Podcast appearances and mentions of leonard guarente

Subscribe to our channel: https://www.youtube.com/@optispan Check out Scott Carney's channel: https://www.youtube.com/@sgcarney Related episodes: The True Story of David Sinclair's Longevity Lie: https://www.youtube.com/watch?v=xQrXs7CxIjk DON'T Take Resveratrol Until You Watch This Video: https://youtu.be/MmIBdqsQYfw Scientists Debate How to Live Longer & Longevity Drugs: https://youtu.be/EebH_taOlAA An introduction to the study of RAPAMYCIN: https://youtu.be/czx_-DqnnrQ In this episode, Matt and Nick react to investigative journalist and author Scott Carney's video describing what he calls "David Sinclair's longevity lie" in the context of David's longevity-focused entrepreneurial ventures. Matt shares his professional history with David, including his early interactions with David in Leonard Guarente's lab at the Massachusetts Institute of Technology (MIT) and scientific differences that emerged after Matt and colleagues were unable to reproduce a key result from David's work pertaining to resveratrol. Their discussion touches on some of David's scientific claims about age reversal, the role of institutions such as Harvard University in regulating scientific integrity, the potential for future interventions in healthspan and longevity, and the importance of separating personal feelings from scientific evaluation. David, currently a professor in Harvard Medical School's Department of Genetics at the Paul F. Glenn Center for Biology of Aging Research, is a prominent geroscience researcher whose lab focuses on age-related epigenetic change, cellular reprograming, longevity drug discovery, mitochondrial fitness, reproductive aging, neurodegenerative disease, and the human secretome. He has received awards including the National Institutes of Health Nathan Shock Award, the Merck Prize, and the Australian Medical Research Medal, and was elected to TIME's 2014 “100 Most Influential People in the World" list. David conducted postdoctoral research at MIT and obtained a PhD in Molecular Genetics at the University of New South Wales. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.

#agereversal #science #biotechnology #ageing #health #podcast #toctw Dr. Brian Kennedy is internationally recognized for his research in the basic biology of aging and as a visionary committed to translating research discoveries into new ways of detecting, delaying, preventing, and treating human aging and associated diseases. He is a Distinguished Professor in Biochemistry and Physiology at the Yong Loo Lin School of Medicine at the National University Singapore (NUS) and serves as Director of (1) the Centre for Healthy Longevity at the National University Health System, (2) the Healthy Longevity Translational Research Programme and (3) the Asian Centre for Reproductive Longevity and Equality at NUS. Collectively, NUS aging research seeks to demonstrate that longevity interventions can be successfully employed in humans to extend the health span, the disease-free and highly functional period of life. From 2010 to 2016, Brian was the President and CEO of the Buck Institute for Research on Aging and he maintained a professorship there through 2020. Brian has an adjunct appointment at the Department of Biochemistry at the University of Washington, where he was a faculty member from 2001 to 2010. In addition, he is also actively involved with a number of Biotechnology companies and serves as a Co-Editor-In-Chief at Aging Cell. His Ph.D. was performed in the laboratory of Leonard Guarente at M.I.T., where he published the first paper linking Sirtuins to aging. Dr. Brian is also the scientific Advisor for Rejuvant https://sg.linkedin.com/in/brian-kennedy-69777318 https://twitter.com/bkennedy_aging

Nick talks to biologist Dr. Leonard Guarente about the biology of aging, life extension, health supplements, and related topics. Dr. Guarente is a Professor of Biology at MIT, where his lab has studied the molecular and cellular mechanisms of aging for many years. He is also the co-founder and Chief Scientist of Elysium Health, which uses the science of aging to develop health supplements to combat age-related decline and technologies to help consumers understand their rate of aging. Nick and Dr. Guarente discussed many topics related to aging, including: how and why aging occurs; whether humans can achieve immortality; NAD and the core metabolic processes of cells; resveratrol, pterostilbene, and other anti-aging molecules; epigenetics and technology that can be used to calculate biological age vs. chronological age. USEFUL LINKSSign up for the weekly Mind & Matter newsletter[https://mindandmatter.substack.com/?sort=top]Follow Nick's work through Linktree:[https://linktr.ee/trikomes]Elysium Health, a life sciences company focused on aging research. Use code MIND for 10% off first purchase of any of their supplement products. Valid until 6/22/2022.[https://www.elysiumhealth.com/discount/MIND]Athletic Greens, comprehensive daily nutrition (Free 1-year supply Vitamin D w/ purchase)[https://www.athleticgreens.com/mindandmatter]Organize your digital highlights & notes w/ Readwise (2 months free w/ sub)[https://readwise.io/nickjikomes/]Download the podcast & follow Nick at his website[https://www.nickjikomes.com]Try Levels Health to monitor your blood sugar & optimize your diet[https://www.levelshealth.com/join?partner=MINDANDMATTER]Support the show

Gil is the Founder and Chief Scientific Officer at InsideTracker. He is internationally recognized for his research in the biology of aging and translating research discoveries into new ways of detecting and preventing age-related conditions. Gil received a Ph.D. in biology from the Weizmann Institute of Science and completed his Post Doctoral fellowship at MIT where he worked in Leonard Guarente's lab alongside David Sinclair and others alike. Follow Gil on Twitter @gblander1. [2:18] - How Gil's early interest in biology led him to a focus on longevity [10:01] - InsideTracker's model for predicting lifespan using blood analytics [16:28] - General recommendations for living a longer and healthier life [20:07] - The importance of personalized recommendations for optimizing health [22:34] - The difference between normal and optimal target ranges for biomarkers [27:44] - How DNA, blood, and fitness data combine to provide a full picture for health analysis [35:06] - Gil's perspective on wearables, continuous glucose monitors, and other fitness trackers [41:06] - The evolution of InsideTracker and personal health monitoring [44:53] - Differentiating between biological and chronological age with InsideTracker's InnerAge [49:25] - Gil's thoughts on how long humans in existing generations might live --- Support the show by checking out my sponsors: Join Levels and get personalized insights to learn about your metabolic health. Go to https://levels.link/jake. --- https://homeofjake.com

Aging is indexed by PubMed/Medline abbreviated as “Aging (Albany NY)”, PubMed Central, ISI/Web of Science: Science Citation Index Expanded (abbreviated as Aging‑US and listed in the Cell Biology category; since June 2017 it has also been listed in the Geriatrics & Gerontology category), and Scopus /Rank Q1 (abbreviated as Aging). Every year, the American Association for Cancer Research (AACR) organizes a conference program that covers the latest discoveries in cancer research. Topics include population science and prevention, cancer biology, translational and clinical studies, survivorship, and advocacy. This conference aims to highlight work from the best minds in research and medicine from institutions all over the world. The journal Aging, by Impact Journals, will be participating at the AACR Annual Meeting this year. Visit Aging website: https://www.aging-us.com/ Impact Journals is an open-access publisher of rigorously peer-reviewed scientific literature, and owns several medical research journals, including Aging. Aging was launched by Impact Journals in 2009 with the goal of spotlighting high-impact papers, authored by scientists who study the process of aging and age-related diseases—including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Visit Impact Journals website: https://www.impactjournals.com/ Aging has published outstanding papers and reviews by highly-cited authors and award winners, including Andrew V. Schally (Nobel Laureate), Shinya Yamanaka (Nobel Laureate), Lawrence Donehower, Toren Finkel, Stephen Helfand, Gerald Shadel, Andre Nussenzweig, Maurice Burg, Karen Vousden, Leonard Guarente, and Dale Bredesen. Importantly, the Aging Editorial Board also comprises numerous prestigious award winners, including Nobel Laureate Elizabeth H. Blackburn, and many other distinguished scientists, including Cynthia Kenyon, Judith Campisi, Leonard Guarente, Michael Hall, Mikhail Blagosklonny, Vera Gorbunova, David Sinclair, Jan Vijg, and Thomas Rando. The journal has recently concluded its 12th year of publishing and has become Impact Journals' featured journal. Learn more about Aging and Impact Journals at the virtual 2021 AACR conference on April 10-15 and May 17-21, 2021. Registration will be open through the beginning of the event. More About Aging Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways. Please visit our website at http://www.Aging-US.com​ or connect with us on: SoundCloud - https://soundcloud.com/aging-us Twitter - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ YouTube - https://www.youtube.com/agingus LinkedIn - https://www.linkedin.com/company/aging Aging is published by Impact Journals, LLC please visit http://www.ImpactJournals.com​ or connect with @ImpactJrnls Media Contact 18009220957 MEDIA@IMPACTJOURNALS.COM

What if you could slow down the clock on your aging? According to aging expert and Harvard geneticist, Dr. David Sinclair, we now have the knowledge and technology to live longer lives, healthier. In his revolutionary research, Dr. Sinclair has identified mechanisms behind aging giving us clues into the behaviors and molecules that can potentially extend life.  Listen and Learn: Why is aging a disease and how can it be slowed What are longevity genes and what role do they play in health What is epigenetics and how does it relate to aging and health What is hormesis and why is being too comfortable bad for our longevity What behavioral strategies can you start today that will lead to a longer life What molecules Dr. Sinclair’s lab is researching that could be our future fountain of youth What are the social and individual impacts of living longer with more health What does Dr. David Sinclair do each day to activate his longevity genes Resources: Lifespan: Why we age and why we don’t have to by David Sinclair The Harvard Study of Adult Development About David Sinclair David A. Sinclair, Ph.D., A.O. is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co-discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where he has been teaching aging biology and translational medicine for aging for the past 16 years. Dr. Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in five books, two documentary movies, 60 Minutes, Morgan Freeman’s “Through the Wormhole” and other media. He is an inventor on 35 patents and has received more than 25 awards and honors including the TIME magazine’s list of the “100 most influential people in the world”.

Listen to Leonard Guarente on Libsyn Network Tom speaks with Dr. Leonard Guarente about aging. Dr. Guarente is the chief scientist at Elysium Health and director. He’s studied aging for 30 years, and he and Tom speak about how the field is at a tipping point! The post Leonard Guarente appeared first on Boomers Rock.

Tom speaks with Dr. Leonard Guarente about aging. Dr. Guarente is the chief scientist at Elysium Health and director. He's studied aging for 30 years, and he and Tom speak about how the field is at a tipping point!     promo code- TMRadio for your first month of Basis free, a 50.00 value, may expire 2/29/2020 so jump on it!

SO I’VE BEEN THINKING ABOUT THE CONVERSATION **THAT WE DID NOT HAVE THE OTHER NIGHT** AND THE DINNER **THAT BILLY DID NOT COOK THE OTHER NIGHT-** WHAT WE DID THO - WAS GO OUT TO ONE OF THE LOCAL CHAIN RESTAURANTS, ALBEIT ONE OF THE BETTER ONES TO HAVE A HAMBURGER. IT WAS KINDA NICE TO HAVE THAT BREAK FROM ALL THAT GOURMET COOKING - ADMIRING BILLS TECHNIQUE IN CREATING OUTSTANDING MEALS, SOME OF WHICH ARE ORIGINAL, SOME OF WHICH ARE JUST BETTER VERSIONS OF THE ONES WE HAVE IN RESTAURANTS. BUT I DIGRESS. IT WAS WHILE EATING THE HAMBURGER THAT I WAS EAVESDROPPING AMONG THE GUESTS SITTING AROUND US WHEN I OVERHEARD AN INTERESTING CONVERSATION ONE MORE SENIOR WOMAN COMPLAINED THAT SHE HADN’T DONE HER MAKEUP, AND THE GENTLEMEN SITTING ACROSS FROM HER ( I CAN ONLY ASSUME THAT WAS HER HUSBAND SAID “SARAH, WHAT DO YOU NEED MAKEUP FOR - WHO ARE YOU TRYING TO ATTRACT AT YOUR AGE. AT WHICH TIME THE OTHER WOMAN AT THE TABLE SAID. WELL HONEY YOU ARE LUCKY - AT YOUR AGE YOU ARE FREE NOW, YOU DON’T NEED MAKEUP ANYMORE. AT WHICH TIME SARAH SAID - ITS NOT THE MAKEUP, BUT THE FACT THAT I FORGOT TO PUT IT ON. THERE WERE SO MANY THINGS TO UNPACK IN THAT CONVERSATION - VANITY, AGING, BRAIN FUNCTION - SO I THOUGHT I’D SEARCH OUT SOME TRULY REMARKABLE PEOPLE TO ADDRESS MANY OF THOSE ISSUES. SO THAT’S WHAT WE’LL YAK ABOUT TODAY.---   Let’s face it people in western society are vain. Looking good is almost mandatory. You walk down the street in the big cities and they are teaming with fit, well clothed people with skin that is silky smooth. But often you see some men and woman, looking a bit disheveled, glasses held up by the tip of the nose. no makeup (not homeless) I just assume that they are intellectuals, professors, scientists etc. WHO DON’T FALL INTO SOCIETIES EXPECTATIONS ON BEAUTY I’ve always wondered what do those people think about Vanity. So I went and searched out someone who could give us a point of view of what the cost of vanity is. # Scilla ELWORTHSCILLA ELWORTHY [Dare to Question Why We Are So Afraid of Getting Older: Scilla Elworthy at TEDxMarrakesh 2012 - YouTube](https://youtu.be/J6zenOjPC1A)https://youtu.be/J6zenOjPC1A is the founder of the Oxford Research Group, a non-governmental Organisation she set up in 1982 to develop effective dialogue between nuclear weapons policy-makers worldwide and their critics. She served as its executive director from 1982 until 2003, when she left that role in order to set up Peace Direct, a charity THA SUPPORTS local peace builders in conflict areas. From 2005 she was adviser to Peter Gabriel, Desmond Tutu and Richard Branson in setting up The Elders. She is a member of the World Future Council and the International Task Force on Preventive Diplomacy. She has been nominated three times for the Nobel Peace Price and in 2003 she was awarded the Niwano Peace Prize for her work with the Oxford Research Group. ------# DR. THAD POLK DR. DAVID POLK - AGING IS NOT WHAT YOU THINK[Aging: It’s Not What You Think | Thad Polk | TEDxUofM - YouTube](https://youtu.be/wrTIS0uKg6o)https://youtu.be/wrTIS0uKg6o   e often talk about memory loss as we age. We’ve learned the tricks to help us out. Just ask Brad Zupp, our memory athlete. As a result, common wisdom says that age isn’t too kind to our minds abilities. But can iT brain actually be improving as we age. So why not look for someone who can explain it. Our brains are powerful pieces of machinery that give us the capacity to do amazing things. Unfortunately, common wisdom says that age isn’t too kind to our minds’ abilities. Neuroscientist Thad Polk walks through the actual effects of aging on the human brain and shows that our assumptions might not be so accurate.Dr. Thad Polk has been a member of the University of Michigan psychology faculty since 1996. he was named an Arthur F. Thurnau Professor in recognition of outstanding contributions to undergraduate education, and in 2012 Princeton Review included him on its list of the Best 300 Professors in the US. ------ # David Andrew Sinclair DAVID SINCLAIR - SLOWING DOWN AGING [David Sinclair Slowing down Aging - YouTube](https://youtu.be/9bhDgBhRgtk) https://youtu.be/9bhDgBhRgtkDR. DAVID POLK - AGING IS NOT WHAT YOU THINK[Aging: It’s Not What You Think | Thad Polk | TEDxUofM - YouTube](https://youtu.be/wrTIS0uKg6o)https://youtu.be/wrTIS0uKg6o hile we are speaking of aging. You constantly here that there is research being done that will slow down the aging process or halt it altogether - God forbid you have to live with that difficult family member forever. I tried to find someone who can explain in simple terms - what research is being done to slow down the aging process. HIS NAME IS DAVID SINCLAIR AND HE is an Australian biologist and Professor of Genetics best known for his research on the biology of lifespan extension and driving research towards treating diseases of aging. Sinclair is Co-Director of the Paul F. Glenn Laboratories for the Biological Mechanisms of Aging at Harvard Medical School. Sinclair obtained a Bachelors of Science (Honours Class I) at the University of New South Wales, Sydney, and received the Australian Commonwealth Prize. In 1995, he received a Ph.D. in Molecular Genetics then worked as a postdoctoral researcher at the Massachusetts Institute of Technology with Leonard Guarente.Since 1999 he has been a tenured professor in the Genetics Department of Harvard Medical School. Sinclair has received over 25 awards including The Australian Commonwealth Prize, A Helen Hay Whitney Fellowship, the Nathan Shock Award, a Leukemia and Lymphoma Fellow, a MERIT Awards from the National Institutes of Health, the Merck Prize, the Arminese Fellowship, the Genzyme Outstanding Achievement in Biomedical Science Award, an Ellison Medical Senior Fellow, the Bio-Innovator award, the Bright Sparks Award for Top Scientists under 40, The Denham Harman Award in Biogerontology, a medal from the Australian Society for Medical Research, and a TIME 100 honoree, TIME magazine’s list of the 100 “most influential people in the world” (2014).———— ------# Jane Caro JANE CARO[Growing old: The unbearable lightness of ageing | Jane Caro | TEDxSouthBank - YouTube](https://youtu.be/ULqf3OyemZY)https://youtu.be/ULqf3OyemZY Jane Caro has a low boredom threshold and so wears many hats; including author, novelist, lecturer, mentor, social commentator, columnist, workshop facilitator, speaker, broadcaster and award winning advertising writer. The common thread running through her career is a delight in words and a talent for using them to connect with other people. @JaneCaro@TEDxSouthBank This talk was given at a TEDx event using the TED conference format but independently organized by a local community. Learn more at [http://ted.com/tedx](https://www.youtube.com/redirect?event=video_description&v=ULqf3OyemZY&q=http%3A%2F%2Fted.com%2Ftedx&redir_token=Tr5pUh70swXaZsz0iwgFjacJeTR8MTU2Mjg1NjU2MUAxNTYyNzcwMTYx) My tits don’t hurt: Ever ---- I want to thank our sponsor for making Yak About Today possible AND THE NUMBER ONE TALK RADIO STATION IN OUR MARKET. We couldn’t do half of what we do without them. But that wouldn’t mean much if we didn’t believe in them. To my mind and many others they are simply the best practice to go to for both prevention as well as more serious eye conditions. So like i always say - go see Drs. Minotti Rhinehour, tate and o’brien because i wouldn’t trust my eyes to anyone else --- DAVID SINCLAIR - SLOWING DOWN AGING [David Sinclair Slowing down Aging - YouTube](https://youtu.be/9bhDgBhRgtk) https://youtu.be/9bhDgBhRgtkDR. DAVID POLK - AGING IS NOT WHAT YOU THINK[Aging: It’s Not What You Think | Thad Polk | TEDxUofM - YouTube](https://youtu.be/wrTIS0uKg6o)https://youtu.be/wrTIS0uKg6o SCILLA ELWORTHY[Dare to Question Why We Are So Afraid of Getting Older: Scilla Elworthy at TEDxMarrakesh 2012 - YouTube](https://youtu.be/J6zenOjPC1A)https://youtu.be/J6zenOjPC1A JANE CARO[Growing old: The unbearable lightness of ageing | Jane Caro | TEDxSouthBank - YouTube](https://youtu.be/ULqf3OyemZY)https://youtu.be/ULqf3OyemZY   ----------------------------------------------------------------- # SOCIAL MEDIA STUFF#yakabouttoday/SOCIAL Social Media Attachment for all publications “YOU CANT GO BACK AND CHANGE THE BEGINNING BUT YOU CAN START WHERE YOU ARE AND CHANGE THE ENDING. The Yak About Today broadcasts deliver on air and online conversations, interviews and stories engaging the Baby Boomer Generation and beyond with discussions, tips and information. YOU CAN FIND US ON THE STATIONS WAXE 107.9, WZTA 1370 AM AND REAL RADIO 101.7 IN FLORIDA AND OF COURSE ON ALL MAJOR PODCASTING SYSTEMS.YOU CAN ALSO GET US AT YAKABOUTTODAY.COM AND FACEBOOK AND TWITTER AND ALL SOCIAL PLATFORMS, JUST LOOK FOR YAK ABOUT TODAY. OR WRITE ME AT YAKABOUTTODAY@GMAIL.COM Hosted by an authentic conversationalist, intuitive listener and a boomer himself, David Yakir brings a genuine, down to earth and disarming personality that talks with his audience and his guests with out talking at them. David shares Engagement, Education, Enjoyment & Empowerment on air and online for the BabyBoomer Generation delivered with humor, wit and thought. Yak About Today is your GPS guide for technology, fitness, , finance entrepreneurship, entrepreneurship & all things that mean anything to you. 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http://RunningAFEVER.com In the 1980's, Leonard Guarente began doing anti-aging research at MIT. He's a biologist, and his major discovery was finding a gene that controls aging by experimenting with yeast. Subsequent supporting research has been done on rats as well. In the 1980's, Leonard Guarente began doing anti-aging research at MIT. He's a biologist, and his major discovery was finding a gene that controls aging by experimenting with yeast. Subsequent supporting research has been done on rats as well. There are 2 important substances at work here. Sirtuins, a protein that regulates aging and other processes at a cellular level. We need them particularly to make nicotinamide adenine dinucleotide (NAD+), a required material for conversion of food into energy and other cell functions. NAD supplies in the body deteriorate over time, though some can come can be gained from certain food substances like tryptophan, aspartic acid and niacin. From this comes the idea of supplementation. A couple of companies have been formed by the scientists involved in these discoveries including Dr. Guarente. Elixir Pharmaceuticals, now defunct, was to develop drugs. Dr. Guarente co-founded Elysium Health in 2014, this time to market supplements. Elysium has already produced a product capitalizing on the research, Basis, which is claimed to support higher NAD levels to slow the aging process. They recommend 2 caps per day, and you can subscribe at the website for $50/month. The thing about supplements is that no real proof that they work is required. Only marketing and producing a belief that they work. And in this case, when will you going to know that it helped you live longer? After you've spend thousands of dollars for how many years? This market is expected to be almost $125 Billion by 2023. In the US Alone, it was $42B in 2016. Elysium has done clinical trials, double-blind studies with placebo control groups. Basis is also Certified for Sport by the National Science Foundation. There are a lot of "this could be the secret to aging better" articles, but the jury is still out. The best advice I can give is what I say about everything: be an expert in your own health, do the research and make your choices based on that. Sources: https://www.goodhousekeeping.com/health/a25642740/elysium-health-basis-pill/ https://en.wikipedia.org/wiki/Leonard_P._Guarente https://en.wikipedia.org/wiki/Sirtuin https://www.openpr.com/news/1490885/Anti-Ageing-Drugs-Market-2019-Analysis-Research-Covers-Top-10-Players-as-BIOTIME-INC-Elysium-Health-Inc-La-Roche-Posay-DermaFix-L-OR-AL-and-others.htmlhttps://www.inverse.com/article/49550-three-letters-could-change-everything Recorded January 21, 2019. Weight (change since Jan 2018): 200 (-74) Workout time:  108 Minutes Total Distance (total since Nov 2017): 7.46 Miles (394.48) Steps: 16,367 Muscle Mass (change since Aug 2018): 145.38 (+2) Body Fat: 27.2% Daily Sleep Duration 7-day Avg: 6 hours 2019 Goal: 15% Body Fat

Matt Kaeberlein – Longevity Expert Our guest today is Matt Kaeberlein, Ph.D., a globally recognized researcher and expert in the biology of aging. Dr. Kaeberlein’s research is based around the premise that understanding the molecular mechanisms of aging will lead to interventions that slow the onset and progression of age-related chronic conditions, such as cancer, diabetes, kidney disease, heart disease, Alzheimer’s and others. Dr. Kaeberlein received his Ph.D. from the Massachusetts Institute of Technology in 2002 advised by Leonard Guarente, and did his post-doctoral work with Stanley Fields in the Department of Genome Sciences at the University of Washington. Dr. Kaeberlein’s expertise in dietary restriction, longevity genes for therapeutics, aging in dogs, and Rapamycin really shines in this conversation. We were lucky enough to really explore his background while sharing our collective love of dogs. The conversation explores many areas, including: What is the difference between calories restriction and dietary restriction What are the biggest challenges with the science How Matt thinks about tailored dietary advice Why Matt launched the Dog Aging Project What we can learn from his research with dogs What is Rapamycin and why he’s so interested in its effects This conversation was incredibly illuminating and really fun. We hope you enjoy the episode and share it with your friends, family, and colleagues. About Matt Matt Kaeberlein Matt Kaeberlein Twitter Show Links Next Generation sequences Metabolomics Epigenetic clocks Calorie Restriction Society TAME Trial Rapamycin Daniel Promislow Dog Aging Project Acarbose NIA Interventions Testing Program Shock center of excellence George M. Martin Rapalog Everolimus

In this episode, David A. Sinclair, Ph.D., a Professor in the Department of Genetics at Harvard Medical School and co-Director of the Paul F. Glenn Center for the Biological Mechanisms of Aging, provides insight into why we age and how to slow its effects based on his remarkable work on the role of sirtuins and NAD in health and diseases. He also presents the case that stabilizing the epigenetic landscape may be the linchpin in counteracting aging and disease.  We discuss: How and why David moved from Australia to Leonard Guarente’s lab at MIT [7:30]; Sirtuins and aging [15:00]; A series of experiments elucidating the mechanisms of sirtuins [20:45]; How are sirtuins activated? [25:30]; NAD and sirtuin activation [31:00]; Nicotinamide, sirtuin inhibition, andPNC1 [39:00]; Resveratrol [43:00]; The NIH/ITP studies on resveratrol [55:45]; Does David take any compounds for longevity? [1:00:15]; NAD precursors (NR, NMN) and pterostilbene [1:02:45]; Female fertility and NAD precursors [1:14:45]; A unifying theory of aging [1:20:30]; Waddington’s epigenetic landscape [1:23:00]; If David had unlimited resources, what is the experiment he would do? [1:28:25]; Testing combinations to extend lifespan [1:31:30]; What made David aware of his mortality at such a young age? [01:33:45]; What is David’s book going to cover? [01:37:15]; and More. Learn more at www.PeterAttiaMD.com Connect with Peter on Facebook | Twitter | Instagram.