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Each experience may not seem significant on its own; however, these experiences can reveal powerful trends over time. Accumulating your experiences can spark creativity and encourage you to take calculated risks. This conversation challenges you to embrace the learning curve in both business and leadership. You will hear about the faces of regret and how to overcome them, the importance of defining your comfort zone when it comes to risk, and the value of allowing yourself to be inexperienced or even "bad" at something in the early stages of learning. This discussion will guide you in transforming your business strategy: uncover the 'art of magic' in advertising and leadership while breaking free from the constraints of what you should or could have done. In this episode of the BOLD Business Podcast, Jess Dewell engages with Jimi Gibson, the VP of Brand Communication at Thrive Agency. Together, they explore why being new or struggling at something is a crucial step toward achieving greatness through intentional, bold actions and how to maintain a forward-looking perspective when trying new things. -------------------- If you want to identify business bottlenecks, the necessary skills, the initial actions to take, the expected milestones, and the priorities for achieving growth, try the "Growth Framework Reset" approach. This will help you to keep learning and growing while working strategically on your business. -------------------- You can get in touch with Jess Dewell on Twitter, LinkedIn or Red Direction website.
In this episode, we delve into a fascinating correlation Dr Jake and his colleagues are seeing in their practices but also backed by medical research study that explores the correlation between thyroiditis and COVID-19 in both and acute and chronic infection. In the aftermath of the pandemic, we still continue to see it's impact on our our health in various ways. Understanding these connections is crucial for both patients and healthcare professionals so they can heal their bodies and start early, not waiting until problems get worse. Join me as I break down the key findings of the study, discuss its implications, and provide insights into how COVID-19 may affect thyroid health.
Dave Foster, founder of the firm The 1031 Investor, wanted to travel the world in a sailboat and raise his children on the water, and they found a way. He applied the 1031 exchange to his real estate investments, enabling him to move his family to Florida, where he and his wife realized that dream. He leveraged that knowledge to publish “Lifetime Tax-Free Wealth: The Real Estate Investor's Guide to the 1031 Exchange.” (03/2025)
Dave Foster, founder of the firm The 1031 Investor, wanted to travel the world in a sailboat and raise his children on the water, and they found a way. He applied the 1031 exchange to his real estate investments, enabling him to move his family to Florida, where he and his wife realized that dream. He leveraged that knowledge to publish “Lifetime Tax-Free Wealth: The Real Estate Investor's Guide to the 1031 Exchange.” (03/2025)
Dave Foster, founder of the firm The 1031 Investor, wanted to travel the world in a sailboat and raise his children on the water, and they found a way. He applied the 1031 exchange to his real estate investments, enabling him to move his family to Florida, where he and his wife realized that dream. He leveraged that knowledge to publish “Lifetime Tax-Free Wealth: The Real Estate Investor's Guide to the 1031 Exchange.” (03/2025)
Support this podcast at — https://redcircle.com/hypnosis-and-relaxation-sound-therapy9715/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy
The American diet is the leading cause of death among Americans. Accumulating medical evidence now shows that poor diet not only contributes to heart disease, diabetes, and stroke, but also to cancer, Alzheimer's disease, liver disease, and much more. Despite its direct and indirect roles in causing half or more of all deaths, food is not something doctors learn about in their training, nor is it something that's emphasized enough to patients by the medical establishment. Our guest on this episode is Michael Greger, MD, a specialist in lifestyle medicine and one of the most trusted voices in evidence based nutrition and public health. He is the internationally best selling author of How Not to Die (2015), How Not to Diet (2019), and How Not to Age (2023). Over the course of our conversation, Dr. Greger shares his approach to healthy living, focusing on the surprising power of whole-food, largely plant-based diets in transforming our bodies at a molecular level. He discusses strategies for helping patients and ourselves achieve behavioral change and explores how our brains and palates are rewired by processed foods, how we can reverse this, the ethics of patient counseling around lifestyle interventions, why there is such a mismatch between nutrition beliefs and behaviors among physicians, and his most high-yield recommendations for starting your journey to eating well.In this episode, you'll hear about: 2:45 - How Dr. Greger's grandmother's miraculous recovery due to diet change inspired him to build a career in nutrition science6:58 - The disconnect that exists between the American medical system and the science of nutrition 13:57 - Why nutrition education is lacking in American medical training 21:31 - Issues with compliance among patients trying to adopt a lifestyle of healthy eating28:00 - Supporting patients who are not interested in preventative healthcare measures 35:15 - Navigating the confusing and often conflicting landscape of nutritional studies 43:20 - Whether there is a universal dietary recommendation46:49 - Simple ways to improve your diet, starting todayVisit our website www.TheDoctorsArt.com where you can find transcripts of all episodes.If you enjoyed this episode, please subscribe, rate, and review our show, available for free on Spotify, Apple Podcasts, or wherever you get your podcasts. If you know of a doctor, patient, or anyone working in health care who would love to explore meaning in medicine with us on the show, feel free to leave a suggestion in the comments or send an email to info@thedoctorsart.com.Copyright The Doctor's Art Podcast 2024
By Lincoln Marini - People who hear this message will learn about God's incentive plan established in the Garden of Eden and understand the importance of doing all the same works Jesus did.
Today's guest is Martin Fowler! Martin is chief scientist at ThoughtWorks. He is one of the original signatories of the Agile Manifesto and author of several legendary books, among which there is Refactoring, which shares the name with this podcast and this newsletter. With Martin, we talked about the impact of AI on software development, from the development process to how human learning and understanding changes up to the future of software engineering jobs. Then we explored the technical debt metaphor, why it has been so successful, and Martin's own advice on dealing with it. And finally, we talked about the state of Agile, the resistance that still exists today towards many Agile practices and how to measure engineering effectiveness. (03:29) Introduction (05:20) Development cycle with AI (08:36) Less control and reduced learning (13:11) Splitting task between Human and AI (14:48) The skills shift (20:17) Betting on new technologies (27:22) Martin's Refactoring and technical debt (29:24) Accumulating "cruft" (33:14) Dealing with "cruft" (37:24) The financial value of refactoring (42:04) Measuring performances (46:19) Why the "forest" didn't spread (56:11) Make the forest appealing — This episode is brought to you by https://workos.com — You can also find this at: -
PODCAST : WOMEN'S DISCONTENTMENT WILL END THE WORLD. TOPICS:Challenges of Eros in long-term relationships.The correct purpose of a long-term partnership.Dropping birth rates.Adversity as the source of meaning.Accumulating experiences of betrayal in hook-up culture.The chronic dissatisfaction of the modern woman.Men want to make women happy; modern woman has vowed to not be happy.For most women, submission is weakness.Women's submissions as men's reward and fuel.Ownership in relationships.It's not a man's job to bring a woman into submission.Attitude towards naysayers.Women's fantasies.BDSM in long-term relationships.Your Permission Field in a relationship.Men's path to dominance.Real sexual mastery.Casual sex vs. partnership.Women's sex and self-worth.Women can't submit to a man they don't respect.Money beliefs in family lineage.Healthy dynamic between mother and son.Masculinity in media.Feminism's efficiency in destroying man-woman relationships.Relationship mastery as prerequisite to sexual connection.Too many men these days are boring.-- Om Rupaniwww.OmRupani.org
The snow shovel may need to come out as fresh snow is in the forecast.
In this podcast episode, Dr. Jonathan H. Westover talks with Ajay Malik about the common misconceptions or challenges that businesses face when incorporating AI into their workflows. Ajay Malik is a visionary leader renowned for delivering cutting-edge technology products. Boasting a track record of successful execution, he prioritizes user-centric solutions and has formed top-tier teams. Accumulating over 90 patents, Ajay stands out as an innovator. As the author of "RTLS for Dummies" and "Artificial Intelligence for Wireless Networking," he showcases expertise in real-time location systems and AI-driven wireless networking. Ajay spearheads Secomind, a progressive company seamlessly integrating AI into products and workflows through the StudioX platform. StudioX offers tailored AI applications, positioning businesses at the forefront of their industries. Check out all of the podcasts in the HCI Podcast Network!
Accumulating snow from a Midwest clipper storm is on the move and has eyes for the Northeast prior to the end of the week. And, in some areas, a coastal storm will join in and expand wintry travel problems. And what exactly is a clipper storm? Learn more about your ad choices. Visit podcastchoices.com/adchoices
Time stamps:00:02 - Leg extensions debated as quad exercise03:26 - Comfort as a variable in exercise choice05:29 - Coordination demands in leg exercises08:00 - Importance of stability in exercises10:36 - Beginners vs advanced trainees in training15:57 - Diminishing returns in muscle growth factors18:10 - Stability improves hypertrophy outcomes20:12 - Load magnitude affects exercise stability23:05 - Bodybuilders prefer machines for effectiveness24:36 - Optimal protein intake recommendations27:30 - Beginners need fewer sets to grow30:55 - More training leads to diminishing returns33:31 - Overcoming sleep issues in training36:06 - Identifying the weakest link in progress39:44 - Synergy between training, nutrition, and recovery41:58 - Importance of addressing exercise constraints43:50 - Fixing dumbbell press asymmetry issues46:57 - Stability and comfort as exercise priorities49:44 - Accumulating volume for better results52:25 - Importance of context in exercise advice55:57 - Adapting exercises for better experiences1:00:02 - Importance of orthopedic health in training1:03:26 - Adjustability in machines enhances sustainability1:06:42 - Rethinking the use of machines in workouts
Time stamps:00:02 - Leg extensions debated as quad exercise03:26 - Comfort as a variable in exercise choice05:29 - Coordination demands in leg exercises08:00 - Importance of stability in exercises10:36 - Beginners vs advanced trainees in training15:57 - Diminishing returns in muscle growth factors18:10 - Stability improves hypertrophy outcomes20:12 - Load magnitude affects exercise stability23:05 - Bodybuilders prefer machines for effectiveness24:36 - Optimal protein intake recommendations27:30 - Beginners need fewer sets to grow30:55 - More training leads to diminishing returns33:31 - Overcoming sleep issues in training36:06 - Identifying the weakest link in progress39:44 - Synergy between training, nutrition, and recovery41:58 - Importance of addressing exercise constraints43:50 - Fixing dumbbell press asymmetry issues46:57 - Stability and comfort as exercise priorities49:44 - Accumulating volume for better results52:25 - Importance of context in exercise advice55:57 - Adapting exercises for better experiences1:00:02 - Importance of orthopedic health in training1:03:26 - Adjustability in machines enhances sustainability1:06:42 - Rethinking the use of machines in workouts
In the latest RPGBOT.Podcast we dive deep into lingering injuries in TTRPGs, exploring how they enhance character development and gameplay comparing injury systems across D&D 5E, Pathfinder, Star Wars RPG, Vaesen, Warhammer 40k, and more! Whether you're a GM or a player, this episode is packed with ideas for adding depth and consequence to your games. Episode Summary In this episode, the RPGBOT.Podcast hosts engage in a reflective and insightful discussion on two key topics. First, they address past comments made about the OSR (Old-School Renaissance) community, acknowledging missteps and celebrating the positive progress within the community. This segment sets the stage for a deep dive into injury systems across various tabletop role-playing games (TTRPGs). The hosts explore how lingering injuries add depth, consequences, and narrative weight to TTRPGs. Drawing comparisons across multiple systems—including D&D 5E, Tales of the Valiant, Pathfinder 1st Edition, Fantasy Flight's Star Wars RPG, Imperium Maledictum, and Vaesen—the episode offers a comprehensive look at how injuries are implemented, their impact on gameplay, and how to homebrew these mechanics to enhance immersion. Key Discussion Points Reflecting on the OSR Community Acknowledging and learning from past comments. Highlighting positive strides in inclusivity and creativity within the OSR space. Lingering Injuries in TTRPGs Exploring the narrative and mechanical value of injury systems. Examining how injuries can influence character development and roleplay depth. The importance of tailoring injury mechanics through homebrewing. System Spotlights: Injury Mechanics D&D 5E and Tales of the Valiant Discussing strengths and limitations of injury mechanics in these systems. Suggestions for homebrewed injury rules to increase immersion. Pathfinder 1st Edition Delving into critical hits and the brutal consequences for characters. Evaluating how the system balances risk and reward. Fantasy Flight's Star Wars RPG Analyzing its unique injury system and comparing it to Pathfinder. Highlighting the narrative flavor of lingering injuries in Star Wars settings. Imperium Maledictum (Warhammer 40k) Examining the grim nature of injuries and high character mortality rates. How injuries contribute to the dark, oppressive atmosphere of Warhammer 40k. Vaesen Exploring how physical and mental injuries are treated equally. Understanding defects and insights as gameplay mechanics. Comparing Vaesen's system to others and identifying its strengths and weaknesses. Narrative and Gameplay Impact of Injuries How injury systems enhance storytelling and player immersion. Balancing mechanics and narrative to avoid punishing players unfairly. The hosts reflect on the versatility and potential of injury systems in TTRPGs to create meaningful, memorable gameplay moments. They also emphasize the importance of community dialogue and mutual understanding to foster growth within the tabletop gaming community. Resources Mentioned D&D 5E Tales of the Valiant Pathfinder 1st Edition Fantasy Flight's Star Wars RPG Imperium Maledictum (Warhammer 40k) Vaesen Want to Join in on the Discussion? What injury systems have you used in your games? Join the conversation by sharing your experiences and homebrew rules on social media or our website. Links below. Links Call of Cthulhu (affiliate link) Edge of the Empire (affiliate link) Genesys (affiliate link) Imperium Maledictum (affiliate link) Tales of the Valiant Game Master's Guide (affiliate link) RPGBOT.Podcast Episodes Variant Rules Medicine Episode Takeaways Thematic and Narrative Depth Lingering injuries can create a more threatening and immersive atmosphere in TTRPGs. Injuries enhance storytelling by introducing consequences that impact character arcs. Injury mechanics can lead to compelling story elements, such as finding a high-level wizard or integrating prosthetics in grim settings like Warhammer 40k. Mechanical Implications of Injuries Injuries should have tangible mechanical impacts beyond reducing hit points, addressing the arbitrariness of HP systems. Systems like Tales of the Valiant and Pathfinder 1 demonstrate how injuries can influence gameplay, from critical hits to debilitating conditions like Con Drain. Intelligence bleed and other mechanics can deeply affect a character's abilities and decision-making. Homebrewing and Session Zero Homebrewing injury systems can add depth and immersion, tailoring gameplay to group preferences. Discussing injury mechanics during session zero ensures clarity and sets expectations for how they'll impact the campaign. System Highlights and Comparisons Pathfinder 1: The critical hit deck introduces brutal, game-changing effects. Fantasy Flight Star Wars: A unique injury system creates tension, with critical injuries leading to severe consequences. Imperium Maledictum: Highlights character fragility and permanent changes in the Warhammer 40k universe. Vaesen: Balances physical and mental injuries, introducing defects (GM-driven challenges) and insights (player-driven advantages) that affect gameplay. Player Agency and Risk Management Injury systems work best when integrated into core mechanics, balancing risk and reward. Players can strategically leverage mechanics like insights in Vaesen for maximum effect, creating dynamic gameplay moments. Campaign Considerations Starting at higher levels can mitigate the harshness of injuries early in a campaign. Accumulating defects or lingering effects can foster interesting character development and party dynamics. Game Design and Immersion A well-designed injury system enhances both gameplay and immersion, reflecting the stakes of adventuring. Comparative analysis of systems reveals diverse approaches to integrating injury mechanics, showing the breadth of possibilities in RPG design. If you enjoy the show, please rate and review us on Apple Podcasts, Spotify, or your favorite podcast app. It's a quick, free way to support the podcast, and helps us reach new listeners. If you love the show, consider joining us on Patreon, where backers at the $5 and above tiers get ad free access to RPGBOT.net and the RPGBOT.Podcast, can chat directly to members of the RPGBOT team and community on the RPGBOT.Discord, and can join us for live-streamed recordings. Support us on Amazon.com when you purchase products recommended in the show at the following link: https://amzn.to/3NwElxQ How to Find Us: In-depth articles, guides, handbooks, reviews, news on Tabletop Role Playing at RPGBOT.net Tyler Kamstra Twitter: @RPGBOTDOTNET Facebook: rpgbotbotdotnet Bluesky:rpgbot.bsky.social Ash Ely Professional Game Master on StartPlaying.Games Twitter: @GravenAshes YouTube@ashravenmedia Randall James @JackAmateur Amateurjack.com Producer Dan @Lzr_illuminati
In the latest RPGBOT.Podcast we dive deep into lingering injuries in TTRPGs, exploring how they enhance character development and gameplay comparing injury systems across D&D 5E, Pathfinder, Star Wars RPG, Vaesen, Warhammer 40k, and more! Whether you're a GM or a player, this episode is packed with ideas for adding depth and consequence to your games. Episode Summary In this episode, the RPGBOT.Podcast hosts engage in a reflective and insightful discussion on two key topics. First, they address past comments made about the OSR (Old-School Renaissance) community, acknowledging missteps and celebrating the positive progress within the community. This segment sets the stage for a deep dive into injury systems across various tabletop role-playing games (TTRPGs). The hosts explore how lingering injuries add depth, consequences, and narrative weight to TTRPGs. Drawing comparisons across multiple systems—including D&D 5E, Tales of the Valiant, Pathfinder 1st Edition, Fantasy Flight's Star Wars RPG, Imperium Maledictum, and Vaesen—the episode offers a comprehensive look at how injuries are implemented, their impact on gameplay, and how to homebrew these mechanics to enhance immersion. Key Discussion Points Reflecting on the OSR Community Acknowledging and learning from past comments. Highlighting positive strides in inclusivity and creativity within the OSR space. Lingering Injuries in TTRPGs Exploring the narrative and mechanical value of injury systems. Examining how injuries can influence character development and roleplay depth. The importance of tailoring injury mechanics through homebrewing. System Spotlights: Injury Mechanics D&D 5E and Tales of the Valiant Discussing strengths and limitations of injury mechanics in these systems. Suggestions for homebrewed injury rules to increase immersion. Pathfinder 1st Edition Delving into critical hits and the brutal consequences for characters. Evaluating how the system balances risk and reward. Fantasy Flight's Star Wars RPG Analyzing its unique injury system and comparing it to Pathfinder. Highlighting the narrative flavor of lingering injuries in Star Wars settings. Imperium Maledictum (Warhammer 40k) Examining the grim nature of injuries and high character mortality rates. How injuries contribute to the dark, oppressive atmosphere of Warhammer 40k. Vaesen Exploring how physical and mental injuries are treated equally. Understanding defects and insights as gameplay mechanics. Comparing Vaesen's system to others and identifying its strengths and weaknesses. Narrative and Gameplay Impact of Injuries How injury systems enhance storytelling and player immersion. Balancing mechanics and narrative to avoid punishing players unfairly. The hosts reflect on the versatility and potential of injury systems in TTRPGs to create meaningful, memorable gameplay moments. They also emphasize the importance of community dialogue and mutual understanding to foster growth within the tabletop gaming community. Resources Mentioned D&D 5E Tales of the Valiant Pathfinder 1st Edition Fantasy Flight's Star Wars RPG Imperium Maledictum (Warhammer 40k) Vaesen Want to Join in on the Discussion? What injury systems have you used in your games? Join the conversation by sharing your experiences and homebrew rules on social media or our website. Links below. Links Call of Cthulhu (affiliate link) Edge of the Empire (affiliate link) Genesys (affiliate link) Imperium Maledictum (affiliate link) Tales of the Valiant Game Master's Guide (affiliate link) RPGBOT.Podcast Episodes Variant Rules Medicine Episode Takeaways Thematic and Narrative Depth Lingering injuries can create a more threatening and immersive atmosphere in TTRPGs. Injuries enhance storytelling by introducing consequences that impact character arcs. Injury mechanics can lead to compelling story elements, such as finding a high-level wizard or integrating prosthetics in grim settings like Warhammer 40k. Mechanical Implications of Injuries Injuries should have tangible mechanical impacts beyond reducing hit points, addressing the arbitrariness of HP systems. Systems like Tales of the Valiant and Pathfinder 1 demonstrate how injuries can influence gameplay, from critical hits to debilitating conditions like Con Drain. Intelligence bleed and other mechanics can deeply affect a character's abilities and decision-making. Homebrewing and Session Zero Homebrewing injury systems can add depth and immersion, tailoring gameplay to group preferences. Discussing injury mechanics during session zero ensures clarity and sets expectations for how they'll impact the campaign. System Highlights and Comparisons Pathfinder 1: The critical hit deck introduces brutal, game-changing effects. Fantasy Flight Star Wars: A unique injury system creates tension, with critical injuries leading to severe consequences. Imperium Maledictum: Highlights character fragility and permanent changes in the Warhammer 40k universe. Vaesen: Balances physical and mental injuries, introducing defects (GM-driven challenges) and insights (player-driven advantages) that affect gameplay. Player Agency and Risk Management Injury systems work best when integrated into core mechanics, balancing risk and reward. Players can strategically leverage mechanics like insights in Vaesen for maximum effect, creating dynamic gameplay moments. Campaign Considerations Starting at higher levels can mitigate the harshness of injuries early in a campaign. Accumulating defects or lingering effects can foster interesting character development and party dynamics. Game Design and Immersion A well-designed injury system enhances both gameplay and immersion, reflecting the stakes of adventuring. Comparative analysis of systems reveals diverse approaches to integrating injury mechanics, showing the breadth of possibilities in RPG design. If you enjoy the show, please rate and review us on Apple Podcasts, Spotify, or your favorite podcast app. It's a quick, free way to support the podcast, and helps us reach new listeners. If you love the show, consider joining us on Patreon, where backers at the $5 and above tiers get ad free access to RPGBOT.net and the RPGBOT.Podcast, can chat directly to members of the RPGBOT team and community on the RPGBOT.Discord, and can join us for live-streamed recordings. Support us on Amazon.com when you purchase products recommended in the show at the following link: https://amzn.to/3NwElxQ How to Find Us: In-depth articles, guides, handbooks, reviews, news on Tabletop Role Playing at RPGBOT.net Tyler Kamstra Twitter: @RPGBOTDOTNET Facebook: rpgbotbotdotnet Bluesky:rpgbot.bsky.social Ash Ely Professional Game Master on StartPlaying.Games Twitter: @GravenAshes YouTube@ashravenmedia Randall James @JackAmateur Amateurjack.com Producer Dan @Lzr_illuminati
Selling assets too soon could be your biggest financial mistake, and Tom Krol is here to explain why…In this episode, learn how to make cash flow grow your net worth, not your expenses, and why tracking your net worth weekly is a game changer for long-term success. Start building your wealth today with Brent's TTP training program! ---------Show notes:(0:50) Beginning of today's episode(1:50) Your largest financial loss came from selling assets(13:15) It's not just cashflow, it's cashflow + net worth(13:55) Make sure your cash flow increases your net worth before it increases your living expenses(17:59) Know what your net worth is, measure it every week and set a goal (18:43) Assets - Liabilities = Net Worth----------Resources:Profit First by Mike MichalowiczRich Dad Poor Dad by Robert KiyosakiCashflow Quadrant by Robert KiyosakiFollow Tom Krol hereCoaching Inc.To speak with Brent or one of our other expert coaches call (281) 835-4201 or schedule your free discovery call here to learn about our mentorship programs and become part of the TribeGo to Wholesalingincgroup.com to become part of one of the fastest growing Facebook communities in the Wholesaling space. Get all of your burning Wholesaling questions answered, gain access to JV partnerships, and connect with other "success minded" Rhinos in the community.It's 100% free to join. The opportunities in this community are endless, what are you waiting for?
Crypto Town Hall is a daily X Spaces hosted by Scott Melker, Ran Neuner & Mario Nawfal. Every day we discuss the latest news in crypto and bring the biggest names in the space to share their insight. ►►TRADING ALPHA READY TO TRADE LIKE THE PROS? THE BEST TRADERS IN CRYPTO ARE RELYING ON THESE INDICATORS TO MAKE TRADES. USE CODE ‘2MONTHSOFF' WHEN VISITING MY LINK.
KIRO Newsradio caught up with a Seattle resident known for taking very long walks right here at home, seeing the city and the region from a unique perspective – and then sharing it with others through photos and tours. Austin Watson retired after a long career at Boeing, and he now lives with his wife in Downtown Seattle. He wears comfortable clothes and serious walking shoes because on a good day – which means pretty much every day – he’ll easily cover 10 miles on foot. He also owns decent rain gear, because he’ll often take his long walks rain or shine – which is something of a given in the Pacific Northwest.
Sean Brodrick, Editor of Wealth Megatrends and contributing analyst to Weiss Ratings Daily, joins us to outline the various opportunities that he is seeing in the junior mining stocks, as gold, silver, and uranium keep moving higher. We unpack some of the fundamental drivers in the precious metals, but then discuss the opportunities he sees in the mid to small junior gold and silver producers and developers; and why he is still steering clear of the earlier stage exploration stock. Sean also points out that he is even more animated with the opportunities presenting investors in the silver stocks over the gold stocks, and what type of silver stocks he is most interested in. Wrapping up we discuss the big rebound we've seen in the uranium stocks during the month of September, after a few rough corrective months prior to that, and why he is still longer-term bullish on the whole uranium sector. Click here to follow along with Sean's work at Weiss Ratings Daily and Wealth Megatrends Click here to learn more about Resource Trader
In this episode of the School of Healing, host Dominiece Clifton interviews Chelsea Holden, a spiritual life coach and business mentor. They explore their shared interests in business and spirituality, with Chelsea emphasizing the importance of self-discovery, taking action, and building supportive communities in entrepreneurship. Chelsea discusses her transition from realtor to coach, her experience as a caregiver for her sister with special needs, and the lessons learned about resilience and nervous system regulation. They also delve into the common habit of accumulating knowledge without applying it and the necessity of finding personal alignment in one's journey.Key Takeaways From This Episode:Slow, mindful starts in the morning set the tone for the day and help maintain focus.Prioritizing action over mere knowledge accumulation is crucial for progress and growth.Building a supportive community provides essential encouragement and collaboration.Faith and spirituality offer resilience and a sense of purpose in entrepreneurship.Fire Soundbites You Don't Want To Miss!"You have to start with yourself and you've got to have that foundation.""Accumulating knowledge without action is a form of procrastination.""We all bring our own unique flavor to everything that we do."Connect With Chelsea Holden:Join Chelsea for the Breakthrough Challenge in September 2024Website: chelseaholden.comInstagram: @thechelseaholdenLearn more about Chelsea's Soulful Entrepreneur TransformationSupport the showIMPORTANT LINKS AND RESOURCES: Book a Free DISCOVERY CALL To Learn More About 1:1 Business Coaching With Dom Learn more about MOVE AND STILL'S service offerings CONNECT WITH DOM: Learn about my 12-week biz coaching program for women entrepreneurs IG - @DominieceRClifton LI- Dominiece R. Clifton Email: hello@movexstill.com A GIFT FOR YOU! Don't forget to subscribe, rate, and review the show on Apple Podcasts to be entered into a drawing to receive my new book FREE! I will be picking one winner monthly. Just send me the screenshot at hello@movestill.com to enter.
There comes a stage in training where week-to-week progress grinds to a halt, and it is often met with feeling like you have regressed or are stuck. You can even stretch this timeline out, and it might feel like noticeable progress doesn't happen for months. This can be a difficult realisation to overcome, and it is a constant battle that challenges many athletes and coaches. But progress doesn't have to be measured by adding more weight to the bar or knocking off seconds on your interval split times. A lot of CrossFit is about maintaining your abilities under more duress and fatigue. In this episode, we discuss some other, more discreet ways to measure progress and see if an athlete is improving. We talk about how this applies to different training modalities and how we can harness it to help motivate athletes, along with some other thoughts and ideas about programming. If you're not already subscribed to our newsletter, head over to www.legionsc.com to get a weekly selection of training tips and our favorite articles. We run online workshops for coaches as well. Find out when our next workshop is here: https://legionsc.com/program-design-workshops These podcasts are posted in video format on YouTube as well. Show Notes: [2:30] The goal of training is to create adaptation [4:30] Alternative and discreet measures of progress [6:00] Progress happens under the curve [8:45] Athlete confidence or progress? [10:00] Tricking athletes with different styles of programming [11:30] Accumulating work as a form of improvement [13:30] Making your performance more durable [14:45] Durability of gymnastics skills [17:00] Being flexible with gymnastics programming
A @Christadelphians Video: 4. Trust in money to get more possessions leaves no time for God. In His mercy, our Father chooses individuals to join His family. ### Highlights - The challenge of serving God vs. materialism is especially relevant for younger generations.
The Lancet Psychiatry Commission on youth mental health
Welcome back to our ongoing series exploring the developer journey! Today, we're diving into a topic that affects every coder's life: digital clutter. As developers, we often start our careers bright-eyed and eager, only to find ourselves buried under mountains of code, tabs, and digital debris years later. Clutter can significantly impede our productivity and creativity, whether in our codebases or desktops. This episode will explore practical strategies for decluttering your digital life, from cleaning messy code to organizing your workspace. We'll share real-world examples of clutter nightmares and provide actionable tips to help you streamline your development process. Whether you're a seasoned developer drowning in legacy code or a newcomer looking to establish good habits early, this episode is for you. Let's dive in and learn how to cut through the digital noise, allowing us to focus on what truly matters - writing great code and building amazing software. Decluttering Your Codebase: Tackling the Silent Productivity Killer One of the most insidious forms of clutter in a developer's life is code clutter. Rob shares a nightmarish example of a project that had evolved over the years, accumulating layers of outdated code, half-implemented features, and confusing version control practices. This scenario is all too common and highlights the importance of maintaining clean, organized codebases. Key takeaways for decluttering your code: Don't be afraid to delete unused code. Version control systems like Git allow you to recover old code if needed. Avoid excessive commenting out of code. If you must save snippets, store them in separate files. Use proper version control practices. Avoid naming files with version numbers (e.g., index1.html, index2.html). Implement a .gitignore file to prevent unnecessary files from cluttering your repository. Keep sensitive information out of your codebase, especially if it's publicly accessible. Michael also emphasized the importance of code reviews and static analysis tools like SonarQube for identifying and removing dead code. Decluttering Through Smart Coding: Avoiding Copy-Paste Syndrome Another primary source of code clutter is copying and pasting code across multiple locations. This practice leads to maintenance nightmares and makes debugging exponentially more difficult. Instead: Create utility functions or classes for reusable code. Consider creating parent classes or standalone modules for shared functionality. Break down long methods into smaller, more focused functions. By following these practices, you'll create more maintainable and easier-to-understand code. Decluttering Your Digital Workspace The conversation then shifted to the broader issue of digital clutter in our daily lives. Two major culprits were identified: Browser tab overload: Having countless tabs open can slow down your machine and make it difficult to find the information you need. Desktop/smartphone app clutter: A disorganized array of icons on your desktop or pages of apps on your phone can waste time and increase frustration. To combat these issues, we suggest the following: Organizing apps and files into logical folders or categories. Regularly closing unnecessary browser tabs and applications. Implementing a "clean desk" policy, both digitally and physically, is especially important for those working with sensitive information. Decluttering Through Daily Shutdowns An interesting point raised was the lost practice of shutting down our computers at the end of each workday. With modern machines capable of running for extended periods, we've developed the habit of leaving everything open indefinitely. However, there's value in closing applications and rebooting regularly: It forces you to organize and save your work. It provides a clear break between workdays. It can improve system performance and stability. Decluttering Your Data: Managing Test and Production Environments Finally, we ended with a discussion on data clutter, particularly in development and testing environments. Accumulating test data can slow down systems and complicate debugging. For example: Writing cleanup scripts to remove test data after use. Implementing data archiving strategies for production systems. Consider data lifecycle management as part of your overall development process. Embracing a Decluttered Developer Life While initially daunting, decluttering your digital life can become addictive once you experience the benefits. The time invested in organizing your code, cleaning up your digital workspace, and managing your data pays dividends in increased productivity and reduced stress. As developers, our work lives are intrinsically tied to the digital realm. By taking control of our digital environments and cultivating habits that promote organization and cleanliness, we become more efficient coders and create a more enjoyable and less stressful work experience. So, take a moment to assess your digital clutter – your future self will thank you. Stay Connected: Join the Developreneur Community We invite you to join our community and share your coding journey with us. Whether you're a seasoned developer or just starting, there's always room to learn and grow together. Contact us at info@develpreneur.com with your questions, feedback, or suggestions for future episodes. Together, let's continue exploring the exciting world of software development. Additional Resources Balance Your Time in a Busy World: Tools and Techniques Boost Your Developer Efficiency: Automation Tips for Developers Code Refactoring: Maintaining Clean, Efficient Code Cleaning Your Task List The Developer Journey Videos – With Bonus Content
In this episode, Brian Brookshire provides a comprehensive analysis of MicroStrategy's bitcoin acquisition strategy. He begins with his background in fintech product marketing, including experiences at Stanford and in Asia. Brian explores MicroStrategy's use of convertible debt to accumulate more bitcoin per share, evaluating the marginal returns and looking back at the NAV discount in 2022. He discusses the risks of MicroStrategy as a bitcoin yield vehicle, potential new products, and future acquisitions. The conversation compares spot bitcoin to spot MSTR and considers whether other companies will soon follow MicroStrategy's lead. Last, Brian dives into his perspective on the stock-to-flow and power law models.SUPPORT THE PODCAST:→ Subscribe→ Leave a review→ Share the show out with your friends and family→ Send us an email podcast@unchained.comTIMESTAMPS:00:00:00 Intro00:01:11 Brian's background—Stanford, Asia, and fintech product marketing00:02:49 MSTR's bitcoin convertible debt strategy00:12:08 Accumulating more bitcoin per share00:15:26 Marginal returns on increasing bitcoin per share?00:18:27 MSTR's NAV blowing out?00:19:41 MSTR's NAV discount in 202200:21:50 MSTR as bitcoin yield?00:22:48 MSTR new products and potential future acquisitions00:24:12 Spot bitcoin vs spot MSTR00:25:49 Will other companies finally follow MSTR?00:30:08 S2F, power law, and the models00:32:00 What's the biggest risk to bitcoin?00:34:44 What's something you believe about bitcoin that many bitcoiners would disagree with?00:35:26 Closing thoughtsWHERE TO FOLLOW US:→ Unchained Twitter: https://twitter.com/unchainedcom→ Unchained Linkedin: https://www.linkedin.com/company/unchainedcom → Unchained Newsletter: https://unchained.com/newsletter → Joe Burnett's Twitter: https://twitter.com/IIICapital→ Brian Brookshire's Twitter: https://x.com/btc_overflow
With the uptick in popularity of ultra running, Doc Lyss sits down and shares with y'all what you want to look for in your running program, recommended minimum mileage, building off your base, setting realistic timelines, and MORE!
Accumulating clutter in your life is some much easier than clearing it! Join us on this episode as we delve into a powerful conversation with Janet M. Taylor founder of Organize Your Life with Janet Taylor. Please connect with Janet to support all of the amazing thing she's doing in the world. Reach out via her website: https://www.janettaylor.com STAY TUNED, and SHARE The Love Drops Podcast with everyone you know!!!! Also follow Love Drops Podcast on AMAZON and we invite you to leave a review.... https://music.amazon.com/podcasts/a13685c0-11e3-45f7-b017-27dc85864f5b/love-drops https://envisionedbroadcasting.com/love-drops Shout Out to Maritri Garrett (No Regrets) our opening and closing song! Connect with and support Maritri's Music here on "The Soulfolk Experience" website https://www.soulfolkexperience.com/home Check out Maritri https://www.instagram.com/maritrimusic https://www.facebook.com/maritri https://youtu.be/ZsoethQupfg Love Drops Podcast is changing the world one love drop at a time! We invite you to check out the Share Love page on Paths2transformation.com (P2T) and Invest in the Journey by sharing love with your resources and word of mouth! Thanks for your support; There is No "US" without "U" ~One Love #TheBestisYetToCome! HTTPS://WWW.PATHS2TRANSFORMATION.COM
The guys suffer through Happy's dog farts while they discuss how Justin and Kate ate rancid meat and lived to tell the tale, then Christian recounts how he said something awkwardly sexual in the presence of some manly bros. We read a letter from Courtney about that one time Justin touched her shoulder after Seminar on Broadway, plus she offers a WYR about whether they'd want to receive a compliment a day or a bit of helpful feedback a day. Finally, we hear a voicemail from Zaira full of compliments and a WYR about having long toe nails vs finger nails. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Recently, a series of papers were published in Nature and Nature journals illuminating the physiologic effects of exercise from an NIH initiative called MoTrPAC. To understand the wealth of new findings, I spoke with Professor Euan Ashley, who, along with Matt Wheeler, heads up the bioinformatics center.Earlier this week, Stanford announced Evan Ashley will be the new Chair of the Department of Medicine. He has done groundbreaking work in human genomics, including rapid whole genome sequencing for critically ill patients and applying the technology for people with unknown diseases. A few years ago he published The Genome Odyssey book. As you'll see from our conversation, he has also done extensive work on the science of exercise.Video snippet from our conversation. Full videos of all Ground Truths podcasts can be seen on YouTube here. The audios are also available on Apple and Spotify.Transcript with audio and external linksEric Topol (00:06):Well, hello, it's Eric Topol with Ground Truths, and I'm really delighted today to welcome my friend, Euan Ashley. He is the Roger and Joelle Burnell Chair of Genomics and Precision Health at Stanford. He's done pioneering work in genomics, but today we're going to talk about something very different, which he also is working in exercise. Exercise the cover of a Nature paper in May regarding this MoTrPAC, which we're going to talk about this big initiative to understand the benefits of exercise. But before I hand it over to Euan, and I just want to mention his description of the paper that he posted to summarize started with, “Exercise may be the single most potent medical intervention ever known.” So Euan welcome.Euan Ashley (01:01):Yeah, well, great. It's wonderful to be here, Eric, and so nice to see you.Eric Topol (01:06):Yeah. Well, we have a lot to talk about because exercise is a fascinating topic. And I guess maybe we'd start with the MoTrPAC, which is an interesting acronym that you all came up with. Maybe tell us a bit about that with the 800 rats and the 2,400 people and the 17,000 molecules, there's a lot there.Euan Ashley (01:24):Right, right. Yeah. Well, first of all, of course, before you do any scientific study, especially with a large number of people in a consortium, you need a good acronym. So that was where we started with the idea was to focus on the molecular transducers of physical activity. As you pointed out there at the beginning, we really don't have a more potent medical intervention, especially for prevention of disease. I mean, it's just such a powerful thing that we have, and yet we don't really understand how it works. And so, the MoTrPAC Consortium was designed to really work together, bring groups of people across the US together who all have some interest in exercise and some ability to measure molecules and really put together the world's largest study of exercise to try and start answering some of the questions about where the potency of this intervention come from.Eric Topol (02:20):So the first crop of papers, and there were several of them that came out all on the same day in Nature publications, was about the rats. The people part is incubating, but can you give us a skinny on, there was a lot there, but maybe you could just summarize what you thought were the main findings.Key MoTrPAC FindingsEuan Ashley (02:43):Yeah, of course, of course. And the MoTrPAC Consortium, I'll say first of all, yeah, large group is probably I think 36 principal investigators funded by the Common Fund. And so, it brings together large numbers of people, some of whom who spend most of their time thinking about let's say animal exercise. Some have spent a lot of time thinking about humans in exercise and many of whom think about measuring technologies. And as you say, these first group of papers were focused on the rat study, but actually the study goes much more broadly than that. But of course, there are some advantages to the animal protocols. We can look at tissue and we'll talk about that in a moment. But the humans, of course, are where we're most interested in the end. And we do have tissues coming from humans blood and adipose tissue and skeletal muscle, but those are obviously the only organs we can really access.(03:31):So there's a rat study, which is this one we'll talk about, and that's aerobic exercise and training. There's human studies that include aerobic exercise, strengths studies as well. There's a study in kids, pediatric study and then also a study of people who are very fit because here we're focusing on the change from sedentary to fit. And so that gives us the key exercise signal. So this first crop of papers was really our first look, cross-tissue, cross multi-omics, so multiple different modalities of measurement. And I think, yeah, we were like about nine and a half thousand assays, 19 tissues, 25 different measurement platforms, and then four training points for these rats. So let's talk about the rats for a minute. What do they do? So they normally live at night. They're active at night. In this study, we reverse that so that we can actually do the studies during the day.(04:25):So we reverse their at night cycle and they do their treadmill exercise over the course of several weeks. They start with about 20 minutes, and they do more every day. There's a control group of rats that just get placed on the treadmill and then don't do any exercise. And so, this is a controlled study as well. And over the course of time, we work more, it's about eight weeks in total and then two days after each of those bouts of exercise. So it's not an acute study, we measure to see where we are. So we also have this time trajectory of exercise. So what did we find? I mean, I think the first thing I would say, we talked about just how potent exercise is. It's very, very clear from looking at all these tissues that when you exercise regularly, you are just a different person, or in this case a different rat.(05:15):Like literally every tissue is changed dramatically and some in quite surprising ways. So I give you a couple of the things that surprised me or that I thought were most interesting. The first thing was this question of how does exercise actually work? Because exercise is a stress. You go out and you pound the pavement or you're on the bike or whatever, and then your body recovers. And so, there's been this idea, it's referred to as hormesis, this idea that some of the benefit of exercise might come from this recurrent stress. So your body learns how to deal with stress. And so given that we were very interested that this heat shock response was so prominent across multiple tissues. So heat shock proteins are molecular chaperones and they take care of protein folding to make sure it's appropriately done and they prevent protein aggregation. And when proteins need degraded because they're damaged, the heat shock system jumps in.(06:10):So perhaps not surprising, but pretty interesting that the heat shock proteins were very prominent part of the stress response to exercise. And remember, this is not acute exercise, so these are benefits that are built up over time, so that was one. A surprising one to me, the adrenal gland. So we're used to thinking of adrenaline as an epinephrine, as a stress hormone, but actually we saw dramatic changes in the adrenal gland and we don't necessarily think too much. You think about the exercising muscles, you think about the heart, we think about the lungs, when we think about exercise, you don't necessarily think that you're changing your adrenal gland, but it was one of the most changed tissues. The immune system was a common upregulated system. We saw that. And in fact, some of the tissues in which the immune genes were most changed were somewhat surprising.(07:02):So the small intestine, for example, was a place where there was a highest enrichment of immune mediated pathways. And then some tissues changed pretty early, like the small intestine changed after just one or two weeks of training other tissues like the brown adipose tissue. It was more like seven or eight weeks of training before we saw the real changes in there. So just one or two little things that struck out, but I think this really the first molecular map of exercise. So we're looking across the whole system across multiple modalities of measurement across multiple tissues.Simulating StressEric Topol (07:34):So as far as understanding the benefits of exercise, does this tell us that it really does simulate stress that it's conditioning the body to deal with stress as reflected by the various points you just summarized?Euan Ashley (07:51):Yeah, I think that is exactly right. I mean, part of what we were trying to understand was in what way are you changed after you do exercise regularly? And I think if we think about things that are positive, then the ability to deal with stress at a cellular level, quite literally repair mechanisms seems to be a big part of it. The other aspect that was interesting is that when you're measuring this many analytes, you can also compare that with disease. And so, we understand that exercises is preventive benefit against disease. So in some cases, and this was work highlighted by my colleague Maléne Lindholm in the mitochondrial paper that came along with the main paper and she looked with a team across all mitochondrial changes across all of the tissues of the cell. So these are the workhorses of the individual cells that like the batteries inside the cells of the mitochondria.(08:54):And we saw big changes across, it's not surprisingly, but it's the energy source for cells, big changes across many tissues. But interestingly for two specific really important diseases, a liver disease in one case and type 2 diabetes on the other, it was very clear that the training upregulated a network that was exactly the opposite of that of the disease. And so, it really was intervening in a way that was very specifically opposite to the way we know disease mechanisms go. So it does seem like, I mean people talk about an exercise pill. I think this shows that that is just not going to be possible. There may be ways we could mimic some elements of exercise, but there's no pill. This is a multisystem, multi-tissue, multidimensional response to exercise.Eric Topol (09:44):Yeah, I think it's really important. That was one of the questions I was going to ask you is whether this would ever be simulated by a drug. And I think you already answered that, and the fact that it's so comprehensively sweeping across every organ and all these different signals, tens thousand plus signals across them, it's really striking. We never really understood the benefits of exercise and not that it's all resolved by any means. Some of the things that were interesting too was the sex specific findings. Maybe you want to comment about that because we don't spend enough time thinking about how sex does have a big effect on physiology.Sex-Specific FindingsEuan Ashley (10:24):Yeah, I mean that's a really good point and one that I think was really underlined for us at every corner, every turn of the analysis here. So really no matter which measurement modality, no matter which tissue, no matter which point of training, if we just asked these computer models to sort of separate the data according to the prominent signals without giving it a clue of what to do, the so-called unsupervised models, then sex basically came out every single time. So I think you say you're absolutely right that we so often overlook the difference. For years we've said, oh, it's too expensive to do animal studies in both sexes, so we'll just pick one. And males were picked more often. But there are plenty of studies that were just females, and I mean that clearly is wrong, and we are really, sometimes it appeared like we're almost dealing with two different species.(11:18):They were so different. But I think we can also learn from what those differences were. Interestingly, some of them were most profound in adipose tissue, so in fat, and that was the case both at rest, sedentary and amplified by exercise. So we saw big difference between females and males in relation to the kinds of signals that were prominent in the white adipose tissue. So this fat storage tissue, for example, in sedentary females, insulin signaling and the trigger to make fat and store fat was very prominent. But whereas in the males, even before any exercise, the fat signals were more related to metabolism, and we could have wild speculation about in evolutionary terms why that might be. Obviously, males and females have different biological many differences in their biology and obviously thinking about hormone systems and specifically pregnancy of course. And so, we could probably come up with some theories. In reality, all we know now are these observations were found and they're pretty interesting and they show us that we really always need to think separately about both sexes and look at both independently.Eric Topol (12:39):Well, and the other thing that you already pointed out, but I just want to underscore, you can't do this stuff in people. You can't just do fat biopsies and whatnot. So I mean, the fact that you can do this multi-omic, multi-organ type assessment is just really an extraordinary opportunity for learning. And while we're on the white fat story just briefly, we would rather have a lot more brown fat, but as we age, and I assume it's the same in rats, they don't have much as they get older brown fat. Does exercise help us get more brown fat or are we just stuck with the white adipose tissue?Brown vs White FatEuan Ashley (13:21):Yeah, well, it certainly allows us to have less of a white adipose tissue, and I think it's potential that our brown adipose tissue maybe more functional, and for those who are listening who are not familiar, I mean these really are different colors that relate to the actual color of the tissue, but the color is different because the brown adipose tissue contains lots of mitochondria and lipid droplets, and the brown adipose is there to help essentially generate heat. It has a very different function in a way, but even white adipose tissue that we think of as just being about storing energy, people think of fat as a very metabolically neutral or inert tissue, but in reality it's not. It's signaling. It's constantly, it's a tissue that's as alive as any other and not just a storage for excess energy, but exercise definitely appears to alter both in this sexually dimorphic way as we noted already and clearly both in a positive health way where I think the makeup of the brown tissue is different. The white tissue, there is less of it obviously with exercise, which is something that is well known, but not new here for the first time. But still important to have seen that even in the rats.Eric Topol (14:49):And there's even, we talked a moment go about drugs, but there are some molecules that are thought to be able to help convert white to brown fat that are understudy and we'll see if they get anywhere that's interesting. But also, you talked about aerobic exercise and with us both being cardiologists, and I know throughout my earlier part of my career, we only talked about aerobic exercise. There was no such thing as strength training, and we even discouraged that or we never talked about it. Now we know how important strength training is and not just strength and resistance training, but balance and posture and all these other things. I assume you can't study that in the rats.Euan Ashley (15:32):Well, it's not impossible. This study of course is about endurance, but as you say, and there are some models, I mean I've even seen models in trying to trigger flies to do strength training.Eric Topol (15:46):Wow, I didn't know that.Intensity of ExerciseEuan Ashley (15:46):That somewhere, yeah, we'll have something, there are various methods of making animals hang off things, and this was treadmill. So it's a fairly routine and standard I think part of a rat's life to run. So this was not so different. As we mentioned at the beginning in the human study, we do have a strength portion and the endurance portion, which I think is very important because as you say, the benefits of exercise are found really across both of those. And indeed, as you say, flexibility and other often neglected element of physical activity. But yeah, those benefits are there for both aerobic exercise and endurance. And in fact, they are perhaps even higher for higher intensity exercise. Although I think we don't necessarily recommend everybody do higher intensity exercise. I don't think it's necessary to get most of the benefits of exercise, but there is some additional benefit.(16:42):One of my favorite facts, I think I first saw it probably on a presentation a few years ago, but I looked up the original and recalculated it. But if you look at this very big study of half a million people and look at their physical activity over the course of years and correlate it with their likelihood of being alive or being dead, then it was clear that one minute of exercise bought you five minutes of extra life. And I just thought that was just a really interesting way of putting it essentially. And actually it's a little more, if you did high intensity exercise, one minute would give you seven or eight minutes of extra life. So I tell this to my patients when they come in and tell me they don't have enough time to exercise. I said, oh, well, one minute of exercise. I'm not very popular when I tell them that, but anyway.Eric Topol (17:30):You think it's true. Do you think it's based on good data?Euan Ashley (17:34):Well, the data is large, I mean half a million people. I think we've also seen it currently since the early fifties when we were first doing the London bus conductor study that Jerry Morris did that you will know well, where he compared bus conductors on the London to the bus drivers and found a significantly reduced cardiovascular mortality among the conductors because they were on their feet all day up and down stairs and the driver otherwise in the same environment the drivers were sitting. So I think we have a wealth of epidemiologic correlative evidence that exercise leads to a greater length of life, greater longevity, maybe more than for anything else. The causal evidence is less of course, but we do have causal evidence too. There are enough randomized trials and now increasingly some genetic causal evidence that helps us understand that this is really a causal link and that we actually can change our outcome if we do additional exercise.Mental Health BenefitEric Topol (18:32):Oh, and I don't question at all what you said about the enhancing healthy aging health span and even possibly lifespan. I just wondered about the one to five ratio if we could assert that. I mean that's really interesting and it's a good motivating factor because as you well know by that WHO criteria, one out of four people aren't even close to the modest exercise recommendation. So we got ways to go to get people to spruce up exercise. Now speaking of people, I do want to come back to MoTrPAC and the people plan, but I do want to before that get your sense about a couple of really fascinating studies. So earlier this year there was a study of every exercise study that's been looking at mental health along with SSRIs that name drugs that are used for mental health. And it was a pretty fascinating study. I think I'm just going to pull it up. They looked at everything that this is for depression, walking, jogging, yoga, strength training, SSRIs. And what was fascinating is that dancing, walking, jogging, it made the drugs look like a joke. They didn't seem to work at all. So this was 218 studies with over 14,000 people. And so, I don't know that enough people recognize this fact that this Prozac nation and all this stuff about the SSRIs, but exercise seems to do wonders for people who are depressed, anxious, stressed. What do you think about that?Euan Ashley (20:26):Yeah, I mean it's exactly right. I mean I think that it's very clear from the data and as you mentioned, you and I tend to focus first on the cardiovascular benefit, which is very significant, potentially 50% reduction in risk, but there are similar sorts of numbers when you look at mental health and exercise as an intervention for mental health has been very well studied and has these really dramatic benefits. And I think even if we go in the more general population and think about the fact people talk about a runner's high or an exercise high, and many, many of us, myself included, feel that. And a few years ago, I started exercising every morning and now if I don't do that, I really feel like I'm missing something, there's something in the chemistry of my brain is not quite right. And so, I think that benefit for those who have mental health issues is also very much felt and is real at the brain chemical signaling level and with this few adverse effects as exercise has, I do think we need to think of it earlier and more prominently for almost every disease.Eric Topol (21:40):Yeah, you're I think alluding to the opioids that are released with exercise and addiction to exercise, which is what ideally if everybody could be addicted to exercise, that might help a lot of things. As you mentioned in your post that I started with, “its benefits in prevention outstrip any known drugs: 50% reduction in the cardiovascular disease, 50% reduction in risk of many cancers, positive effects on mental health that we just discussed, pulmonary health, GI health, bone health, muscle function. You name it.” So you said it really well there, and that was just one recent report that substantiated the mental health. I want to also mention another report that's fascinating on cancer that is a publication again recently was looking at both mice and people with pancreatic cancer. And what was fascinating about it is the more exercise of the mice and in the people, the more survival that is from pancreatic cancer, which as we both know and all the listeners will know, is that one of the worst cancers of humankind. So the affecting cancer is fascinating. Now can you dial up your immune system response with exercise?Euan Ashley (23:02):Yeah, I think you can. And I think we were at some level expecting to see it because it's certainly a known thing, but I think again, this is able, our ability to measure it in this study is just much deeper than we've ever had in any study before. And so, I think when we think about mechanisms that might relate to reduced risk of cancer, as you say, we think first of the immune system and that signal was there in many places. As we mentioned at the very beginning, sometimes to me in some slightly surprising places like the small intestine, we don't think of that necessarily as the seat of immune activation, but I think what we were doing, what we were seeing is those signals really across all the tissues and ultimately the immune system is a distributed system. It senses in multiple places and then obviously has implementation.(23:53):Now exactly in what way we've turned up our T or B cells, for example, to be able to attack those cancers or support the therapy that's been given. I don't think we understand that yet. But actually, you bring up another great point, which is part of MoTrPAC was to create this molecular map and analyze it and put the first analysis out there. So that's what we've done, but just as big and maybe even a bigger reason is that to release the data and to make it accessible for everyone and anyone in the world as of the moment this paper came out can go to our data portal at https://motrpac-data.org/ and download the data and then use that in their own work. They can do their own analysis just of this data, but also what we're hoping is that they'll start to use the data, let's say as control data for a cancer study or for a diabetes study or for others. So we really hope it'll fuel many, many more studies over many years from now.Eric Topol (24:52):Yeah, I mean that open science approach to applaud that it's so vital and amplifies what's good to come out of this really important initiative. Now you mentioned the opioids and proteins that are secreted with exercise, exerkines is a term that's used and also I guess these extracellular vesicles (EVs) not electric vehicles. Can you tell us about exerkines and EVs and are they part of the story?Euan Ashley (25:25):Yeah, and actually in the human study there's a specific exosome analysis that will be reported there. Yeah, I think that when we think about this multi-system nature of exercise, and one of the fascinating things was to be able to have these omics in multiple tissues and think about how those tissues were signaling to each other. So obviously there are some tissues that are more fundamental to the exercise response. We think of those as the skeletal muscles. They literally the effectors of our ability to exercise. And I think we think of the heart and lungs in particular in the blood system of course, but we were seeing changes everywhere and it's one of the reasons we were seeing changes everywhere is that there are molecules that are essentially secreted into the circulation or locally by these exercising muscles, exerkines that have a number of positive benefits.(26:21):And it is possible if there's some mechanism towards mimicking some of what exercise does with a drug, then that's a good place to go look for it. And I think that this will also fuel those thoughts. I think we both, we'd agree that there isn't going to be one pill that will do all the magic of exercise, but I think there are probably things we will learn from the study where we say, well, this was a very positive benefit and it seems to be mediated by this particular molecule, and that's something that could potentially lead towards a more targeted drug. I think we'll definitely get into that and understanding just we're systems people are, again, I think we think in physiology, so when we see the tissues like connecting and communicating with each other, I think that just makes a lot of sense from a systems perspective.Eric Topol (27:10):Now getting onto the forthcoming work that's going to come out with the 2,400 people and the different groups that you mentioned, I wonder if it'll include things like biologic aging with DNA methylation, will it have immunomes to characterize the differences in the immune system? What kind of things might we expect? Obviously, you can't get tissue, but for blood samples and things like DNA methylation, can we get some more illumination on what's going on?Euan Ashley (27:41):Yeah, I think we can. And of course, ultimately the human is the organism we're most interested in. Interestingly, I'll say interestingly as well, we can get some tissue and huge credit to both the investigators who are doing this and most credit of all to the individuals who agreed to join the study because they actually agreed not just to give blood samples, but actually to give skeletal muscle samples. So a biopsy of the skeletal muscle and a biopsy of the fat pad. So we will actually have two other tissues in the humans, not this obviously vast range that we talked about with the rat study, but we'll have those two other tissues and we'll also then have the rat data, which is the other great thing. So we'll have this foundational insight that we can then bring to the human study with the humans as we mentioned before as well, we'll have not just endurance but strength trained, we'll have it in kids as well, and we'll have these higher intensity exercise.(28:36):I think we will be able to connect with this, as you mentioned, longevity literature or the health span literature where we can start to think about DNA methylation. We do have genomes of course, on all of the individuals. It won't be a study powered because it's thousands individuals, these kinds of numbers. It won't be powered to give us genetic predictors. If you think about the studies had to be hundreds of thousands of people and even more now in order to give us, let's say common variant predictive. So we won't be able to do that, but there's lots of connections we'll be able to make by being much closer to the effector systems, which is to say the proteins and the metabolites and those signals we're already seeing are very significant. And so, I do think that there'll be a lot of new signals that we'll see that are specific to humans that will connect into other bodies of work, for example, the longevity, and we'll see those in blood and I hope that we'll be able to connect also the skeletal and adipose tissue data as well.Eric Topol (29:37):One of the things that would be wonderful to connect if you can, our mutual friend and your colleague at Stanford, Tony Wyss-Coray has these organ clocks that have been validated now in the UK Biobank, and then you can see what's happening with the wealth of plasma proteins that have been validated across each organ. So without having to do tissue, you might get some real insights about organ clock. So I mean, I'm really looking forward to the people part of this. When do you think the next wave of output's going to come from MoTrPAC?Euan Ashley (30:11):Well, I think that another element of the study is that we have ancillary studies, so investigators who said, I want to be able to use MoTrPAC data and use some of the infrastructure, but I'm looking for funding for my parallel study. So some of those ancillary studies will start to come out over time, which I think will be interesting and will be a very good place to see the breadth of activity that has been triggered by this one investment. The human study is coming along. We're actually just now plotting the last two or three years of the consortium. Time has really gone by pretty fast, and we've had to scale back just a little bit on the total numbers of humans, but it should still be, I think probably the largest multi-omics study of humans that there has been. And I think if we were going to plan one of those, then planning it to study around exercise definitely, definitely makes sense. So there is some data that was, of course Covid happened in the middle of this, so that was a major challenge with hitting the original numbers. But there's some data from the humans who were recruited before Covid hit that will be coming out and hopefully in the relatively near future. And then the big study may still be a year or two away to get it finished. But after that, as we say, we hope that the data and the science will continue for I hope decades beyond just the collection of this repository.Eric Topol (31:41):That's great. You mentioned Covid and I did want to ask you about the folks with Long Covid who are suffering from fatigue and exercise intolerance and what do you think about this kind of vicious cycle? Because if they could exercise, it could help them get into a better state, but because of not being able to, it's just a negative feedback loop. Any thoughts about that?Exercise and the Immune SystemEuan Ashley (32:13):I mean, it's such a good point and it's one of course that we talk to many of our patients where they, for whatever reason, sometimes it's because they are struggling with weight or they're struggling with other mobility challenges, and now we have this very large population who are struggling with fatigue. As you mentioned, it's a group that we were somewhat familiar with because of flu and because EBV and other, I mean long syndromes were something we were familiar with. They were just kind of rare, and so there wasn't really much work done on trying to understand them. Now as you've, I think articulated better than anyone, we have this entire population of people because of the scale of Covid who have these symptoms that are recognizable for the first time and including on your podcast, you have had folks on that have discussed it. Some of the insights that have happened from actually applying science, I wish there was an answer that was buried here in MoTrPAC and maybe there is, there will certainly have data from before and after the pandemic and maybe there may be some insights that we can bring to that.(33:20):I certainly think we have a lot of insights on the interaction between infection and the immune system. We talked about the potential for the immune system to be ramped up in that potentially being one of the mechanisms through which this might help cancer. There's also the idea of, and we've seen this with the effect of vaccination on Long Covid, which perhaps surprisingly does seem to have a significant benefit for at least a group of people. The assumption there is that we're ramping up the immune system and it's having that extra effect on whether it's actually pools of hidden antigens that are hidden from the immune system or whether it's some other element of the kind of ensemble attack of the immune system that is related to the symptoms. But either way, I think we feel that having a more ramped up immune system is likely to be beneficial, but at a very real human level, the point you made is the hard one. If you're really fatigued and you just feel you can't exercise, then these benefits are just out of reach and you're in this negative feedback cycle and breaking that cycle is hard. I think we try to suggest people do it very gradually because you can get a lot of benefit from just a little exercise and that's something, so that's some way, and then hopefully people can build up slowly over time, but it's a really big challenge.Eric Topol (34:43):I hope we can crack the case on that because I know that's something holding these folks back and there's just millions of them out there. Now let's talk about the healthy folks that you see in clinic. What do you advise them about exercise besides the fact that one minute we'll give them five minutes, but do you advise them to have X amount of aerobic and X amount of resistance and in the general person, what would you tell them patients?Euan Ashley (35:13):Yeah, yeah, I do. So I suggest habit is everything. So I suggest to people that they exercise every day or take one day of rest because I think there is some benefit with the stress response and having a rest day. So I suggest five or six days a week if possible, trying to get into a habit of doing it. So pick a time that works for you. It could be first thing in the morning, could be last thing at night. The jury's out on when the best time to exercise is. What it's very, very clear is that getting the exercise done is what counts. Accumulating time is also what counts. I mean, if you're not someone who wants to pull on running kit and go out running, that's fine, but accumulating steps, accumulating physical activity and moving is key. So not having people overshoot being too ambitious, but if they're really motivated to do something, then I would say five or six times a week a combination of both aerobic and endurance exercise and strength.(36:07):Usually I suggest two to one in favor of aerobic exercise, but it's also possible I think to alternate and do more 50/50. I think the key is that both are featured and then I think a bit neglected because to be honest, our data on it is just not as good, but flexibility is really critical and particularly in the senior population and for a group who sit all day long, I think for those two groups in particular, flexibility is really under-recognized as a major component. Even in my cardiology clinic, I've helped several patients just get over their back pain by teaching them some back stretching exercises. And so, I think that's neglected. So I suggest all three of those and really it's whatever works for the individual. I think the key is to find, it might be working in a group format, it might be going to a gym, it might just be taking regular walks. The key is to get moving and not sit. Get moving and do it regularly and get into the habit.Individualized Exercise?Eric Topol (37:09):Yeah, and actually on that point about potential individualization in the future, I noticed that you and some people that worked in your lab and others, Svexa is a company you started for exercise. Can you tell us about that?Euan Ashley (37:26):Yeah, this was a PhD student who was in my lab many years ago and was doing his PhD joint between the Karolinska Institute in Sweden. And of course, the country of Sweden has a long history of exercise physiology, science, and as he came out, we realized that there was the potential for optimization of training for individuals, whether they're recreational athletes or elite athletes in the Olympics. And he was interested in taking this and running with it, which he did. So the company originally Silicon Valley exercise analytics, but shortened now to Svexa builds, builds products to help people basically individualize their training. And we work, say with recreational athletes on an individual basis, we work with a lot of Olympic athletes in multiple countries and the technology building the sort of magic sauce that many of these coaches even up to and including Olympic coaches have into a format that can be spread and amplified to many more people is one of the themes.(38:29):And when we think about professional athletes and the company works with a number of well-known brand name teams that are in soccer leagues and in national football league here in the US and really across professional sport, what we're thinking of there is optimizing performance. Of course, all the teams want to win, but reducing injury is the other key part because the management of load, these are professional athletes, they're getting up every day in training and they're trying to optimize their training and their coaches are trying to do that. And it's been a fairly data free zone over the years, but meanwhile, we actually have learned a lot about how to measure individuals and how to measure what training works, and if you think about a team that might be paying 20 million a year for their star player, if that player gets injured, that's a pretty expensive thing. And so, investing a little bit in understanding the training load, helping the coaches understand the data, and then adapting that to each individual in the team so that their chance of injury is lower. That's really a lot of what the company spends its time thinking about.Eric Topol (39:36):Now, do you use sensors like lactate and glucose and AI of their body and how do you figure this stuff out?Euan Ashley (39:45):Yeah, all of that is possible. It's interesting, some sports have a kind of culture of measurement. For example, lactate measurements, which as your listeners will know, is it requires a small blood sample usually from the finger or from the ear lobe. Some sports like swimming have done that for years. But other sports, it's just not been so much in the culture. So I would say that from the company perspective, we work with whatever data is available and we'll make recommendations if people want to think about wearable devices. Of course, the digital era is around us, and you can get a lot from just a standard watch in terms of heart rate, heart rate variability in terms of accelerometry and movement. You can do a lot with just that, but there's lots more. Many of these teams have GPS signals so they know how far an athlete moves in a given game, how fast they move, how much time they spend at tool speed versus medium speed.(40:37):So we can use all of that. And as you say, yes, AI for sure is a large part of what we do and a couple of different ways actually. One is just for the analysis of the data, but another is this idea of scaling expertise. This is something in the AI community. I know you talked about a lot where you could take the expertise of let's say a physician with a very specialized practice or an Olympic coach for a marathon runner and basically make a language model that contains that expertise and then allow many people, thousands of people potentially to benefit from that expertise that we'd otherwise be sort of locked up with next available appointment is 18 months down the road, but if your AI can potentially reflect a lot of what you have, a lot of your expertise, not all of it, we hope, but probably a lot of it, then that expertise could potentially be offered much more broadly. And if it's to help people exercise more and more effectively, it's going to be a lot of good that I think can come from that.Eric Topol (41:33):Yeah. No, it's really interesting. I think there's unlimited opportunities there. It's like Moneyball to the 10th power. It's like all this data that's in sports that gets me, I guess to the last question I had for you, and that is the elite athlete or athlete hard. These are people that are working out endurance just to the max, these extremists, and they're prone to heart issues like atrial fibrillation. Why is that? What's going on with these people that they exercise too much? Is it just the lack of moderation, extremism or what's going on?Euan Ashley (42:10):Yeah, well, so it's interesting that of course you mentioned atrial fibrillation. I think that really is the only downside of exercise, even fairly extreme exercise that I've ever been, I think that we've ever had really good data for. And I would say that over the years, and I've been one way or another touching the exercise science world for 20 years and more now and certainly have been asked very often, surely these people are doing themselves harm. And the reality is, although every now and again there's a study that shows some harm or they measure troponin, they measure something in the blood and someone says, oh, they must be doing themselves harm. It's been very hard to find it. The reality is atrial fibrillation though really is, especially for those ultra endurance athletes, that's for real. And that is, we don't know that it's associated with a mortality impact necessarily, but it's definitely annoying and it slows down.Endurance Athletes and Atrial Fibrillation(43:03):We have athletes who come in and say they're cycling up a hill and suddenly they drop their power drops and they realize they've gone into atrial fibrillation. I used to play basketball with someone who would go into atrial fibrillation, so I would know when to try and get past him once he went into atrial fibrillation. But that's a real thing, and I think one of your questions was why I think I have a lot of close friends who are ultra endurance runners. They're among some of the most chilled and happiest people I know. I think those benefits of exercise are what they're enjoying, and I think there's a literature on addiction to exercise. So there is a small number of people who get addicted to that feeling and addicted to the chemical matter in their brain and can't stop, and they really do get to the point of doing themselves harm.(43:53):Fortunately, I think that's a pretty small number. And overall, although there are many consequences of chronic long-term exercise, almost all of them seem to be positive. The other one that you and I are probably very familiar with is the calcium scans that we see now much more often, it's common for people who've exercised a lot to have more calcium in their hearts. Now they have a lower risk of that. They have lower risk of heart attacks in general, one or two studies muddied the waters just a little. But in general, it's very clear they have very positive health benefits and yet they have more calcium. So they are an exception. We've seen in our sports cardiology clinic here at Stanford, several athletes every month, several will come in with this finding and we are explaining to them, this doesn't mean they have the same risk as someone who hasn't exercised at that level who would have that calcium score. It does seem to be very different, and it may be that there's a stabilization of those plaques in the arteries. I don't think we understand the biology that well, but we understand the epidemiology quite well, which is that their risk really is still low.Eric Topol (44:59):Yeah, no, it's interesting that there's still some uncertainties there and MoTrPAC may help guide us or at elucidate some of them. I guess it does bring up one other thing I got to get to with you because we didn't really get to the question of moderate to higher intensity, not to the level of the ultra exercises, but if you just do steps or do you sweat like hell, where do you draw the line? Or is that really part a function of age and ability? When you recommend exercise, because obviously you're rational and there's others out there that are exercising three or four hours a day and they're going to extreme craziness, but just in a reasonable thing, do you think just telling people who are 70 that walking is good enough or do you try to encourage them to push it?Euan Ashley (45:59):Yeah, I do encourage people to push it a bit because I think there's clear evidence that higher intensity, some degree of higher intensity exercise really does provide more benefit. But I think my main message first is because for most people, the potential of moderate versus high is in the distance and in the future for most people, we need to get them off the couch and get them on their feet. So my emphasis is that you can go a long way with just a little movement, even a little standing. And then I think if they're really getting into the habit and really doing some exercise then, and if they don't have a prior history of let's say, heart attack or other medical issues that might make high intensity exercise risky, if they don't have those, then I absolutely do get to the point where I recommend some amount of higher intensity exercise, because I think there is some evidence that it has a little extra benefit.Eric Topol (46:51):Oh, that's great. Well, this is the most in-depth conversation I've ever had with anybody on exercise, so Euan I really appreciate it. I mean, I knew you from all your work in genomics of course, and we've had some overlap from time to time, but the exercise stuff is fantastic. Did I miss anything?Euan Ashley (47:09):No, I don't think so. Just underline again to anyone who's listening if they're interested to play with this data, it's very much out there. It's a tool for the world, and they can go to https://motrpac-data.org/ and even you can do some analysis without downloading any data either. If you just have a favorite gene or a favorite protein, you can type that in and take a look at some of the tools we have there. But yeah, really appreciate the conversation and very fun to chat about what has been a really, really fun project.Eric Topol (47:39):Well, thank you and all the folks at MoTrPAC, all the hard work and of course the funding that got it going to give it that runway of several years. So we'll look forward to more. I hope to convene with you again when some of the other studies come out, and thanks so much.*****************************************************Thanks for listening, reading or watching!The Ground Truths newsletters and podcasts are all free, open-access, without ads.Please share this post/podcast with your friends and network if you found it informativeVoluntary paid subscriptions all go to support Scripps Research. Many thanks for that—they greatly helped fund our summer internship programs for 2023 and 2024.Thanks to my producer Jessica Nguyen and Sinjun Balabanoff for audio and video support at Scripps Research.Note: you can select preferences to receive emails about newsletters, podcasts, or all I don't want to bother you with an email for content that you're not interested in. Get full access to Ground Truths at erictopol.substack.com/subscribe
Welcome to The Basement! In this show, we discuss trending cryptocurrency news with a sprinkle of politics, economics, and pop-culture.
Episode SummaryRebekah Gardner and Jason Keever discuss how the tax industry has evolved significantly in recent years to keep up with digitalization and changing client needs. They explore how Ryan is leveraging technologies like artificial intelligence to improve efficiency and deliver exceptional client value. The speakers highlight the importance of breaking down silos between professional services and product teams. They emphasize building trust, communication, and incentives to encourage collaboration. Gardner and Keever also address balancing innovation through new product development while maintaining important client relationships. Keever provides an example of how AI could streamline processing large volumes of variable tax documents. About the guests Rebekah Gardner Rebekah is a relationship-focused global sales leader with over 20 years of experience as a federal tax partner. She has a proven track record across multiple industries, and from small businesses to Fortune-ranked companies. Her expertise spans private equity, strategic partnerships, and software channels, all underscored by a commitment to collaboration, accountability, and achieving results. Connect with Rebekah Gardner Jason Keever Jason serves as the President of Ryan's tax.com™ division. With over 15 years of experience in driving revenue for private-equity-backed, high-growth SaaS companies, he leads the executive team in expanding technology services for existing clients and venturing into new markets. Jason's previous leadership roles include Chief Revenue Officer, President, Chief Sales Officer, and Vice President of Sales across various industries. Connect with Jason Keever Key takeaways- The tax industry has significantly evolved to keep up with digitalization and changing client needs and expectations. - Technologies like AI can be leveraged to improve work efficiency and enhance the client experience. - It's important to break down silos between professional services and product teams through improved trust, communication, and aligned incentives. - Companies must balance innovation through new product development while maintaining important client relationships. - Accumulating and analyzing vast amounts of industry data can provide a competitive advantage through solutions like streamlining document processing. Quotes"Now one of the prominent pieces of the conversation with Clients is inevitably, what technology are you using to get this done? How are we certain that you are doing this in the most efficient way?" -Rebekah Gardner "We're uniquely positioned, we're uniquely focused on corporate tax, and we have the breadth of data that's going to help empower that type of movement in the market."-Jason Keever Recommended Resource Books Good to Great by Jim Collins Dare to Lead by Brene Brown Scaling People by Claire Hughes Johnson Amp It Up by Frank Slootman
Everything you ever wanted to know about ADHD...continues! WOOHOO! Go back and check out Part I, or start here to learn more about what's happening in the brain, how to use environments to cue ourselves, how debate and manufactured fights can be ways to help you focus, and more! The things that are easy, hard, and all the myths and misperceptions that exist about what is really not a deficit, but rather an abundance and variety of, attention. The second part in a series from David, who has lectured as an expert and advocate on this subject nationally, and assisted by Isabelle, who is eagerly sponging up the information. A neurodivergent and neurotypical blend of friends Christina, AJ, Gabe, and Isabelle's husband, Bobby, sit in to ask questions. (Part II of David's Lecture Series)---(Part II of David's Lecture Series) Isabelle & David welcome Isabelle's husband, Bobby, and their friends, Christina, AJ, and Gabe, to continue to listen and learn from David's tried and tested presentation on ADHD, which he normally gives to fellow clinicians (for the first part of this talk, please see episode 4, David's Lecture: All About ADHD!). We talk about Auditory Processing Disorder (APD) which often also exists alongside ADHD; however, they are two different things. ADHD can make you more prone to distraction when you hear sounds, no APD (see definition below). ADHD can also coexist with Autism Spectrum Disorder (ASD). David gets nerdy about how blood flow to certain parts of our brain connects to distraction, and how our environment can also cue us to shift blood flow to the forebrain (prefrontal cortex). Gabe notes that sports served as an important accommodation. David makes the comparison that it's like having an energy bar in a video game, and if you don't use it during your day, it will become anxious rumination at night. David and Bobby get distracted by Bobby's audio equipment (or Bobby tweaking his audio settings) and David points out that being oppositional rewards us with dopamine. Debate as a dopamine booster. As a parent, how do you get out of power struggles. Talking about ADHD as too much gas (hyperactive) and too much brakes (inattentive); combined type is both, and environmentally cued (the more comfortable you are, the more gas; the less comfortable you are, the more brakes). What about ADHD on vacation? We can get more irritable or more chill, and it can be because we have uprooted our accommodations: the structure we have in place at home that helps us get along. So we can start to manufacture structure (including undertaking vacation-only projects, getting into a predictable arguments, reading a book in a day, etc.). When we understand how ADHD impacts us (for example, starting to write a book on vacation to cleverly avoid interactions we don't want to have, plus building in structure…but not finishing because we didn't factor in the response cost of it) we can work with it.Click here for slides from David's lecture.How genetically loaded is ADHD?Pretty loaded. For more on this, check out this article in Nature (prepare for science!)On a related note, this article also points to ADHD being more of a spectrum than previously thought; as the article mentions:"Accumulating evidence from family, twin, and molecular genetic studies suggests that the disorder we know as ADHD is the extreme of a dimensional trait in the population. The dimensional nature of ADHD has wide-ranging implications. If we view ADHD as analogous to cholesterol levels, then diagnostic approaches should focus on defining the full continuum of “ADHD-traits” along with clinically meaningful thresholds for defining who does and does not need treatment and who has clinically subthreshold traits that call for careful monitoring. The dimensional nature of ADHD should also shift the debate about the increases in ADHD's prevalence in recent years. Instead of assuming that misdiagnoses are the main explanation for the increased prevalence, perhaps researchers should explore to what extent the threshold for diagnosis has decreased over time and whether changes in the threshold are clinically sensible or not.”In other words, ADHD is part of a set of traits that live along a spectrum, and since we tend to diagnose ADHD when those traits/behaviors/experiences are read as a problem, we lump it into it's own bag, when really it might turn out to be a neurodivergent branch of the same tree. And so those with ADHD can exist all along a spectrum, too! Hence: calling it attentional variability rather than a deficit.DAVID'S DEFINITIONS:Auditory Processing Disorder (APD): a hearing disorder and has to do with how the brain processes auditory information. APD can impact attention as well, but it's not ADHD. Note: ADHD can make it harder to hear certain sounds, for example a person's voice in a noisy setting, but the mechanism behind why it's hard is different than APD. Autism Spectrum Disorders (ASDs): a group of developmental differences (AKA neurodiversity or differences in the brain) that can cause increased sensitivity to stimulation, social, communication and behavioral challenges. Prefrontal Cortex (PFC): also known as the forebrain, is a part of the brain that, through dopamine, is linked to executive functioning, or the skills (check out the list below) that help you pay attention, curb your impulses, take in memories (working memory), and play with different scenarios and outcomes (cognitive flexibility), for starters. For further reading, check out this super science-y article. Forebrain skills that are harder for folks with ADHD (no matter the type): Response Cost - neurological skill that helps you know the consequences of your actions later on down the road Delay of Gratification - receiving the reward or win, well after the behavior occurs.Black and White Thinking - believing or acting as if there are only two ways of thinking right or wrong. Black and white thinking makes it harder to see middle paths during an argumentTime and Organization Skills - knowing how long tasks will take, planning transition times into tasks, appropriately guessing how long something will take, or all parts of time and organizational skills.-------cover art by: Sol Vázqueztechnical support by: Bobby Richards
- Western collapse and NATO's priorities of pushing LGBT propaganda. (0:03) - Ukraine has become a failed state. (4:37) - ICC seeking arrest warrants for Israeli and Hamas officials for war crimes and crimes against humanity in #Gaza. (18:41) - Israeli actions in Gaza are #genocide. (26:44) - RFK Jr.'s support for Israel's actions in Gaza, criticizing his stance as pro-genocide and anti-humanitarian. (33:38) - Why the rest of the world will celebrate the collapse of the US empire. (44:07) - All people have the right to resist occupation and defend their land. (57:37) - Zionism is a philosophy of ethnic supremacism, violence and inequality. (1:02:50) - Geopolitical events and precious metals prices with the "Silver Guru" David Morgan. (1:08:47) - #Silver market, predictions, and strategies for investors. (1:14:47) - #Inflation, #gold, and economic instability. (1:25:57) - Accumulating wealth through gold. (1:37:31) - Potential for #BRICS currencies to replace US dollar in international trade. (1:39:47) - The potential end of fiat currency and the rise of decentralized currencies. (1:48:43) For more updates, visit: http://www.brighteon.com/channel/hrreport NaturalNews videos would not be possible without you, as always we remain passionately dedicated to our mission of educating people all over the world on the subject of natural healing remedies and personal liberty (food freedom, medical freedom, the freedom of speech, etc.). Together, we're helping create a better world, with more honest food labeling, reduced chemical contamination, the avoidance of toxic heavy metals and vastly increased scientific transparency. ▶️ Every dollar you spend at the Health Ranger Store goes toward helping us achieve important science and content goals for humanity: https://www.healthrangerstore.com/ ▶️ Sign Up For Our Newsletter: https://www.naturalnews.com/Readerregistration.html ▶️ Brighteon: https://www.brighteon.com/channels/hrreport ▶️ Join Our Social Network: https://brighteon.social/@HealthRanger ▶️ Check In Stock Products at: https://PrepWithMike.com
Have you ever felt like there was a disconnect between what the researchers are thinking and what you, as a clinician, are thinking? You're not the only one! The desire to bridge the gap between research and what really goes on in the clinic has been a topic of discussion for decades. We interviewed Dr. Carolee Winstein, PhD, PT, FAPTA about this very topic and what the possible solutions may be. Dr. Winstein, a pivotal figure in redirecting professional focus towards motor control, motor learning and neuroplasticity, shares her transformational journey. When working with individuals with neurologic conditions in the 1990s (“before neuro rehab was a thing,” as she laughs) she wondered, why do some people get better and some don't? Her intellectual curiosity propelled her into the sphere of motor learning and control under the tutelage of the esteemed Richard (Dick) Schmidt, PhD, an intellectual leader in motor learning and control and founder and founding editor of the Journal of Motor Behavior. Accumulating over 34,000 citations, Dr. Winstein stands as a luminary in the realm of neuro rehabilitation, boasting an unparalleled expertise in motivation, motor control, and neuroplasticity. She shares why the practice of neuro rehabilitation must be accompanied by an understanding of the behavioral literature. She provides advice and guidance for the clinician struggling to incorporate the research into practice, a warning about Clinical Practice Guidelines (CPGs), and what types of studies you should actually pay attention to in order to implement emerging evidence. Have you ever felt like your patient population doesn't really match those studied in the research? She addresses that too and provides advice and encouragement about how to shift this disconnect. Articles mentioned in the interview can be found and downloaded here: Boyne, et al Optimal Intensity and Duration of Walking Rehabilitation in Patients with Chronic Stroke Dawson, et al Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischemic stroke (VNS-REHAB) Hornby, et al Clinical Practice Guideline to Improve Locomotor Function Following Chronic Stroke, Incomplete Spinal Cord Injury, and Brain Injury Tsay, et al Five Features to Look for in Early-Phase Clinical Intervention Studies
Let's Talk about Wealth...What and How do you define TRUE Wealth? Examples of Wealth categories: Health, Relationships, Time, Family, Knowledge, Money, Assets, etc. 3 most Important Types of Wealth: 1- Health 2- Relationships 3- Finances Note- truly determine what factors are important to you in each... #1- Health- state of high energy and enthusiasm Health is the corner stone of wealth that affects all other wealth categories. Several parts....not just physical.... ...energy...enthusiasm...body and mind Formula for great health is made of of diet, exercise, attitude and mindset. Mental discipline can be considered a key ingredient of physical and mental health. Benefits: manage stress, anxiety, better energy, clarity, peace and self image and confidence. NOTE- water is a key ingredient of great physical health. #2- Relationships- love, respect, admiration and closeness with other people in your life. Many areas of relationships...partner, family, friends, and partners... Take inventory often...build and maintain Key ingredients to improve your relationships...TIME and APPRECIATION (gratitude) NOTE- learn to prioritize this type of wealth and VIEW it as a true asset in life...will influence other areas. #3- Money Wealth- accumulation of assets, security and lifestyle Most people don't track...this is key to accomplishing anything. What are your numbers? What do you want? What are you trying to accomplish in life, business and lifestyle? 4 Critical Areas or Steps to Accumulating and Appreciating Money Wealth 1- Attitude- abundance, value, investment v expense, gratitude 2- Protection #- emergency cash to cover your needs for 1-2 years 3- Independence #- enough cash or investments to cover your needs without active income (but don't stop active) 4- Freedom #- enough cash or investments to cover your "wants" and lifestyle NOTE- Money is a result...of mindset, activity, strategy and focus. Money is a tool not a destination. Money is simple but requires discipline and consistency. Learn to budget, track, focus and value the money you have. How you do anything is how you do everything... thanks for listening today. see you tomorrow. George Wright III Visit jointheevolution.com for more ways we can work together.
Let's Talk about Wealth...What and How do you define TRUE Wealth? Examples of Wealth categories: Health, Relationships, Time, Family, Knowledge, Money, Assets, etc. 3 most Important Types of Wealth: 1- Health 2- Relationships 3- Finances Note- truly determine what factors are important to you in each... #1- Health- state of high energy and enthusiasm Health is the corner stone of wealth that affects all other wealth categories. Several parts....not just physical.... ...energy...enthusiasm...body and mind Formula for great health is made of of diet, exercise, attitude and mindset. Mental discipline can be considered a key ingredient of physical and mental health. Benefits: manage stress, anxiety, better energy, clarity, peace and self image and confidence. NOTE- water is a key ingredient of great physical health. #2- Relationships- love, respect, admiration and closeness with other people in your life. Many areas of relationships...partner, family, friends, and partners... Take inventory often...build and maintain Key ingredients to improve your relationships...TIME and APPRECIATION (gratitude) NOTE- learn to prioritize this type of wealth and VIEW it as a true asset in life...will influence other areas. #3- Money Wealth- accumulation of assets, security and lifestyle Most people don't track...this is key to accomplishing anything. What are your numbers? What do you want? What are you trying to accomplish in life, business and lifestyle? 4 Critical Areas or Steps to Accumulating and Appreciating Money Wealth 1- Attitude- abundance, value, investment v expense, gratitude 2- Protection #- emergency cash to cover your needs for 1-2 years 3- Independence #- enough cash or investments to cover your needs without active income (but don't stop active) 4- Freedom #- enough cash or investments to cover your "wants" and lifestyle NOTE- Money is a result...of mindset, activity, strategy and focus. Money is a tool not a destination. Money is simple but requires discipline and consistency. Learn to budget, track, focus and value the money you have. How you do anything is how you do everything... thanks for listening today. see you tomorrow. George Wright III Visit jointheevolution.com for more ways we can work together.
Music is probably one of the last things you'd pay attention to when out for a meal or drink - but it can make or break the whole experience. We've all been to a restaurant or bar where the music is so loud, you can barely hear the person sitting next to you, or it's too quiet and it feels like a ghost town. Creating the perfect ambience may not be as simple as it seems - in fact some businesses spend years accumulating the right tunes to keep you comfortable and coming back for more. Reporter Jordan Dunn sat down with owners and managers at some top spots in Auckland to ask 'what goes into the art of ambience?'
When you think of the word "brave" you might think of big, bold acts with huge, transformative reward that follows, but today I wanted to talk about how you can be brave in your everyday - I give 9 tools to become braver in both big and small ways that will ultimately build confidence and see you change your life for good. How have you been brave recently? Let's chat in the comments. Love always, Cass xx (00:00) - Hello! My update (05:06) - When I think of the word “Brave” (06:56) - Harnessing courage (08:13) - 9 ways you can grow and be brave as a person… (08:37) - 1. Building Optimism (gratitude, self-talk, pre-planning pathways to your goals, visualisation) (17:20) - 2. Finding Courage (comparison, finding your “brave”) (20:38) - 3. Increasing Confidence (keeping promises to yourself, affirmations) (26:09) - 4. Accumulating competence and knowledge (learning, reading, growing) (30:41) - 5. Engaging in physical fitness (feeling physically able to meet your personal needs) (34:09) - 6. Practice (consistency, making it automatic, reinforcement) (40:40) - 7. Accepting responsibility (prosocial motivation) (45:54) - 8. Surrounding yourself with people you see as brave (be ruthless with who gets your brain space, group positive effect) (50:13) - 9. Speaking with a professional (knowing when to see help, this can sometimes be the bravest thing of all) (53:01) - Asking for help can be one of the bravest things a human being can do.
For this episode we're highlighting one of our interviews from the past! Originally recorded in June 2022. Andrew Coates is widely described as "The Mayor of the Fitness Industry" for his ability to connect people with one another and for his infectious passion for learning and helping others. This episode covers continuous learning, effective communication, critical thinking, application over theory, and adaptability and also includes a book list Andrew recommends for those wanting to get into writing. Find that here! Help Us Help More People. When you leave a review on apple or Spotify, it helps us share the message so that we can raise the industry standards and help more people for free. About The GuestAndrew Coates is a distinguished fitness professional dedicated to enhancing the wellness and strength of his clients through personalized coaching and comprehensive fitness education. With a background rich in competitive sports including cross-country skiing and basketball, Andrew's passion for fitness burgeoned in his early twenties, leading him to become a certified personal trainer in 2010 in Edmonton, Alberta. Accumulating over 19,000 client coaching hours, he has established himself as a pivotal figure in the fitness industry.At the core of Andrew's philosophy is a commitment to creating a welcoming and enjoyable workout environment. He understands the intimidation many feel towards the gym and strives to demystify fitness routines, making them accessible and engaging. Beyond physical training, Andrew places a strong emphasis on sustainable nutrition and overall lifestyle improvements, including sleep and mindset strategies, to support his clients' journeys towards health and strength.Andrew's approach is holistic, catering to a diverse clientele that ranges across ages, genders, and fitness goals. He offers both in-person coaching at Evolve South in Edmonton and online coaching for clients who prefer virtual support. Andrew's method involves a tailored program for each individual, focusing on developing their confidence and competence in their fitness journey while fostering independence.Educationally, Andrew brings a wealth of knowledge and a continuous hunger for learning. He is a graduate of Memorial University of Newfoundland with a Bachelor of Commerce (Co-op) Honours. His commitment to staying at the cutting edge of exercise science and nutrition is evident in his dedication to reading, studying, and attending every expert conference possible. Additionally, Andrew shares his insights and learns from industry leaders through his weekly fitness podcast, "Lift Free & Diet Hard," and his contributions to major fitness publications.As a mentor, writer, and podcaster, Andrew is not only a resource for his clients but also for fitness professionals worldwide. His personal interests, including a love for the band Tool, the world of The Witcher, and highland single malt scotch, add depth to his character, making him a relatable and approachable figure in the fitness community.For those interested in learning from Andrew's extensive experience and unique approach to fitness and wellness, visiting his website provides a gateway to a wealth of resources, coaching opportunities, and insights into his philosophyLinks:https://andrewcoatesfitness.com/https://www.instagram.com/andrewcoatesfitness/Join the Facebook community!Are you a new fitness entrepreneur looking to attract clients? Maybe you're looking to dial in your messaging? Or perhaps you're experienced and looking to scale your business?Head on over to Facebook, and request access to my Online Marketing for Fitness Professionals group. Post an introduction about yourself, ask some questions, or let us celebrate your wins with you.BSimpsonFitness Best Next Steps Simple Scaling - Want the fastest most efficient way to start and scale a profitable business in the health and wellness space, with less than 2k followers or DMing 100 cold people a day? Watch this short free training and I'll show you how for free. Tap here to register: https://www.ptprofitformula.com/simplescalingPT Profit Formula - 10k in 90 Days or you don't pay, let me show you how it works for free. Learn more here: https://www.ptprofitformula.com/formulavsl/PT Profit Formula Jumpstart - a step-by-step proven process to generate consistent 10k Months in 30 Days with just a handful of followers and without sleazy sales. https://www.bsimpsonfitness.com/jumpstartThe Complete 10k Per Month Blue Print - FREEhttps://www.bsimpsonfitness.com/10kblueprint/ This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit beverleysimpson.substack.com
Ever wondered how to turn renters into homeowners through savvy real estate investing? Dive into the world of rent-to-own strategies with our latest episode of Exit Strategies Radio Show! Joining us in this episode is James Brown, co-founder of Real Home Solutions, realtor, investor, and creative financing coach, known for his expertise in rent-to-own strategies. James delves deep into the world of real estate investing, focusing on innovative rent-to-own approach. He shares his journey from graphic designer to real estate mogul, highlighting the pivotal moments that led him to explore creative financing options. In this episode, learn insights into the benefits of rent-to-own models, multifamily investing, and passive investment opportunities. James's practical advice and real-world examples provide actionable steps for aspiring investors looking to break into the market or expand their portfolios. Key Takeaways: 03:17 - James Brown's background: From graphic design to real estate investing. 05:18 - The allure of real estate investing: Control, flexibility, and long-term wealth-building. 12:42 - The Nomad Investor strategy: A simple yet effective approach to building a real estate portfolio over time. 16:37- Accumulating long-term rentals through continual investment Connect with James@: Linktree: https://linktr.ee/partnerwithjamesbrown Website: https://www.realhomesolutions.org/https://www.realhomesolutions.org/ Podcast: https://www.unitedstatesrealestateinvestor.com/this-month-in-real-estate-investing/ Website: https://hybridrealestateinvesting.com/category/podcast/ Connect with Corwyn@: Contact Number: 843-619-3005 Instagram: https://www.instagram.com/exitstrategiesradioshow/ FB Page: https://www.facebook.com/exitstrategiessc/ Youtube: https://www.youtube.com/channel/UCxoSuynJd5c4qQ_eDXLJaZA Website: https://www.exitstrategiesradioshow.com Linkedin: https://www.linkedin.com/in/cmelette/ Shoutout to our Sponsor: EXIT Realty Lowcountry Group Do you want something more? More Meaningful Moments opportunities, deeper relationships and memorable experiences? Do you want to make a difference? If you say YES, a career and real estate could be the opportunity you're looking for guiding people to one of the most important decisions they ever made, the purchase or sale of their home can be both rewarding and lucrative. EXIT Realty has a revolutionary compensation model training and technology that provides you with the tools you need to start and build your successful real estate career. Call EXIT Realty Lowcountry group today at 843-619-3005 that is 843-619-3005 or visit https://exitlowcountry.com/joinexit and make your Exit today. --- Support this podcast: https://podcasters.spotify.com/pod/show/corwyn-j-melette/support
EP Wealth CFP Chad Burton discusses Retirement Readiness Ideas with Rob, Ways for Accumulating and Keeping Wealth in 2024, More on the 7 Steps for Retirement Readiness Seminar at Stanford Park Hotel in Menlo Park on Thursday February 15th 6:30pm to 8:30pm
EP Wealth CFP Chad Burton discusses Retirement Readiness Ideas with Rob, Ways for Accumulating and Keeping Wealth in 2024, More on the 7 Steps for Retirement Readiness Seminar at Stanford Park Hotel in Menlo Park on Thursday February 15th 6:30pm to 8:30pm
This is actually a very personal account of my journey and what happened to me. I use this to explain how I came to be who I am and why I started my channeling. My souls purpose has been to voraciously accumulate knowledge. While this is not all its cracked up to be and it does not reveal all the answers you may relate to my journey in this regard.
In the second part of our series on rental properties, we're exploring the other side of real estate investing - the challenges and pitfalls. It's not just about the pros; understanding the cons is crucial too. We'll dive deep into the costs, risks, and responsibilities that come with investing in real estate. Whether you're a seasoned investor or just starting out, this episode is packed with essential information.Connect on Instagram:Seychelle Van Poole: @seychellevpSarah Reynolds: @sarahreynoldsojiWendy Papasan: @wendypapasanKymber Lovett-Menkiti: @kymbermenkitiTiffany Fykes: @tiffanyfykesProduced by NOVA Media
Get ready to dive deep into one of my favorite wealth-building strategies: investments in rental properties. In this episode of Empire Building, we're going to explore the ins and outs of purchasing and accumulating rental properties—a topic I believe many of us have been curious about for years.Here's what we'll cover:Definition of a Buy and Hold Rental Property: We'll start by defining what a buy and hold rental property is and how it differs from other types of investments.The Kinds of Rental Properties You Can Buy: There's a variety of rental properties out there, and we'll look at the different types to help you understand your options.Pros and Cons of Owning Rental Properties: Like any investment, there are upsides and downsides. We'll discuss both so you can make an informed decision.Loan Considerations for Buying a Rental Property: Financing is a crucial part of property investment. We'll delve into the types of loans available and what to consider when securing one.The Costs Associated with This Kind of Investment: Lastly, we'll break down the costs involved in investing in rental properties to give you a clear picture of what to expect.Whether you're a seasoned investor or just starting to explore the idea of rental properties, this episode is packed with valuable insights. Don't miss out on this informative discussion that could potentially change the way you approach wealth building through real estate.Connect on Instagram:Seychelle Van Poole: @seychellevpSarah Reynolds: @sarahreynoldsojiWendy Papasan: @wendypapasanKymber Lovett-Menkiti: @kymbermenkitiTiffany Fykes: @tiffanyfykesProduced by NOVA Media
We are so freaking lucky, Fortune Feimster is here! We had a blast diving into her character alter egos, hoarding wigs, and her start at the Groundlings Theater. We talked about Fortune's transition from journalist to comedian and she gave me a sneak peek into Chelsea Handler's hilarious hiring practices. Please note, Funny Cuz It's True contains mature themes and may not be appropriate for all listeners. Stay up to date with us on Twitter, Facebook, and Instagram at @LemonadaMedia. Joining Lemonada Premium is a great way to support our show and get bonus content. Subscribe today at bit.ly/lemonadapremium. Click this link for a list of current sponsors and discount codes for this show and all Lemonada shows: lemonadamedia.com/sponsors You can find all show transcripts on the Funny Cuz It's True page here.See omnystudio.com/listener for privacy information.
The guys suffer through Happy's dog farts while they discuss how Justin and Kate ate rancid meat and lived to tell the tale, then Christian recounts how he said something awkwardly sexual in the presence of some manly bros. We read a letter from Courtney about that one time Justin touched her shoulder after Seminar on Broadway, plus she offers a WYR about whether they'd want to receive a compliment a day or a bit of helpful feedback a day. Finally, we hear a voicemail from Zaira full of compliments and a WYR about having long toe nails vs finger nails. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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