Podcasts about buck institute

What do aviation, AI, parenting, and longevity have in common? Blair LaCorte. In this fast-paced episode, Episode 243 of the Fit Father Project Podcast, he shares with Dr. Anthony Balduzzi the biggest lessons from his high-performance life — and how we can all build a stronger body, mind, and purpose. Together, they explore the powerful idea that safety — both physical and emotional — is the foundation for longevity, authentic living, and effective parenting. Blair shares how formative childhood experiences shaped his entrepreneurial spirit, why midlife transitions are deeply necessary, and how self-love is one of the highest acts of love for your children.Blair explains how your parasympathetic nervous system — the “rest and digest” network — underpins your mental, physical, and emotional well-being. He emphasizes the vital role of feeling safe, connected, and curious in both health and personal evolution. His advice? Move every hour, sleep according to your chronotype, get sunlight in your eyes first thing in the morning, and start each day with intention. From daily mantras to longevity science from the Buck Institute, Blair's practical wisdom is packed with insights.The conversation also dives into actionable tips for parents on creating resilient, curious, and emotionally stable kids — without overprotecting them. Blair's candid reflection on failure, identity, and the modern health landscape is both refreshing and empowering. Whether you're looking to optimize your body, reconnect with your purpose, or better guide your children in the AI age, this episode delivers.Key TakeawaysChildhood wiring shapes lifelong behaviorSelf-love is essential for effective parentingAuthenticity is the key to a regret-free lifeSafety regulates the parasympathetic nervous systemYour nervous system is the root of health spanFrequent movement trumps long workoutsMorning sunlight resets your biological clockDaily mantras shift your brain's focusSitting is the new smoking — get up hourlyConnection is the #1 longevity multiplierFood is the most important input for your healthKids need a safe place to fail and growRandom acts of kindness heal both giver and receiverLearn More about Blair LaCorte:Websites: https://ppemastermind.com/ https://www.mastermindinnovate.com/ LinkedIn: https://www.linkedin.com/in/blair-lacorte-68084/YouTube: https://www.youtube.com/channel/UCTSlr8fDtSu4Ev_hF6tyqDwBiographical Information on Blair LaCorte:Blair LaCorte is a dynamic business executive who after being raised by two entrepreneurs has taken a path less traveled, unless of course you were Forrest Gump! His career spans numerous industries such as entertainment, aviation, AI, technology, aerospace, consulting, investing and military logistics. Renowned for his insatiable curiosity, collaborative spirit, passionate oratorical skills and competitive drive, Blair consistently strives to make a positive contribution and impact in all his endeavors.For Credibility: Blair has held CEO or “C” level strategy or operating roles in companies such PRG (largest live entertainment production company), XOJET/Vista (largest private aviation company), TPG (one of largest PE firms), Autodesk (largest CAD SW company), and Sun Microsystems / Oracle...

If you’re worried about memory loss or have a family history of Alzheimer’s, this episode is a must-listen. Angela sits down with world-renowned neurologist and author Dr. Dale Bredesen to unpack the groundbreaking science behind Alzheimer’s prevention and reversal—even if you carry the APOE4 gene. With over 30 years of research, Dr. Bredesen shares how to optimise your brain health through metabolic flexibility, inflammation control, and personalised interventions. In this powerful and deeply personal episode, Angela also opens up about her own genetic risk and experience caring for her mum with Alzheimer’s. They explore why cognitive decline is not inevitable and how Dr. Bredesen’s new book, The Ageless Brain, is putting the power back into your hands. Whether you're 35 or 75, the steps to preserve your cognition start now—and the tools have never been more accessible. KEY TAKEAWAYS: Alzheimer’s Is Preventable and Reversible: Dr. Bredesen explains how addressing root causes like inflammation, metabolic dysfunction, and toxicity can stop and even reverse cognitive decline. Perimenopause and Brain Fog: Oestrogen loss affects brain energy metabolism, making perimenopausal women more vulnerable to cognitive decline. Your Brain Runs on Supply & Demand: Cognitive health depends on supporting your brain’s high energy needs while reducing inflammatory load and toxic exposure. Check Your Cognitive Biomarkers Early: Blood markers like P-Tau217, GFAP, and A-beta42 can reveal risk decades before symptoms appear. Lifestyle = Medicine: Sleep quality, insulin sensitivity, resistance training, brain stimulation, and even stress reduction all play a critical role. GLP-1s and Alzheimer’s Risk: While popular for weight loss, these drugs may negatively impact cognition in some people—especially APOE4 homozygotes. TIMESTAMPS AND KEY TOPICS:0:00 – Introduction 6:48 – Pathogens, toxins, and the real cause of Alzheimer’s 13:32 – Menopause, oestrogen, and female brain vulnerability 24:05 – Judy’s story: reversing cognitive decline for 13+ years 32:18 – Most common risky behaviours for brain degeneration 42:21 – Best exercises for insulin sensitivity and cognition 51:10 – Supplements that protect brain structure & function 54:22 – How to use The Ageless Brain as a practical guide 58:45 – Final thoughts + where to learn more from Dr. Bredesen VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend A BIG thank you to our sponsors who make the show possible: Get 20% off the Creatine I love at trycreate.co/ANGELA20, and use code ANGELA20 to save 20% on your firsts order. Brain Boost: Try Neuro Regenerate at lvluphealth.com/angela and use code ANGELA15 to save 15% ABOUT THE GUEST Dale Bredesen, M.D. is an expert in the mechanisms of neurodegenerative diseases such as Alzheimer's disease. He is a graduate of Caltech, and received his MD from Duke University Medical Center. His career has included serving as Chief Resident in Neurology at the University of California, San Francisco, and served as a NIH Postdoctoral Fellow. His faculty position included working at UCSF, UCLA, and the University of California, San Diego. He was the director of the Program on Aging at the Burnham Institute. He was the founding President and CEO of the Buck Institute. He has developed a new therapeutic approach to treating Alzheimer's disease. He is the author of The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline. Dr Dale Bredesen’s latest book: The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime - https://amzn.eu/d/gdrjKQm https://www.apollohealthco.com/ https://www.instagram.com/drdalebredesen/ https://www.facebook.com/drdalebredesen/ ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast. This Podcast has been brought to you by Disruptive Media. https://disruptivemedia.co.uk/

In this episode of Ageless Athlete, we dive into the metabolic engine room with Dr. Brianna Stubbs—world-class endurance athlete and leading researcher at the Buck Institute for Research on Aging. Brianna bridges the worlds of elite performance and cutting-edge science, specializing in how ketones, fasting, and metabolic flexibility can shape our ability to recover, sustain energy, and age well.This isn't about dieting fads or silver bullets—it's about understanding how your body fuels itself, and how those energy pathways evolve over time. Whether you're an endurance athlete or someone simply trying to stay strong into your 40s, 50s, and beyond, Brianna's insights will give you a fresh way to think about performance and longevity.

This week on the WHOOP Podcast, WHOOP Founder and CEO Will Ahmed sits down with WHOOP SVP of Research, Algorithms, and Data Emily Capodilupo to break down an exciting new feature: Healthspan with WHOOP Age and Pace of Aging. Developed in collaboration with the Buck Institute for Research on Aging, WHOOP has created the ultimate longevity metric to understand your physiological age, measuring varying components of sleep, strain, and fitness. Will and Emily introduce the 9 metrics that make up your WHOOP Age and Pace of Aging: sleep consistency, hours of sleep, time in heart rate zones 1-3 and 4-5, strength training, steps, VO₂ Max, resting heart rate, and lean body mass. Healthspan with WHOOP Age and Pace of Aging is now available with WHOOP Peak and WHOOP Life memberships. Healthspan is not available for users under the age of 18.(00:00) What is Healthspan?(8:27) WHOOP Partnership with the Buck Institute(9:30) Why Healthspan? What does WHOOP measure to create this metric? (13:57) WHOOP Age and Pace of Aging (19:16): The 9 Metrics of Healthspan (19:46) Sleep Consistency (23:22) Hours of Sleep(27:28) Time in HR Zones 1-3 and HR Zones 4-5(31:39) Strength Training(35:31) Steps(38:28) VO₂ Max(41:15) Resting Heart Rate(44:14) Lean Body Mass(45:37) The Healthspan Algorithm(48:28) Heathspan Page & The Health Tab(49:12) Coaching people toward a healthier and longer life Support the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Instagram TikTok X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn

BUFFALO, NY — April 29, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 3, on March 20, 2025, titled “Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP).” Researchers, led by first author Sudipta Bar and corresponding authors Amit Sharma and Pankaj Kapahi from the Buck Institute for Research on Aging, have found that the enzyme ADAM19 plays an important role in regulating aging in cells and inflammation in the gut. Their study shows that blocking ADAM19 reduced gut damage and inflammation in fruit flies, mice, and human cells. This discovery points to a new possible way to treat gut disorders related to aging by reducing the harmful signals from senescent (aging) cells. As individuals age, DNA damage can lead to the accumulation of senescent cells, contributing to tissue damage. These are cells that stop dividing and release harmful inflammatory substances called the senescence-associated secretory phenotype (SASP). In this study, researchers used fruit flies to search for genes involved in radiation-related gut damage. They identified a gene called meltrin, which is similar to human ADAM19. When meltrin was turned off, the flies had less gut leakage, less inflammation, and fewer signs of cellular aging. “Through an unbiased genome-wide association study (GWAS) utilizing 156 strains from the Drosophila Genetic Reference Panel (DGRP), we identified meltrin (the drosophila orthologue of mammalian ADAM19) as a potential modulator of the senescence-associated secretory phenotype (SASP).” To test if these results applied beyond flies, the team inhibited ADAM19 in mice using a drug called batimastat. Mice treated with the drug after chemotherapy exposure had stronger gut barriers and lower levels of inflammatory markers. The findings extended to human cell cultures, where ADAM19 inhibition reduced signs of cellular aging, including the expression of SASP proteins and β-galactosidase, a classic aging marker. Importantly, this approach does not kill aging cells like many 'senolytic' therapies but instead reduces the harmful substances they release, making it a potential "senomorphic" strategy. The study also showed that ADAM19 helps release certain SASP proteins by cutting them at the cell surface, suggesting a direct role in regulating inflammatory signals. Through proteomic analysis, the team identified 12 SASP proteins that were significantly reduced when ADAM19 was blocked. Many of these proteins are linked to inflammation, immune response, and tissue remodeling in diseases such as inflammatory bowel disease and Crohn's disease. This connection underlines the relevance of the findings for treating chronic gut disorders in aging populations. By targeting ADAM19, researchers may have found a new way to protect gut health and lower inflammation caused by aging cells. This study offers a promising path for creating treatments that maintain healthy tissues without having to destroy aging cells, which could benefit people with gut damage related to aging or medical treatments. DOI - https://doi.org/10.18632/aging.206224 Corresponding authors - Amit Sharma - amit.sharma@sens.org, and Pankaj Kapahi - pkapahi@buckinstitute.org Video short - https://www.youtube.com/watch?v=dRfxQ20O2fQ Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​. MEDIA@IMPACTJOURNALS.COM

Entrepreneurship and Longevity aren't often discussed in the same sentence, but that's exactly where the future of high-performance leadership is headed. In a time when business moves faster than ever and disruption is the norm, those who sustain success aren't just building companies—they're building resilience from the inside out. Blair LaCorte, Managing Director of LaCorte Ventures, brings a rare perspective on what it takes to lead over the long term. His career spans executive roles across aerospace, artificial intelligence, tech, entertainment, defense, and private equity. From startup growth to IPOs and complex mergers, LaCorte has not only built companies—he's rebuilt them, restructured them, and prepared them for sustainable scalability. It's this unique lens that positions him as a standout voice in the intersection of entrepreneurship and longevity. LaCorte's approach to leadership is rooted in operational excellence, but it's also deeply informed by neuroscience, systems thinking, and human performance. He doesn't just advise organizations—he helps rewire how leaders think about health, decision-making, and the environments they operate in. The topic of longevity often focuses on lifespan. LaCorte challenges that by shifting the conversation to healthspan—how long a leader can operate at their peak, not just how long they live. For entrepreneurs, executives, and founders constantly managing pressure, stress, and uncertainty, this distinction is critical. Peak performance isn't about grinding harder. It's about creating a foundation that allows for clarity, recovery, and sustainability. Throughout his career, LaCorte has worked with over 100 companies as an investor, board member, and adviser. His experience includes leading major transformations and pioneering innovation in fields that rarely cross paths—an advantage he attributes to his curiosity and pattern recognition across industries. From co-founding mastermind networks to helping companies navigate explosive growth, his perspective on entrepreneurship and longevity is not theoretical—it's hard-earned. What sets LaCorte apart is his commitment to systems-level thinking. He views business as a sport—one that demands preparation, precision, and performance, but also recovery, connection, and alignment. His emphasis on building value-based teams, fostering deep connections, and operating with authenticity isn't just cultural advice—it's a competitive edge. This mindset extends into how LaCorte advises leaders to manage themselves. It's not just about productivity hacks or strategic frameworks. It's about building internal infrastructure—mental, emotional, and physical—that allows leaders to make better decisions, manage complexity, and stay adaptable over time. Entrepreneurship and longevity, in his view, are inextricably linked. Without personal optimization, professional growth eventually hits a ceiling. LaCorte's leadership philosophy also underscores the power of community. He's a firm believer in the role of masterminds, not just as a tool for knowledge exchange, but as a critical piece of human connection. In an age of information overload, it's not about accessing more data—it's about curating the right voices, having trusted peers who challenge your assumptions, and staying accountable to continuous growth. His work in launching the Pinnacle Performers Elite Mastermind reflects this belief. By bringing together leaders from diverse industries, LaCorte facilitates a space where pattern recognition, vulnerability, and innovation intersect. These environments are engineered for growth—not just in revenue, but in mindset and mission. The conversation around entrepreneurship and longevity is only becoming more urgent. As business leaders face rising demands and ever-faster innovation cycles, the ones who thrive will be those who build with endurance in mind. It's no longer enough to scale fast. It's about scaling with intention, clarity, and care—for your business, your people, and yourself. Blair LaCorte is part of a new wave of business thinkers who recognize that long-term impact doesn't come from burnout. It comes from balance, recovery, and relentless alignment to purpose. He's lived it, led it, and continues to guide others to do the same. Watch the full episode on YouTube. Don't miss future episodes that feature powerful conversations and actionable insights from today's top business minds. Join Fordify LIVE! Every Wednesday at 11AM Central on your favorite social platforms and catch The Business Growth Show Podcast every Thursday for a weekly dose of business growth wisdom. About Blair LaCorte Blair LaCorte is a transformational leader, entrepreneur, and strategic advisor with a career that spans executive roles across aerospace, AI, tech, defense, entertainment, and private equity. As the Managing Director of LaCorte Ventures, he brings decades of experience guiding companies through rapid growth, operational restructuring, mergers, IPOs, and strategic exits. With a passion for leadership, longevity, and elite performance, Blair is known for applying cross-industry insights to solve complex business challenges. He has served as an investor or advisor to more than 100 companies, helping executive teams unlock growth and build scalable, sustainable strategies. His leadership style combines high-level strategy with a deep understanding of human behavior, systems thinking, and culture. Blair has been recognized as a NASA Innovator of the Year and is a scheduled Virgin Galactic astronaut. He also serves as Vice Chair of the Buck Institute for Research on Aging, where he helps advance science-based approaches to optimizing healthspan and vitality. As the founder of Pinnacle Performers Elite (PPE) Mastermind and MastermindInnovate.com, Blair curates high-impact environments for top-tier entrepreneurs and business owners to connect, grow, and lead with clarity. To explore Blair's latest work in leadership, longevity, and high-performance strategy, visit MastermindInnovate.com for thought leadership and resources, and PPEMastermind.com to learn more about his exclusive mastermind community for elite entrepreneurs. About Ford Saeks Ford Saeks is a Business Growth Accelerator who has helped generate over a billion dollars in sales for organizations ranging from startups to Fortune 500s. With more than 20 years of experience, he's redefined what it means to drive success—combining strategic marketing, innovation, and real-world business acumen. As the President and CEO of Prime Concepts Group, Inc., Ford helps businesses attract loyal customers, expand brand visibility, and improve performance at every level. He's founded over ten companies, authored five books, earned three U.S. patents, and received numerous industry accolades for his work in marketing, leadership, and entrepreneurship. A trailblazer in digital innovation, Ford is also an expert in AI prompt engineering, training businesses to use tools like ChatGPT to create high-impact content and elevate customer engagement. He recently shared his expertise on stage at the “Unleash AI for Business Summit,” where he spoke on the role of AI in transforming operations, marketing, and the customer experience. To learn more, visit ProfitRichResults.com and watch his business TV show at Fordify.tv.

In this episode, I'm joined by Dr. Dale Bredesen, a true pioneer in Alzheimer's research and functional medicine. Together, we dive into groundbreaking advancements in the world of neurodegenerative diseases, with a special focus on the exciting breakthroughs in detecting and potentially reversing Alzheimer's and other related conditions. Dr. Bredesen sheds light on the new disease mechanisms and innovative blood tests that are changing the game, showing us that cognitive decline isn't something we simply have to accept. We also explore his integrative approach to combating Alzheimer's, which includes lifestyle modifications, early detection, and a holistic strategy for better brain health. This conversation is packed with hope and real strategies for a future where Alzheimer's doesn't have to be inevitable. Key Takeaways: New Era of Research: Alzheimer's and similar neurodegenerative diseases are not death sentences, thanks to innovative research and new treatment protocols that emphasize early detection and intervention. Significance of Gut Health: Investigations reveal that gut microbiota and inflammation are crucial risk factors in cognitive decline, underscoring the importance of gut health in preventing Alzheimer's. Role of Lifestyle Changes: Diet, exercise, sleep, and stress management are integral to maintaining brain health and can significantly influence the progression of neurodegenerative diseases. Advance in Diagnostics: Cutting-edge blood tests such as P Tau217 and brain scans can detect early signs of Alzheimer's up to 20 years prior to diagnosis, offering opportunities for preemptive action. The Power of Personalized Medicine: Individualized protocols based on genetic testing, like assessing APOE status, are pivotal in developing effective prevention and treatment strategies for cognitive disorders. More About Dr. Dale Bredesen: Dr. Dale Bredesen, M.D., is a globally recognized expert in neurodegenerative diseases, particularly Alzheimer's disease. With a background that includes graduating from Caltech and earning his M.D. from Duke University Medical Center, Dr. Bredesen's career is marked by groundbreaking research and clinical expertise. He completed his residency as chief resident in neurology at UCSF and further honed his skills at Nobel laureate Stanley Prusiner's lab at UCSF as an NIH postdoctoral fellow. Dr. Bredesen's academic career includes faculty positions at prestigious institutions like UCSF, UCLA, and UC San Diego. As the founding president and CEO of the Buck Institute for Research on Aging, he spearheaded pioneering work in the study of aging and neurodegenerative diseases. Currently, he serves as the chief medical officer of MPI Cognition, where he continues his innovative research and efforts to combat Alzheimer's and related conditions. Dr. Bredesen's expertise and leadership have made him a key figure in the field, with a focus on integrative approaches to prevent and reverse cognitive decline. His contributions are reshaping our understanding of neurodegenerative diseases, offering new hope for those affected by them. Website Instagram Take a Cognitive Assessment here: https://www.apollohealthco.com/know-your-cq/ Get a brain scan: https://getabrainscan.com/ KetoFLEX 12/3: https://www.trifectanutrition.com/apollohealthpartner Connect with me! Website Instagram Facebook YouTube   This episode is sponsored by Professional Co-op®, where clinicians gain exceptional access to industry-leading lab services without the hefty price tag—since 2001, they've been redefining what efficient, patient-focused support looks like. Imagine no hidden fees, no minimums, and only paying for completed tests. Experience lab services that not only meet but also exceed your expectations. Join the co-op trusted by countless licensed clinicians nationwide. Visit www.professionalco-op.com to learn more! This episode is also made possible by Functional Medicine University. FMU is a fully online, self-paced training program in functional medicine, founded in 2006 by Dr. Ron Grisanti. With students in all 50 U.S. states and 68 countries globally, FMU has become a cornerstone in advanced clinical education for healthcare practitioners. The curriculum is led by Dr. Grisanti, alongside contributions from over 70 distinguished medical experts on FMU's advisory board. Graduates earn the prestigious Certified Functional Medicine Practitioner (CFMP®) credential upon completion. FMU is also a nationally approved provider of continuing education for a wide range of licensed professionals, including MDs, DCs, DOs, NDs, acupuncturists, PAs, NPs, nurses, dietitians, pharmacists, and dentists. Whether you're looking to expand your clinical knowledge or bring a functional approach to your practice, FMU offers the tools, guidance, and certification to help you thrive. Visit www.functionalmedicineuniversity.com to learn more!

NextMed Health in a healthtech and biotech conference exploring the most forward thinking ideas and topics in healthcare. Taking place in San Diego, a four day programme covered topics such as latest developments in AI, aging, increasing lifespan and longevity, addressing mental health and exercise through VR, and more. In this special episode of Faces of digital health, Gary Monk and Tjasa Zajc reflect on the key findings through additional discussions with: Anthony Chang, MD, MBA, MPH, Founder, AIMed. Chief Intelligence & Innovation Office, Children's Hospital of Orange County  Daniel Kraft, MD,  Founder & Chair, NextMed Health. Bayo Curry-Winchell, MD, Founder, Beyond Clinical Walls. Urgent Care Medical Director, Saint Mary's Health Network Steven Brown, AI developer, Coder, founder, investor, filmmaker Jennifer Garrison, PhD, Professor, Buck Institute. Co-Founder & Director, ProductiveHealth.org Eric Topol, MD,  Founder and Director, Scripps Research Translational Institute What's covered:

Send us a textIn this episode of the Hotflash inc Podcast, GenX journalist Ann Marie McQueen sits down with Dr Deena Emera, an evolutionary geneticist, senior scientist at the Buck Institute's Buck Center for Healthy Aging in Women, and author of A Brief History of the Female Body: An Evolutionary Look at How and Why the Female Form Came to Be.Dr Emera's research focuses on the genetic basis of reproductive longevity in mammals, and in this fascinating discussion, she breaks down the evolution of menopause, why female bodies age the way they do, and what modern science is uncovering about ovarian health and longevity.If you've ever wondered why menopause exists, how it evolved, and whether science will ever be able to delay or even prevent it, this episode is for you.Highlights: Understanding evolutionary biology (it's not boring, promise)The evolutionary mystery of menopauseWhat animals do go through menopause?Why all women didn't used to die at 50 (and what actually happened)How modern life has changed menopauseWhy Dr Emera needs bowhead whale ovariesCan we really end menopause?The truth about the Grandmother HypothesisQuote:"Menopause itself isn't surprising – if you live long enough, you will run out of eggs. What's unique about humans is that we have such a long post-reproductive life stage. That's the real mystery we need to solve." – Dr Deena EmeraWhere to find Dr Emera:Instagram: @deenaemeraLinkedIn: Deena EmeraBuy her book: A Brief History of the Female Body – Available on AmazonThank you to our sponsor Timeline Nutrition Mitopure supports cellular energy and longevity—now available with a 10% discount! Visit timeline.com/HOTFLASH and use the code HOTFLASH to claim your offer!DisclaimerThis podcast is for informational purposes only and is not intended as medical advice. Always consult your healthcare provider before making any health-related decisions.Join the Hotflash inc perimenoposse: Web: hotflashinc.comNewsletter: Hotflash inc. on SubstackTikTok: @hotflashincInstagram: @hotflashincX: @hotflashinc Episode website: Hotflashinc Listen on: Apple Podcasts | Spotify | Google Podcasts | YouTube | Substack See hotflashinc.com/privacy-policy for privacy information

Your brain isn't just wired—it's mapped biochemically, and those signals may hold the key to longevity. In this episode, Dr. Graham Taylor sits down with Dr. Jennifer Garrison, a leading researcher at the Buck Institute for Research on Aging and an adjunct assistant professor of gerontology. Dr. Garrison's groundbreaking work focuses on neuropeptides—the brain's chemical messengers—and their powerful influence on aging, behavior, and reproductive decline. Using cutting-edge techniques, she investigates how neuropeptide shifts impact longevity and explores the intricate brain-ovary connection, a key yet often overlooked factor in women's health. A recipient of prestigious honors, including the Alfred P. Sloan Research Fellowship, Dr. Garrison is at the forefront of research aimed at unlocking new interventions for age-related conditions. Join us as we dive into her pioneering discoveries and discuss how understanding these biochemical signals could transform our approach to aging—especially for women's health and longevity.   For more information about Dr. Jennifer Garrison and Garrison Lab, please visit: https://garrisonlab.com For more information about Productive Health and the Productive Health Global Consortium, please visit: https://gcrle.org If you would like to support the Global Consortium for Reproductive Longevity and Equality, please consider donating: https://secure.qgiv.com/for/centerforhealthyaginginwomen/ Connect with Buck Institute for Research on Aging on Instagram at: https://www.instagram.com/buckinstituteforaging/ Connect with Buck Institute for Research on Aging on Linkedin at: https://www.linkedin.com/company/buck-institute-for-research-on-aging/ Connect with Buck Institute for Research on Aging on YouTube at: https://www.youtube.com/channel/UClKDVsCWOcAxUXgVyaIGVdw

Aging Research in Women takes center stage as Dr. Jennifer Garrison uncovers the overlooked reality that ovaries age faster than any other organ. This rapid aging, occurring at a rate two and a half times quicker than other tissues, significantly impacts women's health spans. From heightened cardiovascular risks to osteoporosis, the consequences of accelerated ovarian aging are vast, especially post-menopause. Yet, ovarian health research has long suffered from severe underfunding. At the Buck Institute for Research on Aging, Garrison's work aims to address this deficit by understanding the brain-ovary signaling axis, which she believes is key to promoting healthier aging for women. Sponsored by Qualia Senolytic: https://qualialife.com/podcastoffer. Use code podcast when you shop Qualia Senolytic for 15% off your order. Get in touch. Instagram: https://www.instagram.com/qualialife. Facebook: https://www.facebook.com/qualialife. Email: support@qualialife.com.

Jennifer Garrison, PhD, is Co-Founder and Director of the Global Consortium for Reproductive Longevity and Equality (GCRLE) and an Assistant Professor at the Buck Institute for Research on Aging. She also holds appointments in the Department of Cellular and Molecular Pharmacology at the University of California, San Francisco (UCSF) and the Leonard Davis School of Gerontology at the University of Southern California (USC). She is a passionate advocate for women's health and is pioneering a new movement to advance science that is focused on female reproductive aging. Her lab studies the role of mind-body communication in systemic aging, and how changes in the conversation between the ovary and brain during aging may lead to the onset of reproductive decline in females.About Foresight InstituteForesight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.Allison DuettmannThe President and CEO of Foresight Institute, Allison Duettmann directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, alongside Fellowships, Prizes, and Tech Trees. She has also been pivotal in co-initiating the Longevity Prize, pioneering initiatives like Existentialhope.com, and contributing to notable works like "Superintelligence: Coordination & Strategy" and "Gaming the Future".Get Involved with Foresight:Apply to our virtual technical seminars Join our in-person events and workshops Donate: Support Our Work – If you enjoy what we do, please consider this, as we are entirely funded by your donations!Follow Us: Twitter | Facebook | LinkedInNote: Explore every word spoken on this podcast through Fathom.fm, an innovative podcast search engine. Hosted on Acast. See acast.com/privacy for more information.

In this episode, Andrea Donsky, a nutritionist, menopause educator, published menopause researcher, and co-founder of WeAreMorphous.com, interviews Dr. Bredesen, the founding president of the Buck Institute for Research on Aging; he has published over 230 papers and achieved the first reversal of cognitive decline in Alzheimer's patients using a precision medicine protocol. Together, they explore cognitive health during perimenopause and menopause with Dr. Dale Bredesen, a pioneering expert in neurodegenerative diseases.Key Topics:Understanding cognitive changes during perimenopause and menopauseThe revolutionary Brain Scan Blood Test for cognitive profilingHow bioidentical hormone therapy (BHRT), nutrition, exercise, and sleep impact brain healthThe connection between dental health and brain microbiomeImpact of toxins on cognitive declineThe role of genetics (APOE states) in cognitionDeep sleep's importance for detoxing the glymphatic systemUnderstanding Heart Rate Variability (HRV) and stress managementResources Mentioned:Dr. Bredesen's RECODE Program: https://training.apollohealthco.com/courses/ReCODE-2-0 (Use code: MENOPAUSE200)Brain Scan Test: https://www.apollohealthco.com/brainscan/Free Cognitive Quotient Test: https://www.apollohealthco.com/know-your-cq-free/APOE Information: https://www.apoe4.info/Send us a text ✅ Fill out our surveys Support our SPONSORS: Qualia https://bit.ly/42mtvmx CODE MORPHUS15 BEAM Minerals https://bit.ly/41DCG1w Code MORPHUS EnergyBits https://bit.ly/49f05YV Code MORPHUS Livon: https://bit.ly/3EjrcGG CODE MORPHUS Order 1 carton of Lypo-Spheric® Vitamin C at LivOnLabs.com & get 1 carton of B Complex Plus FREE ($56 value) just by adding both products to the cart Timeline: timeline.com/morphus CODE MORPHUS

In this episode of 'The Wisdom Of' Show, host Simon Bowen explores groundbreaking research on Alzheimer's disease with Dr. Dale Bredesen, renowned neurodegenerative scientist and CEO of the Buck Institute for Age Research. From challenging medical paradigms to developing revolutionary treatments, Dr. Bredesen shares crucial insights on preventing and reversing neurodegenerative diseases, along with valuable lessons on innovation and resilience in the face of established opposition.Ready to unlock your leadership potential and drive real change? Join Simon's exclusive masterclass on The Models Method. Learn how to articulate your unique value and create scalable impact: https://thesimonbowen.com/masterclassEpisode Breakdown 00:00 Introduction and background 05:13 Challenging conventional wisdom on Alzheimer's 10:46 The 30-year research journey 18:58 Key biomarkers and prevention strategies 25:44 Common contributors to neurodegeneration 33:44 Facing opposition in scientific community 38:35 Balancing hope with reality 45:13 Future implications and conclusionAbout Dr. Dale Bredesen Dr. Dale Bredesen is a pioneer in neurodegenerative disease research and CEO of the Buck Institute for Age Research. With over 30 years of research experience and 200+ peer-reviewed papers, he has revolutionized our understanding of Alzheimer's disease. His groundbreaking work through the ReCODE Protocol™ has demonstrated that neurodegenerative diseases are not only preventable but potentially reversible. As a prodigious innovator in medicine with numerous patents, Dr. Bredesen's research has shifted scientific consensus from viewing these conditions as inevitable to treating them as optional and manageable diseases.Through his work at the Buck Institute For Age Research and Apollo Health, Dr. Bredesen continues to advance our understanding of neurological health while helping patients achieve unprecedented recovery from cognitive decline. His dedication to challenging established medical paradigms has opened new possibilities for treating and preventing neurodegenerative diseases.Connect with Dr. Dale BredesenFacebook: https://www.facebook.com/drdalebredesen/LinkedIn: https://www.linkedin.com/in/dale-bredesen-2ab0651/Instagram: https://www.instagram.com/drdalebredesen/Twitter: https://twitter.com/DrDaleBredesenWebsite: https://www.apollohealthco.com/dr-bredesen/About Simon Bowen Simon has spent over two decades working with influential leaders across complex industries. His focus is on elevating thinking in organizations, recognizing that success is directly proportional to the quality of thinking and ideas within a business. Simon leads the renaissance of thinking through his work with global leaders and organizations.Connect with SimonLinkedIn: https://www.linkedin.com/in/simonbowen-mm/Instagram: https://www.instagram.com/officialsimonbowen/Website:

How do we create schools where students actually want to learn? Meet Kapono Ciotti, an educator working to transform schools from teacher-centered stages to student-led learning environments. Drawing from his experiences in progressive education systems, Ciotti shares practical strategies for letting students take the lead in their learning journey. His innovative approaches and the What School Could Be framework offer a roadmap for educators ready to trust students with real ownership of their education.IN THIS EPISODE, WE DISCUSS:The shift from industrial-age schooling to student-led learningBuilding genuine learning communities in schoolsThe role of AI in transforming educationCreating schools where students want to beNew frameworks for measuring educational successRESOURCES AND LINKS MENTIONED IN THIS EPISODE:Connect with Kapono and What Schools Could Be on LinkedIn, Instagram, the WSCB community, and by visiting www.whatschoolscouldbe.orgWhat Decade Is Your School Preparing Students For? Take the survey and find out: www.whatschoolcouldbe.org/surveyVisit www.principledlearning.org to learn more about Jennifer D. Klein and her workLearn more about the Rebel Project Literacy Curriculum, a fully integrated literacy and project based learning curriculum, at  projectup.us or inkwire.co/rplc Get your copy of Rebel Educator: Create Classrooms Where Impact and Imagination MeetLearn more about Rebel Educator, explore our professional development opportunities for educators and students, and check out our project library.Visit us at UP Academy to learn more about our personalized and inclusive learning environment.Connect with Tanya and UP Academy on LinkedIn, Facebook, and Instagram and learn more about her journey here.GUEST BIO:Kapono Ciotti attributes his educational philosophy to his own schooling experience in a progressive, social-constructivist school during his early years in Honolulu, Hawaii. He taught in Honolulu, Hawaii, and Dakar, Senegal, for over a decade before moving into school leadership. Kapono has led schools in the United States and Egypt, where he put into practice the philosophy of "students making the world a better place," shifting school culture to impact-based education practice. His strong belief in education being an act of social justice drives his work.Kapono has worked internationally in educational change organizations, leading the work of Deeper Learning and place and culture-based pedagogy, and he is currently the Executive Director for What School Could Be. In these roles, he has trained teachers in over 100 schools and school districts over four continents, impacting hundreds of thousands of students. In addition, Kapono spent 15 years as National Faculty for the National Association of Independent Schools in Diversity, Equity, Inclusion, and Justice, facilitating national and international learning experiences. As a curriculum writer, he has authored multiple curricula for federal and non-profit programs. His work has significantly contributed to the organizations What School Could Be, The Buck Institute, EdLeader21, The Pacific American Foundation, and many others.Kapono holds a Ph.D. in International Education Leadership from Northcentral University, a Masters degree in Social Change and Development from the University of Newcastle, and a Bachelors of Language and Culture from the Evergreen State College. He currently lives between Hawaii, Cairo, Egypt, and Dakar Senegal.Enjoying the show? Leave us a rating and review and help more people find us!bit.ly/RebelEducatorApplePodcastsWe'd love it if you could take a few minutes to fill out this survey to let us know how we can bring you the best possible content: forms.gle/JcKHf9DHTZnYUmQr6 Interested in being on the Rebel Educator podcast? Fill out this form and we'll reach out to you if we think you'd be a great fit for an upcoming episode. https://forms.gle/CZJXLQDdevPh22ZN7Want to learn more about opening your own UP Academy? Check out the Rebel Educator Accelerator:www.rebeleducator.com/courses/the-acceleratorMORE ABOUT THE REBEL EDUCATOR PODCAST:In each episode of the Rebel Educator podcast, I deconstruct world-class educators, students, and thought leaders in education to extract the tactics, tools, and routines that you can use as teachers and parents. Join me as we discuss how to shift the classroom, the learning environment, the mindset, and the pedagogy, to resist tradition, reignite wonder, and re-imagine the future of education.This podcast is dedicated to all of the educators who work thankless hours to make our next generation the best it can be.  It was designed to begin conversations on how we can redesign education for the future of work and the success of our students.  It is meant for teachers, students, administrators, homeschoolers and anyone who interacts with and teaches youth. Ready to Turn Your Expertise into a Business?Don't miss Educator 2 Entrepreneur (E2E), a groundbreaking course by my friend, Anthony Kim -  3x successful founder, bestselling author, and education thought leader.E2E is specifically designed for educators ready to make the leap into entrepreneurship, even without startup capital or traditional business experience. Through 20 action-packed lessons across 5 modules, you'll master Anthony's proven framework to build a thriving and sustainable education business.Learn more here:  https://www.educator2entrepreneur.org/a/2148024700/NbhcSHYvWe're thrilled to be sponsored by IXL. IXL's comprehensive teaching and learning platform for math, language arts, science, and social studies is accelerating achievement in 95 of the top 100 U.S. school districts. Loved by teachers and backed by independent research from Johns Hopkins University, IXL can help you do the following and more:Simplify and streamline technologySave teachers' timeReliably meet Tier 1 standardsImprove student performance on state assessments

Blair shares his unique journey into the tech industry, the evolution of technology from hardware to AI, and offers valuable advice for entrepreneurs. He also discusses the innovative work being done at the Buck Institute in the field of longevity and how AI is transforming healthcare and personalized medicine. Follow Blair on LinkedIn The Buck Institute: https://www.buckinstitute.org/ Get on the AI Box Waitlist: ⁠⁠https://AIBox.ai/⁠⁠ Join my AI Hustle Community: https://www.skool.com/aihustle/about 00:00 Introduction to Blair LeCorte and His Journey 05:58 The Evolution of Technology: From Hardware to AI 11:58 Advice for Tech Entrepreneurs 16:02 The Buck Institute and Innovations in Longevity 21:54 The Shift from Illness Treatment to Prevention 28:06 Personalized Health: The Role of Data 41:44 Practical Steps for Longevity and Wellness AI Chat YouTube Channel: https://www.youtube.com/@JaedenSchafer My Podcast Course: https://podcaststudio.com/courses/ Get on the AI Box Waitlist: ⁠⁠https://AIBox.ai/⁠⁠ Join my AI Hustle Community: https://www.skool.com/aihustle/about

Trevor Muir, an inspiring keynote speaker who celebrated the power of storytelling in education and an avid Harry Potter fan, sits down with host Kevin Stoller and co-host Carla Cummins to dive into the real-world connections between education and the beloved book series. They explore the different teaching styles depicted in Harry Potter and the Sorcerer's Stone, the importance of building strong relationships with students, and how elements of the wizarding world can inform and inspire today's learning environments. At last year's LearningSCAPES conference, we had the pleasure of connecting with Trevor Muir, an inspiring keynote speaker who celebrated the power of storytelling in education. His keynote emphasized how authentic engagement empowers students, even through challenging times, by integrating real-world projects. From screening interviews with WWII veterans to creating helpful guides for recent immigrants, his approach demonstrated the impact of learning beyond the classroom. Now, we just need to provide agile spaces to support this type of transformative learning. Tune in to this magical conversation as we explore how the world of Harry Potter can inspire real-world educational practices.   Takeaways: Everyone has their own superpowers It's important to be intentional when sorting students Caring for your students is one of the most impactful things you can do     About Trevor Muir: Trevor is a teacher, author, creator, and co-founder of the New Teacher Academy. His books The Epic Classroom, The Collaborative Classroom, and New Teacher Mindset have helped teachers worldwide to create purposeful and dynamic learning experiences. Trevor has taught in middle, high school, and college classrooms, as well as pre-service teachers at Grand Valley State University. He was a national faculty member for the Buck Institute for Education and his work has been featured in the Huffington Post, Edutopia, EdWeek, and WeAreTeachers. Trevor's inspiring and informative videos have been viewed over 30 million times. At the heart of Trevor's work is the conviction that every student has the potential for greatness, and that every teacher can be equipped to unlock that potential.   Connect with Trevor Muir: Website: https://www.trevormuir.com/ Instagram: https://www.instagram.com/theepicclassroom Twitter: https://x.com/TrevorMuir Facebook: https://www.facebook.com/epicclassroom/ YouTube: https://www.youtube.com/c/TrevorMuir   Connect with co-host, Carla Cummins: LinkedIn: https://www.linkedin.com/in/carla-cummins-01449659/   Connect with host, Kevin Stoller: LinkedIn: https://www.linkedin.com/in/kevinstoller/     Episode 217 of the Better Learning Podcast Kevin Stoller is the host of the Better Learning Podcast and Co-Founder of Kay-Twelve, a national leader for educational furniture. Learn more about creating better learning environments at www.Kay-Twelve.com.     For more information on our partners: Association for Learning Environments (A4LE) - https://www.a4le.org/ Education Leaders' Organization - https://www.ed-leaders.org/ Second Class Foundation - https://secondclassfoundation.org/ EDmarket - https://www.edmarket.org/ Catapult @ Penn GSE - https://catapult.gse.upenn.edu/ Want to be a Guest Speaker? Request on our website

This week on H-Span, we are joined by Brenda Eap, VP of Communications & Partnerships at the Alliance for Longevity Initiatives.In this episode, we discuss Brenda's journey to becoming a biology of aging researcher at the Buck Institute, and what our plans are for A4LI.

Blair LaCorte is a dynamic business executive who after being raised by two entrepreneurs has taken a path less traveled, unless of course you were Forrest Gump! Blair has held CEO or “C” level strategy or operating roles in companies such PRG (largest live entertainment production company), XOJET/Vista (largest private aviation company), TPG (one of largest PE firms), Autodesk (largest CAD SW company), and Sun Microsystems / Oracle (largest workstation HW company). In addition, Blair has taken several companies from start up to IPO such as AEye Technologies (1.5b IPO in 2021) and VerticalNet (#1 IPO in 1999). Today, Blair is currently an Astronaut in training for Virgin Galactic where he expects to fly in 2026. Blair is the Vice Chairman of the Buck Institute, the world's leading research organization on longevity and aging as well as Co-Founder and Facilitator of a highly rated Mastermind group of 40 global CEO's. What you will learn The value of self-awareness in achieving personal and professional growth. How adaptability and resilience can lead to unexpected opportunities. Why meaningful relationships are essential for happiness and success. Insights on using AI and technology for health and personalized care. Lessons on balancing career risks, timing, and personal authenticity.

As part of the US HUPO sponsored "Philly Express" series highlighting speakers at the upcoming 2025 US HUPO meeting in Philadelphia, Ben and Ben sit down to talk with Dr. Tara Tracy, Buck Institute for Research on Aging.

BUFFALO, NY- December 19, 2024 – We are pleased to announce that Dr. Marco Demaria, a leading expert in aging and cellular senescence, will join Aging (Aging-US) as Editor-in-Chief, starting January 1, 2025. Dr. Demaria will work alongside an esteemed Editorial Board. Dr. Demaria has an impressive background in aging research. He earned his PhD in Molecular Medicine from the University of Torino, Italy. In 2010, he joined the laboratory of Aging Founding Editor, the late Dr. Judith Campisi, at the Buck Institute for Research on Aging. There he developed cellular and animal models for studying cellular aging, also known as cellular senescence, and its role in tissue repair, cancer, and aging. Currently, Dr. Demaria leads DemariaLab, whose mission is “to extend human healthspan by pioneering discoveries in molecular and cellular mechanisms that regulate the aging process.” His groundbreaking research has significantly advanced our understanding of cellular senescence and its role in aging and age-related diseases. Dr. Demaria aims to develop new therapeutic approaches to create more effective treatments that mitigate the diseases and extend the healthspan. His work specifically focuses on interfering with the mechanisms of cellular senescence using genetic, pharmacological, and nutraceutical strategies. “My research is focused on understanding the molecular basis of age-related dysfunctions and disorders, and to identify new molecular and cellular targets to improve health and longevity.” - Marco Demaria He is also a Full Professor at the European Research Institute for the Biology of Ageing (ERIBA), Director of the Mechanisms of Health, Ageing and Disease (MoHAD) at the University Medical Center Groningen (UMCG), President of the International Cell Senescence Association (ICSA), and Co-Founder of Cleara Biotech. Dr. Demaria also brings valuable editorial experience from his former positions as Editor-in-Chief of npj Aging and Editorial Board member of Aging Cell. All the above, combined with Dr. Demaria's academic contributions, commitment, and expertise, align perfectly with Aging's mission to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population. For more information about Marco Demaria, PhD, please visit www.demarialab.com and follow him on X (Twitter) @marc_dema or on Bluesky @marcdema.bsky.social. About Aging-US Please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

What if aging wasn't inevitable, but something you could slow—or even reverse? In this episode of “The Dr. Hyman Show,” Dr. Eric Verdin, the president of the Buck Institute for Research on Aging, and I dive deep into the science of longevity. Discover how lifestyle choices, mitochondrial health, and cutting-edge research are transforming our understanding of aging. From fasting and nutrient sensing to emerging therapies like CD38 inhibitors, this episode reveals actionable insights to help you live a longer, healthier life. In this episode, we discuss: The Role of Mitochondria in Aging The Critical Role of NAD Levels and Aging Lifestyle Interventions for Longevity Gene Therapy The Importance of CD38 and Enzyme Inhibition View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman's Weekly Longevity Journal This episode is brought to you by Rupa Health, BIOptimizers, LMNT, and Fatty 15. Streamline your lab orders with Rupa Health. Access more than 3,500 specialty lab tests and register for a FREE live demo at RupaHealth.com. Don't let stress take over your holidays. Try Magnesium Breakthrough from BiOptimizers. Head to Bioptimizers.com/Hyman and use code HYMAN10 to save 10%. LMNT is giving listeners a FREE eight-count sample pack of their vital electrolyte drink mix with any purchase. Just visit DrinkLMNT.com/Hyman today. Fatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 15% off a 90-day starter kit subscription. Just visit Fatty15.com and use code DRHYMAN10 to get started. Learn more about your ad choices. Visit megaphone.fm/adchoices

There is a lot of talk about living to the age of 100 or more, but not as much about the threat of age-related disease. Dr. Gordon Lithgow of the Buck Institute, the world's first biomedical research institution devoted to research on aging, believes we can stay healthy as we live longer. It all starts with biology...and worms. Brought to you by NEXTVillageSF.orgNEXT Village SF is a neighborhood nonprofit providing services and support that empowers members to live independently.

In this episode of the Mind Gut Conversation podcast, I speak with Dr. Eric Verdin, one of the world's experts on healthy aging and longevity. Dr. Verdin is president and CEO of the Buck Institute for Research of Aging, the world's only research institution singularly focused on the biology of aging. During this episode, we talk about a number of fascinating topics, including: 1) Besides lifestyle modifications, what are the most promising strategies to increase the health span in humans? 2) What is the reason for the progressive increase in centenarians in different parts of the world? 3) What role do genes play in longevity? Enjoying our podcast? Please leave us a review and any feedback to improve our show!

In this episode of the Mind Gut Conversation podcast, I speak with Dr. Eric Verdin, one of the world's experts on healthy aging and longevity. Dr. Verdin is president and CEO of the Buck Institute for Research of Aging, the world's only research institution singularly focused on the biology of aging. During this episode, we talk about a number of fascinating topics, including: 1) Besides lifestyle modifications, what are the most promising strategies to increase the health span in humans? 2) What is the reason for the progressive increase in centenarians in different parts of the world? 3) What role do genes play in longevity? Enjoying our podcast? Please leave us a review and any feedback to improve our show!

Dr. David Furman is a key researcher at the Buck Institute for Research on Aging, where he focuses on understanding the underlying mechanisms of aging and chronic diseases, particularly through the lens of the immune system. His research centers around "inflammaging," the concept that low-grade, chronic inflammation contributes to the aging process and the development of age-related diseases like cardiovascular disease, neurodegenerative disorders, and metabolic syndromes. At the Buck Institute, Dr. Furman leads efforts to unravel how immune dysfunction plays a pivotal role in accelerating biological aging. His work integrates systems biology approaches, including advanced computational and bioinformatic tools, to analyze large datasets related to human immunity and inflammation. By understanding how these systems change over time, Dr. Furman aims to identify biomarkers of aging and develop therapeutic strategies to target inflammaging. In addition to his role at the Buck Institute, Dr. Furman is involved in the 1000 Immunomes Project, a large-scale initiative to map the immune systems of individuals across different age groups. This project has contributed significantly to the growing understanding of how the immune system deteriorates with age and how this process may be modifiable through intervention. Dr. Furman's work is influential in the longevity and biotech spaces, and he continues to be a thought leader in the development of anti-inflammatory therapies to extend healthspan and potentially delay the onset of age-related diseases. Timestamps 00:00 Introduction to Inflammation and Longevity 03:06 Understanding Inflammation and Aging 05:52 The Role of Environment in Inflammation 09:14 Ancestral Lifestyle Experiment 12:04 The Importance of Movement and Daily Activity 14:54 Nutrition and Its Impact on Health 18:14 The Future of Aging Research and AI 21:02 The Threat of Microplastics 23:53 Conclusion and Future Directions

Welcome back to Egg Meets Sperm! I'm Dr. Aumatma, and this is the best podcast to get all the vital information you need to support your fertility journey holistically for you and your partner—because fertility takes two.Today, we're joined by Dr. Joseph Antoun, CEO of L-Nutra, the company behind the groundbreaking ProLon Fasting Mimicking Diet. Dr. Antoun's passion is enhancing human longevity, and he's here to share how fasting can impact fertility and support reproductive health.In this fascinating conversation, we dive into:✨ Topics Covered:The science behind different types of fastingHow the Fasting Mimicking Diet promotes cellular rejuvenationThe connection between biological aging and fertilityClinical research on ProLon and its benefits for metabolic healthTips for safely incorporating fasting into your fertility journeyDr. Antoun also shares incredible insights from his impressive background in health policy and aging research, including how fasting can reverse biological age and improve overall vitality.Dr. Joseph Antoun's passion is to enhance Human Longevity. He is the CEO and Chairman of the Board of L-Nutra Inc., a unique Nutrition technology company leading the Longevity and Food as Medicine markets.Before taking on these roles, Dr. Antoun was the CEO of Health Systems Reform, a boutique consultancy aimed at elevating public health through reforming health systems, strengthening healthcare management and improving healthcare delivery; the Co-Director of the Center for Health Policy at the University of Chicago; an adjunct Professor of Health Policy at the Buck Institute for Research on Aging; and a fellow at the Department of Social Policy at the London School of Economics and Political Science. Dr. Antoun founded and served as the Co-Editor in Chief of the Journal of Health Systems and Reform. He served as the Chairman of the Board at the Global Healthspan Policy Institute (GHPI), as member of Forbes Business Development and as head of Business Development for Emerging Markets at Eli Lilly & Company.Dr. Antoun has dedicated his professional experience to launching two novel markets: the first is the Longevity Market whereby he launched the first tested and patented healthy aging product called ProLon. The second is the Food as Medicine market whereby he launched Nutrition for Longevity which is now amongst the first food ever to be reimbursed by CMS and insurances.Dr. Antoun completed his Health Policy studies at Harvard University, Public Health at Johns Hopkins University, Medicine and Biological Sciences at Saint Joseph University, and his PhD studies in Mediterranean & Middle Eastern Studies at King's College. He is married to the loveliest Carine, has three amazing boys and stays healthy by consuming ProLon and walking daily for hours while on his phone.Learn more about Dr. Antoun and ProLon:L-Nutra: https://l-nutra.comProLon Fasting Mimicking Diet: https://prolonfast.comLet's chat! I want to hear from you! Send me a voice memo with:- what you loved- what you want to see improve- any guests you want me to bring on- AND any questions you want me to cover on the podcast!Did you know you can join my private community to support you in getting Fertile As...

In this weeks episode of "Pushing the Limits" , Dr. David Furman, Director of the 1000 immunomes project, the world's largest longitudinal population-based study of immunology and aging at Stanford University and Associate Professor at the Buck Institute for Aging, Founder of Edifice Health and Cosmica Biosciences, discusses his extensive research in immunology, particularly focusing on the 1000 Immunomes Project, which aims to understand the immune system's role in aging.  He emphasizes the importance of studying human biology over traditional animal models and introduces the concept of the Inflammation Age Clock as a new biomarker for aging.  The discussion also covers the implications of systemic chronic inflammation in aging, the role of nutrition, and the potential for interventions to improve health span. Additionally, Dr. Furman shares insights into his work with NASA on accelerated aging in astronauts, highlighting the broader applications of his research in combating age-related diseases.   Takeaways:    Dr. Furman aims to have a massive impact on human health. The immune system plays a crucial role in aging. Human studies provide better insights than animal models. The Inflammation Age Clock is a new biomarker for aging. Chronic inflammation is a key factor in age-related diseases. Nutrition significantly affects inflammation and aging. Reliable biomarkers are needed for effective aging interventions. NASA's research on astronauts reveals accelerated aging in space. The convergence of technologies is revolutionizing health research. Future research will focus on protecting astronauts and advancing aging studies. Titles: System Chronic Inflammation: The Hidden Driver of Aging Nutrition and Inflammation: Key Factors in Health span   About the 1000 immunomes Project: The Stanford 1000 Immunomes Project (KIP) is a collaborative ongoing study at Stanford University that aims to define the biological basis of aging and disease using state-of-the-art 'omics' platforms and advanced artificial intelligence (AI) methods. The main focus of 1KIP is to establish biomarkers for healthy versus sub-functional immune systems. They do this by identifying the interactions between genetic and environmental factors, which contribute to the observed heterogeneity of biological responses in human beings.  To this end, 1000 individuals of different age groups (9-96 years old) were recruited between 2007-2017. Their blood samples were screened using multiple state-of-the-art technologies at a single facility, the Human Immune Monitoring Center (HIMC) to measure circulating proteins, cell types, cellular functions, whole-genome blood gene expression and subjects' haplotypes using deep sequencing technologies. The 1KIP dataset has enabled us for the first time to identify reliable biomarkers of aging and disease in a longitudinal population-based study of immunology and aging. 1KIP provides reference values for thousands of immune variables and identifies clusters of individuals sharing similar health versus disease immune profiles. BIO Dr. David Furman is an academic entrepreneur deeply committed to addressing intricate challenges within human biology, systems medicine, translational immunology, preventative healthcare, aging, and precision longevity. Holding positions as the Director of the Stanford 1000 Immunomes Project at the Stanford School of Medicine and as an Associate Professor and Director of the Bioinformatics and Data Science Core at the Buck Institute for Research on Aging, Dr. Furman leads research endeavors that leverage multi-scale biology ('omics') platforms and advanced AI/ML methodologies. He identifies biomarkers and integrative biological clocks essential for monitoring individual health statuses. Groundbreaking technologies originating from the Furman lab now facilitate the application of descriptive and mechanistic biomarkers to detect and combat accelerated aging and disease progression. With over 15 years of specialization in inflammation's role in aging mechanisms, Dr. Furman's expertise includes various domains, including neuroscience, cardiovascular health, metabolic diseases, and immune system function. Notably, in 2022, NASA's Human Research Program sought Dr. Furman's collaboration, leading to partnerships with SpaceX and Cornell University. Dr. Furman's entrepreneurial initiatives include the founding of the Inflammaging Institute, aimed at democratizing biological aging diagnosis, and the establishment of Stanford spin-off Edifice Health Inc., and Buck Institute spin-off Cosmica Biosciences Inc., both focused on innovative approaches to combat aging-related ailments and precision longevity interventions. Dr. Furman has published over 50 scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others, and is the inventor of over 25 patents.     Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with:  Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals  Nutristat Omega 3 to 6 status and more  Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the  challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa    Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission.  Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to  Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to  https://www.buymeacoffee.com/LisaT to donate $3   Lisa's Anti-Aging and Longevity Supplements  Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world.  This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life.   Subscribe to our popular Youtube channel  with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube   Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge"  Check them all out at  https://shop.lisatamati.com/collections/books   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here:    Use code "tamati" at checkout to get a 10% discount on any of their devices.   Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38   Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off     Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts.  To pushing the limits, Lisa and team

On this episode of Longevity by Design, Ashley Reaver, MS, RD, CSSD, and Dr. Gil Blander, delve into the intricate world of the immune system and its impact on aging with Dr. David Furman, Associate Professor at the Buck Institute for Research on Aging. David discusses his groundbreaking research on inflammaging— uncovering how chronic, low-grade inflammation can accelerate the aging process. Discover how David's team developed a new inflammatory age test, soon to be available from his company Edifice Health, that uses five key proteins to assess an individual's inflammatory state and predict future health risks. We also explore the surprising link between space travel and accelerated aging, examining the impact of microgravity on the body. Tune in to learn practical tips on combating inflammation and promoting longevity through lifestyle choices and a deeper understanding of your own personal health data.Episode highlights:Introduction: 00:00:00Why have you decided to be a scientist and not a painter: 00:04:001000 Immunomes: 00:06:00What is the immune system: 00:16:00Biomarkers related to the immune system: 00:18:00The development of frailty during the aging process: 00:21:00what inflammation is: 00:27:00Lifestlye dependent chronic stress: 00:31:00Inflammation-related biological clock: 00:34:00Epigenetic age: 00:38:00Centenarians and inflammatory markers: 00:48:00Space flight and inflammation: 00:51:00Astronauts aging: 00:55:00Microgravity as a stressor: 00:59:00Future of David's work: 01:04:00Summary: 01:06:00Not All Biological Age Clocks Are Created EqualWhile various biological age clocks exist, including epigenetic and glycan clocks, David's research highlights the benefits of protein-based clocks like his inflammatory age test. Unlike other clocks that closely correlate with chronological age, inflammatory age reveals more about an individual's biological state and potential health risks, offering valuable insights beyond simply reflecting the passage of time. Additionally, understanding how specific proteins link to inflammation allows for actionable lifestyle and dietary changes to positively impact those markers and potentially slow down the aging process. Lifestyle Choices Directly Impact Our Inflammatory LevelsMany modern lifestyle factors, often a far cry from our evolutionary past, contribute to chronic inflammation. These include exposure to environmental toxins like plastics and pesticides, poor sleep quality, disruptions to our circadian rhythm, social isolation, and chronic stress. By minimizing these exposome factors and adopting healthier habits—such as consuming whole foods, prioritizing sleep hygiene, and managing stress—we can potentially lower inflammation and support healthier aging. Space Travel Offers a Unique Perspective on Accelerated AgingAstronauts, despite being otherwise healthy individuals, experience accelerated aging due to the stressors of space travel, particularly the effects of microgravity. This provides valuable data on aging mechanisms that can be applied to Earth-bound research. By studying the physiological changes astronauts undergo, scientists can gain a deeper understanding of aging processes and potentially develop interventions to mitigate age-related decline for everyone. For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast 

Subscribe to our channel: https://www.youtube.com/@optispan Check out Productive Health: https://productivehealth.org/ Check out the Garrison Lab: https://garrisonlab.com/ We had a great time hosting Dr. Jennifer Garrison from the Buck Institute for Research on Aging to talk about her areas of expertise: reproductive aging and neuropeptide signaling. Jennifer and Matt go over the fascinating and chronically under-researched science of menopause, misconceptions about hormone replacement therapy, and the importance of considering the endocrine function of the ovaries alongside their role in reproduction. They also chat about evolutionary questions around menopause, changes they would like to see in medical school curricula, and more. In addition to her research lab at the Buck, Jennifer serves as co-founder and director of Productive Health, formerly the Global Consortium for Reproductive Longevity & Equality, which is the global arm of the Buck Center for Healthy Aging in Women. She holds appointments at the University of California, San Francisco and the University of Southern California. She is also a Founding Director of the Marine Biological Laboratory (MBL) Woods Hole Biology of Aging (BOA) Advanced Training Course. She has received numerous awards, including a National Institutes of Health Maximizing Investigators' Research Award (MIRA) for Established Investigators, a Glenn Medical Foundation Award for Research in Biological Mechanisms of Aging, an American Federation of Aging Research Junior Faculty Award, and a National Academy of Medicine Healthy Longevity Catalyst Award. Jennifer conducted postdoctoral research at Rockefeller University and received a PhD and a B.A. from the University of California, San Francisco and the University of California, Berkeley respectively. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan Instagram: https://www.instagram.com/optispanpodcast/ Facebook: https://www.facebook.com/profile.php?id=61563453482706 TikTok: https://www.tiktok.com/@optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Special THANKS to the episode sponsor Magic Mind! Limited offer: Get up to 48% off your first subscription or 20% off one-time purchases with code   CLAUDIAG20  at checkout.   You can claim it at: https://magicmind.com/claudiag   ------------- EPISODE SUMMARY Join scientist and mindset & high-performance coach Claudia Garbutt and longevity expert Dr. Joseph Antoun, the CEO of L-Nutra as they discuss science-backed strategies for living longer, healthier lives.   In this episode, we talk about: - Fasting & the Fasting Mimicking Diet - Why Intermittent Fasting is not Enough - Best Science-Backed Tips for Promoting Longevity & Healthspan   EPISODE NOTES Dr. Joseph Antoun is a visionary leader and renowned expert in the field of longevity, dedicated to enhancing human healthspan through cutting-edge nutrition technology. As the CEO and Chairman of the Board at L-Nutra for over 7 years, Dr. Antoun is at the forefront of the booming longevity industry. Prolon has sold more than 3M products, has more than 1M customers globally, and backed by $100M in funding and 132+ patents.   Dr. Antoun served as the Chairman of the Board at the Global Healthspan Policy Institute (GHPI) and as a member of Forbes Business Development Council.   Before taking on these roles, Dr. Antoun was the CEO of Health Systems Reform, a boutique consultancy aimed at elevating public health through reforming health systems, strengthening healthcare management and improving healthcare delivery; the Co-Director of the Center for Health Policy at the University of Chicago; an adjunct Professor of Health Policy at the Buck Institute for Research on Aging; and a fellow at the Department of Social Policy at the London School of Economics and Political Science. Dr. Antoun founded and served as the Co-Editor in Chief of the Journal of Health Systems and Reform.   Dr. Antoun has dedicated his professional experience to reforming health systems towards preventive care, to create a market for healthy aging by launching the first aging and longevity product called ProLon, and to bringing back fasting as a longevity practice to humanity. In 2016, Dr. Antoun launched the Fasting Market, which by 2018, became the #1 nutrition regimen in the US, and continues to grow in popularity. In 2018, the Fasting Mimicking Diet was granted a patent on 'promoting longevity and healthspan'.   Dr. Antoun completed his Health Policy studies at Harvard University, Public Health at Johns Hopkins University, Medicine and Biological Sciences at Saint Joseph University, and his PhD studies in Mediterranean & Middle Eastern Studies at King's College.   Links: www.prolonlife.com   https://l-nutra.com/   https://www.instagram.com/prolon/?hl=en    https://www.facebook.com/prolonfmd/   https://www.linkedin.com/in/drjosephantoun/     ------------ Click this link to listen on your favorite podcast player and if you enjoy the show, please leave a rating & review: https://linktr.ee/wiredforsuccess   ------------------   Music credit: Vittoro by Blue Dot Sessions (www.sessions.blue)   -----------------   Disclaimer: Podcast Episodes might contain sponsored content.

In this episode of Longevity by Design, hosts Ashley Reaver and Dr. Gil Blander welcome Dr. Julie Andersen, a distinguished neuroscientist at the Buck Institute for Research on Aging, who discusses her groundbreaking work on neurodegenerative diseases, focusing on Parkinson's and Alzheimer's. She explains how the field of geroscience is transforming our understanding of aging, revealing that common underlying processes in various diseases could lead to universal therapeutic approaches.Dr. Andersen dives into the gut-brain connection, highlighting how gut health significantly impacts brain aging and the progression of neurodegenerative diseases. She also emphasizes the importance of cellular senescence, a process where aging cells stop dividing, contributing to diseases like Alzheimer's. Her research explores innovative ways to slow or prevent these processes, paving the way for new treatments.The episode concludes with Dr. Andersen advocating for lifestyle interventions, particularly exercise, as powerful tools in preventing neurodegenerative diseases. She underscores the potential of personalized medicine in tailoring treatments to individual aging patterns, offering hope for more effective and targeted therapies.Episode highlights:Introduction: 00:00:00Dementia as a side effect of aging: 00:06:00Dementia prevalence in the population: 00:10:00The environment and Alzheimer's disease: 00:15:00Biological sex effect on Dementia 00:17:00Ethnicity effect on Dementia  00:18:00What to expect when you are diagnosed with Dementia 00:19:00Biomarkers for Dementia 00:26:00The connection between the hallmarks of aging and Dementia: 00:30:00 Exercise and Dementia: 00:34:00disruption of REM sleep as an early sign of Parkinson's: 00:37:00What is the current treatment for Parkinson's: 00:38:00Cellular senescence and neurodegenerative diseases: 00:42:00Beta amyloid plaques and Alzheimer's disease: 00:50:00Autophagy and dementia: 01:00:00What would you recommend to a person who like to live better and longer: 01:08:00

Host Pete Moore is joined by an industry pioneer and long-time friend Jill Kinney, currently the Founder/Chairman of Active Wellness. They deep dive into the ever-evolving landscape of fitness for the senior population, focusing on Jill's innovative work with Active Wellness. She shares her insights on redefining fitness centers, especially within healthcare systems and senior living communities, through the creation of Activate—a high-touch, personalized wellness program which are transforming traditional spaces into profitable, consumer-facing wellness hubs.  Drawing from a rich background in developing, owning, and operating fitness clubs, Jill has successfully melded her expertise to create distinct, consumer-focused models within the industry.  Kinney states, "I don't think the health care systems or hospitals per se, really understand marketing. Most of the folks that we've dealt with felt like their medical fitness center was somehow or another going to be so unique that it would have no competition . . . and there's there's nothing further from the truth . . . what we've done is taken our branding, marketing, and sales skills and turned these businesses around, so they're profitable. They're generating 18 to 25% EBITDA returns." Key themes discussed Challenges of managing hospital real estate assets. Personalized wellness program with brain training, recovery, and E-Gym. Excitement for real estate investment opportunities and models. Opening up facility to public feedback. A few key takeaways:  1. Active Wellness is a fitness and wellness management company that provides a unique twist through two distinct models: -Active Wellness Centers: These are similar to medical fitness centers but with a profitability and business focus, making them more consumer-facing and competitive. -Activate Program: A turnkey, approximately $2,000,000 solution with a small footprint (5,000-10,000 square feet), integrating personalized wellness and fitness programs featuring high-tech and data-driven approaches. 2. Hospitals and healthcare systems often underestimate the importance of sales and marketing, especially when it comes to running fitness centers. Active Wellness steps in to turn these facilities into profitable, consumer-friendly wellness centers that attract members and operate with commercial efficiency. 3. The Activate program includes a variety of personalized services such as personal health coaching, registered dietitians, and specialized equipment like eGym for tailored fitness plans. Emphasis is placed on a holistic approach encompassing fitness, recovery, and even brain training. 4. Activate centers generate significant financial returns (28%-35% ROI on invested capital starting from year 2) and transform previously cost-center amenities into profitable entities. 5. Although initially targeted at seniors and independent living communities, the program's appeal is broadening to a younger demographic. Active Wellness plans to scale up, aiming to have around 20 Activate locations in the near future, with a longer-term goal of expanding to 50-100 locations. Click here to download transcript.  Resources:  Jill Kinney: https://www.linkedin.com/in/jillkinney/ Active Wellness: https://activewellness.com/  Buck Institute: https://www.buckinstitute.org/  E-Gym: https://egym.com/us  Prospect Wizard: http://www.theprospectwizard.com Promotion Vault: http://www.promotionvault.com HigherDose: http://www.higherdose.com  Connect With Us:  Instagram: https://www.instagram.com/thehaloadvisors/?hl=en  Facebook: https://www.facebook.com/Integritysquare  YouTube: https://www.youtube.com/@halotalks  LinkedIn: https://www.linkedin.com/company/integrity-square/  Website: https://www.halotalks.com

In this episode of Money Tales, our guest is Maher Kaddoura. At just 13 years old, Maher embarked on a solo journey that would forever change his perspective on life and money. Traveling alone, across international borders, taking buses and hitchhiking, Maher explored Turkey and Bulgaria. As the son of a refugee, Maher was no stranger to the survival instinct. From a young age, it was ingrained in him that he had to earn money for anything he wanted. Maher discovered that money earned through his own hard work and effort tasted much sweeter. He also learned that he had control over his choices. Maher believed that if he improved his decision-making process when it came to money that would increase the chances of financial success and create a better future for himself. Maher Kaddoura stands out as role model of innovation and social entrepreneurship. As a former managing partner at Accenture-Middle East and a seasoned entrepreneur, Maher has founded several firms that are leaders in their fields, from strategy consulting to system integration. His investments and board roles span a variety of sectors, illustrating his versatile business acumen and dedication to fostering growth in the knowledge economy and beyond. Maher serves on the advisory boards of prestigious institutions such as the National University of Singapore (NUS), University of Chicago, and the Buck Institute, where his strategic insights significantly enhance their initiatives in research and education. His global perspective enriches these institutions, bridging the gap between academic theory and real-world application. Maher recently authored "The Art of Leapfrogging," a book that encapsulates his innovative approach to bypassing traditional steps in problem-solving and development to achieve accelerated results. This publication has positioned him as a thought leader, further extending his influence in the realms of social change and entrepreneurship. Maher's commitment to societal improvement is evident through his founding of Al-Jude NGO in 1999, which spearheads high-impact social programs. His "Falafel Theory" of maximizing resources for widespread benefit drives his initiatives, such as the Hikmat Road Safety program and the MeshMosta7eel TV show, which challenges participants to tackle national issues creatively. An avid adventurer, Maher's travels to over 100 countries enrich his understanding and appreciation of global cultures. His experiences from the Arctic to the mountains of South America are not just adventures but also a source of inspiration and learning that he shares through his engaging storytelling and street photography.

In this episode of Longevity by Design, hosts Ashley Reaver and Dr. Gil Blander welcome Dr. Brianna Stubbs, an expert in exogenous ketone metabolism. Dr. Stubbs shares her journey from being a competitive rower to becoming a scientist. She dives into her research on ketone biology and its implications for health and aging.Dr. Stubbs discusses the science behind ketones, explaining how they serve as an alternative fuel for the brain and body, particularly during periods of low carbohydrate intake. She highlights the potential benefits of ketones for cognitive function and heart health, noting their ability to act as signaling metabolites that influence oxidative stress and inflammation.The conversation also explores the practical applications of ketone supplements for athletes and the general public. Dr. Stubbs emphasizes the importance of personalized approaches to diet and supplementation, considering individual goals and health conditions. She provides insights into her ongoing research at the Buck Institute, aiming to translate scientific discoveries into practical tools for healthy aging.

Originally Released October 24, 2023The ovaries play a key role in overall health, not just reproduction. More scientific findings are revealing that the ovaries even influence mood, behavior, and longevity. In this episode, Dr. Jennifer Garrison from the Buck Institute for Research on Aging explains the intricate relationship between the brain and reproductive organs. She covers topics including the science of aging, the “hypothalamus pituitary gonadal axis”, menopause and health, hormone replacement therapy, and the importance of understanding ovarian function.Dr. Jennifer Garrison is a PhD scientist and the head of a research lab at the Buck Institute, an independent institute dedicated to studying aging as a risk factor for diseases. Listen as Dr. Garrison explores how age is the primary risk factor for most chronic diseases including cardiovascular disease, cancer, and neurodegenerative diseases. Discussed in this episode:How the brain controls female physiology, including reproductive functionEarly menopause and POI/POF Menopause and how it relates to overall health The fascinating story women's ovaries can tell us about aging Understanding hormones as messengers in the bodyThe impact of diet and exercise on aging and fertility How understanding the aging process can help target and treat age-related diseasesHormone replacement therapy for hormonal imbalances during agingPhysical and emotional symptoms associated with periods, motherhood, and menopause"If we can understand the mechanisms that underlie aging— what's causing it, what's driving it— then we can use that knowledge to target age-related diseases." — Dr. Jennifer GarrisonRelated to this episode:Related episodes: Primary Ovarian Insufficiency (POI) and Menopause | Dr. Mandy LeonhardtRelated episode: Women's Health and the Ovulation Cycle | Dr. Jerilynn PriorDr. Garrison's Lab at Buck Institute: www.buckinstitute.org/lab/garrison-lab Dr. Jennifer Garrison on Twitter and LinkedIn Find Global Consortium for Reproductive Longevity and Equality (GCRLE) on Twitter, Instagram, and LinkedInResources and episodes on Breaking Taboos Recommended Books on Hormones and Menstrual Health Resources and episodes on Perimenopause & Menopause and sign up for the

275 Delaying Menopause - Understanding the Ovary Dr. Jennifer Garrison, a researcher and assistant professor at the Buck Institute for Research on Aging, discusses her work on women's health and aging. She explains that her goal is to understand the underlying mechanisms of aging and develop interventions that promote women's health. Dr. Garrison focuses on the role of the hypothalamus, a part of the brain that controls various homeostatic systems in the body, including reproductive function. She emphasizes the importance of studying bioactive peptides, which act as chemical signals between the brain and other tissues. Menopause is defined as the cessation of menstruation for 12 months, but it also coincides with changes in ovarian function and the production of various chemical signals. Dr. Garrison highlights the need for further research to understand ovarian function and develop interventions to extend ovarian health. The conversation explores the work of the Center for Reproductive Longevity and Equality and the importance of maintaining ovarian function for healthy aging in women. The center funds grants to scientists and clinicians studying ovarian aging and has seen significant progress in the field. The discussion also touches on the use of frozen ovarian tissue for preserving fertility in cancer patients and the role of peptides in reproductive function. The conversation emphasizes the need to reframe the narrative around women's health and highlights the inequality in health span between men and women. Takeaways Understanding the underlying mechanisms of aging can lead to interventions that promote women's health. The hypothalamus plays a crucial role in regulating various homeostatic systems in the body, including reproductive function. Bioactive peptides act as chemical signals between the brain and other tissues, influencing various physiological processes. Menopause is defined as the cessation of menstruation for 12 months, but it also involves changes in ovarian function and the production of chemical signals. Further research is needed to understand ovarian function and develop interventions to extend ovarian health. The Center for Reproductive Longevity and Equality funds grants to study ovarian aging and has seen significant progress in the field. Frozen ovarian tissue can be used to preserve fertility in cancer patients. Peptides play a crucial role in reproductive function, but caution should be exercised when using peptide therapies. The narrative about women's health needs to be reframed to focus on maintaining ovarian function for healthy aging. Women live longer than men on average but spend a longer portion of their lives in poor health, highlighting an inequality in health span. https://www.buckinstitute.org/lab/garrison-lab/ https://www.linkedin.com/in/drjennifergarrison/ https://gcrle.org/ Special thanks to our sponsor, SOLV Wellness! To learn more about Ellura by Solv Wellness, visit ellura.com for 30% off your first purchase automatically applied at checkout. For an additional $5 off, use coupon code DRKELLY5. Preorder my book "You Are Not Broken: Stop "Should-ing" All Over You Sex Life" Listen to my Tedx Talk: Why we need adult sex ed Take my NEW Adult Sex Ed Master Class: https://www.kellycaspersonmd.com/adult-sex-ed Join my membership to get these episodes ASAP, a private facebook group to discuss and my private accountability group for your health, hormones and life support! www.kellycaspersonmd.com/membership

I got the opportunity to talk to Dr. Eric Verdin, CEO of Buck Institute and an accomplished entrepreneur. We also talked about health advice for longevity, the supplement industry, beef between Dr Charles. Brenner and Dr. David Sinclair, Bryan Johnson, and his passion for F1. --------------------------------Thanks to the sponsors:Audible: Use my link for a 30-day free trial: http://audibletrial.com/diamondgoat Newsly: https://newsly.me promo code to receive a 1-month free premium subscription: EARLYMORNING Libysn: https://libsyn.com promo code: DGDubby Energy: https://www.dubby.ggpromo code for 10% off: DIAMONDGOATOpus Clips:  https://www.opus.pro/?via=diamondgoatDiamondgoat ----------------------------------------------------------------------------------Listen on: Podcast website: https://anchor.fm/diamondgoatSpotify: https://open.spotify.com/show/0EuhA6WyuerHtVAqcFrFeORadioPublic: https://radiopublic.com/dg-earlymorning-show-WoML4rBreaker: https://www.breaker.audio/dg-early-morning-showPodcast YT channel clips: https://www.youtube.com/@dgearlymorningshowReason: https://reason.fm/podcast/dg-earlymorning-showApple Podcast: https://podcasts.apple.com/us/podcast/dg-early-morning-show/id1575451533 Amazon Music: https://music.amazon.com/podcasts/f050b86c-1dad-4bc3-b12f-6aa5fa62438c Tiktok: @dgearlymorningshow--------------------------------------Check out my other stuff:Instagram: @itzdiamondgoatTwitter: @lildiamondgoatMain YT channel: youtube.com/diamondgoatTiktok: @lildiamondgoatSoundcloud: @Lil DiamondgoatSpotify: @Lil DiamondgoatMerch store: https://diamondgoat.creator-spring.com

Subscribe to our channel: https://www.youtube.com/@optispan Related episodes: Reversing Biological Age: Have we finally found the answer?: https://youtu.be/ivP3QTyQ2d4 Matt recently attended the 52nd annual meeting of the American Aging Association in Madison, Wisconsin and met with several people doing fascinating work in the longevity field. One of these was Mark McCormick, an Assistant Professor at the University of New Mexico (UNM) Department of Biochemistry and Molecular Biology. At UNM, Mark runs a lab that investigates age-delaying drug targets, develops machine learning tools for studying aging, and identifies conserved aging mechanisms and pathways in model organisms and humans. Mark previously completed a postdoc with Brian Kennedy at the Buck Institute for Research on Aging, a PhD in Biochemistry and Molecular Biology with Cynthia Kenyon at the University of California, San Francisco, and a B.S. in Mechanical Engineering as well as a B.S. in Biology from the University of Texas at Austin. In this episode, Matt and Mark chat about aminoacyl-tRNA synthetases, a group of enzymes that play an essential role in protein synthesis. They discuss the promise and risks of tRNA synthetase inhibitors to treat diseases of aging and extend life- and healthspan (spoiler: don't take tRNA synthetase inhibitors yet). They also talk about why Mark's lab has held off on doing mouse experiments thus far, the challenges of proving causality in longevity experiments, interventions about which Mark is optimistic (or not), and more. Producers: Tara Mei, Nicholas Arapis Video Editor: Jacob Keliikoa DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices. More places to find us: Twitter: https://twitter.com/optispanpodcast Twitter: https://twitter.com/optispan Twitter: https://twitter.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan https://www.optispan.life/ Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it. On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

In this episode of Longevity by Design, hosts Ashley Reaver, MS, RD, CSSD, and Dr. Gil Blander sit down with Dr. Gordon Lithgow, a Professor and Vice President for Academic Affairs at the Buck Institute for Research on Aging. Dr. Lithgow's research focuses on understanding the mechanisms of aging and identifying genes and small molecules that can prolong lifespan. With a background in genetics from the University of Glasgow and extensive experience in biotechnology and aging research, Dr. Lithgow shares his journey from growing up in Scotland to leading a lab at the Buck Institute.Dr. Lithgow discusses the compelling nature of aging as a profound biological mystery, which drew him into the field. He highlights his lab's approach of following curiosity-driven research, often using the nematode worm C. elegans as a model organism due to its short lifespan and genetic similarities to humans. This unbiased method has led to significant discoveries, including genetic mutations and drug-like molecules that extend lifespan. The conversation also covers the concept of geroscience, which Dr. Lithgow helped coin, emphasizing the link between aging and chronic diseases. A major focus of Dr. Lithgow's work is studying protein homeostasis, which declines with age. Protein misfolding is implicated in many age-related diseases; that discovery moved the lab's focus from lifespan extension to efforts to understand drivers of healthspan and the causes of age-related chronic diseases, in particular Alzheimer's and Parkinson's. His work also includes the influence of environmental factors, such as mild heat stress, and dietary iron, vitamin D, and alpha-ketoglutarate (AKG) on aging. Dr. Lithgow's interdisciplinary collaborations aim to uncover new interventions to extend healthspan and longevity.Dr. Gordon Lithgow is also the host of Buck Institute for Research on Aging's podcast, "We're not getting any younger... yet" on which he speaks with some of the brightest scientific stars on the planet to search for—and actually find answers to—questions on aging. The podcast can be found at https://www.buckinstitute.org/podcasts/ and on podcast apps.Episode timestampsIntroduction: 00:00-02:42What led Dr. Gordon Lithgow to become a scientist and research the biology of aging?: 02:43-06:20Why are worms (C.-elegans) a good model for studying aging?: 06:21-07:55Why did Dr. Gordon Lithgow transition from research investigating ways for extending lifespan to extending healthspan?: 07:56-09:24What specific diseases is Dr. Gordon Lithgow researching?: 09:25-12:01What does protein shape mean for aging?: 12:02-13:12How does mild heat stress impact health and aging?: 13:13-16:35How does vitamin D and alpha-ketoglutarate impact aging, healthspan, and lifespan?: 16:36-25:26How does dietary iron impact aging, healthspan, and lifespan?: 25:27-29:57Are there more genes and proteins to be discovered that influence aging, or have they all been discovered?: 29:58-34:12What compound do you think has the most potential for extending healthspan and lifespan?: 34:13-35:54What is the impact of calorie restriction and exercise on healthspan and lifespan in humans?: 35:55-38:51What is the importance of clinical trials for aging research?: 38:52-42:09What are the future directions of Dr. Gordon Lithgow's research?: 42:10-43:38Dr. Gordon Lithgow's top tip for living better longer?: 43:39-48:50

The field of aging research is undergoing a revolution, and the Buck Institute is at the forefront of this transformative movement. In this captivating interview, Dr. Eric Verdin shares insights into the groundbreaking discoveries that are redefining our understanding of the aging process. From senescence and epigenetics to NAD metabolism and ketones, learn about the cutting-edge science that is paving the way for a future where age-related diseases are a thing of the past. Join us as we explore the exciting possibilities of the longevity revolution. Learn more about your ad choices. Visit megaphone.fm/adchoices

Are you curious about the future of education and how technology is shaping the way we learn? In this episode of the Better Learning Podcast, we embark on a fascinating journey into the world of project-based learning (PBL) and artificial intelligence (AI) with special guest David Ross. Join us as we delve into thought-provoking questions that unravel the potential of AI to revolutionize the classroom experience. Takeaways: David Ross has a background in sports writing and transitioned to become a teacher, with a focus on project-based learning (PBL). COVID-19 has challenged the notion that physical attendance in school is inevitable, leading to the exploration of alternative learning options. AI has the potential to empower teachers by saving time on administrative tasks and providing personalized learning experiences. Teacher training in AI and prompt engineering is crucial for effective implementation in the classroom. The current landscape of AI in education is still in the early stages, with a wide range of products and possibilities. AI can assist teachers in designing curriculum and writing projects for project-based learning (PBL). AI has the potential to upskill students and provide equitable educational opportunities, particularly for schools in economically disadvantaged areas or rural areas. The use of AI in various fields, such as chatbots, graphics, and video, can enhance the learning experience for students. Virtual reality experiences can level the playing field for students who don't have access to resources like museums or science centers. Anchoring projects in the local community can engage students and make learning more relevant and meaningful. David Ross is the former Senior Director of the Buck Institute for Education (now PBLWorks), where he wrote the PBL Starter Kit and created and directed the PBL World Conference. David later worked in Washington DC as the CEO of the Partnership for 21st Century Learning, where he coordinated the bipartisan 21st Century Learning Caucus in the United States House of Representatives. Follow on David Ross on Social Media: LinkedIn: https://www.linkedin.com/in/david-ross-b234b9ba/ Learn more about creating better learning environments at www.Kay-Twelve.com. Kevin Stoller is the host of the Better Learning Podcast and Co-Founder of Kay-Twelve, a national leader for educational furniture. Find out more about Kevin at https://www.linkedin.com/in/kevinstoller/. For more episodes of the Better Learning Podcast, visit https://www.betterlearningpodcast.com/   Episode 177 of the Better Learning Podcast Kevin Stoller is the host of the Better Learning Podcast and Co-Founder of Kay-Twelve, a national leader for educational furniture. Learn more about creating better learning environments at www.Kay-Twelve.com.   For more information on our partners: Association for Learning Environments (A4LE) - https://www.a4le.org/ Education Leaders' Organization - https://www.ed-leaders.org/ Second Class Foundation - https://secondclassfoundation.org/ EDmarket - https://www.edmarket.org/ Want to be a Guest Speaker? Request on our website!

The Buck Institute, a pioneer in aging research, is uncovering how ketones impact healthspan. Dr. Brianna Stubbs, a world-champion athlete turned researcher, shares insights on how these molecules are more than just an energy source. They act as potent signaling molecules, influencing key aging pathways. Learn about the institute's groundbreaking work and how ketone drinks might help us live better, longer. Learn more about your ad choices. Visit megaphone.fm/adchoices

Independent presidential candidate Robert F. Kennedy Jr. introduced his running mate at a rally in Oakland today. She is an unconventional choice, but not a surprising one, since Kennedy tipped his hand yesterday on this very program.  His vice presidential selection is Nicole Shanahan, a 38-year-old lawyer and tech entrepreneur from Oakland. She went to St. Mary's High School, then the University of Puget Sound, then got her law degree at Santa Clara. She made a lot of money founding a startup that used artificial intelligence to help manage patents, and married Google co-founder Sergey Brin. They had a daughter but Brin divorced Shanahan after just a few years. She leads a private foundation and has funded a lot of work at Stanford and the Buck Institute. So she has deep ties to Silicon Valley and philanthropy, access to many millions of dollars, and is the mother of a young girl on the autism spectrum. But she has no experience in politics or government and would be the youngest vice president in history, not to mention the first who is half Chinese. It was pretty clear today though that she's quite simpatico with Kennedy on many issues, most notably skepticism about vaccines and childhood disease, Patti and Bret. For more on this, KCBS Political Reporter Doug Sovern spoke with Anchors Bret Burkhart and Patti Reising.   

How might we create the conditions and spaces for learning to be wild? Or maybe we need to un-create them for wildness?I speak to Jennifer D. Klein and Jill Ackers-Clayton. Jennifer has a broad background in global education and global partnership development, student-centered curricular strategies, diversity and inclusivity work, authentic assessment, and experiential, inquiry-driven learning. She has facilitated workshops in English and Spanish on four continents, providing strategies for high-quality, globally connected project-based learning in all cultural and socioeconomic contexts, with an emphasis on amplifying student voice and shifting school culture to support such practices. Jennifer has worked with organizations such as the Buck Institute for Education, the Center for Global Education at the Asia Society, The Institute for International Education, Fulbright Japan, What School Could Be, the Centre for Global Education, TakingITGlobal, and the World Leadership School, to name a few. Jennifer's first book, The Global Education Guidebook: Humanizing K–12 Classrooms Worldwide Through Equitable Partnerships, was published in 2017, and her second book, The Landscape Model of Learning: Designing Student-Centered Experiences for Cognitive and Cultural Inclusion, was released in 2022.Jill is an influential educator with nearly three decades of experience across a broad spectrum of the educational sector. Her journey began as a mathematics teacher, evolving into a technology expert after achieving her CCNA & MCSE certifications in Denver, Colorado. Her skills in managing school networks and teaching K-8 technology led her to significant roles in educational leadership. Her publication, "Developing Natural Curiosity through Project-Based Learning: Five Strategies for the PreK-3 Classroom," highlights her dedication to innovative education. As the Director of Education at VS America, her current role focuses on transforming learning environments, a crucial aspect of impacting student lives daily. This role involves collaborating with architectural firms, interior designers, and furniture vendors globally to create adaptable, flexible, and dynamic learning spaces.We discuss:

In this presentation, Dr. Bredesen will provide you steps and tools to minimize and prevent Alzheimer's in your own environment.  Did you know that more women get Alzheimer's than breast cancer? Do you know the steps to take to protect yourself and your loved ones? Did you know 65% of adults with Alzheimer's are women and 60% of caregivers are women?   Did you know15+% of women in the US will get Alzheimer's?. Did you know noticeable symptoms can take 20 years to appear.? Do you know what the symptoms are?    Exclusive for Commonwealth Club Members: Post-program Conversation with Speaker After the first part of the program, members are invited to please join us for an intimate private conversation with Dr. Bredesen on Zoom. Club members who register will receive two links—one for the program itself and one for the private members-only post-program conversation with Dr. Bredesen. During that program, members can pose their own questions and delve more deeply into the topic. To become a member, for as little as $10 a month and have full access to all of our programming and podcasts.  Join here. About the Speaker: Dr. Bredesen graduated from Caltech and received his MD from Duke. He served as resident and chief resident in neurology at UCSF, then was a postdoctoral fellow with Nobel laureate Prof. Stanley Prusiner. He was founding president of the Buck Institute for Research on Aging. He is respected worldwide as the first to publish his groundbreaking work on the reversal of cognitive decline in patients with Alzheimer's disease. Dr. Bredesen authored three New York Times best sellers, and is currently a professor at UCLA. Learn more about your ad choices. Visit megaphone.fm/adchoices

Angela is joined by Dr. Dale Bredesen, who discusses the prevalence of Alzheimer's disease and the difference between Alzheimer's and other forms of dementia. He emphasises the importance of early detection and treatment, as Alzheimer's is a progressive disease that can be present for many years before symptoms appear. Dr. Bredesen explains the four phases of Alzheimer's and the potential for prevention and reversal of cognitive decline through lifestyle interventions.   KEY TAKEAWAYS Alzheimer's disease is a common and devastating form of dementia that affects millions of people worldwide. Alzheimer's is characterized by a progressive decline in cognitive function, including memory loss, difficulty with language and communication, and impaired daily functioning. Early detection and intervention are crucial in managing Alzheimer's disease. The earlier the treatment is initiated, the better the chances of preventing or reversing cognitive decline. Lifestyle factors such as diet, exercise, sleep, stress management, brain training, detoxification, and targeted supplements play a significant role in preventing and managing Alzheimer's disease. Hormone therapy, specifically bioidentical hormone replacement, may be beneficial for women experiencing menopause-related cognitive decline BEST MOMENTS "Your generation is the first generation that does not have to fear Alzheimer's." "We can pretty much prevent it or do early reversals in just about everyone." "We do see people even in late stages where we get some improvement, but they don't tend to come all the way back to normal." "Sleep is one of the ways that you stay sharp, that you improve your processing speed." VALUABLE RESOURCES Get a free snapshot of your health and personalised report at www.yourtotalhealthcheck.com Join The High Performance Health CommunityFree Fasting Guide - www.angelafosterperformance.com/fastingPodcast Shownotes - www.angelafosterperformance.com/podcasts Episode 212 - https://omny.fm/shows/high-performance-health/the-science-of-manifestation-how-to-use-neuroplast ABOUT THE GUEST Dale Bredesen, MD, received his undergraduate degree from Caltech and his medical degree from Duke University. He served as resident and chief resident in neurology at the University of California, San Francisco (UCSF) and as postdoctoral fellow in the laboratory of Nobel Laureate Professor Stanley Prusiner. He was a faculty member at UCLA from 1989 to 1994 and was then recruited by the Burnham Institute to direct the Program on Aging. In 1998, he became the founding president and CEO of the Buck Institute for Research on Aging and adjunct professor at UCSF. In 2013, he returned to the University of California, Los Angeles (UCLA) as director of the Easton Center for Alzheimer's Disease Research and he is currently a professor. The Bredesen Laboratory studies basic mechanisms underlying the neurodegenerative process and the translation of this knowledge into effective therapeutics for Alzheimer's disease and other neurodegenerative conditions, which has led to the publication of over 200 research papers. He is the principal investigator for the Alzheimer's Disease Research Center at UCLA. He established the ADDN (Alzheimer's Drug Development Network) with Dr. Varghese John in 2008, leading to the identification of new classes of therapeutics for Alzheimer's disease. His group has developed a new approach to the treatment of Alzheimer's disease, the MEND protocol, and this approach has led to the first description of a reversal of symptoms in patients with mild cognitive impairment (MCI) and early Alzheimer's disease. Dr. Bredesen is the author oftwo New York Times best sellers: The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Declineand The End of Alzheimer's Program. ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women's Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. Angela's BioSyncing®️ Blueprint is currently closed. Click here to get on the waitlist. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn

This episode of Longevity by Design features an interview with Dr. Eric Verdin—the CEO of The Buck Institute. The Buck Institute was the first center dedicated to aging research, and many discoveries within the aging field have come out of this research center. For this episode, Dr. Verdin, Dr. Blander, and Ashely Reaver sat down in person to discuss the latest updates in longevity research. Dr. Verdin shares his opinion on questions like “is aging a disease?” and “is there a maximum lifespan that humans will never surpass?” Dr. Verdin also discusses updates on the future of anti-aging drugs, including senolytics and metformin. To close the episode, Dr. Verdin gives life advice for what 5 things we can do on a regular basis to improve our health span.Listen to all episodes of Longevity by Design at https://info.insidetracker.com/longevitybydesign Episode timestamps: Introduction: (0:00–2:40) About the Buck Institute (2:40–8:00)Biological aging clocks (8:00–14:31)Public opinion and funding aging research (14:31–16:38) Is aging a disease? (16:38–19:35) Future of anti-aging drugs (19:35–25:25) Senescence and senolytics (25:25–29:42) The hallmarks of aging are interconnected (29:42–36:48) How medicine and public policy has improved life expectancy (36:48–40:50) How much of longevity is due to genetics? (40:50–44:52) Geographic location impacts life expectancy (44:52–51:08) Is there a maximum lifespan for humans? (51:08–56:40) Healthspan vs lifespan (56:40–60:04) The most important interventions to improve healthspan (60:04–1:06:04)  

This episode is truly a thought-provoking conversation about Alzheimer's and its unique impact on women with none other than the legendary Dr. Dale Bredesen (who is making his fourth appearance on the show). Dale Bredesen, MD, received his undergraduate degree from Caltech and his medical degree from Duke University. He served as resident and chief resident in neurology at the University of California, San Francisco (UCSF) and as postdoctoral fellow in the laboratory of Nobel Laureate Professor Stanley Prusiner. He was a faculty member at UCLA from 1989 to 1994 and was then recruited by the Burnham Institute to direct the Program on Aging. In 1998, he became the founding president and CEO of the Buck Institute for Research on Aging and adjunct professor at UCSF. In 2013, he returned to the University of California, Los Angeles (UCLA) as director of the Easton Center for Alzheimer's Disease Research and he is currently a professor.Dr. Stephanie and Dr. Bredesen delve into the fascinating topic of Alzheimer's as a preventable condition, emphasizing that this is the first generation with the power to make Alzheimer's truly optional. They explore the shift in the common presentation of Alzheimer's, particularly in women, highlighting the rise of subjective or mild cognitive impairment in 52-year-old women.As always, Dr. Stephanie and Dr. Bredesen provide actionable solutions for preventing and managing Alzheimer's, covering diet, exercise, sleep, supplementation, and testing. They introduce innovative blood tests, discuss the importance of a "cognoscopy," and even touch on dental health's role in brain health.Resources Mentioned:Reversal of Cognitive Decline: 100 Patients - https://www.omicsonline.org/open-access/reversal-of-cognitive-decline-100-patients-2161-0460-1000450-105387.htmlTranscriptional Effects of ApoE4: Relevance to Alzheimer's Disease - Transcriptional Effects of ApoE4: Relevance to Alzheimer's DiseaseReCODE: A Personalized, Targeted, Multi-Factorial Therapeutic Program for Reversal of Cognitive Decline. - https://pubmed.ncbi.nlm.nih.gov/34680464/Could Alzheimer's disease be a maladaptation of an evolutionary survival pathway mediated by intracerebral fructose and uric acid metabolism? - https://pubmed.ncbi.nlm.nih.gov/36774227/Reversal of cognitive decline: a novel therapeutic program - https://pubmed.ncbi.nlm.nih.gov/25324467/Reversing the effects of Alzheimer's Disease: Dr. Ron Geyer on NeuroEPO - https://medicine.usask.ca/news/2023/reversing-the-effects-of-alzheimers-disease-dr.-ron-geyer-on-neuroepo.phpDr. Bredesen's TedX talk - https://youtu.be/TzJSCttlQmc?si=sEC_psvctDR0XRkzDr. Bredesen's books - https://www.apollohealthco.com/books/KetoFLEX 12/3™ - https://ketoflex.apollohealthco.comEvanthea Dementia Reversal Trial - https://www.dementiareversaltrial.comInstagram - https://www.instagram.com/drdalebredesen/Episode Overview:0:00:00 Introduction0:05:42 Welcome to Dr. Dale Bredesen0:11:59 Factors driving the shift in Alzheimer's disease onset age0:15:41 COVID-19 and Alzheimer's disease risk0:21:28 The importance of addressing chronic conditions0:24:01 The role of metabolic health in cognitive decline0:25:40 The role of diet in Alzheimer's disease0:26:54 The postmenopausal women and cognitive decline0:35:05 Alzheimer's disease and genetic factors0:36:53 How we could confuse perimenopause with Alzheimer's0:44:39 ApoE4 and the evolution of hominids0:47:42 ApoE4 and its pro-inflammatory effect0:51:23 The limitations of targeting neurofibrillary tangles and plaques0:54:23 Evaluating the efficacy of drugs for Alzheimer's treatment1:04:39 Exploring the use of supplementation in the trial1:05:45 The seven fundamentals for maintain good brain health1:13:57 Importance of sleep hygiene and nasal breathing1:18:38 Tailoring sleep habits to circadian rhythms and environmental factorsWe'd like to thank our sponsors:Go to neurohacker.com/better to try Qualia Senolytic with a 100 day money back guarantee, and code BETTER will get you 15% off your order.Right now Levels is offering you an additional two free months off of the levels annual membership when you use the link levels.link/better.If you want to try Beam Minerals for yourself, head over to beamminerals.com/better for 20% off of the entire store.