Podcasts about buck institute

A pioneer in aging research has died. Tom Johnson proved that genes affect longevity. His work at the University of Colorado spawned an entire scientific field, and led to breakthroughs in diseases like Alzheimer's. For our series Aging Matters, we learn about Johnson's legacy. Simon Melov worked with him as a post-doc in the 1990s. Melov's now a professor at California's Buck Institute for Research on Aging. Then, former Mesa County Clerk Tina Peters is free, but her story's far from over. We get perspective from Purplish.

Dale Bredesen is the senior director of the Precision Brain Health Program at Pacific Neuroscience Institute and also the founding CEO of the Buck Institute. He also has authored a number of books, including, most recently, The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime and The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline. Greg and Dale discuss Dale's “network insufficiency” view of Alzheimer's that shifts focus from plaques alone to a balance of synaptic “supply and demand.” He argues the brain switches from connection to protection under chronic insults, which are microbes, inflammation, toxins, metabolic syndrome, sleep apnea, and poor energetics. Dale highlights tau phosphorylation as part of an antimicrobial response and APOE4 as a pro-inflammatory risk gene with evolutionary benefits.  They also discuss diet, insulin resistance, exercise, sleep metrics, stress, and the case for prevention and combined approaches. *unSILOed Podcast is produced by University FM.* Episode Quotes: The brain's shift from connection to protection 07:33: We see it at every level in the brain. We see it at the molecular level, that you have a connections program and a protection program. We see it at the cellular level, we see it at the tissue level, and even at the organismal level. You can see when people—and you can actually measure this now with blood tests—is someone on the connection side or on the protection side? So therefore, when you have insults, and over our lives it's typically various microbes, it's leaky gut, it's sleep apnea, it's various toxins we're exposed to, air pollution, mercury, microplastics, unfortunately, anesthetic agents, horrible food, all these things that are demanding you be in that protection mode, then ultimately you cannot support five hundred trillion synapses. The supply-and-demand theory of cognitive decline 30:08: Anything that lowers your supply or increases your demand is going to increase your risk for cognitive decline. On the other hand, anything that lowers the demand and increases the supply is going to be a risk reducer, whether it's Omega-3s, whether it's resolvins, whether it's exercise, whether it's better sleep, more deep sleep, less sleep apnea. There are dozens and dozens and dozens of things. So, for the first time, our armamentarium to reduce risk and reverse decline is huge. Now we can look at these different pieces and manipulate them so that we get better and better outcomes. Are doctors the antithesis to Silicon Valley? 49:23: Well, here's the thing. Doctors are the antithesis to Silicon Valley. Silicon Valley is always looking for what's disruptive, what's next, how can we go further, do more. And to be fair, it's because typically those things are not going to kill you. Whether you, like, get your package from Amazon a little faster, it's not going to kill you. Whereas the doctors are told, “Listen,” just like being in the army, “If you do not do what we tell you, someone's going to die.” And that's fair, okay. But they're very poor, therefore, at innovation. If you go back to history, it's scary, scurvy—it was understood what to do about scurvy in the sixteen hundreds. It wasn't generally accepted until the nineteen hundreds. So thousands and thousands and thousands of people died needlessly because doctors said, “No, we do not believe this.” And the same thing, frankly, is happening now with Alzheimer's disease. Show Links: Recommended Resources: Doctored: Fraud, Arrogance, and Tragedy in the Quest to Cure Alzheimer's Prion Richard Feynman Alzheimer's Disease Amyloid Apolipoprotein E KAATSU Guest Profile: Faculty Profile at Pacific Neuroscience Institute Profile at Apollo Health Social Profile on Instagram Guest Work: Amazon Author Page The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline The End of Alzheimer's Program: The First Protocol to Enhance Cognition and Reverse Decline at Any Age The First Survivors of Alzheimer's: How Patients Recovered Life and Hope in Their Own Words TEDx Talk: A precision approach to end Alzheimer's Disease Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

What if the longevity revolution isn't really a science problem, but a human one we're completely unprepared for?In this episode of Health Longevity Secrets, Robert Lufkin MD sits down with David Donnelly — the award-winning filmmaker behind "Forever Young" (winner of the Mill Valley Film Festival Audience Award). David spent three years across three continents embedded with the world's leading longevity scientists — the Buck Institute, Dr. Eric Verdin, Dr. Steve Horvath, and more — and came back with the uncomfortable question no one wants to ask: do we actually want to live forever in the world we've built?CHAPTERS:00:00 — Introduction02:32 — From Pre-Med to Filmmaker: Donnelly's Origin Story04:58 — Dr. Eric Verdin on Multifactorial Aging09:34 — The 30-Minute Walk That Cuts Disease 40%10:33 — Why 93% of How You Age Is Lifestyle13:50 — The Horvath Epigenetic Clock Explained14:14 — Healthspan vs Lifespan: The 122-Year Cap14:54 — Age Looping and Epigenetic Reprogramming15:57 — Bryan Johnson and the Wild Side16:29 — Do We Actually Want to Live Forever?19:03 — The Loneliness Epidemic Is a Pack a Day21:42 — Death Doula Katie Rose and the Death Positive Movement24:29 — Reframing Retirement for 40 More Years28:08 — Science vs Commercial Hype in Longevity30:49 — Why Normal Bloodwork Isn't Good Bloodwork31:33 — What a True Longevity Clinic Does33:58 — Meet the Producers: Dr. Johnson and Dr. Lewis42:06 — Final Takeaway: Start the JourneyKEY TAKEAWAYS:• Only ~7-10% of longevity is genetic — 93% is lifestyle and epigenetics• A 30-minute walk a day reduces chronic disease risk by 30-40%• The Horvath epigenetic clock makes biological age measurable in real time• Current lifespan is biologically capped near 122 — the real opportunity is healthspan• Chronic loneliness harms your body at the same rate as smoking a pack a day• "Normal" bloodwork often means sick — optimal is a different number• The existential questions — meaning, purpose, death — are missing from the longevity conversationSTUDIES & SOURCES MENTIONED:• "Forever Young" — the documentary• Dr. Eric Verdin — Buck Institute for Research on Aging• Dr. Steve Horvath — epigenetic clock (Nature Aging)• US Surgeon General Advisory on loneliness (2023)• OSK partial reprogramming and lifespan extension (Nature, 2020)• Ray Kurzweil — "The Singularity Is Nearer" (2024)⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every Tuesday & Thursday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

While the longevity field is filled with dubious claims and junk science, there have been some truly remarkable advances that will have an impact on how we can live longer and stay healthier. In this episode, Kara unpacks some of them with Dr. Eric Verdin, the president and CEO of the Buck Institute for Research on Aging in Novato, California. The Buck Institute was the first of its kind, and it's at the forefront of all the latest research on longevity.  Later she speaks to Dr. Vinod Balachandran, attending physician and director of The Olayan Center for Cancer Vaccines at Memorial Sloan Kettering in New York. He'll explain his research into mRNA vaccines and their potential to treat and possibly cure pancreatic cancer.  Questions? Comments? Email us at on@voxmedia.com or find us on YouTube, Instagram, TikTok, Threads, and Bluesky @onwithkaraswisher. Learn more about your ad choices. Visit podcastchoices.com/adchoices

For decades, aging was seen as inevitable — a slow and irreversible decline. But a growing number of scientists now believe we may be entering a turning point, with research increasingly focused on extending not just how long we live, but how well we live.In the documentary Forever Young, filmmaker David Donnelly — alongside producers Dr. James Johnson and Dr. Thomas Lewis — explores the rapidly evolving world of longevity science, from biological clocks and AI-driven research to the power of lifestyle, purpose, and social connection.The film also confronts some of the field's biggest questions: what aging actually is, whether it should be treated as a disease, and who stands to benefit if the science succeeds. In this conversation with Peter Bowes, Donnelly reflects on skepticism, scientific disagreement, and why he believes humanity may already be living through a longevity revolution.--Learn more about Forever Young: The end of aging has just begunApple TV Pre-order | Official Website | Substack | Instagram | X | Facebook | YouTube | Watch the Trailer--DISCLOSURE: This podcast is supported by affiliate arrangements with a select number of companies. We have arranged discounts on certain products and receive a small commission on sales. The income helps to cover production costs and ensures that our interviews remain free for all to listen. Visit our SHOP for more details: https://healthspan-media.com/live-long-podcast/shop/Fit, Healthy & Happy Podcast Welcome to the Fit, Healthy and Happy Podcast hosted by Josh and Kyle from Colossus...Listen on: Apple Podcasts SpotifyEnergyBits algae snacksA microscopic form of life that could help us age better. Use code LLAMA for a 20 percent discountPartiQlar supplementsEnhance your wellness journey with pure single ingredients. 15% DISCOUNT - use code: MASTERAGING15Disclaimer: This post contains affiliate links. If you make a purchase, I may receive a commission at no extra cost to you.Support the showThe Live Long and Master Aging (LLAMA) podcast, a HealthSpan Media LLC production, shares ideas but does not offer medical advice.  If you have health concerns of any kind, or you are considering adopting a new diet or exercise regime, you should consult your doctor.

Send us Fan MailWhat if the future of medicine isn't about treating disease…but detecting it 20 years before symptoms ever appear? Dr. Julie Chen, MD is helping lead one of the newest precision-health companies trying to build that future.Dr. Julie Chen, MD is a physician operating at one of the most interesting intersections in modern medicine: rigorous clinical research, precision longevity medicine, integrative care, and the rapidly evolving world of AI-driven health optimization.Dr. Chen graduated Summa Cum Laude and Phi Beta Kappa from the University of Rochester before earning her M.D. with Distinction in Research and Alpha Omega Alpha honors from the university's School of Medicine. She went on to complete her internal medicine residency and later trained in integrative medicine under Andrew Weil at the University of Arizona Center for Integrative Medicine.Over the course of her career, Dr. Chen has conducted research and published work through institutions including the U.S. Food and Drug Administration, National Institutes of Health, National Cancer Institute, Mount Sinai School of Medicine, and University of Southern California.Dr. Chen has also become a prominent operational leader in the longevity industry, serving in executive medical roles at companies including Human Longevity, Inc., Vitagene, and now as Chief Medical Officer of Radence ( https://radence.com/ ) and Sidestep Health AI. She additionally serves as a Leadership Circle Advisor for the Buck Institute for Research on Aging.What makes Dr. Chen particularly compelling is that she has seen the longevity ecosystem from nearly every angle: academic medicine, FDA-level research, integrative clinical care, Silicon Valley health-tech, and AI-enabled prevention.In today's conversation, we'll explore where the science around longevity is genuinely promising, where the hype may be outrunning the evidence, how precision medicine is shifting toward early disease interception, and what responsible longevity medicine should actually look like in an era increasingly driven by consumer demand and social-media-driven health trends.#Longevity #Peptides #PrecisionMedicine #Healthspan #DrJulieChen #PreventiveMedicine #Biohacking #Aging #DiseaseInterception #GLP1 #LongevityMedicine #AIHealthcare #IntegrativeMedicine #HealthOptimization #HumanLongevity #FutureOfMedicine #MetabolicHealth #PreventiveHealth #Biotech #CraigVenter #Wearables #Biomarkers #Genomics #RadenceSupport the show

In this episode, we sit down with Eric Verdin, CEO of the Buck Institute, one of the world's leading institutes dedicated to aging and longevity research.Eric has often been associated with a more rigorous and incremental approach to extending human lifespan, focused on scientific validation, measurable progress, and improving healthspan before chasing more radical ambitions. In contrast, the broader life extension movement has become known for pushing bold visions of indefinite lifespan and extreme human enhancement.But as this conversation unfolds, it becomes clear that these approaches are far less opposed than they may seem.We explore the relationship between moonshots and incremental progress, the role of scientific rigor in advancing longevity, and the institutional incentives that often reward performative radicalism over real-world results. The conversation also touches on regulation, public perception, and the challenge of turning longevity from a speculative idea into a field capable of delivering tangible benefits to people today.Rather than framing ambition and rigor as competing forces, this episode examines why both are necessary to meaningfully move the field forward. This is a public episode. If you would like to discuss this with other subscribers or get access to bonus episodes, visit www.infinitacitytimes.com

As part of the US HUPO sponsored "All the Parts", Ben and Ben sat down to talk with Dr. Charles Schurman, Buck Institute for Research on Aging.keywords: osteoporosis; Haversian system; lacunar-canalicular system; perilacunar/canalicular remodeling; Deadpool 2; Unbreakable (2000)

In this episode, Dr. Karen Litzy hosts Dr. Sherry Zhang, an expert in obesity genomics, personalized nutrition, and longevity science. They explore how genetics and AI are transforming healthspan strategies, empowering practitioners to deliver more precise, actionable advice to their patients. Whether you're a healthcare provider or health-conscious individual, discover how to leverage DNA insights and technology to enhance longevity and quality of life. In this episode: ·       Dr. Sherry Zhang shares her journey from classical musician in China to leading health tech innovator focused on longevity. ·       The limitations of one-size-fits-all nutrition and how genetics reveal why personalized approaches are essential. ·       How genetic insights help combat health misconceptions and promote empowerment rather than excuses. ·       The role of AI, multi-omics, and federated data models in revolutionizing health monitoring and prevention. ·       Practical ways clinicians and practice owners can incorporate genetic and digital health data into patient care today. ·       Using insights like sleep quality, grip strength, and heart rate variability as early markers of health decline. ·       The importance of a proactive, trajectory-based view of health spanning decades, not just episodes of illness. ·       Strategies to build trust in privacy-preserving AI tools and navigate data regulation challenges. ·       The future of healthspan extension: living vibrantly into your 120s and beyond. Timestamps:  00:00 – Welcome and Dr. Sherry Zhang's transition from musician to health tech innovator 01:19 – The limitations of traditional nutrition models revealed through genomics 01:51 – Why one-size-fits-all doesn't work—genetic variations in weight management 02:44 – How genomics can correct misconceptions and empower health choices 04:09 – The importance of genetic pride and understanding evolution's role in our health 05:16 – Avoiding genetic excuses: personal responsibility in health behavior 06:00 – Building personalized nutrition profiles with GenoPallet 08:07 – How genetic insights influence patient motivation and adherence 10:01 – The power of identity and self-perception in health behavior change 11:08 – Impact of personalized data on engagement, especially in metabolic health 12:03 – How to interpret sensitivity to substances like caffeine and alcohol 13:24 – The significance of metabolizer status—fast vs. slow—on lifestyle choices 14:32 – Defining health span practically: years lived in good health, not just disease-free 15:12 – Monitoring long-term health trajectories vs. snapshots 16:10 – The shift from reactive to proactive healthcare practices 17:10 – Integrating multi-layered omics and continuous data streams for longevity 18:22 – The role of resilience and capacity in health monitoring 20:22 – Early biomarkers for health decline and how wearable tech can help 21:51 – Implementing AI in practice: opportunities and challenges for non-data scientists 23:28 – Privacy and security: federated data models safeguarding personal health info 24:41 – The future of AI in personalized prevention and health management 28:39 – Envisioning healthcare in 20 years: living vibrantly into your 120s 30:40 – Sherry's advice for her younger self—cultural learning and lifelong growth 37:04 – Connecting with Dr. Sherry Zhang and accessing her resources   Resources & Links: ·       Yisharijang.com – Dr. Zhang's official website ·       The Founder Effect (Book) – her memoir exploring her journey and scientific insights ·       Genopallet – Personalized nutrition based on DNA ·       Buck Institute for Research on Aging – Leading longevity science research ·       Houseband Horizons – AI-powered health management platform ·       Federated Learning – Privacy-preserving AI technology Connect with Dr. Sherry Zhang: ·       LinkedIn ·       Substack ·       Instagram ·       X   More About Dr. Zhang: Dr. Yi Sherry Zhang is an obesity genomics scientist, health tech entrepreneur, and leader in personalized nutrition. She is the founder of GenoPalate, a U.S.-based nutrigenomics company that uses DNA insights to help individuals make more informed, personalized food choices. With nearly two decades of experience bridging science and real-world health applications, she currently serves as Executive Director of External Strategy & Partnerships at the Buck Institute's Price Lab, where she focuses on advancing data-driven approaches to healthspan and longevity. Dr. Zhang is also the author of the Amazon bestseller The Founder Effect and a frequent speaker at major industry conferences including HLTH and the Precision Medicine World Conference. Jane Sponsorship Information: Book a one-on-one demo here Mention the code LITZY1MO for a free month Follow Dr. Karen Litzy on Social Media: Karen's Instagram Karen's LinkedIn Subscribe to Healthy, Wealthy & Smart: YouTube Website Apple Podcast Spotify SoundCloud Stitcher iHeart Radio

As beauty and wellness industry insiders are well aware, the supplement space has exploded in size and scope over the past decade.  Stiff competition has driven new ways for brands, retailers and adjacent tech companies to stand out, from third-party certification to award programs, and more recently, the advent of AI-powered wellness chatbots. Last year, Thorne became a first-mover with the launch of Taia, a first-of-its-kind generative AI advisor that lives on Thorne's homepage. “In the first six months, [Taia has fielded] over 200,000 messages and more than 350,000 product and lifestyle recommendations,” said Nathan Price, PhD., chief science officer of Thorne. “We get about 8% higher average order value for those who use Taia versus those who just visit Thorne's [website].”  Thorne is a supplement category leader launched in 1984 and acquired by L Catterton equity group in 2023 for approximately $680 million. The brand has more than 300 SKUs but no hero product, which is one reason Taia exists. “My primary thesis is that the No. 1 thing we can do to help Thorne as a company is to help the Thorne customer,” Dr. Price said. “If Taia and personalization can meaningfully make it so that the person gets the health outcome they were looking for, we think [Taia is] going to have a very big ROI.”  Dr. Price oversaw the creation of Taia, which is trained on Thorne's internal knowledge database, powered by a team of researchers and doctors, and AI foundational knowledge of health and wellness. For example, Taia can provide insights into common queries around things like gut health, itchy skin or exhaustion. It then provides personalized supplement recommendations, and lifestyle and nutrition tips, and helps users locate informational blog posts or product information on Thorne's site.  While the practical uses of Taia are somewhat obvious, Dr. Price is also a thought leader on the future of AI-powered health and wellness. He believes that every wellness brand should begin investing now or be left in the dust in the next two years.  “It's like deciding not to have a website and be plugged into the Internet when that started becoming a thing in the late 90s,” Dr. Price told Glossy. “It's absolutely table stakes [because] this is how most people are getting information, and in the future, it's going to radically [increase].”  Dr. Price's career sits at the forefront of where longevity and healthspan research intersects with evolving technologies like AI and AI companions.  He is the author of the 2023 bestselling book “The Age of Scientific Wellness,” has published over 200 scientific papers, and is a professor and co-director of the Center for Human Healthspan at the Buck Institute for Research on Aging, a California-based research institute focused solely on aging. He's also been the CSO at Thorne for more than four years. In today's episode, Dr. Price sat down with host Lexy Lebsack to break down the strategy, implementation and future of generative wellness chatbots like Taia, as well as big picture thoughts on the future of AI and wellness, and how brands must future-proof their businesses in the fast-moving AI revolution.

Educational leadership is a tough challenge at the best of times, with many pressures from all sides. But particularly now, with so much shifting, high levels of uncertainty, and polarising issues at play, it's arguably an even rougher sea to navigate. In such a context, my guest this week has done an amazing job of gathering vital insights from 67 amazing education leaders around the world, herself included, to bring some collective wisdom to bear on the subject. Jennifer D. Klein is an author and former head of school with extensive international experience and over 30 years in education--including 19 in the classroom. She is a product of experiential project-based education herself, and she lives and breathes the student-centred pedagogies used to educate her. She became a teacher during graduate school in 1990, quickly finding the intersection between her love of writing and her fascination with educational transformation and its potential impact on social change. She spent nineteen years in the classroom, including several years in Costa Rica and eleven in all-girls education, before leaving the classroom to support educators' professional learning in public, private, and international schools. Motivated by her belief that all children deserve a meaningful, relevant education like the one she experienced herself, and that giving them such an education will catalyze positive change in their communities and beyond, Jennifer strives to inspire educators to shift their practices in schools worldwide.Jennifer has a broad background in global education and global partnership development, student-centered curricular strategies, diversity and inclusivity work, authentic assessment, and experiential, inquiry-driven learning. She has facilitated workshops in English and Spanish on four continents, providing the strategies for high-quality, globally connected project-based learning in all cultural and socioeconomic contexts, with an emphasis on amplifying student voice and shifting school culture to support such practices. She is committed to intersecting global student-centered learning with culturally responsive and anti-racist teaching practices, and her experience includes deep work with schools seeking to address equity, take on brave conversations, build healthier community, and improve identity politics on campus. Jennifer's first book, The Global Education Guidebook: Humanizing K–12 Classrooms Worldwide Through Equitable Partnerships, was published in 2017, and her second book, The Landscape Model of Learning: Designing Student-Centered Experiences for Cognitive and Cultural Inclusion, was released in 2022. Her third book, Taming the Turbulence in Educational Leadership: Doing Right by Learners without Losing your Job, to be released in September, 2025, is based on interviews with 67 educational leaders around the world who are facing resistance to practices they know are good for learners. Jennifer's experiences as a head of school in Colombia provide a through line as she explores the strategies leaders are using to manage resistance.Jennifer has worked with organizations such as the Buck Institute for Education, the Center for Global Education at the Asia Society, The Institute for International Education, Fulbright Japan, What School Could Be, the Centre for Global Education, TakingITGlobal, and the World Leadership School. Most recently, she served as Head of School at Gimnasio Los Caobos (Bogotá, Colombia) for three years, where she was able to put her educational thinking into practice with profound impact on the quality of student learning and their growth as agents of change.Links:Jennifer's website: https://www.principledlearning.org/ LinkedIn: https://www.linkedin.com/in/jdeborahklein/

Aging reshapes the immune system in two fundamental ways: it alters the proportions of different immune cell types circulating in the blood, and it induces molecular changes within each individual cell. For years, researchers have struggled to disentangle these two intertwined processes using standard “bulk” measurements, which average signals across millions of cells and obscure what is happening at the single-cell level. A new research paper, titled “Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV” published in Volume 18 of Aging-US by researchers at the Buck Institute for Research on Aging in California, the University of Southern California, and the University of Copenhagen, introduces an innovative solution. The team of Alan Tomusiak, Sierra Lore, Morten Scheibye-Knudsen, and corresponding author Eric Verdin, developed a novel tool called Tictock (T immune cell transcriptomic clock) that uses single-cell RNA sequencing to separately measure systemic and cell-intrinsic components of immune aging, and then applied it to understand how COVID-19 and HIV affect T cells. Full blog - https://aging-us.org/2026/03/tictock-a-single-cell-clock-measures-immune-aging-in-viral-infections/ Paper DOI - https://doi.org/10.18632/aging.206353 Corresponding author - Eric Verdin - EVerdin@buckinstitute.org Abstract video - https://www.youtube.com/watch?v=_r3AF7OrgKY Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206353 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, transcriptomic clock, aging biomarkers, systemic aging, intrinsic aging To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Send a textDr. Dan Pardi is the Chief Health Officer at Qualia Life Sciences, where he leads health education, protocol design, and health-improvement strategies. His work centers on translating cutting-edge science into actionable information and programs that support health span optimization and peak performance. Previously, Dan founded humanOS.me, a digital health platform developed with over 100 health-science professors. Its podcast, humanOS Radio, became the official podcast of the Sleep Research Society and a content partner of the Buck Institute for Research on Aging.He also served as Chief Health Architect at Restore Hyper Wellness, where he led new product strategy and served as key authority for intervention sciences.Through Vivendi Health, Dan provides bespoke consulting to individuals and organizations facing unique health challenges. He holds a PhD in Cognitive Neuroscience from Leiden University and Stanford, and a Master's in Exercise Physiology from Florida State.He's spoken at TEDx and the Institute for Human Machine Cognition, among others.Find Dr. Pardi at-https://www.qualialife.com/Find Boundless Body at- myboundlessbody.com Book a session with us here!

BUFFALO, NY — February 19, 2026 — A new #research paper was #published in Volume 18 of Aging-US on February 8, 2026, titled “Single-cell transcriptomics reveal intrinsic and systemic T cell aging in COVID-19 and HIV.” In this study, co-first authors Alan Tomusiak from the Buck Institute for Research on Aging and the University of Southern California, and Sierra Lore from the Buck Institute for Research on Aging and the University of Copenhagen, together with corresponding author Eric Verdin from the Buck Institute for Research on Aging, developed a new single-cell transcriptomic clock called T immune cell transcriptomic clock (Tictock) to measure aging in specific immune cells. Immune aging increases susceptibility to infection, cancer, and chronic inflammatory disease. Most aging clocks, used to measure it, rely on bulk measurements from mixed cell populations. As a result, they cannot determine whether age-related signals reflect shifts in cell proportions or true molecular aging within defined immune cells. To address this limitation, the research team used single-cell RNA sequencing, a method that measures gene expression in individual cells. They analyzed nearly two million immune cells from the blood of healthy adults to develop Tictock. This tool integrates automated classification of six canonical T cell subsets with cell-type specific age prediction models. This design enables the separation of systemic aging, reflected by changes in cell proportions, from intrinsic aging, which occurs within individual cells. When the team applied Tictock to patients with acute COVID-19, they found two clear effects. First, COVID-19 altered T cell composition, including significant reductions in naïve CD8 and naïve CD4 T cells. Second, the infection increased the biological age of naïve CD8 T cells. In people living with HIV who were receiving long-term antiretroviral therapy, T cell proportions remained largely stable. However, naïve CD8 T cells still showed signs of accelerated aging. The study also uncovered shared biological pathways linked to immune aging. Many of the genes that predicted age were involved in ribosomes, the structures that help cells produce proteins. The researchers also observed that older immune cells often had shorter average transcript lengths, a feature previously linked to aging. These findings suggest that changes in protein production and gene regulation play an important role in immune decline. “Gene Ontology enrichment of 209 genes shared across six clock models identified common pathways including the cytosolic small ribosomal subunit, TNF receptor binding, and cytosolic ribosome components.” Overall, Tictock was designed to measure relative aging within defined T cell populations rather than overall biological aging. By distinguishing systemic from cell-intrinsic immune aging, it provides a clearer understanding of how viral infections such as COVID-19 and HIV reshape immune function. This approach enables the study of immune aging at single-cell resolution and may support improved immune risk assessment in clinical and research settings. DOI - https://doi.org/10.18632/aging.206353 Corresponding author - Eric Verdin - EVerdin@buckinstitute.org Abstract video - https://www.youtube.com/watch?v=_r3AF7OrgKY Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit https://www.Aging-US.com​​. MEDIA@IMPACTJOURNALS.COM

In this episode of Longevity by Design, host Dr. Gil Blander sits down with Dr. Nathan Price, Professor and Co-Director at the Buck Institute for Research on Aging. Together, they explore how systems biology, artificial intelligence, and deep health data are changing the way we approach aging and prevention. Nathan explains why looking at single biomarkers falls short and why a network view of biology gives a clearer path to understanding disease and resilience.Nathan shares how new tools, like genetics, proteomics, and the emerging field of digital twins, can help predict disease risk years in advance and guide more effective, personalized interventions. He also discusses how integrating data from wearables, blood tests, and the microbiome can help people move from reactive medicine to proactive health decisions, allowing for interventions that fit the individual.The conversation highlights the promise and practical limits of current technologies, the trade-offs involved in optimizing health, and the power of AI to accelerate both research and personal health journeys. Nathan makes a strong case for the unique biology each person brings to the table and shows how the tools available today can help anyone take charge of their own healthspan in ways not possible before.Guest-at-a-Glance

What if the contract you didn't get was actually the answer to your prayer? In this episode, Eric Collett shares how he helps entrepreneurs and executives optimize their brain health to function at an elite level. His work goes upstream, identifying the trajectory decades before diseases like Alzheimer's show symptoms, because most people don't realize that Alzheimer's and other neurodegenerative diseases generally start decades before the first symptoms appear. Eric's team has developed the Enhance Protocol, helping clients improve brain function by 20-30% so they can learn faster, understand new technologies more rapidly, find words faster, have more stable mental health, and prevent cognitive decline to stay in the game longer. He reveals losing what would've been his biggest contract in Arizona. After two weeks of silence following a handshake agreement, he prayed: "If it's not the right thing, please don't let it happen." The CEO called to say they'd met nurse practitioner Randy Vawdrey who could actually reverse cognitive decline. Eric told them "You should work with Randy, that's a huge opportunity." Months later, Randy called to collaborate. They met at 6pm and talked until after midnight going through a Bible-sized stack of research. Within six months, Eric asked Randy to become his business partner, a relationship that put him through an intentional crash course in med school for years.   [00:05:20] Optimal Brain Health is Required Believes optimal brain health required for optimal results in business and life Brain is like hardware, everything we're learning and striving to do is like software Loading new software on crummy old dysfunctional hardware never gets great results Good brain health needed for better relationships, better business [00:06:00] Improving Brain Function by 20-30% Team developed organized system to identify root cause issues affecting brain performance Make specific recommendations, track objectively Help people improve brain function by 20-30% Can learn faster, understand new technologies more rapidly, find words faster, have more stable mental health [00:07:20] Who They Serve All ages: younger people with traumatic brain injuries, people in 30s with brain fog People 50-80 noticing things aren't what they used to be Especially focus on entrepreneurs and executives who want to function at elite level Most people miss opportunity to quantify it objectively instead of just guessing [00:10:00] Gary Plummer: From Doorknob to Stage Gary Plummer played linebacker for San Francisco 49ers, won Super Bowl ring Shortly after retiring, couldn't remember how to install doorknob (had done many times) Could go from zero to fighting mad at drop of hat, had to isolate from people Wouldn't drive on freeways, wouldn't travel without handler to meet at airport [00:11:20] The Transformation Eric's team helped take Gary's cognitive scores from 58th percentile to 86th percentile Several years later, now above average overall on tests Got to watch Gary step on stage at Forever Young Foundation event in Arizona Had quit speaking because he would lose train of thought, now presenting confidently [00:13:40] Alzheimer's Starts Decades Before Symptoms Nationally recognized expert, spoken in 39 of 50 states to healthcare professionals Alzheimer's and diseases like Parkinson's generally start decades before first symptoms We've grown up in "sick care system" that waits till you have serious problem 40-95% of Alzheimer's cases believed to be preventable [00:18:00] Think of Your Brain as a Boat When things are good, riding high in water, moving at top speed When not good, starting to take on water Common for people to get forgetful as they get older, but that's not normal, that's evidence of disease Brain health is never about one thing, it's multifactorial (80-100 things) [00:19:20] One Client: 68th to 99th Percentile Client is 42 years old, wrote LinkedIn article about experience Went from 68th percentile in cognitive functioning to 99th percentile Getting better results in life and business today Has lot more assurance he's changed trajectory for tomorrow [00:20:40] The Contract I Didn't Get Early 2017, started A Mind For All Seasons as solopreneur Opportunity to work with Arizona company designing memory care program for entire portfolio Met with owners, left with handshake agreement, supposed to get contract in couple days Couple days turned into more than two weeks [00:22:00] The Prayer Prayed: "I want this to happen, this would make my year" "If it's not the right thing, please don't let it happen" "I promise I will be grateful, I may not understand it, but I can be grateful in all things" Within day or two, CEO called [00:22:20] Meeting Randy Vawdrey CEO said they met nurse practitioner with advanced training in neurodegenerative diseases Randy had done fellowship with Dr. Bredesen at UCLA, Buck Institute for Research on Aging Dr. Bredesen's 2014 paper "Reversal of Cognitive Decline" showed 9 out of 10 patients with remarkable improvement Company said "We can't afford both Randy and you, we're going to work with Randy" [00:23:40] "You Should Work With Randy" Eric told them "You should, that's a huge opportunity, no one's doing that" They suggested "You should call Randy, he lives in Idaho like you do" Eric thought "I'm not gonna call Randy, I don't have time, I just lost biggest contract" Hustled for couple months [00:24:20] Randy Called Randy called out of the blue, said company wanted him to train staff "I'm a clinician, I don't do that, I want to explore collaborating" Eric was driving through Randy's part of state next week, said "Why don't we get together?" Went to Randy's house at 6pm, was there till after midnight [00:25:00] The Bible-Sized Stack of Research Randy brought out huge Bible-sized stack of research, slammed it on coffee table Started going through footnotes of the footnotes, what he'd learned with real patients Eric left 100% recognizing they could make far bigger difference Had agreement to split the contract, neither would make much money [00:25:40] "Will You Be My Business Partner?" Within six months Eric said "Randy, what are we doing dating? We need to work together" "Will you be my business partner? Let's go all in on this" All these years later still working together, still innovating Randy put Eric through intentional crash course in med school [00:26:00] The Education Every Friday and Monday morning at 7am for a few years, met for hour or two Randy taught Eric how to read labs, physiology and science behind everything Continued teaching ever since "Short of my own family, he has done more to affect my life than any human on the planet" [00:27:40] The Vision: Impact a Million Lives Current goal: impact another million lives in next two to three years Eight billion people on planet, everybody has brain, everybody needs optimal brain health Majority of Americans not metabolically healthy Alzheimer's nicknamed "diabetes of the brain" [00:32:40] Social Engagement Reduces Cognitive Decline From research standpoint, being more socially engaged reduces risk of cognitive decline Not only better in business and more joy in life, it's better for your brain Prioritizing relationships and being connected matters deeply for cognitive and mental health   KEY QUOTES "Diseases like Alzheimer's disease, which I'm a nationally recognized expert in. I've literally talked in 39 of the 50 states to healthcare professionals. Most people don't realize that Alzheimer's disease and other neurodegenerative diseases like Parkinson's generally start decades before the first symptoms ever show up." - Eric Collett "I prayed and I literally said, I want this to happen. This would just make my year. If it's not the right thing, please don't let it happen, and I promise that I will be grateful. I may not understand it, but I can be grateful in all things." - Eric Collett "Being more socially engaged actually reduces the risk of cognitive decline. So not only are things better in business, and not only do you have more joy in life, it's actually better for your brain." - Eric Collett CONNECT WITH ERIC COLLETT 

BUFFALO, NY — December 12, 2025 — A new #research paper was #published in Volume 17, Issue 11 of Aging-US on November 14, 2025, titled “Methylglyoxal-induced glycation stress promotes aortic stiffening: putative mechanistic roles of oxidative stress and cellular senescence.” The study was led by first authors Parminder Singh of the Buck Institute for Research on Aging and Ravinandan Venkatasubramanian of the University of Colorado Boulder, with senior contributions from corresponding authors Pankaj Kapahi (Buck Institute for Research on Aging) and Zachary S. Clayton (University of Colorado Boulder and University of Colorado Anschutz Medical Campus). The researchers investigated how methylglyoxal (MGO), a toxic byproduct that builds up in blood vessels with age or metabolic dysfunction like diabetes, contributes to artery stiffening. Their findings are especially important to aging and diabetes-related cardiovascular risk. Aortic stiffening, which reduces the flexibility of the body's largest artery, is a key predictor of cardiovascular disease in older adults. The research team used young and aged mice to study how MGO affects vascular health. In young mice, chronic exposure to MGO increased aortic stiffness by 21%. However, when treated with Gly-Low, a supplement containing natural compounds such as nicotinamide and alpha-lipoic acid, this stiffening was completely prevented. Gly-Low also reduced the buildup of MGO and its harmful byproducts, particularly MGH-1, in both blood and tissue. “Aortic stiffness was assessed in vivo via pulse wave velocity (PWV) and ex vivo through elastic modulus.” The research showed that MGO's damage goes beyond structural changes. It also caused the endothelial cells that line blood vessels to enter senescence, a state in which cells stop dividing and begin releasing inflammatory signals. This led to lower levels of nitric oxide, a molecule essential for blood vessel relaxation. In human vascular cells in lab culture, Gly-Low reversed these aging-like changes and restored nitric oxide production. In older mice, which naturally develop stiffer arteries, Gly-Low treatment during four months significantly reduced stiffness and lowered MGO and MGH-1 levels. This suggests that Gly-Low may help slow or even reverse vascular aging by reducing glycation stress. The study also identified the glyoxalase-1 pathway as a critical mechanism. This is a natural detox system that helps clear harmful molecules like MGO. Gly-Low appeared to boost this pathway. When the pathway was chemically blocked, Gly-Low's protective effects disappeared, confirming its role in the process. Overall, the findings highlight glycation stress as a modifiable contributor to vascular aging. The results suggest that natural compound-based therapies, like Gly-Low, may offer a potential strategy to protect arteries from age- and diabetes-related damage. DOI - https://doi.org/10.18632/aging.206335 Corresponding authors: Pankaj Kapahi - pkapahi@buckinstitute.org; Zachary S. Clayton - Zachary.Clayton@cuanschutz.edu Abstract video: https://www.youtube.com/watch?v=i_rtq8eIb8c Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media: Bluesky - https://bsky.app/profile/aging-us.bsky.social ResearchGate - https://www.researchgate.net/journal/Aging-1945-4589 X - https://twitter.com/AgingJrnl Facebook - https://www.facebook.com/AgingUS/ Instagram - https://www.instagram.com/agingjrnl/ LinkedIn - https://www.linkedin.com/company/aging/ Reddit - https://www.reddit.com/user/AgingUS/ Pinterest - https://www.pinterest.com/AgingUS/ YouTube - https://www.youtube.com/@Aging-US Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Our guest today is Dr. Julie Chen, the Chief Medical Officer at Radence.   She previously served as Chief Medical Officer at companies such as Human Longevity and Vitagene. Her research, at the FDA, NIH, National Cancer Institute, USC, and Mount Sinai, has shaped scientific advancement in precision medicine. As a fellowship-trained integrative internal medicine physician, she developed numerous corporate wellness programs in Silicon Valley focusing on whole-systems approach to healthcare. Dr. Chen is a frequent medical expert on major media outlets, including ABC, NBC, FOX, and MSN, and she has been featured in national magazines and podcasts. In 2023, she was named one of the Top 25 Women Leaders in Biotechnology by Healthcare Technology Report for her leadership in health tech development. Dr. Chen is a member of the Buck Institute's President's Circle, dedicated to advancing research in aging and longevity.   Website and social media: www.radence.com https://www.linkedin.com/in/julie-chen-md-89035b14/ https://www.linkedin.com/company/radencehealth/posts/?feedView=all https://www.instagram.com/radencehealth/   This episode would be a rare opportunity to hear from one of medicine's most forward-looking voices on how personalized science, emerging technologies, and a proactive mindset are reshaping health span.   LEARN MORE ABOUT RADENCE: https://radence.com/insights-lab/redesigning-medicine-from-the-inside-out/

BUFFALO, NY — November 18, 2025 — A new #research paper was #published in Volume 17, Issue 10 of Aging-US on October 3, 2025, titled “Growth hormone excess drives liver aging via increased glycation stress.” In this study, led by first author Parminder Singh alongside with corresponding authors Pankaj Kapahi from the Buck Institute for Research on Aging and Andrzej Bartke from Southern Illinois University School of Medicine, researchers investigated how elevated growth hormone (GH) levels contribute to liver aging and dysfunction. They found that excess GH disrupts liver metabolism in ways that resemble aging-related liver damage. The study suggests that managing glycation stress may help prevent or treat liver diseases linked to abnormal hormone levels. Excess GH is known to cause different disorders, but its long-term impact on internal organs like the liver has remained unclear. To address this, researchers used a mouse model engineered to overproduce bovine GH and examined how chronic hormone exposure affects liver function over time. “Pathological conditions such as acromegaly or pituitary tumors result in elevated circulating GH levels, which have been implicated in a spectrum of metabolic disorders, potentially by regulating liver metabolism.” The team found that young mice with GH overexpression showed molecular and cellular patterns similar to those in naturally aged livers. In both groups, genes involved in metabolism were suppressed, while those linked to immune and inflammatory responses were activated. On one hand, the metabolic changes were associated with the buildup of advanced glycation end products, harmful compounds formed when sugars attach to proteins or fats without proper regulation. On the other hand, the immune and inflammatory changes reflected a process known as “inflammaging,” a form of chronic, low-grade inflammation commonly associated with aging. By revealing the overlap between hormone-driven and age-related liver dysfunction, the study provides new insight into how GH may accelerate aging processes. Importantly, the team showed that reducing glycation stress can reverse many of these negative effects. Mice treated with a compound that lowers glycation levels demonstrated improved liver health, reduced insulin resistance, and enhanced physical function. This intervention also corrected several abnormal genetic patterns caused by excess GH. The findings point to a potential therapeutic strategy for liver diseases associated with aging and hormonal imbalances. Overall, this research identifies glycation and its byproducts as key contributors to liver damage caused by excess GH. It suggests that targeting glycation could offer broad therapeutic benefits, not only for hormone-related conditions but also for supporting liver health during aging. DOI - https://doi.org/10.18632/aging.206327 Corresponding authors - Andrzej Bartke - abartke@siumed.edu and Pankaj Kapahi - pkapahi@buckinstitute.org Abstract video - https://www.youtube.com/watch?v=6v8xi5muLwA Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206327 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, growth hormone, glycation stress, Gly-Low To learn more about the journal, visit https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@Aging-US LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Just 4 simple lifestyle measures deliver 9 additional years of disease-free healthspan; Study underscores protein's role in staving off cancer, heart disease, and death; CoQ10 scores vs. neurodegeneration; Urolithin A (Mitopure®️) found to support athletic performance, immune function; Why you should ignore some influencers' advice to avoid fish oil. 

Text us a comment or question!What if the key to feeling younger, stronger, and more vibrant wasn't hidden in some futuristic lab - but inside your own body? In this week's episode, Kevin sits down with Dr. Dan Pardi, Chief Health Officer at Qualia Life Sciences and one of today's leading experts on behavior change, performance, sleep, and longevity science. Together they explore how stem cells - the body's natural repair system affect the way we age, recover, and regenerate. You'll discover why “health span” matters more than lifespan, how your lifestyle choices influence stem-cell function, and what you can do right now to support regeneration from the inside out. What You'll Learn:What stem cells actually are—and why they're central to aging and repairThe difference between lifespan and health span, and why the latter matters mostHow poor sleep, stress, and diet accelerate cellular agingThe behavior-change framework Dr. Pardi created to help people adopt lasting healthy habitsWhy we become more sensitive to both healthy and unhealthy choices as we ageThe fascinating link between performance, recovery, and longevityThe future of regenerative medicine - and what's available right now About Dr. Dan PardiDr. Pardi holds a PhD in Cognitive Neuroscience from Leiden University and Stanford, and a Master's in Exercise Physiology from Florida State.He's the former founder of humanOS.me, host of humanOS Radio, and has worked with organizations like Restore Hyper Wellness and the Buck Institute for Research on Aging.At Qualia Life Sciences, he leads research and protocol design for health-span optimization and peak human performance. ⚙️ Resources & Links

What if the real key to exploding your business isn't just innovation—but mastering the art of pivoting through change?   In this episode of Sharkpreneur, Seth Greene interviews Blair LaCorte, CEO at LaCorte Ventures. Blair is a leader who has guided multiple companies from startup to IPO and through major industry disruptions. Blair's career includes C-level roles at ExoJet Vista, TPG, Autodesk, Sun Microsystems, and the world's largest live entertainment production company. He's currently training as an astronaut for Virgin Galactic, serves as Vice Chairman of the Buck Institute for Research on Aging, and has collaborated with icons like Richard Branson, Elon Musk, and Bill Clinton. In this candid conversation, Blair shares how to recognize when to pivot versus double down, why change is the ultimate business opportunity, and how to build lasting connections that fuel personal and professional growth.   Key Takeaways: → The two essential skills every entrepreneur needs: fact-finding and quick-start decision-making. → How to tell if you're pivoting too much—or not enough. → Why change should be viewed as a profit opportunity, not a threat. → The biggest mistakes leaders make when reacting to disruption—and how to avoid them. → Why restructuring and scaling have more in common than most think.   Blair LaCorte is a dynamic business executive with a diverse career spanning entertainment, aviation, AI, technology, aerospace, consulting, investing, and military logistics. Raised by entrepreneurs, he has held CEO and C-level roles at major companies like PRG, XOJET/Vista, TPG, Autodesk, and Sun Microsystems/Oracle. Blair has helped lead multiple startups to successful IPOs, including AEye Technologies and VerticalNet. Currently, he is an astronaut-in-training for Virgin Galactic and serves as Vice Chairman of the Buck Institute, a leader in longevity research. He also co-founded and facilitates a Mastermind group of 40 global CEOs. Known for his engaging leadership and strategic vision, Blair has served on nonprofit boards alongside luminaries like Steve Kerr, Phil Jackson, Richard Branson, Elon Musk, and Bill Clinton.   Connect With Blair LaCorte: Website: https://mastermindinnovate.com/ LinkedIn: https://www.linkedin.com/in/blair-lacorte-68084/ Learn more about your ad choices. Visit megaphone.fm/adchoices

What if the real key to exploding your business isn't just innovation—but mastering the art of pivoting through change?   In this episode of Sharkpreneur, Seth Greene interviews Blair LaCorte, CEO at LaCorte Ventures. Blair is a leader who has guided multiple companies from startup to IPO and through major industry disruptions. Blair's career includes C-level roles at ExoJet Vista, TPG, Autodesk, Sun Microsystems, and the world's largest live entertainment production company. He's currently training as an astronaut for Virgin Galactic, serves as Vice Chairman of the Buck Institute for Research on Aging, and has collaborated with icons like Richard Branson, Elon Musk, and Bill Clinton. In this candid conversation, Blair shares how to recognize when to pivot versus double down, why change is the ultimate business opportunity, and how to build lasting connections that fuel personal and professional growth.   Key Takeaways: → The two essential skills every entrepreneur needs: fact-finding and quick-start decision-making. → How to tell if you're pivoting too much—or not enough. → Why change should be viewed as a profit opportunity, not a threat. → The biggest mistakes leaders make when reacting to disruption—and how to avoid them. → Why restructuring and scaling have more in common than most think.   Blair LaCorte is a dynamic business executive with a diverse career spanning entertainment, aviation, AI, technology, aerospace, consulting, investing, and military logistics. Raised by entrepreneurs, he has held CEO and C-level roles at major companies like PRG, XOJET/Vista, TPG, Autodesk, and Sun Microsystems/Oracle. Blair has helped lead multiple startups to successful IPOs, including AEye Technologies and VerticalNet. Currently, he is an astronaut-in-training for Virgin Galactic and serves as Vice Chairman of the Buck Institute, a leader in longevity research. He also co-founded and facilitates a Mastermind group of 40 global CEOs. Known for his engaging leadership and strategic vision, Blair has served on nonprofit boards alongside luminaries like Steve Kerr, Phil Jackson, Richard Branson, Elon Musk, and Bill Clinton.   Connect With Blair LaCorte: Website: https://mastermindinnovate.com/ LinkedIn: https://www.linkedin.com/in/blair-lacorte-68084/ Learn more about your ad choices. Visit megaphone.fm/adchoices

I've always been fascinated by the idea of biological age, how “old” your body really is versus what your passport says. When I first heard about DNA methylation tests that claim to measure that, I was hooked. Could we really peek into our own cellular aging?In this episode, I am joined by Dr. David Furman, a leading scientist at the Buck Institute for Research on Aging and the Director of the Stanford 1000 Immunomes Project. Dr. Furman shares his extensive knowledge on biological age and breaks down the latest technologies in aging science. With decades of expertise, he explains why current biological age tests, especially epigenetic clocks, aren't as reliable as they may seem, and what advancements are on the horizon.He explains why inflammation is at the center of age-related diseases and how targeting it could improve our health span, thus helping us not just live longer, but better.We also touch on some fascinating new technologies, including microgravity-based aging tests, which simulate the effects of aging on cells, revealing how specific organs may age differently.Plus, we get a glimpse into a smartphone app that can measure inflammation with just a selfie!Want to learn more about the future of aging and how you can take control of your biological age? Tune in now to hear from one of the leading experts in the field!Key TakeawaysIntroduction (00:00)Epigenetic tests and their limitations (01:04)Technical variability and alternative tests (02:28)Inflammation and aging (05:07)Trustworthiness and commercial interests (07:53)Challenges in biological age testing (12:52)Democratizing aging tests (15:41)Advanced aging tests (17:17)Final thoughts and future directions (22:04)Additional Resources:✨ Learn more about how to live a long and pain-free life: https://joykongmd.com/ ✨ Follow me on Facebook: https://www.facebook.com/stemcelldrjoy/ ✨ Follow me on Instagram: https://www.instagram.com/dr_joy_kong/ —Dr. Joy Kong is a regenerative medicine and anti-aging expert. Her podcast is part of her mission to reduce suffering and elevate happiness. Join us every week for the latest holistic health insights that will help you live a long and pain-free life.

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Ever heard of a medical procedure that's been called an “oil change for your blood”?In this episode, I sit down with Dr. Brad Younggren to explore Therapeutic Plasma Exchange (TPE), a cutting-edge intervention that just might help extend healthspan, reduce biological age, and even clear hidden toxins like microplastics.We discuss the fascinating science behind TPE, from the famous parabiosis experiments in rodents to human trial data from Circulate and the Buck Institute. Dr. Younggren walks us through what really happens during TPE, which biomarkers shift the most, and who might benefit the most.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Chapters:00:00:00 — “Oil change for blood”00:01:05 — How TPE works (centrifuge)00:05:10 — Foundational science/parabiosis00:12:07 — Trial design & sham control00:22:39 — Headline result: “-2.6 years”00:34:01 — Compartment theory explained00:46:31 — Moving TPE to clinics00:48:03 — Long-COVID anecdote00:54:34 — Microplastics discussion01:06:38 — Cost & access overviewDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

BUFFALO, NY — September 23, 2025 — A new #research paper was #published in Volume 17, Issue 8 of Aging-US on August 7, 2025, titled “Senescent cell heterogeneity and responses to senolytic treatment are related to cell cycle status during senescence induction.” This study, led by first authors Francesco Neri and Shuyuan Zheng, together with corresponding authors Denis Wirtz, Pei-Hsun Wu, and Birgit Schilling from the Buck Institute for Research on Aging, the USC Leonard Davis School of Gerontology, and Johns Hopkins University, reveals that not all aging cells behave the same. The researchers identified key differences between senescent cell subtypes that may influence how well they respond to senolytic drugs. These findings could help guide the development of more effective therapies for age-related diseases. Senescent cells are aged or damaged cells that stop dividing and accumulate in tissues over time. While they play a role in wound healing and protecting against cancer early in life, they can drive chronic inflammation and tissue decline with age. Researchers are exploring ways to selectively remove these cells using senolytic drugs. However, the large variety of senescent cell types has made it difficult to design treatments that work for all of them. This study aimed to better understand the functional differences among senescent cell subpopulations. Using high-resolution imaging, the team analyzed thousands of human endothelial and fibroblast cells growing in the lab. They observed that cells that exited the cell cycle (stopped dividing) in a later phase showed stronger signs of senescence and were more sensitive to senolytic treatment. These cells also produced more IL-6, a molecule associated with inflammation. The findings suggest that DNA content, which varies depending on the cell cycle phase, plays an important role in how aging cells function and how they respond to drugs. “We found that G2-arrested senescent cells feature higher senescence marker expression than G1-arrested senescent cells.” This is the first clear evidence that senescent cells do not all respond equally to treatment. The results suggest that future senolytic therapies could be more successful if they are designed to target specific subtypes of senescent cells, especially those with greater inflammatory potential. While this research was conducted in laboratory cell cultures, it provides a foundation for studying how these findings apply to living tissues. Future work will examine whether similar patterns occur in the body and how this knowledge could lead to more precise and effective treatments for age-related conditions. Understanding the diversity of aging cells is key to developing therapies that are both safer and more targeted. DOI - https://doi.org/10.18632/aging.206299 Corresponding authors - Denis Wirtz — wirtz@jhu.edu, Pei-Hsun Wu — pwu@jhu.edu, and Birgit Schilling — bschilling@buckinstitute.org Abstract video - https://www.youtube.com/watch?v=x8bhKEFLzqA Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206299 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, cellular senescence, imaging, heterogeneity, senolytics, cell cycle To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Blair LaCorte is the Vice Chair of the Board of Directors at the Buck Institute for Research on Aging—the world's first biomedical research institution dedicated solely to understanding aging and age-related diseases, and the largest independent scientific institute in the Bay Area. A seasoned leader and strategist, Blair has a track record of transforming companies across five industries, leveraging his expertise in change management to drive operational alignment, scale, and market leadership. Most recently, he led AEye's $1.5B IPO, advancing the company's mission to enable safe, reliable vehicle autonomy. Prior to that, Blair served as Global President of PRG, the world's largest live event technology and services company; CEO of XOJET, one of the fastest-growing aviation companies in history; and Senior Advisor and Operating Partner at TPG, a leading private equity firm managing over $97 billion in global investments. His earlier career includes executive roles at technology innovators such as VerticalNet, Savi Technologies, Autodesk, and Sun Microsystems. Blair is an active board member and advisor to organizations spanning science, business, and education, including the Positive Coaching Alliance, the Kairos Society, the Graduate Business Foundation, and alma maters Dartmouth College and the University of Maine. His leadership has been recognized by Fast Company, Ad Age, NASA, and the ITAS “100 Most Influential Leaders in Transportation” list. His insights have been featured in Forbes, Fortune, The Wall Street Journal, and on major networks including ABC, Bloomberg, CNN, and CNBC. Holding multiple patents across hardware, software, communications, security, and defense, Blair is also an astronaut-in-training and is scheduled to fly with Virgin Galactic. Outside of his professional pursuits, he is a dedicated father to three sons and the owner of a slightly anxious Weimaraner named Bella. Work With Us: Arétē by RAPID Health Optimization Links: Blair LaCorte on LinkedIn Anders Varner on Instagram Doug Larson on Instagram Coach Travis Mash on Instagram  

Inflammation is the body's natural way of healing, but when it becomes chronic and hidden, it quietly drives many of today's most common health problems—heart disease, diabetes, dementia, cancer, autoimmune conditions, and more. Unlike the redness and swelling from a cut or sprain, this “silent inflammation” often goes unnoticed while slowly damaging tissues and speeding up aging. Modern life fuels the fire: processed foods, food additives, pollution, plastics, chronic stress, too much sitting, and poor sleep. The good news is inflammation can be calmed by simple daily choices—eating colorful whole foods like berries, leafy greens, beans, nuts, seeds, and omega-3 rich fish; adding herbs and spices like turmeric and cumin; moving regularly; practicing relaxation; and repairing gut health. Even small shifts, like climbing stairs, eating within a shorter window, or reducing sugar, can make a big difference. By lowering inflammation, the body finds balance again, opening the door to more energy, resilience, and healthy aging. In this episode, I discuss, along with Dr. Shilpa Ravella and Dr. David Furman, why it's important to be aware of systemic inflammation and how to address it. Dr. Ravella is a gastroenterologist and Assistant Professor of Medicine at Columbia University Medical Center. She is the author of A Silent Fire: The Story of Inflammation, Diet & Disease, which investigates inflammation—the hidden force at the heart of modern disease. Her writing has appeared in The Atlantic, New York Magazine, The Wall Street Journal, TIME, Slate, Discover, and USA Today, among other publications.  Dr. David Furman is Associate Professor and Director of the Bioinformatics Core at the Buck Institute for Research on Aging, as well as the Director of the Stanford 1000 Immunomes Project. He obtained his doctoral degree in immunology from the School of Medicine, University of Buenos Aires, Argentina, for his work on cancer immune-surveillance. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans. He has published nearly thirty scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others.  This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN to save 15%. Full-length episodes can be found here:What Causes Inflammation And How Can You Treat It? The Silent Killer: Inflammation And Chronic Disease How Silent Inflammation Accelerates Aging

BUFFALO, NY — September 4, 2025 — A new #research perspective was #published in Volume 17, Issue 8 of Aging (Aging-US) on August 16, 2025, titled “Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis.” In this research perspective, Alex Zhavoronkov, Dominika Wilczok, Feng Ren, and Fedor Galkin, from Insilico Medicine, Buck Institute for Research on Aging, and Duke University, propose a new method to evaluate age-related diseases based on how closely they align with the biological processes of aging. Their analysis shows that idiopathic pulmonary fibrosis (IPF), a progressive lung condition, is one of the diseases most strongly associated with aging. This makes IPF a promising model for testing new anti-aging therapies with the potential to treat multiple age-related conditions. “This perspective explores how aging-related diseases (ARDs) can serve as experimental platforms for discovering new geroprotective interventions.” While many age-related diseases are used as models for aging research, not all accurately reflect the biology of aging. To address this, the authors developed a scoring system that measures how closely a disease is connected to the key hallmarks of aging, such as inflammation, genetic instability, and impaired cellular repair. Using this system, they evaluated 13 common age-related diseases and found that IPF had a particularly high overlap with aging biology. IPF is a chronic disease that causes scarring in the lungs and a rapid decline in lung function. In contrast to the gradual loss of function seen in normal aging, IPF progresses more than five times faster. The authors highlight that IPF shares nearly all of the biological features associated with aging. These similarities make IPF a strong candidate for studying aging and testing therapies that target its underlying causes. The authors also discuss different therapies currently being developed for IPF that are also designed to address aging itself. These include drugs that clear senescent cells, activate telomerase to maintain chromosome health, or repair damaged signaling between cells. Some of these treatments, such as senolytic combinations and AI-discovered compounds like rentosertib, are already showing early promise in preclinical or clinical trials. In addition, the authors point out that IPF's fast progression and clearly measurable outcomes offer an advantage for clinical testing. If a therapy proves effective in IPF, it may also be useful for other conditions that share similar aging-related mechanisms, including diabetes, arthritis, and heart disease. This approach could accelerate drug development and reduce costs by focusing on therapies that target shared biological pathways. Overall, this perspective supports a shift in pharmaceutical research toward treating aging as an underlying cause of many chronic diseases. By positioning IPF as a model for aging-related drug development, the authors propose a strategic pathway for testing and expanding anti-aging therapies across a wide range of health conditions. DOI - https://doi.org/10.18632/aging.206301 Corresponding author - Alex Zhavoronkov – alex@insilico.com Video short - https://www.youtube.com/watch?v=p5ur7itzvSI Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging. Eric discusses the science behind therapeutic plasma exchange (TPE) and its potential to slow biological aging in humans. The conversation explores findings from a recent clinical trial, including measurable age reversal using epigenetic clocks.Eric explains how removing and replacing plasma can dilute pro-aging factors in the blood, a concept inspired by earlier animal studies on parabiosis. He also describes why rigorous, placebo-controlled human trials are crucial for validating longevity interventions and distinguishing the field from hype-driven wellness trends.The episode also highlights how omics data, such as metabolomics and proteomics, are shaping a new era of precision aging research. Eric emphasizes the value of lifestyle interventions as a foundation and sees future opportunities in combining TPE with personalized strategies to extend healthspan.  Guest-at-a-Glance

Did you know that your ovaries are so much more than just for making babies? They don't just die after menopause and today we are going to learn so much more about their function, HRT and so much more with California OB-GYN Dr. Lizellen LaFollette We cover: How she treated her patients after the WHI came down with the headlines that estrogen causes cancer…which btw, it doesn't What her vision is for the future of menopause research and treatments for women What she learned at the Buck Institute of Aging through her research on ovarian aging And so much more Dr. Lizellen LaFollette is a board-certified OB-GYN with more than three decades of experience caring for women in the Bay Area in obstetrics, gynecology, menopause and aesthetics. Based in Greenbrae, California, she is known for her leadership in minimally invasive gynecologic surgery. In addition to her clinical practice, Dr. LaFollette has been an investigator and advisor for multiple studies in women's health, including research on preterm labor risk, inflammation biomarkers, and reproductive longevity through her work with the Buck Institute's Reproductive Longevity Consortium.  She is so often voted “Top Doctor” by her local journals. And is committed to evidence-based, patient-centered care. Her areas of focus include menopause management, reproductive aging, and reducing unnecessary cesarean sections, while continuing to integrate the latest innovations to improve women's health across the lifespan. You're going to love this conversation CONTACT Email: office@drlafollette.com Instagram: https://www.instagram.com/drlafollette/ Website: https://drlafollette.com   Give thanks to our sponsors: Try Vitali skincare. 20% off with code ZORA here. Get Primeadine spermidine by Oxford Healthspan. 15% discount with code ZORA ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Get Mitopure Urolithin A by Timeline. 20% discount with code ZORA at https://timeline.com/zora Try Suji to improve muscle 10% off with code ZORA at TrySuji.com https://trysuji.com Try OneSkin skincare with code ZORA for 15% off https://oneskin.pxf.io/c/3974954/2885171/31050 Join ⁠⁠⁠Biohacking Menopause⁠⁠⁠ before October 1, 2025 to win a Flexbeam Red Light Therapy Device. Or save 10% with code ZORA at recharge.health   Join the Hack My Age community on: YouTube: https://youtube.com/@hackmyage Facebook Page: ⁠⁠⁠⁠⁠@⁠Hack My Age⁠       Facebook Group: ⁠⁠⁠⁠⁠⁠@⁠Biohacking Menopause⁠⁠⁠⁠⁠⁠ ⁠  Private Women's Only Support Group: https://hackmyage.com/biohacking-menopause-membership/ Instagram: ⁠⁠⁠⁠⁠@⁠HackMyAge⁠    Website: ⁠⁠⁠⁠⁠⁠HackMyAge.com⁠   

In the opening pages of my guest's book, she recounts a colleague's bumpy plane ride that provided the insight for the title of the book, Taming the Turbulence in Educational Leadership: “We are facing turmoil in education, and the job of good leaders is to 'tame the turbulence'...educators have been caught in this turbulence; it permeates our profession and we haven't been able to get above it. As a result, it is the role of leaders to help teachers see how even small, simple shifts can change a child's experience of school.”Rooted in real-world stories, Taming the Turbulence offers solidarity and actionable strategies to education leaders committed to centering the needs of all learners in increasingly polarized societies.And the author, Jennifer D. Klein, is an experienced educator and advocate for student-centered, experiential learning as a catalyst for positive social change. With two-decades of classroom teaching across a number of diverse international settings, as a teacher in Costa Rica and a school leader in Colombia, she now focuses on inspiring and training educators worldwide, working with groups like What School Could Be, The Institution for International Education, and The Buck Institute. Her previous books include The Global Education Guidebook: Humanizing K–12 Classrooms Worldwide Through Equitable Partnerships and The Landscape Model of Learning: Designing Student-Centered Experiences for Cognitive and Cultural Inclusion, coauthored with Kapono Ciotti, who we spoke with about that work back in episode 159.You can connect with Jennifer at principledlearning.orgTaming the Turbulence in Educational Leadership from Corwin

Could saying no actually be your best longevity strategy? Blair LaCorte reveals why avoiding over-optimization and focusing on system biology, compassion, and purpose instead leads to authentic biosynergy and lasting vitality. Meet our guest Blair LaCorte is a dynamic business executive whose career spans entertainment, aviation, AI, technology, aerospace, consulting, investing & military logistics. He has held CEO & C-level roles at leading companies like PRG, XOJET/Vista, TPG, Autodesk & Oracle, while also taking startups such as AEye Technologies & VerticalNet to IPO. Currently an astronaut-in-training with Virgin Galactic & Vice Chairman of the Buck Institute, Blair continues to drive innovation, growth & global impact. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Tech is for control, not a cure all Forgetting biology leads to problems, not progress Over optimizing health with gadgets causes new problems Step back & look at the whole picture Scientific knowledge & personal belief both affect your biology & well being more than most realize Staying healthy is better than only reacting to sickness Small daily choices matter more than silver bullets Focus on what works for you Test, observe, & stick with what fits your life & makes you feel good Relationships lower stress & boost your immune system Loneliness is a major health risk at any age Some stress helps growth Chronic unbroken stress harms your body Find ways to activate & calm yourself Knowing health tips isn't enough Build habits you enjoy, ideally with friends or community support, for lasting results No two people are alike Track your own changes & work out routines & diets that fit you specifically Modern testing makes it easier to spot issues early Keep personal health records to track your biomarkers over time Episode highlights 04:19 Why Technology Alone Won't Save Your Health 21:17 The Real Framework for Habit Change That Works 28:50 What Truly Multiplies Healthspan Results 36:44 Practical Ways to Strengthen Connection & Reduce Stress 46:28 How to Personalize Health in a Complex World Links Watch it on YouTube: https://youtu.be/U2QuhPEugq4 Full episode show notes: outliyr.com/223 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Eric Verdin is a physician-scientist and the CEO of the Buck Institute for Research on Aging whose career has centered on understanding how epigenetics, metabolism, and the immune system influence the aging process. In this episode, Eric traces his scientific journey from studying viruses and histone deacetylases (HDACs) to leading aging research at the Buck Institute, offering insights into how aging impairs immune and nervous system function—including thymic shrinkage, chronic inflammation, and reduced vaccine response—and how these changes impact lifespan. He explores the metabolic underpinnings of aging, such as oxidative stress and insulin and IGF-1 signaling, and he discusses practical tools like zone 2 cardio, ketogenic diets, and GLP-1 drugs. The conversation also covers declining NAD levels with age, the roles of NAD-consuming enzymes such as sirtuins and CD38, and what current NAD-boosting strategies (like NMN, NR, and IV NAD) can and can't accomplish. Eric weighs in on promising longevity interventions including rapamycin, growth hormone for thymic regeneration, and anti-inflammatory therapies, while also examining the promise and limitations of current biological age tests and the potential of combining epigenetic, proteomic, and organ-specific metrics with wearables to guide personalized longevity care. We discuss: Eric's scientific journey from virology to the field of geroscience [2:45]; How dysfunction in the immune system and central nervous system can drive aging throughout the body [5:00]; The role of metabolism and oxidative stress in aging, and why antioxidant strategies have failed to deliver clear benefits [8:45]; Other aspects of metabolism linked to aging: mitochondrial efficiency, fuel utilization, and glucose-modulating drugs [16:30]; How inefficient glucose metabolism drives insulin, IGF-1 signaling, and accelerates aging [21:45]; The metabolic effects of GLP-1 agonists, and the need to move beyond crude metrics like BMI in favor of more precise assessments of metabolic health [27:00]; The case for immune health as a “fifth horseman” [36:00]; How the innate and adaptive immune systems work together to build immune memory [39:45]; Why vaccines lose effectiveness with age: shrinking of the thymus gland and diminished T-cell diversity [44:15]; Exploring growth hormone, thymic regeneration, and the role of exercise in slowing immune aging [48:45]; The challenges of identifying reliable biomarkers for immune function, and the potential of rapamycin analogs to enhance vaccine response in older adults [57:45]; How rapamycin's effects on the immune system vary dramatically by dosage and frequency [1:03:30]; The limitations of mouse models in aging research and the need for cautious interpretation of rapamycin's benefits in humans [1:08:15]; NAD, sirtuins, and aging: scientific promise amid commercial hype [1:15:45]; How CD38 drives age-related NAD decline, influences immune function, and may impact longevity [1:23:45]; How NMN and NR supplementation interact with CD38 and NAD metabolism, and potential risks like homocysteine elevation and one-carbon cycle depletion [1:31:00]; Intravenous NAD: limited evidence and serious risks [1:37:00]; Interleukin-11 (IL-11) as a new target in immune aging, the dual role of chronic inflammation in aging, and the need for better biomarkers to guide interventions [1:43:00]; Biological aging clocks: types of clocks, promise, major limitations, and future outlook [1:48:30]; The potential of proteomics-based aging clocks for detecting organ-specific decline and frailty [2:00:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Brian Kennedy is a renowned biologist, leader in aging research, and director of the Center for Healthy Longevity at the National University of Singapore. In this episode, Brian shares insights from ongoing human aging studies, including clinical trials of rapamycin and how dosing strategies, timing, and exercise may influence outcomes. He presents two key models of aging—one as a linear accumulation of biological decline and the other as an exponential rise in mortality risk—and explains why traditional models of aging fall short. He also explains why most current aging biomarkers lack clinical utility and describes how his team is working to develop a more actionable biological clock. Additional topics include the potential of compounds like alpha-ketoglutarate, urolithin A, and NAD boosters, along with how lifestyle interventions—such as VO2 max training, strength building, and the use of GLP-1 and SGLT2 drugs—may contribute to longer, healthier lives. We discuss: Brian's journey from the Buck Institute to Singapore, and the global evolution of aging research [2:45]; Rethinking the biology of aging: why models like the hallmarks of aging fall short [9:45]; How inflammation and mTOR signaling may play a central, causal role in aging [14:15]; The biological role of mTOR in aging, and the potential of rapamycin to slow aging and enhance immune resilience [17:30]; Aging as a linear decline in resilience overlaid with non-linear health fluctuations [22:30]; Speculating on the future of longevity: slowing biological aging through noise reduction and reprogramming [33:30]; Evaluating the role of the epigenome in aging, and the limits of methylation clocks [39:00]; Balancing the quest for immortality with the urgent need to improve late-life healthspan [43:00]; Comparing the big 4 chronic diseases: which are the most inevitable and modifiable? [47:15]; Exploring potential benefits of rapamycin: how Brian is testing this and other interventions in humans [51:45]; Testing alpha-ketoglutarate (AKG) for healthspan benefits in aging [1:01:45]; Exploring urolithin A's potential to enhance mitochondrial health, reduce frailty, and slow aging [1:05:30]; The potential of sublingual NAD for longevity, and the combination of NAD and AKG for metabolic and exercise enhancement [1:09:00]; Other interventions that may promote longevity: spermidine, 17

BIO: Blair LaCorte is a dynamic executive with experience across entertainment, aviation, AI, aerospace, consulting, and more.STORY: Blair shares three catastrophic investment failures and the life-altering lessons that rewired his approach to wealth.LEARNING: Chase knowledge, not hype, and don't let greed hijack logic. Invest with friends only if you're willing to lose both. “The worst investment that you can make is to put your time into something that you don't enjoy or that you know is not going to work out.”Blair LaCorte Guest profileBlair LaCorte is a dynamic executive with experience across entertainment, aviation, AI, aerospace, consulting, and more. He has held CEO roles at companies such as PRG, XOJET, and Autodesk, and led startups to successful IPOs. Currently, he's training as an astronaut for Virgin Galactic and is Vice Chairman at the Buck Institute.Worst investment everFresh out of college at 22, Blair met a smooth-talking investor who flaunted his “lifetime monthly checks” from an oil well. Blinded by dollar signs and zero industry knowledge, he poured his savings into a single well.Blair ignored basic due diligence, diversification, and warnings about low-quality reserves. It was all about greed. He had seen someone make money where they got paid every month for the rest of their life, as long as the well lasted.The greed kept him in and kept him investing in the well. At the end of the day, the oil was of below-average quality and was not as much as they thought it would be. Blair's ignorance caused him a 100% loss. The well underperformed, and his greed trapped him in a sinking ship. Blair even commissioned a plaque to memorialize his shame—a daily reminder that “easy money” is a predator in disguise.Burning $200k and a friendshipAfter Blair's first IPO success in 1999, his roommate pitched him on Coffee.com—a visionary play on single-origin beans (decades before it became trendy). Blair invested early, then panicked as losses mounted. When the roommate begged for more capital, he refused because he did not think it would succeed, but guilt kept him from cutting ties.After a while, the startup imploded. Worse? Blair's friend never spoke to him again. He learned the hard truth from this unwise investment: mixing money with friendship is financial suicide.The $59.50 ego taxAt the peak of the dot-com boom, Blair had just scored a top-tier IPO. His broker urgently called and advised him to sell immediately at $59.50 as he believed the boom would not last. But pride convinced him that the broker was just chasing commissions.Blair held stubbornly as the stock bled out to $2. He lost $570,000 in vaporized gains. Blair's ego had bet against reality, and reality won.Lessons learnedChase knowledge, not hype, and don't let greed hijack logic. If you don't understand how the money is made, you're the exit strategy for someone else.Friends + money = atomic risk. Invest with friends only if you're willing to lose both on the same day.Pride is the silent portfolio killer. The market doesn't care about your ego, and exit signals don't negotiate.Your time is your ultimate currency. Grinding your years into a dying venture to ‘prove a point' is the costliest investment of all.Andrew's takeawaysMacro trumps micro. Brilliant ideas fail if they're too early or too late. Always ask: “Is the world ready for this?”Preserve capital like your life depends on it. A young you can risk time; an older you must protect...

In this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain. They discuss the brain's heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges posed by drug delivery across the blood-brain barrier. The conversation also delves into innovative strategies to support mitochondrial health, including the potential of lysosomal rejuvenators and senolytics, as well as the importance of identifying early biomarkers for neurodegenerative conditions. Dr. Andersen also underscores the critical role of lifestyle interventions—especially exercise—in maintaining brain health. Learn more about Dr. Julie Andersen and the Buck Institute: https://www.buckinstitute.org/lab/andersen-lab/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

******Support the channel******Patreon: https://www.patreon.com/thedissenterPayPal: paypal.me/thedissenterPayPal Subscription 1 Dollar: https://tinyurl.com/yb3acuuyPayPal Subscription 3 Dollars: https://tinyurl.com/ybn6bg9lPayPal Subscription 5 Dollars: https://tinyurl.com/ycmr9gpzPayPal Subscription 10 Dollars: https://tinyurl.com/y9r3fc9mPayPal Subscription 20 Dollars: https://tinyurl.com/y95uvkao ******Follow me on******Website: https://www.thedissenter.net/The Dissenter Goodreads list: https://shorturl.at/7BMoBFacebook: https://www.facebook.com/thedissenteryt/Twitter: https://x.com/TheDissenterYT This show is sponsored by Enlites, Learning & Development done differently. Check the website here: http://enlites.com/ Dr. Deena Emera is an evolutionary biologist, author, and teacher. She is a Senior Scientist and Writer-in-Residence in the Center for Reproductive Longevity and Equality at the Buck Institute, where she is drawing on her evolutionary background and expertise on female reproduction to investigate the evolution of menopause. She is the author of A Brief History of the Female Body: An Evolutionary Look at How and Why the Female Form Came to Be. In this episode, we focus on A Brief History of the Female Body. We start by discussing what a female is. We then go through traits like breasts, menstruation, the female orgasm, female love and sexual selection, pregnancy, motherhood and mother-offspring conflict, and menopause and the grandmother hypothesis.--A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: PER HELGE LARSEN, JERRY MULLER, BERNARDO SEIXAS, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, FILIP FORS CONNOLLY, ROBERT WINDHAGER, RUI INACIO, ZOOP, MARCO NEVES, COLIN HOLBROOK, PHIL KAVANAGH, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, FERGAL CUSSEN, HAL HERZOG, NUNO MACHADO, JONATHAN LEIBRANT, JOÃO LINHARES, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, ROMAIN ROCH, DIEGO LONDOÑO CORREA, YANICK PUNTER, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, NELLEKE BAK, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, HEDIN BRØNNER, DOUGLAS FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, SCOTT, ZACHARY FISH, TIM DUFFY, SUNNY SMITH, JON WISMAN, WILLIAM BUCKNER, PAUL-GEORGE ARNAUD, LUKE GLOWACKI, GEORGIOS THEOPHANOUS, CHRIS WILLIAMSON, PETER WOLOSZYN, DAVID WILLIAMS, DIOGO COSTA, ALEX CHAU, AMAURI MARTÍNEZ, CORALIE CHEVALLIER, BANGALORE ATHEISTS, LARRY D. LEE JR., OLD HERRINGBONE, MICHAEL BAILEY, DAN SPERBER, ROBERT GRESSIS, JEFF MCMAHAN, JAKE ZUEHL, BARNABAS RADICS, MARK CAMPBELL, TOMAS DAUBNER, LUKE NISSEN, KIMBERLY JOHNSON, JESSICA NOWICKI, LINDA BRANDIN, VALENTIN STEINMANN, ALEXANDER HUBBARD, BR, JONAS HERTNER, URSULA GOODENOUGH, DAVID PINSOF, SEAN NELSON, MIKE LAVIGNE, JOS KNECHT, LUCY, MANVIR SINGH, PETRA WEIMANN, CAROLA FEEST, MAURO JÚNIOR, 航 豊川, TONY BARRETT, NIKOLAI VISHNEVSKY, STEVEN GANGESTAD, TED FARRIS, ROBINROSWELL, KEITH RICHARDSON, HUGO B., AND JAMES!A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, TOM VANEGDOM, BERNARD HUGUENEY, CURTIS DIXON, BENEDIKT MUELLER, THOMAS TRUMBLE, KATHRINE AND PATRICK TOBIN, JONCARLO MONTENEGRO, NICK GOLDEN, CHRISTINE GLASS, IGOR NIKIFOROVSKI, AND PER KRAULIS!AND TO MY EXECUTIVE PRODUCERS, MATTHEW LAVENDER, SERGIU CODREANU, ROSEY, AND GREGORY HASTINGS!

Did you know you can detect Alzheimer's risk in your 20s with a simple blood test? In this Habits and Hustle episode, I sit down with Dr. Dale Bredesen, the first scientist to successfully reverse Alzheimer's disease. We explore the three major causes of cognitive decline, why your brain fog might be pre-Alzheimer's, and the shocking truth about everyday toxins like sushi, hair dye, and microplastics. We also dive into the KetoFlex 12-3 protocol and why 45 million Americans are headed for Alzheimer's. From sleep apnea's brain damage to the surprising benefits of saunas and cold plunges, this episode transforms everything you thought you knew about brain health. Dr. Dale Bredesen is an internationally recognized expert in neurodegenerative diseases and creator of the ReCODE Protocol™. He earned his M.D. from Duke University, served as founding President and CEO of the Buck Institute, and is author of the New York Times bestseller The End of Alzheimer's. What We Discuss:  (01:00) - Reversing Alzheimer's (14:53) - Toxins and Brain Health (21:31) - Brain Health and Sleep Quality (36:01) - Toxins and Dietary Choices (41:16) - Optimizing Brain Health Through Lifestyle (50:55) - Reversing Inflammation and Brain Decline (58:23) - Toxins, Mitochondria, and Cognitive Health (01:19:40) - Differentiating Dementia From Alzheimer's (01:23:59) - Achieving Optimal Brain Health Through Diet (01:27:50) - Restoring Brain Energy With Ketones …and more! Thank you to our sponsors: Momentous: Shop this link and use code Jen for 20% off Therasage: Head over to therasage.com and use code Be Bold for 15% off  TruNiagen: Head over to truniagen.com and use code HUSTLE20 to get $20 off any purchase over $100. Magic Mind: Head over to www.magicmind.com/jen and use code Jen at checkout. Bio.me: Link to daily prebiotic fiber here, code Jennifer20 for 20% off.  David: Buy 4, get the 5th free at davidprotein.com/habitsandhustle.   Find more from Jen:  Website: https://www.jennifercohen.com/ Instagram: @therealjencohen   Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagement Find more from Dr. Dale Bredesen: Website: https://www.apollohealthco.com/dr-bredesen/  Instagram: https://www.instagram.com/apollohealthco/

Dr. Brianna Stubbs, director of Translational Science at the Buck Institute for Research on Aging, explores the science behind ketone metabolism and its benefits for women. Learn how ketones can support your fitness goals, regulate appetite, aid in recovery, and even contribute to healthy brain aging. This episode is full of actionable insights and valuable tips for incorporating ketones into your wellness routine.KETONE-IQ Get 30% off when you Subscribe & Save at https://ketone.com/STEPHANIEEpisode Overview (timestamps are approximate):(10:00) Optimizing Performance With Ketones(23:00) Ketones and Appetite Regulation(28:00) Ketones and Muscle Protection(36:00) Ketones, Exercise, and Muscle Metabolism(43:00) Strategic Use of Ketones for Performance(48:00) Ketones for Energy and Recovery(53:00) Ketones and Cellular Aging(1:04:00) Advancing Biomarkers for Healthy Aging(1:09:00) BONUS the “After-Party” with Dr. StephanieResources mentioned in this episode acn be found at https://drstephanieestima.com/podcasts/ep422We are grateful to our sponsors:LVLUP - Midlife hormonal changes can wreak havoc on your gut health. Ultimate GI Repair combines powerful gut-healing peptides with gut-nourishing naturals to soothe your changing digestion. Learn more at https://lvluphealth.com/DRSTEPHANIE and use code DRSTEPHANIE for 15% offONESKIN - Harness the power of peptides for fuller hair and glowing skin. Save 15% at https://oneskin.co/better with code BETTER.EQUIP COLLAGEN - Support bones, joints, gut, and skin with Equip Collagen. Get 20% off at https://equipfoods.com/better with code BETTER.LMNT - Rehydrate with the perfect mix of sodium, potassium, and magnesium. Get a free sample pack at https://drinklmnt.com/drestima.

Send us a textIn this episode of Causes or Cures, we explore insights into brain health and longevity with NYT bestselling author and neurologist Dr. Dale Bredesen.Dr. Bredesen explains why he believes cognitive decline is not an inevitable part of aging and outlines six biological processes he identifies as impacting brain aging. He also shares practical tools he recommends for assessing how well your mind is functioning. We discuss the alarming rise in early-onset dementia among people in their 30s and 40s and the potential causes behind this increase. Dr. Bredesen also talks about the links between COVID, sugar intake, and dementia risk. He offers science-based advice on diet, sleep, and lifestyle strategies that support an ageless brain.Additionally, Dr. Bredesen addresses how the for-profit healthcare system can hinder Alzheimer's management and shares his comprehensive ReCODE Protocol™, which he presents as a promising approach to preventing and potentially reversing cognitive decline, though it has sparked passionate discussions and differing opinions in the Alzheimer's and broader medical communities.About Dr. Dale Bredesen Dr. Bredesen is an internationally recognized expert in neurodegenerative diseases and the author of The Ageless Brain and The End of Alzheimer's Disease. He earned his M.D. from Duke University Medical Center, completed his neurology residency at UCSF, and was an NIH Postdoctoral Fellow in Nobel laureate Stanley Prusiner's laboratory. He has held faculty positions at UCSF, UCLA, and UC San Diego, and was founding President and CEO of the Buck Institute for Research on Aging. Dr. Bredesen's pioneering research has led to innovative treatments and the development of the ReCODE Protocol™, offering new hope in the fight against Alzheimer's disease.You can contact Dr. Eeks at bloomingwellness.com.Follow Eeks on Instagram here.Or Facebook here.Or X.On Youtube.Or TikTok.SUBSCRIBE to her monthly newsletter here.Support the show

What do aviation, AI, parenting, and longevity have in common? Blair LaCorte. In this fast-paced episode, Episode 243 of the Fit Father Project Podcast, he shares with Dr. Anthony Balduzzi the biggest lessons from his high-performance life — and how we can all build a stronger body, mind, and purpose. Together, they explore the powerful idea that safety — both physical and emotional — is the foundation for longevity, authentic living, and effective parenting. Blair shares how formative childhood experiences shaped his entrepreneurial spirit, why midlife transitions are deeply necessary, and how self-love is one of the highest acts of love for your children.Blair explains how your parasympathetic nervous system — the “rest and digest” network — underpins your mental, physical, and emotional well-being. He emphasizes the vital role of feeling safe, connected, and curious in both health and personal evolution. His advice? Move every hour, sleep according to your chronotype, get sunlight in your eyes first thing in the morning, and start each day with intention. From daily mantras to longevity science from the Buck Institute, Blair's practical wisdom is packed with insights.The conversation also dives into actionable tips for parents on creating resilient, curious, and emotionally stable kids — without overprotecting them. Blair's candid reflection on failure, identity, and the modern health landscape is both refreshing and empowering. Whether you're looking to optimize your body, reconnect with your purpose, or better guide your children in the AI age, this episode delivers.Key TakeawaysChildhood wiring shapes lifelong behaviorSelf-love is essential for effective parentingAuthenticity is the key to a regret-free lifeSafety regulates the parasympathetic nervous systemYour nervous system is the root of health spanFrequent movement trumps long workoutsMorning sunlight resets your biological clockDaily mantras shift your brain's focusSitting is the new smoking — get up hourlyConnection is the #1 longevity multiplierFood is the most important input for your healthKids need a safe place to fail and growRandom acts of kindness heal both giver and receiverLearn More about Blair LaCorte:Websites: https://ppemastermind.com/ https://www.mastermindinnovate.com/ LinkedIn: https://www.linkedin.com/in/blair-lacorte-68084/YouTube: https://www.youtube.com/channel/UCTSlr8fDtSu4Ev_hF6tyqDwBiographical Information on Blair LaCorte:Blair LaCorte is a dynamic business executive who after being raised by two entrepreneurs has taken a path less traveled, unless of course you were Forrest Gump! His career spans numerous industries such as entertainment, aviation, AI, technology, aerospace, consulting, investing and military logistics. Renowned for his insatiable curiosity, collaborative spirit, passionate oratorical skills and competitive drive, Blair consistently strives to make a positive contribution and impact in all his endeavors.For Credibility: Blair has held CEO or “C” level strategy or operating roles in companies such PRG (largest live entertainment production company), XOJET/Vista (largest private aviation company), TPG (one of largest PE firms), Autodesk (largest CAD SW company), and Sun Microsystems / Oracle...

What do aviation, AI, parenting, and longevity have in common? Blair LaCorte. In this fast-paced episode, Episode 153 of the Fit Mother Project Podcast, he shares with Dr. Anthony Balduzzi the biggest lessons from his high-performance life — and how we can all build a stronger body, mind, and purpose. Together, they explore the powerful idea that safety — both physical and emotional — is the foundation for longevity, authentic living, and effective parenting. Blair shares how formative childhood experiences shaped his entrepreneurial spirit, why midlife transitions are deeply necessary, and how self-love is one of the highest acts of love for your children.Blair explains how your parasympathetic nervous system — the “rest and digest” network — underpins your mental, physical, and emotional well-being. He emphasizes the vital role of feeling safe, connected, and curious in both health and personal evolution. His advice? Move every hour, sleep according to your chronotype, get sunlight in your eyes first thing in the morning, and start each day with intention. From daily mantras to longevity science from the Buck Institute, Blair's practical wisdom is packed with insights.The conversation also dives into actionable tips for parents on creating resilient, curious, and emotionally stable kids — without overprotecting them. Blair's candid reflection on failure, identity, and the modern health landscape is both refreshing and empowering. Whether you're looking to optimize your body, reconnect with your purpose, or better guide your children in the AI age, this episode delivers.Key TakeawaysChildhood wiring shapes lifelong behaviorSelf-love is essential for effective parentingAuthenticity is the key to a regret-free lifeSafety regulates the parasympathetic nervous systemYour nervous system is the root of health spanFrequent movement trumps long workoutsMorning sunlight resets your biological clockDaily mantras shift your brain's focusSitting is the new smoking — get up hourlyConnection is the #1 longevity multiplierFood is the most important input for your healthKids need a safe place to fail and growRandom acts of kindness heal both giver and receiverLearn More about Blair LaCorte:Websites: https://ppemastermind.com/ https://www.mastermindinnovate.com/ LinkedIn: https://www.linkedin.com/in/blair-lacorte-68084/YouTube: https://www.youtube.com/channel/UCTSlr8fDtSu4Ev_hF6tyqDwBiographical Information on Blair LaCorte:Blair LaCorte is a dynamic business executive who after being raised by two entrepreneurs has taken a path less traveled, unless of course you were Forrest Gump! His career spans numerous industries such as entertainment, aviation, AI, technology, aerospace, consulting, investing and military logistics. Renowned for his insatiable curiosity, collaborative spirit, passionate oratorical skills and competitive drive, Blair consistently strives to make a positive contribution and impact in all his endeavors.For Credibility: Blair has held CEO or “C” level strategy or operating roles in companies such PRG (largest live entertainment production company), XOJET/Vista (largest private aviation company), TPG (one of largest PE firms), Autodesk (largest CAD SW company), and Sun...

If you’re worried about memory loss or have a family history of Alzheimer’s, this episode is a must-listen. Angela sits down with world-renowned neurologist and author Dr. Dale Bredesen to unpack the groundbreaking science behind Alzheimer’s prevention and reversal—even if you carry the APOE4 gene. With over 30 years of research, Dr. Bredesen shares how to optimise your brain health through metabolic flexibility, inflammation control, and personalised interventions. In this powerful and deeply personal episode, Angela also opens up about her own genetic risk and experience caring for her mum with Alzheimer’s. They explore why cognitive decline is not inevitable and how Dr. Bredesen’s new book, The Ageless Brain, is putting the power back into your hands. Whether you're 35 or 75, the steps to preserve your cognition start now—and the tools have never been more accessible. KEY TAKEAWAYS: Alzheimer’s Is Preventable and Reversible: Dr. Bredesen explains how addressing root causes like inflammation, metabolic dysfunction, and toxicity can stop and even reverse cognitive decline. Perimenopause and Brain Fog: Oestrogen loss affects brain energy metabolism, making perimenopausal women more vulnerable to cognitive decline. Your Brain Runs on Supply & Demand: Cognitive health depends on supporting your brain’s high energy needs while reducing inflammatory load and toxic exposure. Check Your Cognitive Biomarkers Early: Blood markers like P-Tau217, GFAP, and A-beta42 can reveal risk decades before symptoms appear. Lifestyle = Medicine: Sleep quality, insulin sensitivity, resistance training, brain stimulation, and even stress reduction all play a critical role. GLP-1s and Alzheimer’s Risk: While popular for weight loss, these drugs may negatively impact cognition in some people—especially APOE4 homozygotes. TIMESTAMPS AND KEY TOPICS:0:00 – Introduction 6:48 – Pathogens, toxins, and the real cause of Alzheimer’s 13:32 – Menopause, oestrogen, and female brain vulnerability 24:05 – Judy’s story: reversing cognitive decline for 13+ years 32:18 – Most common risky behaviours for brain degeneration 42:21 – Best exercises for insulin sensitivity and cognition 51:10 – Supplements that protect brain structure & function 54:22 – How to use The Ageless Brain as a practical guide 58:45 – Final thoughts + where to learn more from Dr. Bredesen VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend A BIG thank you to our sponsors who make the show possible: Get 20% off the Creatine I love at trycreate.co/ANGELA20, and use code ANGELA20 to save 20% on your firsts order. Brain Boost: Try Neuro Regenerate at lvluphealth.com/angela and use code ANGELA15 to save 15% ABOUT THE GUEST Dale Bredesen, M.D. is an expert in the mechanisms of neurodegenerative diseases such as Alzheimer's disease. He is a graduate of Caltech, and received his MD from Duke University Medical Center. His career has included serving as Chief Resident in Neurology at the University of California, San Francisco, and served as a NIH Postdoctoral Fellow. His faculty position included working at UCSF, UCLA, and the University of California, San Diego. He was the director of the Program on Aging at the Burnham Institute. He was the founding President and CEO of the Buck Institute. He has developed a new therapeutic approach to treating Alzheimer's disease. He is the author of The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline. Dr Dale Bredesen’s latest book: The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime - https://amzn.eu/d/gdrjKQm https://www.apollohealthco.com/ https://www.instagram.com/drdalebredesen/ https://www.facebook.com/drdalebredesen/ ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast. This Podcast has been brought to you by Disruptive Media. https://disruptivemedia.co.uk/

In this episode of Ageless Athlete, we dive into the metabolic engine room with Dr. Brianna Stubbs—world-class endurance athlete and leading researcher at the Buck Institute for Research on Aging. Brianna bridges the worlds of elite performance and cutting-edge science, specializing in how ketones, fasting, and metabolic flexibility can shape our ability to recover, sustain energy, and age well.This isn't about dieting fads or silver bullets—it's about understanding how your body fuels itself, and how those energy pathways evolve over time. Whether you're an endurance athlete or someone simply trying to stay strong into your 40s, 50s, and beyond, Brianna's insights will give you a fresh way to think about performance and longevity.

This week on the WHOOP Podcast, WHOOP Founder and CEO Will Ahmed sits down with WHOOP SVP of Research, Algorithms, and Data Emily Capodilupo to break down an exciting new feature: Healthspan with WHOOP Age and Pace of Aging. Developed in collaboration with the Buck Institute for Research on Aging, WHOOP has created the ultimate longevity metric to understand your physiological age, measuring varying components of sleep, strain, and fitness. Will and Emily introduce the 9 metrics that make up your WHOOP Age and Pace of Aging: sleep consistency, hours of sleep, time in heart rate zones 1-3 and 4-5, strength training, steps, VO₂ Max, resting heart rate, and lean body mass. Healthspan with WHOOP Age and Pace of Aging is now available with WHOOP Peak and WHOOP Life memberships. Healthspan is not available for users under the age of 18.(00:00) What is Healthspan?(8:27) WHOOP Partnership with the Buck Institute(9:30) Why Healthspan? What does WHOOP measure to create this metric? (13:57) WHOOP Age and Pace of Aging (19:16): The 9 Metrics of Healthspan (19:46) Sleep Consistency (23:22) Hours of Sleep(27:28) Time in HR Zones 1-3 and HR Zones 4-5(31:39) Strength Training(35:31) Steps(38:28) VO₂ Max(41:15) Resting Heart Rate(44:14) Lean Body Mass(45:37) The Healthspan Algorithm(48:28) Heathspan Page & The Health Tab(49:12) Coaching people toward a healthier and longer life Support the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Instagram TikTok X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn

Your brain isn't just wired—it's mapped biochemically, and those signals may hold the key to longevity. In this episode, Dr. Graham Taylor sits down with Dr. Jennifer Garrison, a leading researcher at the Buck Institute for Research on Aging and an adjunct assistant professor of gerontology. Dr. Garrison's groundbreaking work focuses on neuropeptides—the brain's chemical messengers—and their powerful influence on aging, behavior, and reproductive decline. Using cutting-edge techniques, she investigates how neuropeptide shifts impact longevity and explores the intricate brain-ovary connection, a key yet often overlooked factor in women's health. A recipient of prestigious honors, including the Alfred P. Sloan Research Fellowship, Dr. Garrison is at the forefront of research aimed at unlocking new interventions for age-related conditions. Join us as we dive into her pioneering discoveries and discuss how understanding these biochemical signals could transform our approach to aging—especially for women's health and longevity.   For more information about Dr. Jennifer Garrison and Garrison Lab, please visit: https://garrisonlab.com For more information about Productive Health and the Productive Health Global Consortium, please visit: https://gcrle.org If you would like to support the Global Consortium for Reproductive Longevity and Equality, please consider donating: https://secure.qgiv.com/for/centerforhealthyaginginwomen/ Connect with Buck Institute for Research on Aging on Instagram at: https://www.instagram.com/buckinstituteforaging/ Connect with Buck Institute for Research on Aging on Linkedin at: https://www.linkedin.com/company/buck-institute-for-research-on-aging/ Connect with Buck Institute for Research on Aging on YouTube at: https://www.youtube.com/channel/UClKDVsCWOcAxUXgVyaIGVdw

Aging Research in Women takes center stage as Dr. Jennifer Garrison uncovers the overlooked reality that ovaries age faster than any other organ. This rapid aging, occurring at a rate two and a half times quicker than other tissues, significantly impacts women's health spans. From heightened cardiovascular risks to osteoporosis, the consequences of accelerated ovarian aging are vast, especially post-menopause. Yet, ovarian health research has long suffered from severe underfunding. At the Buck Institute for Research on Aging, Garrison's work aims to address this deficit by understanding the brain-ovary signaling axis, which she believes is key to promoting healthier aging for women. Sponsored by Qualia Senolytic: https://qualialife.com/podcastoffer. Use code podcast when you shop Qualia Senolytic for 15% off your order. Get in touch. Instagram: https://www.instagram.com/qualialife. Facebook: https://www.facebook.com/qualialife. Email: support@qualialife.com.

What if aging wasn't inevitable, but something you could slow—or even reverse? In this episode of “The Dr. Hyman Show,” Dr. Eric Verdin, the president of the Buck Institute for Research on Aging, and I dive deep into the science of longevity. Discover how lifestyle choices, mitochondrial health, and cutting-edge research are transforming our understanding of aging. From fasting and nutrient sensing to emerging therapies like CD38 inhibitors, this episode reveals actionable insights to help you live a longer, healthier life. In this episode, we discuss: The Role of Mitochondria in Aging The Critical Role of NAD Levels and Aging Lifestyle Interventions for Longevity Gene Therapy The Importance of CD38 and Enzyme Inhibition View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman's Weekly Longevity Journal This episode is brought to you by Rupa Health, BIOptimizers, LMNT, and Fatty 15. Streamline your lab orders with Rupa Health. Access more than 3,500 specialty lab tests and register for a FREE live demo at RupaHealth.com. Don't let stress take over your holidays. Try Magnesium Breakthrough from BiOptimizers. Head to Bioptimizers.com/Hyman and use code HYMAN10 to save 10%. LMNT is giving listeners a FREE eight-count sample pack of their vital electrolyte drink mix with any purchase. Just visit DrinkLMNT.com/Hyman today. Fatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 15% off a 90-day starter kit subscription. Just visit Fatty15.com and use code DRHYMAN10 to get started. Learn more about your ad choices. Visit megaphone.fm/adchoices