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Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.11.523603v1?rss=1 Authors: Ziołkowska, M., Borczyk, M., Cały, A., Nalberczak-Skora, M., Nowacka, A., Sliwinska, M. A., Łukasiewicz, K., Skonieczna, E., Tomaszewski, K. F., Wojtowicz, T., Wlodarczyk, J., Bernas, T., Salamian, A., Radwanska, K. Abstract: The updating of contextual memories is essential for survival in a changing environment. Accumulating data indicate that the dorsal CA1 area (dCA1) contributes to this process. However, the cellular and molecular mechanisms of contextual fear memory updating remain poorly understood. Postsynaptic density protein 95 (PSD-95) regulates the structure and function of glutamatergic synapses. Here, using dCA1-targeted genetic manipulations in vivo, combined with ex vivo 3D electron microscopy and electrophysiology, we identify a novel, synaptic mechanism that is induced during attenuation of contextual fear memories and involves phosphorylation of PSD-95 at Serine 73 in dCA1. Our data provide the proof that PSD-95-dependent synaptic plasticity in dCA1 is required for updating of contextual fear memory. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.11.16.516790v1?rss=1 Authors: Rekad, Z., Ruff, M., Radwanska, A., Grall, D., Ciais, D., Van Obberghen-Schilling, E. Abstract: Endothelial cell interactions with their extracellular matrix are essential for vascular homeostasis and expansion. Large-scale proteomic analyses aimed at identifying components of integrin adhesion complexes have revealed the presence of several RNA Binding Proteins (RBPs) of which the functions at these sites remain poorly understood. Here, we explored the role of the RBP SAM68 (Src associated in mitosis, of 68 kDa) in endothelial cells. We found that SAM68 is transiently localized at the edge of spreading cells where it participates in membrane protrusive activity and the conversion of nascent adhesions to mechanically-loaded focal adhesions by modulation of integrin signaling and local delivery of {beta}-actin mRNA. Furthermore, SAM68 depletion impacts cell-matrix interactions and motility through induction of key matrix genes involved in vascular matrix assembly. In a 3D environment SAM68-dependent functions in both tip and stalk cells contribute to the process of sprouting angiogenesis. Altogether, our results identify the RBP SAM68 as a novel actor in the dynamic regulation of blood vessel networks. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.11.13.381368v1?rss=1 Authors: Ziolkowska, M., Borczyk, M., Nowacka, A., Nalberczak-Skora, M., Sliwinska, M. A., Robaca, M., Lukasiewicz, K., Caly, A., Skonieczna, E., Tomaszewski, K. F., Wojtowicz, T., Wlodarczyk, J., Bernas, T., Salamian, A., Radwanska, K. Abstract: The ability to update and extinguish fearful memories is essential for survival. 30 Accumulating data indicate that the dorsal CA1 area (dCA1) contributes to this process. 31 However, the cellular and molecular basis of fear memory updating remains poorly 32 understood. Postsynaptic density protein 95 (PSD-95) regulates the structure and function of 33 glutamatergic synapses. Here, we investigated the role of dCA1 PSD-95-driven synaptic 34 plasticity in contextual fear extinction. Using dCA1-targeted genetic manipulations in vivo 35 combined with PSD-95 immunostaining and 3D electron microscopy ex vivo, we demonstrate 36 that phosphorylation of PSD-95 at serine 73 PSD-95(S73) is necessary for contextual fear 37 extinction-induced expression of PSD-95 and remodeling of glutamatergic synapses. 38 Surprisingly, PSD-95 phosphorylation is not necessary for fear memory formation or early 39 extinction but is required for updating a partly extinguished fear memory, affecting its 40 persistence. Using a chemogenetic manipulation, we confirm that updating of the partly 41 extinguished fear requires PSD-95 expression and dCA1 activity during a prior extinction 42 session. Overall, our data indicate that dCA1 synapses are remodeled upon the extinction of 43 contextual fear memories; this process relies on PSD-95(S73) phosphorylation and enables 44 future updating of a partly extinguished contextual fear memory. These findings show how 45 the hippocampus may contribute to the persistence of fear memories. Copy rights belong to original authors. Visit the link for more info
With the 2020 French Open in the books, Cracked Racquets' Alex Gruskin and Jamie McDonald spent some time putting together an award show to wrap up their coverage of the year's final slam. On this episode, the two give out "The Berdych/Radwanska Award" for holding seed. This episode also aired as a YouTube video, which you can watch by clicking this link. Don’t forget to give a 5 star review with your twitter/instagram handle for a chance to win some FREE CR gear!! This episode brought to you by: DraftKings The French Slam is here! We’ve waited all summer and now we have back to back slams. That means back to back offers thanks to our friends at DraftKings. All new users will get sign up bonus up to $1,000 to bet the clash on clay with your first deposit! Here’s how it works: 1. Create your DraftKings Sportsbook account and make a deposit. 2. DraftKings will match your first deposit at 20% up to $500 3. Make your first bet and DraftKings will also match that with a risk-free first bet up to $500 4. Bet on your favorite Tennis markets throughout the Slam on Clay! Just go to dkng.co/CrackedOpen to play. That’s D-K-N-G DOT C-O SLASH CrackedOpen. Again, act quickly, this offers won’t be around forever. Legal: If you or someone you know has a gambling problem, crisis counseling, and referral services can be accessed by calling 1-800 GAMBLER (1-800-426-2537) (IL) Gambling problem? Call 1-800-GAMBLER (NJ/WV/PA) or 1-800-9-WITH-IT (IN only) or 1-800-BETS-OFF (IA only) or 1-800-522-4700 (CO Only) *21+. NJ/IN/WV/PA/IA/CO/IL only. In partnership with Meadows Racetrack and Casino. Offer not valid for users physically located in NH. Min. $5 Deposit. Deposit bonus is in DK Dollars which have no cash value and must be used on DraftKings. Bonus requires 25x Play-Thru. Eligibility restrictions apply. See draftkings.com/sportsbook for details. Midwest Sports Discounted Tennis Apparel, Tennis Racquets, Tennis Shoes & Equipment from Nike, adidas, Babolat, Wilson & More! Visit their store today and use the code "CR15" at checkout to save 15% off your order!!! Tennis Channel Podcast Network Visit https://www.tennis.com/pro-game/podcasts/ to stay current on the latest tennis news and trends and enjoy in-depth analysis and dynamic debates. Find Cracked Racquets Website: https://www.crackedracquets.com Instagram: https://instagram.com/crackedracquets Twitter: https://twitter.com/crackedracquets Facebook: https://Facebook.com/crackedracquets YouTube: https://www.youtube.com/channel/UC12ZE3jU0n52JkeWV1TB21A Email Newsletter: https://www.crackedracquets.com Learn more about your ad choices. Visit megaphone.fm/adchoices
Rennae sits down with Agnieszka “The Ninja” Radwanska to talk about retirement, her stint on Dancing With the Stars and how growing up in Krakow made one of the greatest shotmakers of all time. See acast.com/privacy for privacy and opt-out information.
Welcome toooo..."Hey, Great Shot!!" On today's episode, Co-Manager of the website "Tennis with an Accent" and author of the book "Novak Djokovic: Making the Rough Places Plain" Matt Zemek joins host Alex Gruskin to talk about the best WTA players of the past decade who didn't win a slam during that time Some of the players included in this first of two parts includes Radwanska, Lisicki, Cibulkova, Jankovic, and Makarova, We'll be continuing the "Best of the Decade" series weekly throughout the remainder of the year, so be sure to check back each week for more content! Don’t forget to give a 5 star review with your twitter/instagram handle for a chance to win some FREE CR gear!! Learn more about your ad choices. Visit megaphone.fm/adchoices
W programie Bartosz Węglarczyk rozmawia z Urszulą Radwańską.
Alexander Zverev has already won a trio of Masters 1000 titles, been ranked as high as No.3, and qualified for the ATP Finals for two straight seasons. He’s a major player in the sport, and promises to be for years to come. We know he isn’t afraid to complain about the length of the season and the content of interview questions, but do we really know what he’s like? To find out more about him, David chats to his long-time friend and colleague Andrej Antic, a German tennis writer who has worked for Tennis MAGAZIN for over two decades. How is Zverev viewed in Germany? Could he create a tennis boom in the country, like during the days of Boris Becker and Steffi Graf? And what is his relationship like with Ivan Lendl? Antic reveals all before discussing his own career. How has his job of producing a magazine changed in the era of social media? On court today, Zverev was beaten by Novak Djokovic. What happened in the match? And are we entering ‘foregone conclusion’ territory with Djokovic this week? In the evening session, Marin Cilic won just his second ever match at the ATP Finals, closing out John Isner in the tournament’s first singles three setter. Bearing in mind his recent lapses when playing with the lead, how important will this win prove to be for Cilic? Finally, there’s a moment to pay tribute to Agnieszka Radwanska who has announced her retirement. How will she be remembered? And did she under-achieve or maximise her potential? The Tennis Podcast is produced weekly in association with Telegraph Sport, and daily at the Grand Slam tournaments. See acast.com/privacy for privacy and opt-out information.
Enlace a Cardiff, con reacciones de Ronaldo. Nota ofensiva del Real Madrid vs defensiva de Juventus. Zidane en Madrid y Juventus. Centrales de Zidane con ambas plantillas. Resumen Mundial Sub 20…Francia vs Italia…USA vs Nueva Zelanda…México vs Senegal. Enlace a Nueva Jersey Reaciones de Cantu. Nota Final NBA que arranca Hoy. Reacciones Ernesto Valverde en su presentacion. NOta Atletico y sancion del TAS.Mencion de la playera. Nota color doctor Who. Reporte SAlida Gulliet Peña. Roland GArros...Murray vs Klizan...Uytvanck vs Radwanska. Centrales de la semana. Fox U
X3. X-Men 3, Xmen III. X-Men colon The Last stand. Whatever it's called it's trivia time. And more Radwanska! Write to us at 4colorflashback@gmail.com Music www.Bensound.com
3 Things you may learn from this week's episode: 1. Cainim does not write fan fiction! 2. John and Karen hate MJ! 3. Cainim is there for you Kirsten Dunst! Today on 4 Color Flashback: Spider-Man 2 The Post Watch! Music by www.bensound.com Who knows? Aunt May? Robbie? MJ? Karen? John? The 3 Moments that made Cainim cry! Cainim's Rant! John Makes a Friends reference! Karen explains banking! And what do My Singing Monsters! Parker Posey! Best In Show! Bones! Vampires!Talk Soup! Community! Queer as Folk! Doctor Who!Lost! Hulk! Daniel Dae Kim! Jeckyl and Hide! Green Goblin! The Soup! Almost Live! Why is Joel McHale stealing Gold Coins? Banking Nerd Humor? First National Coincidence Bank! X-Files! Bruce Campbell! Effie Trinkett! The Simpsons! Kirsten Dunst! Tobey Maguire! Joss Whedon! Rosemary Harris! Indiana Jones. Michael Jackson! Nasonex! Lemony Snickett! JK Simmons! Love interests!Stealing the Presidency! and supergroup Boston!... have to do with Spider-Man 2? Plus: Where did you get married? Bernard! Cainim spells Radwanska! And tries to spell Agnieszka in our Tennis Trivia interlude! All this and Thanks Obama! Peter Pan! Jesus! New York City Science! Doctor Octopus goes shops at Amazon and Ebay?? Super-villain 101! And..John and Karen make Cainim think! Write to us at 4colorflashback@gmail.com Pigeon! Send a Raven! Outline: Pizza Man Peter's not dependable. Parker the sensitive student artiste. Let's check-in on Aunt May, MJ and Harry/Taking Pictures of your friend Pete and MJ in the Alley. Meet Otto the poet and his Yuge amount of energy. The Love song of Peter Benjamin Parker Spider Malfunction Nooooooooooooo! - Science Squid is born Joel McHale-the Jerk Banker at Coincidence Bank. Is this an arranged marriage-Captain Jameson Jazz it up with Zatarans Spider-Man No More. Brand new day How long can Peter look away? About 10 more minutes, Goodnight Bernard. A Kid stuck on the Second floor-wait didn't this happen in Spider-Man? Moving day for Aunt May-Crying time for Cainim That tinkerbell moment. Glasses, who needs glasses? So that's where Harry keeps the Tritium, and the ceremonial dagger. It's a wet costume contest I will always be Spider-Man, Harry the First Avenger, The wedding of the movie. Cringe Cheers Scores Where are they now?(Karen) Byes
It's our second episode of 2017. Here, we're previewing the 2017 Australian Open - keep your draws handy or just listen along to our analysis. Who are our dark horse picks? What are the chances of Serena, Rafa, Angie, Roger, etc? Who do we hope against all odds will have a great showing? 2:00 Jumping right in: Serena’s draw and her first-round opponent 8:00 Looking at the women’s bottom half – Pliskova is Serena’s biggest threat 9:30 Kerber’s chances – women’s top half 12:45 What kind of form is Garbine Muguruza in? 14:45 Elsewhere in the women’s draw: Halep, Konta, Radwanska, Kuznetsova, Venus 19:15 Women’s first round matches to watch 23:30 Men’s draw: Novak Djokovic is #2 seed, faces Verdasco in first round 32:30 The baffling Raonic-Monfils-Nadal-Zverev-RBA quarter 38:00 Men’s top half – Fed/Murray/Nishikori/Berdych share the same quarter 40:30 What are Stan’s chances based on his draw? 43:15 Interesting men’s first rounders 44:30 Jonathan’s dark horse picks 47:15 Our “wish upon a star” picks 51:30 Caroline Wozniacki gets a little mean 54:45 Sharapova and Stuttgart announce Maria’s momentous return, PR continues to be a challenge
We're back to take you through Nick Kyrgios and Maria Sharapova's disciplinary drama. We try to figure out where to stand on Kyrgios, why his behavior angers so many, and what the ATP means by suggesting counselling. As for Sharapova, we are not kind about her tasteless media blitz following her (slightly) reduced suspension. Stick around for actual tennis talk - lauding the strong fall performers and looking ahead to Singapore. 3:00 Kyrgios suspension: warring camps 7:25 Is Nick's perceived apathy the reason so many people are mad? 12:00 What to make of the counselling option? What is the state of mental health in tennis? 21:30 The Swiftian/Trumpesque Media Victory Tour of Maria Sharapova ... where good taste went to die 26:30 James takes you through the details of the Sharapova appeal decision 33:30 Tennis legends invite Maria to WTT charity event, all is forgiven 38:00 Serena's fall swing: Disney World, Color Purple, Formation, NOT Singapore 41:30 Singapore lineup and scenarios 43:00 Big ups to Cibulkova, Wozniacki, Kvitova, Radwanska, Konta, Keys 47:30 Men's fall standouts: Dimitrov, RBA, Murray - can Murray get to no. 1? 51:30 Talking down the Novak slump chatter 54:00 Our faves Venus and Rafa are struggling
Tennis Channel President Ken Solomon talks about how to recruit young talent and reach larger pools of tennis fans. He also discusses how the network is changing after Sinclair Broadcasting bought it. Plus, how the NHL has managed to grab positive headlines after its low-rated Stanley Cup Finals, and what members of the Cleveland Cavaliers staff are doing this summer. All on the latest Keeping Score with Rick Horrow. See acast.com/privacy for privacy and opt-out information.
We're wrapping up just the women's semifinals from Melbourne today (chat on both men's semifinals coming to you tomorrow), and Ben and Courtney are pretty happy with the final we got. Serena was crazy good against Radwanska, and you'll hear about it from *both* coaches involved, Tomasz Wiktorowski and Patrick Mouratoglou. Serena will face Angelique Kerber in the final, so we hear from both Angie and veteran German reporter Doris Henkel about the state of German tennis and other such bossly goodies. Will this final be a good one? We think/hope so. As always, thanks for liking us on Facebook, following us on Twitter, and subscribing/reviewing on whatever your podcasting app/platform of choice may be!
It's the second week, and Ben and Courtney can now talk about lots of important matches as the tournament reaches its pointy end. Gosh, Serena's good, isn't she? Maria's playing well, too, but does it matter? Then, what the heck was all that Djokovic-Simon nonsense? Does the performance cast any doubt over the overwhelming favorite's chances here? And what do the calm and steady performances of Radwanska and Suarez Navarro teach us about veteranliness? Also, stop spitting near Courtney you gross person. As always, thanks for liking us on Facebook, following us on Twitter, and subscribing/reviewing on iTunes or whatever your podcasting platform of choice may be!
1:30 First things first: Justin Bieber is making good songs. What is going on? 5:00 Toronto is winning pop culture right now 7:00 Masculinity and fandom: how men perform gender through watching sports; excluding women from sports fandom 15:00 TV time! Why Jane the Virgin works (especially for James) 19:00 Nashville, Jonathan's non-guilty pleasure 23:30 James Blake on Jon Wertheim's podcast; avoiding the topic of race 31:30 A sort-of tangential discussion of desegregation and racism in Normandy, Missouri (see This American Life's "The Problem We All Live With") 39:00 Talking Singapore 41:00 Does winning the WTA Finals predict a Grand Slam win? 43:00 Radwanska a victim of bad press for winning fair and square 47:00 Fedal is back!!! 54:00 Our hopes for the rest of the season 56:30 Venus: #thankful #blessed #bringiton
As they continue travel schedules that are normally only maintained by Carmen Sandiego characters, Ben and Courtney reconvene from Charlottesville and Zhuhai, respectively, to discuss the happenings of the week in tennis. And what it week it was! Losers got lucky in Singapore, then got good, as Agnieszka Radwanska claimed her biggest career title in unlikely fashion. What does her win say about her, and about the round-robin redemption format? Then, in Switzerland, Roger Federer improved to 5-1 indoors against Rafael Nadal...and still remains his pigeon? We discuss, and then we end by pouring one out for our homies at Grantland. As always, thanks for liking us on Facebook, following us on Twitter, and subscribing/reviewing on iTunes or whatever your podcasting platform of choice may be!
Agnieszka Radwanska is the champion of the 2015 WTA Finals in Singapore, Roger Federer edged Rafael Nadal in the 34th instalment of their rivalry, and Andy Murray has confirmed that he intends to play the ATP World Tour Finals at the 02 Arena. Catherine and David get together to talk it over, and we also hear about a new teenage generation of American players who have a nation expecting. Oh, and Catherine is furious with someone. The Tennis Podcast is produced in association with The Telegraph. See acast.com/privacy for privacy and opt-out information.
Nick Lester's best bets on the #Wimbledon semi-finals
Ben and Courtney are not in Miami, and they have lots of thoughts and concerns about various others that have already made untimely exits from that tournament? What's going on with Maria Sharapova? And is it time to sell stock in Rafael Nadal, or will he turn it around and perform at his best again like always? And what about the bevvy of top 10 players from the WTA in 2014 who are slipping now, like Kerber, Radwanska, Wozniacki, Bouchard, and Ivanovic? Also, why aren't Ben and Courtney in Miami, and why do so few American beat writers make that trip? And why should nobody be complaining about who is there? You can freeload on us all you want, dear listeners, no matter what hobbies you have. As always, thanks for liking us on Facebook, following us on Twitter, and subscribing/reviewing on iTunes or whatever your podcasting platform of choice may be! Related polling/reading/viewing for this week: We'd love it if you filled out our listener feedback survey!
With the women's final fresh in mind and a historic men's final at hand, there's plenty for Steve Tignor and Ed McGrogan to discuss. We recap Serena's win over Radwanska and look ahead to Federer-Murray. Learn more about your ad choices. Visit megaphone.fm/adchoices
Before we get talking about clay, we look back at what happened to Djokovic, Radwanska, Murray, Sharapova, and Nadal at the final hard-court tournament of the spring, Miami. Learn more about your ad choices. Visit megaphone.fm/adchoices
Andy Murray came back from one set down to defeat long-time nemesis Rafael Nadal 3-6, 6-2, 6-0 in the finals of the Rakuten Japan Open Tennis Championships in Tokyo Sunday. Tomas Berdych staged a comeback of his own in the final of the China Open when he beat Marin Cilic 3-6, 6-4, 6-1. Agnieszka Radwanska boosted her chances for qualification to the WTA's year-end championships in Istanbul when she outlasted Andrea Petkovic in three sets in the China Open women's final. This week, the top players try to pick up valuable ranking points at the Masters Series tournament in Shanghai, while Samantha Stosur and Petra Kvitova are the top seeds in Osaka, Japan, and Linz, Austria.