Podcast appearances and mentions of Dave Asprey

Most people track glucose or ketones, but almost no one is measuring the hidden signal that could be silently wrecking your metabolism, brain function, and longevity: uric acid. This episode reveals why this overlooked biomarker drives obesity, diabetes, cardiovascular disease, Alzheimer's, and even accelerated aging—and how you can hack it to unlock resilience, human performance, and smarter not harder health upgrades. Watch the podcast on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR We revisit host Dave Asprey sitting down with Dr. David Perlmutter, one of the world's leading functional medicine neurologists and the #1 New York Times bestselling author of Grain Brain and Drop Acid. Dr. Perlmutter has spent decades connecting gut health, brain optimization, and neuroplasticity with lifestyle interventions that truly change the trajectory of disease. In this conversation, he explains how uric acid acts as a metabolic switch that determines whether you burn fat or store it, whether your mitochondria power you up or slow you down, and whether your brain stays sharp or declines with age. They break down how fructose, purines, alcohol, and even dehydration spike uric acid, why Japan is decades ahead in using this as a health marker, and how supplements like quercetin and luteolin rival pharmaceuticals in keeping it under control. You'll also learn how ketosis, fasting, cold therapy, carnivore and plant-based approaches, and sleep optimization all interact with uric acid to shape your healthspan. This is biohacking at its most actionable—because once you measure this signal, you can control it, and once you control it, you radically upgrade your metabolism, your brain, and your longevity. This is essential listening for anyone serious about hacking their biology, building neuroplasticity, powering up mitochondria, exploring nootropics, and discovering smarter not harder ways to live longer and perform better. You'll Learn: • Why uric acid may be the most important overlooked biomarker for longevity • How it connects obesity, diabetes, cardiovascular disease, and Alzheimer's • The evolutionary reason your body uses uric acid as a survival signal • How fructose and hidden sugars sabotage metabolism and brain optimization • The role of quercetin, luteolin, and targeted supplements in lowering uric acid • Why measuring at home with a simple device can change your health trajectory • How functional medicine uses uric acid as a predictive tool for chronic disease Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: uric acid longevity, uric acid metabolism, fructose uric acid pathway, xanthine oxidase inhibition, quercetin uric acid, luteolin supplements, AMP kinase uric acid, AMP deaminase metabolism, uric acid and mitochondria, uric acid and neuroplasticity, uric acid Alzheimer's risk, uric acid dementia prevention, uric acid and nitric oxide, fructose metabolism hibernation biology, evolutionary mismatch uricase mutation, fructokinase inhibition, uric acid and insulin resistance, gout biohacking, uric acid and obesity, uric acid functional medicine Resources: • David's Website: https://drperlmutter.com/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 0:35 — Introduction 2:26 — Why Uric Acid Matters 5:55 — Measuring Uric Acid 8:17 — Disease Risk 9:38 — Metabolism Disruption 15:59 — What Raises Uric Acid 26:20 — Global Research 29:50 — Gut & Inflammation 32:55 — Seasonal Eating 47:36 — Brain Health 56:38 — Supplements & Testing 61:45 — The LUV Diet 71:41 — Closing Insights See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Mike Koenigs is a serial entrepreneur, bestselling author, and media strategist who has founded and sold multiple companies to publicly traded firms. He's the author of Your Next Act and The AI Accelerator, and has written over a dozen bestselling books. Mike co-hosts the podcasts Capability Amplifier with Dan Sullivan and The Big Leap with Gay Hendricks. A cancer survivor and sought-after speaker, he's worked with leaders like Tony Robbins, Peter Diamandis, and Dave Asprey to help entrepreneurs reinvent themselves and build businesses they love.Connect with Mike:https://aiaccelerator.com/Get your Free copy of AI Accelerator Book:https://aiaccelerator.mikekoenigs.com/free/Get your Free copy of Your Next Act Book MikeKoenigs.com/free-----------------------------------------------------------Get Your Free Unstoppable Confidence Module from Peak Life OS: https://confidence.peakhumans.io/Start your day right with AG1, packed with 75 high-quality ingredients that support gut health and overall performance. Get a FREE 1-year supply of Vitamin D and 5 free AG1 Travel Packs with your first purchase. ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠drinkAG1.com/naeem⁠⁠⁠⁠⁠⁠Welcome to Peak Humans with Naeem Mahmood, founder of Peak Humans and a world-renowned peak performance coach, keynote speaker, and expert in leadership, organizational behavior, psychology of achievement, and sales mastery. Previously a top coach for Tony Robbins, Naeem has delivered over 1,000 talks and trainings across the United States, impacting over 50,000 lives.Connect with Naeem:Instagram:⁠⁠ ⁠https://www.instagram.com/iamnaeemmahmood/⁠⁠⁠X:⁠⁠ ⁠https://x.com/NaeemMahmood⁠

Your dopamine system is being hijacked every day, and the way to reclaim it might surprise you. This episode reveals how pain, pleasure, and addiction are wired in your brain, and how to use that knowledge for real brain optimization, resilience, and longevity. You'll discover why your dopamine levels control motivation, focus, mood, and even cravings—and the science-backed strategies that reset your neuroplasticity, metabolism, and reward system. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Anna Lembke, Stanford psychiatrist and bestselling author of Dopamine Nation. She is one of the world's leading experts on addiction, compulsive behavior, and the neuroscience of reward pathways. With decades of clinical work and groundbreaking research, she explains why dopamine has become the modern lens for understanding desire, distraction, and dysfunction—and how we can hack it to upgrade human performance. They break down how dopamine drives addiction, why pain can reset your reward system, and how simple practices like fasting, cold therapy, and supplements affect your brain chemistry. You'll learn how nicotine, GLP-1 drugs, and even nootropics alter dopamine sensitivity, and why overstimulation from social media, pornography, and ultra-processed food is creating an epidemic of anhedonia. The conversation also covers how functional medicine and biohacking can protect your mitochondria, restore your natural dopamine balance, and make your brain more resilient. You'll Learn: • Why dopamine itself is not addictive—and what really drives addiction • How pain, hormesis, and “dopamine fasting” can reset your reward system • Why social media and digital overstimulation create chronic dopamine deficit states • The role of GLP-1 drugs, nicotine, psychedelics, and other substances in rewiring dopamine • How functional medicine and supplements help restore dopamine balance • The connection between dopamine, mitochondria, fasting, cold therapy, and longevity • Why radical honesty and self-binding are powerful anti-addiction hacks This is essential listening for anyone serious about hacking dopamine for better focus, sleep optimization, metabolism, and long-term brain health. Whether you're curious about the link between dopamine and neuroplasticity, looking to upgrade human performance with smarter not harder tools, or just want to know how to stop dopamine hijacks from ruling your life, this episode gives you the science and strategies you need. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: dopamine fasting, pleasure-pain balance, dopamine deficit state, addiction neurobiology, anhedonia treatment, dopamine receptors, neuroadaptation gremlins, endogenous opioids, cold plunge dopamine, hormesis neuroscience, nucleus accumbens dopamine, L-Dopa addiction, GLP-1 and dopamine, social media addiction neuroscience, dopamine reward pathway, compulsive behavior psychiatry, dopamine and neuroplasticity, anhedonia supplements, functional medicine addiction, dopamine repair party Thank you to our sponsors! Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • Anna's Website: https://www.annalembke.com/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:10 — Introduction 5:47 — Pleasure–Pain Balance 6:45 — Homeostasis & Adaptation 8:22 — Addiction & Dopamine Deficit 10:14 — BICEP: Conscious Pain Exposure 14:26 — Adapting to Pleasure & Pain 20:20 — GLP-1s and Joy 21:39 — Modern Anhedonia 34:32 — Resilience in Young People 42:00 — Social Media & Mental Health 44:46 — Control & Addiction 55:14 — Dopamine Fasting 1:03:18 — Self-Binding Tools 1:07:56 — Psychedelics & Addiction 1:12:25 — Parenting in the Digital Age 1:14:39 — Progress & Outlook See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Alzheimer's is not inevitable—and it may even be optional. In this groundbreaking episode, you'll learn how to prevent, slow, and in some cases reverse cognitive decline using strategies that also enhance brain optimization, metabolism, and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Dr. Dale Bredesen, a world-renowned neurologist and leading Alzheimer's researcher who has published over 240 peer-reviewed papers. Dr. Bredesen has spent decades proving that Alzheimer's is not a one-pathway disease but a network failure driven by inflammation, toxins, and mitochondrial dysfunction. His protocol has helped thousands of patients regain memory, extend healthspan, and reclaim brain performance. Together, they unpack how biohacking tools like fasting, ketosis, supplements, sleep optimization, cold therapy, and functional medicine can rewire neuroplasticity, protect mitochondria, and keep the brain in “connection mode” instead of decline. You'll hear why the pharmaceutical industry resists these solutions, how toxins like Paraquat and mold fuel cognitive decline, and what young people can do right now to bulletproof their brains for life. This episode is essential listening if you care about hacking human performance, upgrading metabolism, or extending longevity. You'll walk away with practical strategies you can use today—whether that means optimizing your mitochondria with nootropics, strengthening resilience with smarter not harder recovery, or fueling your brain with Danger Coffee. You'll Learn: • Why Alzheimer's can begin as early as your 20s and what biomarkers to track • The seven major drivers of Alzheimer's and how to reverse them with biohacking strategies • How APOE4 genetics, toxins, and inflammation accelerate brain aging—and what to do about it • The role of mitochondria, ketosis, and fasting in restoring brain optimization and neuroplasticity • Why prevention is exponentially easier than reversal and the top three actions you should start in your 20s • How to avoid “learned helplessness” in medicine and reclaim control over your brain span and longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Alzheimer's prevention biohacking, APOE4 genetics risk, mitochondrial dysfunction brain, network insufficiency model, cognitive decline reversal protocol, neuroplasticity longevity strategies, mild cognitive impairment treatment, subjective cognitive impairment biomarkers, ketoflex 12/3 diet, mycotoxins and Alzheimer's, Paraquat Parkinson's risk, mitochondrial transfusion therapy, fasting neuroprotection, ketosis brain optimization, natokinase soft plaque removal, sleep apnea cognitive decline, functional medicine Alzheimer's, hippocampal volume preservation, nootropics cognitive resilience, learned helplessness medicine Thank you to our sponsors! EMR-Tek | Go to https://www.emr-tek.com/DAVE and use code DAVE for 40% off.fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. Resources: • Dale's Website: https://www.apollohealthco.com/dr-bredesen/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:10 — Introduction 2:43 — Personal Story 7:52 — APOE4, Genetics, and Drug Development 11:37 — Pharma, Media, and Pushback 17:13 — Prevention, Stages, and Biomarkers 23:34 — Causes and Mechanisms 30:24 — Parkinson's, Toxins, and Mitochondria 37:17 — Longevity, Biohacking, and Protocols 44:11 — AI, Data, and Future Treatments 54:11 — Case Studies and Success Stories 1:03:00 — Detox, Mold, and Environmental Triggers 1:12:00 — Neuroplasticity and Brain Regeneration 1:20:00 — Hormones, Supplements, and Personalized Hacks 1:29:00 — Cortisol, Addison's, and AI Protocols 1:38:00 — Large-Scale Trials and Global Impact 1:45:00 — Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In today's episode, I sit down with Dave Asprey, entrepreneur, author, and widely regarded as the father of biohacking. We talk about his new book Heavily Meditated and the tools he's developed to help people reset their nervous systems, dissolve stress, and unlock inner peace. Dave explains how triggers are programmed into our bodies and how we can shut off the ones that no longer serve us. He also shares why recovery is often more important than stress itself, the science of sleep and jet lag, and why time as we know it may be an illusion.

Your hormones may be waging a hidden war that determines how long you live and how well you perform. This episode reveals how male and female biology diverge—and what those differences mean for your longevity, metabolism, and brain optimization. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Revisit this episode where Dave Asprey sits down with Teal Swan, a bestselling author and international speaker known for her work on human behavior, healing, and consciousness. Her insights bridge biology and psychology, uncovering how hormones, trauma, and environment shape both performance and resilience. Her ability to decode patterns of narcissism, victimhood, and trust through the lens of functional medicine and human performance makes her one of the most provocative voices in personal transformation. Together, they explore the science behind the hormonal divide between men and women—why birth control alters not just fertility but also male testosterone, why perception and neurodivergence impact neuroplasticity, and how early trauma imprints mitochondria and metabolism. You'll learn how fasting, ketosis, cold therapy, sleep optimization, and smarter not harder strategies can shift your biology toward higher resilience and greater longevity. They also break down the biohacking tools and supplements that can help balance hormones, upgrade mitochondria, and fuel nootropics-level brain performance. From the hidden biological costs of hormonal birth control to how carnivore and targeted nutrition affect both male and female healthspan, this episode gives you a framework for hacking your biology at the deepest level. This is essential listening for anyone serious about biohacking, hacking human performance, brain optimization, functional medicine, or understanding how masculine and feminine biology directly influence lifespan and resilience. You'll Learn: • How hormonal birth control impacts both women's fertility and men's testosterone • Why victim mentality rewires the brain and reduces neuroplasticity • How narcissism functions as a biological stress adaptation • The role of mitochondria, metabolism, and trauma in shaping healthspan • How fasting, ketosis, supplements, and cold therapy affect hormone balance • Why balancing male and female energetics may be a key to longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: hormone war, male vs female longevity, hormonal birth control effects, testosterone collapse, estrogen disruption, masculine vs feminine biology, victim mindset neuroscience, narcissism as adaptation, betrayal and biology, neuroplasticity and trauma, perception and neurodivergence, fractal vision, birth trauma programming, mitochondria and stress, species-level hormone imbalance, industrial hormone disruption, male fertility decline, female hormone resilience, functional medicine hormones Resources: • Teals Website: https://tealswan.com/ • Teal's YouTube: https://www.youtube.com/@TealSwanOfficial • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Cold Open 0:33 — Intro 2:49 — Defining Narcissism 5:48 — Gender Differences in Narcissism 7:47 — AI, Humanity, and the Future 10:25 — Extrasensory Perception & Childhood Experiences 14:04 — Birth Memories and Early Trauma 17:57 — Spiritual Abilities and Neurodivergence 22:48 — Functioning in the World with Unique Perceptions 23:45 — Trust, Support, and Creation 30:07 — Ego, Consciousness, and Spiritual Guides 33:46 — Dimensions and Multiverse Concepts 36:52 — Divine Masculine & Feminine 40:25 — Societal Imbalances and Gender Energies 46:20 — Hope for Humanity & Utopia 48:36 — Synchronization Workshops & Group Healing 51:30 — Science, Energy, and Invisible Communication 53:29 — Conclusion & Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Walking speed predicts your risk of death better than cholesterol—and this episode reveals why. You'll learn how to test your biological age at home in just 10 seconds, and how to use that information to upgrade your human performance, extend your longevity, and tailor your biohacking strategy for maximum results. Discover the overlooked role of pelvic floor strength, glute activation, and neuromuscular training in brain optimization, metabolism, and injury prevention. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey speaks with Dr. Vonda Wright, a double board-certified orthopedic surgeon, hormone optimization expert, and elite sports medicine pioneer who's worked with Olympic athletes, military special forces, and high-performing women through every phase of life. With decades of experience in functional medicine, movement science, and hormone therapy, Dr. Wright shares the essential strategies to prevent frailty, rebuild strength, and thrive through perimenopause and beyond. You'll learn: • How walking speed reveals aging and longevity better than traditional blood tests • The biomechanics behind muscle “shutdown” and how to turn muscles back on • The truth about C-sections, pelvic floor rehab, and functional motion assessments • Which supplements, nootropics, and hormone therapies restore metabolism and vitality • Why perimenopause is a turning point for brain, bone, and cardiovascular health • Testing tools and training methods to upgrade strength, prevent falls, and age powerfully Whether you want to feel stronger, think sharper, or stay youthful into your 90s, this is your roadmap for smarter not harder biohacking with real-world impact. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: 10-second walk test longevity, pelvic floor dysfunction and aging, glute activation for brain health, perimenopause hormone replacement therapy, VO2 max biohacking, estrogen for bone density, neuromuscular reactivation exercises, functional movement assessment AI, post-C-section core recovery, velocity training for longevity, strength vs muscle mass aging, menopause testosterone therapy, mitochondrial health for women, sleep optimization progesterone, cold therapy for muscle recovery, fascia training for anti-aging, diastasis recti long-term effects, smart exercise hacks for aging, hormone optimization for libido and brain, smarter not harder fitness protocols Thank you to our sponsors! Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. Resources: • Vonda's Website: https://www.drvondawright.com/ • Vonda's Instagram: https://www.instagram.com/drvondawright/?hl=en • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer1:23 — Intro2:55 — Muscle Atrophy and Reactivation6:10 — Pelvic Floor Health and Rehab8:47 — Joint Mobility and Movement10:02 — Science of Muscle Function18:23 — Perimenopause and Menolescence27:58 — Four Essential Female Hormones42:50 — VO2 Max and Longevity49:24 — Velocity Training and Bone Health62:30 — Turning Menopause into Power65:58 — Closing Thoughts and Book Rec See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week's episode of Health Theory is a special about the benefits of the ketogenic diet. In this episode, multiple experts including Dave Asprey, Dom' D'Agostino and Ken Berry, share their knowledge about the Ketogenic Diet so that you have the most important facts all in one place. [ORIGINAL AIR DATE: 3-28-19]. SHOW NOTES What is the keto diet? [00:32] The cholesterol myth [03:38] What to eat on a keto diet [06:45] How to know if keto is right for you [15:41] SUPPORT OUR SPONSORS: Get 5 free AG1 Travel Packs and a FREE 1 year supply of Vitamin D with your first purchase at https://impacttheory.co/AG1pod. Secure your digital life with proactive protection for your assets, identity, family, and tech – Go to https://impacttheory.co/aurapod to start your free two-week trial. ********************************************************************** What's up, everybody? It's Tom Bilyeu here: If you want my help... STARTING a business: Join me inside ZERO TO FOUNDER here SCALING a business: Click here to see if you qualify Get my battle-tested strategies and insights delivered weekly to your inbox: sign up here. ********************************************************************** Join me live on my Twitch stream. I'm live daily from 6:30 to 8:30 am PT at www.twitch.tv/tombilyeu ********************************************************************** LISTEN TO IMPACT THEORY & MINDSET PLAYBOOK AD FREE + BONUS EPISODES on APPLE PODCASTS: apple.co/impacttheory ********************************************************************** FOLLOW TOM: Instagram: https://www.instagram.com/tombilyeu/ Tik Tok: https://www.tiktok.com/@tombilyeu?lang=en Twitter: https://twitter.com/tombilyeu YouTube: https://www.youtube.com/@TomBilyeu Learn more about your ad choices. Visit megaphone.fm/adchoices

Learn how to slow, and even reverse, your biological age with cutting-edge science on the molecule that controls your longevity. Host Dave Asprey sits down with Dr. Leonard Guarente, an MIT PhD and one of the most respected longevity researchers in the world, to reveal how NAD+, sirtuins, and DNA methylation clocks can help you hack aging, upgrade your mitochondria, and extend your healthspan. This episode gives you the real science, proven by over 250 studies, behind supplements, nutrition, and biohacking tools that actually work for brain optimization, metabolism, and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll learn why NAD+ is a master regulator of mitochondrial health, how DNA methylation clocks accurately measure biological age, and why boosting sirtuin activity improves resilience, neuroplasticity, and recovery. Dr. Guarente shares insider strategies from decades of functional medicine research, including nootropics, targeted supplements, fasting protocols, and diet adjustments from carnivore to Mediterranean that can shift your metabolism toward longevity. Dave and Dr. Guarente explore advanced biohacks like cold therapy, sleep optimization, and ketosis, plus how to balance these interventions with your genetics, lifestyle, and health goals. You'll also hear about the surprising role of homocysteine in brain aging, how to use lab testing to guide your longevity plan, and why resilience is the ultimate measure of health. You'll learn: • How emotional repression affects brain function, metabolism, and decision-making • Tools for nervous system regulation and emotional healing that drive high performance • Why most people fail without emotional intelligence and internal safety • How somatic awareness can optimize your energy, focus, and relationships • The science of fear, trauma release, and how to turn discomfort into growth • How to coach yourself out of stress, shame, and negative self-talk Whether you want to sharpen your brain, protect your heart, or upgrade your energy systems, this is a masterclass in smarter not harder biohacking for a longer, higher-performing life.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: NAD+ supplementation, Sirtuin activation, DNA methylation clocks, Biological age testing, Mitochondrial biogenesis, Epigenetic reprogramming, Pterostilbene benefits, Nicotinamide riboside (NR), Nicotinamide mononucleotide (NMN), Homocysteine reduction, Oxidative stress repair, Superoxide dismutase (SOD) activation, Functional medicine longevity, Healthspan optimization, Resveratrol bioavailability, Menopause mitochondrial support, Phenylbutyrate and protein folding, High-fat diet longevity studies, Neurodegenerative disease biohacking, INCHIANTI aging study Thank you to our sponsors! Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Elysium Website. Use code ‘UPGRADE25' for 25% off the first month of a monthly subscription to any Elysium supplement: https://www.elysiumhealth.com/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction to NAD & Sirtuins 0:59 — Intro 7:04 — Animal vs Human Aging Studies 10:07 — Discovery of Sirtuins 14:43 — NAD's Role in Aging 15:34 — Resveratrol vs Pterostilbene 23:13 — Timing NAD Supplementation 36:34 — Diet & Lifestyle Factors 50:05 — Elysium's Basis & Signal 1:00:03 — Future Clinical Trials 1:05:14 — Psychology of Aging & Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How do you activate your body's natural repair system? How can you hack stem cells for faster recovery, brain optimization, and peak human performance? This episode reveals how to trigger stem cell release, direct them to the right tissues, and stack biohacking tools for maximum regeneration. You'll learn science-backed strategies for boosting mitochondria, enhancing neuroplasticity, and extending longevity through targeted supplements, fasting, and functional medicine techniques. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Christian Drapeau, a leading stem cell scientist and founder of STEMREGEN. Christian's decades of research have transformed our understanding of how stem cells repair the body, reverse damage, and amplify performance. He shares practical protocols to mobilize stem cells, improve microcirculation, and reduce inflammation so your body heals faster, functions better, and stays younger for longer. You'll learn: • How stem cells rebuild muscle, brain, and organ tissue for optimal human performance • Why fasting rejuvenates bone marrow and increases stem cell effectiveness • The synergy between PEMF, vibration therapy, cold therapy, and stem cell activation • How microcirculation and inflammation control improve longevity and recovery • The best supplements and nutrients to support mitochondria and stem cell health • How to stack nootropics, ketosis, and brain optimization tools for lasting energy and focus This is essential listening for anyone serious about biohacking, longevity, human performance, mitochondria health, neuroplasticity, functional medicine, fasting protocols, supplements for recovery, brain optimization, smarter not harder healing, metabolism upgrades, cold therapy stacks, and next-level physical and cognitive resilience Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: STEMREGEN, biohacking, natural stem cell activation, human performance, longevity, mitochondria, neuroplasticity, fasting, bone marrow rejuvenation, functional medicine, supplements, brain optimization, metabolism, cold therapy, microcirculation, nootropics, ketosis, smarter not harder, recovery hacks Resources: • STEMREGEN Website: https://www.stemregen.co/dave for 20% off your first order. • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:00 — Why Some People Regenerate Better 1:52 — Testing Stem Cell Levels 2:58 — Natural Stem Cell Function 3:59 — Exercise & Stem Cell Response 5:13 — Tissue Turnover & Regeneration 7:03 — Bone Marrow Production 8:16 — Fasting & Bone Marrow 9:33 — Nutrition for Bone Marrow 11:14 — Traditional Meets Modern Science 12:58 — Training Bone Marrow 13:57 — Stem Cells as Repair System 34:20 — Stem Cells & Brain Injury 47:01 — Inside STEMREGEN Products 55:41 — Stress, Cortisol & Stem Cells 58:12 — Final Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How do you make tough decisions? How do you make them without fear or lying? This episode shows you how unresolved emotions disrupt decision-making, relationships, and functioning in peak brain performance. You'll learn tips to rewire your nervous system for decision making, optimizing emotional intelligence, and regulating your body for high-level clarity, energy, and resilience. Discover biohacking techniques that use emotional release and somatic awareness to boost mitochondria, activate neuroplasticity, and achieve lasting personal transformation. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Joe Hudson, a world-renowned executive coach to unicorn founders and billion-dollar leaders. Joe works with a select group of top performers to unlock emotional clarity, leadership mastery, and deep personal change. His methods combine neuroscience, trauma healing, somatic therapy, and conscious coaching to help people perform at their highest level while becoming more authentic, fulfilled, and connected.You'll learn:• How emotional repression affects brain function, metabolism, and decision-making • Tools for nervous system regulation and emotional healing that drive high performance • Why most people fail without emotional intelligence and internal safety • How somatic awareness can optimize your energy, focus, and relationships • The science of fear, trauma release, and how to turn discomfort into growth • How to coach yourself out of stress, shame, and negative self-talk This is essential listening for anyone serious about emotional intelligence, high-performance coaching, biohacking, somatic healing, trauma work, executive leadership, nervous system regulation, brain optimization, functional medicine, and building unstoppable inner resilience. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Joe Hudson, Dave Asprey, emotional intelligence, nervous system regulation, somatic therapy, trauma healing, executive coaching, biohacking emotions, brain optimization, emotional mastery, making tough decisions, fear or failure, leadership development, negative self talk, childhood trauma, personal transformation, smarter not harder, stress relief tools, leadership listening Thank you to our sponsors! Puori | Head to http://puori.com/dave for 20% off, including subscriptions. Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order. Resources: • Sign up for a complimentary transformation guide from Joe: https://www.artofaccomplishment.com/ • Joe's Art of Accomplishment Podcast: https://open.spotify.com/show/6MjoHFfLmNgo0Msais7IJ2 • Daily Insights on Twitter: https://tinyurl.com/4kazb783 • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction 2:42 — Why We Struggle with Fasting 6:28 — Identity and Control Patterns 11:56 — The Nervous System and Decision-Making 23:33 — Letting Go vs. Forcing Change 28:09 — Rebuilding Every Organ with Anti-Aging Work 33:51 — How to Actually Feel Emotions (Without Getting Stuck) 39:18 — Upgrading the Subconscious 45:02 — Final Thoughts and Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Toxins you cannot see are damaging your health, wrecking your metabolism, and quietly accelerating aging. This episode reveals how to detect the new poisons lurking in your home, how they sabotage mitochondria and brain optimization, and the biohacking fixes that restore longevity, energy, and human performance. You'll learn actionable strategies you can implement right away, from functional medicine detox protocols to supplements that protect your nervous system and upgrade neuroplasticity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Alan Bell, an environmental health attorney and author of POISONED. Alan's landmark legal work and decades of investigative experience have exposed some of the most dangerous everyday chemicals in modern life. After surviving his own severe toxic exposure, he's dedicated his career to helping others identify hidden threats, fight back against corporate negligence, and restore their health through targeted biohacking and functional medicine. You'll learn: • The most common invisible poisons in homes and how they impact metabolism, mitochondria, and brain optimization • Biohacking techniques for detox, from supplements to fasting and cold therapy • How to protect longevity and human performance with targeted functional medicine strategies • Why your sleep optimization, ketosis, and nootropics stack may fail without toxin removal • The connection between environmental toxins, neuroplasticity, and emotional resilience • How to use smarter not harder thinking to upgrade your biology for the long term This is essential listening for anyone serious about biohacking, brain optimization, hormone hacking, nootropics, functional medicine, emotional resilience, and building a state of unstoppable energy. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: Alan Bell, Dave Asprey, environmental illness, toxic building syndrome, VOC exposure, multiple chemical sensitivity, U.S. chemical safety laws, environmental toxins, mast cell activation, mitochondrial health, ten most dangerous chemicals, biohacking detox, air filtration, flame retardant-free bedding, non-toxic cookware, chronic illness Thank you to our sponsors! OneSkin | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Alan's Website: https://alanbell.me/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:07 — Intro 3:45 — Life in a Bubble 5:40 — Building Syndrome Impact 7:04 — Legal Gaps 11:55 — Medical Blind Spots 13:04 — Chemicals + Mold 14:00 — Legal Barriers 17:15 — Environmental Disease Links 18:54 — Toxic Burden 20:53 — Media Awareness 21:55 — Hollywood Hazards 24:00 — MCS & Fibromyalgia 26:04 — Recovery Strategies 27:22 — Mast Cell Science 38:15 — Biohacking & AI 40:17 — Top 10 Chemicals 44:00 — Reduce Exposure 48:45 — Detox & Travel 50:20 — Legal + Media Power 52:33 — Chemical Industry Truth 56:19 — Policy & Advocacy 58:12 — Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Want to think faster, remember more, and rewire your brain for high performance? This special archived episode breaks down the real nootropic stack, neuroplasticity tools, and brain optimization protocols Jim Kwik uses daily, plus the biohacking routines that rebuilt his cognition after traumatic brain injury. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with world-renowned brain coach Jim Kwik, bestselling author of Limitless and advisor to billionaires, athletes, and Hollywood performers. After being labeled “the boy with the broken brain” as a child, Jim transformed his life through functional medicine, nootropics, cold therapy, neurorehab, and smart supplementation. He's now the go-to expert on learning how to learn, with cutting-edge insights on memory, speed reading, focus, and cognitive recovery. Together, they reveal the most effective supplements for brain optimization, how to stack smart drugs with sleep optimization, the surprising downside of alpha GPC, and why things like ketosis, mitochondrial support, and even Danger Coffee are essential for modern cognition. You'll also hear why your brain speed depends on your metabolism, the forgotten science of post-traumatic growth, and how to combine breathing, fasting, and cold therapy for massive neuroplasticity gains. Jim also shares his Brain Animal system, a new way to personalize your learning, decision-making, and communication based on your unique cognitive style. From performance to parenting, he shows how your “brain type” influences every part of life and how to hack it for focus, clarity, and flow. This episode is packed with high-impact strategies for biohacking your brain, improving human performance, upgrading memory, and building real resilience using smarter not harder protocols. You'll Learn: • What Jim Kwik takes daily for brain speed, cognition, and mental stamina • The exact nootropics Dave Asprey uses (and the ones he avoids) • How sleep apnea nearly destroyed Jim's performance and how he hacked it • The connection between mitochondria, memory, and metabolism • Why brain inflammation blocks focus and cognitive clarity • When to use cold therapy, hyperbaric oxygen, and stem cells for brain repair • How to know if your brain needs more acetylcholine and what happens if you overdo it • The best biohacking tools for focus, speed reading, learning, and flow state • Why your brain animal determines how you learn, lead, and connect Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keyword Index: Acetylcholine supplements, Alpha GPC vs CDP choline, Post-traumatic growth brain, Stem cells for brain repair, Hyperbaric oxygen therapy for TBI, Brain inflammation supplements, Learning disabilities recovery, Best supplements for neurogenesis, Brain fog biohacks, Brainwave training programs, Smart drug protocols, Cognitive stack routines, Mitochondrial support for cognition, Electrolytes for brain performance, Danger Coffee brain benefits, ADHD nootropics protocol, Sleep apnea and cognition, High dopamine supplements, Brain types and learning styles, Upgrade Labs review Thank you to our sponsors! Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body's really doing behind the surface. GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what's in your air. BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino. Resources: • Jim's Website: https://www.jimkwik.com/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 — Introduction & Brain Health • 0:47 — Childhood Injury & Struggles • 2:53 — Adversity & Purpose • 6:31 — Nootropics & Optimization • 18:49 — Daily Biohacking Habits • 32:14 — Exercise & Brain Function • 34:21 — Learning & Cognition • 38:06 — Sleep & Resilience • 41:41 — Brain Types Explained • 52:16 — Parenting & Neuroplasticity • 57:19 — Limitless Update & Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the most powerful upgrades for brain energy, metabolism, and drive aren't in mainstream medicine, but in rare peptides and misunderstood hormones? In this episode, you'll discover the cutting-edge compounds, nootropics, and hormonal strategies that elite biohackers are using right now to optimize every part of their biology. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Jay Campbell and Hunter Williams, co-founders of BioLongevity Labs—a performance biotech company creating oral peptide-based products like BioMind and BioGutPro. Jay is a globally recognized expert in testosterone optimization, author of The TOT Bible, and a leading voice in hormone and peptide therapeutics. Hunter is a high-performance coach and podcast host focused on metabolism, mindset, and men's health through functional medicine and advanced supplementation. In this high-energy, high-clarity conversation, the trio explore what's working right now in advanced human performance, spanning hormone synergy, mitochondrial enhancement, libido compounds, nootropics, and muscle-preserving stacks. You'll hear why Dave injects estradiol three times per week, how Jay and Hunter use oral bioregulators to improve gut-brain signaling, and what peptides are quietly reshaping the future of health. You'll Learn: • Who should use estradiol—and how it can protect brain performance in men • The real role of testosterone and estradiol synergy in male health and longevity • How BioLongevity Labs is innovating with oral peptide delivery for cognitive and gut health • Why peptides like BPC‑157, TB‑500, PT‑141, and SS‑31 are changing mitochondrial care • The truth about Melanotan‑1, SLU, AOD‑9604, GW‑501516, and BAM‑15 • What makes BioMind and BioGutPro different from standard nootropic or probiotic stacks • Why libido and metabolic health are deeply connected • The dangers of unvetted peptide sources—and what to look for in quality and bioavailability This is essential listening for anyone serious about biohacking, hormone optimization, mitochondrial support, brain energy, nootropics, neuroplasticity, functional medicine, sleep optimization, metabolism, and smarter-not-harder living. Keyword Index: estradiol for men, Dave Asprey hormone therapy, Jay Campbell BioLongevity Labs, Hunter Williams performance coaching, BPC‑157 recovery peptide, TB‑500 tissue regeneration, PT‑141 libido peptide, SS‑31 mitochondria peptide, Melanotan‑1 for skin and mitochondria, SLU stack, AOD‑9604 fat loss peptide, GW‑501516 Cardarine, BAM‑15 mitochondrial uncoupler, oral peptide delivery, BioMind brain supplement, BioGutPro gut-brain axis, testosterone estradiol synergy, mitochondrial uncoupling, nootropic peptide stacks, performance biohacking supplements Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! Puori | Head to http://puori.com/dave for 20% off, including subscriptions. Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • BioLongevity Labs Website: https://biolongevitylabs.com/?ref=DAVE# • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 – Trailer 01:00 – Introduction & Early Days of Biohacking 02:03 – Peptides 101: Foundations and Frameworks 03:06 – Peptides for Healing, Cognition, and Longevity 07:56 – Bioregulators and Russian Innovations 11:07 – Side Effects and Safety of Peptides 22:27 – Oral Peptides and Product Innovations 27:41 – Body Composition, Hormones, and Fat Loss 32:02 – Testosterone, Estrogen, and Male Health Protocols 45:03 – Peptides for Performance, Fat Loss, and Longevity 1:26:32 – Loose Skin, Surgery, and Body Transformation 1:38:00 – Closing Thoughts & Product Recommendations See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ready to learn about the secret compounds, molecules, nootropics, and stacks that Big Pharma doesn't want you to know about? This episode is packed with the exact dopamine-boosting compounds, stacks, and biohacking protocols that top performers are using to supercharge human performance, brain optimization, and long-term resilience. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Lucas Aoun, Australia's leading biohacker and founder of Ergogenic Health. Known for his fearless, data-driven experimentation, Lucas specializes in nootropics, dopamine modulation, mitochondria, and functional medicine. He's spent over a decade testing underground compounds, natural molecules, and hormone-based strategies to achieve elite-level brain and body performance. Together, they explore Russian-developed enhancers like Bromantane and ITPP, and reveal how these rare compounds impact dopamine regulation, neuroplasticity, and mental drive. You'll learn how to upregulate tyrosine hydroxylase (your brain's dopamine switch), build targeted stacks for motivation and confidence, and avoid the common supplements that quietly kill your ambition. They also dive into the connection between dopamine and testosterone, explaining how to rewire hormonal feedback loops to reclaim masculinity, energy, and purpose. From libido hacks and prolactin suppression to stacking dopamine with GABA and acetylcholine, this episode gives you a complete system for motivation mastery. Other key topics include the dangers of chronic ashwagandha use, sleep optimization for dopamine recovery, the truth about adaptogens and cold therapy, ketosis, fasting, DHT science, ciproheptadine microdosing, and why mitochondrial support is essential for long-term performance and metabolism. You'll Learn: • The #1 Russian compound for explosive dopamine and drive • Why most “calming” supplements destroy your ambition • How dopamine and DHT shape masculinity and performance • Advanced biohacks for sleep, motivation, libido, and mood • The truth about serotonin dominance and how to escape it • Which functional medicine tools enhance brain energy and metabolism • How to build your own dopamine protocol using proven nootropics • Why mitochondrial health is the hidden key to motivation and mood This is essential listening for anyone serious about biohacking, brain optimization, hormone hacking, nootropics, functional medicine, emotional resilience, and building a state of unstoppable energy. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE. Resources: • Lucas's Website: https://www.boostyourbiology.com/ • Lucas's YouTube: https://www.youtube.com/c/boostyourbiology • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Tags: dopamine boosters, russian nootropics, bromantane benefits, biohacking dopamine, boost motivation naturally, dopamine stack, lucas aoun podcast, dave asprey dopamine, nootropics for energy, secret russian compounds, brain optimization, biohacking supplements, increase dopamine levels, functional medicine hacks, hormone optimization, dopamine and testosterone, neuroplasticity hacks, superhuman energy, underground nootropics, dopamine protocols See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ep. 196:  Welcome back to POW. Today we have an amazing episode all about non-toxic living. You'll hear from top experts sharing practical advice on addressing mold exposure, microplastics, and hidden household dangers that can affect your health. Having this podcast and speaking to incredible experts like Allison Evans, Mike Feldstein, and Dave Asprey has truly helped me embrace non-toxic living in a balanced way. Whether you're curious about improving air quality, balancing hormones naturally, or seeking clearer skin, this episode is packed with insights to help you create a healthier sanctuary at home. Tune in for inspiration and actionable tips to enhance your non-toxic journey! Leave Me a Message - click here! For Mari's Instagram click here! For Pursuit of Wellness Podcast's Instagram click here! For Mari's Newsletter click here! For Allison's Instagram click here! For Mike's Instagram click here! For Dave's Instagram click here! Sponsored By: Upgrade your kitchen with Caraway's non-toxic cookware. Visit http://carawayhome.com/WELLNESS10 or use code WELLNESS10 for 10% off your next purchase. Get better sleep, hair and skin with Blissy and use POWPOD to get an additional 30% off at http://blissy.com/POWPOD The first 1,000 to join at http://functionhealth.com/POW or use gift code POW at sign-up get a $100 credit toward their membership. Maui Nui delivers wild-harvested, nutrient-rich venison straight to your door. Order now at http://mauinuivenison.com/POW. Supply is limited so don't wait! Breathe easier with Jaspr, the commercial-grade air scrubber that's quiet, powerful, and sleek. Get $400 off with code POW at http://jaspr.co/pow. Show Links: Support your gut, skin & immunity with Colostrum & Collagen Peptides, a 3-in-1 formula featuring probiotics and grass-fed collagen. Topics Discussed 00:08 - Introduction 02:20 Understanding preservatives in baby products (Ep. 110: Allison Evans) 04:03 What's in Branch Basics & how to use it 06:50 Pregnancy, mold exposure & candida 10:32 Coffee enemas 12:40 Clean eating 17:24 Clean living for kids: eczema, epigenetics & detox tools 21:07 Where to start with Branch Basics & removing hidden toxins 22:37 Getting sick from toxic air: respiratory & autoimmune flare-ups (Ep. 145 Mike Feldstein) 23:39 Mold exposure & mycotoxin testing 25:35 Air awareness: indoor & outdoor pollution 28:30 Ventilation tips & how cooking pollutes indoor air 34:35 Pets as a source of indoor toxins 38:15 How bad air quality affects people differently 40:32 The rise of mold awareness 47:48 Early mold exposure, food mycotoxins & the mold–Lyme connection (Ep. 100: Dave Asprey) 51:30 Coffee mold toxins & how to find mold-free beans 56:26 How mold exposure disrupts hormones & weight 59:30 Animal protein & why quality matters Learn more about your ad choices. Visit megaphone.fm/adchoices

Getting 50 grams of protein per meal may be the single most underrated biohacking protein strategy for muscle growth, metabolism, and longevity. In this episode, you'll discover why animal protein vs vegan is not a fair match biologically, how hitting the leucine threshold activates mTOR for longevity, and why muscle is the most overlooked organ of aging. This is must-listen content for anyone optimizing human performance, hacking metabolism, or reversing muscle loss with food. Host Dave Asprey is joined by Dr. Gabrielle Lyon, a pioneer in Muscle-Centric Medicine®, functional medicine expert, and top authority on clinical nutrition for longevity. Trained by protein researcher Dr. Donald Layman, she brings decades of expertise on how to use high-protein diets, amino acid science, and functional medicine to radically improve healthspan and brain optimization. Dr. Lyon works with everyone from special operators to aging patients, making her one of the most trusted voices in anti-aging diet strategies. Watch this channel on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll learn: • Why 50g of protein per meal matters more than total daily intake • How mTOR and longevity are misunderstood in mainstream nutrition • Why protein vs plant protein debates ignore hard biological data • How leucine thresholds determine muscle activation • Why fasting and protein cycling beats low-protein veganism • How ketosis and protein intake impact metabolic health • Why many on a vegan diet experience sleep issues, hormone crashes, and reduced resilience • How functional medicine podcasts like this one reveal the truth about aging and muscle loss • What happens clinically when patients switch to a high-protein diet • How to use supplements, nootropics, and protein hacks to enhance neuroplasticity, mitochondrial energy, and total body performance If you've ever asked “what's the best protein for muscle growth?” or “how does protein affect metabolism in aging?”, this episode gives you evidence-based answers from the front lines of clinical nutrition. This channel is a must-listen for anyone serious about hacking their biology, upgrading cognitive performance, and using unconventional tools to create lasting transformation. Whether you're tracking HRV, optimizing for deep sleep, or working toward metabolic resilience, these conversations deliver insights you won't hear anywhere else. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! 40 Years of Zen | Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Lumiram | Go to http://healthlighting.com/dave to save 10% on your order. Resources: • Gabrielle's Website: https://drgabriellelyon.com/ • Gabrielle's IG: https://www.instagram.com/drgabriellelyon/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 Trailer • 0:51 Protein Controversy • 2:38 Leucine • 6:00 mTOR, Methionine, and Protein Synthesis • 9:00 Vegan vs. Carnivore • 16:00 Optimizing Protein Intake & Aging • 22:00 Carbohydrates, Hormones, and Female Health • 28:00 Environmental Impact & Food Sourcing • 34:00 Debunking Plant-Based Documentaries • 40:00 Key Takeaways & Closing Keywords: protein vs plant protein, 50 grams of protein, biohacking protein, mTOR and longevity, animal protein vs vegan, leucine threshold, Gabrielle Lyon, muscle-centric medicine, best protein for muscle growth, anti-aging diet, muscle as organ of longevity, fasting and protein, ketosis and protein, vegan diet risks, optimizing metabolism, high-protein diet, functional medicine podcast, Dave Asprey protein, aging and muscle loss, clinical nutrition for longevity See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode reveals how military-grade sound frequencies can rapidly shift your mental state, enhance neuroplasticity, and accelerate brain optimization. You'll learn how to hack your nervous system using real-time biometric data, how frequency compositions are changing functional medicine, and why sound is emerging as one of the most powerful tools for human performance and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Rev. Michael Beckwith, founder of the internationally renowned Agape International Spiritual Center and one of the most respected voices in spiritual transformation and human potential. With over four decades of teaching, Michael has impacted millions through his work in consciousness, meditation, and high-performance inner development. Joining him is Henry Penix, founder of SOAAK Technologies, a cutting-edge frequency healing platform trusted by clinicians, elite performers, and even the US Air Force. Together, they explore how sound can rewire brainwaves, reduce anxiety, support sleep optimization, and create measurable changes in metabolism, mood, and mindset. You'll learn: • How the Air Force is using frequency tech to support mental recovery and cognitive performance • What makes SOAAK's custom sound compositions biologically effective • How sound impacts mitochondria, mood, and brainwave coherence • The link between sound healing, neuroplasticity, and high-performance states • Why hydration, supplements, and biohacking stacks boost sound-based protocols • The surprising connection between prayer, frequency, and emotional regulation • How to integrate sound biohacks with fasting, ketosis, sleep tools, and nootropics • Why this tech pairs with cold therapy, Danger Coffee, and smarter not harder principles This channel is a must-listen for anyone serious about hacking their biology, upgrading cognitive performance, and using unconventional tools to create lasting transformation. Whether you're tracking HRV, optimizing for deep sleep, or working toward metabolic resilience, these conversations deliver insights you won't hear anywhere else. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order Resources: • SOAAK Website: https://www.soaak.com/dave • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 — Trailer • 1:00 — Intro • 2:42 — Humor & Frequency • 5:20 — Soak App Origins • 8:15 — Biometrics & Sound Delivery • 10:40 — Inner Alignment & Brain Mapping • 13:46 — Beckwith's Results • 19:44 — Sound & Biohacking • 23:32 — Mood & Sleep Shifts • 24:53 — Supplements & Water Synergy • 26:25 — Emotional Congruence • 29:49 — Frequency & Sexuality • 32:43 — Military & Medicine • 35:32 — Light, Sound & Quantum Effects • 40:34 — Analog vs. Digital Sound • 48:45 — Spiritual Experiences • 53:14 — Conclusion & CTA See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You've been lied to about how long it takes to change a habit. This episode reveals a powerful, science-backed method to rewire your brain in just 63 seconds—without relying on willpower. You'll discover how to use the 63-second window to interrupt destructive thought loops and how true habit change requires 63-day habit formation, not the popularized 21-day myth. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Caroline Leaf, a cognitive neuroscientist and best-selling author known for her groundbreaking work on the mind-brain connection. With over four decades of experience, Dr. Leaf has helped millions better understand the differences between the mind vs brain, how to harness intuition and neurobiology, and how to apply science-based tools for healing trauma with neuroscience. Her newest work, Help in a Hurry, builds on her bestselling book Cleaning Up Your Mental Mess, offering real-time tools to regain mental control during moments of emotional chaos. You'll learn: • Why the 21-day habit myth persists and what the neuroscience actually shows • How to use the 63-second window to stop toxic thoughts from wiring into your brain • What happens during the 63-day habit formation cycle and how to stay on track • The difference between the subconscious vs unconscious mind • How to rewire your brain for better emotional regulation and decision-making • The power of forgiveness and how it relates to quantum entanglement • Caroline Leaf's mental mess strategies to overcome triggers in real time • Why the free will neuroscience debate matters for your mental sovereignty • How to interpret intuitive “blips” through a neuroscience lens • Tools for using neuroplasticity to heal trauma, manage emotions, and boost clarity This episode is a must-listen for anyone interested in brain optimization, biohacking, human performance, mental resilience, and smarter-not-harder strategies for personal growth. Whether you're focused on fasting, cold therapy, nootropics, sleep optimization, or upgrading your mitochondria, these mental frameworks will amplify your results. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order IGNITON | Save 10% at https://endlss.io/sl/igniton/daveasprey Resources: • Order Caroline's New Book ‘Help in a Hurry' - https://a.co/d/6O9RaJB • Caroline's Website: https://drleaf.com/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 Trailer • 0:54 Intro • 1:12 63-Second Habit Rule • 5:14 21 vs 63 Days • 9:20 Habits vs Trauma • 14:19 Healing & Spiritual Insight • 17:43 Free Will & Mind-Brain Link • 19:11 Conscious vs Subconscious • 26:02 Intuition & Memory • 33:15 AI & Consciousness • 37:56 Death & Energy • 51:21 Forgiveness & Entanglement • 55:14 Self-Regulation Tools See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ep 59: Healing, Sobriety, Stem Cells & SAVERS: My Top Takeaways from the Biohacking ConferenceDescription: Ever left an event feeling so lit up that you wanted to shout it from the rooftops? That's this week's show.In this solo episode, I'm taking you inside one of the most jam-packed wellness and biohacking events I've ever attended. You'll hear personal insights from Dave Asprey's Beyond Conference (formerly named Biohacking Conference), including a healing moment I wasn't expecting, and the “this changes everything” takeaways that rocked me to my core.We're talking brain health, emotional regulation, detoxification, quantum healing, conscious capitalism, and yes—a doctor who pulled a laser out of his pocket and aimed it at my head (and something in my elbow shifted).Some featured voices include:[5:00] Dr. Joe Dispenza, on reprogramming the subconscious and the healing power of the mind[7:00] James Nestor, author of Breath, on the science (and urgency) of how we breathe[9:50] Christian Drapeau, from StemRegen, on the use of stem cells in the treatment of long-term degenerative disease [11:55] Hal Elrod, founder of the Miracle Morning, and his SAVERS practice [15:05] Vani Hari, aka The Food Babe, on the battle to keep toxins off your plate[20:37] Jirka Rysavy, Gaia's elusive founder, on next-level energy healing and personal power[22:42] Dr. Jerry Tennant, author of Healing Is Voltage, on frequencies, trauma, and cellular healing[28:35] Daymond John, who opened up about addiction, entrepreneurship, and reclaiming healthYou don't need to be perfect. Just present. Whether that means skipping the soda, booking the sauna, or tossing those sketchy snack bars, the next right step is always enough. Biohacking isn't about trends and hacks; it's about learning to support your body and mind so you can actually live your life.RATE & REVIEWLoved this episode? Drop a review and share it with someone who's ready to feel better from the inside out.

Cozy Earth: Go to https://cozyearth.com and use code ICH for 40% off the softest bedding, bath and apparel! Pipedrive: Try it free for 30 days at https://pipedrive.com/iced Range Rover Sport: Start designing your Range Rover Sport today at https://www.rangerover.com/us/sport Shopify: Sign up for a $1 per month trial period at https://shopify.com/ich MagicMind: Get 60% off the Magic Mind offer here: https://magicmind.com/ich #magicmind #mentalwealth #mentalperformancecoach Follow Dave Asprey: On Youtube - https://www.youtube.com/c/daveaspreybpr On Instagram - https://www.instagram.com/dave.asprey/ On X - https://x.com/bulletproofexec Website - https://daveasprey.com/ Apply for The Index Membership: https://entertheindex.com/ Add us on Instagram: https://www.instagram.com/jlsselby https://www.instagram.com/gpstephan Official Clips Channel: https://www.youtube.com/channel/UCeBQ24VfikOriqSdKtomh0w For sponsorships or business inquiries reach out to: tmatsradio@gmail.com For Podcast Inquiries, please DM @icedcoffeehour on Instagram! Timestamps: 00:00:00 - Intro 00:01:30 - Departure from Bulletproof 00:04:13 - 4 types of “qualified” people 00:06:25 - Screening execs psychologically 00:12:02 - Firing People 00:14:04 - Ideal interview questions 00:16:28 - Sponsor - Cozy Earth 00:21:37 - What is “Type 1 or 2” 00:26:36 - Can mental training fix most issues? 00:32:51 - Medicine that reduce reaction time 00:35:31 - Are you happier than most people? 00:36:12 - How long can you live? 00:37:15 - Sponsor - Pipedrive 00:38:54 - Healthier at 180 than now 00:41:12 - How much have you spent on your body? 00:44:08 - Forgetfulness cured 00:50:33 - His early 20s 00:51:24 - Overcoming Asperger's 00:53:20 - Smart kids with Asperger's 00:54:49 - Making $6M and losing it by 26 00:57:47 - Beginning of your healing journey 01:00:26 - Limitless vs. Modafinil 01:05:19 - Craziest biohack you've tried 01:06:34 - Sponsor - Range Rover 01:07:32 - Sponsor - Shopify 01:09:01 - Stem cell treatments 01:12:24 - Most overprescribed medicine 01:13:17 - Rate these biohacks 01:18:47 - Practical biohack tips 01:22:00 - How to get perfect sleep 01:28:49 - Worst foods most people eat 01:29:59 - Best everyday food 01:33:30 - Dangerous biohacking experiences 01:34:18 - Anti-aging products 01:37:43 - Is tap water safe? 01:39:59 - Thoughts on Bryan Johnson 01:40:41 - Eating while traveling 01:41:28 - How bad is alcohol? 01:45:13 - Fried food and brain health 01:47:29 - Nicotine 01:51:13 - Adderall 01:59:11 - Dopamine detox 02:01:51 - Freezing yourself post mortem 02:05:37 - A question you wish people asked 02:07:11 - Why are you controversial? 02:10:43 - Best health tip to apply now *Some of the links and other products that appear on this video are from companies which Graham Stephan will earn an affiliate commission or referral bonus. Graham Stephan is part of an affiliate network and receives compensation for sending traffic to partner sites. The content in this video is accurate as of the posting date. Some of the offers mentioned may no longer be available. Learn more about your ad choices. Visit podcastchoices.com/adchoices

What is Herbal Ecstasy—and why does it matter? This might be one of the most insane episodes we've ever recorded, and we had to bring it back because the story is too wild, too relevant, and too packed with real lessons in biohacking, brain optimization, and supplement hacking to miss. Host Dave Asprey sits down with Shaahin Cheyene, the renegade teenage entrepreneur who built a billion-dollar supplement empire before he could legally drink. As the creator of Herbal Ecstasy, Shaahin hacked natural compounds into high-performance nootropics that boosted energy, neuroplasticity, and metabolism—long before biohacking was a movement. He faced seven federal investigations, never spent a day in jail, and went on to pioneer the vaporizer industry and dominate Amazon with advanced supplement marketing. This episode explores how Shaahin reverse-engineered functional medicine principles, used ancient plant medicine to upgrade human performance, and scaled a controversial brand using raw hustle and hacking tactics. You'll hear how Herbal Ecstasy worked, why it was banned, and what it teaches us about supplements, mitochondrial function, dopamine regulation, and the dark politics behind wellness innovation. You'll learn: • Why Herbal Ecstasy became a billion-dollar underground supplement • How Shaahin used nootropics and adaptogens to hack energy, focus, and neuroplasticity • What his clash with the FDA reveals about supplement regulation and functional medicine • How dopamine, mitochondria, and metabolism drive human performance • The difference between hacking systems vs conforming to broken ones • How storytelling, podcasting, and controversial supplements build legacy brands Whether you're optimizing your sleep, hacking your brain, experimenting with ketosis or fasting, or upgrading your stack with supplements that actually work—this channel delivers strategies, cautionary tales, and insight you won't find anywhere else. lt is essential listening for anyone serious about biohacking, brain optimization, supplements, mitochondria, metabolism, functional medicine, nootropics, longevity, dopamine, cold therapy, sleep optimization, emotional regulation, neuroplasticity, fasting, podcasting, RFK-era health freedom, ketosis, entrepreneurship, and building influence smarter not harder—with or without Danger Coffee. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! Resources: • Shaahin's Website: https://www.shaahincheyenne.com/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 — Trailer • 0:45 — Intro and guest setup • 4:39 — Escaping Iran and early hustle • 8:26 — Birth of Herbal Ecstasy • 14:21 — Explosive growth and legal heat • 25:06 — Lessons on money and business • 31:17 — Inventing the digital vaporizer • 40:03 — Hacking success on Amazon • 41:59 — Nootropics and the Limitless pill • 46:38 — Martial arts and mental resilience • 55:44 — Podcasting, media, and influence • 1:07:09 — Where to find Shaahin and closing thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You're leaving brainpower on the table, and this episode shows you how to reclaim it. Learn how to boost cognitive performance by 25% without relying on pills, stimulants, or gimmicks. Host Dave Asprey sits down with global finance expert and cross-cultural thinker Richard Conrad to explore how your cultural programming shapes your biology, metabolism, neuroplasticity, and even your ability to reach peak human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Richard is the author of Culture Hacks and has spent over 30 years living and working across Japan, China, and the U.S. He's a master of decoding hidden mental frameworks that influence perception, longevity, and decision-making. This is a must-listen if you care about brain optimization, functional medicine, and living smarter, not harder. Together, they break down why different cultures process truth, time, and identity so differently and how these filters influence your beliefs about supplements, fasting, cold therapy, sleep optimization, and more. You'll also learn why Americans are biologically wired for linear logic, how agrarian versus warrior cultures shaped meditation and nervous system regulation, and how to train your mitochondria to perform like a samurai's. You'll Learn: • Why your culture shapes how your brain processes reality • How to shift from linear to systems thinking for better neuroplasticity • The connection between meditation styles, nervous system wiring, and mitochondria • How to apply ancient frameworks to modern biohacking and human performance • Why longevity without financial planning is a broken strategy • How to avoid cognitive bias by decoding relative versus absolute truth This channel is packed with biohacking wisdom, from nootropics and ketosis to Danger Coffee, financial resilience, and how your beliefs about aging could be accelerating it. Whether you're focused on hacking your brain, upgrading your metabolism, or extending your longevity, this is one of the most unique mind-expanding channels around. It is essential listening for anyone passionate about biohacking longevity, functional aging, mitochondrial testing, and next-gen human optimization. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. Generation Lab | Go to https://generationlab.com/, use code DAVE20 for $20 off, and see what your body's really doing behind the surface. Resources: • Order Richard's Book “Culture Hacks”: https://a.co/d/9122Q25 • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:10 Intro • 03:15 Middle East Perception Gap • 06:53 China's Strategy & Trade • 09:53 Japan vs China Mindsets • 14:28 Logic: East vs West • 18:23 Cultural Tools for Life • 24:23 Global Population Crash • 30:18 Shifting Economic Power • 55:33 Smart Finance Principles • 01:09:28 Real Estate & Policy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This may be the most cutting-edge life extension technology you'll hear about for decades. You'll discover how mitochondrial transfusion, rejuvenation, and repair could reverse biological aging, supercharge your metabolism, and radically extend healthspan—all by upgrading the cellular energy systems that power every function in your body. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with inventor and tech entrepreneur Tom Benson, founder of Mitrix. After launching three successful Silicon Valley companies, Benson shifted focus to one of the most promising frontiers in science: mitochondrial bioreactors designed to regrow your own autologous mitochondria. This isn't theory—it's a near-future anti-aging technology poised to transform functional medicine, personalized medicine, and the global conversation around aging reversal. They explore how mitochondrial DNA mismatches affect aging, why mitochondria act like cellular AI cores, and how dysfunction in these ancient organelles contributes to neurodegenerative disease, metabolic decline, and cognitive disorders. You'll learn how restoring mitochondria could enhance everything from stem cell therapy and nootropics to ketosis, fasting, cold therapy, and even sleep optimization. You'll Learn: • Why mitochondria may be the real control centers of human biology • How mitochondrial transfusion could revolutionize longevity and functional medicine • The connection between mitochondrial dysfunction and Parkinson's, autism, and ALS • Why brain optimization and neuroplasticity depend on cellular energy • How stem cell-derived mitochondria compare to nootropics and NAD • What happens when mitochondrial DNA and nuclear DNA are mismatched • Why early aging might start with your egg cells' mitochondrial computing • How mitochondrial health influences metabolism, ketosis, and fat storage • Why stress, toxins, and pharmaceuticals like statins wreck mitochondrial function • What it takes to scale mitochondrial bioreactors for widespread human use • How mitochondrial hacking could improve immune function, sleep, and resilience • Why the future of biohacking might begin with testing and upgrading your mitochondria This episode is essential listening for anyone passionate about biohacking longevity, functional aging, mitochondrial testing, and next-gen human optimization. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Thank you to our sponsors! -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order. Resources: • Mitrix Website: https://www.mitrix.bio/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:42 Intro • 04:33 Mitochondrial DNA & Performance • 08:49 Challenges in Mitochondrial Therapy • 13:31 Future Applications • 19:07 Mitochondria & Longevity • 20:19 Traditional Medicine • 28:50 Space Exploration • 29:35 Human Fragility • 30:19 Aging Revisited • 32:52 Experimental Research • 36:04 Ethics & Risks • 41:24 Mental Health Links • 46:28 Treatment Breakthroughs • 51:01 Personal Longevity Hacks • 54:30 Wrap-Up & Contact See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Ep. 58 | My Top Takeaways from the Ultimate Wellness EventSummer might be heating up, but my notebook from the Beyond Conference is still smoking hot. In this episode, I'm sharing my top vendor highlights from what was formerly known as the Dave Asprey Biohacking Conference, now rebranded as the Beyond Conference (and honestly, the name glow-up fits).From lymphatic compression suits and PEMF chairs to frequency-embedded clothing and red light facelifts (yes, really), this was a wellness wonderland of cutting-edge healing tools. If you've been wondering what's worth it in the ever-expanding biohacking world, this episode will save you from shiny object overload.In this episode, you'll learn:[2:40] Why “biohacking” is evolving and what's replacing it[10:40] My personal favorites for detox support, brain health, sleep, and energy[12:37] How I use BrainTap for recovery and stress[13:00] The frequency-based clothing line that's changed how I feel day-to-day[15:45] A hydrogen bathtub that's now on my wishlist[17:10] And yes… the red light device that gave me an impromptu facelift on the show floor

What if one spray could upgrade your brain, protect your mitochondria, and outperform IV therapy and liposomal supplements? In this episode, you'll discover the breakthrough science behind topical glutathione delivery that uses your skin's water channels to raise intracellular glutathione levels in just 60 seconds. Learn how this powerful antioxidant works at the cellular level to reduce oxidative stress, support mitochondrial function, and drive real improvements in brain health, emotional resilience, and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Nayan Patel, a world-leading pharmacist and formulator who pioneered this next-gen delivery method. With over two decades of clinical work in functional medicine, Nayan has helped reshape how we think about glutathione benefits, systemic detox, and performance optimization. His research shows that topical delivery bypasses traditional fat-based absorption, achieving higher brain uptake and faster results than IVs or capsules. You'll learn: • Why glutathione for longevity is foundational to biohacking • How it protects against cellular inflammation and improves TBI recovery issues • Why pairing glutathione with NAD+, vitamin C, or pharmaceutical nicotine creates a powerful synergy • How it preserves NAD+, supports sirtuins, and enhances ATP production • When to use glutathione as an immune booster for resilience and recovery This conversation also reveals the truth behind liposomal supplements, how your age affects glutathione absorption, and why this molecule is critical for anyone using nootropics, in ketosis, or pushing metabolic limits. This episode is essential listening for anyone into biohacking, cold therapy, functional medicine, or RFK-style medical freedom. You'll walk away with practical tools to boost nitric oxide naturally, prevent dysfunction, and optimize your biology whether you're on a carnivore diet or just looking for an edge. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Resources: • Auro Wellness Website: Use code ‘dave10' at checkout https://aurowellness.com/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 00:20 Intro • 01:12 Water Channel Delivery Explained • 02:25 What Makes Glutathione Special • 05:04 Why IVs and Liposomes Fail • 06:29 Measuring Glutathione in the Brain • 10:42 Key Benefits and Use Cases • 20:49 Emotional Resilience Effects • 23:54 Sensitivity and Response • 24:55 Best Timing for Use • 25:53 Workout Performance Boost • 26:47 Brain Health and TBI Support • 28:22 Best Stack Combinations • 29:32 Nicotine + Glutathione Synergy • 33:18 Longevity, Sirtuins, and Genes • 40:36 Glutathione as Immune Booster • 43:15 Peptides and Next-Gen Hacks • 45:29 Dosing Tips and Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If you care about longevity, brain optimization, sexual performance, or metabolism, this molecule changes everything. Host Dave Asprey sits down with nitric oxide pioneer Dr. Nathan Bryan to reveal why this overlooked molecule controls your blood flow, mitochondrial energy, neuroplasticity, insulin response, and even your libido. You'll learn how nitric oxide acts as a master switch for human performance and why the medical system has ignored it for decades. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dr. Nathan Bryan is a world-renowned expert in nitric oxide biochemistry with over 20 years of clinical research, multiple patents, and collaborations with Nobel Prize-winning scientists. His groundbreaking work forms the foundation for modern functional medicine protocols targeting blood flow, metabolism, cognitive enhancement, and mitochondrial upgrades. You'll learn: • How nitric oxide drives mitochondria, metabolism, and human performance • Why most nitric oxide supplements fail and how to spot real ones • The critical role nitric oxide plays in brain optimization, libido, and insulin signaling • How poor oral health, statins, and PPIs can kill nitric oxide production • What nitric oxide has to do with sleep optimization, aging, and disease prevention • How to stack nitric oxide with fasting, ketosis, nootropics, red light, and supplements • Why “Smarter Not Harder” starts with nitric oxide fueled upgrades This episode is essential listening for anyone into biohacking, cold therapy, functional medicine, or RFK-style medical freedom. You'll walk away with practical tools to boost nitric oxide naturally, prevent dysfunction, and optimize your biology whether you're on a carnivore diet or just looking for an edge. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Get Nitric Oxide products for 10% off with code ‘Dave': https://bit.ly/Nitric-Oxide-Product SPONSORS: Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Resources: • Nathan's Website: https://www.n1o1.com • Nathan's YouTube: https://www.youtube.com/channel/UCtftGy8e0r9DO8ActcyGi4w • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:03 Intro • 01:15 Why Medicine Ignores Nitric Oxide • 01:59 What Nitric Oxide Does in the Body • 04:46 How the Body Makes Nitric Oxide • 07:12 Diet's Impact on NO Levels • 13:28 Why Most NO Supplements Fail • 19:32 Personalized Biohacking with NO • 22:33 How Medicine Misses the Mark • 30:40 Oral Health and Nitric Oxide • 31:30 Mouthwash Kills Your Microbiome • 32:28 The Problem with Fluoride • 33:25 Better Toothpaste for NO • 33:49 NO's Role in Energy and Healing • 34:17 Blood Pressure and NO • 35:29 NO and Sexual Performance • 37:09 NO and COVID Recovery • 40:50 Brain Fog and NO Deficiency • 49:01 Carnivore, Sugar, and NO • 50:11 Why You Still Need NO Supplements • 54:19 Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if you could reverse your biological age, boost your brainpower, and sleep like a baby—using just cold showers, glucose monitors, and a ring on your finger? In this wildly entertaining and thought-provoking episode, we dive headfirst into the world of biohacking—the movement that's turning health into a high-tech DIY experiment. Is it a real revolution in wellness, or just the latest Silicon Valley wellness flex? Here's what you'll discover in this episode: Why tech entrepreneurs are spending millions a year to age backward The wild experiments of Bryan Johnson, including metrics you never thought needed tracking What “optimizing your mitochondria” actually means (and why people are obsessed with it) The philosophical side of biohacking: is it personal empowerment—or just data addiction? Why tracking your sleep might actually be ruining it The uncomfortable truth about who can afford to biohack Are wearables helping you tune in—or tuning you out of your own body? We'll also explore how biohacking is reshaping digital wellness, the risks of going too far, and what this movement says about the future of personal health in a tech-driven world. Whether you're a die-hard health hacker or just wondering if buttered coffee is worth the hype, this episode breaks it all down with insight, humor, and a healthy dose of skepticism. Is biohacking the key to a better life—or just a better-looking Instagram post? Tune in to find out. This episode is brought to you by Shield Your Body—a global leader in EMF protection and digital wellness. Because real wellness means protecting your body, not just optimizing it. If you found this episode eye-opening, leave a review, share it with someone tech-curious, and don't forget to subscribe to Shield Your Body on YouTube for more insights on living healthier with technology.

Supercharge your mitochondria, slash inflammation, and boost energy with one of the most overlooked hacks in human performance. This episode reveals how just 15 minutes of oxygen-based exercise can radically improve metabolism, brain optimization, and even reverse chronic conditions, without expensive gear or endless protocols. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Brad Pitzele, founder of One Thousand Roads and creator of the LEO System, an affordable and science-backed way to do Exercise With Oxygen Therapy (EWOT) at home. After nearly dying from autoimmune illness and failed functional medicine treatments, Brad used this oxygen-based biohacking tool to fully reboot his health. His story and system offer breakthrough potential for anyone facing fatigue, inflammation, or looking to upgrade energy, resilience, and longevity. You'll learn: • How EWOT works differently from hyperbaric oxygen and why it's faster • Why brain fog, poor sleep, and chronic inflammation all trace back to oxygen supply • How oxygen hacking activates neuroplasticity, detox pathways, and energy production • When to stack with ketosis, red light, nootropics, and mitochondrial supplements • How elite athletes and chronically ill patients both use this protocol • Why “Smarter Not Harder” starts with oxygen-fueled mitochondrial upgrades This is essential listening for anyone serious about biohacking, functional medicine, brain optimization, metabolism, fasting, supplements, and longevity. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Get a free Ebook on EWOT to learn more today:https://cdn.shopify.com/s/files/1/0097/3186/6683/files/The_Oxygen_Advantage_Protocol_-_EWOT.pdf?v=1752173567 SPONSORS: Puori | Head to http://puori.com/dave for 20% off, including subscriptions. BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • One Thousand Roads Website: https://www.onethousandroads.com/• One Thousand Roads YouTube (more info on EWOT) : https://www.youtube.com/@OneThousandRoadsHQ • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Labs: https://upgradelabs.com • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:10 Introduction • 02:38 Discovering EWOT • 03:55 Autoimmune Breakdown • 06:54 Building One Thousand Roads • 15:00 EWOT Science & Benefits • 20:54 Protocols & Use Cases • 29:03 Real-World Results • 30:11 Brain Fog & Oxygen • 30:58 Athletic Performance • 31:41 Therapy Stacking • 34:44 Mitochondria & Aging • 37:08 Research & Studies • 40:00 Future of Oxygen Therapy • 43:02 Practical Tips & Access • 51:09 Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Wrinkles are just the surface. This episode reveals what's really happening beneath your skin and how to reverse it using stem cells, regenerative medicine, and the most advanced techniques in plastic surgery and aging. You'll learn how to improve facial skin tightening, reduce inflammation, and trigger deep skin rejuvenation with stem cells, red light therapy, and targeted procedures that actually work. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey shares his personal journey through weight loss and skin excess, including why he had 28 inches of skin removed and how he rebuilt facial structure using stem cells and longevity protocols. He's joined by Dr. Victor Urzola, a globally recognized expert in plastic surgery and aging, known for pioneering biohacking skin health techniques, cutting-edge facial reconstruction, and legalizing therapeutic stem cell use in Costa Rica. Together, they expose the hidden causes of wrinkles and aging, from mitochondrial slowdown to ligament laxity and collagen depletion. They also unpack the science behind breast implant health risks, silicone toxicity syndrome, and why thousands of women experience hormonal, neurological, and metabolic symptoms related to their implants. Dr. Urzola explains how explant surgery can improve hormone balance, sleep, HRV, metabolism, and even libido. You'll also hear how cosmetic procedures interact with HPA axis function and how skin and brain health are more connected than you think. This episode is a must for anyone serious about biohacking, skin optimization, stem cells and longevity, and functional medicine. Dave also breaks down his recovery stack, including exosomes, red light therapy, collagen cycling, nootropics, and how cosmetic procedures can be used to enhance—not just appearance—but total human performance. You'll learn: • The real root causes of wrinkles and sagging skin • How to use skin rejuvenation with stem cells for long-term results • Signs of silicone toxicity syndrome and what to do about it • Why cosmetic procedures impact hormone health and libido • The most effective strategies for facial skin tightening and recovery• How to approach breast implant health risks with functional medicine thinking Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: Generation Lab | Go to https://www.generationlab.com/ use code Dave20 for $20 off. Qualia | Go to https://www.qualialife.com/dave15 to get an additional 15% off subscriptions. fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Dr. Urzola's Website: https://drvictorurzola.com/en/ • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Labs: https://upgradelabs.com • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:39 Intro • 02:52 Breast Implants & Aesthetics • 03:40 Stem Cells in Cosmetic Procedures • 10:38 Skin Health & Anti-Aging Tips • 15:11 Red Light & Face Stimulation • 17:15 Platysma Muscle & Neck Aging • 21:01 Implant Risks & Reactions • 27:36 Vince & Longevity Science • 28:51 Implant Tolerance Explained • 29:52 Silicone Health Impact • 31:06 Inflammation & Genetics • 32:15 Explant Outcomes & Recovery • 40:14 Breastfeeding & Aesthetic Changes • 41:03 Lift vs. Implants • 45:39 Patient-First Medical Care • 53:32 Stem Cells & Medical Freedom • 56:21 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this season finale, Dr. Sherry McAllister takes a stroll down memory lane, recapping some of the most powerful, inspiring moments we've shared. From waking up our minds with Dr. Ellen Langer, to breathing with purpose thanks to Dr. Christiane Brems, and redefining nutrition with Udo Erasmus, this season was packed with insights for whole-being health. We explored how human connection can be a prescription for healing with Julia Hotz, got game-day ready with Dr. Karen Slota, and learned why quality sleep is essential for mental health from Dr. Barry Krakow. We tapped into biohacking with Dave Asprey, gained a fresh perspective on pain and healing with Dr. Stephen Hussey, and went behind the scenes with sports chiropractic legend Dr. Spencer Baron. Each episode brought fresh perspectives and practical tips to help you feel your best every day.Season 9 may be ending, but the momentum is just beginning. Dr. McAllister teases what's ahead in Season 10, including the Adjusted Reality book coming your way on October 14th!Ready to relive the highlights or catch up on what you missed? Tune in now and celebrate Season 9 with us.In the Adjusted Reality podcast, well-known athletes, celebrities, actors, chiropractors, influencers in the wellness industry, and other podcasters will talk with host Dr. Sherry McAllister, president, F4CP, about their experiences with health and wellness. As a special gift for listening today visit f4cp.org/health to get a copy of our mind, body, spirit eBook which focuses on many ways to optimize your health and the ones you love without the use of drugs or surgery. Follow Adjusted Reality on Instagram. Find A Doctor of Chiropractic Near You.Donate to Support the Chiropractic Profession Through Education.

Superintelligence is coming faster than anyone predicted. In this episode, you'll learn how to upgrade your biology, brain, and consciousness before AI and transhumanism reshape the future of health. Host Dave Asprey sits down with Soren Gordhamer, founder of Wisdom 2.0, to explore what superintelligence in 2027 means for your mind, body, and soul. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Soren has spent decades at the intersection of mindfulness, technology, and human development. He advises leaders at OpenAI, Google, and top wellness companies, and he leads global conversations around AI and consciousness. His work bridges ancient wisdom with biohacking, modern neuroscience, and the urgent need to stay human in a machine-dominated world. This episode gives you a tactical roadmap to build resilience before the world tilts. You'll gain practical tools for brain optimization, functional medicine, and biohacking strategies that sharpen cognitive health, reinforce emotional stability, and unlock peak human performance in a digital-first reality. From supplements and nootropics to neuroplasticity techniques, Dave and Soren show you how to protect your biology as AI accelerates beyond human speed. They break down how AI and human health intersect, explain why you need emotional strength to face the future, and offer guidance for raising kids in a world ruled by code. If you're preparing for 2027 superintelligence, navigating AI-driven parenting, or staying ahead of transhumanist health tech, this episode equips you for the coming wave. You'll Learn: • How AI is reshaping human connection, presence, and identity • Why emotional resilience and conscious awareness matter more than ever in an AI-driven world • How to raise connected, grounded children in a hyper-digital environment • What human flourishing looks like when technology outpaces biology • Why investing in presence, purpose, and inner development may be the ultimate upgrade • How leaders in wellness and tech are rethinking personal growth, governance, and ethics in 2027 • What it means to stay truly human—and fully alive—during the rise of superintelligence Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes drop every Tuesday and Thursday, where Dave asks the questions no one else dares and gives you real tools to become more resilient, aware, and high performing. SPONSORS: - LMNT | Free LMNT Sample Pack with any drink mix purchase by going to https://drinklmnt.com/DAVE. - ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Soren's New Book - The Essential: https://a.co/d/dALv7OS • Soren's Website: www.sorengordhamer.net • Soren's Instagram: https://www.instagram.com/wisdom2events/ • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Labs: https://upgradelabs.com • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

I am honored to reconnect with Dr. Tracy Gapin today. He is a board-certified urologist and men's health expert.  The current state of metabolic health in the United States and most Westernized countries has sparked a great interest in a GLP1 agonist, AKA Semaglutide Ozempic. I wanted to speak with a clinician who actively uses this medication. Dr. Gapin and I discuss what this drug class represents. (These are synthetic peptides.) We speak about Semaglutide, Ozempic, Wegovy, and oral Rybelsus. We get into current research, side effects, who should not take these medications, the mechanisms of action specific to the pancreas and beta cells, reductions, gastric emptying, and the upregulation of satiety. We discuss changes in the brain regarding leptin and how these drugs work. We also talk about weight loss resistance, and I answer questions from listeners.  From my perspective, it all comes back to basics. I believe that if we are to prescribe these medications, we must help our patients understand how lifestyle impacts weight-loss resistance and metabolic health. I loved that Dr. Tracy spent some time talking about the specific ways he works with his patients, even before prescribing medications. He also explains how important he feels this drug has been for his patients. I approached today's conversation with an open mind, and I hope you will do the same. IN THIS EPISODE YOU WILL LEARN: GLP1 agonists, and how they help Dr. Tracy motivate his patients to lose weight What are GLP1 agonists, and how do they work? Physical benefits of GLP1 agonists Who is Semaglutide not appropriate for? Common side-effects of GLP1 agonists How those who fail to implement lifestyle changes when they stop using Semaglutide may regain all the weight they lost Hydration while using Semaglutide Protein intake when taking Semaglutide How to follow the metrics that matter Factors that could hinder successful weight loss What Dr. Tracy does to ensure his patients do not regain the weight they lost after they stop using Semaglutide Listener questions: Why is a diabetic drug being used for non-diabetics? Does this drug target muscle versus fat in terms of weight loss? For how long do most patients take it? Are there unique characteristics in perimenopausal and menopausal women that must be accounted for differently? Bio: Dr. Tracy Gapin is a board-certified urologist and a world-renowned expert in men's health and performance, as well as the founder of the Gapin Institute, the global leader in High-Performance Health.  He has over 20 years of experience focused on men's health optimization, human performance, and longevity, providing executives & entrepreneurs a personalized path to fulfill their highest potential. He's been featured in Entrepreneur, Dave Asprey's Biohacking Conference, and as a TEDx speaker. Connect with Cynthia Thurlow Follow on⁠ Twitter⁠,⁠ Instagram⁠ &⁠ LinkedIn⁠ Check out Cynthia's⁠ website⁠ Connect with Tracy Gapin On his⁠ website⁠ ⁠Gapin Institute⁠

Dave Asprey — the father of biohacking — joins me for a deep dive into the hidden operating system that runs the human mind and body. In this conversation, we explore how biohacking can be a doorway to something much bigger: real spiritual awareness, freedom from old survival patterns, and the power of forgiveness. Dave breaks down his “Five F” framework — explaining how our mitochondria run ancient fear programs that shape how we react, think, and relate. He also shares why learning to forgive is the ultimate upgrade for a freer life. In this bitesize you'll hear: How biohacking can open the door to deeper self-awareness The science behind intuition and emotional triggers Tools for releasing old stuck patterns and family baggage Why forgiveness is the real superpower How to rewire your inner operating system so you're not run by fear If you're curious about the crossover between mind, body and spirit — and how to live with more flow and freedom — this one's for you. And if you want to go deeper and explore how to transcend the voice in the head and align with your intuition to get in flow, you can book a free inner consultation with me: https://calendly.com/simon-wgw/find-your-flow-intro-chat My other links: Book: https://www.simonmundie.com/book YouTube: https://tinyurl.com/YouTubeSimonMundie Website: simonmundie.com Substack Newsletter: https://simonmundie.substack.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Fleet Maull, PhD helps overwhelmed founders and entrepreneurs step out of survival mode and into strategic, CEO-level leadership. With 25+ years of experience as a business strategist and founder of multiple mission-driven ventures—including an Inc. 5000 company—he developed a high-impact MBA program for bootstrapped entrepreneurs scaling from 6 to 7 or 8 figures. His approach blends operational strategy with mindset mastery to help leaders beat burnout, build aligned teams, and accelerate growth. A globally respected meditation teacher, Fleet is also the creator of Neuro-Somatic Mindfulness®, a method that integrates neuroscience with contemplative practice to support peak performance. He hosts the Radical Responsibility Podcast, featuring guests like Jack Canfield, Dr. Bessel van der Kolk, and Dave Asprey. As a podcast guest, Fleet brings calm authority and transformative insights on business growth, leadership, and personal evolution. In this episode, Fleet Maull, PhD shares the journey he took to get interested in neuro-somatic mindfulness and radical responsibility, and the role of mindfulness, meditation, gratitude and forgiveness in resolving trauma and living your best life. Learn more about Fleet here: https://www.fleetmaull.com/   Heart Mind Institute: events & more resources - http://www.heartmind.co  Instagram: @heartmindinstitute @fleetmaull Get his book Radical Responsibility and Dharma In Hell: https://www.fleetmaull.com/books Get 15% off Peluva minimalist shoe with coupon code COACHTARA here: http://peluva.com/coachtara CHAPTERS: 0:00 Intro 5:40 Fleet's background 26:40 Neuro-somatic mindfulness 36:32 Radical responsibility 55:00 Forgiveness & gratitude 57:00 Resoursces

Dave Asprey — best known as the godfather of biohacking — shares how our bodies pick up reality before our minds do, and why learning to trust that quiet signal is such an untapped edge. From his journey as a sceptical computer scientist to becoming a pioneer in wellness, Dave talks about breaking old patterns, handling tough emotions and tuning into the deeper wisdom we all have. Speaking of aligning with out intuition, here is the link to book a free 1:1 coaching consultation with me: https://calendly.com/simon-wgw/find-your-flow-intro-chat My other links: Book: https://www.simonmundie.com/book YouTube: https://tinyurl.com/YouTubeSimonMundie Website: simonmundie.com Substack Newsletter: https://simonmundie.substack.com/ Learn more about your ad choices. Visit megaphone.fm/adchoices

Creatine isn't just for bodybuilders. It's one of the most overlooked, science-backed nootropics for brain optimization, neuroplasticity, mitochondrial energy, and total human performance. This episode reveals why creatine is a non-negotiable supplement for anyone serious about biohacking, longevity, and cognitive upgrades. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey breaks down the myths and truths about creatine, uncovering how it enhances memory, supports your mitochondria, regulates mood, strengthens bones and heart function, and even aids fetal brain development during pregnancy. Drawing from decades of functional medicine, real-world biohacks, and new research featured in the Wall Street Journal, Dave explains how creatine works not only as a muscle booster but as a universal cellular fuel that supports brain benefits, memory improvement, and sleep optimization. You'll learn how to harness creatine for everything from mental performance and mood regulation to faster recovery and better metabolism. Dave covers creatine dosage and timing, how to use creatine loading versus maintenance protocols, and how to enhance creatine absorption by mixing it with hot water or pairing it with glucose and protein to leverage insulin-sensitive pathways. He also shares next-level stacking strategies by combining creatine with caffeine (including Danger Coffee), beta-alanine, nitrates, and electrolytes to maximize both mental and physical results. Whether you're using creatine for brain energy, sprint power, cold therapy performance, or cognitive resilience, this episode delivers practical tools you won't hear anywhere else. If you're following a carnivore diet, in ketosis, experimenting with fasting, or just want to feel sharper and more energized, creatine fits right in. Dave also explores cutting-edge options like GAA creatine, creatine HCL, and intranasal delivery systems, along with key nutrient pairings like TMG and folinic acid to support methylation and avoid side effects. Plus, he explains why vegetarians and vegans may need creatine the most. This is your complete guide to creatine brain benefits, mitochondrial support, memory enhancement, and smarter not harder living. You'll Learn: • How creatine supports neuroplasticity, brain energy, and cognitive function • Why mitochondrial health is the key to memory, mood, and mental performance • The real science behind creatine dosage, absorption, and stacking strategies • How creatine fits into ketosis, fasting, and a carnivore lifestyle • Why vegans and vegetarians may suffer from creatine deficiency • How to combine creatine with caffeine, nitrates, and nootropics for peak performance • Ways to biohack your metabolism, muscle growth, and mental clarity • The link between creatine, sleep optimization, and reduced brain fog • How creatine protects against oxidative stress and supports longevity • What you need to know about GAA creatine, methylation support, and delivery mechanisms Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - Calroy | Head to https://calroy.com/dave for an exclusive discount. - BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. Resources: • Danger Coffee: https://dangercoffee.com • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:14 Creatine for Overall Health and Longevity • 06:10 Addressing Common Myths About Creatine • 08:55 How to Use Creatine Effectively • 19:58 Special Use Cases and Recommendations • 24:58 Choosing the Right Creatine • 28:41 Conclusion and Recap See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if death isn't inevitable but a solvable problem? This episode explores how biohacking is reshaping our understanding of mortality, legacy, and the limits of human performance. You'll learn why some of today's top thinkers are treating longevity as both a science and a spiritual movement, and how this shift affects your brain, your mitochondria, and your entire approach to life. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with philosopher and best-selling author Dr. Stephen Cave, Director of the Institute for Technology and Humanity at the University of Cambridge. With decades of expertise studying death, immortality, and ethics, Dr. Cave brings a rare depth of insight into how our desire to live longer intersects with neuroplasticity, supplements, and even nootropics. Together, they unpack the four universal immortality narratives, the dangers of mind uploading, and why AI might become humanity's next god or destroyer. You'll discover how legacy, ego, functional medicine, and even fasting and ketosis play into our fear of death. The conversation also dives into the deeper psychological and societal consequences of radical life extension, and what happens when biohacking crosses into belief. This episode is a must-listen for anyone serious about hacking longevity, brain optimization, metabolism, and building a future where living to 180 isn't science fiction. You'll also hear surprising thoughts on Danger Coffee, RFK, sleep optimization, and how to approach mortality using the Smarter Not Harder mindset. You'll Learn: • Why all technology is a form of life extension • How ego and boredom threaten longevity more than disease • The real dangers of digital immortality and uploading consciousness • Why procrastination could be the enemy of eternal life • How to balance transhumanist tech with human values • The surprising connection between cold therapy, supplements, and meaning Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. SPONSORS: Puori | Head to http://puori.com/dave for 20% off, including subscriptions. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Stephen's Website: https://www.ith.cam.ac.uk/staff/stephen-cave • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:09 Intro • 01:39 Life Extension Challenges • 02:05 Boredom and Mental Health • 04:28 Immortality vs. Enlightenment • 06:21 Death's Role in Civilization • 09:06 Life Stages and Aging • 10:41 Global Immortality Narratives • 15:50 Personal Takes on Immortality • 20:46 Biohacking and Longevity • 28:43 Transhumanism Today • 31:00 Techno-Utopianism and Happiness • 32:20 Wealth and Fulfillment • 32:54 Purpose and Meaning • 34:00 Legacy and Death • 36:33 Near-Death and Mortality • 37:52 Time and Procrastination • 42:00 AI and Human Future • 45:56 Ethics of Life Extension • 50:35 Autonomy and Mortality • 52:35 Dangerous Ideas in Longevity • 55:53 Advice for the Young See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You feel stiff, tired, or older than you should—and this episode shows you how to reverse it. Learn how to fix joint pain, restore youthful movement, and upgrade your longevity by hacking the hidden causes of early aging like mitochondrial dysfunction, leaky gut, and chronic inflammation. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Gregory Kelly, SVP of Product Development at Qualia Life and a leading authority on functional medicine, nootropics, and anti-aging science. Dr. Kelly is a naturopathic physician, author of Shape Shift, former editor of Alternative Medicine Review, and a university instructor who's published over 30 peer-reviewed papers and contributed to the Textbook of Natural Medicine. His deep expertise spans cellular regeneration, sleep optimization, metabolism, and the chronobiology of performance. They reveal why most joint pain has nothing to do with age, why your cartilage and synovial fluid become insulin resistant, and how biohacking your gut can dramatically improve joint function and brain optimization. You'll discover how neuroplasticity, metabolism, sleep, and mobility are all tied to your ability to stay pain-free and high performing. Dr. Kelly also breaks down the science behind unconventional joint-support compounds like tamarind seed extract, eggshell membrane, L-carnitine, and senolytics. You'll Learn: • Why joint pain is often a metabolic and mitochondrial issue, not aging • How zombie cells and gut toxins silently destroy your cartilage • What to take instead of glucosamine to actually rebuild your joints • Why most joint supplements fail and what new research says to use instead • How to enhance mobility using functional medicine and cutting-edge ingredients • How movement, inflammation, and brain health are deeply connected • Tools for real recovery without burnout using the smarter not harder method This channel explores how ketosis, fasting, cold therapy, and smarter not harder strategies affect movement, inflammation, and longevity. Dave also shares how Danger Coffee and his own supplement routines helped him reverse years of joint damage—and how you can do the same without drugs or surgery. This is essential listening for anyone serious about biohacking, human performance, and outsmarting the aging process at any age. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Qualia's Website: https://www.qualialife.com/ • Qualia's Instagram: https://www.instagram.com/qualialife/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:07 Joint Pain vs. Aging • 04:46 Gut-Joint Connection • 06:33 Diet's Impact on Joints • 10:14 Smarter Joint Supplements • 19:15 Senescent Cells and Pain • 22:47 Collagen Breakdown • 24:21 Tamarind and Turmeric Benefits • 26:34 Inflammation Fixes • 29:39 Mobility and Movement • 38:26 Sleep and Joint Recovery • 42:52 Can You Reverse Joint Damage? • 44:48 Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

93% of people are metabolically unhealthy, and it's not because they're lazy or eating too much fat. It's because their bodies forgot how to burn fat at all. This episode gives you a complete roadmap to reboot your metabolism, escape the sugar-burning trap, and reignite your fat-burning engine for good. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Ben Azadi, functional health expert, best-selling author of Metabolic Freedom, and one of today's most trusted voices in the ketogenic and fasting space. After reversing his own obesity through biohacking and functional medicine, Ben has helped millions unlock metabolic flexibility and master human performance through smarter-not-harder strategies. They explore how high insulin, not fat or salt, drives most chronic disease, and why your doctor probably isn't testing for it. You'll learn the truth about seed oils, fructose, and blood sugar spikes, and why most people using continuous glucose monitors are still missing the real metabolic threat. You'll also discover how to: • Switch out of sugar-burning mode and back into fat-burning ketosis • Use fasting, cold therapy, and sleep optimization to repair mitochondrial damage • Fix hidden nutrient deficiencies with the right supplements, potassium, and electrolytes • Build real metabolic resilience with Danger Coffee, functional medicine, and nootropics • Avoid the trap of endless keto or carnivore and learn how to cycle your way to true metabolic freedom • Understand why low HRV, high insulin, and sleep debt crush longevity, energy, and brain optimization • Decode how neuroplasticity, emotional regulation, and resilience all connect to metabolism This is your science-backed guide to transforming your energy, losing stubborn fat, and becoming metabolically unstoppable. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 for 20% off your first order of PerfectAmino. - IGNITON | Go to https://www.igniton.com/ Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Ben's New Book - Metabolic Freedom: A 30-Day Guide to Restore Your Metabolism, Heal Hormones & Burn Fat: https://www.amazon.com/Metabolic-Freedom-Restore-Metabolism-Hormones/dp/1401994369 • Ben's Instagram: https://www.instagram.com/thebenazadi/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:04 Intro • 02:42 Insulin Explained • 06:00 Salt vs. Potassium • 08:10 Uric Acid & Fructose • 12:56 Health Trolls • 18:14 Seed Oil Truth • 24:24 Cooking Oil Breakdown • 31:08 Carnivore & Flexibility • 34:57 Gut Test Insights • 36:09 Cholesterol Panel • 36:43 LMHR Explained • 37:39 Inflammation Markers • 40:25 Managing Autoimmunity • 42:07 Gut Bacteria & Fiber • 46:55 Fasting for Gut Health • 48:03 Saturated Fat & Gut • 49:34 Oxalates & Diet • 57:32 Metabolic Efficiency • 01:03:08 Hormesis & Stress • 01:08:21 Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You're working out, eating clean, and still not getting the results you want. This episode reveals the real reason your fitness isn't translating to the summer body you're chasing and what to do instead. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with performance-driven entrepreneur and former Army Ranger Nick Bare, founder of Bare Performance Nutrition and the Go One More movement. With over a decade of experience in human performance, endurance, and mindset training, Nick has built a cult-like following by pushing the limits of physical and mental resilience without burning out. In this episode, you'll learn why consistency beats intensity, how to spot the traps of overtraining, and how to train smarter by understanding mitochondria function, recovery science, and sleep optimization. Dave and Nick go deep on longevity tactics, cold therapy, neurohacking rituals, and why emotional regulation is the missing link in high performance. They also break down elite strategies for entrepreneurial stress, parenting under pressure, and how to balance ambition with recovery using tools from biohacking, self-quantification, and functional medicine. You'll get practical insights into how Upgrade Labs, Danger Coffee, and the principles behind Smarter Not Harder can dramatically boost your energy and focus. Whether you're an endurance athlete, a sleep-deprived parent, or a business builder trying to avoid burnout, this conversation gives you the blueprint for sustainable energy, powerful willpower, and next-level fitness that actually works. You'll Learn: • The true cost of overtraining and how to avoid it • How to create “sprints” in life without sacrificing long-term performance • Tactical upgrades for training, sleep, fasting, and emotional recovery • What most people get wrong about motivation and discipline • How to use nootropics, cold therapy, and fasting to accelerate growth • Why fear of mediocrity can be fuel if used correctly • How testosterone, cortisol, and dopamine affect parenting, performance, and purpose Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order -Active Skin Repair | Visit http://activeskinrepair.com/ to learn more and use code DAVE to get 20% off your order. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Nick's Website – https://www.nickbare.com/ • Nick's Instagram: https://www.instagram.com/nickbarefitness/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 00:55 Intro • 02:59 Longevity & health • 07:51 Endurance vs recovery • 20:23 Focus & boundaries • 23:16 Pain & recovery • 24:48 Dopamine & motivation • 25:48 Breath work & states • 28:24 Endurance as meditation • 30:44 Curiosity & fear • 32:22 Purposeful suffering • 33:33 Vision quests • 40:18 Nervous system switching • 45:59 Decision-making • 47:59 Final thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your everyday habits might be accelerating aging, and this episode reveals what to do instead. You'll learn how specific plants trigger powerful longevity pathways and how to eliminate the hidden toxins disrupting your hormones, brain, mitochondria, and overall health. This is a masterclass in biohacking from two experts who've spent decades researching how to upgrade the human body. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Darin Olien, environmental health expert, bestselling author of Fatal Conveniences, and co-host of the Netflix series Down to Earth with Zac Efron. Darin has traveled the globe uncovering forgotten plant compounds, investigated the most overlooked environmental toxins, and now works with leading scientists and governments to bring these breakthroughs into functional medicine and human performance. Together, they break down: • How rare plant compounds like osmotin support adiponectin and mitochondrial repair • Why PFAS, synthetic fragrances, and EMFs are sabotaging your biology • How environmental toxins contribute to hormone disruption and infertility • What makes tap water so dangerous and how to fix it with simple filtration • Why microplastics and heavy metals are harder to avoid than ever • The role of habit design, detox protocols, and indoor air quality in biohacking longevity • Why removing toxins first leads to better results in fasting, ketosis, nootropics, and cold therapy This episode delivers practical tools for building resilience, improving detox capacity, and navigating the modern world with awareness. You'll also get insights into the systems that have failed to protect public health and how personal action can create collective change. If you're interested in senolytics, sleep optimization, neurohacking, and smarter ways to upgrade your environment, you'll find those topics explored in depth throughout this channel. Whether you're detoxing from hidden toxins or optimizing with Danger Coffee, this conversation aligns with the core principles of Smarter Not Harder and the mission of Upgrade Labs. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: -OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. -Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. -Apollo Neuro | To get an Apollo wearable, go to https://apolloneuro.com/Dave and save 15%. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Darin's Website – https://superlife.com/ • Darin's Instagram: https://www.instagram.com/darinolien/ • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:10 Intro • 02:14 Meet Darin Olien • 04:26 Wildfires and Pollution • 07:13 PFAS and Everyday Toxins • 12:37 Corporate and Regulatory Failure • 26:36 Synthetic Fragrances • 36:12 Water and Air Filtration • 36:53 Indoor Air Quality • 38:33 Building Healthy Habits • 40:05 Essential Oils and Hormones • 41:54 Tofu, Tempeh, and Estrogen • 46:34 Adiponectin and Biohacking • 47:04 Osmotin for Longevity • 49:48 Stem Cells and Repair • 53:57 Communicating Science • 01:04:12 Nutrition and the Microbiome • 01:06:14 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your anti-aging skincare routine might be secretly aging you faster. In this episode, you'll uncover how trending skincare products including vitamin C serums, harsh exfoliants, and blue light therapies can damage your skin's mitochondria, accelerate senescence, and trigger systemic inflammation. You'll learn how to reverse this damage, support cellular repair, and choose smarter formulations that work with your biology for long-term skin and brain health. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Amitay Eshel, a pioneer in biohacking skincare and founder of Young Goose. With expertise in regenerative aesthetics and advanced bioactive formulations, Amitay is leading the charge in applying longevity science, epigenetics, and senolytics to skincare. His work helps high performers integrate topical nootropics, mitochondrial support, and neurohacking principles directly into their daily routine through the skin. You'll explore how skin aging connects to brain inflammation, how leaky skin barriers affect immune health, and why most anti-aging trends are outdated or biologically disruptive. The Human Upgrade unpacks how red-light therapy, ketosis, cold therapy, fasting, and self-quantification tools can be leveraged to enhance skin function from the inside out. This is a masterclass in smarter not harder skincare, rooted in cellular optimization and performance longevity. This episode is essential listening for anyone serious about biohacking, human performance, skincare longevity, mitochondria, Upgrade Labs-style recovery, and science-backed beauty routines. You'll learn: • Which anti-aging skincare trends actually age you faster • How mitochondria and senescent cells influence visible aging and inflammation • What role neurohacking and the skin-brain connection play in longevity • How to repair the skin barrier and reduce oxidative stress naturally • The best red light, cold therapy, and fasting tools to reverse skin aging • How to use skin as a self-quantification tool for overall health • Why smarter skincare equals better cognitive and biological performance Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: -OneSkin | Get 15% off your first purchase at https://oneskin.co/ASPREY with code ASPREY. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Young Goose Website – https://www.younggoose.com/ and use code “Dave10” at checkout to get a discount! • Young Goose Instagram: https://www.instagram.com/young_goose_skincare/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 – Trailer • 00:52 – Intro • 01:27 – Anti-Aging Mistakes • 05:20 – Skin Recovery Science • 07:44 – NAD & Mitochondria • 08:52 – Autophagy Compounds • 12:06 – Sleep & Topicals • 18:36 – Overtraining Effects • 21:07 – Vitamin C & Antioxidants • 28:48 – Breakthrough Formulations • 35:50 – Tallow vs. MCT • 36:11 – Sun & Longevity • 37:28 – Red Light Therapy • 40:12 – UV Light Benefits • 42:18 – Advanced Skincare Tech • 48:48 – NAD Topicals • 01:00:05 – Building Your Routine • 01:07:39 – Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most supplements don't work, and this episode reveals why. You'll learn how to stop wasting money on “expensive pee,” how to spot marketing lies on labels, and which ingredients actually move the needle for energy, focus, and longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Jeff Boyd, founder of MTE and a leader in the new wave of performance supplements. With a background in data-driven wellness and a decade of experience optimizing human performance without caffeine or sugar, Jeff breaks down the science of nootropics, adaptogens, and smart nutrient stacking. His work focuses on self-quantification, nervous system regulation, and sustainable energy for founders, athletes, and high performers. Together, they explore why 85% of supplements are designed to fail, how to activate mitochondria for real results, and what it means to biohack your biology smarter, not harder. This isn't just about supplements. It's about reclaiming your energy, upgrading your brain, and aligning your stack with how your body actually works. You'll also hear how fasting, sleep optimization, and even subtle neurohacking protocols support long-term resilience and better decision-making. You'll Learn: • The real reason most supplements don't absorb and how to fix it • How to build a caffeine-free stack that fuels energy, mood, and clarity • The latest in adaptogens, nootropics, and functional medicine • How to align your supplement timing with circadian biology and ketosis • Why “clean labels” often mean nothing • How emotional regulation and neurotransmitters shape performance • Tools for self-quantification and supplement personalization This is essential listening for anyone serious about biohacking, longevity, smarter supplementation, mitochondrial health, sleep optimization, emotional resilience, and conscious human performance. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks questions no one else dares and brings you real tools to become more resilient, aware, and high performing. Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • MTE website – www.getmte.com • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 01:13 Saffron Benefits • 02:26 Medicinal Herbs • 04:12 Supplement Formulation • 13:16 Theanine & GABA • 20:06 Adaptogens & Performance • 23:23 Stress & Muscle Growth • 24:03 Parenting & Energy • 27:47 Nervous System for Kids • 35:15 Sleep for Families • 36:41 Wrap-Up & Offers See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Psychedelic therapy is on the verge of reshaping mental health, trauma healing, and human consciousness. This episode reveals what's really happening behind the scenes at the FDA, inside pharmaceutical companies, and within the global movement to legalize MDMA-assisted therapy. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Rick Doblin, PhD, the legendary founder of MAPS and one of the most influential figures in psychedelic science. With nearly 40 years leading clinical research on MDMA, psilocybin, and trauma healing, Rick brings unmatched insight into how these compounds are transforming functional medicine, emotional resilience, and neuroplasticity. They break down the regulatory battle over MDMA therapy, the clash between pharmaceutical profit and public benefit, and the urgent need to combine pharmacology with therapy for real results. You'll also learn how psychedelics impact neurohacking, epigenetics, and the default mode network—and why the next frontier of self-transformation may be couples therapy with MDMA. This episode offers critical knowledge for anyone serious about biohacking, trauma release, mental performance, and accessing deeper states of healing. This podcast channel dives into the intersections of psychedelics with fasting, ketosis, cold therapy, and self-quantification—and how altered states can unlock more energy, better relationships, and lasting change. You'll Learn: • Why separating therapy from psychedelics is the most dangerous path forward • How MAPS evolved into a public benefit pharma company—and what went wrong • The real story behind the FDA's rejection of MDMA therapy in 2024 • How MDMA affects neuroplasticity, mitochondria, and trauma recovery • Why group therapy and couples therapy are the future of psychedelic healing • The dangers of overusing ketamine—and how it's being exploited by profit-driven clinics • What the Psychedelic Science 2025 conference will reveal about the future of medicine, spirituality, and consciousness hacking • How psychedelics could reverse epigenetic trauma passed down through generations • The role of default mode network suppression in spiritual experiences and trauma resolution • Why the war on drugs was never about safety—and what a post-drug-war world might look like Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, neurohacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - Leela Quantum Tech | Head to https://leelaq.com/DAVE for 10% off- ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Psychedelic Science Conference 2025 Website – https://www.psychedelicscience.org/ • Rick's Website: https://maps.org/ • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 02:00 Intro • 03:43 Rise of Psychedelic Pharma • 05:00 Therapy vs. Profit • 06:44 Neurofeedback + Psychedelics • 08:28 Origins of Drug Laws • 14:06 MDMA Safety + Usage • 16:32 Psychedelics in Therapy + Meditation • 25:18 Psychedelic Hierarchy for New Users • 26:51 Psychedelic Churches + Culture • 28:58 Ayahuasca: Spiritual Insights • 30:24 MDMA and Federal Policy • 31:09 Inside the FDA Decision • 32:52 Therapeutic Promise of Psychedelics • 34:43 Psychedelics + Spirituality • 37:37 Neuroscience of Psychedelics • 40:12 Epigenetics + Generational Trauma • 43:50 War on Drugs Revisited • 46:37 Future of Legalization • 49:55 MDMA for Couples • 51:29 Group Therapy with Psychedelics • 52:26 Psychedelic Science 2025 Preview See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You've been told to eat clean, but what if your “healthy” foods are wrecking your gut, crushing your hormones, and aging you faster? This episode exposes the nutrient-depleted truth behind modern diets, soil erosion, and why regenerative farming might be the key to reversing chronic disease, boosting mitochondria, and rebuilding your biology from the ground up. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Josh Axe, a trusted pioneer in functional medicine, bestselling author, and co-founder of Ancient Nutrition. Dr. Axe bridges the gap between biblical farming, ancestral nutrition, and modern science to explain how your food and even your supplements may be harming your human performance, digestion, and brain health. With clinical insights, personal stories, and science-backed tools, he shares what to eat instead if you want real longevity, energy, and healing. They dig into the collapse of soil nutrients, how monocropping damages the microbiome, and why organic food standards may be outdated. You'll learn how regenerative agriculture rebuilds the earth and your gut, and why biohacking starts with dirt, not pills. Plus, they explore the hormonal chaos caused by seed oils, plastics, blue light, sleep disruption, and even birth control, especially in relation to testosterone loss in men and women. This episode also touches on biblical nutrition, fasting cycles, natural nootropics, testosterone-supporting peptides, the dangers of synthetic vitamins, and the future of real-time self-quantification. From poop-powered farming to smarter sourcing, it's a wild ride into how food, faith, and farming affect every part of your biology. This is essential listening for anyone serious about biohacking, neurohacking, longevity, Upgrade Labs, Danger Coffee, Smarter Not Harder, and understanding the real root of disease and dysfunction. You'll Learn: • Why regenerative farming beats “organic” for health and the planet • How depleted soil is linked to hormone imbalances and chronic disease • What birth control is doing to testosterone, fertility, and mitochondrial health • Why your supplements may just be “expensive pee” • The truth about biblical farming and why dirt still matters • How to support testosterone naturally with diet, peptides, and habits • Why sleep optimization, mineral balance, and circadian alignment are key for healing Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. - Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order Resources: • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Josh Axe's Website – https://thehealthinstitute.com/ • Josh Axe's Instagram: https://www.instagram.com/drjoshaxe/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 00:52 Intro • 01:01 From Medicine to Farming • 02:21 Regenerative Farming • 03:36 Fixing Modern Agriculture • 05:43 Biblical Farming Meets Modern Science • 08:23 The Truth About Organic Food • 12:41 What's Causing the Testosterone Crash • 18:07 Hormonal Birth Control • 27:37 New Hormone Replacement • 29:58 The Future of Health Tracking • 32:00 What Is Biblical Farming? • 33:38 Biblical Principles of Nutrition • 33:55 Foods Most Mentioned in the Bible • 35:17 Pork, Parasites, and Dietary Laws • 37:29 Chinese Medicine's View on Pork • 39:36 Did the Flood Shorten Human Lifespan? • 42:26 Biodynamic Farming and Spirituality • 54:27 Fatherhood and Words That Heal • 56:21 What Josh Feeds His Kids • 01:03:41 Mental Health, Faith, and Healing • 01:05:36 Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How do you get on the fast path to unlimited energy, happiness, and inner peace? Dave Asprey, serial entrepreneur, founder of Bulletproof Coffee, renowned podcaster, NYT bestselling author is known as the “father of biohacking" for his decades of exploration into how humans can push the physical and mental boundaries of their potential. He shares what he's learned from writing his latest book Heavily Meditated, including how ancient wisdom and cutting-edge science can help us rewire our triggers, what part of your lifestyle you should prioritize first for true wellbeing, how to move out of stress and fatigue, and how to unlock your brain's full power. - Join Cathy's book club & book party on June 11th! cathyheller.com/club  - Join This Abundant Life! ⁠cathyheller.com/join⁠ - Start your free trial of the Confetti Collective for bonus episodes, curated collections, and more ⁠cathyheller.com/confetti⁠ - Get your copy of Dave's book, Heavily Meditated: The Fast Path to Remove Your Triggers, Dissolve Stress, and Activate Inner Peace ⁠https://daveasprey.com/heavily-meditated/ ⁠- Listen to Dave's podcast, ⁠The Human Upgrade with Dave Asprey⁠ wherever you listen to podcasts - Follow Dave on Instagram ⁠@dave.asprey⁠ - Get Dave's sleep resources at ⁠https://sleepwithdave.com/⁠ - Thanks Miracle Made! TryMiracle.com/DREAMJOB and use code DREAMJOB to claim your free 3-piece towel set and save over 40% off- Thanks Zocdoc! Zocdoc.com.DREAMJOB to find and instantly book a top-rated doctor today Learn more about your ad choices. Visit podcastchoices.com/adchoices

Dr. Jeff Spencer, fueled by resilience and drive, rose from a childhood marked by poverty and parental neglect to achieve his dream of becoming an Olympic cyclist. He defied the odds through mentorship and relentless discipline, ultimately becoming one of the most sought-after performance coaches for business leaders, entrepreneurs, and elite athletes. In this episode, Jeff shares his Champion's Blueprint framework for setting R.I.G.H.T. goals, mastering focus and preparation, identifying blind spots, and executing like a high performer through all five stages of goal achievement. In this episode, Hala and Dr. Jeff will discuss:  (00:00) Introduction (02:56) Becoming an Olympian Against All Odds (06:59) How Mentorship Fuels Elite Performance (10:38) Why Champions Need a “Corner Man” (15:47) Why Success Is Both a Path and a Process (19:27) Aligning Goals with Mind, Body, and Soul (22:16) The R.I.G.H.T. Goal-Setting Framework (29:33) Spotting Risks and Blind Spots in Goals (39:47) How Legacy Drives Long-Term Performance (50:58) Taking Inventory of Your Resources  (56:00) The Stages of Goal Achievement Dr. Jeff Spencer is an Olympic cyclist turned elite performance coach, author, and international speaker. With a career spanning decades, he has coached luminaries including Tiger Woods, Richard Branson, U2, Dave Asprey, and dozens of top CEOs to accomplish their most ambitious goals. Known as “The Cornerman,” Jeff specializes in helping champions and high performers achieve clarity, resilience, and legacy-driven success. His proprietary method, the Champion's Blueprint, offers a proven model for goal achievement and long-term fulfillment. Sponsored By: Shopify - Start your $1/month trial at Shopify.com/profiting. Indeed - Get a $75 sponsored job credit to boost your job's visibility at Indeed.com/PROFITING Mercury - Streamline your banking and finances in one place. Learn more at mercury.com/profiting OpenPhone - Get 20% off your first 6 months at OpenPhone.com/profiting. Bilt - Start paying rent through Bilt and take advantage of your Neighborhood Benefits by going to joinbilt.com/profiting. Airbnb - Find a co-host at airbnb.com/host Boulevard - Get 10% off your first year at joinblvd.com/profiting when you book a demo   Resources Mentioned: Jeff's Book: Turn It Up!, https://www.amazon.com/Turn-Up-Perform-Lifetime-Paperback/dp/B002BN10CG  Jeff's Website: https://www.drjeffspencer.com/    Active Deals - youngandprofiting.com/deals         Key YAP Links Reviews - ratethispodcast.com/yap  Youtube - youtube.com/c/YoungandProfiting  LinkedIn - linkedin.com/in/htaha/  Instagram - instagram.com/yapwithhala/  Social + Podcast Services - yapmedia.com   Transcripts - youngandprofiting.com/episodes-new    Entrepreneurship, entrepreneurship podcast, Business, Business podcast, Self Improvement, Self-Improvement, Personal development, Starting a business, Strategy, Investing, Sales, Selling, Psychology, Productivity, Entrepreneurs, AI, Artificial Intelligence, Technology, Marketing, Negotiation, Money, Finance, Side hustle, Startup, Career, Leadership, Mindset, Health, Growth mindset, Networking, Time Management, Problem Solving, Decision Making, Leadership Skills, Strategic Planning, Mindset, Time Management, Team Building.

Your brain is under constant assault from devices you use every day. This episode reveals the hidden effects of 5G on brain function, cognitive performance, and nervous system stress, along with the science-backed method that neutralizes the damage. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Philipp Samor von Holtzendorff-Fehling, founder of Quantum Upgrade and a former VP at T-Mobile, to explore groundbreaking EEG research that shows how EMF exposure disrupts brainwaves in real time. Philipp shares how new tools are changing the way we approach biohacking, human performance, and energy medicine, and why even hardcore skeptics are paying attention. They break down double-blind studies, ATP production, and real-world EMF mitigation techniques that support brain health, mitochondrial resilience, and recovery. You'll hear why professional athletes, clinicians, and even animals are benefiting from non-invasive approaches once dismissed as fringe, and how to evaluate what actually works in your own biology. This conversation is essential for anyone focused on biohacking, self-quantification, neurohacking, longevity, functional medicine, Upgrade Labs protocols, and protecting the brain in a wireless world. Whether you're optimizing your nervous system, improving sleep, or just trying to stay sharp in a high-EMF environment, this episode gives you a toolset to reclaim your state. You'll learn: • What EEG brain scans reveal after just 30 minutes of 5G exposure • Why ATP production increases in certain energetic fields • How energy fields influence brainwaves, stress, and performance • The connection between EMFs, mitochondrial function, and resilience • Why placebo doesn't explain these results and what that means for self-tracking • How to use energetic tools alongside Danger Coffee, cold therapy, fasting, and nootropics Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday and Thursday, where Dave asks the questions no one else dares and brings you real tools to become more resilient, aware, and high performing. SPONSORS: - Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. - Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Quantum Upgrade Website – Go to https://quantumupgrade.io/Dave for a free trial. • Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/ • Quantum Upgrade Instagram: https://www.instagram.com/quantumupgrade.io/?hl=en • Danger Coffee: https://dangercoffee.com • Dave Asprey's Website: https://daveasprey.com • Dave Asprey's Linktree: https://linktr.ee/daveasprey • Upgrade Collective – Join The Human Upgrade Podcast Live: https://www.ourupgradecollective.com • Own an Upgrade Labs: https://ownanupgradelabs.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen – Neurofeedback Training for Advanced Cognitive Enhancement: https://40yearsofzen.com Timestamps: • 00:00 Trailer • 00:54 Intro • 01:18 Resistance to Energy Work • 03:25 Inner Intuition • 04:22 Science vs Experience • 09:12 Quantum Effects on Body • 13:43 Biohacking for Pets • 15:43 EMFs & Quantum Upgrade • 23:39 Explaining Quantum Tech • 27:58 Understanding Frequencies • 28:53 Scientific Proof & Use • 31:07 Brain Support Tools • 32:28 Ethics & Consent • 34:09 EMF Defense & Biofield • 39:07 Meditation & Altered States • 46:59 Performance Optimization • 48:02 Science Catching Up • 50:39 Free Trial & How to Try See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this episode, Adam and Mayhem break down why more Gen Z workers are abandoning traditional white-collar careers in favor of trade jobs, and they cover the Senate's unanimous approval of a $25,000 tax break for tipped workers—though the bill applies only to cash tips.Later in the show, biohacker and entrepreneur Dave Asprey stops by the studio to talk about his new book Heavily Meditated (available now) and his journey from simply wanting to lose 100 pounds to leading a health and wellness revolution. Dave and Adam discuss the myth of the in-shape health inspector, Dave's daily routine, what he eats (and avoids), his commitment to intermittent fasting, and Adam's story about his mother's 19-year junior college journey as a form of avoidance.Listen in as Dave's biohacking mindset collides with Adam's tough-love philosophy, and they explore why your nervous system is like your phone—and why having thousands of unread text messages might actually be a good thing. Get it on.FOR MORE WITH DAVE ASPREY:INSTAGRAM: @dave.aspreyTWITTER: @bulletproofexecBOOK: HEAVILY MEDITATEDFOR MORE WITH JASON “MAYHEM” MILLER:INSTAGRAM: @mayhemmillerTWITTER: @mayhemmillerThank you for supporting our sponsors:BetOnlineCalderaLab.com/ADAMDeleteMe - Get 20% off your DeleteMe plan by texting ACS to 64000Homes.comoreillyauto.com/ADAMSIMPLISAFE.COM/ADAMPluto.tvLIVE SHOWS: June 11 - Palm Springs, CAJune 13 - Salt Lake City, UT (2 shows)June 14 - Salt Lake City, UT (2 shows)June 19 - Las Vegas, NV (2 shows)See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.