Podcast appearances and mentions of Dave Asprey

Creatine is being called a "cognitive super-drug" that feels like "speed without the speed." Influencers are telling you to mega-dose 20 grams a day for brain power, bone health, and more. But what does the science actually say?In this episode, we go beyond the hype and fact-check the wildest creatine claims taking over the internet. I break down the real evidence on mega-dosing, and put the cognitive benefits to the testI react to clips from Paul Saladino, Jeff Cavalier, Rhonda Patrick, and Dave Asprey to separate proven fact from marketing fiction. Discover the simple, science-backed creatine protocol that actually works, and save your money (and your gut) in the process.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/00:01:23 - High-Level Reality Check on Creatine00:03:12 - Hosts' Personal Histories with Creatine00:05:17 - How to Evaluate Health Influencers & Their Claims00:08:40 - Paul Saladino (MD): Analysis of Mega-Dosing Claims (20g/day) for Brain & Bones00:23:16 - Jeff Cavaliere (Physical Therapist): Claims on Depression, Parkinson's, and MS00:31:22 - Discussion on Creatine for Sleep Deprivation & High Stress00:34:28 - The "No Downside" Myth & Side Effects (GI Issues, Microbiome)00:37:29 - Rhonda Patrick (PhD): "Feels Like Speed" Claim & Brain Aging00:46:00 - Dave Asprey: "Most Powerful Cognitive Drug" Claim00:53:02 - How Creatine Actually Works (The "Backup Battery" Analogy)00:53:49 - Final Take-Home Messages & Summary00:56:00 - Q&A: Best Time to Take Creatine & What to Do If You Miss a Day00:57:42 - Final Thoughts on Influencer HypeDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/

This episode covers: • Nano CBD Pain Relief Without Cognitive Side Effects A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support. Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm • Moderate Calorie Restriction Slows Biological Aging A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting. Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults • FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer's The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer's disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair. Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/ • Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.” Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged) • Klotho: The Longevity Protein Nears Clinical Reality The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols. Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged) All source links provided for easy reference to the original reporting and research above. This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer's microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates Thank you to our sponsors! LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. Resources: • Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Intro 0:19 — Story 1: Nano CBD for Pain Relief 1:53 — Story 2: Caloric Restriction and Aging 3:20 — Story 3: AI Robotic Surgery for Alzheimer's 4:50 — Story 4: Microbiome Reprogramming 6:05 — Substack Announcement 7:04 — Story 5: Klotho Longevity Protein 8:39 — Weekly Homework 9:31 — Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Methylene blue is one of the most misunderstood compounds in biohacking, yet it can upgrade your energy, mood, memory, and cellular resilience when you use it the right way. We are back again with another solo masterclass, and this one breaks down how to use methylene blue as a precision tool for brain optimization, longevity, and human performance while avoiding the dosing mistakes that create jitteriness, sleep disruption, or dangerous interactions. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey guides you through more than a century of research on methylene blue. He has been hacking this compound since the early 2000s and brings deep insight into mitochondria, neuroplasticity, metabolism, supplements, fasting, red light, ketosis, nootropics, and functional medicine. You will learn how methylene blue works inside the cell, how it improves electron transport, and why it appears in neurology, psychiatry, and anti aging research at the same time. This episode shows you how to test your own dose, how to stack it with light and ketosis for maximum effect, and how to avoid serotonin syndrome or sleep disruption. Methylene blue also touches nearly every major system that biohackers care about, which is why this solo masterclass shows you how it interacts with mitochondria, neuroplasticity, metabolism, sleep optimization, and long term anti aging pathways. You will hear how it influences redox balance, ATP production, brain optimization, and stress resilience, and how it behaves when combined with ketosis, fasting, creatine, NAD boosters, red light therapy, or other nootropics. Host Dave Asprey explains why methylene blue pairs well with certain supplements but clashes with psychedelics or SSRI medications, how it fits into functional medicine protocols for mitochondrial repair, and how to use data and wearable tracking to dial in your response. This episode gives you a complete framework to evaluate whether methylene blue belongs in your personal longevity strategy and how to use it with precision instead of guesswork. You'll Learn: • Why methylene blue acts like mitochondrial jumper cables and when it improves energy and mood • The exact signs that your dose is too strong, too weak, or in the Goldilocks zone • How methylene blue interacts with neuroplasticity, memory circuits, and cognitive resilience • Why psychedelics, SSRIs, and MAO inhibitors can create dangerous serotonin interactions • How to pair methylene blue with red light therapy, ketosis, creatine, fasting, or NAD boosters • The link between mitochondrial health, fertility, libido, and long term anti aging strategies • How to track sleep optimization, HRV, and performance signals to dial in your personal protocol • The difference between aquarium grade dye and pharmaceutical grade formulations • Why genetic testing for G6PD deficiency is essential before higher dose experimentation Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: methylene blue dosing, mitochondrial electron transport, Complex IV cytochrome c oxidase, redox cycling, MAO inhibition, serotonin syndrome risk, G6PD deficiency caution, neuroplasticity enhancement, dendritic spine density, mitochondrial stress adaptation, red light therapy stacking, cognitive performance optimization, ketone supported ATP production, nitric oxide independent focus boost, mitochondrial bottleneck repair, pharmaceutical grade methylene blue, sleep disruption signals, biohacking fertility support, oxidative stress buffering, functional medicine mitochondria repair Thank you to our sponsors! -BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. -fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction 4:51 — History of methylene blue 7:38 — How methylene blue works 14:05 — Safety 17:53 — Dosing and timing guidelines 20:41 — Combining with red light therapy 22:41 — Quality and sourcing 23:17 — Dosing protocols 25:24 — Longevity and fertility effects 29:24 — Stacking options 32:10 — Common questions and FAQs 33:40 — Future research and wrap up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Eboni Cornish, Associate Medical Director at Amen Clinics and President-Elect of ILADS, breaks down why Lyme disease is just the beginning of the story. As someone who specializes in neuroinflammation caused by chronic infections, she explains how tick-borne diseases, parasites, and mold toxicity don't work alone. They create an inflammatory cascade that crosses the blood-brain barrier, triggers autoimmune responses, and makes recovery from conditions like breast implant illness exponentially harder. From her work analyzing brain scans showing infection-driven inflammation to her clinical insights on why gut stability determines immune stability, Dr. Cornish provides a masterclass in understanding complex chronic illness. You'll learn why standard testing misses most infections, how genetics determine your susceptibility to toxin accumulation, and why the real question isn't IF you have parasites but how much they're contributing to your inflammatory burden. Dr. Eboni Cornish on Instagram: https://www.instagram.com/dr.ebonicornish/ Amen Clinics: https://www.amenclinics.com/ Amen Clinics on Instagram: https://www.instagram.com/amen_clinics/?hl=en ILADS: https://www.ilads.org/ IN THIS EPISODE WE'LL: Discover why Lyme disease is actually three infections (Borrelia, Bartonella, and Babesiosis) that create different symptoms and require clinical diagnosis beyond lab testing. Uncover the connection between HLA genetics and your ability to clear mold toxins, tick-borne diseases, and why some family members get devastatingly sick while others stay healthy in the same environment. Break through the parasite denial that keeps you sick, including why testing is unreliable and how parasites create biofilms with other pathogens to overwhelm your immune system. Transform your understanding of the gut-brain axis and why stabilizing your microbiome isn't optional if you're dealing with neuropsychiatric symptoms, chronic inflammation, or breast implant illness. Learn practical nutrition strategies that meet patients where they are, from working with picky eaters to creating sustainable anti-inflammatory habits without the stress of restriction-based diets. CHECK OUT THESE EPISODES: Episode 116: Is Mold Silently Wrecking Your Health? How to Detox from Mold with Dave Asprey: https://podcasts.apple.com/us/podcast/episode-116-is-mold-silently-wrecking-your-health-how/id1678143554?i=1000708555274 Episode 137: Environmental Toxins Are Messing With Your Body—Here's How to Fight Back with Dr. Aly Cohen: https://podcasts.apple.com/us/podcast/episode-137-environmental-toxins-are-messing-with-your/id1678143554?i=1000730936483   Links and Resources Let's Connect Podcast: https://podcasts.apple.com/gb/podcast/breast-implant-illness/id1678143554 Spotify: https://open.spotify.com/show/1SPDripbluZKYsC0rwrBdb?si=23ea2cd9f6734667 TikTok: https://www.tiktok.com/@drrobertwhitfield?_t=8oQyjO25X5i&_r=1 IG: https://www.instagram.com/breastimplantillnessexpert/ FB: https://www.facebook.com/DrRobertWhitfield Linkedin: https://www.linkedin.com/in/dr-robert-whitfield-md-50775b10/ X: https://x.com/rob_whitfieldmd Read this article - https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/implant-reconstruction/illness/breast-implant-illness Shop: https://drrobssolutions.com SHARP: https://www.harp.health NVISN Labs - https://nvisnlabs.com/ Get access to Dr. Rob's Favorite Products below: Danger Coffee - Use our link for mold free coffee - https://dangercoffee.com/pages/mold-free-coffee?ref=ztvhyjg JASPR Air Purifier - Use code DRROB for the Jaspr Air Purifier - https://jaspr.co/ Echo Water - Get high quality water with our code DRROB10 - https://echowater.com/ BallancerPro - Use code DRROBVIP for the world's leader in lymphatic drainage technology - https://ballancerpro.com

Bioelectronic medicine is changing how we treat inflammation, autoimmunity, and chronic disease, and this episode shows you exactly how nerve stimulation could redefine human performance, longevity, and brain optimization. You will learn how electricity, neurotransmitters, and targeted neural pathways can replace drugs, control inflammation, and help you hack the vagus nerve with precision instead of guesswork. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey is joined by Kevin J. Tracey, MD, president and CEO of the Feinstein Institutes for Medical Research at Northwell Health, pioneer of vagus nerve research, and author of The Great Nerve. He is one of the world's most cited scientists in inflammation and neuroscience, and his discoveries created the field now known as bioelectronic medicine. He identified the therapeutic action of anti TNF antibodies, mapped the inflammatory reflex, and revealed how vagus nerve signaling controls immunity. With more than 450 scientific publications and over 120 U.S. patents, he is a trusted authority whose work drives the future of anti-aging, functional medicine, metabolism, and neural therapies. Dr. Tracey and Host Dave Asprey explore how the vagus nerve truly operates, why it contains 200,000 fibers with different functions, and what happens when you stimulate specific pathways that regulate inflammation, HRV, neurotransmitters, and immune signaling. You will learn how nerve impulses transmit information, how voltage gated ion channels shape behavior and biology, and why certain forms of stimulation create measurable improvements in mitochondria, metabolic control, sleep optimization, and emotional regulation. They break down the science behind surgical vagus nerve implants, focused ultrasound, gamma entrainment, cytokine control, and real neuromodulation. They also explore why cold plunging, breath work, HRV training, nootropics, and consumer devices vary so widely in their effects, and how to evaluate these tools with practical biohacking frameworks. You will hear what actually works, what remains experimental, and what the next decade of nerve based therapies could unlock for brain optimization, longevity, ketosis, fasting, supplements, and AI guided interventions in human biology. You'll Learn: • How vagus nerve stimulation reduces inflammation through the inflammatory reflex • Why bioelectronic medicine can replace drugs in autoimmune conditions • How nerve fibers relay electrical and chemical signals inside the body • Why cold immersion, breath work, and HRV training activate specific vagal pathways • How 40 hertz gamma entrainment may influence cognitive decline • Which stimulation methods have clinical validation and which do not • Why high vagal tone is linked to better metabolism, immunity, and emotional stability • What future nerve based technologies may unlock for human performance Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Kevin J. Tracey, vagus nerve stimulation, bioelectronic medicine, inflammatory reflex, SetPoint Medical, cytokine control, neuromodulation therapy, autonomic nervous system, HRV optimization, inflammation reduction, rheumatoid arthritis treatment, focused ultrasound therapy, gamma entrainment, mitochondrial signaling, anti-aging science, neural pathway hacking, functional medicine research, immune system regulation, brain and body performance, human longevity science Thank you to our sponsors! -AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. -MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. -Calroy | Head to https://calroy.com/dave for an exclusive discount Resources: • Learn More About Kevin's Work: https://feinstein.northwell.edu/institutes-researchers/our-researchers/kevin-j-tracey-md • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:12 - Bioelectronic Medicine 3:23 - FDA Approval 6:48 - RA Treatment Explained 11:35 - Vagus Nerve Function 15:12 - External vs Implanted Stimulation 18:06 - Focused Ultrasound 26:11 - Ear Stimulation Science 30:51 - Clinical Evidence 37:10 - Alzheimer's Link 42:15 - Future Applications 46:48 - Cold Exposure Effects 53:51 - Common Misconceptions 55:38 - Final Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if the secret to living longer wasn't locked in a lab, but hiding in plain sight? And what could lobsters possibly teach us about staying young?Scientists have discovered a remarkable connection between an ancient practice and our cellular aging process - one that celebrities and longevity researchers are quietly using to their advantage. It involves an enzyme in your body that most people don't even know exists, yet it plays a crucial role in how fast (or slow) you age.The twist? You can activate it in just 10 minutes a day, no prescription required.Curious about the biological "switch" that might help you turn back your cellular clock? The answer might surprise you...*Chapters*0:00 – Introduction0:46 – Lobsters and Human Longevity Connection1:14 – Understanding Telomeres and Aging2:26 – How Lobsters Defy Aging3:32 – Rethinking Aging Biology4:53 – The Telomerase Challenge6:43 – Natural Ways to Protect Telomeres9:33 – Meditation's Role in Anti-Aging11:04 – Different Meditation Techniques13:19 – Benefits and Long-Term EffectsResources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com ADS/SPONSORSBodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off.AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers.Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast:https://www.instagram.com/TheHumanUpgradePodcast/https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode covers: • Cocoa Extract Cuts Heart Deaths A massive COSMOS trial found that older adults taking high flavanol cocoa extract daily saw a 27 percent reduction in cardiovascular deaths along with drops in inflammation markers like HSCRP. Women showed unique anti inflammatory cytokine shifts, pointing to a broader longevity effect. Dave explains why cocoa extract is becoming a foundational nutrient for vascular health rather than a dessert ingredient. Source: https://www.sciencedaily.com/releases/2025/09/250926135957.htm • AI Stethoscope for Home Diagnostics Lapsi Health's Keikku 2.0 just became the first FDA cleared AI powered digital stethoscope for both clinicians and home users. It records heart and lung sounds, analyzes them instantly, and flags early warning signs before symptoms appear. Dave breaks down why tools like this move you from reactive to predictive medicine and why they belong in every quantified self toolkit. Source: https://www.prnewswire.com/news-releases/lapsi-health-unveils-keikku-2-0-worlds-first-fda-cleared-digital-stethoscope-with-integrated-ai-scribe-302585083.html?utm_source=chatgpt.com • Beef Organ Supplements Surge Beef organ supplements have exploded more than 8,000 percent this year, driven largely by women reporting improvements in energy, hormones, mood, and skin. Liver, kidney, and heart deliver vitamin A, heme iron, B12, copper, and choline that modern diets often lack. Dave covers sourcing concerns, purity standards, and why this shift reflects a move from fear based nutrition to evolutionary nutrition. Source: https://www.verywellhealth.com/beef-organ-supplement-11710185?utm_source=chatgpt.com • Spirulina for Collagen and DNA Protection New research highlights spirulina's ability to support collagen production, reduce oxidative stress, protect DNA, and improve glucose and lipid balance. It is becoming a staple of eco focused anti aging routines and is driving the viral green stacking trend with chlorella and chlorophyll. Dave explains why spirulina functions as a clean daily defense against oxidative stress. Source: https://www.news-medical.net/news/20250707/Is-Spirulina-the-Next-Anti-Aging-Superfood.aspx • Health Data Privacy Reform A new Senate bill aims to extend HIPAA level protections to wearables, genomic tools, glucose monitors, and wellness apps. The goal is to give users control over who sees their biometrics, how they are stored, and whether they can be sold. Dave outlines why this matters for anyone using Oura, Whoop, CGMs, or genetic testing and why your biology should belong to you and not the cloud. Source: https://natlawreview.com/article/federal-healthcare-update-november-7-2025 All source links provided for easy reference to the original reporting and research above. This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: cocoa extract, flavanols, heart health, nitric oxide pathways, COSMOS trial, AI stethoscope, digital diagnostics, Keikku device, predictive health tech, beef organ supplements, women's hormonal health, nutrient dense foods, ancestral nutrition, spirulina benefits, collagen support, oxidative stress defense, green stacking, chlorella pairing, DNA protection, wearable privacy laws, HIPAA reform, biometric data rights, longevity news, biohacking updates Thank you to our sponsors! Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask. Resources: • Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Intro 0:19 – Cocoa Extract & Heart Health 1:52 – AI Digital Stethoscope 3:01 – Beef Organ Supplements 4:24 – Spirulina for Longevity 5:42 – Substack Announcement 6:53 – Health Data Privacy Reform 8:23 – Weekly Upgrade Protocol 9:46 – Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your workouts may be doing less than you think, and science now proves why. This episode reveals how to build muscle, improve metabolism, and extend longevity in a fraction of the time using blood flow restriction training and intermittent hypoxia. You'll learn how to hack your mitochondria for faster recovery, stronger hormonal balance, and better brain performance without the burnout of high-intensity training. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Dr. Sten Stray-Gundersen, PhD, CSCS, one of the world's leading experts on blood flow restriction (BFR) training and metabolic physiology. With over a decade of research and teaching experience, Dr. Stray-Gundersen has explored how BFR and intermittent hypoxia can improve cardiovascular health, metabolism, and recovery. After earning his doctorate in Exercise Physiology from the University of Texas at Austin, he now serves as an Assistant Professor at the University of South Carolina, where he studies vascular adaptations, cognitive performance, and ergogenic aids. He's also a B Strong master trainer, developing individualized BFR protocols for athletes, military professionals, and everyday people looking to optimize human performance. Together, Dave and Sten uncover how BFR and oxygen cycling unlock powerful adaptations in the body's vascular, metabolic, and hormonal systems. You'll learn how strategic stress signals can trigger nitric oxide production, enhance glucose uptake, improve insulin sensitivity, and supercharge mitochondria for better energy and anti-aging benefits. They also explore how these methods can naturally boost testosterone, growth hormone, and even libido, all while protecting the nervous system and improving recovery. This episode dives deep into biohacking, functional medicine, and smart exercise efficiency, from Zone 2 and REHIT training to nitric oxide signaling, fasting, nootropics, and precision supplementation. Whether your goal is longevity, strength, or sharper cognition, this conversation shows you how to get maximum results with minimal time using the principles of Smarter Not Harder. You'll Learn:• How intermittent hypoxia works at the level of partial pressure and why altitude acclimation upgrades mitochondria and performance• Why hypoxia and muscle contraction increase glucose uptake independent of insulin and improve insulin sensitivity• How blood flow restriction (BFR) accelerates fatigue with light loads to drive hypertrophy, strength, and vascular adaptations• How BFR and hypoxia influence testosterone, growth hormone, nitric oxide, and libido through short, targeted stress• The roles of ENOS, INOS, and NNOS in nitric oxide signaling and what that means for circulation and brain perfusion• Who benefits most from BFR, including athletes, rehab patients, and older adults who cannot lift heavy• Why BFR produces systemic and “proximal” gains, including carryover to glutes and upper body during lower limb training• How to stack BFR with Zone 2, REHIT, and vibration plates for VO2 max, muscle, and time efficiencyDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Sten Stray-Gundersen, blood flow restriction training, B Strong, intermittent hypoxia, mitochondrial function, nitric oxide production, VO2 max, metabolic efficiency, vascular health, testosterone boost, growth hormone release, anti-aging performance, exercise recovery, glucose metabolism, functional medicine, biohacking fitness, REHIT training, Zone 2 optimization, strength and longevity, human performance science Thank you to our sponsors! -KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. -EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. -Leela Quantum Tech | Check out all HEAL360 products and research and get 10% off at https://leelaq.com/DAVE. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • Use code DAVE10 to get a discount on a BFR band today: https://shopify.bstrong.training/products/b-strong-training-system?ref=dave%2F • Dive deeper in Sten's work at: https://bstrong.training/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:25 - Guest Intro 5:40 - Intermittent Hypoxia & Altitude Acclimation 12:11 - Introduction to Blood Flow Restriction (BFR) 22:53 - Systemic Benefits & Who Can Use BFR 30:23 - BFR Effects on Hormones & Libido 40:37 - Nitric Oxide & Vascular Health 48:15 - Zone 2 Training with BFR 54:00 - Advanced Protocols: Stacking BFR 59:15 - Cognitive Enhancement & Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Sara Szal, a Harvard and MIT-trained physician, sits down to unpack why women bear the brunt of autoimmune conditions at rates that keep climbing. She introduces the three-legged stool concept that's required for autoimmune disease to take hold, then breaks down why 95% of her patients show cortisol dysregulation long before they're ever diagnosed with anything. What makes this conversation powerful is that Dr. Szal doesn't just study this academically, she's lived it, going through prophylactic mastectomies and converting her own positive anti-nuclear antibody back to normal through targeted interventions. This is a masterclass in understanding the drift from health to disease and exactly what you can do about it before the soldiers come for you. Learn more about Dr. Sara Szal: https://www.saraszalmd.com/ Buy Sara's books: https://saraszalmd.com/books/ IN THIS EPISODE WE'LL: Discover why your immune system's passport control goes haywire and how sex hormones, mitochondria, and social conditioning create the perfect storm for women to lose tolerance to their own cells Break through the conventional medicine blind spot that only recognizes Addison's or Cushing's while missing the 95% of people whose cortisol patterns are completely dysregulated Transform your understanding of triggers from breast implants to trauma to infections and learn which ones you can actually control (hint: two out of three legs on that stool) Expose the 29% bacterial contamination rate in explant specimens and how biofilms interact with breast tissue to create the downstream inflammatory cascade that mimics classic autoimmune disease Learn the exact protocol Dr. Szal used to convert her positive autoimmune marker to normal, including internal family systems therapy, psychedelic-assisted therapy, and gut healing strategies you can start today CHECK OUT THESE EPISODES: Building a Resilient Gut and Metabolism with Anu Simh: https://www.youtube.com/watch?v=lcLwhow15Qk Mold with Dave Asprey: https://www.youtube.com/watch?v=S4iTfr-kvKo The Shocking Link Between Gut Health & Breast Explant Surgery: https://www.youtube.com/watch?v=hwfnCpB_fQA Links and Resources Let's Connect Podcast: https://podcasts.apple.com/gb/podcast/breast-implant-illness/id1678143554 Spotify: https://open.spotify.com/show/1SPDripbluZKYsC0rwrBdb?si=23ea2cd9f6734667 TikTok: https://www.tiktok.com/@drrobertwhitfield?_t=8oQyjO25X5i&_r=1 IG: https://www.instagram.com/breastimplantillnessexpert/ FB: https://www.facebook.com/DrRobertWhitfield Linkedin: https://www.linkedin.com/in/dr-robert-whitfield-md-50775b10/ X: https://x.com/rob_whitfieldmd Read this article - https://www.breastcancer.org/treatment/surgery/breast-reconstruction/types/implant-reconstruction/illness/breast-implant-illness Shop: https://drrobssolutions.com SHARP: https://www.harp.health NVISN Labs - https://nvisnlabs.com/ Get access to Dr. Rob's Favorite Products below: Danger Coffee - Use our link for mold free coffee - https://dangercoffee.com/pages/mold-free-coffee?ref=ztvhyjg JASPR Air Purifier - Use code DRROB for the Jaspr Air Purifier - https://jaspr.co/ Echo Water - Get high quality water with our code DRROB10 - https://echowater.com/ BallancerPro - Use code DRROBVIP for the world's leader in lymphatic drainage technology - https://ballancerpro.com Ultrahuman - Use code WHITFIELD10 for the most accurate wearable - https://www.ultrahuman.com/ring/buy/us/?affiliateCode=drwhitfield

True transformation doesn't come from motivation. It comes from rewiring your mind, reshaping your beliefs, and mastering your perception of reality. This episode reveals how to stop chasing short bursts of inspiration and start creating sustainable change in your thoughts, energy, and biology. You'll learn how belief, emotion, and neuroplasticity shape human performance, longevity, and resilience—and how to reprogram them for lasting results. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with David Bayer, one of the greatest personal growth teachers of our time. His podcast A Changed Mind reaches over 1 million listeners each month, and his event Powerful Living Experience Live was named a top 3 personal development event by Inc. Magazine. His book A Changed Mind has transformed tens of thousands of lives. David blends behavioral psychology, neuroscience, metaphysics, and consciousness theory into practical frameworks that help people rewire their brains and reengineer their reality. He is an entrepreneur, business strategist, keynote speaker, and mentor to some of the world's most influential entrepreneurs and creators. Together, Dave and David explore how motivation is just a microdose of transformation and why true change requires aligning your perception with how reality actually works. They break down the science behind belief, energy, and consciousness, connecting these ideas with biohacking, supplements, functional medicine, and brain optimization. You'll Learn:• Why motivation is only a temporary fuel and how to create lasting transformation• How to test your beliefs against reality and rewire the mind through awareness• The difference between absolute truth and personal truth in consciousness work• Why suffering and challenge are essential for growth and resilience• How to build faith as a biological and psychological muscle• How early trauma programs limiting beliefs and emotional patterns• The four layers of resistance that block personal transformation• Why forgiveness and self-love are essential to dissolving trauma• How perception literally shapes your experience of reality• Practical tools to align your consciousness for high performance and peace Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: David Bayer, A Changed Mind, Powerful Living Experience, belief systems, consciousness theory, neuroscience, behavioral psychology, personal growth, trauma transformation, resilience training, perception shift, motivation vs transformation, emotional regulation, mindset reprogramming, subconscious rewiring, neurohacking, cognitive performance, spiritual psychology, reengineering reality, high-performance mindset, sustainable change Thank you to our sponsors! -GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what's in your air. -Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body's really doing behind the surface. -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -LMNT | Get a free 8-count Sample Pack of LMNT with any drink mix purchase by going to https://drinklmnt.com/DAVE. Resources: • Learn more about David's work: www.davidbayer.com • Order David's book: https://www.amazon.com/Changed-Mind-Beyond-Awareness-Extraordinary/dp/1642939862 • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:25 - Why Motivation Isn't Sustainable 5:14 - Testing Reality as a Hypothesis 9:02 - Absolute Truth vs Personal Truth 11:02 - The Role of Suffering in Growth 15:01 - Building Faith as a Muscle 18:27 - Higher Power & Placebo Effect 20:38 - Believing Without Limits 24:27 - Transforming Childhood Trauma 27:34 - The Four Layers of Resistance 28:58 - Resentment & Forgiveness 33:09 - Turn the Other Cheek 39:28 - Entrepreneurs & Self-Sabotage 43:59 - Building Resilience in Business 46:00 - Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

On today's episode, I'm speaking with biohacker and Bulletproof founder Dave Asprey about the latest in health optimization, longevity, and body hacking. Dave shares his personal journey from building Bulletproof to creating Upgrade Labs, and the science-backed strategies he uses to upgrade his body, brain, and overall performance. We dive into the rise of Ozempic and other metabolic tools, how sleep, light exposure, and circadian rhythms impact testosterone and recovery, and the role of diet, supplements, and peptides in promoting longevity. Dave also explores emotional regulation, stress management, and practical biohacks for boosting energy, improving cognitive function, and living a longer, healthier life. Honest, insightful, and full of actionable advice, this conversation is a must-listen for anyone looking to optimize their health and unlock the power of biohacking. Enjoy!To check out Dave's Website, click HERE.To listen to Dave's Podcast, Human Upgrade, click HERE.To connect with Dave on Instagram, click HERE.To read Dave's new book, Heavily Meditated, click HERE.To connect with Siff on Instagram, click HERE.To connect with Siff on Tiktok, click HERE.To learn more about Arrae, click HERE. To check out Siff's LTK, click HERE.To check out Siff's Amazon StoreFront, click HERE. This episode may contain paid endorsements and advertisements for products and services. Individuals on the show may have a direct, or indirect financial interest in products, or services referred to in this episode.Go to curology.com/dreambigger to get your first bottle of DayPrime for FREE when you subscribe, all you need to pay is $5.45 shipping and handling.Go to quince.com/dreambigger for free shipping on your order and 365-day returns. Go to getcanopy.co to save $25 on your Canopy Humidifier purchase today with Canopy's filter subscription. And look for other Canopy products such as the Canopy Bath and Shower Filter. Even better, use code DREAMBIGGER at checkout to save an additional 10% off your Canopy purchase. Your skin will thank you!Book an appointment today at bit.ly/asktia-dream shopify.com/dreambiggerThousands have already trusted Rula to support them on their journey toward improved mental health and overall well-being. Head on over to Rula.com/dreambigger to get started today. After you sign up they ask you where you heard about them. PLEASE support our show and tell them our show sent you. Go to Rula.com/dreambigger and take the first step towards better mental health today. You deserve quality care from someone who cares.Produced by Dear MediaSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this illuminating conversation of Be It Till You See It, aesthetic nurse and biohacker Rachel Varga joins Lesley Logan to discuss how to achieve lasting radiance by aligning health, mindset, and beauty. She shares how lowering inflammation, managing stress, and purifying your environment can help you look and feel your best—proving that confidence and feeling at peace are the real anti-aging secrets.If you have any questions about this episode or want to get some of the resources we mentioned, head over to LesleyLogan.co/podcast https://lesleylogan.co/podcast/. If you have any comments or questions about the Be It pod shoot us a message at beit@lesleylogan.co mailto:beit@lesleylogan.co. And as always, if you're enjoying the show please share it with someone who you think would enjoy it as well. It is your continued support that will help us continue to help others. Thank you so much! Never miss another show by subscribing at LesleyLogan.co/subscribe https://lesleylogan.co/podcast/#follow-subscribe-free.In this episode you will learn about:How Rachel's nursing career evolved into a holistic approach to beauty and biohacking.The science behind lowering inflammation to boost vitality and radiance.Why redefining vanity as self-respect empowers confidence and self-care.Everyday habits that support graceful aging through stress management and sleep.How cultivating peace and integrity supports inner and outer radiance.Episode References/Links:The School of Radiance Website - theschoolofradiance.comPromo Code: LesleyLogan15 for 15% off one-on-one sessions, tutorial, and membershipSchool of Radiance Podcast - https://www.theschoolofradiance.com/podcastsInstagram: @RachelVargaOfficial - https://www.instagram.com/rachelvargaofficialGuest Bio:Rachel Varga, BSN, RN, CANS, is a Double Board Certified Aesthetic Nurse Specialist. Since 2011, Rachel has been offering medical aesthetic rejuvenation in the specialty of Oculoplastics and is known for providing a natural and healthy-looking transformation and educating through her show "The School of Radiance" podcast. She has performed over 20,000 rejuvenation procedures and is also a trainer for other practitioners on rejuvenation procedures including medical grade skin care, laser skin rejuvenation, injectables including neuromodulators and dermal fillers, and slowing aging in general. Rachel is passionate about delivering the highest standard of care, with a focus on what the patient's specific rejuvenation goals are, and a tailored approach to suit their needs, values, and lifestyle. She has published multiple research articles on rejuvenation protocols for the eyelids, jawline, and overall skin health transformation. Rachel is known for her gentle touch, natural-looking results, and making her patients feel comfortable, and at ease with her caring bedside manner that originated in pediatric nursing before beginning her career in medical aesthetics in 2011. She will guide you in creating your customized rejuvenation plan and skincare routine to achieve your goals through one-on-one sessions, expert 7-week seasonal skincare tutorials, and year-long membership for the deeper layers of being beautifully radiant at TheSchoolofRadiance.com. Rachel Varga is one of the first to blend Western approaches to skin care and rejuvenation, functional insights, and biohacking optimization strategies. By blending the best of these worlds and observing what her most radiant patients are doing she will also help guide you on your path to healthy skin and vibrancy for many years… If you enjoyed this episode, make sure and give us a five star rating and leave us a review on iTunes, Podcast Addict, Podchaser or Castbox. https://lovethepodcast.com/BITYSIDEALS! DEALS! DEALS! DEALS! https://onlinepilatesclasses.com/memberships/perks/#equipmentCheck out all our Preferred Vendors & Special Deals from Clair Sparrow, Sensate, Lyfefuel BeeKeeper's Naturals, Sauna Space, HigherDose, AG1 and ToeSox https://onlinepilatesclasses.com/memberships/perks/#equipmentBe in the know with all the workshops at OPC https://workshops.onlinepilatesclasses.com/lp-workshop-waitlistBe It Till You See It Podcast Survey https://pod.lesleylogan.co/be-it-podcasts-surveyBe a part of Lesley's Pilates Mentorship https://lesleylogan.co/elevate/FREE Ditching Busy Webinar https://ditchingbusy.com/Resources:Watch the Be It Till You See It podcast on YouTube! https://www.youtube.com/channel/UCq08HES7xLMvVa3Fy5DR8-gLesley Logan website https://lesleylogan.co/Be It Till You See It Podcast https://lesleylogan.co/podcast/Online Pilates Classes by Lesley Logan https://onlinepilatesclasses.com/Online Pilates Classes by Lesley Logan on YouTube https://www.youtube.com/channel/UCjogqXLnfyhS5VlU4rdzlnQProfitable Pilates https://profitablepilates.com/about/Follow Us on Social Media:Instagram https://www.instagram.com/lesley.logan/The Be It Till You See It Podcast YouTube channel https://www.youtube.com/channel/UCq08HES7xLMvVa3Fy5DR8-gFacebook https://www.facebook.com/llogan.pilatesLinkedIn https://www.linkedin.com/in/lesley-logan/The OPC YouTube Channel https://www.youtube.com/@OnlinePilatesClasses Episode Transcript:Rachel Varga 0:00  I take this approach of longer lasting beauty through biohacking, because when we reduce inflammation and toxins on all fronts, we then set our body up for success, for being our most radiant versions. And the more radiant we are, the more high vibe we are, the more we can get what we desire out of life, in both our personal and professional lives, and be great people, because our bodies are operating properly.Lesley Logan 0:32  Welcome to the Be It Till You See It podcast where we talk about taking messy action, knowing that perfect is boring. I'm Lesley Logan, Pilates instructor and fitness business coach. I've trained thousands of people around the world and the number one thing I see stopping people from achieving anything is self-doubt. My friends, action brings clarity and it's the antidote to fear. Each week, my guest will bring bold, executable, intrinsic and targeted steps that you can use to put yourself first and Be It Till You See It. It's a practice, not a perfect. Let's get started. Lesley Logan 1:11  Hi, Be It babe. Okay, this is gonna be a really fun conversation. I wanted to have this conversation for a while, and it's really like, I'm intrigued by all this, right? I want to, I want to actually look and feel good for as long as possible, but not in like, a crazy, like, change how I look dramatic way, but like, as in a no, this is like, I want to look like me. And so when I met our guest today, because I was on her amazing podcast, Rachel Varga, she's the host of the School of Radiance, and I was like, oh, I vibe with this person. I really like what they're saying. It's intelligent. It's from a place of research and science and methodologies, and she is so knowledgeable about biohacking and things we can do when it comes to med spas and what we're doing with to support ourselves and how we feel and how we look, and then we go on a wide range of topics. We don't hit everything I want to talk about, so I'm going to have to do this again. But I really think you're going to, one, learn a ton and have a lot of permission get granted, because maybe it's not something you have to do to you, maybe it's something you would get to do around you, or maybe it's about changing something in your environment, right? So now I'm going to let Rachel Varga give you all of her amazing wisdom. Lesley Logan 2:26  All right, Be It babe, this conversation is one I've been really wanting to have, but it had to be with a special person, and so I've been waiting the 500 plus episodes to find the person who we can have a conversation about radiance and how we how our how we can age the way we want to, and look good doing it without feeling like we're being vain or going too far. And so Rachel Varga is our guest today. Rachel, can you tell, can you tell everyone who you are and what you rock at? Rachel Varga 2:51  Yes, Lesley, so great to be here, and we had a fantastic interview on my show recently, the School of Radiance podcast. And, so technically, I'm a nurse, and I've been an esthetics nurse since 2011 so I've been in the game for the rejuvenation side of things for a while. Been in that game, published research papers. You can look my name up on PubMed, Rachel Varga, you'll see my eye rejuvenation papers, jawline rejuvenation papers. And then I also teach other doctors and nurses internationally how to do rejuvenation from the non surgical side of things that like injectables. And I know we're going to talk a little bit about that, what we can do that's cleaner options, what's actually going to work and give us the results that we desire. And so I love to teach, and I love to talk about what we can actually do at home. So on this podcast, we'll talk about the lifestyle side of things, and kind of delineate what we can do at home and then what's available in the clinic. But I take this approach of longer lasting beauty through biohacking, because when we reduce inflammation and toxins on all fronts, we then set our body up for success, for being our most radiant versions. And the more radiant we are, the more high vibe we are, the more we can get what we desire out of life, in both our personal and professional lives, and be great people, because our bodies are operating properly.Lesley Logan 4:23  I love this because I love that you can they it's almost like a there's a few different prongs. So if you're someone who's like, I don't want to do surgery, I don't want to do the injectables like people start to look like cat ladies at some point. And I'm sure that's not all injectables do that. I'm sure there's a point which one could stop. But the idea that we there's things we could do at home, it sounds why wouldn't you, like, Why? Why wouldn't you want to do something at home? So before we get into that, though, I do want to kind of know, like, did you always want to get into esthetics? Was this something that you could wear, like, interested as a kid? Like, were you doing makeup? Like, how? Like, what was the journey that got you here?Rachel Varga 4:59  Yeah. Okay, well, practically speaking, my mom's an RN, and I saw how hard she worked, but I also saw that it was a great job. It's a great way to be in that nurturing, supportive, healthy role in the family. It's like something happens to the kiddos, like you know what's going on, or your partner or yourself. It's just great knowledge to have from a nursing perspective for yourself and those you love. My father's are carpenter and so I always had this eye for, oh, that bumper is a little not so straight, or that picture is a little canted. So I had this eye for symmetry and proportions from that, and then also the health side of things. But I saw my mother really struggle as a night nurse. And she did night nursing, so shift work, it's just brutal in extended care for her pretty well entire career, she got breast cancer. She was, at one point, weighed 220 pounds. So she was the type of woman, great woman over gave, did the shift work. So I learned early in my career that I didn't want to be that kind of nurse. And did Pediatric Nursing, pediatric ICU care for a couple years. And during that time in my nursing education, I'd had a few rejuvenation procedures myself too, both surgically and non surgically, and to myself, the aftercare information like the pre post care wasn't great, and for me, going through nursing training, I was obviously watching all the vlogs online. There aren't really a lot of professionals actually talking about this stuff, and I think it's kind of interesting, and people want to know how to get the most out of what they're investing in in the clinic, and, of course, at home, and how to recover before and after non surgical or non surgical rejuvenation options. And thought I wanted to be a doctor. So did all the med school prerequisites, chem, Organic Chem, biochem. And while I was doing prerequisites and applying to med school, which I did for one year, I got a job as an esthetics nurse, did my injectable training, started in ocular plastics in 2011 and just loved the field. I loved the pace. The hours were great, and I would get access to anything and everything. Then something happened. I met my good friend Dave Asprey. Actually helped get his face ready for superhuman so when you look at that book cover, that's my work. Oh, what's this biohacking stuff? This is pretty cool. Started to do some of it myself, cold plunging, intermittent fasting, more protein, adding antioxidants, amino acids, all sorts of great stuff that's in the biohacking world, red light therapy. And then I was in two car crashes. I had to really lean into the biohacking and recovery side of things and supplementation so that I wasn't hurting all the time, and so that I would recover faster. And partner has been a pro athlete as well, so very in tune with the athletic recovery side of things too. Then something interesting happened. The better I cared for myself from an inflammation perspective, I didn't need as much rejuvenation. Scars were fading after just a couple of days post breakout, instead of for months, and I'd have to laser that redness away. I didn't need to do neuromodulators every three months, I would actually go anywhere from like, a year to a year and a half in between.Lesley Logan 8:45  For the people who are like, what's a neuromodulator,Rachel Varga 8:49  The brand names that you probably know about are Botox, Xeomin, Dysport, Nuceiva, Jeuveau. There's always new ones growing up. So the technical term for those is neuromodulators. And then I also started to notice, oh, wow, I'm not burning in the sun in 10 minutes anymore. These deoxidants, this reducing inflammation, is actually allowing me to go outside and enjoy my life more. And I as a researcher, put together a paper for the biohacking community a couple years ago. What are some of the biohacks that actually can support slowing aging in sort of like a methodical framework, kind of way, because there's so many bright, shiny objects in the in the biohacking and wellness space, like, what actually should we start with?Lesley Logan 9:42  This is insane. So this journey that you went on, like, first of all, you met the person. Like, yeah, you were like, you just met them. And then you needed what they had. Like, thank goodness you met them, because you put, who knows how long would have taken you to stumble upon biohacking in that way. And then it got you to see how it worked on the things that you already do. I can it's interesting to me because, like, I think some people in your field would be like, what is the need for me if I could just biohack my way to blemish-free skin that can be out in the sun, you know what I mean. But obviously, like, there's, there's kind of a place for everything. You know, there's also like, what works for you and what helps with what you need. And so I love the idea for those at home who are like, well, what are some like, what are like? Maybe they could Google what an antioxidant is. But like, what are some things that they should be thinking about when it comes to inflammation and things that can affect how they look? Because I think sometimes people go, Oh, I'm just older. And we were taught like, Oh, you're 40, so now you're 50. Like, these things happen. But from what I understand in biohacking, you can actually do a whole lot. It's not about the age, it's kind of about what you're eating and what you're doing.Rachel Varga 10:54  Yeah, you could actually test instead of guess what your biological age is. And I do this usually about once a year, and my biological age, last time I tested it was nine years younger than my chronological age. So doing something right. Lesley Logan 11:11  I love that. Rachel Varga 11:14  When I started to speak on the anti aging, the functional, integrative and wellness sides of things, being an aesthetic nurse, like a traditionally trained nurse, and then in the specialty of aesthetic medicine, I was kind of the odd one out, a little bit misunderstood, especially in the rare community that I'm in, people didn't really get it. It's more like a California and Florida kind of thing, where people in there, in those states in particular, really big into anti aging medicine, and so that was a bit tough for me. But you know what, some of us were just pioneers in the space. And Dave is more of a disruptor, and I'm more of like an encourager. If I can do it, you can do it too. Lesley Logan 11:59  Yeah. And I think, like, you know, the I, what a great place where you can go, okay, here are your options. We can do these things, and here's how often you'd have to do them, and we can absolutely do them, or we can do this thing, and then this is how often, or you could also do this at home. And then it would make whatever we're doing here would support that, or it would reduce your need for that, is that what I'm hearing, like, the biohacking, like, really supports what you do?Rachel Varga 12:26  Bingo. So for me to speak on things, because I am a traditionally trained RN, I have to be able to speak on things that are published in the literature. There wasn't really anything, and I knew this worked. I would see it in my before and after photos. See, you know, 70 to 90 year olds looking fantastic, and they barely need anything. They were aging better. So the jawline paper that I wrote, I basically put in that paper an algorithm for rejuvenation, starting with skin care, then getting into maybe at home peels and at home dermarolling, doing some in-clinic lasers for reds, browns and collagen, you know, resurfacing pore size, polishing the skin, and then the non surgical injectables. So say you guys all probably hear the word Botox, so neuromodulators and fillers and then surgery. So to start from a space of least invasive, you know, do some things, see if you're happy with those results, you might not need the surgery, but surgery definitely does have a place, coming from ocular plastic surgery for the eyelids. And so I wrote a paper on that, basically an algorithm do least invasive to most invasive, and then the Oxidative Stress Status and Its Impacts on Skin Aging paper that was more like a framework of what's the lifestyle stuff that we can do to actually clean up and purify our environment by purifying our air, water, lighting, electromagnetics, testing, instead of guessing the foods that we're eating and then getting into detoxing. And when you do all those things, you should actually be able to get better results from your treatments. And if you go on message boards for people that have issues after injectables or lasers, chances are there was a degree of autoimmune conditions running in the background, or their toxic bucket was really full. They had rejuvenation bucket tipped over, and they had a manifestation of some underlying things that were happening. And then also, during the process of writing those papers, I came across some data. This is why it's not a nice to do. It's a need to do, to look after yourself, that autoimmune conditions, or, more precisely, deaths of unknown causes, which I reached back to the source of you know, what does this category actually mean, autoimmune condition or someone passing away before diagnosis, it actually doubled in 2019 compared to the data six years earlier in Canada, this is Canadian information, and then it doubled again in 2021. So autoimmune stuff for skin is like, eczema, psoriasis, those are typically the skin stuff that we see. Lesley Logan 15:25  It's interesting that you brought that up because it is like, I think people are like, there's so many people with autoimmune it's like, well, now that we know what to test for. The thing about tests, that's the thing, when we it was all, there, it has probably been there for a really long time. The doubling in such a short period of time is scary, but also it, you know, if the tests weren't right arranging or the doctors don't know to test for these things. But I love that you brought that. I like how you bring that up. It's like if you had stuff run in the background, if you were already inflamed, and then you do something that can add to that, like, it is just like the needle that broke the haystack. And so then the things get the blame when it's a whole host of things that are going on. And so I think this is really cool. You know it's and I don't want to be ignorant, so I think it's really, to me, what I find interesting is that, like, I would never have associated a biohacker with someone who would also be doing any of these treatments. Like I would, you know what I mean? Like, I think people think you're either nothing goes in your body except for these things, or you're, like, whatever, It's a free rein, I can do whatever I want. And so to find someone who sits in the middle, I actually think it gives people a lot more permission. And I actually one of the things I want to talk with you about is, like, just permission, like, I think a lot of people feel bad or feel embarrassed or feel like they shouldn't talk about that they want to make any changes to how they look, because we do live in a place now where, thankfully, people are more accepting and people have been taught to not hate their bodies like we should love our bodies. In fact, your body is listening to you. So part of biohacking would actually be to not talk about the things you don't like about your body because your body's listening. But how can we think about like is it vain for us to want to want to change things on our face, or to want to look a little younger, to want to look a little fresher? Is that? Is that a bad thing? Like, should we not be wanting to change these things? We just be happy with how we look?Rachel Varga 17:11  I think that there's a similarity here with this concept of imposter syndrome. Everyone who starts to do something new is like, Oh my gosh. I don't know of like, Can I do this? Am I gonna get laughed at? I think it's that's just as common as the shadow side of beauty, which is, is this vain? Am I doing something that's selfish to care for myself? One of the reframes that I love to talk about is self-care, self-love. I get so many sweet downloads when I'm doing my skincare, I'm blow drying my hair, I'm doing my beautification, my makeup, putting on a cute outfit, looking at myself in the mirror, it's like, Oh, wow. I had three hours of sleep last night. How the heck do I look this good? Well, there's some biohacks that I did to hack a bad sleep and why I had a bad sleep, which is hilarious. So we can definitely talk about that. But the vanity component is essentially the shadow side of beauty and radiance at its core. So I love to investigate the psychological, the energetic things behind everything as well, because everything is energy. And we're seeing a shift now, though. In about 2018, a number of my clients started to ask me, Rachel, what can I do for healthier skin I want to improve my skin health. So I really started to notice the shift. And then now fast forward to the year that we are in now, every med spa, well, the ones that are, you know, up with the current times, are doing things like NAD infusions, they're offering weight loss, they're offering hormone support, and all of these different things that we're now seeing a really exciting time in the med spa industry, the functional space, integrative and biohacking space, coming together. It's almost like this bifurcation point a couple years ago, but I did see the writings on the wall back in about 2018 that this was going to happen, and now this is what the most notable med spas in the world are doing, is they're incorporating all these things because people want to go to a one-stop shop and not necessarily just look at rejuvenation as being vain, but a form of self-care. They're doing other things as well that they're investing time and energy in, or they might have a health spending account that makes them feel better, because when you feel better, you look better, and when you look better, you feel better. So what I like to suggest, if someone is really grappling with, okay, money's tight or I feel vain about doing this, feel like that money should go to my kids or whatever. But if something's bothering you for a while, say, for example, lines between the brows, or lines to the forehead, or hooded upper eyelids, lower eye bags, melasma, pigmentation, red acne scars, large pores, acne scarring, losing sharpness to the jaw, lines, jowls, fullness to the neck, the list goes on. But if something is really bothering you and you're looking at yourself in the mirror, be like, I really love to do something about that, because it's the one thing that kind of bugs me. I think that the benefit of knowing that, hey, there are some really great health non surgical, or surgical things that we can do to actually support those things. But my angle is, okay, what's the least toxic thing that we can do to give the best results? What is going to give the most long term benefits? So that's why sometimes surgery, like eyelid surgery, is one of the most common surgeries performed to remove excess eyelid tissue. That's actually probably even going to cost less money than trying to do all these other non surgical things, and you have a longer result. So it just depends on everybody's situation. But the vanity thing is something I think every single person grapples with, if they're completely honest with themselves, and then they do it. They do their rejuvenation, they bump up their at home skincare routine, they purify their environment, like, Oh, I feel better. I'm gonna keep doing this, because it's something I do for myself, kind of like getting your (inaudible) you always feel so much better after you have, you know, fresh highlights or whatever. Lesley Logan 21:36  Yeah, yeah. Well, I think, like, there's a difference between doing something because you think it's going to get you people's reaction from people, and doing something for yourself. You know, I think if you are do making changes to yourself, because for other people, that would be a problem, but if you're doing it for yourself, like you said, you don't like the way your pores are. I have my mom, she has talked about the eyelid surgery, and I saw her recently in person. I was like, Oh, poor thing. I don't know. Can you see? Get like, you know, like, and that's not a vain thing. It's also like a necessity, necessity thing, but also like in being it till you see it, some of these things are taking up so much brain space that they're holding us back from coming out and showing people who we are like, if you're not putting yourself out there because you have a scar or you have you don't like the way something looks, that that does bother me, because it does mean that the world is missing out on what your gift is. You know, there are people that you're the only person who can do what you do, and if you're hiding yourself for whatever reason, then that is a bummer, because those people miss out on it and they end up getting swindled by somebody else. So I, I'm of the place, like, if it's for you and it's going to help you show up as the best version of yourself, like, you know, you really do have to look, look into that. But I also love your approach of, like, what's the least invasive, least toxic, most long lasting. And I think if we, I think if we go with that approach, as opposed to quick fixes, then we all, and that goes for everything, not just even for the things you do with your face.Rachel Varga 23:11  100% Oh, you touched on so many beautiful things. So we're gonna back this, because there's some nuggets here for everybody. What happens when you go into the wild, you know, if you're, if you're anything like me, you're working from home, you're going to the gym, you're going to the grocery store, going to church, you know, some work in social events, but that's kind of what the lifestyle looks like. But when we and sometimes I want speeches, and that's super fun, I get all glammed up when you go out into the wild and you see two kinds of people, you see the one person that I just have my hair and, like, a cute little dancer's button I got my workout outfit on. You would love it. It's, like, very Pilates appropriate. Lesley Logan 23:56  I saw it when you (inaudible) I was like, that's so cute. I need a little shawl for my my one my jumpsuit.Rachel Varga 24:02  Oh and I love my body, and I work hard. I lift weights, work on the flexibility, stability, cardio, strength, all those things. I feel fantastic because it brings me in my body as well. W e're very grounding at the end of the day, when you see that individual that they got a little bit of makeup on, they brush their hair, they don something cute, even if it's a little bun, and they have a smile, and they're bright, and they're connecting. Compared to the other person that's just schlepping it. They got their PJ pants on or their sweat pants, they're not put together at all, and they just look like they legitimately rolled out of bed. It's like, okay, something's going on with that person. Oh, this person's really showing up for themselves. They're, you know, putting effort into their appearance. What that actually communicates when you show the world that you're valuable because you value yourself, that's powerful. And if you're showing the world that you just rolled out of bed, your life's a mess, people aren't actually going to value you in the same way. I know that sounds really brutal, but you will be more valued in your relationships. In the professional space, you'll have better relationships. You'll probably be able to make more money, because there's also research to show that people actually who care for themselves the way that they look, earn higher income. But the cool part here that you touched on for you know, reactions for other people is it for yourself. I've seen that where ladies have come to me and their boyfriends in the waiting room and they say, I want to get my lips done. And their lips are already like fantasy lips, if you know what I mean. And I just say to them, no, that's gonna go. If I do anymore, it's gonna really put your lips out of the ideal ratios that actually creates beautiful lips. So you're not a candidate for this treatment. Obviously, there's some body dysmorphia that can have too. However, when we do rejuvenation in a way that looks natural, feels good for us. You know, the body's just like, yes, I want to do this. But thinking about it for a while, it helps to build confidence. Something very interesting about confidence, actually, is that the more confident we are, the better able we're going to be in showing up and building our community. And community is a deep survival need. We're not meant to go through life on our own. We're not meant to over give. We're meant to be supported and receive from those around us, and obviously have it be reciprocated. But the there's the value component, there's the confidence component, there's the community component as well. So there's a lot of really beautiful things actually, about beauty and what it does to our lives.Lesley Logan 27:00  Yeah, and I do, I find it's like, so I used to work at a studio when I lived in L.A., I'd have to, like, leave the house and obviously, how I run and how I shop at the gym, different things, but anything before 7 a.m. that's what different. But when I would go to my studio, I would get dressed to work, go to work, I would teach the whole thing. When I started working from home, I noticed like, oh, I'm not in front of the camera today, so I would just kind of like, still be in the same clothes I did my walk and my workout in, and I was like, starting to slowly feel down about myself and having to give myself more pep talks. And I was doing my fake eyelashes, and they kept getting bigger and wrong, and I kept giving them feedback. And I was like, I don't really like how this is looking. So then I got rid of the fake eyelashes, and now I'm like, well, now I'm a bald eagle, and now I think I'm over at and and I was like, hold on. I also could learn how to do makeup for my natural lashes, and I could get dressed each day, like, how would if I got dressed each day? And what I realized is, by using the clothes in my closet and getting dressed and having a routine of putting my makeup on and and things like that. All those things actually made me feel better. So that whole little haze that, like cloud that was kind of like following around, kind of like an oppression commercial. I don't know if you havethem in Canada, but we have them here, where they're, like, trying to sell you like this cloud that just like hovers over this girl as she walks around, the cloud's gone. I was like, oh, over time, I slowly became used to not doing these things that felt like a waste of time or like not a big deal who's seeing me, and the more I actually spent time with myself. It's not to go back to the vanity topic, It's not vain. It actually just made it easier for me to show up as myself and put myself out there. Because I wasn't going, Oh God, my hair is a mess. Like, like, I, like, got ready for the day, just like, as if I went out into the world to go to work. And so I would say, like, it's really easy for us to go, oh, the world expects us to look a certain way. And really, I actually think the world is quite obsessed with people who are confidently walking in front of them, people who are confidently walking in a room like it. Actually, I'm always amazed, like the people who are famous or infamous and things like that, like some of them, I would never consider like a natural form of beauty, but people are excited about them because they're so calm they walk in, they have their head held high. And so I think if we just go back to like, what are you doing for yourself to help you show up to be the person you want to be, like, those things can't be wrong.Rachel Varga 29:25  Very well said, the, I love this show so much. I love connecting with you, Lesley, I think you're fantastic. You're hitting the nail on the head of, like, really deep topics around beauty and rejuvenation and not enough people are kind of talking about this stuff, the concept of feeling down and self-talk. Let's break that down for a second. A lot of us say, Oh, my fine lines and wrinkles, or, you know, my elevens, or my acne scars, or from an injury perspective, because a lot of you listening are ahletic and sometimes injuries can happen when you're doing new things and pushing your limits and building your strength and your resilience and your readiness and adaptability and all those good things. So instead of saying my whiplash, I detach from it, and I don't say my I say, oh, you know, I'm experiencing this or, Oh, I have a blemish, but I'm not reinforcing it into my identity, because a lot of people have these things that they reinforce into their identity, and then it's like, stuck in their field, if you will. Now we're gonna go just a little bit woo.Lesley Logan 30:39  Oh, you know, we used to only be a one woo show, and considering where the world is right now, Brad and I have gone two woos. We're woo woo in it.Rachel Varga 30:50  Yeah, very much grounded in the 3d science, I published papers. I just the other day, was teaching 60 doctors in Vancouver. Super fun. I just can't help but notice this group of patients that I observed in my career. This is why I talk about radiance, men and women aged 60 to 90 that had never done any rejuvenation. They would come to see me, either on a video call like this, or in the clinic, and I would look at them and be like, Wow, you look fantastic. Like, yeah, you know a couple of things like, bother me. I'd love to do something about it, but it was just how they carried themselves. So I started to kind of unpack this. What is this? What is this that I'm noticing it's like this inner glow, this inner vibration, and what are the components in their life that are contributing to that, which you can ground to the key determinants of health, which are recognized globally as being important factors to determining how healthy you're probably going to be depending on the environment around you. They had a certain vibe to them. Their skin shown differently. Their voice was different. They were very present. They had a family life, they had a spiritual practice. They had hobbies, they had a community. So I coined this radiance, and then I started to dive into some Ayurvedic texts, and came across the definition of radiance, which I think is one of the best definitions of that word that I've ever come across. It's the electromagnetic projection of all of your body systems. The radiant body is the 10th body, and then we have our body, mind, spirit, energy. There's some other bodies in there, but the radiant body is basically that electromagnetic projection of you and a reflection of how all your operating systems are running into the world. And when you begin to hone and cultivate this radiant energy, it's kind of like you become a queen, and you enter a room and everybody notices you for all the right reasons, you become a magnet. And with that, when you step into that very powerful, radiant, queen, feminine and (inaudible) energy, you also repel vibes of certain people that aren't going to be in your highest it's like you're a magnet, but you're also very attractive.Lesley Logan 33:22  Yeah, just like magnets also repel the other side. Rachel Varga 33:25  Exactly. Yes. So magnetic to the right people, the right situations, the right opportunities, and telling yourself (inaudible) oh, you know, there's great things coming just around the corner that are better than I even imagined. And I say that all the time, and it happens all the time. So this becomes you. You become like this force. And one of the most cool things about this as a woman is you get respected, and you are revered by men, not just idolized for looking a certain way, but actually respected and revered, and this is getting into some of the more powerful layers of beauty and radiance. And what you mentioned with your self talk, you probably felt some guilt and shame, right? And those are the lowest vibrations we can possibly sit in. The highest ones are peace love, joy, then there's pre enlightenment, then there's enlightenment. So peace, love, joy, channel your inner (inaudible) that is actually setting the stage for all of your cells and inner machinery and operating systems and field, the human biofield, is an emerging body of science to shine brighter, to slow aging, to feel better, to look better.Lesley Logan 34:47  I love this, and I really do believe in it, because there was years ago I listened to a podcast where they said your cells are listening to you, and how you talk about yourself is what you produce. So if you, going back to your like, my scars, my this, it's so important that you do, you don't hold on to those things, because the body is listening and like they actually did some scientific studies, multiple ones. One of them was they took these people, they blindfolded them, they set them in a chair. They were in a room where they could hear a fire burning, right? And they could hear this hot and they could hear like this, when you put, like, water goes right, that whole thing. And they're like, okay, we're gonna take this (inaudible) and we're gonna brand you, right? And these people are like, Oh my God, they're telling, they're describing what the branding mark is going to be. All these things. I don't even know how they clear this, because it sounds like trauma and torture and all the things, however they did it. And what they would do is they would like make the sound, and then they touch the person with a pen, a pen, and the person develop the welt in the shape of the description of what the branding was going to be. Right? Like, now, whether it lasts or not, wasn't part of the thing, but like they the body was like, so prepared for what it was told it was going to become. And another doctor was trying to figure out if it was a scraping of the knee or the drain of the knee that actually was healing these knee issues. So of course, he has to take three groups of people, one where nothing happens, one where they scrape and one where they drain, and then compare the three and the people who had nothing they were just put into they were put under anesthesia. They played, they played a video of a knee surgery happening so that they would hear in their subconscious they were sent to do all the same post surgical protocol as everyone else. They had the same results as the people who had had surgery, because they told themselves, I had surgery, my knee is fixed, and their body did these things. And so I became so conscious of like, what are we actually talking to ourselves about? Because before we go into all the things we could do to change our bodies, before we go into the biohacking foods, and then what type of treatments we could do, how you're talking to yourself, is literally free. It's a, it's a, it's a free thing you can change. It costs nothing.Rachel Varga 37:01  when you think of a monk, what are they doing all the time? Lesley Logan 37:03  Oh, we get to see them in Cambodia all the time. They are meditating and they're praying. They give blessings. That's what they're doing, just sitting there meditating.Rachel Varga 37:15  And you said something very profound, giving. Lesley Logan 37:19  Blessings. Rachel Varga 37:23  Who you are, depending on what really your reason is for being here. For mine, it's really to activate and initiate men and women around me to be their best versions. I'm very clear on that. So for me and my presence, that's how I serve. That's how I offer. It's how can we be in this state where we engage with others and we brighten their day, we say something kind to them, the way that we move through life is like an offering and a blessing. We first need to fill our cup first, though, that's very important. One of the things that you can channel next time you're in your Pilates or a heavy lifting situation, I do this all the time at the gym. I actually do breath work because for activity as women, especially if you're around that pre perimenopausal, perimenopausal, menopausal and postmenopausal, the body's going through transmissions, and what breaks down collagen and elastin quickly is elevated cortisol, which results in a drop of estrogen. When estrogen falls, collagen, elastin, fall too the more at peace you are, the more in that parasympathetic state you are, the less you're in the sympathetic state with high cortisol, adrenaline, you're going to age slower. You're going to have a slowness of the collagen elastic breakdown. And you could actually just do things to stimulate it, right? Like good skincare, sunscreen on the high real estate areas, mineral only at home, dermarolling, in clinic, lasers to get that collagen back up. Consuming collagen is also great. 10 to 12 grams a day is what's in the literature to actually create those visible skin changes in a month. But what I do when I work out is something hilarious, and I actually did bench press with the bodybuilder gym (inaudible) crew at the gym. I was included. They respect me. They revere me. They see my dedication and hard work. So, you know, I was right there with them get it spotted and encouraged, and here I am elevating their presence as well. But when I work out, and I was actually sharing this with one of the bodybuilders, because they'll do like smelling salts to get them in the sympathetic state, which could be good for the masculine, but for the feminine, we don't want that. We want to keep that cortisol down, what I do, actually, between sets of working out, is go right into parasympathetic breathing. Breathe in for four seconds, hold it for four seconds, exhale for four seconds. And you can do this, do like four to five cycles of that. You can drop into that at any point during the day when you get some news of a task that you need to do. I run like 13 businesses. So there's always, you know, these kind of small fires, and I have to figure out, like, who to delegate what I need to do, blah, blah, blah. But there's always something. So no matter what, I just always drop into that. Have those dates, have that honey, so I have that glycogen. Take those adaptogens to support the adrenals. Do the self care. But the biggest thing, I think, for beauty and slowing aging is, what do you think creates peace?Lesley Logan 41:05  What do I think creates peace? In someone's life?Rachel Varga 41:07  Yeah, what do you think creates peace in someone's life? Lesley Logan 41:10  Oh, my gosh. Well, I don't, to be honest, my mind is (inaudible) a few places. One, good sleep, that helps with peace. Two, not taking things personally, that could take, I think that could cover a lot of things. Maybe the whole four agreements would create peace and then self love.Rachel Varga 41:29  That's beautiful. What actually builds our confidence when you make a decision and we're happy with those decisions that we're making, or making them out of integrity. People who make really bad decisions, they have to live with guilt and shame, and they have terrible sleep. They're tossing and turning, and they got night sweats. All sorts of stuff goes on in someone's nervous system when they constantly have that guilt and shame, operating in the background. Ask for forgiveness, but move towards operating in integrity in every single thing that you do, you will have more peace because you're making better decisions. I wouldn't I can't picture a monk acting out of integrity, right? That's like against their code. So to have that, I just think it's gorgeous. Not taking things personally is also great. So you're recognizing that not everybody is taking as good care of you. You might have different values or lifestyles or what's important to you. So not taking things personally and just kind of witnessing that everyone's on their own journey, and just let go, but just have that knowing that the decisions you're making are out of integrity, and self love is such a beautiful component to that as well because you're telling your body when you're doing your skincare in the am and pm, you're washing your face, you're putting great things on that aren't toxic, and you're doing a lot of the personal development stuff as well, to be the best human that you can be, to be the best woman partner that success in your career, and just be a light in the world and think that and bring beauty. Literally, I've done this. I've just had a terrible day, something's going on, and I put on a cute outfit, do my hair and makeup, and I go engage with someone. They're like, Wow, you look so pretty today. It was like, it brightens my day. My beauty brightened their day. And then send and receive. I give them a compliment of something that I see is beautiful in them, too.Lesley Logan 43:35  Yeah, oh my gosh. You know, so many good things. And there was like five, five other things I wanted to get to in today's episodes. We're just gonna have to have you back. We're just gonna have to have you back because I was like, really hoping we could talk about, like, is Gua Sha really working? What are the things I should be doing? So we're just gonna have to do this again, and we're gonna take a brief break and find out how people can find you, follow you, work with you. And you already gave us some good stuff, but some Be It Action Items. Lesley Logan 43:58  All right, Rachel, where do they hang out? Where do you hang out? Where can people like stalk you in the best way, get more information, work with you, talk with you, where can we send them?Rachel Varga 44:08  Absolutely, I hang out on Instagram. I love to engage with those who are you? They say yes to themselves. They know they're worth it, and they're curious about some of the different options I share a ton of very entertaining education, like, I shared some sleep stuff like, why (inaudible) sleeps because I took creatine too late after my workout. But how did I hack that not so great sleep? I took a little bit more in the next day because it fires up your ATP, anyways, funny stuff like that. As a biohacker and also in the med spa space is over @RachelVargaOfficial, that's my Instagram handle. And then the podcast, really great show, the School of Radiance podcast. And then theschoolofradiance.com is my website, where you can book a one-on-one. You can join my seasonal skin tutorials, where I actually show you how to do Gua Sha, do your skincare, your makeup, your dermarolling peels, retinols, what rejuvenation is great to do that time of year, so basic and advanced stuff over six weeks, great. Not a YouTube tutorial. It's way better. Lesley Logan 45:13  I'm already in. I'm like, hold on, I need to. Rachel Varga 45:15  Super fun, super fun, right? And then the membership is more of that high level. How do we actually activate this radiance and stuff so we can enjoy our lives better and make more money in the process? Those are the two key metrics you're gonna get benefits from.Lesley Logan 45:30  Amazing. You guys, we have a promo code for you in the show notes and everything, so make sure that you check that out. I already have an appointment booked because I am really excited. And it's, again, not because of it's like, oh, I'm trying to be vain. I'm trying to be something that the world wants. No, it's so that when I look in the mirror, I feel awesome about myself, and I can show up more and more and do all the things. And so I'm just so grateful that our paths crossed. You have given us a lot of great tips. Ladies, get on the creatine. Okay, it's really amazing. There's tons of research. Oh yeah, muscles also, just like, apparently, tons of work on the Alzheimer space, which I'm very excited about. Thank God I've been doing creatine for years. But bold, executable, intrinsic or targeted steps our listeners can take to be it till they see it. What do you have for us? Rachel Varga 46:16  Yeah, the skincare checklist, actually, over at theschoolofradiance.com when you sign up for my newsletter, I have a free 30 minute biohacking lesson too, and use promo code LesleyLogan15 for 15% off of your one-on-one here with m. Creatine, creatine, creatine, yes, high protein, one gram to 1.5 grams of protein per pound of body weight, huge when I started to lift heavy and do those two things, and keep up with the flexibility, mobility that just gave me more inner power, activation, if you will, great for the skin too, and caring for yourself, not just your skincare, not just your rejuvenation, but purifying your environment, air, water, lighting, electromagnetics, eating the right food, then detoxing is a key part, but it's what we do every single day.Lesley Logan 47:07  I love that you brought those things up, because I do a lot of people go on detox all the time, but they don't fix their don't check their water problem. When I lived in L.A., all the water stuff said the pipes were great. Everything is great. You guys, I had arsenic and cadmium in my system. So how, right? So we had to, like, we lived in a 500 square foot apartment and had, like, a $5,000 water system put in, and yes, I took it with me when we moved. But I think it's really important so that you all can support things. Right? These are things you can do at home, with your for yourself and in your environment to help you feel really good. So I am obsessed with these tips. I really am obsessed with you. I can't wait for more conversations together and how people are going to use these tips in your life. You guys, let us know. Tag Rachel Varga, tag the Be It Pod. Share this with the friend who needs to hear it. Sometimes we have friends who are actually overly picking on themselves, and maybe I actually think the words that we talked about here today can really support that and help them understand like, you know what is needed, what is necessary, what is helpful, and then also, if you're starting to feel a little bit out of it yourself, like I, I'm gonna tell you right now, it's really okay to care about how you want to put your hair or how you want to dress, because those things actually help us show up more in the world. And we're we are allowed to take up space. So Rachel, thank you so, so much. And until next time everyone, Be It Till You See It. Lesley Logan 48:23  That's all I got for this episode of the Be It Till You See It Podcast. One thing that would help both myself and future listeners is for you to rate the show and leave a review and follow or subscribe for free wherever you listen to your podcast. Also, make sure to introduce yourself over at the Be It Pod on Instagram. I would love to know more about you. Share this episode with whoever you think needs to hear it. Help us and others Be It Till You See It. Have an awesome day. Be It Till You See It is a production of The Bloom Podcast Network. If you want to leave us a message or a question that we might read on another episode, you can text us at +1-310-905-5534 or send a DM on Instagram @BeItPod.Brad Crowell 49:06  It's written, filmed, and recorded by your host, Lesley Logan, and me, Brad Crowell.Lesley Logan 49:10  It is transcribed, produced and edited by the epic team at Disenyo.co.Brad Crowell 49:15  Our theme music is by Ali at Apex Production Music and our branding by designer and artist, Gianfranco Cioffi.Lesley Logan 49:22  Special thanks to Melissa Solomon for creating our visuals. Brad Crowell 49:25  Also to Angelina Herico for adding all of our content to our website. And finally to Meridith Root for keeping us all on point and on time.Support this podcast at — https://redcircle.com/be-it-till-you-see-it/donationsAdvertising Inquiries: https://redcircle.com/brandsPrivacy & Opt-Out: https://redcircle.com/privacy

Episode Highlights With DaveWhat led to him writing a book about meditation and what surprised him mostWhy meditation is one of the most impactful tools he uses How he went from learning to put butter in coffee on the side of a mountain in Tibet to the father of biohackingWhat makes this book different from any other books about meditationMeditation as it's typically understood is a waste of time- here's whyFalse: Everyone should meditate more (not necessarily)98% of humans were involved in agriculture for the last few thousand years, and how this matters for the personalization of meditation“ If I can trigger you, it means you are a loaded gun”He's woken up at 5 am to meditate for long periods of time and what he learned from thisTechniques that go beyond meditation to amplify the resultsUnderstanding the actual goal of meditation to get real results and not just waste timeSomatic practices and why these can work most quickly The recipe he uses with top executives called the RESET method, which is a somatic practiceDark is one of the most underrated supplements in the world… here's whyHow to change your state, just with lightHow he and I both experienced absolute darkness in a cave (separately), and what we learned from thisYour body processes reality before you have time to thinkWhat's missing from meditation and psychology teaching and how understanding this can be life-changingResources MentionedHeavily Meditated: The Fast Path to Remove Your Triggers, Dissolve Stress, and Activate Inner Peace by Dave AspreySmarter Not Harder: The Biohacker's Guide to Getting the Body and Mind You Want by Dave Asprey

Discover a little-known Japanese walking technique that outperforms 10,000 steps a day. It boosts fat burning, lowers stress, improves mitochondria, and transforms your metabolism—all in just 15–30 minutes. Perfect for anyone who wants sustainable results without punishment workouts.*Chapters*00:00 – 00:46 My 300 lb journey & the surprising Japanese method00:46 – 01:54 Why mainstream fitness advice fails for fat loss01:54 – 02:37 Walking as the most underrated fat-burning tool02:37 – 04:03 The problem with steps & the Japanese breakthrough04:03 – 05:52 How interval walking works & how to do it05:52 – 09:12 Outdoor hacks that maximize resultsConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Upgrade your biology in 10 minutes with this week's rundown from Dave Asprey. This episode breaks down the six biggest stories in biohacking and health tech, from sleep hormones to mitochondrial rejuvenation, giving you the data you need to live longer, think faster, and perform at your peak. This episode covers: • The Melatonin Heart Warning Everyone Missed A major new study from the American Heart Association reveals that long-term melatonin users face nearly twice the risk of heart failure and 3.5 times higher hospitalization rates. Once considered a harmless sleep aid, melatonin's hormonal effects may disrupt cardiovascular recovery, testosterone, and blood pressure regulation when used nightly. The takeaway: melatonin is a short-term circadian reset tool, not a forever supplement. Source: American Heart Association — newsroom.heart.org/news/long-term-use-of-melatonin-supplements-to-support-sleep-may-have-negative-health-effects • Bryan Johnson's Extreme Microplastics Detox Biohacker Bryan Johnson shared lab-verified results showing an 85% reduction in microplastics in his semen after one year of daily 200°F dry saunas followed by ice packs on the groin. It's not peer reviewed yet, but it'ssparking global discussion about environmental toxins, fertility, and detoxification. Whether or not you follow his protocol, this study highlights how widespread microplastics have become and how heat, sweat, and smarter exposure control may help fight back. Source: New York Post — nypost.com/2025/10/23/health/biohacker-bryan-johnson-got-rid-of-85-of-microplastics-from-his-semen • Urolithin A: The Mitochondrial Molecule That Strengthens Immunity A peer-reviewed human trial published in Nature Aging found that four weeks of daily Urolithin A (Mitopure®) supplementation improved immune function in adults aged 45–70, increasing youthful CD8 T-cells, natural killer cells, and mitochondrial performance inside immune cells. By triggering mitophagy, your body's cleanup process for old mitochondria, Urolithin A enhances energy, resilience, and immune strength. It's the clearest evidence yet that we can modulate immune aging through mitochondrial renewal. Head to timeline.com/dave to get 10% off your first order. Source: BioSpace — biospace.com/press-releases/timeline-continues-to-build-the-most-clinically-researched-longevity-products-targeting-immune-brain-and-muscle-aging • Google's New AI Model That “Talks” to Cells Google DeepMind and Yale launched Cell2Sentence-Scale, an open-source AI model that lets scientists query cellular pathways in natural language. The system can predict how cells transition from healthy to cancerous states and identify molecular switches that might reverse those changes. It's compressing years of biology into days and democratizing research for small labs and independent scientists alike. Isn't AI a beautiful thing? Source: Google DeepMind — blog.google/technology/ai/google-gemma-ai-cancer-therapy-discovery • Omega-3s Calm the Brain and the Temper A massive new meta-analysis of randomized controlled trials shows omega-3 fatty acids (EPA and DHA) reduce aggression by up to 28%. That includes both reactive anger and planned aggression. By lowering neuroinflammation and stabilizing cell membranes, omega-3s appear to balance dopamine and serotonin, proving that healthy fats aren't just heart food, they're emotional regulators too. Source: Science Alert — sciencealert.com/one-dietary-supplement-was-shown-to-reduce-aggression-by-up-to-28 • Chronic Fatigue Syndrome Finally Gets a Biomarker For the first time, researchers have developed a blood test that accurately identifies chronic fatigue syndrome (ME/CFS) using DNA methylation and micro-RNA expression patterns. This breakthrough distinguishes CFS from other autoimmune and viral conditions, marking a turning point for millions of patients long dismissed by traditional medicine. It's proof that data-driven diagnostics can transform how we understand mystery illnesses. Source: Science Daily — sciencedaily.com/releases/2025/11/251102205021.htm All source links provided for easy reference to the original reporting and research above. This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: melatonin heart risk, sleep hormones, microplastics detox, Bryan Johnson, Urolithin A, mitophagy, mitochondrial health, immune aging, DeepMind AI, cellular modeling, omega-3 aggression, neuroinflammation, chronic fatigue biomarker, ME/CFS test, biohacking news, longevity research Thank you to our sponsors! -LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser.-Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Intro 0:18 — Story 1: Melatonin & Heart Health 1:58 — Story 2: Microplastics Detox 3:39 — Story 3: Urolithin A & Immune Function 5:19 — Story 4: AI Cell Model 6:57 — Story 5: Omega-3 & Aggression 8:43 — Story 6: CFS Blood Test 9:59 — Weekly Upgrade Protocol See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Pain isn't just in your body, it's in your brain. In this groundbreaking episode, Host Dave Asprey sits down with Dr. Daniel Amen to reveal how emotional and physical pain share the same neural circuits and how you can rewire them for relief, resilience, and longevity. You'll learn practical tools to break the “doom loop” of pain, restore neuroplasticity, and retrain your brain for calm, healing, and high performance. This is essentiallistening for anyone ready to stop managing pain and start hacking it. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR The Washington Post called Dr. Daniel Amen the most popular psychiatrist in America. He is a former infantry medic and board certified child and adult psychiatrist who trained at the Walter Reed Army Medical Center in Washington, DC. He is the CEO and founder of Amen Clinics, with 11 locations nationwide and home to the world's largest brain imaging database for psychiatry with nearly 300,000 SPECT scans on patients from 155 countries. Dr. Amen is a 12 time New York Times bestselling author, including the books Change Your Brain, Change Your Life, Healing ADD, Memory Rescue, Raising Mentally Strong Kids, and The End of Mental Illness. He has published over 90 scientific articles and led groundbreaking brain imaging research on NFL players, childhood trauma, negativity bias, reversing brain aging, obesity and the brain, and predicting treatment responses. With over 10 million followers and multiple PBS specials, his mission is bold: to end mental illness by creating a revolution in brain health. His newest book Change Your Brain, Change Your Pain explores the neuroscience of pain and how to heal it through brain optimization and functional medicine. Host Dave Asprey and Dr. Amen uncover how suppressed emotions, inflammation, gut health, and mitochondrial function all influence pain and what you can do to reverse it using biohacking, functional medicine, and supplements. They explore how chronic pain rewires neural pathways, how to activate your brain's natural calming switch, and why techniques like hypnosis, red light therapy, rage journaling, and havening can restore balance to your nervous system. You'll also learn the surprising links between aspartame, Tylenol, and generational anxiety, and how to protect your mitochondria to optimize energy, metabolism, and emotional resilience. This episode delivers practical, science based tools for brain optimization, sleep optimization, neuroplasticity, and anti aging while connecting the dots between biohacking, psychology, and functional medicine to help you live smarter not harder. You'll Learn: • How emotional pain and physical pain run on the same brain circuits • Why suppressed rage can trigger chronic pain and how to release it • The link between inflammation, gut health, and brain suffering pathways • How supplements like saffron, curcumin, and omega 3s support pain relief and mood • Why red light therapy, hypnosis, and havening boost neuroplasticity and calm the nervous system • How environmental toxins, aspartame, and Tylenol disrupt mitochondria and increase pain • Simple daily habits to retrain your brain for resilience, optimism, and longevity Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: chronic pain neuroscience, emotional pain circuits, Change Your Brain Change Your Pain, Dr. Daniel Amen, Dave Asprey, biohacking, neuroinflammation, anterior cingulate cortex, SPECT imaging, mitochondrial metabolism, functional psychiatry, neuroplasticity, rage therapy, havening technique, red light therapy, saffron supplements, aspartame toxicity, gut brain axis, trauma healing, pain hacking BrainMD Happy Saffron Plus: Affiliate Link: https://www.awin1.com/cread.php?awinmid=89351&awinaffid=855302&ued=https%3A%2F%2Fbrainmd.co…Dave's 15% OFF Discount Code: DAVE15Please note – works on one-time purchases or the first order of a subscription.Thank you to our sponsors! • AquaTru | Go to https://aquatruwater.com/daveasprey and save $100 on all AquaTru water purifiers. • NeuroVeda Health | Go to https://www.neurovedahealth.com/aspery to learn more and book your week. • BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. • ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Dave's Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated• Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 — Trailer 01:25 — Dr. Amen's Brain Scan Research 02:11 — Physical vs Emotional Pain 05:15 — Childhood Trauma and Pain 08:10 — The Doom Loop Explained 14:01 — Havening Technique 18:27 — Training Positivity and Hope 22:11 — Rage Therapy and Journaling 26:44 — COVID and Brain Inflammation 29:41 — Mitochondria and Energy 36:14 — Pain Relief Protocol 39:32 — Saffron for Pain 43:28 — Aspartame and Anxiety 47:30 — Pain Switches in the Brain 50:50 — Red Light Therapy 52:39 — Fear and Pain Loops 56:36 — Environmental Toxins58:21 — Final ThoughtsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Fan Favorite episode of the Second in Command Podcast, Cameron Herold speaks with Anna Collins, President and COO of Bulletproof, the globally recognized brand behind Bulletproof Coffee, supplements, and biohacking products designed to help people perform better, think faster, and live healthier lives. She is also a Board Member of Ladies Who Launch.Before joining Bulletproof, Anna led multi-billion-dollar businesses at Amazon, Microsoft, and CVS Health, bringing a data-driven, operational mindset to every stage of growth. In this conversation, she reveals how she helped Bulletproof evolve from a niche “biohacker” brand into a household name—streamlining operations, tightening focus, and scaling omnichannel distribution without losing its visionary edge.Anna also shares her leadership principles, from managing a founder with 100 ideas a day to running metrics-driven weekly business reviews that keep innovation grounded in reality. Her insights bridge the gap between entrepreneurial chaos and corporate discipline, showing how great COOs turn vision into execution.Timestamped Highlights[00:00:00] – Cameron introduces this episode as one of the most downloaded in show history.[00:01:14] – Anna's career journey: from Microsoft and Amazon to joining Bulletproof.[00:03:52] – Why she left Amazon Prime for a mission-driven brand.[00:05:36] – What convinced her Bulletproof wasn't just a fad—but a real performance enhancer.[00:06:23] – Partnering with Dave Asprey: defining roles between visionary and operator.[00:07:18] – The challenge of narrowing focus when everything looks like a good idea.[00:08:54] – Bringing Amazon's frameworks—tenets, principles, and data mechanisms—into Bulletproof.[00:10:07] – How structure helped Dave trust the team and delegate.[00:10:26] – Shutting down international markets and cutting SKUs to simplify growth.[00:11:59] – Expanding into Amazon marketplace and corporate distribution channels.[00:13:28] – Convincing the founder to “grow beyond the core biohacker.”[00:17:00] – Managing an idea-rich founder without stifling creativity.[00:18:37] – Anna's leadership philosophy: define reality, create possibility, say thank you.[00:21:00] – Rebuilding Bulletproof's vision, mission, and values for clarity and culture.[00:24:20] – Weekly Business Reviews: the data-driven rhythm behind execution.[00:30:32] – How Anna divides her focus across key stakeholders—customers, team, and growth.[00:36:35] – Simplifying the Bulletproof brand for mainstream accessibility.[00:38:00] – Where she struggles as a leader—and the balance between speed and empathy.[00:42:33] – The advice she'd give her 21-year-old self: don't take it all so seriously.About the GuestAnna Collins is the President and COO of Bulletproof overseeing strategy, operations, and omnichannel growth for the globally recognized biohacking brand. Previously, she led billion-dollar initiatives at Amazon, where she managed global Prime membership programs, and at Microsoft, where she built the search advertising business from concept to $1.6B in revenue. She is also a Board Member of Ladies Who Launch.A Harvard MBA and transformational leader, Anna specializes in building scalable systems that bridge creative vision with operational discipline. At Bulletproof, she's helped expand the company from its core biohacker audience to a broader wellness market—making human optimization accessible to everyone.

This episode is sponsored by Magnesium Breakthrough and Sleep Breakthrough — two of my favourite biohacks for deeper sleep and better recovery. Right now you can get 15 % off either one when you use the code TONY15 at bioptimizers.com/tony   My guest today is genetic expert and epigenetic performance coach Chris Barnes. He delivered a keynote in Australia at Wanderlust Wellspring, alongside the biggest names in longevity such as Wim Hof, Dave Asprey and more.  But what's his daily biohacking routine?  Check out his work here.    THIS SHOW IS BROUGHT TO YOU BY: BiOptimizers Sleep Breakthrough and Magnesium Breakthrough These are BIOptimizers sleep and magnesium supplements which I take every night.  I have also been using the new Magnesium Breakthrough drink - delicious way to get magnesium. I have been putting a scoop in my protein shake after a workout.  Just go to BIOptimizers.com/tony and use code TONY15 for at least 15% off (often more). Code works worldwide, and on all their products.

Your body does not just run on food or supplements. It runs on energy and information. This episode reveals how to harness that energy for faster recovery, stronger mitochondria, and better emotional resilience. You will learn how energy fields, frequency, and information medicine are reshaping the science of human performance, longevity, and anti-aging. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Harry Massey, a British entrepreneur, filmmaker, and visionary in the field of bioenergetics. In his 20s, Harry's health collapsed after a series of physical injuries, viral infections, and emotional trauma left him bedridden for seven years with chronic fatigue syndrome. Conventional medicine could not provide answers, so Harry began studying energy and information as the missing foundations of human health. His discovery of the pioneering research of Australian scientist Peter Fraser led to a breakthrough. Using Fraser's early frequency-imprinted remedies, Harry experienced a dramatic recovery and went on to co-found NES Health, now Energy4Life, to bring this new field of bioenergetics to the world. Backed by published studies at UC San Diego showing a 22 percent increase in mitochondrial efficiency and the activation of more than 1,000 genes for cell resilience, Harry's work unites ancient healing wisdom with modern physics, light therapy, and quantum biology. Together, Dave and Harry explore how bioenergetics, light frequencies, and digital information enhance neuroplasticity, metabolism, and sleep optimization more effectively than supplements or nootropics alone. You will discover how trauma drains energy, how to restore it through the body's natural field communication systems, and how wearable tech and AI are transforming functional medicine. You'll Learn: • How bioenergetic wearables increase mitochondrial energy by 22 percent • Why emotional trauma and energy leaks accelerate aging • How structured water and light frequencies store biological information • The connection between quantum biology, neuroplasticity, and healing • How energy fields regulate longevity, metabolism, and brain optimization • Why AI-powered diagnostics and frequency medicine are the next frontier in biohacking Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: energy healing, bioenergetics, Harry Massey, Dave Asprey, Energy4Life, NES Health, Infoceuticals, GEM wearable, frequency medicine, energy field, quantum biology, mitochondria, neuroplasticity, functional medicine, human performance, longevity, sleep optimization, anti-aging, metabolism, trauma healing, brain optimization, light therapy, structured water, information medicine, UCSD study, Peter Fraser, energy medicine, energy hacking, biohacking, nootropics, supplements, ketosis, fasting, AI, smarter not harder, Danger Coffee **Grab a generous discount from Harry at https://www.e4l.com/Dave. **Thank you to our sponsors! -BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order. -AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers. -Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15• Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 – Trailer 1:25 – Seven Years Bedridden 3:50 – Three Traumatic Events at 21 6:43 – Searching for Answers 9:02 – Meeting Peter Fraser in LA 11:10 – Dave's Skepticism About Homeopathy 17:42 – The GEM Wearable Device 20:29 – Mitochondrial Efficiency Research 27:05 – Body as Signaling Networks 30:49 – Challenging the Chemical Model 35:10 – Biohacking and Ancient Practices 36:15 – Future of Bioenergetics 44:40 – Closing Thoughts on Energy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

What if mastering your metabolism wasn't just about food, fasting, or fitness — but about transforming your inner world? Purchase Dave Asprey's new book Heavily Meditated here: https://amzn.to/3LlrKQ0 In this in-person episode of the Metabolic Freedom Podcast, Ben Azadi sits down with Dave Asprey, the Father of Biohacking, in Austin, Texas, for a powerful conversation that bridges science, spirit, and self-mastery. Together they explore how your mitochondria — the energy-producing engines inside every cell — also shape your emotions, mindset, and ability to heal. Dave shares insights from his new book, Heavily Meditated, revealing how practices like gratitude, forgiveness, and meditation can unlock a deeper level of metabolic and emotional freedom. You'll hear how trauma drains your energy, how fasting and breathwork boost mitochondrial intelligence, and why taking control of your biology starts with mastering your inner state. This episode blends cutting-edge science with timeless wisdom. If you're ready to stop living reactively and start consciously programming your own operating system, this one's for you.

This episode is sponsored by Magnesium Breakthrough and Sleep Breakthrough — two of my favourite biohacks for deeper sleep and better recovery. Right now you can get 15 % off either one when you use the code TONY15 at bioptimizers.com/tony   There are biohacking events happening all over the world right now. And what is emerging is a remarkable template for longevity.    Saudi Arabia and Australia have been two of the notable ones in the last few days, and they're pushing the limits of what's possible for health and human performance. My guest today is genetic expert and epigenetic performance coach Chris Barnes. He delivered a keynote in Australia at Wanderlust Wellspring, alongside the biggest names in longevity such as Wim Hof, Dave Asprey and more.  Check out his work here.    THIS SHOW IS BROUGHT TO YOU BY: BiOptimizers Sleep Breakthrough and Magnesium Breakthrough These are BIOptimizers sleep and magnesium supplements which I take every night.  I have also been using the new Magnesium Breakthrough drink - delicious way to get magnesium. I have been putting a scoop in my protein shake after a workout.  Just go to BIOptimizers.com/tony and use code TONY15 for at least 15% off (often more). Code works worldwide, and on all their products.    

What if getting older had less to do with your birthday and more to do with the health of your cells? Some people in their 50s feel stronger and sharper than ever, while others feel decades older than they are. The difference isn't luck or expensive treatments. In this video, you'll learn what really drives aging, how to measure it, and the surprising practices that can help you feel younger, stronger, and more focused right now.Chapters0:00 – Introduction0:21 – Why aging isn't about time0:49 – Biological age vs chronological age1:40 – Cellular dysfunction and mitochondria3:00 – How weak mitochondria accelerate aging4:00 – Turning on your body's switch6:44 – REHIT workouts to build new mitochondria8:45 – Fueling with fats for clean energy10:05 – Your body's deep clean process13:56 – Fasting methods that support renewal15:58 – The hidden factor: chronic stress19:02 – Stress hacks to unlock longevityConnect with Dave Asprey!Thank you to our sponsor!-MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order.Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Discover how quantum energy, frequency medicine, and consciousness science are rewriting what's possible for human performance and longevity. This episode reveals how your biofield, mitochondria, and brain can be trained, just like your muscles, to achieve higher focus, deeper resilience, and accelerated healing. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Philipp Samor von Holtzendorff-Fehling, founder and CEO of Leela Quantum Tech, about the cutting-edge research proving that quantum energy can neutralize EMF damage, improve neuroplasticity, and activate self-healing at the cellular level. A former telecom executive turned energy researcher, Philipp has led dozens of double-blind, placebo-controlled studies validating measurable shifts in brain waves, ATP production, blood flow, and human coherence. You'll learn how quantum energy interacts with your nervous system, mitochondria, and electromagnetic environment to unlock higher states of consciousness and energy. Philipp and Dave dive into the science behind biofield technology, the real dangers of 5G and EMFs, and how to use frequency devices, structured water, and energetic optimization to enhance your metabolism, sleep quality, and emotional stability. You'll Learn: • How quantum energy measurably enhances brain coherence, ATP production, and longevity • Why EMFs disrupt your mitochondria, and the proven ways to neutralize their effects • How frequency medicine and structured water improve resilience and energy levels • What double-blind studies reveal about human performance, neuroplasticity, and healing • How to integrate quantum tech with fasting, nootropics, and supplements for full-body optimization • The role of consciousness and energy fields in unlocking true anti-aging and human potential This conversation bridges biohacking and functional medicine, exploring how quantum biology complements nootropics, fasting, ketosis, and supplements to accelerate anti-aging and brain optimization. You'll walk away with a new understanding of energy as the missing link in hacking your biology and extending your longevity. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: quantum energy, Leela Quantum Tech, Philipp Samor von Holtzendorff-Fehling, biohacking, EMF protection, frequency medicine, human performance, mitochondria, neuroplasticity, ATP production, brain optimization, anti-aging, functional medicine, structured water, consciousness, energy healing, nootropics, sleep optimization, longevity, quantum biology **Go to https://leelaq.com/dave for a discount on Leela Quantum!**Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Intro 7:04 — Why Quantum is Controversial 10:11 — How Quantum Healing Works 14:47 — EMF Effects on the Brain 17:35 — Living in the EMF Soup 20:55 — Elon Musk and EMF Denial 22:32 — How Leela Quantum Technology Works 26:29 — Water Optimization Research 34:54 — Charging Clothing and Objects 37:31 — Frequency Medicine Applications 42:03 — Skeptics Turned Believers 55:40 — The Energy of Everything (Book Launch) 59:05 — Quantum Upgrade Service Settings 1:02:21 — Protection from Negative Energy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Heart rate variability isn't just a fitness metric, it's the master signal of human performance, emotional regulation, and longevity. This episode reveals how you can use HRV to hack your nervous system, regulate stress in real time, and build true resilience from the inside out. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Rollin McCraty, Ph.D., Director of Research at the HeartMath Institute and a leading psychophysiologist exploring how the heart, brain and human consciousness are interconnected. For more than three decades his pioneering research into heart-brain communication and geomagnetic field interactions has supported the development of HRV/coherence-training tools and coherence biofeedback technology. His work has been featured in documentaries such as I Am, The Power of the Heart and The Living Matrix. Together, Dave and Dr. McCraty uncover how heart-brain coherence can improve neuroplasticity, optimize sleep, strengthen mitochondria, and create emotional stability even under extreme stress. You'll discover how five minutes a day of coherence training can elevate focus, resilience, and connection, helping every other biohack, from fasting and ketosis to supplements and nootropics, work more effectively. You'll Learn: • What HRV really measures and why it predicts performance and longevity • How coherence breathing balances your nervous system and sharpens cognition • Why emotional regulation begins in the heart, not the mind • How environmental and solar energy affect your physiology, and how to stay stable • The Navy-proven HRV method for better sleep and stress recovery • How coherence training outperforms traditional meditation for daily resilience • The measurable science behind “radiating love” and creating heart-based connection This is essential listening for anyone serious about biohacking, brain optimization, functional medicine, and anti-aging. Whether you're optimizing metabolism, fine-tuning sleep, or upgrading your energy with Danger Coffee, coherence training helps you live smarter, not harder, by syncing your biology with the rhythm of life itself. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: heart rate variability, HRV training, HeartMath, Rollin McCraty, heart-brain coherence, biohacking, emotional regulation, nervous system, stress resilience, neuroplasticity, longevity, sleep optimization, mitochondria, functional medicine, anti-aging, coherence breathing, vagus nerve, HRV recovery, brain optimization Go to https://www.heartmath.com/Dave for 15% off the HeartMath device Thank you to our sponsors! -Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. -BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • HeartMath Instagram: https://www.instagram.com/heartmath/ • HeartMath Facebook: https://www.facebook.com/HeartMath • HeartMath TikTok: https://www.tiktok.com/@heartmathinc • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — OG Biohacker 3:21 — What Is Heart Rate Variability? 7:10 — The Four Drummers: Understanding HRV Rhythms 11:50 — Real-Time Training vs Sleep Tracking 18:45 — The Science of Coherence and Consciousness 21:25 — Heart Synchronization in Groups 26:40 — Space Weather and Planetary Rhythms 31:40 — Solar Flares and Human Behavior 38:45 — The Emotional System Runs the Show 49:15 — Getting Started: Training Protocol 57:55 — Advanced Applications: Dating to Performance 1:01:46 — The Frequency Spectrum of Love 1:05:15 — The Heart's Magnetic Field and Congruence See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Discover how decoding your DNA can unlock the full potential of plant medicine. This episode delivers a cannabis masterclass for biohackers, revealing how personalized genetics are transforming human performance, brain optimization, and longevity. You'll learn how to identify your ideal cannabis and supplement protocols, balance your endocannabinoid system, and turn precision data into powerful healing. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Len May, MSc, visionary authority in personalized medicine and CEO of EndoDNA, the world leader in DNA-based wellness technology. With over 25 years of pioneering work in genomics, epigenetics, and medicinal cannabis, Len's patented DNA decoding system maps your unique genotypes to design tailor-made health solutions. His company holds the world's largest real-world efficacy database in precision wellness, integrating functional medicine, AI-driven analytics, and genetic data to create personalized blueprints for optimal brain function and performance. Together, Dave and Len explore how your genetic code determines how you respond to cannabis, psychedelics, nootropics, and supplements—and how to use that data to reduce anxiety, improve sleep optimization, and enhance focus. You'll learn how decoding your DNA can guide anti-aging strategies, mitochondrial performance, metabolism, and neuroplasticity, revealing new ways to live longer and smarter. This episode dives deep into the intersection of cannabis science, genomics, and biohacking. You'll discover how genetic polymorphisms influence mood, cognition, and stress response, and how personalized medicine can help you make smarter decisions around ketosis, fasting, and recovery. From optimizing the endocannabinoid system to hacking your biology for resilience and longevity, this is the future of functional medicine in action. You'll Learn: • How the endocannabinoid system regulates mood, focus, pain, and stress response • Which genetic polymorphisms affect cannabis sensitivity, anxiety risk, and dosing windows • How to use DNA testing to select cannabinoid and terpene ratios that fit your biology • Why delivery method matters and when sublingual dosing outperforms inhalation • How personalized cannabis protocols can support sleep optimization, recovery, and emotional regulation • The role of cannabinoids in mitochondrial function, neuroplasticity, and cognitive performance • How pharmacogenomics reduces antidepressant side effects and improves treatment matching • How to screen genetics for safer psychedelic use and avoid adverse reactions • What HLA and related markers reveal about mold sensitivity and inflammation This is essential listening for anyone serious about biohacking, brain optimization, longevity, anti-aging, functional medicine, and living Smarter Not Harder—with precision tools designed to upgrade your mind and body at the genetic level. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: cannabis biohacking, cannabis masterclass, Dave Asprey cannabis, DNA decoding, genetic testing for cannabis, personalized medicine, endocannabinoid system, cannabis genomics, cannabis and DNA, cannabis and genetics, cannabis nootropics, plant medicine biohacking, cannabis brain optimization, cannabis and neuroplasticity, cannabis for focus, cannabis and mitochondria, cannabis metabolism, cannabis for sleep, cannabis anti-aging, precision wellness, functional medicine, cannabis longevity, EndoDNA, Len May, cannabis and AI, biohacking genetics, cannabis and fasting, cannabis and ketosis, personalized supplements, cannabis and mood, cannabis stress response, genetic biohacking, cannabis cognitive performance Thank you to our sponsors! -Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. -Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. -Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. -iRestore | Use code DAVE at https://www.irestore.com/ to unlock an exclusive discount on the iRestore Elite. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 – Trailer • 1:25 – Introduction • 7:02 – Cannabis & The Endocannabinoid System • 13:30 – How It Works • 21:38 – Brain Health & Clinical Studies • 26:52 – Psychedelics & Genetic Testing • 31:37 – Genetics vs Epigenetics • 34:53 – Antidepressant Safety • 40:41 – Cannabis Success Stories • 46:02 – ADHD & Personality Genes • 50:54 – Mold, Nicotine & Mitochondria • 55:27 – GLP-1 & Metabolism • 1:00:34 – Microbiome & Medical Freedom See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dopamine isn't the enemy—low brain energy is. When your mitochondria can't make enough ATP, your neurons misfire, leading to fatigue, brain fog, and lack of focus. In this video, I explain why dopamine problems are really energy problems, how mitochondrial health drives motivation and clarity, and why creatine is one of the most effective and affordable nootropics for restoring mental performance. Learn the biohacks that protect your brain's power plants and keep you sharp all day long.Chapters0:00 – Introduction0:22 – Brain energy vs dopamine0:49 – ATP shortage causes fatigue1:53 – Prefrontal cortex and energy3:08 – Why ATP fuels focus and mood4:40 – Stress, sleep and mitochondria6:00 – Biohacks for energy production7:39 – Backup battery: phosphagen system8:46 – Creatine for brain energy & focus13:18 – Vegans, women and creatine needs15:07 – Best practices for dosing creatine17:53 – Daily creatine + electrolytesThank you to our sponsors!-ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask.Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Upgrade your biology in 10 minutes with this week's rundown from Dave Asprey. This episode breaks down the five biggest stories in biohacking and health-tech — from genetic rejuvenation to your future digital twin — giving you the tools to live longer, perform better, and stay ahead of the curve.This episode covers:• Vitamin D as the Surprising “Anti-Aging Pill”A new five-year randomized study shows that daily 2,000 IU vitamin D supplementation slowed telomere shortening by 140 base pairs compared to placebo, translating to measurable gains in biological youth. Vitamin D isn't just for bones anymore — it's a foundational longevity molecule.Source: Science Daily — https://www.sciencedaily.com/releases/2025/10/251022023132.htm• The Supercentenarian Gene That Rejuvenates Old HeartsResearchers at the University of Bristol identified a gene variant, LAV-BPIFB4, common among people living past 100, that reversed cardiac aging in animal studies — restoring blood flow, heart strength, and tissue repair with a single treatment. It's a glimpse into how gene therapy could soon democratize superhuman longevity.Source: University of Bristol News — https://www.bristol.ac.uk/news/2025/october/progeria.html• FDA Closes the “GRAS” Loophole — Supplements Enter a New EraThe FDA just ended decades of self-certification for new dietary ingredients, requiring full agency review for anything entering the market. It's the biggest shakeup in supplement regulation in years — raising quality, accountability, and trust across the entire industry.Source: Mintz FDA Flux Newsletter — https://www.mintz.com/insights-center/viewpoints/2791/2025-10-16-fda-flux-october-2025-newsletter• Microbes That Trigger Autophagy — Your Gut as an Anti-Aging SwitchScientists at the University of Basel discovered that certain dietary bacteria containing double-stranded RNA can directly trigger autophagy, the body's built-in cell-recycling system. Fermented foods like kimchi, kefir, and sauerkraut may now be proven longevity tools for activating repair from the inside out.Source: University of Basel — https://www.unibas.ch/en/News-Events/News/Uni-Research/Longevity-research—Dietary-stress-supports-healthy-aging.htmlFurther reading: Neuroscience News — https://neurosciencenews.com/dietary-rna-cellular-aging-29757/• Your Medical Avatar Is Coming — The Digital Twin of YouForbes reports on the rise of personalized “medical avatars” — AI-powered digital twins built from your wearables and biometrics that can predict health risks, recommend interventions, and evolve alongside your biology. Doctors like Daniel Kraft call it generative health — a revolution in predictive medicine where your data literally becomes your doctor.Source: Forbes Innovation — https://www.forbes.com/sites/johnwerner/2025/10/21/wearables-ai-and-your-personal-medical-avatar/This is essential listening for fans of biohacking, human performance, functional medicine, and longevity sciencewho want real, actionable tools from Dave Asprey — the father of biohacking and founder of Bulletproof Coffee.With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your lifespan, and upgrade every system in your body and mind.New episodes drop every Tuesday, Thursday, Friday, and Sunday. Dave asks the questions no one else will — and gives you the science-backed tools to become stronger, smarter, and more resilient.Keywords: vitamin D longevity, telomeres, BPIFB4 gene, cardiac rejuvenation, supplement regulation, GRAS FDA, autophagy, microbiome, fermented foods, biohacking news, medical avatar, digital twin, predictive medicine, Daniel Kraft, quantum health, wearable AI, Dave Asprey, The Human UpgradeThank you to our sponsors! TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off.HeartMath | Go to https://www.heartmath.com/dave to save 15% off.Timestamps: 0:00 — Introduction0:18 — Story 1: Vitamin D & Telomeres1:02 — Story 2: Longevity Gene Therapy1:49 — Story 3: FDA Supplement Reform2:38 — Story 4: Gut Bacteria & Autophagy3:46 — Story 5: Medical Avatars4:53 — Weekly Protocol5:42 — OutroSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This is Part 2 of the Nicotine Masterclass. If you haven't heard Part 1, start there for a full breakdown of nicotine's mechanisms, myths, and the science behind its misunderstood role in longevity, nootropics, and human performance. Nicotine is one of the most misunderstood nootropics in the world—and one of the most powerful tools for brain optimization and longevity when used correctly. In this episode, Host Dave Asprey breaks down how to harness nicotine for cognitive enhancement, metabolism, and human performance without falling into addiction. You'll learn the real science behind dosage, timing, and cycling, plus how nicotine interacts with mitochondria, acetylcholine, and neuroplasticity to boost focus, motivation, and mental energy. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR This is Part 2 of the Nicotine Masterclass. If you haven't heard Part 1, start there for a full breakdown of nicotine's mechanisms, myths, and the science behind its misunderstood role in longevity, nootropics, and human performance. Host Dave Asprey reveals practical biohacking templates for using nicotine safely and effectively—covering metabolism genetics, stack combinations, and how nicotine fits into a smarter not harder lifestyle. You'll discover how low-dose nicotine can support attention, memory, and even protect against neurodegenerative diseases like Alzheimer's and Parkinson's. Dave also shares his own five-year nicotine protocol, how he avoided dependence, and why nicotine can be a game-changer for brain and mitochondrial performance when used intelligently. You'll Learn: • How to use nicotine as a safe, powerful nootropic for brain optimization and focus • The genetics of nicotine metabolism and why dose timing matters • How to stack nicotine with caffeine, theanine, and rhodiola for maximum energy and motivation • Why nicotine enhances mitochondria and PGC-1α for better metabolism and longevity • The truth about nicotine tolerance, cycling, and how to avoid addiction • How nicotine affects sleep, neuroplasticity, and dopamine signaling • What science says about nicotine's protective effects against Alzheimer's and Parkinson's • How to integrate nicotine into a complete biohacking protocol with fasting, ketosis, and supplements This episode is essential for anyone exploring biohacking, functional medicine, fasting, ketosis, sleep optimization, and cognitive resilience. You'll learn how nicotine stacks with caffeine, theanine, rhodiola, and supplements for sharper thinking and sustained focus—plus the key mistakes to avoid so you don't wreck your sleep or metabolism. Whether you're a seasoned biohacker or just beginning your journey, this episode gives you the science, tools, and protocols to elevate your mind and body safely. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: nicotine biohacking, nicotine masterclass, Dave Asprey nicotine, nicotine nootropics, nicotine cognitive enhancement, nicotine mitochondria, nicotine and dopamine, nicotine addiction prevention, nicotine cycling, nicotine dosage, nicotine metabolism, nicotine tolerance, nicotine and longevity, nicotine patch benefits, nicotine for focus, nicotine and acetylcholine, nicotine and caffeine stack, nicotine sleep effects, nicotine and Parkinson's, nicotine brain optimization ** Listen to part 1 here: https://www.youtube.com/watch?v=WjehLsHaRnE&t=1063s** Thank you to our sponsors! -GOT MOLD? | Go to http://gotmold.com/shop and use DAVE10 to save 10% and see what's in your air. -Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 – Trailer 01:25 – Review of Pt 1 02:48 – Genetics & Metabolism 06:05 – Stacking with Other Compounds 09:23 – Tolerance & Dependence 13:42 – Fertility & Contraindications 17:05 – Real World Use Templates 21:40 – Travel & Jet Lag Protocol 24:29 – Biohacking Lifestyle Integration 25:31 – Longevity & Neuroprotection 28:24 – Medical Applications & Research 31:51 – Final Thoughts & Summary See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Modern joint pain isn't just wear and tear—it's a systemic, metabolic disease that starts years before symptoms show. In this episode, you'll learn how inflammation, mitochondria dysfunction, and immune imbalance trigger cartilage loss… and how to reverse it using targeted cytokine modulation, cellular regeneration, and smarter supplements for longevity and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Kiran Krishnan, a research microbiologist and Chief Scientific Officer at Calroy Health Sciences. He's the founder of Microbiome Labs—one of the most trusted microbiome-focused brands in functional medicine—and a formulator behind cutting-edge supplements like Arterosil and Vascanox. With over two decades of experience, Kiran has launched multiple health ventures, authored scientific textbook chapters, published clinical trials, and holds global patents in human health. He's a leading authority on systemic inflammation, mitochondrial dysfunction, and gut-driven disease—and one of the few voices making complex biology accessible for real-world results. He breaks down their new supplement Cartigenix HP, and how cytokines like IL-6 and TNF-alpha flip your cartilage cells from anabolic repair to catabolic destruction, how mitochondrial decline speeds up joint damage, and why most modern painkillers make your joints worse. You'll learn how a specialized blend of boswellia and celery seed reprograms inflammation, why walking beats medication in clinical trials, and how fasting, nitric oxide, and gut health work together to optimize joint regeneration. You'll learn: • How cartilage cells (chondrocytes) rely on mitochondria for tissue repair • Why global cytokines like IL-6 and TNF-alpha drive joint degradation and brain fog • How cartilage begins to break down in your teens—and what to do about it now • The surprising clinical data on walking distance, inflammation markers, and recovery • Why most supplements and NSAIDs fail—and what actually rebuilds joints • How diet and leaky gut create 5-day inflammation spikes from a single fast-food meal • The mitochondrial link between joint pain, cardiovascular risk, and depression • Why perimenopausal women are at 10x higher risk for arthritis—and how to prevent it • How to track your biological joint age using imaging and systemic inflammation labs This is essential listening for anyone serious about biohacking, functional medicine, pain-free aging, and human performance. Whether you're lifting heavy, walking daily, or just trying to stay mobile into old age, this episode gives you the science and tools to reverse joint degeneration and extend your healthspan. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Joint cartilage regeneration, IL-6 inflammation suppression, TNF-alpha cytokine modulation, Chondrocyte mitochondrial repair, Catabolic to anabolic tissue shift, Osteoarthritis reversal, Rheumatoid arthritis inflammation, Mitochondria and collagen synthesis, Boswellia seratol extract, Celery seed COX inhibition, Matrix metalloproteinase (MMP) inhibition, Synovial fluid inflammation, Leaky gut and joint pain, Six-minute walk test improvement, Global cytokine markers, High sensitivity CRP reduction, ESR sedimentation rate, Uric acid crystal formation, Post-prandial glucose walking, Cartilage MRI biomarkers, Functional medicine joint support, Fasted repair stacking, Vasodilation and nitric oxide, Anti-inflammatory supplement stacking, NF-kB pathway reduction, Joint space biological age, Microvascular circulation and cartilage, Caloric load and cytokine spike, Perimenopause and arthritis risk, Joint tissue anabolic activation **Get an exclusive discount for podcast listeners at calroy.com/dave : https://calroy.com/product/cartigenix-hp/?lp=dave ** Thank you to our sponsors! -BodyGuardz | Visit https://www.bodyguardz.com/ and use code DAVE for 25% off. -BiOptimizers | Go to http://bioptimizers.com/dave and use code DAVE15 to get 15% off your order. -Quantum Upgrade | Go to https://quantumupgrade.io/Dave for a free trial. -Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction 2:01 — Why Modern Medicine Fails at Joint Pain 3:07 — Painkillers That Accelerate Joint Damage 7:35 — Rheumatoid vs. Osteoarthritis Explained 8:54 — Cytokines That Destroy Cartilage 12:10 — Arthritis Begins in Your Teens 15:35 — 75% Pain Reduction in 7 Days 18:35 — The Science Behind Boswellia & Celery Seed 24:10 — Six-Minute Walk Test Results 25:45 — The $200/Month Painkiller Trap 28:53 — Proof Cartilage Can Regrow 31:01 — Mitochondria and Joint Repair 32:29 — Inflammation Links to Heart Disease 35:52 — Why Glucosamine Doesn't Work 37:07 — Silent Arthritis in 90% of Adults 40:44 — Why Women Face Higher Joint Risk After 40 45:52 — Food as the #1 Inflammation Trigger 47:23 — Fasting & Cartogenics Stack for Repair 50:27 — Movement Snacks and Efficient Training 55:54 — Why Joints Heal Slower Than Muscles 57:48 — Dave's Stack and Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Biohacking isn't just food + exercise, it's about fixing the invisible disruptors wrecking your biology. EMFs, mold, toxins, mitochondrial stress, these are the real reasons you still feel tired, foggy, or inflamed even on a perfect diet. I've been there. I lost 100 lbs, built Bulletproof Coffee, and discovered why food alone isn't enough. In this video, I'll show you what's actually holding back your energy, focus, and longevity… and how to finally feel truly bulletproof.Chapters:0:00 – Introduction1:30 – The hidden disruptors wrecking your health2:15 – EMFs: invisible energy thieves3:00 – Mold exposure: the silent killer in your home4:00 – How toxins block your nutrients5:10 – Mitochondria: the real source of energy6:20 – Detox hacks that actually work7:30 – Binders: the secret to flushing toxins8:30 – Rebuilding nutrients for lasting energy9:20 – The missing biological switch: nervous system safety10:30 – Resetting your circadian rhythm naturally11:30 – Box breathing: a biohack for instant calm12:20 – Gratitude, digestion & unlocking thrival modeConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Upgrade your biology in 10 minutes with this week's rundown from Dave Asprey. TThis episode covers:• Longevity Scores Are Going MainstreamElegant Hoopoe's new clinics are using 56 biomarkers to track biological aging — and early users are reporting up to six years reversed in under two months. Could scoring systems replace reactive healthcare?Source: Morningstar via PR Newswire — https://www.morningstar.com/news/pr-newswire/20251014ln95054• AI Heart Scans Spot Trouble SoonerHospitals are using machine learning to analyze echocardiograms in real time — making heart diagnostics faster, cheaper, and more accurate, even without top specialists on site.Source: Crescendo.AI News — https://www.crescendo.ai/news/latest-ai-news-and-updates• Brain Training That Rebuilds NeurotransmittersMcGill's INHANCE trial shows that 10 weeks of digital training on BrainHQ doesn't just improve memory — it chemically rejuvenates acetylcholine pathways. That's measurable neuroplasticity.Source: Longevity.Technology — https://longevity.technology/news/brain-training-restores-youth-to-aging-minds/• HLTH 2025 Unveils Digital Twins & Real-Time Immune WearablesThis year's HLTH conference put bio-individuality front and center: AI twins that simulate your biology, hormone-tracking wearables, and apps syncing with EMRs to turn raw data into real decisions.Source: HLTH Official — https://hlth.com/2025event• One Blood Test, Many DiagnosesNew multi-panel tests rolling out in clinics screen for dozens of diseases from a single draw — boosting compliance, streamlining early detection, and making full-spectrum testing routine.Source: Instagram Science Updates — https://www.instagram.com/p/DP0oGGTiiT5/This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: longevity score, elegant hoopoe, AI heart scans, brainHQ, acetylcholine, McGill INHANCE trial, HLTH 2025, digital twins, hormone wearables, immune tracking, biological age, multi-panel blood test, early detection, personalized medicine, Dave Asprey, Human Upgrade, biohacking news, health tech, performance medicine, smart diagnosticsThank you to our sponsors! -SKILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off.-EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction0:18 — Story 1: Elegant Hoopoe Longevity Score1:26 — Story 2: AI-Assisted Echocardiograms2:17 — Story 3: Brain HQ Cognitive Training Study3:03 — Story 4: Digital Twins at HLTH Conference4:13 — Story 5: Single Vial Blood Testing5:04 — Five Day Experiment5:46 — ClosingSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people try to “heal” their brain with supplements, mindset, or meditation—but this episode reveals the deeper protocol to actually grow a new brain, reverse stress damage, activate 1,100 healing genes, and unlock higher human performance at any age. You'll learn how neuroplasticity, mitochondria repair, plant-based NRF2 activators, and energetic practices work together to rebuild the brain and extend longevity. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Alberto Villoldo, Ph.D.—medical anthropologist, neuroscientist, energy medicine pioneer, and founder of The Four Winds Society, the gold-standard school for modern shamans. He has spent 25+ years studying Amazonian and Andean healing traditions, led the Biological Self-Regulation Lab at San Francisco State University to explore psychosomatic medicine, and authored more than 25 bestselling books on neuroscience, functional medicine, and energy healing. Few people on earth bridge ancient biohacking and modern brain science at this level. He also reveals the forms of nicotine that are safest (spoiler: it's not vapes or cigarettes), how nicotine works at the receptor level, and what the science says about long-term health effects. This episode blends functional medicine, brain optimization, and biohacking into one powerful, myth-busting breakdown. You'll learn: • How to grow a new brain every 22 days using neuroplasticity and mitochondria support • Why plant medicines and NRF2 activators can turn on 1,100 healing genes in 24 hours • The surprising link between nootropics, psychedelics, serotonin, and endogenous DMT • How mindset, belief systems, and placebo/nocebo shape immune function and metabolism • Why RFK's chronic disease warning connects to viral evolution and immune collapse • The real reason carnivore diets work—and when they fail without gut repair • Peptides, GLP-1 agonists, and the future of functional medicine hacking • Why most people sabotage themselves and how to stop fighting your own biology This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: NRF2 activation, Neurogenesis and hippocampus repair, Plant-based epigenetic triggers, Psychosomatic health, Serotonin to DMT conversion, Pineal gland methylation, Parasites and brain inflammation, Viral-driven evolution, GLP-1 agonists and longevity, Psilocybin lifespan extension, Autophagy and brain cleanup, Energetic medicine training, Functional peptides, BPC-157, Breathwork and CO2 tolerance, mTOR cycling, Cold exposure and dopamine, Mindset-driven immune function Thank you to our sponsors! • EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off. • Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. • Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. • fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. Resources: • Learn more from Alberto at: www.thefourwinds.com and www.albertovilloldo.net • Buy the book ‘Grow A New Brain': https://a.co/d/5lVhrVy • Business of Biohacking | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction & Ayahuasca Story 3:15 — Shamanism Beyond Plant Medicine 6:53 — Losing Your Mind to Evolve 10:45 — The 22-Day New Brain Cycle 12:53 — Plant Communication & Direct Knowing 15:35 — Parasites, Liver Failure & Brain Damage 20:25 — Remote Healing & CIA Research 22:40 — Tryptophan, Turkey Farmers & Brain Chemistry 25:19 — Viruses as Evolutionary Drivers 30:30 — Psilocybin & Life Extension 35:25 — Healing with Mindset + Biology 38:52 — Spirit, Purpose & Growing Gods 43:49 — Plants, Protein & mTOR 49:07 — Training the Four Brains 51:16 — Cold Exposure: Pain vs Suffering 54:40 — Who Am I? Living the Question 55:25 — Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This episode is sponsored by Magnesium Breakthrough and Sleep Breakthrough — two of my favourite biohacks for deeper sleep and better recovery. Right now you can get 15 % off either one when you use the code TONY15 at bioptimizers.com/tony   Meet Akshay Nanavati — Marine veteran, ultra-endurance athlete, and the author of Fearvana, endorsed by the Dalai Lama, and mates with Dave Asprey.  This podcast is part of my new series A Biohacker's Day. And we discuss everything from 40 years of zen, getting up and getting right to it, and spending 24 (yes twenty-four) hours on a stairclimber.  I'd love to know what you think. Follow Akshay Nanavati on Instagram.   THIS SHOW IS BROUGHT TO YOU BY: BiOptimizers Sleep Breakthrough and Magnesium Breakthrough These are BIOptimizers sleep and magnesium supplements which I take every night.  I have also been using the new Magnesium Breakthrough drink - delicious way to get magnesium. I have been putting a scoop in my protein shake after a workout.  Just go to BIOptimizers.com/tony and use code TONY15 for at least 15% off (often more). Code works worldwide, and on all their products.

Dave Asprey—serial entrepreneur, bestselling author, and Bulletproof founder—went from making $6M by 26 to losing it all two years later. By 30, a health crash (testosterone lower than his mom's, multiple diagnoses) pushed him to spend millions hacking his biology. He ultimately built Bulletproof to $140M in annual revenue—then was removed from the board in what he calls a calculated coup that cost him hundreds of millions. Now, as CEO of Upgrade Labs, he's focused on making elite biohacking accessible. This conversation goes well beyond cold plunges and butter coffee. Dave maps the decisions he wishes he'd made sooner: firing the $28M mistake, spotting narcissists quickly, and sorting win-win from win-lose people before they poison their business' culture. We explore how birth trauma shows up in leadership, why empathy drains while compassion sustains, and how to step out of the victim–perpetrator–savior triangle. He shares hiring guardrails (the “first-wiggle” rule, real reference checks, the 60-day policy) and therapeutic/energetic tools founders can use immediately. If you're building through chaos—navigating toxic team members, your own triggers, or both—you'll leave with concrete ways to protect your company, your energy, and your judgment.   Key Takeaways and Topics The $28M lesson: recognize the “first wiggle” and act right away Four categories of people (win-win to win-lose) and who to hire Red flags: instant “best friend” chemistry, envy tells, and trauma bonds How to reference-check and background diligence Empathy vs. compassion: boundaries that protect teams and CEOs Business drama patterns and how leaders step out of them Forgiveness as a nervous-system reset; going no-contact with manipulators Energy as a leadership edge: willpower and decision quality Daily levers: intermittent fasting and nighttime darkness   The Failure Factor Podcast was brought to you by Off The Field Coaching. Explore working with one of our coaches at http://offthefieldcoaching.com Hosted by Megan Bruneau: therapist, executive coach, speaker, Forbes contributor, and host of The Failure Factor. For more info, visit https://meganbruneau.com    Follow Dave Site: https://daveasprey.com/ IG: https://www.instagram.com/dave.asprey/  Linkedin: https://www.linkedin.com/in/asprey/  Follow Megan IG: https://www.instagram.com/meganjbruneau LinkedIn: https://www.linkedin.com/in/megan-j-bruneau-m-a-rcc Subscribe to the podcast newsletter at https://thefailurefactorpodcast.com

Nicotine isn't just addictive—it might be one of the most misunderstood nootropics in modern medicine. In this masterclass, you'll learn how controlled, low-dose nicotine may enhance brain performance, boost neuroplasticity, improve mitochondrial function, and potentially extend lifespan. Host Dave Asprey breaks down the surprising science behind this controversial compound, separating fact from fear—and exposing the real risks that nobody talks about. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll discover how nicotine affects neurotransmitters, why it may help with ADHD and focus, and how it compares to other cognitive enhancers like caffeine, nootropics, and even smart drugs. Dave explores how nicotine can be used to hack metabolism, enhance sleep optimization, and support fasting or ketosis protocols—if used properly. He also reveals the forms of nicotine that are safest (spoiler: it's not vapes or cigarettes), how nicotine works at the receptor level, and what the science says about long-term health effects. This episode blends functional medicine, brain optimization, and biohacking into one powerful, myth-busting breakdown. You'll Learn: • How nicotine affects mitochondria, neurotransmitters, and dopamine signaling • Why nicotine may boost neuroplasticity, memory, and attention span • How low-dose nicotine compares to caffeine, modafinil, and other nootropics • The safest delivery forms (and the ones to avoid) • Whether nicotine supports or hinders longevity and cognitive resilience • How it can be stacked with supplements, fasting, or ketosis • What functional medicine says about chronic use, addiction, and withdrawal This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Nicotine microdosing, Nicotinic acetylcholine receptors, Dopamine and motivation, Cognitive enhancement, Alzheimer's prevention, Neuroinflammation, Mitochondrial function, TNF-alpha reduction, Vagus nerve activation, Longevity biohacking, Nicotine vs smoking, Nootropics, Attention and vigilance, Ketosis and metabolism, Functional medicine, Nicotine patches and gum, Addiction and tolerance, Receptor desensitization, Withdrawal protocols, Deep work performance Thank you to our sponsors! -TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off. -HeartMath | Go to https://www.heartmath.com/dave to save 15% off. -Leela Quantum Tech | Check out all HEAL360 products and research and get 10% off at https://leelaq.com/DAVE. -Calroy | Head to https://calroy.com/dave for an exclusive discount. Resources: • Business of Biohacking | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction 1:27 — History & Background of Nicotine 4:34 — How Nicotine Works 15:12 — Benefits & Research 16:43 — Risks & Who Should Avoid It 21:39 — Delivery Methods & Dosing 26:30 — Conclusion & Next Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

These "toxic foods" are one of the biggest hidden threats to your health and most people are eating them every single day without realizing it. These cheap industrial foods are marketed as “healthy,” but the truth is they damage your cells, drive inflammation, and speed up aging. In this video, I'm exposing the dark history behind how they ended up in our food system, why regulators don't protect you, and the toxic process used to make them.I'll also show you what to cook with instead so you can lower inflammation, protect your brain, and get back the vitality the food industry has been stealing from you. If you care about longevity, energy, and real health, not marketing lies, this is one video you don't want to miss.Chapters:0:00 – Introduction0:50 – What They Don't Tell You About This2:40 – How Healthy Fats Become Toxic Poisons3:40 – The Food Industry's Biggest Switch5:37 – #1: The Everyday Additive That Wrecks Your Brain6:51 – #2: The Snack Food Staple That Fuels Inflammation7:55 – #3: The “Healthy” Oil Used in Engines8:57 – #4: The Candle Wax That Became Food9:40 – #5: The Cooking Oil That Ages You Faster10:23 – #6: The Gasoline Replacement You're Eating11:01 – #7: The Wine Waste Product in Your Pantry12:19 – Bonus: The One Contaminated with Heavy Metals13:59 – How To Protect Yourself & Choose Real Fats15:36 – Final Warning: The Food System Is Rigged_______Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

He is the co-founder of Wanderlust, a global movement that has brought together millions through yoga, mindfulness and community. Yet Jeff Krasno's story stretches far beyond festivals and studios.In this thoughtful and inspiring conversation, Jeff joins Sarah Grynberg to share the lessons of a life spent at the intersection of wellness and culture, from building Wanderlust into a worldwide phenomenon, to creating Commune Media, where he amplifies the voices of the world's leading teachers and thinkers. With honesty and depth, he explores the power of community, the role of spirituality in modern life, and why belonging is one of our most vital medicines.You'll learn:*Why community and connection are central to true healing.*How mindfulness and spirituality can ground us in a chaotic world.*What Jeff has learned about growth, resilience and meaning from building global movements.This episode is a moving reminder that wellness is not just a personal journey, but a shared one, and that the path to healing and purpose is often found together.Wanderlust WELLSPRING - October 25 & 26, 2025 in the Gold CoastSee Jeff alongside Kayla Barnes, Dave Asprey, Wim Hof, Dr David Sinclair, Dr Gabrielle Lyon, Dr Will Cole Plus 40 more! I'll be there too! Tickets on sale now via Humanitix, from $250 See more at wanderlust.com.au/eventsPurchase Sarah's book: Living A Life Of Greatness here.To purchase Living A Life of Greatness outside Australia here or here.Watch A Life of Greatness Episodes On Youtube here.Sign up for Sarah's newsletter (Greatness Guide) here.Purchase Sarah's Meditations here.Instagram: @sarahgrynberg Website: https://sarahgrynberg.com/Facebook: facebook.com/sarahgrynbergTwitter: twitter.com/sarahgrynberg Hosted on Acast. See acast.com/privacy for more information.

What if you could improve your mitochondria, oxygen efficiency, and recovery in just 20 minutes a day—by breathing energized water? This episode explores one of the most surprising breakthroughs in biohacking and how it can help you live longer, think clearer, and perform better. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Rowena Gates, co-founder of NanoVi, a therapeutic device backed by biophysics research that supports protein repair and mitochondrial communication. Her work reveals how structured water inside your cells drives neuroplasticity, cellular regeneration, and stress resilience—offering a new pathway to recovery, energy, and longevity. You'll learn how structured water affects mitochondrial efficiency, how it compares to recovery methods like cold therapy and fasting, and why improved VO₂ max may correlate with a longer lifespan. Dave and Rowena also explore how NanoVi stacks with supplements, nootropics, ketosis, and functional medicine to enhance brain optimization, metabolism, and human performance. You'll Learn: • How structured water boosts mitochondrial function and VO₂ max • The difference between hydration and energized cellular water • What happens to your brain and heart rate variability in 20 minutes of NanoVi use • The link between water structure, protein repair, and recovery • How biohackers combine NanoVi with fasting, cold therapy, and sleep optimization for faster results • Why stronger mitochondrial communication can extend lifespan and upgrade cognitive function They explore how structured water, mitochondrial repair, and recovery science intersect to create a smarter approach to health and longevity. You'll also learn how optimizing cellular communication, oxygen efficiency, and stress resilience can accelerate healing, improve focus, and extend lifespan. This is essential listening for anyone serious about biohacking, human performance, and longevity, and for those who want to understand how functional biology and mitochondrial science are redefining recovery, energy, and aging. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: NanoVi, Structured water, Energized water, Biohacking, Dave Asprey, Mitochondrial repair, Mitochondrial communication, Human performance, Longevity, Recovery science, Oxidative stress, Protein repair, Redox signaling, Cellular hydration, Functional medicine, VO₂ max, Neuroplasticity, Brain optimization, Cellular energy, Stress resilience, Cold therapy, Fasting, Sleep optimization, Breathwork, Nootropics, Metabolism, Oxygen efficiency, ATP production, Cellular regeneration, Anti-aging, Smarter Not Harder **To level up your mitochondria with a NanoVi: visit https://eng3corp.com/dave/ ** Resources: • Business of Biohacking Summit | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Introduction to NanoVi 4:01 — How to Use NanoVi 6:23 — Understanding Ordered Water 9:16 — Scientific Evidence & Studies 13:02 — Pricing & Accessibility 15:02 — Mitochondrial Function & MiScreen Results 19:55 — Brain Function & Cognitive Benefits 23:47 — How Ordered Water Works 27:34 — Cellular Communication & Fascia 30:14 — Heart Rate Variability & Stress Reduction 34:54 — Athletic Performance & Recovery 38:52 — Mental Health & Sleep Benefits 42:00 — Supplement Stacking 45:50 — Deep Sleep & Parasympathetic State 48:48 — Chronic Conditions & Fatigue 51:54 — Meditation & Brain Training 55:42 — Brain Injury & Resilience 59:36 — Conclusion & Where to Get It See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

AI is transforming medicine at a speed never seen before. In this episode, you'll discover how digital twins and artificial intelligence will revolutionize drug discovery, eliminate human trials, and personalize your biology for longevity and high performance. Host Dave Asprey breaks down how AI can now simulate virtual cells and tissues, running clinical experiments in minutes instead of years to create truly individualized medicine. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dr. Derya Unutmaz is a world-renowned immunologist, systems biologist, and professor at The Jackson Laboratory. With more than 150 scientific papers, he's a leading expert in immune system research and one of the first scientists to pioneer the concept of digital twins for biology. His groundbreaking work uses AI to model how immunity, metabolism, and aging interact—creating new possibilities for personalized medicine, disease prevention, and lifespan extension. Host Dave Asprey and Dr. Unutmaz reveal how AGI will soon outperform doctors, accelerate functional medicine, and optimize human biology far beyond today's standards. You'll learn how the immune system drives inflammation and aging, how to re-engineer it for resilience, and why compounds like GLP-1 and metformin may add years to your life. You'll Learn: • How digital twins will end human drug testing • Why AGI could replace doctors and computer jobs within five years • How AI models immune function, metabolism, and aging • The role of mitochondria and inflammation in longevity • How GLP-1 drugs and metformin extend lifespan • What continuous biological monitoring means for health tracking • How AI is transforming functional medicine and personalized care • Why NAD and energy metabolism are key to human performance They explore how artificial intelligence, biohacking, and systems biology intersect to create a smarter approach to health and longevity. You'll also learn how understanding immune balance, metabolism, and mitochondrial function helps build resilience and extend your lifespan. This is essential listening for anyone serious about biohacking, hacking human performance, and extending longevity through personalized medicine, functional biology, and cutting-edge AI innovation. This is essential listening for anyone serious about biohacking, hacking human performance, improving mobility, and extending longevity. You'll also learn how neuroplasticity, metabolism, and brain optimization all connect to the way you move. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: AI medicine, Digital twins, Functional medicine, Biohacking, Longevity, Immune system, Inflammation, Personalized medicine, GLP-1 therapy, Metformin, NAD boosters, Mitochondrial function, Metabolism, AGI, Clinical trials, Human performance, Aging research, Systems biology, Immunology, Smarter Not Harder Thank you to our sponsors! BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. MASA Chips | Go to https://www.masachips.com/DAVEASPREY and use code DAVEASPREY for 25% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order Resources: • Keep up with Derya's work: https://x.com/derya_?lang=en • Business of Biohacking Summit | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 00:00 — Trailer 01:25 — Intro 02:26 — AI's Role in Extending Lifespan 02:56 — Regulatory Frameworks and Medical Adoption 05:19 — Problems with the Immune System 08:19 — Chronic Fatigue and Long COVID Research 10:32 — Modern Testing and Multi-Omic Analysis 14:07 — Personal Longevity Strategy and Supplements 15:17 — Understanding Exhausted Cells 23:43 — Personalization in Medicine and AI Analysis 31:35 — Longevity Escape Velocity 36:13 — AI Doctors and Prescriptions 39:55 — Data Quality Concerns in AI Training 43:19 — The Future of Wearable Technology 45:50 — Revolutionizing Education with AI 49:04 — The Future of Higher Education 52:03 — Future of Work and AI Agents See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people think about heart disease and metabolism when they talk about longevity, but too few talk about joint health. In this episode, you'll discover how to biohack your joints to prevent pain, reverse damage, and move like you're decades younger. Host Dave Asprey reveals how functional movement, core stability, and recovery can transform joint health, helping you maintain pain-free performance for life. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Dr. Jason Snibbe is a globally recognized, board-certified orthopedic surgeon and a pioneer in advanced, minimally invasive, and robotic surgeries of the shoulder, elbow, hip, and knee. Fellowship-trained in Sports Medicine and Robotic Joint Reconstruction, he has achieved the lowest complication rate at Cedars-Sinai Medical Center and is the official orthopedic surgeon for the Los Angeles Clippers. He also serves as an orthopedic consultant for the Los Angeles Lakers, Los Angeles Sparks, Los Angeles Angels of Anaheim, and Los Angeles Kings. As a founding and managing partner in DOCS Spine and Orthopedics and Docs Surgical Hospital, Dr. Snibbe lectures and trains surgeons around the world in his specialized techniques. Host Dave Asprey and Dr. Snibbe uncover how weak glutes, poor core engagement, and bad footwear accelerate joint aging, and how functional movement training and fascia care can protect your body from surgery. You'll learn why proper biomechanics are central to human performance and longevity, how hypermobility and fascia impact neuroplasticity, and the latest biohacking tools for recovery and joint regeneration. You'll Learn: • The real cause of joint damage and how to prevent it • How to build a stronger core and glutes for long-term joint stability • Why footwear choices can make or break your movement quality • The truth about fascia, stretching, and strength training • When to use PRP, stem cells, and biologics for healing • How hypermobility affects your joints, brain, and longevity • Daily mobility and recovery habits that prevent future surgery They explore how biologics like PRP, stem cells, and exosomes are changing orthopedic recovery and joint repair, and why functional medicine is moving beyond surgery toward regeneration. You'll hear how precision movement, fascia work, and strength training protect your joints and enhance human performance and longevity. This is essential listening for anyone serious about biohacking, hacking human performance, improving mobility, and extending longevity. You'll also learn how neuroplasticity, metabolism, and brain optimization all connect to the way you move. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Joint biohacking, Orthopedic regeneration, Functional movement patterns, Core stability training, Glute activation exercises, Fascia mobility, Hypermobility syndrome, Ehlers-Danlos collagen disorder, Foot biomechanics, Pronation and supination, Arch support orthotics, Barefoot gait training, Stem cell joint repair, PRP knee therapy, Exosome orthopedic recovery, Meniscus tear alternatives, Robotic joint surgery, Posture correction, Gait analysis technology, Pain-free longevity Thank you to our sponsors! TRU KAVA | Go to https://trukava.com/ and use code DAVE10 for 10% off. BON CHARGE | Go to https://boncharge.com and use code DAVE for 15% off. OneSkin | For a limited time, try OneSkin for 15% off with code DAVE at https://www.oneskin.co/DAVE Business of Biohacking Summit | Register to attend October 20-23 in Austin, TX https://businessofbiohacking.com/ Resources: • Learn more about Dr. Snibbe's work: https://www.drjasonsnibbe.com/ • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 — Trailer • 1:28 — Introduction • 2:38 — The Kinetic Chain • 9:34 — Core and Glutes • 12:18 — Stretching and Fascia • 17:32 — Sleep and Recovery • 18:49 — Vibration Therapy • 23:47 — Gait and Compensation • 30:47 — Robotic Surgery • 34:28 — Future of Medicine • 39:23 — Footwear Mistakes • 48:48 — Wearables and Tech • 55:13 — Stem Cells and Biologics • 1:01:20 — Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

You don't deserve to go to the next level until you beat the current one. In this encore episode of The Game Changing Attorney Podcast, Michael Mogill sits down with Eric Siu, entrepreneur, investor, and author of Leveling Up. From esports to business, Eric has turned the lessons of gaming into a powerful framework for growth, resilience, and long-term success. Together, they explore how to reframe pain into fuel, why mindset compounds like interest, and what it truly takes to keep leveling up in life and business. Here's what you'll learn: How to turn setbacks and psychological pain into power-ups for growth Why focusing on endurance, grit, and long-term bets separates winners from the rest The mindset shifts that transform gaming lessons into real world business advantages  The ultimate game is not business or gaming. It is learning how to keep leveling up every single day. ---- Show Notes: 02:39 – How gaming built resilience, teamwork, and skills Eric now applies to business 05:45 – Why gaming, Bitcoin, and other trends are dismissed as “toys” before going mainstream 07:10 – The power of community and how EverQuest shaped Eric's mindset 08:59 – Defining “power ups” and how habits and mental models fuel growth 13:55 – Why patience and endurance are essential for compounding success 20:48 – Building a brand by teaching, sharing, and learning in public 22:49 – How focus beats shiny object syndrome and leads to faster success Links & Resources: Leveling Up: How to Master the Game of Life by Eric Siu Atomic Habits by James Clear Naval Ravikant Warren Buffett Farnam Street – The Knowledge Project Podcast EverQuest and StarCraft ---- Do you love this podcast and want to see more game changing content? Subscribe to our YouTube channel. ---- Past guests on The Game Changing Attorney Podcast include David Goggins, John Morgan, Alex Hormozi, Randi McGinn, Kim Scott, Chris Voss, Kevin O'Leary, Laura Wasser, John Maxwell, Mark Lanier, Robert Greene, and many more. —- If you enjoyed this episode, you may also like: 402. How to Hack Your Biology for an Unfair Edge with Dave Asprey 353. How He Trained His Mind to Never Quit — Using Something You'd Never Guess with James Lawrence 332. Cliff Bleszinski — What the Legal Industry Can Learn From the Gaming Industry

Remote work might feel like freedom, but your biology disagrees. In this video, I break down how your work-from-home setup is hijacking your hormones: crushing testosterone, spiking cortisol, and wrecking insulin sensitivity. I'll show you exactly how posture, light, movement, and meal timing secretly control fat gain, energy crashes, and libido drops... and how to take back control without quitting your job or starving yourself. This is about biohacking your environment to work for you—not against you.Chapters:0:00 – Introduction1:04 – How Working From Home Disrupts Your Biology1:58 – The Silent Hormonal Downshift of Remote Workers3:29 – How Posture Sends Stress Signals to Your Brain4:49 – Fix This: 3 Postural Resets to Normalize Hormones5:50 – The Hormone Remote Work Destroys Most: Insulin6:59 – How To Restore Insulin Sensitivity9:45 – Why Light Is More Powerful Than FoodConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comTrueDark Glasses: https://truedark.com/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Upgrade your week in just 10 minutes with D(AI)ve Asprey's essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. This episode covers: • Apple Cider Vinegar Myth Busted A weight-loss study just got retracted. ACV will not melt fat, but it may blunt glucose spikes or ease digestion when diluted in water before carb-heavy meals. Skip the shots and protect your teeth. Source: https://www.sciencedaily.com/releases/2025/10/251001092216.htm • NMN Is Back The FDA reversal puts NMN back on shelves as a clean NAD precursor. Dave explains why quality, cycling, and stacking with anti-inflammatory strategies make the difference. Source: https://www.prnewswire.com/news-releases/renue-by-science-celebrates-fda-reversal-confirming-nmn-is-lawful-for-use-in-dietary-supplements-302573317.html • Poor Sleep Ages Your Brain Machine learning MRI studies show poor sleep makes your brain biologically older and raises dementia risk. Dave shares the three dials to track (deep sleep, REM, resting heart rate) and the three biggest levers to fix them. Source: https://www.sciencedaily.com/releases/2024/10/241023171543.htm • Psilocybin for Lasting Reset New research finds a single guided dose can unlock plasticity, ease pain patterns, and lift mood for weeks. Dave outlines safe protocols, integration steps, and why it is a strategic reset tool, not a party trick. Source: https://www.sciencedaily.com/releases/2025/06/250616040215.htm • AI Detects Cancer Earlier A new AI tool called DOLPHIN can find hidden genetic markers to flag cancer risk sooner. Pairing high tech scans with low tech terrain fixes like sleep, muscle, and insulin control is the prevention model that works. Source: https://www.sciencedaily.com/releases/2025/10/251001092206.htm All source links provided for easy reference to the original reporting and research above. This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Apple cider vinegar, weight loss myths, NMN supplements, NAD precursors, cellular energy, sleep and dementia, brain aging, deep sleep optimization, REM sleep, psilocybin therapy, BDNF, neuroplasticity, pain relief, mood reset, AI cancer detection, early cancer screening, biohacking news, longevity science, Dave Asprey, Human Upgrade podcast Thank you to our sponsors! Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave. LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction 0:18 — Story 1: Apple Cider Vinegar and Weight Loss 1:49 — Story 2: NMN is Back in Supplements 3:31 — Story 3: Sleep and Brain Health 5:39 — Story 4: Psilocybin and Lasting Relief 7:49 — Story 5: AI Tool DOLPHIN for Early Cancer Signals 9:48 — Conclusion & Weekly Roundup See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Gravity may be the most ignored signal in human biology, and it could be the missing key to unlocking fat loss, brain optimization, and true longevity. In this episode, you'll learn how Earth's pull shapes your metabolism, mood, and resilience, and discover practical hacks to fight “gravity intolerance” so you can perform better, live longer, and upgrade every system in your body. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Brennan Spiegel, a Professor of Medicine and Public Health at UCLA, Director of Health Services Research at Cedars-Sinai, and author of Pull: How Gravity Shapes Your Body, Steadies the Mind, and Guides Our Health. A leading voice in digital health and immersive medicine, Dr. Spiegel brings decades of clinical and research experience exploring the intersection of the gut-brain axis, neuropsychology, and mind-body medicine. In this episode, he reveals why gravity influences everything from gut health to depression — and why modern medicine has largely ignored its role. His work bridges functional medicine, neuroscience, and biohacking to uncover a hidden force that shapes human performance at every level. You'll Learn: • Why gravity is the most ignored biohacking signal in human health • How gravity intolerance shows up as back pain, fatigue, obesity, and depression • The surprising connection between gravity, serotonin, and mood regulation • How weighted vests, balance boards, and proprioception training hack graviception • Why sleep optimization, posture, and fascia resilience are gravity-based health tools • How Earth's pull influences gut health, metabolism, and even consciousness You'll learn how gravity connects to obesity, back pain, blood pressure, serotonin, and even consciousness. Dave and Dr. Spiegel explore how weighted vests, balance boards, vibration, and sleep optimization can hack your body's response to gravity. This channel dives into mitochondria, neuroplasticity, fasting, ketosis, supplements, and how biohackers can apply these insights alongside tools like cold therapy, nootropics, and even Danger Coffee to build resilience and extend longevity. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Gravity intolerance, Graviception, Serotonin and gravity, Tensegrity fascia system, Interstitium organ discovery, Piezoelectric cell membranes, Weighted vest training health, Balance board proprioception, Inclined bed sleep therapy, Gravity and depression, Obesity as a gravity disease, Low blood pressure gravity link, Crohn's disease altitude flares, Gravity and microbiome diversity, Glymphatic drainage sleep optimization, Space travel gravity health risks, Astronaut vision loss microgravity, Vagus nerve and gravity, Collagen and gravity resilience, Barefoot running gravity mechanics Thank you to our sponsors! Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Timeline | Head to https://www.timeline.com/dave to get 20% off. Resources: • Pre-order Brennan's Book: https://a.co/d/ik2C9iB • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:30 — Intro 4:14 — Gravity and Human Evolution 5:39 — Why Medicine Ignores Gravity 8:43 — Signs of Gravity Intolerance 12:18 — Training Gravity Resilience 16:46 — Gravity in Space 20:34 — Managing Gravity When Flying 23:59 — NASA's Gravity-Diet Link 26:55 — Serotonin and Gravity 37:42 — Gravity and Sleep 50:24 — Obesity as a Gravity Issue 55:39 — Movement and Balance 57:38 — Gravity-Resistant Exercises See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people chase fat loss, focus, and energy with caffeine or stimulants, but the real key to brain optimization and human performance is a pharmaceutical nootropic that activates your wakefulness circuits without jitters or a crash. In this episode, you'll learn how Modafinil upgrades mitochondria, sharpens neuroplasticity, improves metabolism, and extends longevity with evidence-based tools used by elite thinkers, fighter pilots, and world leaders. This is not a sales pitch. It is an educational masterclass on how to upgrade your brain beyond what it can ever do naturally. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey takes you inside the full playbook of Modafinil, a prescription nootropic often called the “real Limitless pill.” With over 20 years of personal experience using it daily alongside biohacking stacks of supplements, fasting, ketosis, cold therapy, sleep optimization, and Danger Coffee, Dave explains why Modafinil is more than just a wakefulness drug. It is a brain optimization tool that supports mitochondrial energy, resilience, and cognitive clarity. Together with decades of research, Dave shows you how Modafinil compares to stimulants like Adderall and caffeine, why it was adopted by Air Force pilots and Wall Street executives, and how functional medicine strategies can help you safely integrate it into a broader biohacking and longevity stack. This is a masterclass in hacking cognition and performance, designed for anyone who wants a sharper brain, stronger metabolism, and a more resilient body. You'll learn: • How Modafinil works as a nootropic without overstimulating dopamine • The connection between mitochondria, neuroplasticity, and human performance • Why Modafinil may protect against brain aging and inflammation • How to dose, stack, and cycle Modafinil with supplements and nutrition • What to expect from Modafinil compared to stimulants like Adderall or caffeine • The risks, side effects, and who should avoid it This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a transparent look at the world's most famous cognitive enhancer. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Modafinil, Armodafinil, Adrafinil, Real Limitless pill, Smart drugs, Eugeroic drug, Nootropics for focus, Orexin activation, Dopamine modulation, Mitochondria ATP production, Neuroplasticity enhancers, Jet lag treatment, ADHD alternative, Poker player focus enhancer, Modafinil stack, Modafinil and L-theanine, Modafinil and NAD+, Modafinil side effects, Stevens Johnson syndrome risk, Alzheimer's prevention modafinil Thank you to our sponsors! Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino. ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 — Trailer • 1:22 — Origin of Modafinil • 3:48 — Personal Experience • 8:22 — What to Expect • 9:37 — What Is Modafinil • 16:09 — How Modafinil Works • 19:36 — Benefits & Cognitive Upgrades • 25:36 — Dosing, Stacking, and Usage Tips • 28:17 — Side Effects and Safety • 31:37 — Sourcing and Legal Aspects • 36:55 — Research and Future Uses • 42:17 — Stacking for Biohacking • 47:07 — Recap and Final Advice See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most people are struggling with fat loss, low energy, and hormone chaos—and they don't even realize the real problem isn't their diet or workout plan... it's their liver. In this episode, I break down how your liver controls fat-burning, energy, and hormone regulation—and why things like poor bile flow and mineral deficiencies are sabotaging your results. I'll show you how to fix your metabolism by targeting the real root cause. This is biohacking 101—backed by science, and built to work.Chapters:0:00 – Introduction1:06 – The Liver: Your Metabolic Engine2:23 – Why Your Detox System is Overwhelmed3:58 – The 3 Gs That Help Detox Properly4:15 – The Role of Bile (and Your Gallbladder)5:48 – Signs of Sluggish Bile Flow6:43 – How to Get Bile Moving Again7:18 – Estrogen, Cortisol, and Fat Storage8:37 – The Real Fix for Hormone ImbalanceConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Upgrade your week in just 10 minutes with D(AI)ve Asprey's essential rundown on what matters most in longevity, biohacking, AI health tech, and medical freedom. Each story includes trusted source links—so you can check the facts. This episode covers: - Rapamycin's Reality Check: A sweeping new review (September 24) finds that the promise of rapamycin for longevity in healthy adults is still weak and inconsistent. Dave shares why lifestyle levers (fasting, protein timing, smart training) come first, and any rapamycin experiment should be clinician-guided and tracked with labs. Source: Aging-US press release – September 24, 2025 and EurekAlert science brief – September 24, 2025 - Senolytics Get Precise: New research (September 23) shows that not all “zombie cells” (senescent cells) are equal in how they respond to anti-aging drugs—so future protocols will be timed and typed, not one-size-fits-all. Source: Aging-US research stream – September 23, 2025 - AI Healthcare: Promise and Pause: The latest market outlook (September 23) says AI in healthcare is surging toward a $100B+ market by 2030, but 70% of doctors still want humans in the loop for diagnosis. Dave shares how to use AI as your copilot—not your captain. Source: Crescendo.ai – September 23, 2025 - Medical Policy Meets Machine Logic: A new federal pilot now lets AI approve or deny Medicare coverage, possibly cutting off therapies before a human review happens. Dave explains how to demand explainability, fair appeals, and human override to protect access. Source: KFF Health News policy rundown – September 25, 2025 - Longevity Headlines You Can Use: Forest bathing wins renewed praise for helping with blood pressure and stress. Northwestern's SuperAger project links strong social ties to resilient brain health. Human trials now test an antibody therapy to regrow lost teeth. Source: XandroLab Longevity Roundup – Week of Sept 22–25, 2025 Action steps for the week: Try fasting windows and smart protein clustering for mTOR modulation. Let AI help summarize your health data—but get decisions confirmed by your clinician. If you or your family touch Medicare, keep thorough documentation and demand human review. Soak in green spaces, reconnect socially, and watch for cutting-edge therapies. All source links provided for easy reference to the original reporting and research above. This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Rapamycin, mTOR modulation, longevity, biohacking, senolytics, zombie cells, AI healthcare, Medicare coverage, human trials, forest bathing, SuperAger, brain health, fasting, protein cycling, medical freedom, anti-aging, personalized medicine, health tech, Dave Asprey, Human Upgrade podcast Thank you to our sponsors! LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Intro 0:18 — Rapamycin Hype Check 1:07 — Senolytics Leveled Up 2:41 — AI in Healthcare 3:11 — AI Between You and Your Doctor 5:50 — Three Longevity Angles 7:59 — Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your mitochondria are the power plants of your cells, and when they break down, you lose energy, brain sharpness, and resilience against aging. In this episode, you'll learn how to hack your mitochondria to supercharge human performance, prevent decline, and extend longevity with tools that are natural, effective, and backed by decades of research. Watch the condensed video highlight version of this episode (and much more!) on YouTube: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Catharine Arnston, founder of ENERGYbits, recent PhD graduate, and one of the world's top experts on algae and functional medicine. Entering her 70th year without medications, with the cognition to finish a doctorate, and the health markers of someone decades younger, Catharine is living proof of how mitochondria and nutrition shape aging, brain optimization, and resilience. Together they break down why mitochondria fail after age 30, how algae works as a master supplement to restore superoxide dismutase (SOD) and glutathione, and what happens when you give your cells the nutrients they're wired to need. They uncover how mitochondria connect to energy, inflammation, metabolism, and cellular resilience. This is a masterclass in hacking energy and longevity, built for people who want to upgrade every system of the body and mind. You'll learn: • Why mitochondria decline after age 30 and how to stop it • The role of superoxide dismutase (SOD) and glutathione in preventing cellular “rust” • How spirulina and chlorella outperform most supplements for detox and energy • The connection between mitochondria and brain optimization • Why men's higher iron levels accelerate aging and how algae helps balance it • The real link between metabolism, inflammation, and longevity • How to build a mitochondria-first biohacking stack that actually works This is essential listening for fans of biohacking, hacking human performance, functional medicine, and longevity who want actionable tools from Host Dave Asprey and a guest who embodies what it means to age with energy, clarity, and vitality. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Catharine Arnston, mitochondria, biohacking, algae supplements, spirulina, chlorella, superoxide dismutase, SOD, glutathione, metabolism, longevity, human performance, brain optimization, functional medicine, supplements, neuroplasticity, nootropics, ketosis, fasting, cold therapy, sleep optimization, carnivore, Danger Coffee, Smarter Not Harder, Dave Asprey, Human Upgrade podcast **CTA: Go to www.energybits.com and use code ‘BEYOND' for a 20% discount** Thank you to our sponsors! HeartMath | Go to https://www.heartmath.com/dave to save 15% off. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. STEMREGEN | Go to https://stemregen.co/dave25 and use code DAVE25 for 25% off your order. Resources: • Danger Coffee: https://dangercoffee.com/discount/dave15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:18 — Intro 3:03 — Longevity & Algae 8:48 — Mitochondria & ATP 13:08 — Free Radicals & SOD 13:18 — Aging After 30 17:18 — Men vs Women in Aging 24:18 — Mitochondrial Breakdown 30:03 — Algae for Mitochondria 37:18 — SOD, Glutathione & Manganese 45:18 — Algae Dosing Tips 51:18 — Processing & Quality 58:18 — Carnivore vs Plants 1:00:48 — Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your brain isn't as rational as you think, and that blind spot can wreck your decision-making, relationships, and even your health. In this episode, you'll learn how to spot the hidden cognitive traps that even the smartest people fall for, and how to upgrade your thinking so you can perform better, live longer, and make choices that actually serve you. Watch the condensed video highlight version of this episode (and much more!) on YouTube: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Steven Pinker, a world-renowned cognitive psychologist, Harvard professor, and bestselling author whose research reshaped how we understand language, bias, social norms, and rationality. Pinker's decades of scholarship make him a trusted guide to the mechanics of the mind and the behaviors that either elevate or derail human performance and longevity. Together they break down how the brain actually reasons, why smart people still fall for tribal thinking, what current AI gets wrong about human intelligence, and how “common knowledge” quietly governs cooperation, law, and civility. This is a masterclass in brain optimization through better thinking, built for people who care about biohacking, hacking mental models, neuroplasticity, and high-performance decision-making. You'll learn: • How to recognize and counter the “my-side bias,” even if you're highly intelligent • Why common knowledge creates and sustains social norms and coordination • The art of indirect speech and tact, and how to calibrate your words to reduce social risk • Simple upgrades that make video calls feel closer to real eye contact and why that boosts trust • What today's AI gets wrong about minds and why models hallucinate • Rational habits that work in the real world: steelmanning, probabilistic thinking, adversarial collaboration, and making bets as a tax on bad arguments • Why liberal democracy fits human nature better than autocracy and how norms erode or hold • How to rebuild face-to-face social skills in a screen-first culture to improve resilience and performance This is essential listening for fans of biohacking, brain optimization, human performance, neuroplasticity, and longevity who want clear, usable frameworks to think better and live better with Dave Asprey. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio-only), and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Steven Pinker, cognitive psychology, rational thinking, my-side bias, human nature, common knowledge, cognitive bias, AI and human intelligence, democracy and human behavior, social norms psychology, decision-making hacks, brain optimization, biohacking the mind, mental performance, neuroplasticity, rationality movement, bias and longevity, functional intelligence, Human Upgrade podcast, Dave Asprey, thinking traps, steelmanning, epistemic humility, outrage economy, psychology of power, critical thinking upgrade, hacking human performance Thank you to our sponsors! KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. **Order Steven's new book WHEN EVERYONE KNOWS THAT EVERYONE KNOWS...: COMMON KNOWLEDGE AND THE MYSTERIES OF MONEY, POWER, AND EVERYDAY LIFE: HTTPS://TINYURL.COM/V685EVZR Resources: • Steven's Website: https://stevenpinker.com/ • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com• Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 0:59 — Introduction 1:58 — Human Nature 3:30 — Cognitive Psychology 5:46 — Academia Path 7:32 — Canada vs. U.S. 8:42 — College Value 12:08 — Curiosity 15:25 — Government & Humans 19:56 — AI & Cognition 24:45 — Fairness & Justice 32:56 — Social Norms 47:12 — Communication Skills 55:32 — Virtual Society 57:20 — Personal Biases See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

If you feel like your brain's stuck in first gear, losing focus, forgetting simple things, feeling mentally sluggish—you're not alone. I lived with brain fog for 15 years while building companies in Silicon Valley, and no productivity hack or double espresso fixed it. In this episode, I'll show you how to clear brain fog at the cellular level by restoring mitochondrial energy, ditching brain-damaging foods, optimizing sleep, and upgrading your nutrition. These are the exact science-backed steps that got me back to feeling sharp, focused, and fully me. Let's turn your brain back on.Chapters:0:00 – Introduction0:49 – The Root Cause of Brain Fog1:26 – What Most People Get Wrong2:20 – How to Fix Your Mitochondria2:57 – Food: Fuel or Poison4:48 – The 4 Brain Poisons Killing Your Focus5:20 – Exercise for Brain Energy (Not Burnout)7:55 – Brain Fog Supplements That WorkBrain fog supplement: https://shopsuppgradelabs.com/products/brain-101, use code DAVE15 Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ and https://m.facebook.com/Thehumanupgrade/See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.