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In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Maca on Men's Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Shiva4Senate 2026: The Middle Works. Left and Right Don't.
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Licorice on Immune Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Dr.SHIVA, MIT PhD – Science Summit on Applying the Scientific Method to Determine Earth's Geometry: Round or Flat.
Discover why Shell, Eni, and MCJ invested in this molten borate carbon capture tech led by an MIT PhD.
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Moringa on Hair Loss: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Shiva4Senate 2026: Our History of Fighting and Winning. The Only True Opposition Beyond The Two Fakirs Trump and Mamdani
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Turmeric on Eye Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Berberis on Aging: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Harvard and MIT Tenured Professors Brahmins of the SWARM
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Ginseng on Alzheimer's Disease: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Green Tea on Cardiovascular Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Berberis on Diabetes: A Whole Systems Approach
Send us a textIn this episode, we sit down with Don Kieffer, senior lecturer at MIT Sloan School of Management and co-author of There's Gotta Be a Better Way, to talk about what actually makes companies run well. Don has spent decades helping organizations, from Harley-Davidson factory floors to biotech labs, design better systems that unlock real performance. We break down the five-principle framework he developed with his co-author, Nelson Repenning, an MIT PhD, MIT Sloan professor, and leading expert in operations and systems thinking, for building operational excellence: solving the right problem, structuring for discovery, connecting the human chain, regulating for flow, and visualizing the work.Through stories that range from front-desk hotel check-ins to a corrugated cardboard plant and even private equity fundraising pipelines, Don shows how tiny operational tweaks can deliver huge impact. We explore why firefighting cultures keep companies stuck in a “capability trap,” why automation without fixing the human system first is a mistake, and why the best private equity playbooks focus on execution, not spreadsheets. For founders, operators, and investors alike, this is a practical, no-fluff conversation about how businesses actually scale.Before diving into operations, we also touch on recent rumblings in credit markets, continuing our discussion on the failed refinancing of First Brands and the liquidation of TriColor to bank fraud write-offs and how credit default swaps can amplify market stress. It's a lively, two-part arc: first, the operational playbook; next, how top investors at Private Equity firms think about value creation inside portfolio companies.Check out the book HEREFor 20% off Deleteme, use the code TWSS or click the link HERE! Sign up for our LIVE Virtual Bootcamps! 2-Day Financial Modeling Bootcamp Master the technical Excel and accounting skills essential for investment banking, private equity, and fundamental investing. (Learn more HERE) Global Markets & Investing PlaybookA one-day crash course on the financial ecosystem, perfect for anyone seeking a big-picture understanding of how global markets and Wall Street fit together. Our content is for informational purposes only. You should not construe any such information or other material as legal, tax, investment, financial, or other advice. (Learn more HERE)
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Bitter Melon on Lung Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Nutmeg on Colon Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Ganoderma on Insomnia: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Rhodiola on Inflammation: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about U.S. SENATE 2026 Announcement. Shiva4Senate.com
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Fenugreek on Women's Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Black Pepper on Immune Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about SCIENTIFIC METHOD and Systems Science. How WE Win Truth Freedom Health.
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Lavender on Skin Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Saw Palmetto on Men's Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Cardamom on Gut Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Centipeda minima on Hair Loss: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Yogurt on Aging: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about WHY The SWARM Killed Charlie Kirk. Time for REAL Solutions By The People, For The People.
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Ginkgo biloba on Alzheimer's Disease: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Ginkgo biloba on Alzheimer's Disease: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Tinospora cordifolia on Diabetes: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Licorice on Lung Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Valerian on Insomnia: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Sesame Seeds on Colon Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Shatavari on Women's Health: A Whole Systems Approach
Learn how to slow, and even reverse, your biological age with cutting-edge science on the molecule that controls your longevity. Host Dave Asprey sits down with Dr. Leonard Guarente, an MIT PhD and one of the most respected longevity researchers in the world, to reveal how NAD+, sirtuins, and DNA methylation clocks can help you hack aging, upgrade your mitochondria, and extend your healthspan. This episode gives you the real science, proven by over 250 studies, behind supplements, nutrition, and biohacking tools that actually work for brain optimization, metabolism, and human performance. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR You'll learn why NAD+ is a master regulator of mitochondrial health, how DNA methylation clocks accurately measure biological age, and why boosting sirtuin activity improves resilience, neuroplasticity, and recovery. Dr. Guarente shares insider strategies from decades of functional medicine research, including nootropics, targeted supplements, fasting protocols, and diet adjustments from carnivore to Mediterranean that can shift your metabolism toward longevity. Dave and Dr. Guarente explore advanced biohacks like cold therapy, sleep optimization, and ketosis, plus how to balance these interventions with your genetics, lifestyle, and health goals. You'll also hear about the surprising role of homocysteine in brain aging, how to use lab testing to guide your longevity plan, and why resilience is the ultimate measure of health. You'll learn: • How emotional repression affects brain function, metabolism, and decision-making • Tools for nervous system regulation and emotional healing that drive high performance • Why most people fail without emotional intelligence and internal safety • How somatic awareness can optimize your energy, focus, and relationships • The science of fear, trauma release, and how to turn discomfort into growth • How to coach yourself out of stress, shame, and negative self-talk Whether you want to sharpen your brain, protect your heart, or upgrade your energy systems, this is a masterclass in smarter not harder biohacking for a longer, higher-performing life.Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Episodes are released every Tuesday, Thursday, and Friday (audio-only) where Dave asks the questions no one else dares, and brings you real tools to become more resilient, aware, and high performing. Keywords: NAD+ supplementation, Sirtuin activation, DNA methylation clocks, Biological age testing, Mitochondrial biogenesis, Epigenetic reprogramming, Pterostilbene benefits, Nicotinamide riboside (NR), Nicotinamide mononucleotide (NMN), Homocysteine reduction, Oxidative stress repair, Superoxide dismutase (SOD) activation, Functional medicine longevity, Healthspan optimization, Resveratrol bioavailability, Menopause mitochondrial support, Phenylbutyrate and protein folding, High-fat diet longevity studies, Neurodegenerative disease biohacking, INCHIANTI aging study Thank you to our sponsors! Screenfit | Get your at-home eye training program for 40% off using code DAVE https://www.screenfit.com/dave. Timeline | Head to https://www.timeline.com/dave to get 10% off your first order. Zbiotics | Go to https://zbiotics.com/DAVE for 15% off your first order. Resources: • Elysium Website. Use code ‘UPGRADE25' for 25% off the first month of a monthly subscription to any Elysium supplement: https://www.elysiumhealth.com/ • Dave Asprey's Website: https://daveasprey.com • Danger Coffee: https://dangercoffee.com/DAVE15 • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Introduction to NAD & Sirtuins 0:59 — Intro 7:04 — Animal vs Human Aging Studies 10:07 — Discovery of Sirtuins 14:43 — NAD's Role in Aging 15:34 — Resveratrol vs Pterostilbene 23:13 — Timing NAD Supplementation 36:34 — Diet & Lifestyle Factors 50:05 — Elysium's Basis & Signal 1:00:03 — Future Clinical Trials 1:05:14 — Psychology of Aging & Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Medical Misdiagnosis and Pneumonia. My Personal Experience.
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Rosemary on Inflammation: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Aloe Vera on Gut Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Quality of Life – The Purpose of Truth Freedom Health
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Neem on Skin Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Tulsi on Immune Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Moringa on Men's Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about The Power of Home. The Community of Truth Freedom Health®
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Ginseng on Hair Loss: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Green Tea on Eye Health: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about The Power Within Us – Women Leading the Movement for Truth Freedom Health®
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Amla on Aging: A Whole Systems Approach
In this interview, Dr.SHIVA Ayyadurai, MIT PhD, Inventor of Email, Scientist, Engineer and Candidate for President, Talks about Turmeric on Alzheimer's disease: A Whole Systems Approach
Are the AI models you use today imposters?Please watch the intro video we did before this: https://www.youtube.com/watch?v=o1q6Hhz0MAgIn this episode, hosts Dr. Tim Scarfe and Dr. Duggar are joined by AI researcher Prof. Kenneth Stanley and MIT PhD student Akash Kumar to discuss their fascinating paper, "Questioning Representational Optimism in Deep Learning."Imagine you ask two people to draw a perfect skull. One is a brilliant artist who understands anatomy, the other is a machine that just traces the image. Both drawings look identical, but the artist understands what a skull is—they know where the mouth is, how the jaw works, and that it's symmetrical. The machine just has a tangled mess of lines that happens to form the right picture.An AI with an elegant representation, has the building blocks to generate truly new ideas.The Path Is the Goal: As Kenneth Stanley puts it, "it matters not just where you get, but how you got there". Two students can ace a math test, but the one who truly understands the concepts—instead of just memorizing formulas—is the one who will go on to make new discoveries.The show is a mixture of 3 separate recordings we have done, the original Patreon warmup with Tim/Kenneth, the Tim/Keith "Steakhouse" recorded after the main interview, then the main interview with Kenneth/Akarsh/Keith/Tim. Feel free to skip around. We had to edit this in a rush as we are travelling next week but it's reasonably cleaned up. TOC:00:00:00 Intro: Garbage vs. Amazing Representations00:05:42 How Good Representations Form00:11:14 Challenging the "Bitter Lesson"00:18:04 AI Creativity & Representation Types00:22:13 Steakhouse: Critiques & Alternatives00:28:30 Steakhouse: Key Concepts & Goldilocks Zone00:39:42 Steakhouse: A Sober View on AI Risk00:43:46 Steakhouse: The Paradox of Open-Ended Search00:47:58 Main Interview: Paper Intro & Core Concepts00:56:44 Main Interview: Deception and Evolvability01:36:30 Main Interview: Reinterpreting Evolution01:56:16 Main Interview: Impostor Intelligence02:11:15 Main Interview: Recommendations for AI ResearchREFS:Questioning Representational Optimism in Deep Learning:The Fractured Entangled Representation HypothesisAkarsh Kumar, Jeff Clune, Joel Lehman, Kenneth O. Stanleyhttps://arxiv.org/pdf/2505.11581Kenneth O. Stanley, Joel LehmanWhy Greatness Cannot Be Planned: The Myth of the Objectivehttps://amzn.to/44xLaXKOriginal show with Kenneth from 4 years ago:https://www.youtube.com/watch?v=lhYGXYeMq_EKenneth Stanley is SVP Open Endedness at Lila Scienceshttps://x.com/kenneth0stanleyAkarsh Kumar (MIT)https://akarshkumar.com/AND... Kenneth is HIRING (this is an OPPORTUNITY OF A LIFETIME!)Research Engineer: https://job-boards.greenhouse.io/lila/jobs/7890007002Research Scientist: https://job-boards.greenhouse.io/lila/jobs/8012245002TRANSCRIPT:https://app.rescript.info/public/share/W_T7E1OC2Wj49ccqlIOOztg2MJWaaVbovTeyxcFEQdU