Podcast appearances and mentions of Dave Asprey

If you want more time, better energy, and a calmer mind, this episode gives you a blueprint for achieving it. Host Dave Asprey talks with entrepreneur Jonathan Swanson, who explains how delegation functions as a powerful form of biohacking that frees cognitive load, improves sleep quality, protects your mitochondria from chronic stress, and opens space for longevity, brain optimization, supplements, fasting, ketosis, and the full Human Upgrade approach. Jonathan shows how eliminating low value tasks can reclaim hours every day and upgrade your human performance far more than people realize. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Jonathan Swanson is the Founder and Chairman of Thumbtack and Athena, two global companies he scaled to more than one thousand team members each. He has raised over seven hundred million dollars from leading investors including Sequoia Capital, Google Capital, and Blackstone. At Thumbtack he built one of the top marketplaces for local services. At Athena he created an elite academy for executive assistants and leadership development. Jonathan also served in the West Wing for the President's chief economic advisor, giving him rare insight into time leverage, decision making, and performance under pressure. Jonathan breaks down why overloaded to do lists elevate stress hormones, reduce neuroplasticity, interfere with recovery, and sabotage longevity goals. He explains how removing decision fatigue improves metabolism and cognitive function, how AI can accelerate human support instead of replacing it, and why even small forms of leverage increase ambition, resilience, and overall life satisfaction. Jonathan shares real examples from scaling billion dollar companies, building global teams, managing his own health routines, and designing systems that create more time for family, recovery, and meaningful work. You'll Learn: • Why leverage comes before ambition, not after, and how that shift changes what you believe is possible in your life • How Jonathan went from 16 to 18 hour days and polyphasic sleep to becoming a “time billionaire” through ruthless delegation • The cardinal sin of delegation, why doing it yourself feels faster at first, and how that belief traps you in busywork • The stages of delegation, from single tasks to projects to goals to “clairvoyant delegation,” where you first hear about a task when it is already done • How to start at any budget level, from using AI as a starter assistant, to hiring directly on global platforms, to working with a fully trained Athena EA • Practical ways an assistant can support biohacking, sleep optimization, supplements, lab tracking, family logistics, and even creative life projects • How to build trust, set boundaries, and protect security when you work with remote assistants who have access to sensitive parts of your life• Why human plus AI assistants beat AI alone, and how the next generation of support will supercharge human performance instead of replacing it • How to think about your hourly rate so you stop doing tasks that kill your metabolism, focus, and long term longevity Thank you to our sponsors! -BEYOND Conference 2026 | Register now at https://beyondconference.com/ -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. -Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. -Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body's really doing behind the surface. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: time leverage, personal delegation, executive assistant training, Athena assistant, cognitive load reduction, decision fatigue relief, daily workflow optimization, biohacking time freedom, human plus AI support, inbox offloading, calendar management, task automation, overwhelm reduction, founder performance, global talent recruitment, delegation ladder, clairvoyant delegation, lifestyle efficiency, home logistics support, entrepreneurial time scaling Resources: • Athena Website: Go to https://athena.com/upgrade for a generous discount! • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:30 - Introduction 2:44 - From 18 Hour Days to Delegation 6:42 - Dave's EA Journey 10:43 - Overcoming Shame 12:21 - Finding Trust 15:00 - Delegation Options 18:20 - Never Lift a Finger 22:32 - Clairvoyant Delegation 27:58 - Human + AI Future 30:42 - Security and Boundaries 43:10 - Creative Uses 47:24 - Night Watch 51:37 - Do Less, Do More See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your jaw influences far more than your face. This episode shows you how jaw strength shapes cognition, posture, airway health, sleep, metabolism, and overall human performance. You will learn how targeted jaw training increases cranial blood flow, improves neuromuscular coordination, strengthens airway stability, and stimulates facial muscles that modern diets no longer challenge. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Brandon Harris, founder and CEO of Jawzrsize. Brandon developed the device after multiple severe injuries, including a shattered jaw, months of immobilization, and a 13 day coma. His recovery forced him to rebuild his jaw strength from zero and revealed how deeply the jaw affects posture, oral health, proprioception, and cognitive function. Brandon's experience as a mixed martial artist and his early training of the masseter muscle guided the creation of a safe, medical grade jaw resistance system that now has small clinical data supporting improvements in strength, facial tone, Bruxism relief, and TMJ balance. You will hear how jaw alignment influences the nervous system, why weak jaws contribute to sleep apnea, how saliva flow ties oral health to gut health, and why resistance training for the jaw produces structural benefits the modern soft diet fails to provide. Host Dave Asprey explains how full range jaw training supports cranial stimulation, nitric oxide signaling, fascia activation, posture correction, and neuromuscular coordination throughout the body. This episode also explores how jaw mechanics connect to biohacking principles like brain optimization, sleep optimization, longevity, neuroplasticity, metabolic signaling, and strength based anti aging. This is essential listening for anyone focused on biohacking, human performance, posture mechanics, airway stability, TMJ function, oral microbiome health, anti aging, supplements that support structural function, nervous system training, and practical tools that create fast visible results. You'll Learn: • Why jaw strength acts as a foundational marker for performance and longevity • How jaw alignment shapes posture, proprioception, and neuromuscular firing • Why weak jaws contribute to sleep apnea, snoring, and airway collapse • How jaw training improves Bruxism, clenching, and TMJ tension • What increased cranial blood flow does for cognition and focus • How saliva production supports oral and gut health • Why modern diets shrink facial structure and weaken masseter strength • How jaw resistance training improves facial tone and reduces wrinkle depth • Why athletes use jaw activation to sharpen hand eye coordination • How range of motion training strengthens bone through piezoelectric signaling • Why even five minutes a day creates noticeable results in facial tone and alignment Thank you to our sponsors! -HeartMath | Go to https://www.heartmath.com/dave to save 15% off. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: jaw strength training, TMJ alignment exercise, cranial blood flow stimulation, facial muscle resistance training, bruxism clenching relief, sleep apnea jaw support, oral microbiome improvement, saliva flow activation, jaw posture neuromuscular signaling, masseter hypertrophy training, facial tone anti aging, proprioception jaw connection, airway stability strengthening, hunters gatherers chewing mechanics, tongue plate neck activation, molar alignment biomechanics, jaw range of motion training, piezoelectric bone stimulation, oral health gut health pathway, forward jaw positioning airflow Resources: • Go to https://jawzrsize.com/ ‘Dave15' for 15% off! • Dave's Biohacking Holiday Gift Guide | Go to https://daveasprey.com/giftguide/ to explore the full guide. • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:20 - Intro 2:20 - Brandon's Accident and Recovery 5:00 - Jawzrsize Origin Story 6:16 - The Science of Jaw Strength 17:56 - Clinical Results and User Experience 22:48 - Jaw Health, Posture and Systemic Effects 27:54 - Microplastics 35:59 - Athletic Performance and Neuromuscular Strength 52:57 - Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people stay locked in a constant sympathetic state without realizing it, which drains focus, sleep quality, emotional balance, and long-term resilience. This episode gives you a science backed path to retrain your nervous system, improve heart rate variability, and shift out of stress on command using focused ultrasound technology that targets the vagus nerve. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Jon Hacker, CEO of NeurGear and creator of ZenBud. Jon is a biomedical engineer who has dedicated his career to bridging neuroscience and daily wellness. His work includes peer reviewed clinical research on anxiety, PTSD, autonomic regulation, and non invasive vagus nerve stimulation. He is one of the first innovators to bring focused ultrasound out of the lab and into a practical wearable designed to help people regulate state, build resilience, and create more conscious control over their biology. In this conversation, Dave and Jon break down how ultrasound activates the auricular branch of the vagus nerve, why most electrical vagus nerve devices fail, and what actually happens in the first three to five minutes when the system begins shifting out of sympathetic activation. Jon explains how early trauma wires the autonomic system, why chronic stress is often physiological rather than psychological, and how daily stimulation strengthens vagal tone through Hebbian learning. They also explore how HRV reflects hidden state changes, how nervous system training supports clearer thinking and better emotional regulation, and why this type of tech matters as AI, algorithms, and modern stressors continue to push people into dysregulated states. You'll Learn: • Why sympathetic dominance is so widespread in the modern environment • How the vagus nerve influences stress, recovery, inflammation, and emotional balance • What makes focused ultrasound more precise than electrical vagus nerve stimulation • How ZenBud produced a 78 percent remission rate in clinical anxiety research • How early trauma alters autonomic patterns and keeps people in hidden fight or flight • How three to five minutes of stimulation can reset state during panic or overwhelm • Why daily use strengthens vagal tone and builds long term resilience • How HRV training, consciousness practices, and nervous system workouts fit together • Why noninvasive brain interfaces may become the safer future path as AI advances This episode is essential for anyone interested in biohacking, stress physiology, nervous system training, emotional regulation, HRV, meditation, trauma recovery, longevity, and building a more adaptable brain and body. It gives you a practical look at how the autonomic system really works and how focused ultrasound may change the future of human performance. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: focused ultrasound vagus nerve stimulation, autonomic nervous system regulation, sympathetic dominance recovery, auricular vagus nerve activation, heart rate variability training, anxiety remission ultrasound, PTSD autonomic modulation, Hebbian learning vagal tone, parasympathetic state shift, ultrasound neuromodulation research, trauma induced nervous system wiring, panic attack recovery tools, non invasive brain interface, emotional regulation biohacking, stress physiology retraining, early adverse events autonomic impact, vagus nerve inflammation pathway, TBI secondary injury prevention, ultrasound neural action potentials, HRV resilience protocols Resources: • Go to http://www.zenbud.health/dave and use code ‘Dave15' for a discount! You'll also receive: 3 months of ear buds 3 months of silicone gel 1 copy of Heavily Meditated 1 bottle of Daily Zen supplement by Vatellia Life (60 day supply) • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Trailer 2:00 – Intro 8:04 – Understanding Stress and the Vagus Nerve 14:14 – Jon's Story and Why He Built ZenBud 16:17 – How Vagus Nerve Stimulation Works 21:07 – Using ZenBud and Clinical Results 24:23 – Why We're All So Anxious 30:54 – Longevity, TBI and Recovery 44:01 – The Future of Brain Computer Interfaces 50:54 – Closing Thank you to our sponsors! -LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. -TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off. -BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino. -Leela Quantum Tech | Check out all HEAL360 products and research and get 10% off at https://leelaq.com/DAVE. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Want to look fresh, rested, and radiant all holiday season — without adding more to your plate? In this week's episode, I'm sharing my holiday skin glow ritual — from the science of light and sleep to the exact products I'm using to keep my skin calm, lifted, and luminous. You'll learn:

Most people think fasting is just about skipping breakfast. But what if 72 hours without food could actually reverse aging?In this video, Dave Asprey breaks down what really happens when you fast for 3 days—and why short fasts don't reach the deep repair zone your body is built for. You'll learn:The 3 critical stages your body passes through during fastingHow autophagy turns on and begins cellular repairWhat mistakes destroy your progress (like bad refeeding or skipping electrolytes)How to properly prepare, fast, and recover safelyWhy fasting can make your mitochondria stronger, your mind sharper, and your cells younger*** Dave's Biohacking Holiday Gift Guide | Go to https://daveasprey.com/giftguide/ to explore the full guide. ***Timestamps 0:00 - Why 16-hour fasts don't reach real fat burning0:54 - The myth of aging and what doctors overlook1:48 - How modern life damages your mitochondria2:48 - How fasting restores your body's repair mode3:39 - Understanding the phases of fasting4:58 - Why short fasts cut results short5:34 - Day 1 of fasting6:45 - Day 2 of fasting7:22 - Day 3 of fasting8:24 - Common fasting mistakes that harm your body9:35 - How to prepare before your fast10:31 - The right way to refeed afterward11:14 - Listening to your body's signals and responsesThank you to our sponsors! -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle.Resources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: Instagram: https://www.instagram.com/TheHumanUpgradePodcast/ Facebook: https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Vitamin C, copper peptides, and glutathione behave very differently once you understand how skin absorbs nutrients at the cellular level. This episode shows you how to target collagen production, strengthen mitochondria, improve detox capacity, and upgrade skin density with pharmaceutical grade delivery systems that outperform conventional skincare. You learn why most topical antioxidants never reach their intended targets, how intracellular copper changes longevity pathways, why glutathione affects everything from pigmentation to detox, and how to build a streamlined routine that matches the way high level biohackers actually age. These strategies can help you improve collagen, elasticity, hair density, mitochondrial function, and whole body performance with fewer steps and far more impact. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Dr. Nayan Patel, a pharmacist, wellness expert, and industry leader who has worked with physicians since 1999 to design custom medications and patient specific protocols. He has been the pharmacist of choice for celebrities, CEOs, and medical professionals seeking precision level formulations. Dr. Patel is the author of The Glutathione Revolution, which summarizes more than a decade of clinical research on glutathione. His team created a patented transdermal technology that delivers glutathione systemically through the skin, and he has since expanded this work to include advanced peptides and new delivery systems that improve absorption far beyond standard topical products. He also developed the Auro GSH Antioxidant Delivery System, a skincare line that uses pharmaceutical grade ingredients at potent concentrations to achieve deeper penetration and more reliable biological effects. Together they break down why vitamin C acts as a stimulant that drives collagen rather than a classic antioxidant, how GHK copper peptide thickens aging skin, and why retinoids often speed up cell turnover at the cost of long term resilience. Dr. Patel explains the difference between cosmetic grade and injectable grade peptides, why purity matters when a delivery system pushes molecules deep into the skin, and how zinc overuse has created widespread copper deficiency that affects hair, metabolism, and mitochondrial health. Dave shares his own protocols for using GHK, glutathione, and vitamin C, along with practical dosing strategies that create visible changes in skin density within four to six weeks. You will learn: • How vitamin C stimulates collagen and why glutathione regenerates oxidized antioxidants • How GHK copper peptide improves elasticity, firmness, and structural integrity • Why purity, molecular size, and delivery tech determine whether peptides actually reach target tissues • How topical copper supports intracellular stores and influences hair health and metabolism • Why zinc overload causes silent copper deficiency and what it means for longevity • How targeted glutathione improves detox, pigmentation, and oxidative stress • The fastest protocol for visible skin density improvements and how long results take to show • How to combine these tools with lasers and skin procedures for stronger outcomes Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: GHK copper peptide, topical glutathione delivery, dextrin absorption technology, intracellular copper uptake, vitamin C collagen stimulation, antioxidant regeneration, cosmetic peptide purity, injectable grade peptides, zinc copper imbalance, mitochondrial skin health, hair follicle regeneration, oxidative stress reduction, glutathione detox support, peptide based skincare, collagen crosslinking support, DMAE skin firmness, CoQ10 topical benefits, skincare biohacking, longevity dermatology, pharmaceutical transdermal systems Resources: • Go to https://aurowellness.com/ ‘DAVE10' for a discount! • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:30 - Introduction 5:51 - Delivery Technology and How It Works 9:34 - Product Development and Formulations 21:29 - Application and Usage Guidelines 32:17 - Hair Growth and Specific Concerns 37:22 - Copper, Deficiency and Body Systems 40:52 - Special Topics and Protocols 52:00 - Dosing Protocols and Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If you care about longevity, mitochondria, cardiovascular health, or feeling sharper every day, this episode gives you a clear look at the breakthrough technology that could reshape how supplements are made. Host Dave Asprey talks with Ilan Sobel, CEO of BioHarvest Sciences, about a new way to produce plant compounds at industrial scale without ever growing the plant. Their Botanical Synthesis platform creates highly pure, clinically validated molecules that support blood flow, brain function, metabolic health, and cellular energy with remarkable consistency and little to no environmental waste. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Ilan brings more than two decades of experience in global biotech and consumer health, and under his leadership BioHarvest has grown its flagship product VINIA into one of the fastest growing plant-based supplements in North America. He explains how the company uses plant cell biology and AI guided cultivation to deliver resveratrol, polyphenols, and other high value compounds with superior bioavailability, purity, and measurable clinical effects on arterial dilation, driven by increasing nitric oxide and resulting in improving physical energy, mental alertness and reducing oxidative stress You will learn: • Why traditional extraction wastes most of the plant and creates inconsistent supplement quality • How Botanical Synthesis produces highly bioavailable polyphenols without insecticides, herbacides, fungicides, solvents, or worrying about heavy metal levels.• Why VINIA increases arterial dilation, improves blood flow, and supports healthy nitric oxide levels • How reducing ET1 strengthens vascular health in ways typical nitric oxide supplements cannot • Why better blood flow supports brain performance, mental alertness, and daily physical energy • What clinical studies show about resveratrol absorption, bioavailability, and 12 hour activity in the bloodstream • How piceid resveratrol crosses the blood brain barrier to support cognitive function • Why BioHarvest is developing olive cell compounds like verbascoside for liver fat reduction and cognitive aging • How future saffron cell technology may influence mood, stress, and cognitive health • Why this approach offers major advantages for longevity, anti-aging strategies, and high-performance biologyDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: plant cell biology, Botanical Synthesis, Vinia polyphenols, piceid resveratrol, nitric oxide production, ET1 reduction, arterial dilation, vascular flexibility, blood flow optimization, brain oxygenation, cognitive alertness, oxidative stress reduction, bioavailable polyphenols, grape cell technology, olive cell compounds, verbascoside research, saffron cell cultivation, clinical blood flow studies, endothelial function, longevity supplementation **Visti www.vinia.com/Dave - for a generous discount on your next purchase** Resources: • VINIA Website: www.vinia.com/Dave • BioHarvest Website: https://bioharvest.com/• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:30 - How BioHarvest Works 5:23 - Piceid Resveratrol & Clinical Studies 13:37 - Blood Flow & Cardiovascular Benefits 17:08 - Brain Health & Cognitive Effects 20:07 - VINIA Product Line & Pricing 22:33 - Nitric Oxide Mechanism & ET1 26:39 - Chews & Hydration Mix 36:35 - VINIA Heroes Program 41:19 - Olive Cell Technology & Verbascoside 45:13 - Pharmaceutical Implications 51:30 - Saffron Development See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Todd Watts joins me to expose the environmental assault on our bodies that traditional medicine refuses to acknowledge, from crop dusters spraying atrazine to black mold hiding in your walls. After his own health crisis with Lyme disease led him down the rabbit hole of parasites and toxins, he discovered that if you have a pulse, you have parasites, and they're actually absorbing thousands of times their weight in toxins to protect you. We dive into why glyphosate (Roundup) is destroying your gut microbiome, how atrazine is feminizing men and masculinizing women, and the shocking story of a patient having 25+ seizures daily from undiagnosed parasitic infection. Most importantly, he reveals why you can't successfully treat parasites without simultaneously addressing toxins, they work together in ways that will blow your mind. IN THIS EPISODE WE'LL: Discover why 70% of parasites are microscopic and undetectable through standard testing—and what symptoms they're actually causing Transform your understanding of why Ivermectin worked during COVID (hint: it wasn't antiviral—it was treating undiagnosed parasites) Break through the denial about mold toxicity with real patient stories of complete transformation after leaving toxic homes Uncover how glyphosate acts as both an antibiotic AND mineral chelator, destroying your gut while binding essential nutrients Learn the critical connection between environmental toxins and fungal overgrowth that keeps you stuck in the candida cycle forever CHECK OUT THESE EPISODES: Episode 137: Environmental Toxins Are Messing With Your Body, Here's How to Fight Back with Dr. Aly Cohen: https://podcasts.apple.com/us/podcast/episode-137-environmental-toxins-are-messing-with-your/id1678143554?i=1000730936483 Episode 116: Is Mold Silently Wrecking Your Health? How to Detox from Mold with Dave Asprey: https://podcasts.apple.com/us/podcast/episode-116-is-mold-silently-wrecking-your-health-how/id1678143554?i=1000708555274 Links and Resources CellCore Biosciences: https://cellcore.com/ Learn more about Dr. Todd Watts: https://www.drtoddwatts.com/ Let's Connect Podcast: https://podcasts.apple.com/gb/podcast/breast-implant-illness/id1678143554 Spotify: https://open.spotify.com/show/1SPDripbluZKYsC0rwrBdb?si=23ea2cd9f6734667 TikTok: https://www.tiktok.com/@drrobertwhitfield?_t=8oQyjO25X5i&_r=1 IG: https://www.instagram.com/breastimplantillnessexpert/ FB: https://www.facebook.com/DrRobertWhitfield Linkedin: https://www.linkedin.com/in/dr-robert-whitfield-md-50775b10/ X: https://x.com/rob_whitfieldmd Read this article - https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/implant-reconstruction/illness/breast-implant-illness Shop: https://drrobssolutions.com SHARP: https://www.harp.health NVISN Labs - https://nvisnlabs.com/ Get access to Dr. Rob's Favorite Products below: Danger Coffee - Use our link for mold free coffee - https://dangercoffee.com/pages/mold-free-coffee?ref=ztvhyjg JASPR Air Purifier - Use code DRROB for the Jaspr Air Purifier - https://jaspr.co/ Echo Water - Get high quality water with our code DRROB10 - https://echowater.com/ BallancerPro - Use code DRROBVIP for the world's leader in lymphatic drainage technology - https://ballancerpro.com Ultrahuman - Use code WHITFIELD10 for the most accurate wearable - https://www.ultrahuman.com/ring/buy/us/?affiliateCode=drwhitfield

This episode shows you how light, vibration, and frequency-based technology can shift your brain state in minutes, unlock deep neuroplasticity, release stored trauma, and create coherence that normally takes years of meditation or psychedelic training. You will learn how these tools support performance, resilience, mitochondria, emotional regulation, and advanced biohacking. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with master healer Raffaele Gianfrancesco, whose work draws on energy medicine, Egyptian color healing, vibroacoustics, and light based entrainment. Raffaele trained in the Barbara Brennan lineage and spent years developing methods that shut down the default mode network, activate the thalamocortical circuit, and move people into deep meditative and altered states within minutes. His technology has attracted the attention of consciousness researchers, advanced meditation schools, ketamine clinics, and U. S. Air Force programs studying human resilience and pilot performance. Dave and Raffaele break down how vibroacoustic sound, harmonics, cymatics, and flickering light therapy guide the brain into gamma, delta, epsilon, and high resonance states that support clarity, emotional release, and rapid state change. Raffaele explains how vibration affects fascia and trauma storage, how light influences the cerebrospinal fluid and pineal gland, and why coherence is the key to shifting consciousness. They discuss ketamine assisted therapy, remote viewing, the Monroe Institute, the relationship between frequencies and brain states, the history of flickering light therapy, and how certain frequencies help loosen trauma patterns stored in the body. You'll Learn: • How vibroacoustic sound and coherent light shut down the default mode network • Why fascia, trauma memory, and cerebrospinal fluid respond to vibration • How flicker based entrainment maps to gamma, delta, and theta brain states • Why the Air Force studies these tools for resilience and reaction speed • How ketamine combines with vibration and light to improve neuroplasticity • Why coherence, awe, and safety cues are essential for deep emotional release • What cymatics, harmonics, and frequency patterns reveal about consciousness Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: vibroacoustic therapy, flickering light therapy, consciousness technology, brainwave entrainment, cymatics healing, trauma release tools, ketamine neuroplasticity, default mode network reset, cerebrospinal fluid flow, energy medicine, Barbara Brennan healing, harmonic frequencies, gamma brain states, theta induction, somatic healing, astral plane experiences, remote viewing training, Monroe Institute methods, coherence training, vibration based meditation **https://roxiva.com/dave - for $1,000 off when you purchase the light and vibroacoustic bed together. ** Resources: • RoXiva Website: https://roxiva.com/dave • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 - Introduction • 1:14 - Vibroacoustic Technology • 4:08 - Energy Medicine and Healing • 10:06 - Coherence and Harmonics • 13:47 - Flickering Light Therapy • 16:10 - Stanislav Grof and LSD • 18:49 - Soul Sickness and Consciousness • 21:53 - Ayahuasca and Astral Plane • 28:36 - Psychedelics and Ego Death • 31:23 - Ketamine and Neuroplasticity • 37:31 - Trauma and Presence • 41:08 - Harmonics and Brain Frequencies • 44:04 - Flicker Fusion and Safety • 46:43 - Remote Viewing and Monroe Institute • 48:23 - Cerebrospinal Fluid and Consciousness • 50:32 - Product Details and Pricing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Adam Lane Smith The two sides of having too many kids. (2:00) Building legacy. (4:05) The Business Model of Marriage. (5:27) The Equation of a Balance of Hormones and Neurotransmitters. (8:09) Why most women are not afraid to give you the final say, they are afraid they will have NO say. (16:40) The 4 Levels of Safety. (17:47) Asking for help. (23:35) The confusion around men needing to be more emotional. (26:17) Teaching attachment science. (29:24) The 4 Components of Peace. (31:45) Taking the side of the marriage, instead of taking their own side. (35:35) The 4 Levels of Communication. (37:12) Exercises or strategies for better communication with your partner. (39:19) Matching your needs. (43:33) Persuasion. (46:50) Constructive ways to handle conflict. (47:42) Modern challenges with marriages today. (54:08) The importance of having a same sex group of friends. (57:47) It's VITAL to have high-quality/good moral friends who are rooting for your relationships. (1:00:19) Can you have opposite sex friends? (1:02:39) Building systems and teaching people to become independent & thrive in their relationships. (1:04:45) Subscription level friends. (1:05:55) Related Links/Products Mentioned Visit Adam Lane Smith Bundles for an exclusive offer for Mind Pump listeners! ** Code MIND10 for 10% off all courses. ** Visit Legion Athletics for the exclusive offer for Mind Pump listeners! ** Code MINDPUMP for buy one get one 50% off (BOGO 50% off) sitewide + free gift cards on orders $99+. ** BLACK FRIDAY SALE: 60% off ALL Programs, Guides, and MODs **Code BLACKFRIDAY at checkout** Mind Pump Store Sal Di Stefano's Journey in Faith & Fitness – Mind Pump TV Mind Pump Podcast – YouTube Mind Pump Free Resources People Mentioned Adam | Relationship Psychology (@attachmentadam) Instagram Podcast Adam Lane Smith – YouTube Email: support@adamlanesmith.com Dave Asprey (@dave.asprey) Instagram  

In 1999, a Silicon Valley millionaire on the brink of collapse took one mysterious sip atop a frozen Tibetan mountain - and everything changed. That moment sparked a global movement, rewrote the rules of fat and energy, and turned an ancient secret into a modern revolution.00:00 – The Dying Millionaire00:40 – The Mountain That Changed Everything01:30 – The Birth of Bulletproof Coffee02:40 – When the World Took Notice03:45 – The Fat Lie We All Believed04:45 – The Truth About Good Fats06:00 – Escaping the Sugar Trap07:15 – Stop Counting Calories09:00 – Why Inflammation Keeps You Fat10:40 – Eat Less Often, Not Less Food12:00 – The Exercise Myth13:40 – The Hidden Toxins Problem15:20 – Fixing the Root Cause17:40 – The Power of Mitochondria20:00 – One Sip That Changed EverythingThank you to our sponsors! -KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off.-EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: Instagram: https://www.instagram.com/TheHumanUpgradePodcast/ Facebook: https://m.facebook.com/Thehumanupgrade/Resources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people think you need sweat, strain, or long workouts to upgrade circulation, metabolism, and energy. What if your body could unlock all of that while you stand still? This episode reveals how to get a full body workout by doing absolutely nothing, and why a few minutes of targeted vibration can activate nitric oxide, improve microcirculation, calm your nervous system, and relieve the hidden damage from sitting all day. Host Dave Asprey shows you why the simplest biohack in the room might be the most powerful one you are not using. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Tommy Rhee, DC, a board-certified chiropractor known for his innovative approach to sports medicine and regenerative therapy. Dr. Rhee has treated professional athletes, starting NFL quarterbacks, and everyday people who want better mobility and faster recovery. He served as the official team chiropractor for the Tampa Bay Buccaneers and worked with multiple UCLA athletic programs. He also created RheeGen, a patent-pending topical transdermal stem cell cream that introduces a non-invasive path to tissue repair and pain relief. His book, The Future of Regenerative Medicine, outlines how topical stem cell treatments can transform performance and healing. Dr. Rhee's background as a U.S. Navy aircrew member aboard S-3 Viking jets gives him a precision-driven understanding of human performance, resilience, and stress adaptation. In this episode, Dr. Rhee explains why whole body vibration works as a cheat code for circulation, fascia mobility, balance, mood, and nitric oxide activation. He shows how vibration increases microcirculation in places your workouts never reach, why it boosts lymphatic flow better than walking, and how it sends rapid-fire sensory signals that improve proprioception and stress recovery. You also learn why older adults benefit even more from this simple tool, how athletes use it as a warmup to conserve energy, and why three plane vibration dramatically outperforms cheap two dimensional devices. Dave and Dr. Rhee show you how to pair vibration with fasting, ketosis, nootropics, supplements, Danger Coffee, and Smarter Not Harder style training for maximum biohacking efficiency. You'll Learn: • How to mimic the benefits of a full workout while standing still • Why nitric oxide drives circulation, longevity, and metabolic health • How vibration accelerates lymphatic drainage and clears stagnation • Why whole body vibration improves balance, sensory speed, and neuroplasticity • How athletes warm up with vibration to protect energy reserves • Why triplanar vibration beats two dimensional devices for real results • How vibration supports pelvic floor strength and erectile function • How to use vibration for joint protection, fascia mobility, and mitochondrial activation • The daily protocol Dr. Rhee uses for stress relief, mood, and brain optimization Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: vibration plate benefits, power plate workout, whole body vibration therapy, nitric oxide boost naturally, improve circulation fast, lymphatic drainage at home, fix leg swelling quickly, better than walking workout, passive exercise machine, joint friendly fitness, biohacking circulation hack, vibration plate for balance, how to increase microcirculation, proprioception training at home, vibration plate for seniors, rebounder vs vibration plate, fix poor circulation in legs, vibration therapy recovery, power plate warmup routine, best vibration plate for home use **Discount on your next Power Plate: https://powerplate.com/dave ** Resources: • Power Plate Website: https://powerplate.com/dave• Dr. Tommy Rhee's Website: https://rheegen.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 0:45 - Introduction: Whole Body Vibration 2:12 - Biological Activation Explained 4:05 - Nitric Oxide and Circulation 5:57 - Power Plate vs Walking 8:19 - Shearing Force and Fascia 11:25 - Planking and Exercise Variations 13:31 - Common Mistakes 15:03 - Microcirculation and Lymphatics 19:02 - Benefits for Young Athletes 22:15 - Types of Vibration Machines 25:21 - Proprioception and Balance 27:08 - Pro Athletes and Warm-Up 34:08 - Benefits for Women 35:35 - Benefits for Men 36:13 - Mood and Stress Relief 37:21 - Power Plate Deal and Recommendations 38:53 - Frequency Settings 40:58 - Power Plate vs Rebounder 44:03 - Usage for Ill or Elderly 46:53 - Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Prepare to rethink surgery, healing, anesthesia, and recovery. This episode gives you a complete, high-performance playbook for surgical preparation and accelerated healing, built on biohacking, functional medicine, neuroprotection, and mitochondrial resilience. You will learn how to recover up to three times faster, protect your brain from anesthesia related inflammation, and enter any procedure with the stability and metabolic readiness of an elite performer. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Dr. Cameron Chesnut, a facial plastic surgeon trusted by the world's high performers. Patients travel from every corner of the globe for his minimally invasive results that look natural, rejuvenated, and untouched. He is known for progressive regenerative medicine techniques, brain safe anesthesia protocols, advanced postoperative recovery strategies, and a personal commitment to performance readiness that mirrors the mindset of elite athletes. His methods bridge functional medicine, metabolism, supplements, sleep optimization, nootropics, and regenerative science to transform the entire surgical experience. Together, they reveal how to avoid the hidden pitfalls that create postoperative brain fog, inflammation, mitochondrial dysfunction, and slow recovery. You learn how to work with your anesthesiologist, avoid harmful drug combinations, and stack ketones, fasting, NAD, glutathione, stem cell rich fat grafts, IV therapy, and hyperbarics for rapid healing. Dr. Chesnut explains why fillers migrate, why general anesthesia often disrupts cognition, how exogenous ketones stabilize neurons, and how regenerative peptides, ketosis, circadian timing, and nutritional density shift the biology of recovery. You'll Learn: • How Host Dave Asprey prepares his brain and mitochondria before anesthesia • Why standard anesthesia protocols increase neuroinflammation and cognitive dysfunction • How to use ketamine and dexmedetomidine instead of benzos, opiates, and amnesia drugs • Why fillers migrate and how regenerative fat grafting outperforms traditional filler • How exogenous ketones enhance neuronal stability during anesthesia • Why hyperbarics, red light, PEMF, and IV therapy shorten recovery time • How peptides like BPC, GHK copper, and TB4 support tissue repair • Why metabolic health, carnivore leaning nutrition, and real protein accelerate healing• How nicotine influences angiogenesis and when it can help • The real difference between healing fast and healing well • How to structure your recovery environment for sleep optimization and better outcomes • Why elite performers treat surgery like an athletic event and prepare the same way • How to talk to your surgical team so your biology stays protected and optimized Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Regenerative surgery optimization, anesthesia brain protection, postoperative cognitive dysfunction, accelerated surgical healing, functional medicine surgery prep, ketamine conscious sedation, dexmedetomidine anesthesia protocol, mitochondrial recovery support, stem cell rich fat grafting, surgical hyperbaric therapy, exogenous ketone neuroprotection, fasting preparation, nootropic assisted recovery, peptide tissue repair, filler migration correction, angiogenesis enhancement, circadian prep, sleep optimized anesthesia, metabolic healing strategy, nicotine angiogenesis Thank you to our sponsors! -Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. -ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. Resources: • Cameron's Clinic: https://www.clinic5c.com/• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 2:05 - Pre-Surgery Optimization 5:41 - Stem Cells and Fat Transfer 9:28 - Brain Safe Anesthesia 15:43 - Propofol Alternatives 21:06 - Non-Opioid Pain Control 27:22 - Recovery Protocols 29:11 - Xenon Gas Insights 31:02 - Racetams and Brain Protection 33:18 - IV Glutathione 43:24 - Ketones for Surgery 44:06 - Growth Hormone and Peptides 55:57 - Nicotine and Healing 58:37 - Surgical Lighting 1:05:23 - Filler Migration 1:15:18 - Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In the wildly popular biohacking and longevity space, Peter Attia is often cited as one of the leading luminaries. His straightforward, science-backed approach seems to cut through the noise in a space dominated by fit bros and wellness grifters who always seem to have a product to sell. But the man who dropped out of residency at Johns Hopkins to found a private clinic focused on longevity has his share of critics, who are a bit suspicious about his self-experimentations—and the millions he makes counseling Silicon Valley insiders about experimental medicine. This week we take a look at longevity broadly and Attia specifically. Derek kicks off the episode with a recap of his time at Eudemonia Summit, where, among other things, he got to debate another leading biohacker, Dave Asprey, about seed oils. As it turns out, longevity was the top buzzword there as well. I Went to Eudemonia – a Wellness Summit with the Industry's Top Thought Leaders – Here's What It Was Like Outlive: A Critical Review  A Review of OUTLIVE Critiquing Peter Attia Andrew Huberman and Peter Attia: Self-enhancement, supplements & doughnuts? Learn more about your ad choices. Visit megaphone.fm/adchoices

Breathwork is one of the most powerful tools in biohacking, yet most people only experience the surface level techniques. When you use it the right way, breathwork can upgrade your brain, strengthen your nervous system, improve sleep, and open awareness states that amplify longevity and human performance. This episode features Ishan Shivanand, a globally celebrated yogic scholar, mental health researcher, and bestselling author who was raised in the monasteries of India under Mahasiddha Avdhoot Shivanand. He carries one of the world's oldest Shiv Yogi lineages and created the clinically validated Yoga of Immortals method, which has helped millions reverse anxiety, depression, insomnia, burnout, and trauma. Together, Host Dave Asprey and Ishan reveal how lineage level breath practices shape consciousness, neuroplasticity, and emotional resilience. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey and Ishan explore the full arc of ancient yogic training, from how breathwork directs prana through the body to how chanting alters brain states, emotional regulation, and nervous system function. They break down the role of visualization in building neuroplasticity, the symbolism and physics of sacred sound, and the science of moving awareness through the spine. The conversation moves into rarely discussed topics including the yogic art of choosing one's death, how advanced practitioners leave the body, the meaning of immortality in spiritual traditions, and how dharma shapes whether long life becomes a blessing or a burden. You will hear how ancient monks trained through martial arts, mantra repetition, sacred geometry, gold symbolism, alchemy, and the cultivation of higher states of consciousness, and how these practices compare to modern biohacking tools like fasting, ketosis, nootropics, supplements, sleep optimization, functional medicine, and mitochondrial support. This episode shows you how Eastern mystical training and Western performance science intersect and how these teachings fit naturally within the Smarter Not Harder framework. This conversation also covers plant medicine, psychedelics, and the difference between ancient ceremonial use and modern recreational misuse. You will hear how lineage based training uses breath, awareness, and mantra to alter redox balance, regulate the autonomic nervous system, strengthen energy production, and shape brain optimization at the deepest levels. You'll Learn: • Why breathwork changes brain states faster than basic meditation and how it drives neuroplasticity • How chanting affects the vagus nerve, emotional regulation, and nervous system balance • How visualization strengthens nerve pathways, trauma resolution, and sleep optimization • The meaning behind sacred sound, vibration, and the origins of consciousness in ancient lineage training • Why monks train with martial arts, mantra repetition, and sacred geometry to enhance awareness • How yogic philosophy approaches immortality, choosing one's death, and leaving the body consciously • Why dharma shapes whether long life becomes a blessing or a curse • How plant medicine differs when used ceremonially versus recreationally • How to integrate these teachings into your own longevity, performance, and human potential strategy Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: advanced breathwork techniques, prana movement training, mantra induced trance states, sacred sound vibration science, visualization neuroplasticity practice, yogic spinal awareness training, autonomic nervous system regulation, ancient Himalayan lineage meditation, art of conscious death practice, yogic immortality teachings, dharma based longevity strategy, astral body leaving techniques, yogic alchemy and transformation, sacred geometry meditation, pranic channel activation, ceremonial plant medicine use, trauma release breathwork, nervous system coherence chanting, biohacking consciousness optimization, mitochondrial and prana synergy Thank you to our sponsors! -Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body's really doing behind the surface. -Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. -BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino. Resources: • Ishan's Website: https://ishanshivanand.com/ • Ishan's Book ‘The Practice of Immortality' : https://practiceofimmortality.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Meditation Training 4:12 — Chanting and Mantras 8:09 — Jesus in India 10:50 — Coffee and Consciousness 14:54 — Unity of Religions 19:57 — Visualization Practice 22:57 — Gold Symbolism 26:01 — Alchemy and Transformation 28:45 — Psychedelics as Medicine 31:42 — Technology and States 37:43 — Choosing Death 39:12 — Death and Consciousness 43:31 — Dharma and Immortality 45:18 — Art of Dying 51:00 — Longevity and Meditation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Here's the hidden story behind why you can chug “pure” water all day and still feel foggy, drained, and oddly thirsty: most of what we drink is missing something essential. In this video you'll learn what “dead water” really is, how to tell if yours is part of the problem, and the simple shifts that keep your brain sharp, energy steady, and cells fully charged—without gimmicks, hype, or drinking a gallon a day.Chapters:00:00 – The “dead water” problem00:23 – Why minerals matter for your brain, heart & energy01:07 – 5,000 hydration scans: what the data shows01:33 – The 8-glasses myth (and who benefited)03:11 – Bottled water marketing vs reality04:17 – Tap water: safe ≠ complete06:00 – Hyponatremia: when “more water” backfires07:05 – Electrolytes your cells run on07:56 – What to do: filters, mineralizing, simple add-ins09:03 – Timing hydration + daily micro-habitsConnect with Dave Asprey!Thank you to our sponsors! -LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser.-Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave.Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Creatine is being called a "cognitive super-drug" that feels like "speed without the speed." Influencers are telling you to mega-dose 20 grams a day for brain power, bone health, and more. But what does the science actually say?In this episode, we go beyond the hype and fact-check the wildest creatine claims taking over the internet. I break down the real evidence on mega-dosing, and put the cognitive benefits to the testI react to clips from Paul Saladino, Jeff Cavalier, Rhonda Patrick, and Dave Asprey to separate proven fact from marketing fiction. Discover the simple, science-backed creatine protocol that actually works, and save your money (and your gut) in the process.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/00:01:23 - High-Level Reality Check on Creatine00:03:12 - Hosts' Personal Histories with Creatine00:05:17 - How to Evaluate Health Influencers & Their Claims00:08:40 - Paul Saladino (MD): Analysis of Mega-Dosing Claims (20g/day) for Brain & Bones00:23:16 - Jeff Cavaliere (Physical Therapist): Claims on Depression, Parkinson's, and MS00:31:22 - Discussion on Creatine for Sleep Deprivation & High Stress00:34:28 - The "No Downside" Myth & Side Effects (GI Issues, Microbiome)00:37:29 - Rhonda Patrick (PhD): "Feels Like Speed" Claim & Brain Aging00:46:00 - Dave Asprey: "Most Powerful Cognitive Drug" Claim00:53:02 - How Creatine Actually Works (The "Backup Battery" Analogy)00:53:49 - Final Take-Home Messages & Summary00:56:00 - Q&A: Best Time to Take Creatine & What to Do If You Miss a Day00:57:42 - Final Thoughts on Influencer HypeDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/

This episode covers: • Nano CBD Pain Relief Without Cognitive Side Effects A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support. Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm • Moderate Calorie Restriction Slows Biological Aging A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting. Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults • FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer's The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer's disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair. Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/ • Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.” Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged) • Klotho: The Longevity Protein Nears Clinical Reality The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols. Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged) All source links provided for easy reference to the original reporting and research above. This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer's microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates Thank you to our sponsors! LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. Resources: • Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Intro 0:19 — Story 1: Nano CBD for Pain Relief 1:53 — Story 2: Caloric Restriction and Aging 3:20 — Story 3: AI Robotic Surgery for Alzheimer's 4:50 — Story 4: Microbiome Reprogramming 6:05 — Substack Announcement 7:04 — Story 5: Klotho Longevity Protein 8:39 — Weekly Homework 9:31 — Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo masterclass, and this one breaks down how to use methylene blue as a precision tool for brain optimization, longevity, and human performance while avoiding the dosing mistakes that create jitteriness, sleep disruption, or dangerous interactions. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey guides you through more than a century of research on methylene blue. He has been hacking this compound since the early 2000s and brings deep insight into mitochondria, neuroplasticity, metabolism, supplements, fasting, red light, ketosis, nootropics, and functional medicine. You will learn how methylene blue works inside the cell, how it improves electron transport, and why it appears in neurology, psychiatry, and anti aging research at the same time. This episode shows you how to test your own dose, how to stack it with light and ketosis for maximum effect, and how to avoid serotonin syndrome or sleep disruption. Methylene blue also touches nearly every major system that biohackers care about, which is why this solo masterclass shows you how it interacts with mitochondria, neuroplasticity, metabolism, sleep optimization, and long term anti aging pathways. You will hear how it influences redox balance, ATP production, brain optimization, and stress resilience, and how it behaves when combined with ketosis, fasting, creatine, NAD boosters, red light therapy, or other nootropics. Host Dave Asprey explains why methylene blue pairs well with certain supplements but clashes with psychedelics or SSRI medications, how it fits into functional medicine protocols for mitochondrial repair, and how to use data and wearable tracking to dial in your response. This episode gives you a complete framework to evaluate whether methylene blue belongs in your personal longevity strategy and how to use it with precision instead of guesswork. You'll Learn: • Why methylene blue acts like mitochondrial jumper cables and when it improves energy and mood • The exact signs that your dose is too strong, too weak, or in the Goldilocks zone • How methylene blue interacts with neuroplasticity, memory circuits, and cognitive resilience • Why psychedelics, SSRIs, and MAO inhibitors can create dangerous serotonin interactions • How to pair methylene blue with red light therapy, ketosis, creatine, fasting, or NAD boosters • The link between mitochondrial health, fertility, libido, and long term anti aging strategies • How to track sleep optimization, HRV, and performance signals to dial in your personal protocol • The difference between aquarium grade dye and pharmaceutical grade formulations • Why genetic testing for G6PD deficiency is essential before higher dose experimentation Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: methylene blue dosing, mitochondrial electron transport, Complex IV cytochrome c oxidase, redox cycling, MAO inhibition, serotonin syndrome risk, G6PD deficiency caution, neuroplasticity enhancement, dendritic spine density, mitochondrial stress adaptation, red light therapy stacking, cognitive performance optimization, ketone supported ATP production, nitric oxide independent focus boost, mitochondrial bottleneck repair, pharmaceutical grade methylene blue, sleep disruption signals, biohacking fertility support, oxidative stress buffering, functional medicine mitochondria repair Thank you to our sponsors! -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction 4:51 — History of methylene blue 7:38 — How methylene blue works 14:05 — Safety 17:53 — Dosing and timing guidelines 20:41 — Combining with red light therapy 22:41 — Quality and sourcing 23:17 — Dosing protocols 25:24 — Longevity and fertility effects 29:24 — Stacking options 32:10 — Common questions and FAQs 33:40 — Future research and wrap up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Eboni Cornish, Associate Medical Director at Amen Clinics and President-Elect of ILADS, breaks down why Lyme disease is just the beginning of the story. As someone who specializes in neuroinflammation caused by chronic infections, she explains how tick-borne diseases, parasites, and mold toxicity don't work alone. They create an inflammatory cascade that crosses the blood-brain barrier, triggers autoimmune responses, and makes recovery from conditions like breast implant illness exponentially harder. From her work analyzing brain scans showing infection-driven inflammation to her clinical insights on why gut stability determines immune stability, Dr. Cornish provides a masterclass in understanding complex chronic illness. You'll learn why standard testing misses most infections, how genetics determine your susceptibility to toxin accumulation, and why the real question isn't IF you have parasites but how much they're contributing to your inflammatory burden. Dr. Eboni Cornish on Instagram: https://www.instagram.com/dr.ebonicornish/ Amen Clinics: https://www.amenclinics.com/ Amen Clinics on Instagram: https://www.instagram.com/amen_clinics/?hl=en ILADS: https://www.ilads.org/ IN THIS EPISODE WE'LL: Discover why Lyme disease is actually three infections (Borrelia, Bartonella, and Babesiosis) that create different symptoms and require clinical diagnosis beyond lab testing. Uncover the connection between HLA genetics and your ability to clear mold toxins, tick-borne diseases, and why some family members get devastatingly sick while others stay healthy in the same environment. Break through the parasite denial that keeps you sick, including why testing is unreliable and how parasites create biofilms with other pathogens to overwhelm your immune system. Transform your understanding of the gut-brain axis and why stabilizing your microbiome isn't optional if you're dealing with neuropsychiatric symptoms, chronic inflammation, or breast implant illness. Learn practical nutrition strategies that meet patients where they are, from working with picky eaters to creating sustainable anti-inflammatory habits without the stress of restriction-based diets. CHECK OUT THESE EPISODES: Episode 116: Is Mold Silently Wrecking Your Health? How to Detox from Mold with Dave Asprey: https://podcasts.apple.com/us/podcast/episode-116-is-mold-silently-wrecking-your-health-how/id1678143554?i=1000708555274 Episode 137: Environmental Toxins Are Messing With Your Body—Here's How to Fight Back with Dr. Aly Cohen: https://podcasts.apple.com/us/podcast/episode-137-environmental-toxins-are-messing-with-your/id1678143554?i=1000730936483   Links and Resources Let's Connect Podcast: https://podcasts.apple.com/gb/podcast/breast-implant-illness/id1678143554 Spotify: https://open.spotify.com/show/1SPDripbluZKYsC0rwrBdb?si=23ea2cd9f6734667 TikTok: https://www.tiktok.com/@drrobertwhitfield?_t=8oQyjO25X5i&_r=1 IG: https://www.instagram.com/breastimplantillnessexpert/ FB: https://www.facebook.com/DrRobertWhitfield Linkedin: https://www.linkedin.com/in/dr-robert-whitfield-md-50775b10/ X: https://x.com/rob_whitfieldmd Read this article - https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/implant-reconstruction/illness/breast-implant-illness Shop: https://drrobssolutions.com SHARP: https://www.harp.health NVISN Labs - https://nvisnlabs.com/ Get access to Dr. Rob's Favorite Products below: Danger Coffee - Use our link for mold free coffee - https://dangercoffee.com/pages/mold-free-coffee?ref=ztvhyjg JASPR Air Purifier - Use code DRROB for the Jaspr Air Purifier - https://jaspr.co/ Echo Water - Get high quality water with our code DRROB10 - https://echowater.com/ BallancerPro - Use code DRROBVIP for the world's leader in lymphatic drainage technology - https://ballancerpro.com

Bioelectronic medicine is changing how we treat inflammation, autoimmunity, and chronic disease, and this episode shows you exactly how nerve stimulation could redefine human performance, longevity, and brain optimization. You will learn how electricity, neurotransmitters, and targeted neural pathways can replace drugs, control inflammation, and help you hack the vagus nerve with precision instead of guesswork. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Kevin J. Tracey, MD, president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, pioneer of vagus nerve research, and author of The Great Nerve. He is one of the world's most cited scientists in inflammation and neuroscience, and his discoveries created the field now known as bioelectronic medicine. He identified the therapeutic action of anti TNF antibodies, mapped the inflammatory reflex, and revealed how vagus nerve signaling controls immunity. With more than 450 scientific publications and over 120 U.S. patents, he is a trusted authority whose work drives the future of anti-aging, functional medicine, metabolism, and neural therapies. Dr. Tracey and Host Dave Asprey explore how the vagus nerve truly operates, why it contains 200,000 fibers with different functions, and what happens when you stimulate specific pathways that regulate inflammation, HRV, neurotransmitters, and immune signaling. You will learn how nerve impulses transmit information, how voltage gated ion channels shape behavior and biology, and why certain forms of stimulation create measurable improvements in mitochondria, metabolic control, sleep optimization, and emotional regulation. They break down the science behind surgical vagus nerve implants, focused ultrasound, gamma entrainment, cytokine control, and real neuromodulation. They also explore why cold plunging, breath work, HRV training, nootropics, and consumer devices vary so widely in their effects, and how to evaluate these tools with practical biohacking frameworks. You will hear what actually works, what remains experimental, and what the next decade of nerve based therapies could unlock for brain optimization, longevity, ketosis, fasting, supplements, and AI guided interventions in human biology. You'll Learn: • How vagus nerve stimulation reduces inflammation through the inflammatory reflex • Why bioelectronic medicine can replace drugs in autoimmune conditions • How nerve fibers relay electrical and chemical signals inside the body • Why cold immersion, breath work, and HRV training activate specific vagal pathways • How 40 hertz gamma entrainment may influence cognitive decline • Which stimulation methods have clinical validation and which do not • Why high vagal tone is linked to better metabolism, immunity, and emotional stability • What future nerve based technologies may unlock for human performance Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Kevin J. Tracey, vagus nerve stimulation, bioelectronic medicine, inflammatory reflex, SetPoint Medical, cytokine control, neuromodulation therapy, autonomic nervous system, HRV optimization, inflammation reduction, rheumatoid arthritis treatment, focused ultrasound therapy, gamma entrainment, mitochondrial signaling, anti-aging science, neural pathway hacking, functional medicine research, immune system regulation, brain and body performance, human longevity science Thank you to our sponsors! -AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. -MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. -Calroy | Head to https://calroy.com/dave for an exclusive discount Resources: • Learn More About Kevin's Work: https://feinstein.northwell.edu/institutes-researchers/our-researchers/kevin-j-tracey-md • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:12 - Bioelectronic Medicine 3:23 - FDA Approval 6:48 - RA Treatment Explained 11:35 - Vagus Nerve Function 15:12 - External vs Implanted Stimulation 18:06 - Focused Ultrasound 26:11 - Ear Stimulation Science 30:51 - Clinical Evidence 37:10 - Alzheimer's Link 42:15 - Future Applications 46:48 - Cold Exposure Effects 53:51 - Common Misconceptions 55:38 - Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most people don't even know exists, yet it plays a crucial role in how fast (or slow) you age.The twist? You can activate it in just 10 minutes a day, no prescription required.Curious about the biological "switch" that might help you turn back your cellular clock? The answer might surprise you...*Chapters*0:00 – Introduction0:46 – Lobsters and Human Longevity Connection1:14 – Understanding Telomeres and Aging2:26 – How Lobsters Defy Aging3:32 – Rethinking Aging Biology4:53 – The Telomerase Challenge6:43 – Natural Ways to Protect Telomeres9:33 – Meditation's Role in Anti-Aging11:04 – Different Meditation Techniques13:19 – Benefits and Long-Term EffectsResources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com ADS/SPONSORSBodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers.Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast:https://www.instagram.com/TheHumanUpgradePodcast/https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode covers: • Cocoa Extract Cuts Heart Deaths A massive COSMOS trial found that older adults taking high flavanol cocoa extract daily saw a 27 percent reduction in cardiovascular deaths along with drops in inflammation markers like HSCRP. Women showed unique anti inflammatory cytokine shifts, pointing to a broader longevity effect. Dave explains why cocoa extract is becoming a foundational nutrient for vascular health rather than a dessert ingredient. Source: https://www.sciencedaily.com/releases/2025/09/250926135957.htm • AI Stethoscope for Home Diagnostics Lapsi Health's Keikku 2.0 just became the first FDA cleared AI powered digital stethoscope for both clinicians and home users. It records heart and lung sounds, analyzes them instantly, and flags early warning signs before symptoms appear. Dave breaks down why tools like this move you from reactive to predictive medicine and why they belong in every quantified self toolkit. Source: https://www.prnewswire.com/news-releases/lapsi-health-unveils-keikku-2-0-worlds-first-fda-cleared-digital-stethoscope-with-integrated-ai-scribe-302585083.html?utm_source=chatgpt.com • Beef Organ Supplements Surge Beef organ supplements have exploded more than 8,000 percent this year, driven largely by women reporting improvements in energy, hormones, mood, and skin. Liver, kidney, and heart deliver vitamin A, heme iron, B12, copper, and choline that modern diets often lack. Dave covers sourcing concerns, purity standards, and why this shift reflects a move from fear based nutrition to evolutionary nutrition. Source: https://www.verywellhealth.com/beef-organ-supplement-11710185?utm_source=chatgpt.com • Spirulina for Collagen and DNA Protection New research highlights spirulina's ability to support collagen production, reduce oxidative stress, protect DNA, and improve glucose and lipid balance. It is becoming a staple of eco focused anti aging routines and is driving the viral green stacking trend with chlorella and chlorophyll. Dave explains why spirulina functions as a clean daily defense against oxidative stress. Source: https://www.news-medical.net/news/20250707/Is-Spirulina-the-Next-Anti-Aging-Superfood.aspx • Health Data Privacy Reform A new Senate bill aims to extend HIPAA level protections to wearables, genomic tools, glucose monitors, and wellness apps. The goal is to give users control over who sees their biometrics, how they are stored, and whether they can be sold. Dave outlines why this matters for anyone using Oura, Whoop, CGMs, or genetic testing and why your biology should belong to you and not the cloud. Source: https://natlawreview.com/article/federal-healthcare-update-november-7-2025 All source links provided for easy reference to the original reporting and research above. This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: cocoa extract, flavanols, heart health, nitric oxide pathways, COSMOS trial, AI stethoscope, digital diagnostics, Keikku device, predictive health tech, beef organ supplements, women's hormonal health, nutrient dense foods, ancestral nutrition, spirulina benefits, collagen support, oxidative stress defense, green stacking, chlorella pairing, DNA protection, wearable privacy laws, HIPAA reform, biometric data rights, longevity news, biohacking updates Thank you to our sponsors! Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask. Resources: • Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Intro 0:19 – Cocoa Extract & Heart Health 1:52 – AI Digital Stethoscope 3:01 – Beef Organ Supplements 4:24 – Spirulina for Longevity 5:42 – Substack Announcement 6:53 – Health Data Privacy Reform 8:23 – Weekly Upgrade Protocol 9:46 – Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your workouts may be doing less than you think, and science now proves why. This episode reveals how to build muscle, improve metabolism, and extend longevity in a fraction of the time using blood flow restriction training and intermittent hypoxia. You'll learn how to hack your mitochondria for faster recovery, stronger hormonal balance, and better brain performance without the burnout of high-intensity training. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Dr. Sten Stray-Gundersen, PhD, CSCS, one of the world's leading experts on blood flow restriction (BFR) training and metabolic physiology. With over a decade of research and teaching experience, Dr. Stray-Gundersen has explored how BFR and intermittent hypoxia can improve cardiovascular health, metabolism, and recovery. After earning his doctorate in Exercise Physiology from the University of Texas at Austin, he now serves as an Assistant Professor at the University of South Carolina, where he studies vascular adaptations, cognitive performance, and ergogenic aids. He's also a B Strong master trainer, developing individualized BFR protocols for athletes, military professionals, and everyday people looking to optimize human performance. Together, Dave and Sten uncover how BFR and oxygen cycling unlock powerful adaptations in the body's vascular, metabolic, and hormonal systems. You'll learn how strategic stress signals can trigger nitric oxide production, enhance glucose uptake, improve insulin sensitivity, and supercharge mitochondria for better energy and anti-aging benefits. They also explore how these methods can naturally boost testosterone, growth hormone, and even libido, all while protecting the nervous system and improving recovery. This episode dives deep into biohacking, functional medicine, and smart exercise efficiency, from Zone 2 and REHIT training to nitric oxide signaling, fasting, nootropics, and precision supplementation. Whether your goal is longevity, strength, or sharper cognition, this conversation shows you how to get maximum results with minimal time using the principles of Smarter Not Harder. You'll Learn:• How intermittent hypoxia works at the level of partial pressure and why altitude acclimation upgrades mitochondria and performance• Why hypoxia and muscle contraction increase glucose uptake independent of insulin and improve insulin sensitivity• How blood flow restriction (BFR) accelerates fatigue with light loads to drive hypertrophy, strength, and vascular adaptations• How BFR and hypoxia influence testosterone, growth hormone, nitric oxide, and libido through short, targeted stress• The roles of ENOS, INOS, and NNOS in nitric oxide signaling and what that means for circulation and brain perfusion• Who benefits most from BFR, including athletes, rehab patients, and older adults who cannot lift heavy• Why BFR produces systemic and “proximal” gains, including carryover to glutes and upper body during lower limb training• How to stack BFR with Zone 2, REHIT, and vibration plates for VO2 max, muscle, and time efficiencyDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Sten Stray-Gundersen, blood flow restriction training, B Strong, intermittent hypoxia, mitochondrial function, nitric oxide production, VO2 max, metabolic efficiency, vascular health, testosterone boost, growth hormone release, anti-aging performance, exercise recovery, glucose metabolism, functional medicine, biohacking fitness, REHIT training, Zone 2 optimization, strength and longevity, human performance science Thank you to our sponsors! -KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. -EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. -Leela Quantum Tech | Check out all HEAL360 products and research and get 10% off at https://leelaq.com/DAVE. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • Use code DAVE10 to get a discount on a BFR band today: https://shopify.bstrong.training/products/b-strong-training-system?ref=dave%2F • Dive deeper in Sten's work at: https://bstrong.training/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:25 - Guest Intro 5:40 - Intermittent Hypoxia & Altitude Acclimation 12:11 - Introduction to Blood Flow Restriction (BFR) 22:53 - Systemic Benefits & Who Can Use BFR 30:23 - BFR Effects on Hormones & Libido 40:37 - Nitric Oxide & Vascular Health 48:15 - Zone 2 Training with BFR 54:00 - Advanced Protocols: Stacking BFR 59:15 - Cognitive Enhancement & Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Sara Szal, a Harvard and MIT-trained physician, sits down to unpack why women bear the brunt of autoimmune conditions at rates that keep climbing. She introduces the three-legged stool concept that's required for autoimmune disease to take hold, then breaks down why 95% of her patients show cortisol dysregulation long before they're ever diagnosed with anything. What makes this conversation powerful is that Dr. Szal doesn't just study this academically, she's lived it, going through prophylactic mastectomies and converting her own positive anti-nuclear antibody back to normal through targeted interventions. This is a masterclass in understanding the drift from health to disease and exactly what you can do about it before the soldiers come for you. Learn more about Dr. Sara Szal: https://www.saraszalmd.com/ Buy Sara's books: https://saraszalmd.com/books/ IN THIS EPISODE WE'LL: Discover why your immune system's passport control goes haywire and how sex hormones, mitochondria, and social conditioning create the perfect storm for women to lose tolerance to their own cells Break through the conventional medicine blind spot that only recognizes Addison's or Cushing's while missing the 95% of people whose cortisol patterns are completely dysregulated Transform your understanding of triggers from breast implants to trauma to infections and learn which ones you can actually control (hint: two out of three legs on that stool) Expose the 29% bacterial contamination rate in explant specimens and how biofilms interact with breast tissue to create the downstream inflammatory cascade that mimics classic autoimmune disease Learn the exact protocol Dr. Szal used to convert her positive autoimmune marker to normal, including internal family systems therapy, psychedelic-assisted therapy, and gut healing strategies you can start today CHECK OUT THESE EPISODES: Building a Resilient Gut and Metabolism with Anu Simh: https://www.youtube.com/watch?v=lcLwhow15Qk Mold with Dave Asprey: https://www.youtube.com/watch?v=S4iTfr-kvKo The Shocking Link Between Gut Health & Breast Explant Surgery: https://www.youtube.com/watch?v=hwfnCpB_fQA Links and Resources Let's Connect Podcast: https://podcasts.apple.com/gb/podcast/breast-implant-illness/id1678143554 Spotify: https://open.spotify.com/show/1SPDripbluZKYsC0rwrBdb?si=23ea2cd9f6734667 TikTok: https://www.tiktok.com/@drrobertwhitfield?_t=8oQyjO25X5i&_r=1 IG: https://www.instagram.com/breastimplantillnessexpert/ FB: https://www.facebook.com/DrRobertWhitfield Linkedin: https://www.linkedin.com/in/dr-robert-whitfield-md-50775b10/ X: https://x.com/rob_whitfieldmd Read this article - https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/implant-reconstruction/illness/breast-implant-illness Shop: https://drrobssolutions.com SHARP: https://www.harp.health NVISN Labs - https://nvisnlabs.com/ Get access to Dr. Rob's Favorite Products below: Danger Coffee - Use our link for mold free coffee - https://dangercoffee.com/pages/mold-free-coffee?ref=ztvhyjg JASPR Air Purifier - Use code DRROB for the Jaspr Air Purifier - https://jaspr.co/ Echo Water - Get high quality water with our code DRROB10 - https://echowater.com/ BallancerPro - Use code DRROBVIP for the world's leader in lymphatic drainage technology - https://ballancerpro.com Ultrahuman - Use code WHITFIELD10 for the most accurate wearable - https://www.ultrahuman.com/ring/buy/us/?affiliateCode=drwhitfield

True transformation doesn't come from motivation. It comes from rewiring your mind, reshaping your beliefs, and mastering your perception of reality. This episode reveals how to stop chasing short bursts of inspiration and start creating sustainable change in your thoughts, energy, and biology. You'll learn how belief, emotion, and neuroplasticity shape human performance, longevity, and resilience—and how to reprogram them for lasting results. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with David Bayer, one of the greatest personal growth teachers of our time. His podcast A Changed Mind reaches over 1 million listeners each month, and his event Powerful Living Experience Live was named a top 3 personal development event by Inc. Magazine. His book A Changed Mind has transformed tens of thousands of lives. David blends behavioral psychology, neuroscience, metaphysics, and consciousness theory into practical frameworks that help people rewire their brains and reengineer their reality. He is an entrepreneur, business strategist, keynote speaker, and mentor to some of the world's most influential entrepreneurs and creators. Together, Dave and David explore how motivation is just a microdose of transformation and why true change requires aligning your perception with how reality actually works. They break down the science behind belief, energy, and consciousness, connecting these ideas with biohacking, supplements, functional medicine, and brain optimization. You'll Learn:• Why motivation is only a temporary fuel and how to create lasting transformation• How to test your beliefs against reality and rewire the mind through awareness• The difference between absolute truth and personal truth in consciousness work• Why suffering and challenge are essential for growth and resilience• How to build faith as a biological and psychological muscle• How early trauma programs limiting beliefs and emotional patterns• The four layers of resistance that block personal transformation• Why forgiveness and self-love are essential to dissolving trauma• How perception literally shapes your experience of reality• Practical tools to align your consciousness for high performance and peace Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: David Bayer, A Changed Mind, Powerful Living Experience, belief systems, consciousness theory, neuroscience, behavioral psychology, personal growth, trauma transformation, resilience training, perception shift, motivation vs transformation, emotional regulation, mindset reprogramming, subconscious rewiring, neurohacking, cognitive performance, spiritual psychology, reengineering reality, high-performance mindset, sustainable change Thank you to our sponsors! -GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what's in your air. -Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body's really doing behind the surface. -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -LMNT | Get a free 8-count Sample Pack of LMNT with any drink mix purchase by going to https://drinklmnt.com/DAVE. Resources: • Learn more about David's work: www.davidbayer.com • Order David's book: https://www.amazon.com/Changed-Mind-Beyond-Awareness-Extraordinary/dp/1642939862 • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:25 - Why Motivation Isn't Sustainable 5:14 - Testing Reality as a Hypothesis 9:02 - Absolute Truth vs Personal Truth 11:02 - The Role of Suffering in Growth 15:01 - Building Faith as a Muscle 18:27 - Higher Power & Placebo Effect 20:38 - Believing Without Limits 24:27 - Transforming Childhood Trauma 27:34 - The Four Layers of Resistance 28:58 - Resentment & Forgiveness 33:09 - Turn the Other Cheek 39:28 - Entrepreneurs & Self-Sabotage 43:59 - Building Resilience in Business 46:00 - Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

On today's episode, I'm speaking with biohacker and Bulletproof founder Dave Asprey about the latest in health optimization, longevity, and body hacking. Dave shares his personal journey from building Bulletproof to creating Upgrade Labs, and the science-backed strategies he uses to upgrade his body, brain, and overall performance. We dive into the rise of Ozempic and other metabolic tools, how sleep, light exposure, and circadian rhythms impact testosterone and recovery, and the role of diet, supplements, and peptides in promoting longevity. Dave also explores emotional regulation, stress management, and practical biohacks for boosting energy, improving cognitive function, and living a longer, healthier life. Honest, insightful, and full of actionable advice, this conversation is a must-listen for anyone looking to optimize their health and unlock the power of biohacking. Enjoy!To check out Dave's Website, click HERE.To listen to Dave's Podcast, Human Upgrade, click HERE.To connect with Dave on Instagram, click HERE.To read Dave's new book, Heavily Meditated, click HERE.To connect with Siff on Instagram, click HERE.To connect with Siff on Tiktok, click HERE.To learn more about Arrae, click HERE. To check out Siff's LTK, click HERE.To check out Siff's Amazon StoreFront, click HERE. This episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct, or indirect financial interest in products, or services referred to in this episode.Go to curology.com/dreambigger to get your first bottle of DayPrime for FREE when you subscribe, all you need to pay is $5.45 shipping and handling.Go to quince.com/dreambigger for free shipping on your order and 365-day returns. Go to getcanopy.co to save $25 on your Canopy Humidifier purchase today with Canopy's filter subscription. And look for other Canopy products such as the Canopy Bath and Shower Filter. Even better, use code DREAMBIGGER at checkout to save an additional 10% off your Canopy purchase. Your skin will thank you!Book an appointment today at bit.ly/asktia-dream shopify.com/dreambiggerThousands have already trusted Rula to support them on their journey toward improved mental health and overall well-being. Head on over to Rula.com/dreambigger to get started today. After you sign up they ask you where you heard about them. PLEASE support our show and tell them our show sent you. Go to Rula.com/dreambigger and take the first step towards better mental health today. You deserve quality care from someone who cares.Produced by Dear MediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this illuminating conversation of Be It Till You See It, aesthetic nurse and biohacker Rachel Varga joins Lesley Logan to discuss how to achieve lasting radiance by aligning health, mindset, and beauty. She shares how lowering inflammation, managing stress, and purifying your environment can help you look and feel your best—proving that confidence and feeling at peace are the real anti-aging secrets.If you have any questions about this episode or want to get some of the resources we mentioned, head over to LesleyLogan.co/podcast https://lesleylogan.co/podcast/. If you have any comments or questions about the Be It pod shoot us a message at beit@lesleylogan.co mailto:beit@lesleylogan.co. And as always, if you're enjoying the show please share it with someone who you think would enjoy it as well. It is your continued support that will help us continue to help others. Thank you so much! Never miss another show by subscribing at LesleyLogan.co/subscribe https://lesleylogan.co/podcast/#follow-subscribe-free.In this episode you will learn about:How Rachel's nursing career evolved into a holistic approach to beauty and biohacking.The science behind lowering inflammation to boost vitality and radiance.Why redefining vanity as self-respect empowers confidence and self-care.Everyday habits that support graceful aging through stress management and sleep.How cultivating peace and integrity supports inner and outer radiance.Episode References/Links:The School of Radiance Website - theschoolofradiance.comPromo Code: LesleyLogan15 for 15% off one-on-one sessions, tutorial, and membershipSchool of Radiance Podcast - https://www.theschoolofradiance.com/podcastsInstagram: @RachelVargaOfficial - https://www.instagram.com/rachelvargaofficialGuest Bio:Rachel Varga, BSN, RN, CANS, is a Double Board Certified Aesthetic Nurse Specialist. Since 2011, Rachel has been offering medical aesthetic rejuvenation in the specialty of Oculoplastics and is known for providing a natural and healthy-looking transformation and educating through her show "The School of Radiance" podcast. She has performed over 20,000 rejuvenation procedures and is also a trainer for other practitioners on rejuvenation procedures including medical grade skin care, laser skin rejuvenation, injectables including neuromodulators and dermal fillers, and slowing aging in general. Rachel is passionate about delivering the highest standard of care, with a focus on what the patient's specific rejuvenation goals are, and a tailored approach to suit their needs, values, and lifestyle. She has published multiple research articles on rejuvenation protocols for the eyelids, jawline, and overall skin health transformation. Rachel is known for her gentle touch, natural-looking results, and making her patients feel comfortable, and at ease with her caring bedside manner that originated in pediatric nursing before beginning her career in medical aesthetics in 2011. She will guide you in creating your customized rejuvenation plan and skincare routine to achieve your goals through one-on-one sessions, expert 7-week seasonal skincare tutorials, and year-long membership for the deeper layers of being beautifully radiant at TheSchoolofRadiance.com. Rachel Varga is one of the first to blend Western approaches to skin care and rejuvenation, functional insights, and biohacking optimization strategies. By blending the best of these worlds and observing what her most radiant patients are doing she will also help guide you on your path to healthy skin and vibrancy for many years… If you enjoyed this episode, make sure and give us a five star rating and leave us a review on iTunes, Podcast Addict, Podchaser or Castbox. https://lovethepodcast.com/BITYSIDEALS! DEALS! DEALS! DEALS! https://onlinepilatesclasses.com/memberships/perks/#equipmentCheck out all our Preferred Vendors & Special Deals from Clair Sparrow, Sensate, Lyfefuel BeeKeeper's Naturals, Sauna Space, HigherDose, AG1 and ToeSox https://onlinepilatesclasses.com/memberships/perks/#equipmentBe in the know with all the workshops at OPC https://workshops.onlinepilatesclasses.com/lp-workshop-waitlistBe It Till You See It Podcast Survey https://pod.lesleylogan.co/be-it-podcasts-surveyBe a part of Lesley's Pilates Mentorship https://lesleylogan.co/elevate/FREE Ditching Busy Webinar https://ditchingbusy.com/Resources:Watch the Be It Till You See It podcast on YouTube! https://www.youtube.com/channel/UCq08HES7xLMvVa3Fy5DR8-gLesley Logan website https://lesleylogan.co/Be It Till You See It Podcast https://lesleylogan.co/podcast/Online Pilates Classes by Lesley Logan https://onlinepilatesclasses.com/Online Pilates Classes by Lesley Logan on YouTube https://www.youtube.com/channel/UCjogqXLnfyhS5VlU4rdzlnQProfitable Pilates https://profitablepilates.com/about/Follow Us on Social Media:Instagram https://www.instagram.com/lesley.logan/The Be It Till You See It Podcast YouTube channel https://www.youtube.com/channel/UCq08HES7xLMvVa3Fy5DR8-gFacebook https://www.facebook.com/llogan.pilatesLinkedIn https://www.linkedin.com/in/lesley-logan/The OPC YouTube Channel https://www.youtube.com/@OnlinePilatesClasses Episode Transcript:Rachel Varga 0:00  I take this approach of longer lasting beauty through biohacking, because when we reduce inflammation and toxins on all fronts, we then set our body up for success, for being our most radiant versions. And the more radiant we are, the more high vibe we are, the more we can get what we desire out of life, in both our personal and professional lives, and be great people, because our bodies are operating properly.Lesley Logan 0:32  Welcome to the Be It Till You See It podcast where we talk about taking messy action, knowing that perfect is boring. I'm Lesley Logan, Pilates instructor and fitness business coach. I've trained thousands of people around the world and the number one thing I see stopping people from achieving anything is self-doubt. My friends, action brings clarity and it's the antidote to fear. Each week, my guest will bring bold, executable, intrinsic and targeted steps that you can use to put yourself first and Be It Till You See It. It's a practice, not a perfect. Let's get started. Lesley Logan 1:11  Hi, Be It babe. Okay, this is gonna be a really fun conversation. I wanted to have this conversation for a while, and it's really like, I'm intrigued by all this, right? I want to, I want to actually look and feel good for as long as possible, but not in like, a crazy, like, change how I look dramatic way, but like, as in a no, this is like, I want to look like me. And so when I met our guest today, because I was on her amazing podcast, Rachel Varga, she's the host of the School of Radiance, and I was like, oh, I vibe with this person. I really like what they're saying. It's intelligent. It's from a place of research and science and methodologies, and she is so knowledgeable about biohacking and things we can do when it comes to med spas and what we're doing with to support ourselves and how we feel and how we look, and then we go on a wide range of topics. We don't hit everything I want to talk about, so I'm going to have to do this again. But I really think you're going to, one, learn a ton and have a lot of permission get granted, because maybe it's not something you have to do to you, maybe it's something you would get to do around you, or maybe it's about changing something in your environment, right? So now I'm going to let Rachel Varga give you all of her amazing wisdom. Lesley Logan 2:26  All right, Be It babe, this conversation is one I've been really wanting to have, but it had to be with a special person, and so I've been waiting the 500 plus episodes to find the person who we can have a conversation about radiance and how we how our how we can age the way we want to, and look good doing it without feeling like we're being vain or going too far. And so Rachel Varga is our guest today. Rachel, can you tell, can you tell everyone who you are and what you rock at? Rachel Varga 2:51  Yes, Lesley, so great to be here, and we had a fantastic interview on my show recently, the School of Radiance podcast. And, so technically, I'm a nurse, and I've been an esthetics nurse since 2011 so I've been in the game for the rejuvenation side of things for a while. Been in that game, published research papers. You can look my name up on PubMed, Rachel Varga, you'll see my eye rejuvenation papers, jawline rejuvenation papers. And then I also teach other doctors and nurses internationally how to do rejuvenation from the non surgical side of things that like injectables. And I know we're going to talk a little bit about that, what we can do that's cleaner options, what's actually going to work and give us the results that we desire. And so I love to teach, and I love to talk about what we can actually do at home. So on this podcast, we'll talk about the lifestyle side of things, and kind of delineate what we can do at home and then what's available in the clinic. But I take this approach of longer lasting beauty through biohacking, because when we reduce inflammation and toxins on all fronts, we then set our body up for success, for being our most radiant versions. And the more radiant we are, the more high vibe we are, the more we can get what we desire out of life, in both our personal and professional lives, and be great people, because our bodies are operating properly.Lesley Logan 4:23  I love this because I love that you can they it's almost like a there's a few different prongs. So if you're someone who's like, I don't want to do surgery, I don't want to do the injectables like people start to look like cat ladies at some point. And I'm sure that's not all injectables do that. I'm sure there's a point which one could stop. But the idea that we there's things we could do at home, it sounds why wouldn't you, like, Why? Why wouldn't you want to do something at home? So before we get into that, though, I do want to kind of know, like, did you always want to get into esthetics? Was this something that you could wear, like, interested as a kid? Like, were you doing makeup? Like, how? Like, what was the journey that got you here?Rachel Varga 4:59  Yeah. Okay, well, practically speaking, my mom's an RN, and I saw how hard she worked, but I also saw that it was a great job. It's a great way to be in that nurturing, supportive, healthy role in the family. It's like something happens to the kiddos, like you know what's going on, or your partner or yourself. It's just great knowledge to have from a nursing perspective for yourself and those you love. My father's are carpenter and so I always had this eye for, oh, that bumper is a little not so straight, or that picture is a little canted. So I had this eye for symmetry and proportions from that, and then also the health side of things. But I saw my mother really struggle as a night nurse. And she did night nursing, so shift work, it's just brutal in extended care for her pretty well entire career, she got breast cancer. She was, at one point, weighed 220 pounds. So she was the type of woman, great woman over gave, did the shift work. So I learned early in my career that I didn't want to be that kind of nurse. And did Pediatric Nursing, pediatric ICU care for a couple years. And during that time in my nursing education, I'd had a few rejuvenation procedures myself too, both surgically and non surgically, and to myself, the aftercare information like the pre post care wasn't great, and for me, going through nursing training, I was obviously watching all the vlogs online. There aren't really a lot of professionals actually talking about this stuff, and I think it's kind of interesting, and people want to know how to get the most out of what they're investing in in the clinic, and, of course, at home, and how to recover before and after non surgical or non surgical rejuvenation options. And thought I wanted to be a doctor. So did all the med school prerequisites, chem, Organic Chem, biochem. And while I was doing prerequisites and applying to med school, which I did for one year, I got a job as an esthetics nurse, did my injectable training, started in ocular plastics in 2011 and just loved the field. I loved the pace. The hours were great, and I would get access to anything and everything. Then something happened. I met my good friend Dave Asprey. Actually helped get his face ready for superhuman so when you look at that book cover, that's my work. Oh, what's this biohacking stuff? This is pretty cool. Started to do some of it myself, cold plunging, intermittent fasting, more protein, adding antioxidants, amino acids, all sorts of great stuff that's in the biohacking world, red light therapy. And then I was in two car crashes. I had to really lean into the biohacking and recovery side of things and supplementation so that I wasn't hurting all the time, and so that I would recover faster. And partner has been a pro athlete as well, so very in tune with the athletic recovery side of things too. Then something interesting happened. The better I cared for myself from an inflammation perspective, I didn't need as much rejuvenation. Scars were fading after just a couple of days post breakout, instead of for months, and I'd have to laser that redness away. I didn't need to do neuromodulators every three months, I would actually go anywhere from like, a year to a year and a half in between.Lesley Logan 8:45  For the people who are like, what's a neuromodulator,Rachel Varga 8:49  The brand names that you probably know about are Botox, Xeomin, Dysport, Nuceiva, Jeuveau. There's always new ones growing up. So the technical term for those is neuromodulators. And then I also started to notice, oh, wow, I'm not burning in the sun in 10 minutes anymore. These deoxidants, this reducing inflammation, is actually allowing me to go outside and enjoy my life more. And I as a researcher, put together a paper for the biohacking community a couple years ago. What are some of the biohacks that actually can support slowing aging in sort of like a methodical framework, kind of way, because there's so many bright, shiny objects in the in the biohacking and wellness space, like, what actually should we start with?Lesley Logan 9:42  This is insane. So this journey that you went on, like, first of all, you met the person. Like, yeah, you were like, you just met them. And then you needed what they had. Like, thank goodness you met them, because you put, who knows how long would have taken you to stumble upon biohacking in that way. And then it got you to see how it worked on the things that you already do. I can it's interesting to me because, like, I think some people in your field would be like, what is the need for me if I could just biohack my way to blemish-free skin that can be out in the sun, you know what I mean. But obviously, like, there's, there's kind of a place for everything. You know, there's also like, what works for you and what helps with what you need. And so I love the idea for those at home who are like, well, what are some like, what are like? Maybe they could Google what an antioxidant is. But like, what are some things that they should be thinking about when it comes to inflammation and things that can affect how they look? Because I think sometimes people go, Oh, I'm just older. And we were taught like, Oh, you're 40, so now you're 50. Like, these things happen. But from what I understand in biohacking, you can actually do a whole lot. It's not about the age, it's kind of about what you're eating and what you're doing.Rachel Varga 10:54  Yeah, you could actually test instead of guess what your biological age is. And I do this usually about once a year, and my biological age, last time I tested it was nine years younger than my chronological age. So doing something right. Lesley Logan 11:11  I love that. Rachel Varga 11:14  When I started to speak on the anti aging, the functional, integrative and wellness sides of things, being an aesthetic nurse, like a traditionally trained nurse, and then in the specialty of aesthetic medicine, I was kind of the odd one out, a little bit misunderstood, especially in the rare community that I'm in, people didn't really get it. It's more like a California and Florida kind of thing, where people in there, in those states in particular, really big into anti aging medicine, and so that was a bit tough for me. But you know what, some of us were just pioneers in the space. And Dave is more of a disruptor, and I'm more of like an encourager. If I can do it, you can do it too. Lesley Logan 11:59  Yeah. And I think, like, you know, the I, what a great place where you can go, okay, here are your options. We can do these things, and here's how often you'd have to do them, and we can absolutely do them, or we can do this thing, and then this is how often, or you could also do this at home. And then it would make whatever we're doing here would support that, or it would reduce your need for that, is that what I'm hearing, like, the biohacking, like, really supports what you do?Rachel Varga 12:26  Bingo. So for me to speak on things, because I am a traditionally trained RN, I have to be able to speak on things that are published in the literature. There wasn't really anything, and I knew this worked. I would see it in my before and after photos. See, you know, 70 to 90 year olds looking fantastic, and they barely need anything. They were aging better. So the jawline paper that I wrote, I basically put in that paper an algorithm for rejuvenation, starting with skin care, then getting into maybe at home peels and at home dermarolling, doing some in-clinic lasers for reds, browns and collagen, you know, resurfacing pore size, polishing the skin, and then the non surgical injectables. So say you guys all probably hear the word Botox, so neuromodulators and fillers and then surgery. So to start from a space of least invasive, you know, do some things, see if you're happy with those results, you might not need the surgery, but surgery definitely does have a place, coming from ocular plastic surgery for the eyelids. And so I wrote a paper on that, basically an algorithm do least invasive to most invasive, and then the Oxidative Stress Status and Its Impacts on Skin Aging paper that was more like a framework of what's the lifestyle stuff that we can do to actually clean up and purify our environment by purifying our air, water, lighting, electromagnetics, testing, instead of guessing the foods that we're eating and then getting into detoxing. And when you do all those things, you should actually be able to get better results from your treatments. And if you go on message boards for people that have issues after injectables or lasers, chances are there was a degree of autoimmune conditions running in the background, or their toxic bucket was really full. They had rejuvenation bucket tipped over, and they had a manifestation of some underlying things that were happening. And then also, during the process of writing those papers, I came across some data. This is why it's not a nice to do. It's a need to do, to look after yourself, that autoimmune conditions, or, more precisely, deaths of unknown causes, which I reached back to the source of you know, what does this category actually mean, autoimmune condition or someone passing away before diagnosis, it actually doubled in 2019 compared to the data six years earlier in Canada, this is Canadian information, and then it doubled again in 2021. So autoimmune stuff for skin is like, eczema, psoriasis, those are typically the skin stuff that we see. Lesley Logan 15:25  It's interesting that you brought that up because it is like, I think people are like, there's so many people with autoimmune it's like, well, now that we know what to test for. The thing about tests, that's the thing, when we it was all, there, it has probably been there for a really long time. The doubling in such a short period of time is scary, but also it, you know, if the tests weren't right arranging or the doctors don't know to test for these things. But I love that you brought that. I like how you bring that up. It's like if you had stuff run in the background, if you were already inflamed, and then you do something that can add to that, like, it is just like the needle that broke the haystack. And so then the things get the blame when it's a whole host of things that are going on. And so I think this is really cool. You know it's and I don't want to be ignorant, so I think it's really, to me, what I find interesting is that, like, I would never have associated a biohacker with someone who would also be doing any of these treatments. Like I would, you know what I mean? Like, I think people think you're either nothing goes in your body except for these things, or you're, like, whatever, It's a free rein, I can do whatever I want. And so to find someone who sits in the middle, I actually think it gives people a lot more permission. And I actually one of the things I want to talk with you about is, like, just permission, like, I think a lot of people feel bad or feel embarrassed or feel like they shouldn't talk about that they want to make any changes to how they look, because we do live in a place now where, thankfully, people are more accepting and people have been taught to not hate their bodies like we should love our bodies. In fact, your body is listening to you. So part of biohacking would actually be to not talk about the things you don't like about your body because your body's listening. But how can we think about like is it vain for us to want to want to change things on our face, or to want to look a little younger, to want to look a little fresher? Is that? Is that a bad thing? Like, should we not be wanting to change these things? We just be happy with how we look?Rachel Varga 17:11  I think that there's a similarity here with this concept of imposter syndrome. Everyone who starts to do something new is like, Oh my gosh. I don't know of like, Can I do this? Am I gonna get laughed at? I think it's that's just as common as the shadow side of beauty, which is, is this vain? Am I doing something that's selfish to care for myself? One of the reframes that I love to talk about is self-care, self-love. I get so many sweet downloads when I'm doing my skincare, I'm blow drying my hair, I'm doing my beautification, my makeup, putting on a cute outfit, looking at myself in the mirror, it's like, Oh, wow. I had three hours of sleep last night. How the heck do I look this good? Well, there's some biohacks that I did to hack a bad sleep and why I had a bad sleep, which is hilarious. So we can definitely talk about that. But the vanity component is essentially the shadow side of beauty and radiance at its core. So I love to investigate the psychological, the energetic things behind everything as well, because everything is energy. And we're seeing a shift now, though. In about 2018, a number of my clients started to ask me, Rachel, what can I do for healthier skin I want to improve my skin health. So I really started to notice the shift. And then now fast forward to the year that we are in now, every med spa, well, the ones that are, you know, up with the current times, are doing things like NAD infusions, they're offering weight loss, they're offering hormone support, and all of these different things that we're now seeing a really exciting time in the med spa industry, the functional space, integrative and biohacking space, coming together. It's almost like this bifurcation point a couple years ago, but I did see the writings on the wall back in about 2018 that this was going to happen, and now this is what the most notable med spas in the world are doing, is they're incorporating all these things because people want to go to a one-stop shop and not necessarily just look at rejuvenation as being vain, but a form of self-care. They're doing other things as well that they're investing time and energy in, or they might have a health spending account that makes them feel better, because when you feel better, you look better, and when you look better, you feel better. So what I like to suggest, if someone is really grappling with, okay, money's tight or I feel vain about doing this, feel like that money should go to my kids or whatever. But if something's bothering you for a while, say, for example, lines between the brows, or lines to the forehead, or hooded upper eyelids, lower eye bags, melasma, pigmentation, red acne scars, large pores, acne scarring, losing sharpness to the jaw, lines, jowls, fullness to the neck, the list goes on. But if something is really bothering you and you're looking at yourself in the mirror, be like, I really love to do something about that, because it's the one thing that kind of bugs me. I think that the benefit of knowing that, hey, there are some really great health non surgical, or surgical things that we can do to actually support those things. But my angle is, okay, what's the least toxic thing that we can do to give the best results? What is going to give the most long term benefits? So that's why sometimes surgery, like eyelid surgery, is one of the most common surgeries performed to remove excess eyelid tissue. That's actually probably even going to cost less money than trying to do all these other non surgical things, and you have a longer result. So it just depends on everybody's situation. But the vanity thing is something I think every single person grapples with, if they're completely honest with themselves, and then they do it. They do their rejuvenation, they bump up their at home skincare routine, they purify their environment, like, Oh, I feel better. I'm gonna keep doing this, because it's something I do for myself, kind of like getting your (inaudible) you always feel so much better after you have, you know, fresh highlights or whatever. Lesley Logan 21:36  Yeah, yeah. Well, I think, like, there's a difference between doing something because you think it's going to get you people's reaction from people, and doing something for yourself. You know, I think if you are do making changes to yourself, because for other people, that would be a problem, but if you're doing it for yourself, like you said, you don't like the way your pores are. I have my mom, she has talked about the eyelid surgery, and I saw her recently in person. I was like, Oh, poor thing. I don't know. Can you see? Get like, you know, like, and that's not a vain thing. It's also like a necessity, necessity thing, but also like in being it till you see it, some of these things are taking up so much brain space that they're holding us back from coming out and showing people who we are like, if you're not putting yourself out there because you have a scar or you have you don't like the way something looks, that that does bother me, because it does mean that the world is missing out on what your gift is. You know, there are people that you're the only person who can do what you do, and if you're hiding yourself for whatever reason, then that is a bummer, because those people miss out on it and they end up getting swindled by somebody else. So I, I'm of the place, like, if it's for you and it's going to help you show up as the best version of yourself, like, you know, you really do have to look, look into that. But I also love your approach of, like, what's the least invasive, least toxic, most long lasting. And I think if we, I think if we go with that approach, as opposed to quick fixes, then we all, and that goes for everything, not just even for the things you do with your face.Rachel Varga 23:11  100% Oh, you touched on so many beautiful things. So we're gonna back this, because there's some nuggets here for everybody. What happens when you go into the wild, you know, if you're, if you're anything like me, you're working from home, you're going to the gym, you're going to the grocery store, going to church, you know, some work in social events, but that's kind of what the lifestyle looks like. But when we and sometimes I want speeches, and that's super fun, I get all glammed up when you go out into the wild and you see two kinds of people, you see the one person that I just have my hair and, like, a cute little dancer's button I got my workout outfit on. You would love it. It's, like, very Pilates appropriate. Lesley Logan 23:56  I saw it when you (inaudible) I was like, that's so cute. I need a little shawl for my my one my jumpsuit.Rachel Varga 24:02  Oh and I love my body, and I work hard. I lift weights, work on the flexibility, stability, cardio, strength, all those things. I feel fantastic because it brings me in my body as well. W e're very grounding at the end of the day, when you see that individual that they got a little bit of makeup on, they brush their hair, they don something cute, even if it's a little bun, and they have a smile, and they're bright, and they're connecting. Compared to the other person that's just schlepping it. They got their PJ pants on or their sweat pants, they're not put together at all, and they just look like they legitimately rolled out of bed. It's like, okay, something's going on with that person. Oh, this person's really showing up for themselves. They're, you know, putting effort into their appearance. What that actually communicates when you show the world that you're valuable because you value yourself, that's powerful. And if you're showing the world that you just rolled out of bed, your life's a mess, people aren't actually going to value you in the same way. I know that sounds really brutal, but you will be more valued in your relationships. In the professional space, you'll have better relationships. You'll probably be able to make more money, because there's also research to show that people actually who care for themselves the way that they look, earn higher income. But the cool part here that you touched on for you know, reactions for other people is it for yourself. I've seen that where ladies have come to me and their boyfriends in the waiting room and they say, I want to get my lips done. And their lips are already like fantasy lips, if you know what I mean. And I just say to them, no, that's gonna go. If I do anymore, it's gonna really put your lips out of the ideal ratios that actually creates beautiful lips. So you're not a candidate for this treatment. Obviously, there's some body dysmorphia that can have too. However, when we do rejuvenation in a way that looks natural, feels good for us. You know, the body's just like, yes, I want to do this. But thinking about it for a while, it helps to build confidence. Something very interesting about confidence, actually, is that the more confident we are, the better able we're going to be in showing up and building our community. And community is a deep survival need. We're not meant to go through life on our own. We're not meant to over give. We're meant to be supported and receive from those around us, and obviously have it be reciprocated. But the there's the value component, there's the confidence component, there's the community component as well. So there's a lot of really beautiful things actually, about beauty and what it does to our lives.Lesley Logan 27:00  Yeah, and I do, I find it's like, so I used to work at a studio when I lived in L.A., I'd have to, like, leave the house and obviously, how I run and how I shop at the gym, different things, but anything before 7 a.m. that's what different. But when I would go to my studio, I would get dressed to work, go to work, I would teach the whole thing. When I started working from home, I noticed like, oh, I'm not in front of the camera today, so I would just kind of like, still be in the same clothes I did my walk and my workout in, and I was like, starting to slowly feel down about myself and having to give myself more pep talks. And I was doing my fake eyelashes, and they kept getting bigger and wrong, and I kept giving them feedback. And I was like, I don't really like how this is looking. So then I got rid of the fake eyelashes, and now I'm like, well, now I'm a bald eagle, and now I think I'm over at and and I was like, hold on. I also could learn how to do makeup for my natural lashes, and I could get dressed each day, like, how would if I got dressed each day? And what I realized is, by using the clothes in my closet and getting dressed and having a routine of putting my makeup on and and things like that. All those things actually made me feel better. So that whole little haze that, like cloud that was kind of like following around, kind of like an oppression commercial. I don't know if you havethem in Canada, but we have them here, where they're, like, trying to sell you like this cloud that just like hovers over this girl as she walks around, the cloud's gone. I was like, oh, over time, I slowly became used to not doing these things that felt like a waste of time or like not a big deal who's seeing me, and the more I actually spent time with myself. It's not to go back to the vanity topic, It's not vain. It actually just made it easier for me to show up as myself and put myself out there. Because I wasn't going, Oh God, my hair is a mess. Like, like, I, like, got ready for the day, just like, as if I went out into the world to go to work. And so I would say, like, it's really easy for us to go, oh, the world expects us to look a certain way. And really, I actually think the world is quite obsessed with people who are confidently walking in front of them, people who are confidently walking in a room like it. Actually, I'm always amazed, like the people who are famous or infamous and things like that, like some of them, I would never consider like a natural form of beauty, but people are excited about them because they're so calm they walk in, they have their head held high. And so I think if we just go back to like, what are you doing for yourself to help you show up to be the person you want to be, like, those things can't be wrong.Rachel Varga 29:25  Very well said, the, I love this show so much. I love connecting with you, Lesley, I think you're fantastic. You're hitting the nail on the head of, like, really deep topics around beauty and rejuvenation and not enough people are kind of talking about this stuff, the concept of feeling down and self-talk. Let's break that down for a second. A lot of us say, Oh, my fine lines and wrinkles, or, you know, my elevens, or my acne scars, or from an injury perspective, because a lot of you listening are ahletic and sometimes injuries can happen when you're doing new things and pushing your limits and building your strength and your resilience and your readiness and adaptability and all those good things. So instead of saying my whiplash, I detach from it, and I don't say my I say, oh, you know, I'm experiencing this or, Oh, I have a blemish, but I'm not reinforcing it into my identity, because a lot of people have these things that they reinforce into their identity, and then it's like, stuck in their field, if you will. Now we're gonna go just a little bit woo.Lesley Logan 30:39  Oh, you know, we used to only be a one woo show, and considering where the world is right now, Brad and I have gone two woos. We're woo woo in it.Rachel Varga 30:50  Yeah, very much grounded in the 3d science, I published papers. I just the other day, was teaching 60 doctors in Vancouver. Super fun. I just can't help but notice this group of patients that I observed in my career. This is why I talk about radiance, men and women aged 60 to 90 that had never done any rejuvenation. They would come to see me, either on a video call like this, or in the clinic, and I would look at them and be like, Wow, you look fantastic. Like, yeah, you know a couple of things like, bother me. I'd love to do something about it, but it was just how they carried themselves. So I started to kind of unpack this. What is this? What is this that I'm noticing it's like this inner glow, this inner vibration, and what are the components in their life that are contributing to that, which you can ground to the key determinants of health, which are recognized globally as being important factors to determining how healthy you're probably going to be depending on the environment around you. They had a certain vibe to them. Their skin shown differently. Their voice was different. They were very present. They had a family life, they had a spiritual practice. They had hobbies, they had a community. So I coined this radiance, and then I started to dive into some Ayurvedic texts, and came across the definition of radiance, which I think is one of the best definitions of that word that I've ever come across. It's the electromagnetic projection of all of your body systems. The radiant body is the 10th body, and then we have our body, mind, spirit, energy. There's some other bodies in there, but the radiant body is basically that electromagnetic projection of you and a reflection of how all your operating systems are running into the world. And when you begin to hone and cultivate this radiant energy, it's kind of like you become a queen, and you enter a room and everybody notices you for all the right reasons, you become a magnet. And with that, when you step into that very powerful, radiant, queen, feminine and (inaudible) energy, you also repel vibes of certain people that aren't going to be in your highest it's like you're a magnet, but you're also very attractive.Lesley Logan 33:22  Yeah, just like magnets also repel the other side. Rachel Varga 33:25  Exactly. Yes. So magnetic to the right people, the right situations, the right opportunities, and telling yourself (inaudible) oh, you know, there's great things coming just around the corner that are better than I even imagined. And I say that all the time, and it happens all the time. So this becomes you. You become like this force. And one of the most cool things about this as a woman is you get respected, and you are revered by men, not just idolized for looking a certain way, but actually respected and revered, and this is getting into some of the more powerful layers of beauty and radiance. And what you mentioned with your self talk, you probably felt some guilt and shame, right? And those are the lowest vibrations we can possibly sit in. The highest ones are peace love, joy, then there's pre enlightenment, then there's enlightenment. So peace, love, joy, channel your inner (inaudible) that is actually setting the stage for all of your cells and inner machinery and operating systems and field, the human biofield, is an emerging body of science to shine brighter, to slow aging, to feel better, to look better.Lesley Logan 34:47  I love this, and I really do believe in it, because there was years ago I listened to a podcast where they said your cells are listening to you, and how you talk about yourself is what you produce. So if you, going back to your like, my scars, my this, it's so important that you do, you don't hold on to those things, because the body is listening and like they actually did some scientific studies, multiple ones. One of them was they took these people, they blindfolded them, they set them in a chair. They were in a room where they could hear a fire burning, right? And they could hear this hot and they could hear like this, when you put, like, water goes right, that whole thing. And they're like, okay, we're gonna take this (inaudible) and we're gonna brand you, right? And these people are like, Oh my God, they're telling, they're describing what the branding mark is going to be. All these things. I don't even know how they clear this, because it sounds like trauma and torture and all the things, however they did it. And what they would do is they would like make the sound, and then they touch the person with a pen, a pen, and the person develop the welt in the shape of the description of what the branding was going to be. Right? Like, now, whether it lasts or not, wasn't part of the thing, but like they the body was like, so prepared for what it was told it was going to become. And another doctor was trying to figure out if it was a scraping of the knee or the drain of the knee that actually was healing these knee issues. So of course, he has to take three groups of people, one where nothing happens, one where they scrape and one where they drain, and then compare the three and the people who had nothing they were just put into they were put under anesthesia. They played, they played a video of a knee surgery happening so that they would hear in their subconscious they were sent to do all the same post surgical protocol as everyone else. They had the same results as the people who had had surgery, because they told themselves, I had surgery, my knee is fixed, and their body did these things. And so I became so conscious of like, what are we actually talking to ourselves about? Because before we go into all the things we could do to change our bodies, before we go into the biohacking foods, and then what type of treatments we could do, how you're talking to yourself, is literally free. It's a, it's a, it's a free thing you can change. It costs nothing.Rachel Varga 37:01  when you think of a monk, what are they doing all the time? Lesley Logan 37:03  Oh, we get to see them in Cambodia all the time. They are meditating and they're praying. They give blessings. That's what they're doing, just sitting there meditating.Rachel Varga 37:15  And you said something very profound, giving. Lesley Logan 37:19  Blessings. Rachel Varga 37:23  Who you are, depending on what really your reason is for being here. For mine, it's really to activate and initiate men and women around me to be their best versions. I'm very clear on that. So for me and my presence, that's how I serve. That's how I offer. It's how can we be in this state where we engage with others and we brighten their day, we say something kind to them, the way that we move through life is like an offering and a blessing. We first need to fill our cup first, though, that's very important. One of the things that you can channel next time you're in your Pilates or a heavy lifting situation, I do this all the time at the gym. I actually do breath work because for activity as women, especially if you're around that pre perimenopausal, perimenopausal, menopausal and postmenopausal, the body's going through transmissions, and what breaks down collagen and elastin quickly is elevated cortisol, which results in a drop of estrogen. When estrogen falls, collagen, elastin, fall too the more at peace you are, the more in that parasympathetic state you are, the less you're in the sympathetic state with high cortisol, adrenaline, you're going to age slower. You're going to have a slowness of the collagen elastic breakdown. And you could actually just do things to stimulate it, right? Like good skincare, sunscreen on the high real estate areas, mineral only at home, dermarolling, in clinic, lasers to get that collagen back up. Consuming collagen is also great. 10 to 12 grams a day is what's in the literature to actually create those visible skin changes in a month. But what I do when I work out is something hilarious, and I actually did bench press with the bodybuilder gym (inaudible) crew at the gym. I was included. They respect me. They revere me. They see my dedication and hard work. So, you know, I was right there with them get it spotted and encouraged, and here I am elevating their presence as well. But when I work out, and I was actually sharing this with one of the bodybuilders, because they'll do like smelling salts to get them in the sympathetic state, which could be good for the masculine, but for the feminine, we don't want that. We want to keep that cortisol down, what I do, actually, between sets of working out, is go right into parasympathetic breathing. Breathe in for four seconds, hold it for four seconds, exhale for four seconds. And you can do this, do like four to five cycles of that. You can drop into that at any point during the day when you get some news of a task that you need to do. I run like 13 businesses. So there's always, you know, these kind of small fires, and I have to figure out, like, who to delegate what I need to do, blah, blah, blah. But there's always something. So no matter what, I just always drop into that. Have those dates, have that honey, so I have that glycogen. Take those adaptogens to support the adrenals. Do the self care. But the biggest thing, I think, for beauty and slowing aging is, what do you think creates peace?Lesley Logan 41:05  What do I think creates peace? In someone's life?Rachel Varga 41:07  Yeah, what do you think creates peace in someone's life? Lesley Logan 41:10  Oh, my gosh. Well, I don't, to be honest, my mind is (inaudible) a few places. One, good sleep, that helps with peace. Two, not taking things personally, that could take, I think that could cover a lot of things. Maybe the whole four agreements would create peace and then self love.Rachel Varga 41:29  That's beautiful. What actually builds our confidence when you make a decision and we're happy with those decisions that we're making, or making them out of integrity. People who make really bad decisions, they have to live with guilt and shame, and they have terrible sleep. They're tossing and turning, and they got night sweats. All sorts of stuff goes on in someone's nervous system when they constantly have that guilt and shame, operating in the background. Ask for forgiveness, but move towards operating in integrity in every single thing that you do, you will have more peace because you're making better decisions. I wouldn't I can't picture a monk acting out of integrity, right? That's like against their code. So to have that, I just think it's gorgeous. Not taking things personally is also great. So you're recognizing that not everybody is taking as good care of you. You might have different values or lifestyles or what's important to you. So not taking things personally and just kind of witnessing that everyone's on their own journey, and just let go, but just have that knowing that the decisions you're making are out of integrity, and self love is such a beautiful component to that as well because you're telling your body when you're doing your skincare in the am and pm, you're washing your face, you're putting great things on that aren't toxic, and you're doing a lot of the personal development stuff as well, to be the best human that you can be, to be the best woman partner that success in your career, and just be a light in the world and think that and bring beauty. Literally, I've done this. I've just had a terrible day, something's going on, and I put on a cute outfit, do my hair and makeup, and I go engage with someone. They're like, Wow, you look so pretty today. It was like, it brightens my day. My beauty brightened their day. And then send and receive. I give them a compliment of something that I see is beautiful in them, too.Lesley Logan 43:35  Yeah, oh my gosh. You know, so many good things. And there was like five, five other things I wanted to get to in today's episodes. We're just gonna have to have you back. We're just gonna have to have you back because I was like, really hoping we could talk about, like, is Gua Sha really working? What are the things I should be doing? So we're just gonna have to do this again, and we're gonna take a brief break and find out how people can find you, follow you, work with you. And you already gave us some good stuff, but some Be It Action Items. Lesley Logan 43:58  All right, Rachel, where do they hang out? Where do you hang out? Where can people like stalk you in the best way, get more information, work with you, talk with you, where can we send them?Rachel Varga 44:08  Absolutely, I hang out on Instagram. I love to engage with those who are you? They say yes to themselves. They know they're worth it, and they're curious about some of the different options I share a ton of very entertaining education, like, I shared some sleep stuff like, why (inaudible) sleeps because I took creatine too late after my workout. But how did I hack that not so great sleep? I took a little bit more in the next day because it fires up your ATP, anyways, funny stuff like that. As a biohacker and also in the med spa space is over @RachelVargaOfficial, that's my Instagram handle. And then the podcast, really great show, the School of Radiance podcast. And then theschoolofradiance.com is my website, where you can book a one-on-one. You can join my seasonal skin tutorials, where I actually show you how to do Gua Sha, do your skincare, your makeup, your dermarolling peels, retinols, what rejuvenation is great to do that time of year, so basic and advanced stuff over six weeks, great. Not a YouTube tutorial. It's way better. Lesley Logan 45:13  I'm already in. I'm like, hold on, I need to. Rachel Varga 45:15  Super fun, super fun, right? And then the membership is more of that high level. How do we actually activate this radiance and stuff so we can enjoy our lives better and make more money in the process? Those are the two key metrics you're gonna get benefits from.Lesley Logan 45:30  Amazing. You guys, we have a promo code for you in the show notes and everything, so make sure that you check that out. I already have an appointment booked because I am really excited. And it's, again, not because of it's like, oh, I'm trying to be vain. I'm trying to be something that the world wants. No, it's so that when I look in the mirror, I feel awesome about myself, and I can show up more and more and do all the things. And so I'm just so grateful that our paths crossed. You have given us a lot of great tips. Ladies, get on the creatine. Okay, it's really amazing. There's tons of research. Oh yeah, muscles also, just like, apparently, tons of work on the Alzheimer space, which I'm very excited about. Thank God I've been doing creatine for years. But bold, executable, intrinsic or targeted steps our listeners can take to be it till they see it. What do you have for us? Rachel Varga 46:16  Yeah, the skincare checklist, actually, over at theschoolofradiance.com when you sign up for my newsletter, I have a free 30 minute biohacking lesson too, and use promo code LesleyLogan15 for 15% off of your one-on-one here with m. Creatine, creatine, creatine, yes, high protein, one gram to 1.5 grams of protein per pound of body weight, huge when I started to lift heavy and do those two things, and keep up with the flexibility, mobility that just gave me more inner power, activation, if you will, great for the skin too, and caring for yourself, not just your skincare, not just your rejuvenation, but purifying your environment, air, water, lighting, electromagnetics, eating the right food, then detoxing is a key part, but it's what we do every single day.Lesley Logan 47:07  I love that you brought those things up, because I do a lot of people go on detox all the time, but they don't fix their don't check their water problem. When I lived in L.A., all the water stuff said the pipes were great. Everything is great. You guys, I had arsenic and cadmium in my system. So how, right? So we had to, like, we lived in a 500 square foot apartment and had, like, a $5,000 water system put in, and yes, I took it with me when we moved. But I think it's really important so that you all can support things. Right? These are things you can do at home, with your for yourself and in your environment to help you feel really good. So I am obsessed with these tips. I really am obsessed with you. I can't wait for more conversations together and how people are going to use these tips in your life. You guys, let us know. Tag Rachel Varga, tag the Be It Pod. Share this with the friend who needs to hear it. Sometimes we have friends who are actually overly picking on themselves, and maybe I actually think the words that we talked about here today can really support that and help them understand like, you know what is needed, what is necessary, what is helpful, and then also, if you're starting to feel a little bit out of it yourself, like I, I'm gonna tell you right now, it's really okay to care about how you want to put your hair or how you want to dress, because those things actually help us show up more in the world. And we're we are allowed to take up space. So Rachel, thank you so, so much. And until next time everyone, Be It Till You See It. Lesley Logan 48:23  That's all I got for this episode of the Be It Till You See It Podcast. One thing that would help both myself and future listeners is for you to rate the show and leave a review and follow or subscribe for free wherever you listen to your podcast. Also, make sure to introduce yourself over at the Be It Pod on Instagram. I would love to know more about you. Share this episode with whoever you think needs to hear it. Help us and others Be It Till You See It. Have an awesome day. Be It Till You See It is a production of The Bloom Podcast Network. If you want to leave us a message or a question that we might read on another episode, you can text us at +1-310-905-5534 or send a DM on Instagram @BeItPod.Brad Crowell 49:06  It's written, filmed, and recorded by your host, Lesley Logan, and me, Brad Crowell.Lesley Logan 49:10  It is transcribed, produced and edited by the epic team at Disenyo.co.Brad Crowell 49:15  Our theme music is by Ali at Apex Production Music and our branding by designer and artist, Gianfranco Cioffi.Lesley Logan 49:22  Special thanks to Melissa Solomon for creating our visuals. Brad Crowell 49:25  Also to Angelina Herico for adding all of our content to our website. And finally to Meridith Root for keeping us all on point and on time.Support this podcast at — https://redcircle.com/be-it-till-you-see-it/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Episode Highlights With DaveWhat led to him writing a book about meditation and what surprised him mostWhy meditation is one of the most impactful tools he uses How he went from learning to put butter in coffee on the side of a mountain in Tibet to the father of biohackingWhat makes this book different from any other books about meditationMeditation as it's typically understood is a waste of time- here's whyFalse: Everyone should meditate more (not necessarily)98% of humans were involved in agriculture for the last few thousand years, and how this matters for the personalization of meditation“ If I can trigger you, it means you are a loaded gun”He's woken up at 5 am to meditate for long periods of time and what he learned from thisTechniques that go beyond meditation to amplify the resultsUnderstanding the actual goal of meditation to get real results and not just waste timeSomatic practices and why these can work most quickly The recipe he uses with top executives called the RESET method, which is a somatic practiceDark is one of the most underrated supplements in the world… here's whyHow to change your state, just with lightHow he and I both experienced absolute darkness in a cave (separately), and what we learned from thisYour body processes reality before you have time to thinkWhat's missing from meditation and psychology teaching and how understanding this can be life-changingResources MentionedHeavily Meditated: The Fast Path to Remove Your Triggers, Dissolve Stress, and Activate Inner Peace by Dave AspreySmarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want by Dave Asprey

Discover a little-known Japanese walking technique that outperforms 10,000 steps a day. It boosts fat burning, lowers stress, improves mitochondria, and transforms your metabolism—all in just 15–30 minutes. Perfect for anyone who wants sustainable results without punishment workouts.*Chapters*00:00 – 00:46 My 300 lb journey & the surprising Japanese method00:46 – 01:54 Why mainstream fitness advice fails for fat loss01:54 – 02:37 Walking as the most underrated fat-burning tool02:37 – 04:03 The problem with steps & the Japanese breakthrough04:03 – 05:52 How interval walking works & how to do it05:52 – 09:12 Outdoor hacks that maximize resultsConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Upgrade your biology in 10 minutes with this week's rundown from Dave Asprey. This episode breaks down the six biggest stories in biohacking and health tech, from sleep hormones to mitochondrial rejuvenation, giving you the data you need to live longer, think faster, and perform at your peak. This episode covers: • The Melatonin Heart Warning Everyone Missed A major new study from the American Heart Association reveals that long-term melatonin users face nearly twice the risk of heart failure and 3.5 times higher hospitalization rates. Once considered a harmless sleep aid, melatonin's hormonal effects may disrupt cardiovascular recovery, testosterone, and blood pressure regulation when used nightly. The takeaway: melatonin is a short-term circadian reset tool, not a forever supplement. Source: American Heart Association — newsroom.heart.org/news/long-term-use-of-melatonin-supplements-to-support-sleep-may-have-negative-health-effects • Bryan Johnson's Extreme Microplastics Detox Biohacker Bryan Johnson shared lab-verified results showing an 85% reduction in microplastics in his semen after one year of daily 200°F dry saunas followed by ice packs on the groin. It's not peer reviewed yet, but it'ssparking global discussion about environmental toxins, fertility, and detoxification. Whether or not you follow his protocol, this study highlights how widespread microplastics have become and how heat, sweat, and smarter exposure control may help fight back. Source: New York Post — nypost.com/2025/10/23/health/biohacker-bryan-johnson-got-rid-of-85-of-microplastics-from-his-semen • Urolithin A: The Mitochondrial Molecule That Strengthens Immunity A peer-reviewed human trial published in Nature Aging found that four weeks of daily Urolithin A (Mitopure®) supplementation improved immune function in adults aged 45–70, increasing youthful CD8 T-cells, natural killer cells, and mitochondrial performance inside immune cells. By triggering mitophagy, your body's cleanup process for old mitochondria, Urolithin A enhances energy, resilience, and immune strength. It's the clearest evidence yet that we can modulate immune aging through mitochondrial renewal. Head to timeline.com/dave to get 10% off your first order. Source: BioSpace — biospace.com/press-releases/timeline-continues-to-build-the-most-clinically-researched-longevity-products-targeting-immune-brain-and-muscle-aging • Google's New AI Model That “Talks” to Cells Google DeepMind and Yale launched Cell2Sentence-Scale, an open-source AI model that lets scientists query cellular pathways in natural language. The system can predict how cells transition from healthy to cancerous states and identify molecular switches that might reverse those changes. It's compressing years of biology into days and democratizing research for small labs and independent scientists alike. Isn't AI a beautiful thing? Source: Google DeepMind — blog.google/technology/ai/google-gemma-ai-cancer-therapy-discovery • Omega-3s Calm the Brain and the Temper A massive new meta-analysis of randomized controlled trials shows omega-3 fatty acids (EPA and DHA) reduce aggression by up to 28%. That includes both reactive anger and planned aggression. By lowering neuroinflammation and stabilizing cell membranes, omega-3s appear to balance dopamine and serotonin, proving that healthy fats aren't just heart food, they're emotional regulators too. Source: Science Alert — sciencealert.com/one-dietary-supplement-was-shown-to-reduce-aggression-by-up-to-28 • Chronic Fatigue Syndrome Finally Gets a Biomarker For the first time, researchers have developed a blood test that accurately identifies chronic fatigue syndrome (ME/CFS) using DNA methylation and micro-RNA expression patterns. This breakthrough distinguishes CFS from other autoimmune and viral conditions, marking a turning point for millions of patients long dismissed by traditional medicine. It's proof that data-driven diagnostics can transform how we understand mystery illnesses. Source: Science Daily — sciencedaily.com/releases/2025/11/251102205021.htm All source links provided for easy reference to the original reporting and research above. This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: melatonin heart risk, sleep hormones, microplastics detox, Bryan Johnson, Urolithin A, mitophagy, mitochondrial health, immune aging, DeepMind AI, cellular modeling, omega-3 aggression, neuroinflammation, chronic fatigue biomarker, ME/CFS test, biohacking news, longevity research Thank you to our sponsors! -LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser.-Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Intro 0:18 — Story 1: Melatonin & Heart Health 1:58 — Story 2: Microplastics Detox 3:39 — Story 3: Urolithin A & Immune Function 5:19 — Story 4: AI Cell Model 6:57 — Story 5: Omega-3 & Aggression 8:43 — Story 6: CFS Blood Test 9:59 — Weekly Upgrade Protocol See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Pain isn't just in your body, it's in your brain. In this groundbreaking episode, Host Dave Asprey sits down with Dr. Daniel Amen to reveal how emotional and physical pain share the same neural circuits and how you can rewire them for relief, resilience, and longevity. You'll learn practical tools to break the “doom loop” of pain, restore neuroplasticity, and retrain your brain for calm, healing, and high performance. This is essentiallistening for anyone ready to stop managing pain and start hacking it. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR The Washington Post called Dr. Daniel Amen the most popular psychiatrist in America. He is a former infantry medic and board certified child and adult psychiatrist who trained at the Walter Reed Army Medical Center in Washington, DC. He is the CEO and founder of Amen Clinics, with 11 locations nationwide and home to the world's largest brain imaging database for psychiatry with nearly 300,000 SPECT scans on patients from 155 countries. Dr. Amen is a 12 time New York Times bestselling author, including the books Change Your Brain, Change Your Life, Healing ADD, Memory Rescue, Raising Mentally Strong Kids, and The End of Mental Illness. He has published over 90 scientific articles and led groundbreaking brain imaging research on NFL players, childhood trauma, negativity bias, reversing brain aging, obesity and the brain, and predicting treatment responses. With over 10 million followers and multiple PBS specials, his mission is bold: to end mental illness by creating a revolution in brain health. His newest book Change Your Brain, Change Your Pain explores the neuroscience of pain and how to heal it through brain optimization and functional medicine. Host Dave Asprey and Dr. Amen uncover how suppressed emotions, inflammation, gut health, and mitochondrial function all influence pain and what you can do to reverse it using biohacking, functional medicine, and supplements. They explore how chronic pain rewires neural pathways, how to activate your brain's natural calming switch, and why techniques like hypnosis, red light therapy, rage journaling, and havening can restore balance to your nervous system. You'll also learn the surprising links between aspartame, Tylenol, and generational anxiety, and how to protect your mitochondria to optimize energy, metabolism, and emotional resilience. This episode delivers practical, science based tools for brain optimization, sleep optimization, neuroplasticity, and anti aging while connecting the dots between biohacking, psychology, and functional medicine to help you live smarter not harder. You'll Learn: • How emotional pain and physical pain run on the same brain circuits • Why suppressed rage can trigger chronic pain and how to release it • The link between inflammation, gut health, and brain suffering pathways • How supplements like saffron, curcumin, and omega 3s support pain relief and mood • Why red light therapy, hypnosis, and havening boost neuroplasticity and calm the nervous system • How environmental toxins, aspartame, and Tylenol disrupt mitochondria and increase pain • Simple daily habits to retrain your brain for resilience, optimism, and longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: chronic pain neuroscience, emotional pain circuits, Change Your Brain Change Your Pain, Dr. Daniel Amen, Dave Asprey, biohacking, neuroinflammation, anterior cingulate cortex, SPECT imaging, mitochondrial metabolism, functional psychiatry, neuroplasticity, rage therapy, havening technique, red light therapy, saffron supplements, aspartame toxicity, gut brain axis, trauma healing, pain hacking BrainMD Happy Saffron Plus: Affiliate Link: https://www.awin1.com/cread.php?awinmid=89351&awinaffid=855302&ued=https%3A%2F%2Fbrainmd.co…Dave's 15% OFF Discount Code: DAVE15Please note – works on one-time purchases or the first order of a subscription.Thank you to our sponsors! • AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. • NeuroVeda Health | Go to https://www.neurovedahealth.com/aspery to learn more and book your week. • BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. • ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Dave's Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated• Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 — Trailer 01:25 — Dr. Amen's Brain Scan Research 02:11 — Physical vs Emotional Pain 05:15 — Childhood Trauma and Pain 08:10 — The Doom Loop Explained 14:01 — Havening Technique 18:27 — Training Positivity and Hope 22:11 — Rage Therapy and Journaling 26:44 — COVID and Brain Inflammation 29:41 — Mitochondria and Energy 36:14 — Pain Relief Protocol 39:32 — Saffron for Pain 43:28 — Aspartame and Anxiety 47:30 — Pain Switches in the Brain 50:50 — Red Light Therapy 52:39 — Fear and Pain Loops 56:36 — Environmental Toxins58:21 — Final ThoughtsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Fan Favorite episode of the Second in Command Podcast, Cameron Herold speaks with Anna Collins, President and COO of Bulletproof, the globally recognized brand behind Bulletproof Coffee, supplements, and biohacking products designed to help people perform better, think faster, and live healthier lives. She is also a Board Member of Ladies Who Launch.Before joining Bulletproof, Anna led multi-billion-dollar businesses at Amazon, Microsoft, and CVS Health, bringing a data-driven, operational mindset to every stage of growth. In this conversation, she reveals how she helped Bulletproof evolve from a niche “biohacker” brand into a household name—streamlining operations, tightening focus, and scaling omnichannel distribution without losing its visionary edge.Anna also shares her leadership principles, from managing a founder with 100 ideas a day to running metrics-driven weekly business reviews that keep innovation grounded in reality. Her insights bridge the gap between entrepreneurial chaos and corporate discipline, showing how great COOs turn vision into execution.Timestamped Highlights[00:00:00] – Cameron introduces this episode as one of the most downloaded in show history.[00:01:14] – Anna's career journey: from Microsoft and Amazon to joining Bulletproof.[00:03:52] – Why she left Amazon Prime for a mission-driven brand.[00:05:36] – What convinced her Bulletproof wasn't just a fad—but a real performance enhancer.[00:06:23] – Partnering with Dave Asprey: defining roles between visionary and operator.[00:07:18] – The challenge of narrowing focus when everything looks like a good idea.[00:08:54] – Bringing Amazon's frameworks—tenets, principles, and data mechanisms—into Bulletproof.[00:10:07] – How structure helped Dave trust the team and delegate.[00:10:26] – Shutting down international markets and cutting SKUs to simplify growth.[00:11:59] – Expanding into Amazon marketplace and corporate distribution channels.[00:13:28] – Convincing the founder to “grow beyond the core biohacker.”[00:17:00] – Managing an idea-rich founder without stifling creativity.[00:18:37] – Anna's leadership philosophy: define reality, create possibility, say thank you.[00:21:00] – Rebuilding Bulletproof's vision, mission, and values for clarity and culture.[00:24:20] – Weekly Business Reviews: the data-driven rhythm behind execution.[00:30:32] – How Anna divides her focus across key stakeholders—customers, team, and growth.[00:36:35] – Simplifying the Bulletproof brand for mainstream accessibility.[00:38:00] – Where she struggles as a leader—and the balance between speed and empathy.[00:42:33] – The advice she'd give her 21-year-old self: don't take it all so seriously.About the GuestAnna Collins is the President and COO of Bulletproof overseeing strategy, operations, and omnichannel growth for the globally recognized biohacking brand. Previously, she led billion-dollar initiatives at Amazon, where she managed global Prime membership programs, and at Microsoft, where she built the search advertising business from concept to $1.6B in revenue. She is also a Board Member of Ladies Who Launch.A Harvard MBA and transformational leader, Anna specializes in building scalable systems that bridge creative vision with operational discipline. At Bulletproof, she's helped expand the company from its core biohacker audience to a broader wellness market—making human optimization accessible to everyone.

This episode is sponsored by Magnesium Breakthrough and Sleep Breakthrough — two of my favourite biohacks for deeper sleep and better recovery. Right now you can get 15 % off either one when you use the code TONY15 at bioptimizers.com/tony   My guest today is genetic expert and epigenetic performance coach Chris Barnes. He delivered a keynote in Australia at Wanderlust Wellspring, alongside the biggest names in longevity such as Wim Hof, Dave Asprey and more.  But what's his daily biohacking routine?  Check out his work here.    THIS SHOW IS BROUGHT TO YOU BY: BiOptimizers Sleep Breakthrough and Magnesium Breakthrough These are BIOptimizers sleep and magnesium supplements which I take every night.  I have also been using the new Magnesium Breakthrough drink - delicious way to get magnesium. I have been putting a scoop in my protein shake after a workout.  Just go to BIOptimizers.com/tony and use code TONY15 for at least 15% off (often more). Code works worldwide, and on all their products.

Your body does not just run on food or supplements. It runs on energy and information. This episode reveals how to harness that energy for faster recovery, stronger mitochondria, and better emotional resilience. You will learn how energy fields, frequency, and information medicine are reshaping the science of human performance, longevity, and anti-aging. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Harry Massey, a British entrepreneur, filmmaker, and visionary in the field of bioenergetics. In his 20s, Harry's health collapsed after a series of physical injuries, viral infections, and emotional trauma left him bedridden for seven years with chronic fatigue syndrome. Conventional medicine could not provide answers, so Harry began studying energy and information as the missing foundations of human health. His discovery of the pioneering research of Australian scientist Peter Fraser led to a breakthrough. Using Fraser's early frequency-imprinted remedies, Harry experienced a dramatic recovery and went on to co-found NES Health, now Energy4Life, to bring this new field of bioenergetics to the world. Backed by published studies at UC San Diego showing a 22 percent increase in mitochondrial efficiency and the activation of more than 1,000 genes for cell resilience, Harry's work unites ancient healing wisdom with modern physics, light therapy, and quantum biology. Together, Dave and Harry explore how bioenergetics, light frequencies, and digital information enhance neuroplasticity, metabolism, and sleep optimization more effectively than supplements or nootropics alone. You will discover how trauma drains energy, how to restore it through the body's natural field communication systems, and how wearable tech and AI are transforming functional medicine. You'll Learn: • How bioenergetic wearables increase mitochondrial energy by 22 percent • Why emotional trauma and energy leaks accelerate aging • How structured water and light frequencies store biological information • The connection between quantum biology, neuroplasticity, and healing • How energy fields regulate longevity, metabolism, and brain optimization • Why AI-powered diagnostics and frequency medicine are the next frontier in biohacking Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: energy healing, bioenergetics, Harry Massey, Dave Asprey, Energy4Life, NES Health, Infoceuticals, GEM wearable, frequency medicine, energy field, quantum biology, mitochondria, neuroplasticity, functional medicine, human performance, longevity, sleep optimization, anti-aging, metabolism, trauma healing, brain optimization, light therapy, structured water, information medicine, UCSD study, Peter Fraser, energy medicine, energy hacking, biohacking, nootropics, supplements, ketosis, fasting, AI, smarter not harder, Danger Coffee **Grab a generous discount from Harry at https://www.e4l.com/Dave. **Thank you to our sponsors! -BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order. -AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15• Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Trailer 1:25 – Seven Years Bedridden 3:50 – Three Traumatic Events at 21 6:43 – Searching for Answers 9:02 – Meeting Peter Fraser in LA 11:10 – Dave's Skepticism About Homeopathy 17:42 – The GEM Wearable Device 20:29 – Mitochondrial Efficiency Research 27:05 – Body as Signaling Networks 30:49 – Challenging the Chemical Model 35:10 – Biohacking and Ancient Practices 36:15 – Future of Bioenergetics 44:40 – Closing Thoughts on Energy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if mastering your metabolism wasn't just about food, fasting, or fitness — but about transforming your inner world? Purchase Dave Asprey's new book Heavily Meditated here: https://amzn.to/3LlrKQ0 In this in-person episode of the Metabolic Freedom Podcast, Ben Azadi sits down with Dave Asprey, the Father of Biohacking, in Austin, Texas, for a powerful conversation that bridges science, spirit, and self-mastery. Together they explore how your mitochondria — the energy-producing engines inside every cell — also shape your emotions, mindset, and ability to heal. Dave shares insights from his new book, Heavily Meditated, revealing how practices like gratitude, forgiveness, and meditation can unlock a deeper level of metabolic and emotional freedom. You'll hear how trauma drains your energy, how fasting and breathwork boost mitochondrial intelligence, and why taking control of your biology starts with mastering your inner state. This episode blends cutting-edge science with timeless wisdom. If you're ready to stop living reactively and start consciously programming your own operating system, this one's for you.

This episode is sponsored by Magnesium Breakthrough and Sleep Breakthrough — two of my favourite biohacks for deeper sleep and better recovery. Right now you can get 15 % off either one when you use the code TONY15 at bioptimizers.com/tony   There are biohacking events happening all over the world right now. And what is emerging is a remarkable template for longevity.    Saudi Arabia and Australia have been two of the notable ones in the last few days, and they're pushing the limits of what's possible for health and human performance. My guest today is genetic expert and epigenetic performance coach Chris Barnes. He delivered a keynote in Australia at Wanderlust Wellspring, alongside the biggest names in longevity such as Wim Hof, Dave Asprey and more.  Check out his work here.    THIS SHOW IS BROUGHT TO YOU BY: BiOptimizers Sleep Breakthrough and Magnesium Breakthrough These are BIOptimizers sleep and magnesium supplements which I take every night.  I have also been using the new Magnesium Breakthrough drink - delicious way to get magnesium. I have been putting a scoop in my protein shake after a workout.  Just go to BIOptimizers.com/tony and use code TONY15 for at least 15% off (often more). Code works worldwide, and on all their products.    

What if getting older had less to do with your birthday and more to do with the health of your cells? Some people in their 50s feel stronger and sharper than ever, while others feel decades older than they are. The difference isn't luck or expensive treatments. In this video, you'll learn what really drives aging, how to measure it, and the surprising practices that can help you feel younger, stronger, and more focused right now.Chapters0:00 – Introduction0:21 – Why aging isn't about time0:49 – Biological age vs chronological age1:40 – Cellular dysfunction and mitochondria3:00 – How weak mitochondria accelerate aging4:00 – Turning on your body's switch6:44 – REHIT workouts to build new mitochondria8:45 – Fueling with fats for clean energy10:05 – Your body's deep clean process13:56 – Fasting methods that support renewal15:58 – The hidden factor: chronic stress19:02 – Stress hacks to unlock longevityConnect with Dave Asprey!Thank you to our sponsor!-MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Discover how quantum energy, frequency medicine, and consciousness science are rewriting what's possible for human performance and longevity. This episode reveals how your biofield, mitochondria, and brain can be trained, just like your muscles, to achieve higher focus, deeper resilience, and accelerated healing. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Philipp Samor von Holtzendorff-Fehling, founder and CEO of Leela Quantum Tech, about the cutting-edge research proving that quantum energy can neutralize EMF damage, improve neuroplasticity, and activate self-healing at the cellular level. A former telecom executive turned energy researcher, Philipp has led dozens of double-blind, placebo-controlled studies validating measurable shifts in brain waves, ATP production, blood flow, and human coherence. You'll learn how quantum energy interacts with your nervous system, mitochondria, and electromagnetic environment to unlock higher states of consciousness and energy. Philipp and Dave dive into the science behind biofield technology, the real dangers of 5G and EMFs, and how to use frequency devices, structured water, and energetic optimization to enhance your metabolism, sleep quality, and emotional stability. You'll Learn: • How quantum energy measurably enhances brain coherence, ATP production, and longevity • Why EMFs disrupt your mitochondria, and the proven ways to neutralize their effects • How frequency medicine and structured water improve resilience and energy levels • What double-blind studies reveal about human performance, neuroplasticity, and healing • How to integrate quantum tech with fasting, nootropics, and supplements for full-body optimization • The role of consciousness and energy fields in unlocking true anti-aging and human potential This conversation bridges biohacking and functional medicine, exploring how quantum biology complements nootropics, fasting, ketosis, and supplements to accelerate anti-aging and brain optimization. You'll walk away with a new understanding of energy as the missing link in hacking your biology and extending your longevity. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: quantum energy, Leela Quantum Tech, Philipp Samor von Holtzendorff-Fehling, biohacking, EMF protection, frequency medicine, human performance, mitochondria, neuroplasticity, ATP production, brain optimization, anti-aging, functional medicine, structured water, consciousness, energy healing, nootropics, sleep optimization, longevity, quantum biology **Go to https://leelaq.com/dave for a discount on Leela Quantum!**Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Intro 7:04 — Why Quantum is Controversial 10:11 — How Quantum Healing Works 14:47 — EMF Effects on the Brain 17:35 — Living in the EMF Soup 20:55 — Elon Musk and EMF Denial 22:32 — How Leela Quantum Technology Works 26:29 — Water Optimization Research 34:54 — Charging Clothing and Objects 37:31 — Frequency Medicine Applications 42:03 — Skeptics Turned Believers 55:40 — The Energy of Everything (Book Launch) 59:05 — Quantum Upgrade Service Settings 1:02:21 — Protection from Negative Energy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Heart rate variability isn't just a fitness metric, it's the master signal of human performance, emotional regulation, and longevity. This episode reveals how you can use HRV to hack your nervous system, regulate stress in real time, and build true resilience from the inside out. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Rollin McCraty, Ph.D., Director of Research at the HeartMath Institute and a leading psychophysiologist exploring how the heart, brain and human consciousness are interconnected. For more than three decades his pioneering research into heart-brain communication and geomagnetic field interactions has supported the development of HRV/coherence-training tools and coherence biofeedback technology. His work has been featured in documentaries such as I Am, The Power of the Heart and The Living Matrix. Together, Dave and Dr. McCraty uncover how heart-brain coherence can improve neuroplasticity, optimize sleep, strengthen mitochondria, and create emotional stability even under extreme stress. You'll discover how five minutes a day of coherence training can elevate focus, resilience, and connection, helping every other biohack, from fasting and ketosis to supplements and nootropics, work more effectively. You'll Learn: • What HRV really measures and why it predicts performance and longevity • How coherence breathing balances your nervous system and sharpens cognition • Why emotional regulation begins in the heart, not the mind • How environmental and solar energy affect your physiology, and how to stay stable • The Navy-proven HRV method for better sleep and stress recovery • How coherence training outperforms traditional meditation for daily resilience • The measurable science behind “radiating love” and creating heart-based connection This is essential listening for anyone serious about biohacking, brain optimization, functional medicine, and anti-aging. Whether you're optimizing metabolism, fine-tuning sleep, or upgrading your energy with Danger Coffee, coherence training helps you live smarter, not harder, by syncing your biology with the rhythm of life itself. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: heart rate variability, HRV training, HeartMath, Rollin McCraty, heart-brain coherence, biohacking, emotional regulation, nervous system, stress resilience, neuroplasticity, longevity, sleep optimization, mitochondria, functional medicine, anti-aging, coherence breathing, vagus nerve, HRV recovery, brain optimization Go to https://www.heartmath.com/Dave for 15% off the HeartMath device Thank you to our sponsors! -Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. -BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • HeartMath Instagram: https://www.instagram.com/heartmath/ • HeartMath Facebook: https://www.facebook.com/HeartMath • HeartMath TikTok: https://www.tiktok.com/@heartmathinc • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — OG Biohacker 3:21 — What Is Heart Rate Variability? 7:10 — The Four Drummers: Understanding HRV Rhythms 11:50 — Real-Time Training vs Sleep Tracking 18:45 — The Science of Coherence and Consciousness 21:25 — Heart Synchronization in Groups 26:40 — Space Weather and Planetary Rhythms 31:40 — Solar Flares and Human Behavior 38:45 — The Emotional System Runs the Show 49:15 — Getting Started: Training Protocol 57:55 — Advanced Applications: Dating to Performance 1:01:46 — The Frequency Spectrum of Love 1:05:15 — The Heart's Magnetic Field and Congruence See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Discover how decoding your DNA can unlock the full potential of plant medicine. This episode delivers a cannabis masterclass for biohackers, revealing how personalized genetics are transforming human performance, brain optimization, and longevity. You'll learn how to identify your ideal cannabis and supplement protocols, balance your endocannabinoid system, and turn precision data into powerful healing. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Len May, MSc, visionary authority in personalized medicine and CEO of EndoDNA, the world leader in DNA-based wellness technology. With over 25 years of pioneering work in genomics, epigenetics, and medicinal cannabis, Len's patented DNA decoding system maps your unique genotypes to design tailor-made health solutions. His company holds the world's largest real-world efficacy database in precision wellness, integrating functional medicine, AI-driven analytics, and genetic data to create personalized blueprints for optimal brain function and performance. Together, Dave and Len explore how your genetic code determines how you respond to cannabis, psychedelics, nootropics, and supplements—and how to use that data to reduce anxiety, improve sleep optimization, and enhance focus. You'll learn how decoding your DNA can guide anti-aging strategies, mitochondrial performance, metabolism, and neuroplasticity, revealing new ways to live longer and smarter. This episode dives deep into the intersection of cannabis science, genomics, and biohacking. You'll discover how genetic polymorphisms influence mood, cognition, and stress response, and how personalized medicine can help you make smarter decisions around ketosis, fasting, and recovery. From optimizing the endocannabinoid system to hacking your biology for resilience and longevity, this is the future of functional medicine in action. You'll Learn: • How the endocannabinoid system regulates mood, focus, pain, and stress response • Which genetic polymorphisms affect cannabis sensitivity, anxiety risk, and dosing windows • How to use DNA testing to select cannabinoid and terpene ratios that fit your biology • Why delivery method matters and when sublingual dosing outperforms inhalation • How personalized cannabis protocols can support sleep optimization, recovery, and emotional regulation • The role of cannabinoids in mitochondrial function, neuroplasticity, and cognitive performance • How pharmacogenomics reduces antidepressant side effects and improves treatment matching • How to screen genetics for safer psychedelic use and avoid adverse reactions • What HLA and related markers reveal about mold sensitivity and inflammation This is essential listening for anyone serious about biohacking, brain optimization, longevity, anti-aging, functional medicine, and living Smarter Not Harder—with precision tools designed to upgrade your mind and body at the genetic level. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: cannabis biohacking, cannabis masterclass, Dave Asprey cannabis, DNA decoding, genetic testing for cannabis, personalized medicine, endocannabinoid system, cannabis genomics, cannabis and DNA, cannabis and genetics, cannabis nootropics, plant medicine biohacking, cannabis brain optimization, cannabis and neuroplasticity, cannabis for focus, cannabis and mitochondria, cannabis metabolism, cannabis for sleep, cannabis anti-aging, precision wellness, functional medicine, cannabis longevity, EndoDNA, Len May, cannabis and AI, biohacking genetics, cannabis and fasting, cannabis and ketosis, personalized supplements, cannabis and mood, cannabis stress response, genetic biohacking, cannabis cognitive performance Thank you to our sponsors! -Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. -Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. -iRestore | Use code DAVE at https://www.irestore.com/ to unlock an exclusive discount on the iRestore Elite. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 – Trailer • 1:25 – Introduction • 7:02 – Cannabis & The Endocannabinoid System • 13:30 – How It Works • 21:38 – Brain Health & Clinical Studies • 26:52 – Psychedelics & Genetic Testing • 31:37 – Genetics vs Epigenetics • 34:53 – Antidepressant Safety • 40:41 – Cannabis Success Stories • 46:02 – ADHD & Personality Genes • 50:54 – Mold, Nicotine & Mitochondria • 55:27 – GLP-1 & Metabolism • 1:00:34 – Microbiome & Medical Freedom See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dopamine isn't the enemy—low brain energy is. When your mitochondria can't make enough ATP, your neurons misfire, leading to fatigue, brain fog, and lack of focus. In this video, I explain why dopamine problems are really energy problems, how mitochondrial health drives motivation and clarity, and why creatine is one of the most effective and affordable nootropics for restoring mental performance. Learn the biohacks that protect your brain's power plants and keep you sharp all day long.Chapters0:00 – Introduction0:22 – Brain energy vs dopamine0:49 – ATP shortage causes fatigue1:53 – Prefrontal cortex and energy3:08 – Why ATP fuels focus and mood4:40 – Stress, sleep and mitochondria6:00 – Biohacks for energy production7:39 – Backup battery: phosphagen system8:46 – Creatine for brain energy & focus13:18 – Vegans, women and creatine needs15:07 – Best practices for dosing creatine17:53 – Daily creatine + electrolytesThank you to our sponsors!-ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Upgrade your biology in 10 minutes with this week's rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.This episode covers:• Vitamin D as the Surprising “Anti-Aging Pill”A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn't just for bones anymore — it's a foundational longevity molecule.Source: Science Daily — https://www.sciencedaily.com/releases/2025/10/251022023132.htm• The Supercentenarian Gene That Rejuvenates Old HeartsResearchers at the University of Bristol identified a gene variant, LAV-BPIFB4, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It's a glimpse into how gene therapy could soon democratize superhuman longevity.Source: University of Bristol News — https://www.bristol.ac.uk/news/2025/october/progeria.html• FDA Closes the “GRAS” Loophole — Supplements Enter a New EraThe FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It's the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.Source: Mintz FDA Flux Newsletter — https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter• Microbes That Trigger Autophagy — Your Gut as an Anti-Aging SwitchScientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body's built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.Source: University of Basel — https://www.unibas.ch/en/News-Events/News/Uni-Research/Longevity-research—Dietary-stress-supports-healthy-aging.htmlFurther reading: Neuroscience News — https://neurosciencenews.com/dietary-rna-cellular-aging-29757/• Your Medical Avatar Is Coming — The Digital Twin of YouForbes reports on the rise of personalized “medical avatars” — AI-powered digital twins built from your wearables and biometrics that can predict health risks, recommend interventions, and evolve alongside your biology. Doctors like Daniel Kraft call it generative health — a revolution in predictive medicine where your data literally becomes your doctor.Source: Forbes Innovation — https://www.forbes.com/sites/johnwerner/2025/10/21/wearables-ai-and-your-personal-medical-avatar/This is essential listening for fans of biohacking, human performance, functional medicine, and longevity sciencewho want real, actionable tools from Dave Asprey — the father of biohacking and founder of Bulletproof Coffee.With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your lifespan, and upgrade every system in your body and mind.New episodes drop every Tuesday, Thursday, Friday, and Sunday. Dave asks the questions no one else will — and gives you the science-backed tools to become stronger, smarter, and more resilient.Keywords: vitamin D longevity, telomeres, BPIFB4 gene, cardiac rejuvenation, supplement regulation, GRAS FDA, autophagy, microbiome, fermented foods, biohacking news, medical avatar, digital twin, predictive medicine, Daniel Kraft, quantum health, wearable AI, Dave Asprey, The Human UpgradeThank you to our sponsors! TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off.HeartMath | Go to https://www.heartmath.com/dave to save 15% off.Timestamps: 0:00 — Introduction0:18 — Story 1: Vitamin D & Telomeres1:02 — Story 2: Longevity Gene Therapy1:49 — Story 3: FDA Supplement Reform2:38 — Story 4: Gut Bacteria & Autophagy3:46 — Story 5: Medical Avatars4:53 — Weekly Protocol5:42 — OutroSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This is Part 2 of the Nicotine Masterclass. If you haven't heard Part 1, start there for a full breakdown of nicotine's mechanisms, myths, and the science behind its misunderstood role in longevity, nootropics, and human performance. Nicotine is one of the most misunderstood nootropics in the world—and one of the most powerful tools for brain optimization and longevity when used correctly. In this episode, Host Dave Asprey breaks down how to harness nicotine for cognitive enhancement, metabolism, and human performance without falling into addiction. You'll learn the real science behind dosage, timing, and cycling, plus how nicotine interacts with mitochondria, acetylcholine, and neuroplasticity to boost focus, motivation, and mental energy. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR This is Part 2 of the Nicotine Masterclass. If you haven't heard Part 1, start there for a full breakdown of nicotine's mechanisms, myths, and the science behind its misunderstood role in longevity, nootropics, and human performance. Host Dave Asprey reveals practical biohacking templates for using nicotine safely and effectively—covering metabolism genetics, stack combinations, and how nicotine fits into a smarter not harder lifestyle. You'll discover how low-dose nicotine can support attention, memory, and even protect against neurodegenerative diseases like Alzheimer's and Parkinson's. Dave also shares his own five-year nicotine protocol, how he avoided dependence, and why nicotine can be a game-changer for brain and mitochondrial performance when used intelligently. You'll Learn: • How to use nicotine as a safe, powerful nootropic for brain optimization and focus • The genetics of nicotine metabolism and why dose timing matters • How to stack nicotine with caffeine, theanine, and rhodiola for maximum energy and motivation • Why nicotine enhances mitochondria and PGC-1α for better metabolism and longevity • The truth about nicotine tolerance, cycling, and how to avoid addiction • How nicotine affects sleep, neuroplasticity, and dopamine signaling • What science says about nicotine's protective effects against Alzheimer's and Parkinson's • How to integrate nicotine into a complete biohacking protocol with fasting, ketosis, and supplements This episode is essential for anyone exploring biohacking, functional medicine, fasting, ketosis, sleep optimization, and cognitive resilience. You'll learn how nicotine stacks with caffeine, theanine, rhodiola, and supplements for sharper thinking and sustained focus—plus the key mistakes to avoid so you don't wreck your sleep or metabolism. Whether you're a seasoned biohacker or just beginning your journey, this episode gives you the science, tools, and protocols to elevate your mind and body safely. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: nicotine biohacking, nicotine masterclass, Dave Asprey nicotine, nicotine nootropics, nicotine cognitive enhancement, nicotine mitochondria, nicotine and dopamine, nicotine addiction prevention, nicotine cycling, nicotine dosage, nicotine metabolism, nicotine tolerance, nicotine and longevity, nicotine patch benefits, nicotine for focus, nicotine and acetylcholine, nicotine and caffeine stack, nicotine sleep effects, nicotine and Parkinson's, nicotine brain optimization ** Listen to part 1 here: https://www.youtube.com/watch?v=WjehLsHaRnE&t=1063s** Thank you to our sponsors! -GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what's in your air. -Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 – Trailer 01:25 – Review of Pt 1 02:48 – Genetics & Metabolism 06:05 – Stacking with Other Compounds 09:23 – Tolerance & Dependence 13:42 – Fertility & Contraindications 17:05 – Real World Use Templates 21:40 – Travel & Jet Lag Protocol 24:29 – Biohacking Lifestyle Integration 25:31 – Longevity & Neuroprotection 28:24 – Medical Applications & Research 31:51 – Final Thoughts & Summary See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Modern joint pain isn't just wear and tear—it's a systemic, metabolic disease that starts years before symptoms show. In this episode, you'll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Kiran Krishnan, a research microbiologist and Chief Scientific Officer at Calroy Health Sciences. He's the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He's a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results. He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You'll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration. You'll learn: • How cartilage cells (chondrocytes) rely on mitochondria for tissue repair • Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog • How cartilage begins to break down in your teens—and what to do about it now • The surprising clinical data on walking distance, inflammation markers, and recovery • Why most supplements and NSAIDs fail—and what actually rebuilds joints • How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal • The mitochondrial link between joint pain, cardiovascular risk, and depression • Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it • How to track your biological joint age using imaging and systemic inflammation labs This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you're lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation **Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave ** Thank you to our sponsors! -BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. -BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order. -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction 2:01 — Why Modern Medicine Fails at Joint Pain 3:07 — Painkillers That Accelerate Joint Damage 7:35 — Rheumatoid vs. Osteoarthritis Explained 8:54 — Cytokines That Destroy Cartilage 12:10 — Arthritis Begins in Your Teens 15:35 — 75% Pain Reduction in 7 Days 18:35 — The Science Behind Boswellia & Celery Seed 24:10 — Six-Minute Walk Test Results 25:45 — The $200/Month Painkiller Trap 28:53 — Proof Cartilage Can Regrow 31:01 — Mitochondria and Joint Repair 32:29 — Inflammation Links to Heart Disease 35:52 — Why Glucosamine Doesn't Work 37:07 — Silent Arthritis in 90% of Adults 40:44 — Why Women Face Higher Joint Risk After 40 45:52 — Food as the #1 Inflammation Trigger 47:23 — Fasting & Cartogenics Stack for Repair 50:27 — Movement Snacks and Efficient Training 55:54 — Why Joints Heal Slower Than Muscles 57:48 — Dave's Stack and Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Biohacking isn't just food + exercise, it's about fixing the invisible disruptors wrecking your biology. EMFs, mold, toxins, mitochondrial stress, these are the real reasons you still feel tired, foggy, or inflamed even on a perfect diet. I've been there. I lost 100 lbs, built Bulletproof Coffee, and discovered why food alone isn't enough. In this video, I'll show you what's actually holding back your energy, focus, and longevity… and how to finally feel truly bulletproof.Chapters:0:00 – Introduction1:30 – The hidden disruptors wrecking your health2:15 – EMFs: invisible energy thieves3:00 – Mold exposure: the silent killer in your home4:00 – How toxins block your nutrients5:10 – Mitochondria: the real source of energy6:20 – Detox hacks that actually work7:30 – Binders: the secret to flushing toxins8:30 – Rebuilding nutrients for lasting energy9:20 – The missing biological switch: nervous system safety10:30 – Resetting your circadian rhythm naturally11:30 – Box breathing: a biohack for instant calm12:20 – Gratitude, digestion & unlocking thrival modeConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Upgrade your biology in 10 minutes with this week's rundown from Dave Asprey. TThis episode covers:• Longevity Scores Are Going MainstreamElegant Hoopoe's new clinics are using 56 biomarkers to track biological aging — and early users are reporting up to six years reversed in under two months. Could scoring systems replace reactive healthcare?Source: Morningstar via PR Newswire — https://www.morningstar.com/news/pr-newswire/20251014ln95054• AI Heart Scans Spot Trouble SoonerHospitals are using machine learning to analyze echocardiograms in real time — making heart diagnostics faster, cheaper, and more accurate, even without top specialists on site.Source: Crescendo.AI News — https://www.crescendo.ai/news/latest-ai-news-and-updates• Brain Training That Rebuilds NeurotransmittersMcGill's INHANCE trial shows that 10 weeks of digital training on BrainHQ doesn't just improve memory — it chemically rejuvenates acetylcholine pathways. That's measurable neuroplasticity.Source: Longevity.Technology — https://longevity.technology/news/brain-training-restores-youth-to-aging-minds/• HLTH 2025 Unveils Digital Twins & Real-Time Immune WearablesThis year's HLTH conference put bio-individuality front and center: AI twins that simulate your biology, hormone-tracking wearables, and apps syncing with EMRs to turn raw data into real decisions.Source: HLTH Official — https://hlth.com/2025event• One Blood Test, Many DiagnosesNew multi-panel tests rolling out in clinics screen for dozens of diseases from a single draw — boosting compliance, streamlining early detection, and making full-spectrum testing routine.Source: Instagram Science Updates — https://www.instagram.com/p/DP0oGGTiiT5/This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: longevity score, elegant hoopoe, AI heart scans, brainHQ, acetylcholine, McGill INHANCE trial, HLTH 2025, digital twins, hormone wearables, immune tracking, biological age, multi-panel blood test, early detection, personalized medicine, Dave Asprey, Human Upgrade, biohacking news, health tech, performance medicine, smart diagnosticsThank you to our sponsors! -SKILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off.-EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction0:18 — Story 1: Elegant Hoopoe Longevity Score1:26 — Story 2: AI-Assisted Echocardiograms2:17 — Story 3: Brain HQ Cognitive Training Study3:03 — Story 4: Digital Twins at HLTH Conference4:13 — Story 5: Single Vial Blood Testing5:04 — Five Day Experiment5:46 — ClosingSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people try to “heal” their brain with supplements, mindset, or meditation—but this episode reveals the deeper protocol to actually grow a new brain, reverse stress damage, activate 1,100 healing genes, and unlock higher human performance at any age. You'll learn how neuroplasticity, mitochondria repair, plant-based NRF2 activators, and energetic practices work together to rebuild the brain and extend longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Alberto Villoldo, Ph.D.—medical anthropologist, neuroscientist, energy medicine pioneer, and founder of The Four Winds Society, the gold-standard school for modern shamans. He has spent 25+ years studying Amazonian and Andean healing traditions, led the Biological Self-Regulation Lab at San Francisco State University to explore psychosomatic medicine, and authored more than 25 bestselling books on neuroscience, functional medicine, and energy healing. Few people on earth bridge ancient biohacking and modern brain science at this level. He also reveals the forms of nicotine that are safest (spoiler: it's not vapes or cigarettes), how nicotine works at the receptor level, and what the science says about long-term health effects. This episode blends functional medicine, brain optimization, and biohacking into one powerful, myth-busting breakdown. You'll learn: • How to grow a new brain every 22 days using neuroplasticity and mitochondria support • Why plant medicines and NRF2 activators can turn on 1,100 healing genes in 24 hours • The surprising link between nootropics, psychedelics, serotonin, and endogenous DMT • How mindset, belief systems, and placebo/nocebo shape immune function and metabolism • Why RFK's chronic disease warning connects to viral evolution and immune collapse • The real reason carnivore diets work—and when they fail without gut repair • Peptides, GLP-1 agonists, and the future of functional medicine hacking • Why most people sabotage themselves and how to stop fighting your own biology This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: NRF2 activation, Neurogenesis and hippocampus repair, Plant-based epigenetic triggers, Psychosomatic health, Serotonin to DMT conversion, Pineal gland methylation, Parasites and brain inflammation, Viral-driven evolution, GLP-1 agonists and longevity, Psilocybin lifespan extension, Autophagy and brain cleanup, Energetic medicine training, Functional peptides, BPC-157, Breathwork and CO2 tolerance, mTOR cycling, Cold exposure and dopamine, Mindset-driven immune function Thank you to our sponsors! • EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. • Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. • Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. • fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Resources: • Learn more from Alberto at: www.thefourwinds.com and www.albertovilloldo.net • Buy the book ‘Grow A New Brain': https://a.co/d/5lVhrVy • Business of Biohacking | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction & Ayahuasca Story 3:15 — Shamanism Beyond Plant Medicine 6:53 — Losing Your Mind to Evolve 10:45 — The 22-Day New Brain Cycle 12:53 — Plant Communication & Direct Knowing 15:35 — Parasites, Liver Failure & Brain Damage 20:25 — Remote Healing & CIA Research 22:40 — Tryptophan, Turkey Farmers & Brain Chemistry 25:19 — Viruses as Evolutionary Drivers 30:30 — Psilocybin & Life Extension 35:25 — Healing with Mindset + Biology 38:52 — Spirit, Purpose & Growing Gods 43:49 — Plants, Protein & mTOR 49:07 — Training the Four Brains 51:16 — Cold Exposure: Pain vs Suffering 54:40 — Who Am I? Living the Question 55:25 — Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Nicotine isn't just addictive—it might be one of the most misunderstood nootropics in modern medicine. In this masterclass, you'll learn how controlled, low-dose nicotine may enhance brain performance, boost neuroplasticity, improve mitochondrial function, and potentially extend lifespan. Host Dave Asprey breaks down the surprising science behind this controversial compound, separating fact from fear—and exposing the real risks that nobody talks about. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll discover how nicotine affects neurotransmitters, why it may help with ADHD and focus, and how it compares to other cognitive enhancers like caffeine, nootropics, and even smart drugs. Dave explores how nicotine can be used to hack metabolism, enhance sleep optimization, and support fasting or ketosis protocols—if used properly. He also reveals the forms of nicotine that are safest (spoiler: it's not vapes or cigarettes), how nicotine works at the receptor level, and what the science says about long-term health effects. This episode blends functional medicine, brain optimization, and biohacking into one powerful, myth-busting breakdown. You'll Learn: • How nicotine affects mitochondria, neurotransmitters, and dopamine signaling • Why nicotine may boost neuroplasticity, memory, and attention span • How low-dose nicotine compares to caffeine, modafinil, and other nootropics • The safest delivery forms (and the ones to avoid) • Whether nicotine supports or hinders longevity and cognitive resilience • How it can be stacked with supplements, fasting, or ketosis • What functional medicine says about chronic use, addiction, and withdrawal This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Nicotine microdosing, Nicotinic acetylcholine receptors, Dopamine and motivation, Cognitive enhancement, Alzheimer's prevention, Neuroinflammation, Mitochondrial function, TNF-alpha reduction, Vagus nerve activation, Longevity biohacking, Nicotine vs smoking, Nootropics, Attention and vigilance, Ketosis and metabolism, Functional medicine, Nicotine patches and gum, Addiction and tolerance, Receptor desensitization, Withdrawal protocols, Deep work performance Thank you to our sponsors! -TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off. -HeartMath | Go to https://www.heartmath.com/dave to save 15% off. -Leela Quantum Tech | Check out all HEAL360 products and research and get 10% off at https://leelaq.com/DAVE. -Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Business of Biohacking | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction 1:27 — History & Background of Nicotine 4:34 — How Nicotine Works 15:12 — Benefits & Research 16:43 — Risks & Who Should Avoid It 21:39 — Delivery Methods & Dosing 26:30 — Conclusion & Next Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

These "toxic foods" are one of the biggest hidden threats to your health and most people are eating them every single day without realizing it. These cheap industrial foods are marketed as “healthy,” but the truth is they damage your cells, drive inflammation, and speed up aging. In this video, I'm exposing the dark history behind how they ended up in our food system, why regulators don't protect you, and the toxic process used to make them.I'll also show you what to cook with instead so you can lower inflammation, protect your brain, and get back the vitality the food industry has been stealing from you. If you care about longevity, energy, and real health, not marketing lies, this is one video you don't want to miss.Chapters:0:00 – Introduction0:50 – What They Don't Tell You About This2:40 – How Healthy Fats Become Toxic Poisons3:40 – The Food Industry's Biggest Switch5:37 – #1: The Everyday Additive That Wrecks Your Brain6:51 – #2: The Snack Food Staple That Fuels Inflammation7:55 – #3: The “Healthy” Oil Used in Engines8:57 – #4: The Candle Wax That Became Food9:40 – #5: The Cooking Oil That Ages You Faster10:23 – #6: The Gasoline Replacement You're Eating11:01 – #7: The Wine Waste Product in Your Pantry12:19 – Bonus: The One Contaminated with Heavy Metals13:59 – How To Protect Yourself & Choose Real Fats15:36 – Final Warning: The Food System Is Rigged_______Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.