His research on skin cancer has been published in multiple peer-reviewed journals, including Journal of Experimental Medicine and Journal of Medical Microbiology. Dr. Gross' affiliations have included the Skin Cancer Foundation, American Cancer Society, as well as the American Academy of Dermatology, the Society for Dermatological Surgery and Oncology, the American Medical Association, and the New York Dermatology Society. Dr. Gross is a leader in cosmetic dermatological procedures, providing access to cutting-edge technology that provides exceptional results. He is passionate about achieving symmetry and balance in the faces of his patients and customizes his technique for all his treatments, allowing him to suit all of his patients' needs and desires. He takes a subtle approach to fillers, believing that the most naturally enhanced appearance is one that can be achieved in stages. Dr. Gross created his award-winning product line, Dr. Dennis Gross SkincareTM, in 2002. He and his skincare expertise have been featured in publications including The New York Times Magazine, Elle, Vogue, and Harper's Bazaar, in addition to guest appearances on The Today Show, CNN, and The Early Show. Dr. Gross is a native New Yorker. He resides in Manhattan with his wife and business partner, Carrie, and their four children. --- Send in a voice message: https://anchor.fm/skincareanarchy/message Support this podcast: https://anchor.fm/skincareanarchy/support

Featuring guest speakers Timeo Mtenga from the Malawi Liverpool Wellcome Trust and Naomi Walker from the Liverpool School of Tropical Medicine, this episode looks as TB treatment challenges and future solutions- we cover topics including:  The challenges faced by people living with TB  The complexity of TB treatment  Guests' new research on TB treatment, and how this will affect change Dr Naomi Walker Senior Clinical Lecturer in Experimental Medicine, LSTM  Consultant in Infectious Diseases and General Internal Medicine, Liverpool University Hospitals NHS Foundation Trust  I am a clinical academic specialising in Tropical Medicine and Infectious diseases. My major research interest is TB immunopathology and the influence of HIV infection on TB disease. I completed my PhD at Imperial College London and at University of Cape Town. Before moving to Liverpool, I was a Clinical Lecturer at London School of Hygiene and Tropical Medicine. In addition to UK, I have clinical experience working in South Africa, Tanzania, Uganda, Sierra Leone and Australia.  Timeo Mtenga Research Clinician, Malawi Liverpool Wellcome Trust I am Timeo Mtenga based in Zomba, Malawi. I have mainly studied HIV-TB, particularly in low resource settings. Under the LSHTM project, I am currently conducting two HIV-TB clinical trials (CASTLE and ITB-TBR) with the Malawi Liverpool Wellcome Trust research organisation. In my 5 years of research experience, the STAMP study contributed to policy formulation of HIV-TB management at the national level and internationally informed other partners like WHO. Now I am pursuing a Master's degree in Clinical Trials with the University of London. 

Daniel Chao, MD, PhD, spent a lot of years in the lab studying the nervous system of zebra fish and worms. No surprise, after earning his PhD in neuroscience, he wanted to move on.Ophthalmology reeled him in. After a residency and a fellowship in the field, he moved into a multifaceted research career that includes academia, biotech, and industry.As Senior Director of Translational and Experimental Medicine and Retina Clinical Lead for Janssen, the pharmaceutical arm of Johnson & Johnson, Dr. Chao designs and executes first-in-human and Phase II proof-of-concept studies for J&J's assets. He's also involved in developing biomarkers to help accelerate clinical trials and meeting with external partners.He knows where they're coming from. In 2019, he spun out technology he developed at UC San Diego into what is now Visgenx and became one of its scientific cofounders. Visgenx therapeutics are based on ELOVL2 gene expression, which is tied to aging in the retina and other tissues.Companies like Visgenx, take note: Janssen Retina is interested in both internal development as well as acquisition or partnerships as a route to innovative treatments.Listen to the conversation with Firas Rahal, MD to discover:The tech transfer and other pieces involved in taking Visgenx from scientific concept to funded startup.The mechanisms behind Visgenx's lead product.His thoughts on retina gene therapy and the top three challenges to wider-spread adoption.How he transitioned from academic researcher to Johnson & Johnson.The “hustle” involved in an academic research career.

Professor Juri Kropotov, Dr. Moshe Perl, and Mirjana Askovic joined our Neuropsychologist, Dr. Laura Jansons , and Neurofeedback legend Jay Gunkelman ] This was an awesome YouTube Show: https://youtu.be/me65JsGXk_Q Some of the topics discussed: Juri did a presentation on ERP vs QEEG ADHD Autism Anxiety PTSD Parkinsons Schizophrenia We thank our Patreon Supporters: https://www.patreon.com/NeuroNoodleFeatured Business: Outrageous Baking, Tor Talk, Joshua M of Alternative Behavioral Therapy, https://www.outrageousbaking.com/ https://tortalk.se/?lang=en https://neurofeedbackcare.com/ "EEG and Me". "Sandhya M", "Johnathan January-Turrall", "Rowan January-Turrall" "Loretta T" Have an idea for a topic or guest? pete@neuronoodle.com Jansons.com DrSkipHrin.com Prof. Juri Kropotov is a leading expert in the basic and applied neuroscience. The unique methodology developed in his labs at the Human Brain Institute in St Petersburg (Russia) allows a sophisticated analysis of brain electric activity in resting states and under task conditions. The methodology is described in his book Kropotov, J.D. (2009). Quantitative EEG, event-related potentials and neurotherapy. London: Academic Press. These precise measurements of brain function can be used as Neuromarkers in the clinical context to evaluate brain health in different psychiatric and neurological disorders. The experience of translating this methodology into clinical practice is presented in his recently published book Kropotov, J. D. (2016). Functional neuromarkers for psychiatry: Applications for diagnosis and treatment. San Diego, CA, US: Elsevier Academic Press. https://bmmi.wildapricot.org/AboutKropotov His scientific and research career spans 45 years of dedicated work in Brain science. Juri Kropotov, PhD. has earned three doctorates: in theoretical physics, in philosophy and neurophysiology. From 1970 to 1990, he practiced at the psychiatric clinics of the Institute of Experimental Medicine and Institute of the Human Brain at the Russian Academy of Sciences in St. Petersburg. Dr. Moshe Perl is a world-class expert in neurofeedback and QEEG/EEG analysis, areas in which he has almost two-decades of experience teaching and mentoring practitioners in Australia and internationally. He has successfully treated well over a thousand patients and has seen first-hand the amazing impact neurofeedback can have. Additionally, he has mentored over 100 practitioners in the field and reviewed thousands of cases inside of learning environments that develop and up-skill neurofeedback practitioners. Dr. Perl has studied with many of the recognized world-leading experts in neurofeedback and QEEG/EEG analysis, distilled their knowledge and has become a recognised leader in the industry. He applies his knowledge in clinical practice as well as in his teachings. A hallmark of Moshe's teaching style is that he makes difficult concepts accessible and understandable for students at any level of skill or knowledge. He consistently receives excellent feedback for his courses, both on and offline. https://www.neurotherapy.com.au/about/ Mirjana Askovic is a senior psychologist with 30 years of clinical experience in mental health.https://www.startts.org.au/about-us/ --- Send in a voice message: https://anchor.fm/neuronoodle/message Support this podcast: https://anchor.fm/neuronoodle/support

Hosts: Medical Student: Brooke Pace Quertermous Faculty: Katie McKie, MD Faculty: Ryan Harris, Ph.D Peer Review: Rebecca Yang, MD; Janelle McGill, MD During this episode, you will learn that Cystic Fibrosis is more than just a lung disease. Individuals with CF are also at risk for malabsorption, maldigestion, intestinal obstruction, exercise intolerance, and other systemic abnormalities. Dr. Katie McKie, Director of Pediatric Pulmonology at Augusta University, joins Dr. Ryan Harris, Founder and Director of the LIVEP and CF researcher, and Medical Student Brooke Quertermous to discuss the impact of nutrition and exercise on children with CF. Specifically, they will:  Explain the mechanism by which CF affects digestion and absorption of nutrients Acknowledge the importance of frequent growth monitoring for children with CF. Understand the role of nutrient supplementation for children with CF, and when enteral nutrition is required. Describe why exercise intolerance occurs in CF and the necessity of regular exercise for these patients. FREE CME Credit (requires sign-in): https://mcg.cloud-cme.com/course/courseoverview?P=0&EID=8631 Thank you for listening to this episode from the Department of Pediatrics at the Medical College of Georgia. If you have any comments, suggestions, or feedback- you can email us at mcgpediatricpodcast@augusta.edu Remember that all content during this episode is intended for informational and educational purposes only. It should not be used as medical advice to diagnose or treat any particular patient. Clinical vignette cases presented are based on hypothetical patient scenariosWe look forward to speaking to you on our next episode of the MCG Pediatric Podcast.   References: Gajbhiye, R., et al., Cystic fibrosis transmembrane conductance regulator (CFTR) gene abnormalities in Indian males with congenital bilateral absence of vas deferens & renal anomalies. Indian J Med Res, 2016. 143(5): p. 616-23. AND Elborn, J.S., Cystic fibrosis. Lancet, 2016. 388(10059): p. 2519-2531.) (Kuk, K. and J.L. Taylor-Cousar, Lumacaftor and ivacaftor in the management of patients with cystic fibrosis: current evidence and future prospects. Ther Adv Respir Dis, 2015. 9(6): p. 313-26.) (Farrell et al, Siret el al, Sims et al). Sullivan, J. S., & Mascarenhas, M. R. (2017). Nutrition: Prevention and management of nutritional failure in cystic fibrosis. Journal of Cystic Fibrosis, 16. doi:10.1016/j.jcf.2017.07.010 Committee On Practice And Ambulatory Medicine, & Workgroup, B. (2020, March 01). 2020 recommendations for Preventive Pediatric health care. Retrieved March 22, 2021, from https://pediatrics.aappublications.org/content/145/3/e20200013 Cystic Fibrosis Foundation, et al. Cystic Fibrosis Foundation evidence-based guidelines for management of infants with cystic fibrosis, J Pediatr 2009; 155(6 Suppl):S73-93.) (Nutrition Prevention and Management Article) (Mattar AC, Leone C, Rodrigues JC, Adde FV. Sweat conductivity: an accurate diagnostic test for cystic fibrosis? J Cyst Fibros. 2014 Sep;13(5):528-33. doi: 10.1016/j.jcf.2014.01.002. Epub 2014 Jan 31. PMID: 24485874.) Ameet Daftary, James Acton, James Heubi, Raouf Amin, Fecal elastase-1: Utility in pancreatic function in cystic fibrosis, Journal of Cystic Fibrosis, Volume 5, Issue 2, 2006, Pages 71-76,ISSN 1569-1993, Walkowiak, D. Sands, A. Nowakowska, R. Piotrowski, K. Zybert, K.H. Herzig, et al. Early decline of pancreatic function in cystic fibrosis patients with class 1 or 2 CFTR mutations J Pediatr Gastroenterol Nutr, 40 (2) (2005), pp. 199-201 Witt, H. (2003). Chronic pancreatitis and cystic fibrosis. Gut, 52(90002), 31ii-41. doi:10.1136/gut.52.suppl_2.ii31 Fielding, J., Brantley, L., Seigler, N., McKie, K. T., Davison, G. W., & Harris, R. A. (2015). Oxygen uptake kinetics and exercise capacity in children with cystic fibrosis. Pediatric Pulmonology, 50(7), 647-654. doi:10.1002/ppul.23189 Orenstein, D. (2018). The Relationship between CFTR Genotype and Exercise Tolerance in Cystic Fibrosis.. AnnalsATS, 15(2), 166. Marcotte JE, Canny GJ, Grisdale R, Desmond K, Corey M, Zinman R, Levison H, Coates AL. Effects of nutritional status on exercise performance in advanced cystic fibrosis. Chest. 1986 Sep;90(3):375-9. doi: 10.1378/chest.90.3.375. PMID: 3743150. Pastré, J., Prévotat, A., Tardif, C., Langlois, C., Duhamel, A., & Wallaert, B. (2014). Determinants of exercise capacity in cystic fibrosis patients with mild-to-moderate lung disease. BMC pulmonary medicine, 14(1), 1-8. Hulzebos, Erik H. J.1; Bomhof-Roordink, Hanna1,3; van de Weert-van Leeuwen, Pauline B.2; Twisk, Jos W. R.3; Arets, H. G. M.2; van der Ent, Cornelis K.2; Takken, Tim1 Prediction of Mortality in Adolescents with Cystic Fibrosis, Medicine & Science in Sports & Exercise: November 2014 - Volume 46 - Issue 11 - p 2047-2052 doi: 10.1249/MSS.0000000000000344 Ding S., Zhong C. (2020) Exercise and Cystic Fibrosis. In: Xiao J. (eds) Physical Exercise for Human Health. Advances in Experimental Medicine and Biology, vol 1228. Springer, Singapore. https://doi.org/10.1007/978-981-15-1792-1_26 Moorcroft AJ, Dodd ME, Morris J, Webb AK. Individualised unsupervised exercise training in adults with cystic fibrosis: a 1 year randomised controlled trial. Thorax. 2004 Dec;59(12):1074-80. doi: 10.1136/thx.2003.015313. PMID: 15563708; PMCID: PMC1746905. Pianosi P, Leblanc J, Almudevar A. Peak oxygen uptake and mortality in children with cystic fibrosis. Thorax. Jan 2005;60(1):50-54. LIVEP Contact: Reva Crandall at 706-721-5483.  

In this compelling history of the co-ordinated, transnational defence of medical experimentation in the nineteenth and early twentieth centuries, Rob Boddice explores the experience of vivisection as humanitarian practice. He captures the rise of the professional and specialist medical scientist, whose métier was animal experimentation, and whose guiding principle was 'humanity' or the reduction of the aggregate of suffering in the world. He also highlights the rhetorical rehearsal of scientific practices as humane and humanitarian, and connects these often defensive professions to meaningful changes in the experience of doing science. Humane Professions: The Defence of Experimental Medicine, 1876-1914 (Cambridge UP, 2021) examines the strategies employed by the medical establishment to try to cement an idea in the public consciousness: that the blood spilt in medical laboratories served a far-reaching human good. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this compelling history of the co-ordinated, transnational defence of medical experimentation in the nineteenth and early twentieth centuries, Rob Boddice explores the experience of vivisection as humanitarian practice. He captures the rise of the professional and specialist medical scientist, whose métier was animal experimentation, and whose guiding principle was 'humanity' or the reduction of the aggregate of suffering in the world. He also highlights the rhetorical rehearsal of scientific practices as humane and humanitarian, and connects these often defensive professions to meaningful changes in the experience of doing science. Humane Professions: The Defence of Experimental Medicine, 1876-1914 (Cambridge UP, 2021) examines the strategies employed by the medical establishment to try to cement an idea in the public consciousness: that the blood spilt in medical laboratories served a far-reaching human good.

In this compelling history of the co-ordinated, transnational defence of medical experimentation in the nineteenth and early twentieth centuries, Rob Boddice explores the experience of vivisection as humanitarian practice. He captures the rise of the professional and specialist medical scientist, whose métier was animal experimentation, and whose guiding principle was 'humanity' or the reduction of the aggregate of suffering in the world. He also highlights the rhetorical rehearsal of scientific practices as humane and humanitarian, and connects these often defensive professions to meaningful changes in the experience of doing science. Humane Professions: The Defence of Experimental Medicine, 1876-1914 (Cambridge UP, 2021) examines the strategies employed by the medical establishment to try to cement an idea in the public consciousness: that the blood spilt in medical laboratories served a far-reaching human good. Learn more about your ad choices. Visit megaphone.fm/adchoices

Barbara is completing her Ph.D. in Experimental Medicine at the University of British Columbia (UBC) where she also received her Masters of Science as well as her Bachelor of Kinesiology in Exercise Science. Her thesis focuses on Cardiovascular Risk Management and Screening in Masters Athletes to prevent adverse cardiac events during sport. She has worked in cardiac rehab at Vancouver General and St. Paul's hospitals and is a certified Clinical Exercise Physiologist through the American College of Sports Medicine. Her research is conducted through a MITACs industry partner, SportsCardiologyBC, where she is also the senior research and project coordinator. Barbara's ResearchGate Profile Barbara's Twitter *NOTE: I had some issues with sound during the podcast which I'm afraid I couldn't edit out. Please forgive the lower quality and hopefully it shouldn't take away from the great information that Barbara provides. In this episode we cover: Barbara's background in cardiac rehabilitation and what it means for cardiac care The benefits of exercise for reducing the risk of cardiac events in people who have already had one Barbara's observations in cardiac rehab that lead her to pursue here research in masters athletes who were highly active but still suffering from heart attacks What is sudden cardiac death in relation to exercise? Why does there seem to be higher rates of SCD in sports like cycling and running. The upsetting truth of what defines a masters athlete What is atherosclerosis and coronary artery calcification (CAC) and what does a CAC score mean for cardiac risk Why does calcium build up in arteries and how does exercise effect it? The importance of exercise for maintaining lifelong heart health The difference between calcified, non-calcified and mixed plaques and how that relates to exercise level The importance of proper recovery with endurance training for maintaining arterial health The difficulty in quantifying how much exercise is the "sweet spot" for heart health and how it varies according to fitness level Does strength/resistance training have similar effects on heart health? Barbara's research investigating the prevalence of cardiovascular disease in older athletes. What are some of the health markers that older athletes should keep an eye on and what other useful tests are available? Barbara's research into the heart health of bodybuilders (including steroid users)

Biópsias líquidas contra el cáncer En los micrófonos de El Método tenemos en esta ocasión a un amigo de los años de NYC, Héctor Peinado. Ahora dirige el laboratorio de microambiente y metástasis del CNIO. El perfil de Héctor en el CNIO https://www.cnio.es/personas/hector-peinado/ La noticia con la que abrimos la conversación "Journal of Experimental Medicine. Investigadores del CNIO determinan la progresión del melanoma mediante una nueva técnica de biopsia líquida" https://www.cnio.es/noticias/publicaciones/determinan-la-progresion-del-melanoma-mediante-una-nueva-tecnica-de-biopsia-liquida/ El nuevo spin-off EVOPOD ya está disponible aquí https://cuonda.com/evopod Vidrios y Barras puedes ecucharlo aquí https://cuonda.com/vidriosybarras Este contenido es gratis y sólo te pido que, si te ha gustado, entretenido, iluminado de algún modo, lo compartas en tus redes y nos valores en tu plataforma de pódcast favorita. Gracias ;)

The calories you burn in your workout today doesn't matter. Wait, what?That's right. It's not the energy expenditure of your workout that is going to stick with you. It's the long-lasting adaptations that your body creates due to the stress of your workout.The magic of your workout happens AFTER the workout.Adaptations like Rewiring of your cerebellum to prevent neurodegenerative diseaseImproved muscle density, size, and functionExcessive post-exercise oxygen consumptionStrength, power, stability, range of motionHormone modulationInjury preventionAre all paramount compared to caloric burnAnd it turns out that there are some great "secrets" that are proven to scientifically support your workout effort by boosting your recovery efforts! Mentioned in the show Weekly Updatesdefiningdadbod.com/ddb1Summer Shreddefiningdadbod.com/shredHow To Work Out While Sleep Depriveddefiningdadbod.com/blog/9Relora (for DHEA)https://www.amazon.com/gp/product/B0013YW7VC/ref=as_li_tl?ie=UTF8&camp=1789&creative=9325&creativeASIN=B0013YW7VC&linkCode=as2&tag=definingdadbo-20&linkId=309eb4cfcf945f373403399904e0cd4cReferences[1] Talbott SM, Talbott JA, Pugh M. Effect of Magnolia officinalis and Phellodendron amurense (Relora®) on cortisol and psychological mood state in moderately stressed subjects. Journal of the International Society of Sports Nutrition. 2013;10:37. doi:10.1186/1550-2783-10-37.[1] Increased free cortisol secretion after awakening in chronically stressed individuals due to work overload. Stress Medicine 1998; 14:91-97.[1] Shimomura Y, Murakami T, Naoya Nakai N, Nagasaki M, Harris RA (2004). “Exercise Promotes BCAA Catabolism: Effects of BCAA Supplementation on Skeletal Muscle during Exercise”. J. Nutr. 134 (6): 1583S–1587S. Retrieved 22 March 2011.[1] A O'Connor, S Simbo, et. Al. Powdered tart cherry supplementation moderates post-exercise immunosuppression, total cholesterol, and antioxidant status with no effect on performance recovery following an acute bout of intense lower body resistance exercise. A O'Connor, S Simbo, et. Al. Journal of the International Society of Sports Nutrition 2014 11(Suppl 1):P32. DOI: 10.1186/1550-2783-11-S1-P32.[1] Fassett, Robert G.; Coombes, Jeff S. (2009). “Astaxanthin, oxidative stress, inflammation and cardiovascular disease”. Future Cardiology 4 (3): 333–342.doi:10.2217/fca.09.19. PMID 19656058.[1] Hsu, C. H.; Cheng, A. L. (2007). “Clinical studies with curcumin”. Advances in Experimental Medicine and Biology 595: 471–480. doi:10.1007/978-0-387-46401-5_21. ISBN 978-0-387-46400-8. PMID 17569225.[1] Ftaiti F, Jemni M, Kacem A, Zaouali MA, Tanbka Z, et al. Effect of hyperthermia and physical activity on circulating growth hormone. Appl Physiol Nutr Metab. 2008;33(5):880-887[1] http://www.scientificamerican.com/podcast/episode/meditation-meta-analysis/[1] B L Alderman, R L Olson, C J Brush, and T J Shors. MAP training: combining meditation and aerobic exercise reduces depression and rumination while enhancing synchronized brain activity. Department of Exercise Science, Rutgers, The State University of New Jersey. Received 5 October 2015; Revised 1 December 2015; Accepted 5 December 2015Become a supporter of this podcast: https://www.spreaker.com/podcast/faithful-fitness-by-better-daily--5150768/support.

Today, our guest is Nils Brose, Professor and Director of the Dept. of Molecular Biology at the Max Planck Institute of Experimental Medicine in Göttingen, Germany. We speak with him about the mechanisms of neurotransmitter release, how synapses might be built, and the role of the luck in the career of a scientist.