Podcasts about buck institute

Inflammation is the body's natural way of healing, but when it becomes chronic and hidden, it quietly drives many of today's most common health problems—heart disease, diabetes, dementia, cancer, autoimmune conditions, and more. Unlike the redness and swelling from a cut or sprain, this “silent inflammation” often goes unnoticed while slowly damaging tissues and speeding up aging. Modern life fuels the fire: processed foods, food additives, pollution, plastics, chronic stress, too much sitting, and poor sleep. The good news is inflammation can be calmed by simple daily choices—eating colorful whole foods like berries, leafy greens, beans, nuts, seeds, and omega-3 rich fish; adding herbs and spices like turmeric and cumin; moving regularly; practicing relaxation; and repairing gut health. Even small shifts, like climbing stairs, eating within a shorter window, or reducing sugar, can make a big difference. By lowering inflammation, the body finds balance again, opening the door to more energy, resilience, and healthy aging. In this episode, I discuss, along with Dr. Shilpa Ravella and Dr. David Furman, why it's important to be aware of systemic inflammation and how to address it. Dr. Ravella is a gastroenterologist and Assistant Professor of Medicine at Columbia University Medical Center. She is the author of A Silent Fire: The Story of Inflammation, Diet & Disease, which investigates inflammation—the hidden force at the heart of modern disease. Her writing has appeared in The Atlantic, New York Magazine, The Wall Street Journal, TIME, Slate, Discover, and USA Today, among other publications.  Dr. David Furman is Associate Professor and Director of the Bioinformatics Core at the Buck Institute for Research on Aging, as well as the Director of the Stanford 1000 Immunomes Project. He obtained his doctoral degree in immunology from the School of Medicine, University of Buenos Aires, Argentina, for his work on cancer immune-surveillance. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans. He has published nearly thirty scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others.  This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN to save 15%. Full-length episodes can be found here:What Causes Inflammation And How Can You Treat It? The Silent Killer: Inflammation And Chronic Disease How Silent Inflammation Accelerates Aging

BUFFALO, NY — September 4, 2025 — A new #research perspective was #published in Volume 17, Issue 8 of Aging (Aging-US) on August 16, 2025, titled “Age-related diseases as a testbed for anti-aging therapeutics: the case of idiopathic pulmonary fibrosis.” In this research perspective, Alex Zhavoronkov, Dominika Wilczok, Feng Ren, and Fedor Galkin, from Insilico Medicine, Buck Institute for Research on Aging, and Duke University, propose a new method to evaluate age-related diseases based on how closely they align with the biological processes of aging. Their analysis shows that idiopathic pulmonary fibrosis (IPF), a progressive lung condition, is one of the diseases most strongly associated with aging. This makes IPF a promising model for testing new anti-aging therapies with the potential to treat multiple age-related conditions. “This perspective explores how aging-related diseases (ARDs) can serve as experimental platforms for discovering new geroprotective interventions.” While many age-related diseases are used as models for aging research, not all accurately reflect the biology of aging. To address this, the authors developed a scoring system that measures how closely a disease is connected to the key hallmarks of aging, such as inflammation, genetic instability, and impaired cellular repair. Using this system, they evaluated 13 common age-related diseases and found that IPF had a particularly high overlap with aging biology. IPF is a chronic disease that causes scarring in the lungs and a rapid decline in lung function. In contrast to the gradual loss of function seen in normal aging, IPF progresses more than five times faster. The authors highlight that IPF shares nearly all of the biological features associated with aging. These similarities make IPF a strong candidate for studying aging and testing therapies that target its underlying causes. The authors also discuss different therapies currently being developed for IPF that are also designed to address aging itself. These include drugs that clear senescent cells, activate telomerase to maintain chromosome health, or repair damaged signaling between cells. Some of these treatments, such as senolytic combinations and AI-discovered compounds like rentosertib, are already showing early promise in preclinical or clinical trials. In addition, the authors point out that IPF's fast progression and clearly measurable outcomes offer an advantage for clinical testing. If a therapy proves effective in IPF, it may also be useful for other conditions that share similar aging-related mechanisms, including diabetes, arthritis, and heart disease. This approach could accelerate drug development and reduce costs by focusing on therapies that target shared biological pathways. Overall, this perspective supports a shift in pharmaceutical research toward treating aging as an underlying cause of many chronic diseases. By positioning IPF as a model for aging-related drug development, the authors propose a strategic pathway for testing and expanding anti-aging therapies across a wide range of health conditions. DOI - https://doi.org/10.18632/aging.206301 Corresponding author - Alex Zhavoronkov – alex@insilico.com Video short - https://www.youtube.com/watch?v=p5ur7itzvSI Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

As the global population grows older, understanding what drives the aging process is becoming increasingly important. Diseases like Alzheimer's, cardiovascular conditions, and cancer are more common with age, yet many current treatments only manage symptoms rather than addressing the underlying biological causes. One contributor to aging is the buildup of “senescent” cells—cells that have stopped dividing but do not die. These cells can harm nearby tissues by releasing molecular signals, a process known as secondary senescence. Scientists have found that senescent cells release tiny particles called exosomes. A research team from The Buck Institute for Research on Aging recently discovered that these exosomes carry aging-related messages through the bloodstream. Their study, titled “Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures,” was featured as the cover article in Aging (Aging-US), Volume 17, Issue 8. Full blog - https://aging-us.org/2025/09/how-exosomes-spread-aging-signals-and-could-support-anti-aging-research/ Paper DOI - https://doi.org/10.18632/aging.206292 Corresponding author - Birgit Schilling - bschilling@buckinstitute.org Video short - https://www.youtube.com/watch?v=tcyAZahw-g8 Sign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206292 Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts Keywords - aging, proteomics, senescence, exosomes, data-independent acquisitions To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

In this episode of Longevity by Design, Dr. Gil Blander welcomes Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging. Eric discusses the science behind therapeutic plasma exchange (TPE) and its potential to slow biological aging in humans. The conversation explores findings from a recent clinical trial, including measurable age reversal using epigenetic clocks.Eric explains how removing and replacing plasma can dilute pro-aging factors in the blood, a concept inspired by earlier animal studies on parabiosis. He also describes why rigorous, placebo-controlled human trials are crucial for validating longevity interventions and distinguishing the field from hype-driven wellness trends.The episode also highlights how omics data, such as metabolomics and proteomics, are shaping a new era of precision aging research. Eric emphasizes the value of lifestyle interventions as a foundation and sees future opportunities in combining TPE with personalized strategies to extend healthspan.  Guest-at-a-Glance

BUFFALO, NY — September 2, 2025 — A new #research paper featured on the #cover of Volume 17, Issue 8 of Aging (Aging-US) was #published on July 30, 2025, titled “Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures.” In this study, led by first authors Sandip Kumar Patel and Joanna Bons, along with corresponding author Birgit Schilling from The Buck Institute for Research on Aging, researchers found that exosomes—tiny particles released by cells—carry molecular signatures that indicate both biological aging and cellular senescence. These signatures include proteins, lipids, and microRNAs associated with inflammation, oxidative stress, and tissue remodeling. The findings could enhance our understanding of biological aging and help in developing future anti-aging therapies. Senescence is a state in which cells stop dividing but remain metabolically active. These cells often release harmful substances, known collectively as the senescence-associated secretory phenotype (SASP), that can affect nearby tissues. This study shows that exosomes are an important component of this secretory profile. The researchers analyzed exosomes from senescent human lung cells and from the blood plasma of both young and older adults. They identified over 1,300 proteins and 247 lipids within these particles. Many of these molecules were significantly altered with age. “In parallel, a small human plasma cohort from young (20–26 years) and old (65–74 years) individuals revealed 1,350 exosome proteins and 171 plasma exosome proteins were altered in old individuals.” Exosomes from older individuals contained more inflammation-related proteins and fewer antioxidants, while those from senescent cells showed lipid changes associated with membrane integrity and cellular stress. These changes suggest that exosomes may play a role in spreading senescence to nearby cells, a process known as secondary senescence. The study also identified distinct patterns in microRNAs—small molecules that regulate gene expression—found in the blood of older adults. Some of these, including miR-27a and miR-874, have previously been associated with cognitive decline and chronic illnesses, highlighting their potential as biomarkers for biological aging. Although the study involved a limited number of samples, it provides strong early evidence that exosomes reflect the molecular changes associated with aging. By showing how these particles carry and possibly spread aging-related signals throughout the body, the research opens new possibilities for diagnosing and treating age-related diseases. DOI - https://doi.org/10.18632/aging.206292 Corresponding author - Birgit Schilling – bschilling@buckinstitute.org Video short - https://www.youtube.com/watch?v=tcyAZahw-g8 Keywords - aging, proteomics, senescence, exosomes, data-independent acquisitions Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us: Facebook - https://www.facebook.com/AgingUS/ X - https://twitter.com/AgingJrnl Instagram - https://www.instagram.com/agingjrnl/ YouTube - https://www.youtube.com/@AgingJournal LinkedIn - https://www.linkedin.com/company/aging/ Bluesky - https://bsky.app/profile/aging-us.bsky.social Pinterest - https://www.pinterest.com/AgingUS/ Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc MEDIA@IMPACTJOURNALS.COM

Did you know that your ovaries are so much more than just for making babies? They don't just die after menopause and today we are going to learn so much more about their function, HRT and so much more with California OB-GYN Dr. Lizellen LaFollette We cover: How she treated her patients after the WHI came down with the headlines that estrogen causes cancer…which btw, it doesn't What her vision is for the future of menopause research and treatments for women What she learned at the Buck Institute of Aging through her research on ovarian aging And so much more Dr. Lizellen LaFollette is a board-certified OB-GYN with more than three decades of experience caring for women in the Bay Area in obstetrics, gynecology, menopause and aesthetics. Based in Greenbrae, California, she is known for her leadership in minimally invasive gynecologic surgery. In addition to her clinical practice, Dr. LaFollette has been an investigator and advisor for multiple studies in women's health, including research on preterm labor risk, inflammation biomarkers, and reproductive longevity through her work with the Buck Institute's Reproductive Longevity Consortium.  She is so often voted “Top Doctor” by her local journals. And is committed to evidence-based, patient-centered care. Her areas of focus include menopause management, reproductive aging, and reducing unnecessary cesarean sections, while continuing to integrate the latest innovations to improve women's health across the lifespan. You're going to love this conversation CONTACT Email: office@drlafollette.com Instagram: https://www.instagram.com/drlafollette/ Website: https://drlafollette.com   Give thanks to our sponsors: Try Vitali skincare. 20% off with code ZORA here. Get Primeadine spermidine by Oxford Healthspan. 15% discount with code ZORA ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠here⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠. Get Mitopure Urolithin A by Timeline. 20% discount with code ZORA at https://timeline.com/zora Try Suji to improve muscle 10% off with code ZORA at TrySuji.com https://trysuji.com Try OneSkin skincare with code ZORA for 15% off https://oneskin.pxf.io/c/3974954/2885171/31050 Join ⁠⁠⁠Biohacking Menopause⁠⁠⁠ before October 1, 2025 to win a Flexbeam Red Light Therapy Device. Or save 10% with code ZORA at recharge.health   Join the Hack My Age community on: YouTube: https://youtube.com/@hackmyage Facebook Page: ⁠⁠⁠⁠⁠@⁠Hack My Age⁠       Facebook Group: ⁠⁠⁠⁠⁠⁠@⁠Biohacking Menopause⁠⁠⁠⁠⁠⁠ ⁠  Private Women's Only Support Group: https://hackmyage.com/biohacking-menopause-membership/ Instagram: ⁠⁠⁠⁠⁠@⁠HackMyAge⁠    Website: ⁠⁠⁠⁠⁠⁠HackMyAge.com⁠   

In the opening pages of my guest's book, she recounts a colleague's bumpy plane ride that provided the insight for the title of the book, Taming the Turbulence in Educational Leadership: “We are facing turmoil in education, and the job of good leaders is to 'tame the turbulence'...educators have been caught in this turbulence; it permeates our profession and we haven't been able to get above it. As a result, it is the role of leaders to help teachers see how even small, simple shifts can change a child's experience of school.”Rooted in real-world stories, Taming the Turbulence offers solidarity and actionable strategies to education leaders committed to centering the needs of all learners in increasingly polarized societies.And the author, Jennifer D. Klein, is an experienced educator and advocate for student-centered, experiential learning as a catalyst for positive social change. With two-decades of classroom teaching across a number of diverse international settings, as a teacher in Costa Rica and a school leader in Colombia, she now focuses on inspiring and training educators worldwide, working with groups like What School Could Be, The Institution for International Education, and The Buck Institute. Her previous books include The Global Education Guidebook: Humanizing K–12 Classrooms Worldwide Through Equitable Partnerships and The Landscape Model of Learning: Designing Student-Centered Experiences for Cognitive and Cultural Inclusion, coauthored with Kapono Ciotti, who we spoke with about that work back in episode 159.You can connect with Jennifer at principledlearning.orgTaming the Turbulence in Educational Leadership from Corwin

Could saying no actually be your best longevity strategy? Blair LaCorte reveals why avoiding over-optimization and focusing on system biology, compassion, and purpose instead leads to authentic biosynergy and lasting vitality. Meet our guest Blair LaCorte is a dynamic business executive whose career spans entertainment, aviation, AI, technology, aerospace, consulting, investing & military logistics. He has held CEO & C-level roles at leading companies like PRG, XOJET/Vista, TPG, Autodesk & Oracle, while also taking startups such as AEye Technologies & VerticalNet to IPO. Currently an astronaut-in-training with Virgin Galactic & Vice Chairman of the Buck Institute, Blair continues to drive innovation, growth & global impact. Thank you to our partners Outliyr Biohacker's Peak Performance Shop: get exclusive discounts on cutting-edge health, wellness, & performance gear Ultimate Health Optimization Deals: a database of of all the current best biohacking deals on technology, supplements, systems and more Latest Summits, Conferences, Masterclasses, and Health Optimization Events: join me at the top events around the world FREE Outliyr Nootropics Mini-Course: gain mental clarity, energy, motivation, and focus Key takeaways Tech is for control, not a cure all Forgetting biology leads to problems, not progress Over optimizing health with gadgets causes new problems Step back & look at the whole picture Scientific knowledge & personal belief both affect your biology & well being more than most realize Staying healthy is better than only reacting to sickness Small daily choices matter more than silver bullets Focus on what works for you Test, observe, & stick with what fits your life & makes you feel good Relationships lower stress & boost your immune system Loneliness is a major health risk at any age Some stress helps growth Chronic unbroken stress harms your body Find ways to activate & calm yourself Knowing health tips isn't enough Build habits you enjoy, ideally with friends or community support, for lasting results No two people are alike Track your own changes & work out routines & diets that fit you specifically Modern testing makes it easier to spot issues early Keep personal health records to track your biomarkers over time Episode highlights 04:19 Why Technology Alone Won't Save Your Health 21:17 The Real Framework for Habit Change That Works 28:50 What Truly Multiplies Healthspan Results 36:44 Practical Ways to Strengthen Connection & Reduce Stress 46:28 How to Personalize Health in a Complex World Links Watch it on YouTube: https://youtu.be/U2QuhPEugq4 Full episode show notes: outliyr.com/223 Connect with Nick on social media Instagram Twitter (X) YouTube LinkedIn Easy ways to support Subscribe Leave an Apple Podcast review Suggest a guest Do you have questions, thoughts, or feedback for us? Let me know in the show notes above and one of us will get back to you! Be an Outliyr, Nick

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Eric Verdin is a physician-scientist and the CEO of the Buck Institute for Research on Aging whose career has centered on understanding how epigenetics, metabolism, and the immune system influence the aging process. In this episode, Eric traces his scientific journey from studying viruses and histone deacetylases (HDACs) to leading aging research at the Buck Institute, offering insights into how aging impairs immune and nervous system function—including thymic shrinkage, chronic inflammation, and reduced vaccine response—and how these changes impact lifespan. He explores the metabolic underpinnings of aging, such as oxidative stress and insulin and IGF-1 signaling, and he discusses practical tools like zone 2 cardio, ketogenic diets, and GLP-1 drugs. The conversation also covers declining NAD levels with age, the roles of NAD-consuming enzymes such as sirtuins and CD38, and what current NAD-boosting strategies (like NMN, NR, and IV NAD) can and can't accomplish. Eric weighs in on promising longevity interventions including rapamycin, growth hormone for thymic regeneration, and anti-inflammatory therapies, while also examining the promise and limitations of current biological age tests and the potential of combining epigenetic, proteomic, and organ-specific metrics with wearables to guide personalized longevity care. We discuss: Eric's scientific journey from virology to the field of geroscience [2:45]; How dysfunction in the immune system and central nervous system can drive aging throughout the body [5:00]; The role of metabolism and oxidative stress in aging, and why antioxidant strategies have failed to deliver clear benefits [8:45]; Other aspects of metabolism linked to aging: mitochondrial efficiency, fuel utilization, and glucose-modulating drugs [16:30]; How inefficient glucose metabolism drives insulin, IGF-1 signaling, and accelerates aging [21:45]; The metabolic effects of GLP-1 agonists, and the need to move beyond crude metrics like BMI in favor of more precise assessments of metabolic health [27:00]; The case for immune health as a “fifth horseman” [36:00]; How the innate and adaptive immune systems work together to build immune memory [39:45]; Why vaccines lose effectiveness with age: shrinking of the thymus gland and diminished T-cell diversity [44:15]; Exploring growth hormone, thymic regeneration, and the role of exercise in slowing immune aging [48:45]; The challenges of identifying reliable biomarkers for immune function, and the potential of rapamycin analogs to enhance vaccine response in older adults [57:45]; How rapamycin's effects on the immune system vary dramatically by dosage and frequency [1:03:30]; The limitations of mouse models in aging research and the need for cautious interpretation of rapamycin's benefits in humans [1:08:15]; NAD, sirtuins, and aging: scientific promise amid commercial hype [1:15:45]; How CD38 drives age-related NAD decline, influences immune function, and may impact longevity [1:23:45]; How NMN and NR supplementation interact with CD38 and NAD metabolism, and potential risks like homocysteine elevation and one-carbon cycle depletion [1:31:00]; Intravenous NAD: limited evidence and serious risks [1:37:00]; Interleukin-11 (IL-11) as a new target in immune aging, the dual role of chronic inflammation in aging, and the need for better biomarkers to guide interventions [1:43:00]; Biological aging clocks: types of clocks, promise, major limitations, and future outlook [1:48:30]; The potential of proteomics-based aging clocks for detecting organ-specific decline and frailty [2:00:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Sponsor dieser Folge ist Kaneka Erfahre hier mehr: https://www.kaneka-ubiquinol.com/Wir danken Kaneka für die Unterstützung. Die Podcast-Inhalte bleiben aber stets unabhängig, das ist uns wichtig. _______________________________________________________________________________Heute spreche ich mit Professor Eric Verdin, einem der weltweit führenden Altersforscher und Präsidenten des Buck Institute for Research on Aging. Wir sprechen über nichts Geringeres als die Zukunft der Medizin: Wie KI, komplexe Biomarker und präventive Diagnostik unsere Gesundheit revolutionieren könnten – lange bevor Krankheiten entstehen. Eric gibt Einblicke in die PATH-Studie, diskutiert die Potenziale von Ketonkörpern gegen Alzheimer und erklärt, warum GLP-1-Rezeptor-Agonisten als erste globale Anti-Aging-Medikamente gelten könnten. Wissenschaft zum Staunen – verständlich und mitreißend erklärt. In dieser Folge sprechen wir u.a. über folgende Themen: - Wie können KI und Big Data die präventive Medizin revolutionieren? - Warum sind klassische Blutwerte nicht mehr ausreichend für eine moderne Gesundheitsdiagnostik? - Wie lassen sich Herzinfarkt und Alzheimer schon 15 Jahre im Voraus vorhersagen? - Was macht Ketonkörper und Ketoneester zu potenziellen Schutzfaktoren gegen Demenz? - Sind ketogene Diäten alltagstauglich – oder braucht es neue Wege zur Ketose? - Könnten GLP-1-Rezeptor-Agonisten wie Ozempic das erste echte Anti-Aging-Medikament sein? - Warum könnte die Insulinsensitivität der Schlüssel zur Lebensverlängerung sein? - Sind Mäuse als Modellorganismen für die Alternsforschung noch zeitgemäß – oder brauchen wir mehr Humanstudien? - Welche Bedeutung haben Biomarker des Alterns für personalisierte Medizin? - Weshalb wird chronische Entzündung als zentrales Kennzeichen des Alterns angesehen? - Welche Rolle spielt das Immunsystem beim biologischen Altern – und wie können wir es gezielt unterstützen? - Warum ist die Kommunikation wissenschaftlicher Erkenntnisse heute wichtiger denn je? Weitere Informationen zu Prof. Eric Verdin findest du hier: https://www.buckinstitute.org/ Du interessierst dich für Gesunde Langlebigkeit (Longevity) und möchtest ein Leben lang gesund und fit bleiben, dann folge mir auch auf den sozialen Kanälen bei Instagram, TikTok, Facebook oder YouTube. https://www.instagram.com/nina.ruge.official https://www.tiktok.com/@nina.ruge.official https://www.facebook.com/NinaRugeOffiziell https://www.youtube.com/channel/UCOe2d1hLARB60z2hg039l9g Disclaimer: Ich bin keine Ärztin und meine Inhalte ersetzen keine medizinische Beratung. Bei gesundheitlichen Fragen wende dich bitte an deinen Arzt/deine Ärztin. STY-207

In der morgigen Podcastfolge widmen wir uns dem spannenden Thema gesunde Langlebigkeit – und wie wir Krankheiten erkennen können, bevor sie überhaupt entstehen. Mein Gast ist Prof. Eric Verdin, Präsident des renommierten Buck Institute for Research on Aging. Gemeinsam sprechen wir über bahnbrechende Entwicklungen in der Altersforschung, neue Biomarker, die Rolle von Ketonkörpern und KI in der präventiven Medizin – und darüber, warum Gewichtsverlust-Medikamente wie GLP-1 als echte Anti-Aging-Wunder gelten könnten.  Du interessierst dich für Gesunde Langlebigkeit (Longevity) und möchtest ein Leben lang gesund und fit bleiben, dann folge mir auch auf den sozialen Kanälen bei Instagram, TikTok, Facebook oder YouTube. https://www.instagram.com/nina.ruge.official https://www.tiktok.com/@nina.ruge.official https://www.facebook.com/NinaRugeOffiziell https://www.youtube.com/channel/UCOe2d1hLARB60z2hg039l9g   Disclaimer:  Ich bin keine Ärztin und meine Inhalte ersetzen keine medizinische Beratung. Bei gesundheitlichen Fragen wende dich bitte an deinen Arzt/deine Ärztin.  STY-207 

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Brian Kennedy is a renowned biologist, leader in aging research, and director of the Center for Healthy Longevity at the National University of Singapore. In this episode, Brian shares insights from ongoing human aging studies, including clinical trials of rapamycin and how dosing strategies, timing, and exercise may influence outcomes. He presents two key models of aging—one as a linear accumulation of biological decline and the other as an exponential rise in mortality risk—and explains why traditional models of aging fall short. He also explains why most current aging biomarkers lack clinical utility and describes how his team is working to develop a more actionable biological clock. Additional topics include the potential of compounds like alpha-ketoglutarate, urolithin A, and NAD boosters, along with how lifestyle interventions—such as VO2 max training, strength building, and the use of GLP-1 and SGLT2 drugs—may contribute to longer, healthier lives. We discuss: Brian's journey from the Buck Institute to Singapore, and the global evolution of aging research [2:45]; Rethinking the biology of aging: why models like the hallmarks of aging fall short [9:45]; How inflammation and mTOR signaling may play a central, causal role in aging [14:15]; The biological role of mTOR in aging, and the potential of rapamycin to slow aging and enhance immune resilience [17:30]; Aging as a linear decline in resilience overlaid with non-linear health fluctuations [22:30]; Speculating on the future of longevity: slowing biological aging through noise reduction and reprogramming [33:30]; Evaluating the role of the epigenome in aging, and the limits of methylation clocks [39:00]; Balancing the quest for immortality with the urgent need to improve late-life healthspan [43:00]; Comparing the big 4 chronic diseases: which are the most inevitable and modifiable? [47:15]; Exploring potential benefits of rapamycin: how Brian is testing this and other interventions in humans [51:45]; Testing alpha-ketoglutarate (AKG) for healthspan benefits in aging [1:01:45]; Exploring urolithin A's potential to enhance mitochondrial health, reduce frailty, and slow aging [1:05:30]; The potential of sublingual NAD for longevity, and the combination of NAD and AKG for metabolic and exercise enhancement [1:09:00]; Other interventions that may promote longevity: spermidine, 17

BIO: Blair LaCorte is a dynamic executive with experience across entertainment, aviation, AI, aerospace, consulting, and more.STORY: Blair shares three catastrophic investment failures and the life-altering lessons that rewired his approach to wealth.LEARNING: Chase knowledge, not hype, and don't let greed hijack logic. Invest with friends only if you're willing to lose both. “The worst investment that you can make is to put your time into something that you don't enjoy or that you know is not going to work out.”Blair LaCorte Guest profileBlair LaCorte is a dynamic executive with experience across entertainment, aviation, AI, aerospace, consulting, and more. He has held CEO roles at companies such as PRG, XOJET, and Autodesk, and led startups to successful IPOs. Currently, he's training as an astronaut for Virgin Galactic and is Vice Chairman at the Buck Institute.Worst investment everFresh out of college at 22, Blair met a smooth-talking investor who flaunted his “lifetime monthly checks” from an oil well. Blinded by dollar signs and zero industry knowledge, he poured his savings into a single well.Blair ignored basic due diligence, diversification, and warnings about low-quality reserves. It was all about greed. He had seen someone make money where they got paid every month for the rest of their life, as long as the well lasted.The greed kept him in and kept him investing in the well. At the end of the day, the oil was of below-average quality and was not as much as they thought it would be. Blair's ignorance caused him a 100% loss. The well underperformed, and his greed trapped him in a sinking ship. Blair even commissioned a plaque to memorialize his shame—a daily reminder that “easy money” is a predator in disguise.Burning $200k and a friendshipAfter Blair's first IPO success in 1999, his roommate pitched him on Coffee.com—a visionary play on single-origin beans (decades before it became trendy). Blair invested early, then panicked as losses mounted. When the roommate begged for more capital, he refused because he did not think it would succeed, but guilt kept him from cutting ties.After a while, the startup imploded. Worse? Blair's friend never spoke to him again. He learned the hard truth from this unwise investment: mixing money with friendship is financial suicide.The $59.50 ego taxAt the peak of the dot-com boom, Blair had just scored a top-tier IPO. His broker urgently called and advised him to sell immediately at $59.50 as he believed the boom would not last. But pride convinced him that the broker was just chasing commissions.Blair held stubbornly as the stock bled out to $2. He lost $570,000 in vaporized gains. Blair's ego had bet against reality, and reality won.Lessons learnedChase knowledge, not hype, and don't let greed hijack logic. If you don't understand how the money is made, you're the exit strategy for someone else.Friends + money = atomic risk. Invest with friends only if you're willing to lose both on the same day.Pride is the silent portfolio killer. The market doesn't care about your ego, and exit signals don't negotiate.Your time is your ultimate currency. Grinding your years into a dying venture to ‘prove a point' is the costliest investment of all.Andrew's takeawaysMacro trumps micro. Brilliant ideas fail if they're too early or too late. Always ask: “Is the world ready for this?”Preserve capital like your life depends on it. A young you can risk time; an older you must protect...

In this conversation, Dr. Buck Joffrey and Dr. Julie Andersen explore the molecular mechanisms behind neurodegenerative diseases, with a particular focus on the aging brain. They discuss the brain's heightened vulnerability to aging, the impact of mitochondrial dysfunction, and the challenges posed by drug delivery across the blood-brain barrier. The conversation also delves into innovative strategies to support mitochondrial health, including the potential of lysosomal rejuvenators and senolytics, as well as the importance of identifying early biomarkers for neurodegenerative conditions. Dr. Andersen also underscores the critical role of lifestyle interventions—especially exercise—in maintaining brain health. Learn more about Dr. Julie Andersen and the Buck Institute: https://www.buckinstitute.org/lab/andersen-lab/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

******Support the channel******Patreon: https://www.patreon.com/thedissenterPayPal: paypal.me/thedissenterPayPal Subscription 1 Dollar: https://tinyurl.com/yb3acuuyPayPal Subscription 3 Dollars: https://tinyurl.com/ybn6bg9lPayPal Subscription 5 Dollars: https://tinyurl.com/ycmr9gpzPayPal Subscription 10 Dollars: https://tinyurl.com/y9r3fc9mPayPal Subscription 20 Dollars: https://tinyurl.com/y95uvkao ******Follow me on******Website: https://www.thedissenter.net/The Dissenter Goodreads list: https://shorturl.at/7BMoBFacebook: https://www.facebook.com/thedissenteryt/Twitter: https://x.com/TheDissenterYT This show is sponsored by Enlites, Learning & Development done differently. Check the website here: http://enlites.com/ Dr. Deena Emera is an evolutionary biologist, author, and teacher. She is a Senior Scientist and Writer-in-Residence in the Center for Reproductive Longevity and Equality at the Buck Institute, where she is drawing on her evolutionary background and expertise on female reproduction to investigate the evolution of menopause. She is the author of A Brief History of the Female Body: An Evolutionary Look at How and Why the Female Form Came to Be. In this episode, we focus on A Brief History of the Female Body. We start by discussing what a female is. We then go through traits like breasts, menstruation, the female orgasm, female love and sexual selection, pregnancy, motherhood and mother-offspring conflict, and menopause and the grandmother hypothesis.--A HUGE THANK YOU TO MY PATRONS/SUPPORTERS: PER HELGE LARSEN, JERRY MULLER, BERNARDO SEIXAS, ADAM KESSEL, MATTHEW WHITINGBIRD, ARNAUD WOLFF, TIM HOLLOSY, HENRIK AHLENIUS, FILIP FORS CONNOLLY, ROBERT WINDHAGER, RUI INACIO, ZOOP, MARCO NEVES, COLIN HOLBROOK, PHIL KAVANAGH, SAMUEL ANDREEFF, FRANCIS FORDE, TIAGO NUNES, FERGAL CUSSEN, HAL HERZOG, NUNO MACHADO, JONATHAN LEIBRANT, JOÃO LINHARES, STANTON T, SAMUEL CORREA, ERIK HAINES, MARK SMITH, JOÃO EIRA, TOM HUMMEL, SARDUS FRANCE, DAVID SLOAN WILSON, YACILA DEZA-ARAUJO, ROMAIN ROCH, DIEGO LONDOÑO CORREA, YANICK PUNTER, CHARLOTTE BLEASE, NICOLE BARBARO, ADAM HUNT, PAWEL OSTASZEWSKI, NELLEKE BAK, GUY MADISON, GARY G HELLMANN, SAIMA AFZAL, ADRIAN JAEGGI, PAULO TOLENTINO, JOÃO BARBOSA, JULIAN PRICE, HEDIN BRØNNER, DOUGLAS FRY, FRANCA BORTOLOTTI, GABRIEL PONS CORTÈS, URSULA LITZCKE, SCOTT, ZACHARY FISH, TIM DUFFY, SUNNY SMITH, JON WISMAN, WILLIAM BUCKNER, PAUL-GEORGE ARNAUD, LUKE GLOWACKI, GEORGIOS THEOPHANOUS, CHRIS WILLIAMSON, PETER WOLOSZYN, DAVID WILLIAMS, DIOGO COSTA, ALEX CHAU, AMAURI MARTÍNEZ, CORALIE CHEVALLIER, BANGALORE ATHEISTS, LARRY D. LEE JR., OLD HERRINGBONE, MICHAEL BAILEY, DAN SPERBER, ROBERT GRESSIS, JEFF MCMAHAN, JAKE ZUEHL, BARNABAS RADICS, MARK CAMPBELL, TOMAS DAUBNER, LUKE NISSEN, KIMBERLY JOHNSON, JESSICA NOWICKI, LINDA BRANDIN, VALENTIN STEINMANN, ALEXANDER HUBBARD, BR, JONAS HERTNER, URSULA GOODENOUGH, DAVID PINSOF, SEAN NELSON, MIKE LAVIGNE, JOS KNECHT, LUCY, MANVIR SINGH, PETRA WEIMANN, CAROLA FEEST, MAURO JÚNIOR, 航 豊川, TONY BARRETT, NIKOLAI VISHNEVSKY, STEVEN GANGESTAD, TED FARRIS, ROBINROSWELL, KEITH RICHARDSON, HUGO B., AND JAMES!A SPECIAL THANKS TO MY PRODUCERS, YZAR WEHBE, JIM FRANK, ŁUKASZ STAFINIAK, TOM VANEGDOM, BERNARD HUGUENEY, CURTIS DIXON, BENEDIKT MUELLER, THOMAS TRUMBLE, KATHRINE AND PATRICK TOBIN, JONCARLO MONTENEGRO, NICK GOLDEN, CHRISTINE GLASS, IGOR NIKIFOROVSKI, AND PER KRAULIS!AND TO MY EXECUTIVE PRODUCERS, MATTHEW LAVENDER, SERGIU CODREANU, ROSEY, AND GREGORY HASTINGS!

Did you know you can detect Alzheimer's risk in your 20s with a simple blood test? In this Habits and Hustle episode, I sit down with Dr. Dale Bredesen, the first scientist to successfully reverse Alzheimer's disease. We explore the three major causes of cognitive decline, why your brain fog might be pre-Alzheimer's, and the shocking truth about everyday toxins like sushi, hair dye, and microplastics. We also dive into the KetoFlex 12-3 protocol and why 45 million Americans are headed for Alzheimer's. From sleep apnea's brain damage to the surprising benefits of saunas and cold plunges, this episode transforms everything you thought you knew about brain health. Dr. Dale Bredesen is an internationally recognized expert in neurodegenerative diseases and creator of the ReCODE Protocol™. He earned his M.D. from Duke University, served as founding President and CEO of the Buck Institute, and is author of the New York Times bestseller The End of Alzheimer's. What We Discuss:  (01:00) - Reversing Alzheimer's (14:53) - Toxins and Brain Health (21:31) - Brain Health and Sleep Quality (36:01) - Toxins and Dietary Choices (41:16) - Optimizing Brain Health Through Lifestyle (50:55) - Reversing Inflammation and Brain Decline (58:23) - Toxins, Mitochondria, and Cognitive Health (01:19:40) - Differentiating Dementia From Alzheimer's (01:23:59) - Achieving Optimal Brain Health Through Diet (01:27:50) - Restoring Brain Energy With Ketones …and more! Thank you to our sponsors: Momentous: Shop this link and use code Jen for 20% off Therasage: Head over to therasage.com and use code Be Bold for 15% off  TruNiagen: Head over to truniagen.com and use code HUSTLE20 to get $20 off any purchase over $100. Magic Mind: Head over to www.magicmind.com/jen and use code Jen at checkout. Bio.me: Link to daily prebiotic fiber here, code Jennifer20 for 20% off.  David: Buy 4, get the 5th free at davidprotein.com/habitsandhustle.   Find more from Jen:  Website: https://www.jennifercohen.com/ Instagram: @therealjencohen   Books: https://www.jennifercohen.com/books Speaking: https://www.jennifercohen.com/speaking-engagement Find more from Dr. Dale Bredesen: Website: https://www.apollohealthco.com/dr-bredesen/  Instagram: https://www.instagram.com/apollohealthco/

Dr. Brianna Stubbs, director of Translational Science at the Buck Institute for Research on Aging, explores the science behind ketone metabolism and its benefits for women. Learn how ketones can support your fitness goals, regulate appetite, aid in recovery, and even contribute to healthy brain aging. This episode is full of actionable insights and valuable tips for incorporating ketones into your wellness routine.KETONE-IQ Get 30% off when you Subscribe & Save at https://ketone.com/STEPHANIEEpisode Overview (timestamps are approximate):(10:00) Optimizing Performance With Ketones(23:00) Ketones and Appetite Regulation(28:00) Ketones and Muscle Protection(36:00) Ketones, Exercise, and Muscle Metabolism(43:00) Strategic Use of Ketones for Performance(48:00) Ketones for Energy and Recovery(53:00) Ketones and Cellular Aging(1:04:00) Advancing Biomarkers for Healthy Aging(1:09:00) BONUS the “After-Party” with Dr. StephanieResources mentioned in this episode acn be found at https://drstephanieestima.com/podcasts/ep422We are grateful to our sponsors:LVLUP - Midlife hormonal changes can wreak havoc on your gut health. Ultimate GI Repair combines powerful gut-healing peptides with gut-nourishing naturals to soothe your changing digestion. Learn more at https://lvluphealth.com/DRSTEPHANIE and use code DRSTEPHANIE for 15% offONESKIN - Harness the power of peptides for fuller hair and glowing skin. Save 15% at https://oneskin.co/better with code BETTER.EQUIP COLLAGEN - Support bones, joints, gut, and skin with Equip Collagen. Get 20% off at https://equipfoods.com/better with code BETTER.LMNT - Rehydrate with the perfect mix of sodium, potassium, and magnesium. Get a free sample pack at https://drinklmnt.com/drestima.

Send us a textIn this episode of Causes or Cures, we explore insights into brain health and longevity with NYT bestselling author and neurologist Dr. Dale Bredesen.Dr. Bredesen explains why he believes cognitive decline is not an inevitable part of aging and outlines six biological processes he identifies as impacting brain aging. He also shares practical tools he recommends for assessing how well your mind is functioning. We discuss the alarming rise in early-onset dementia among people in their 30s and 40s and the potential causes behind this increase. Dr. Bredesen also talks about the links between COVID, sugar intake, and dementia risk. He offers science-based advice on diet, sleep, and lifestyle strategies that support an ageless brain.Additionally, Dr. Bredesen addresses how the for-profit healthcare system can hinder Alzheimer's management and shares his comprehensive ReCODE Protocol™, which he presents as a promising approach to preventing and potentially reversing cognitive decline, though it has sparked passionate discussions and differing opinions in the Alzheimer's and broader medical communities.About Dr. Dale Bredesen Dr. Bredesen is an internationally recognized expert in neurodegenerative diseases and the author of The Ageless Brain and The End of Alzheimer's Disease. He earned his M.D. from Duke University Medical Center, completed his neurology residency at UCSF, and was an NIH Postdoctoral Fellow in Nobel laureate Stanley Prusiner's laboratory. He has held faculty positions at UCSF, UCLA, and UC San Diego, and was founding President and CEO of the Buck Institute for Research on Aging. Dr. Bredesen's pioneering research has led to innovative treatments and the development of the ReCODE Protocol™, offering new hope in the fight against Alzheimer's disease.You can contact Dr. Eeks at bloomingwellness.com.Follow Eeks on Instagram here.Or Facebook here.Or X.On Youtube.Or TikTok.SUBSCRIBE to her monthly newsletter here.Support the show

What do aviation, AI, parenting, and longevity have in common? Blair LaCorte. In this fast-paced episode, Episode 243 of the Fit Father Project Podcast, he shares with Dr. Anthony Balduzzi the biggest lessons from his high-performance life — and how we can all build a stronger body, mind, and purpose. Together, they explore the powerful idea that safety — both physical and emotional — is the foundation for longevity, authentic living, and effective parenting. Blair shares how formative childhood experiences shaped his entrepreneurial spirit, why midlife transitions are deeply necessary, and how self-love is one of the highest acts of love for your children.Blair explains how your parasympathetic nervous system — the “rest and digest” network — underpins your mental, physical, and emotional well-being. He emphasizes the vital role of feeling safe, connected, and curious in both health and personal evolution. His advice? Move every hour, sleep according to your chronotype, get sunlight in your eyes first thing in the morning, and start each day with intention. From daily mantras to longevity science from the Buck Institute, Blair's practical wisdom is packed with insights.The conversation also dives into actionable tips for parents on creating resilient, curious, and emotionally stable kids — without overprotecting them. Blair's candid reflection on failure, identity, and the modern health landscape is both refreshing and empowering. Whether you're looking to optimize your body, reconnect with your purpose, or better guide your children in the AI age, this episode delivers.Key TakeawaysChildhood wiring shapes lifelong behaviorSelf-love is essential for effective parentingAuthenticity is the key to a regret-free lifeSafety regulates the parasympathetic nervous systemYour nervous system is the root of health spanFrequent movement trumps long workoutsMorning sunlight resets your biological clockDaily mantras shift your brain's focusSitting is the new smoking — get up hourlyConnection is the #1 longevity multiplierFood is the most important input for your healthKids need a safe place to fail and growRandom acts of kindness heal both giver and receiverLearn More about Blair LaCorte:Websites: https://ppemastermind.com/ https://www.mastermindinnovate.com/ LinkedIn: https://www.linkedin.com/in/blair-lacorte-68084/YouTube: https://www.youtube.com/channel/UCTSlr8fDtSu4Ev_hF6tyqDwBiographical Information on Blair LaCorte:Blair LaCorte is a dynamic business executive who after being raised by two entrepreneurs has taken a path less traveled, unless of course you were Forrest Gump! His career spans numerous industries such as entertainment, aviation, AI, technology, aerospace, consulting, investing and military logistics. Renowned for his insatiable curiosity, collaborative spirit, passionate oratorical skills and competitive drive, Blair consistently strives to make a positive contribution and impact in all his endeavors.For Credibility: Blair has held CEO or “C” level strategy or operating roles in companies such PRG (largest live entertainment production company), XOJET/Vista (largest private aviation company), TPG (one of largest PE firms), Autodesk (largest CAD SW company), and Sun Microsystems / Oracle...

What do aviation, AI, parenting, and longevity have in common? Blair LaCorte. In this fast-paced episode, Episode 153 of the Fit Mother Project Podcast, he shares with Dr. Anthony Balduzzi the biggest lessons from his high-performance life — and how we can all build a stronger body, mind, and purpose. Together, they explore the powerful idea that safety — both physical and emotional — is the foundation for longevity, authentic living, and effective parenting. Blair shares how formative childhood experiences shaped his entrepreneurial spirit, why midlife transitions are deeply necessary, and how self-love is one of the highest acts of love for your children.Blair explains how your parasympathetic nervous system — the “rest and digest” network — underpins your mental, physical, and emotional well-being. He emphasizes the vital role of feeling safe, connected, and curious in both health and personal evolution. His advice? Move every hour, sleep according to your chronotype, get sunlight in your eyes first thing in the morning, and start each day with intention. From daily mantras to longevity science from the Buck Institute, Blair's practical wisdom is packed with insights.The conversation also dives into actionable tips for parents on creating resilient, curious, and emotionally stable kids — without overprotecting them. Blair's candid reflection on failure, identity, and the modern health landscape is both refreshing and empowering. Whether you're looking to optimize your body, reconnect with your purpose, or better guide your children in the AI age, this episode delivers.Key TakeawaysChildhood wiring shapes lifelong behaviorSelf-love is essential for effective parentingAuthenticity is the key to a regret-free lifeSafety regulates the parasympathetic nervous systemYour nervous system is the root of health spanFrequent movement trumps long workoutsMorning sunlight resets your biological clockDaily mantras shift your brain's focusSitting is the new smoking — get up hourlyConnection is the #1 longevity multiplierFood is the most important input for your healthKids need a safe place to fail and growRandom acts of kindness heal both giver and receiverLearn More about Blair LaCorte:Websites: https://ppemastermind.com/ https://www.mastermindinnovate.com/ LinkedIn: https://www.linkedin.com/in/blair-lacorte-68084/YouTube: https://www.youtube.com/channel/UCTSlr8fDtSu4Ev_hF6tyqDwBiographical Information on Blair LaCorte:Blair LaCorte is a dynamic business executive who after being raised by two entrepreneurs has taken a path less traveled, unless of course you were Forrest Gump! His career spans numerous industries such as entertainment, aviation, AI, technology, aerospace, consulting, investing and military logistics. Renowned for his insatiable curiosity, collaborative spirit, passionate oratorical skills and competitive drive, Blair consistently strives to make a positive contribution and impact in all his endeavors.For Credibility: Blair has held CEO or “C” level strategy or operating roles in companies such PRG (largest live entertainment production company), XOJET/Vista (largest private aviation company), TPG (one of largest PE firms), Autodesk (largest CAD SW company), and Sun...

If you’re worried about memory loss or have a family history of Alzheimer’s, this episode is a must-listen. Angela sits down with world-renowned neurologist and author Dr. Dale Bredesen to unpack the groundbreaking science behind Alzheimer’s prevention and reversal—even if you carry the APOE4 gene. With over 30 years of research, Dr. Bredesen shares how to optimise your brain health through metabolic flexibility, inflammation control, and personalised interventions. In this powerful and deeply personal episode, Angela also opens up about her own genetic risk and experience caring for her mum with Alzheimer’s. They explore why cognitive decline is not inevitable and how Dr. Bredesen’s new book, The Ageless Brain, is putting the power back into your hands. Whether you're 35 or 75, the steps to preserve your cognition start now—and the tools have never been more accessible. KEY TAKEAWAYS: Alzheimer’s Is Preventable and Reversible: Dr. Bredesen explains how addressing root causes like inflammation, metabolic dysfunction, and toxicity can stop and even reverse cognitive decline. Perimenopause and Brain Fog: Oestrogen loss affects brain energy metabolism, making perimenopausal women more vulnerable to cognitive decline. Your Brain Runs on Supply & Demand: Cognitive health depends on supporting your brain’s high energy needs while reducing inflammatory load and toxic exposure. Check Your Cognitive Biomarkers Early: Blood markers like P-Tau217, GFAP, and A-beta42 can reveal risk decades before symptoms appear. Lifestyle = Medicine: Sleep quality, insulin sensitivity, resistance training, brain stimulation, and even stress reduction all play a critical role. GLP-1s and Alzheimer’s Risk: While popular for weight loss, these drugs may negatively impact cognition in some people—especially APOE4 homozygotes. TIMESTAMPS AND KEY TOPICS:0:00 – Introduction 6:48 – Pathogens, toxins, and the real cause of Alzheimer’s 13:32 – Menopause, oestrogen, and female brain vulnerability 24:05 – Judy’s story: reversing cognitive decline for 13+ years 32:18 – Most common risky behaviours for brain degeneration 42:21 – Best exercises for insulin sensitivity and cognition 51:10 – Supplements that protect brain structure & function 54:22 – How to use The Ageless Brain as a practical guide 58:45 – Final thoughts + where to learn more from Dr. Bredesen VALUABLE RESOURCES Click here for discounts on all the products I personally use and recommend A BIG thank you to our sponsors who make the show possible: Get 20% off the Creatine I love at trycreate.co/ANGELA20, and use code ANGELA20 to save 20% on your firsts order. Brain Boost: Try Neuro Regenerate at lvluphealth.com/angela and use code ANGELA15 to save 15% ABOUT THE GUEST Dale Bredesen, M.D. is an expert in the mechanisms of neurodegenerative diseases such as Alzheimer's disease. He is a graduate of Caltech, and received his MD from Duke University Medical Center. His career has included serving as Chief Resident in Neurology at the University of California, San Francisco, and served as a NIH Postdoctoral Fellow. His faculty position included working at UCSF, UCLA, and the University of California, San Diego. He was the director of the Program on Aging at the Burnham Institute. He was the founding President and CEO of the Buck Institute. He has developed a new therapeutic approach to treating Alzheimer's disease. He is the author of The End of Alzheimer's: The First Program to Prevent and Reverse Cognitive Decline. Dr Dale Bredesen’s latest book: The Ageless Brain: How to Sharpen and Protect Your Mind for a Lifetime - https://amzn.eu/d/gdrjKQm https://www.apollohealthco.com/ https://www.instagram.com/drdalebredesen/ https://www.facebook.com/drdalebredesen/ ABOUT THE HOST Angela Foster is an award winning Nutritionist, Health & Performance Coach, Speaker and Host of the High Performance Health podcast. A former Corporate lawyer turned industry leader in biohacking and health optimisation for women, Angela has been featured in various media including Huff Post, Runners world, The Health Optimisation Summit, BrainTap, The Women’s Biohacking Conference, Livestrong & Natural Health Magazine. Angela is the creator of BioSyncing®️ a blueprint for ambitious entrepreneurial women to biohack their health so they can 10X how they show up in their business and their family without burning out. The High Performance Health Podcast is a top rated global podcast. Each week, Angela brings you a new insight, biohack or high performance habit to help you unlock optimal health, longevity and higher performance. Hit the follow button to make sure you get notified each time Angela releases a new episode. CONTACT DETAILS Instagram Facebook LinkedIn Affiliate Disclaimer: Note this description contains affiliate links that allow you to find the items mentioned in this video and support the channel at no cost to you. While this channel may earn minimal sums when the viewer uses the links, the viewer is under no obligation to use these links. Thank you for supporting the show! Disclaimer: The High Performance Health Podcast is for general information purposes only and do not constitute the practice of professional or coaching advice and no client relationship is formed. The use of information on this podcast, or materials linked from this podcast is at the user's own risk. The content of this podcast is not intended to be a substitute for medical or other professional advice, diagnosis, or treatment. Users should seek the assistance of their medical doctor or other health care professional for before taking any steps to implement any of the items discussed in this podcast. This Podcast has been brought to you by Disruptive Media. https://disruptivemedia.co.uk/

In this episode of Ageless Athlete, we dive into the metabolic engine room with Dr. Brianna Stubbs—world-class endurance athlete and leading researcher at the Buck Institute for Research on Aging. Brianna bridges the worlds of elite performance and cutting-edge science, specializing in how ketones, fasting, and metabolic flexibility can shape our ability to recover, sustain energy, and age well.This isn't about dieting fads or silver bullets—it's about understanding how your body fuels itself, and how those energy pathways evolve over time. Whether you're an endurance athlete or someone simply trying to stay strong into your 40s, 50s, and beyond, Brianna's insights will give you a fresh way to think about performance and longevity.

This week on the WHOOP Podcast, WHOOP Founder and CEO Will Ahmed sits down with WHOOP SVP of Research, Algorithms, and Data Emily Capodilupo to break down an exciting new feature: Healthspan with WHOOP Age and Pace of Aging. Developed in collaboration with the Buck Institute for Research on Aging, WHOOP has created the ultimate longevity metric to understand your physiological age, measuring varying components of sleep, strain, and fitness. Will and Emily introduce the 9 metrics that make up your WHOOP Age and Pace of Aging: sleep consistency, hours of sleep, time in heart rate zones 1-3 and 4-5, strength training, steps, VO₂ Max, resting heart rate, and lean body mass. Healthspan with WHOOP Age and Pace of Aging is now available with WHOOP Peak and WHOOP Life memberships. Healthspan is not available for users under the age of 18.(00:00) What is Healthspan?(8:27) WHOOP Partnership with the Buck Institute(9:30) Why Healthspan? What does WHOOP measure to create this metric? (13:57) WHOOP Age and Pace of Aging (19:16): The 9 Metrics of Healthspan (19:46) Sleep Consistency (23:22) Hours of Sleep(27:28) Time in HR Zones 1-3 and HR Zones 4-5(31:39) Strength Training(35:31) Steps(38:28) VO₂ Max(41:15) Resting Heart Rate(44:14) Lean Body Mass(45:37) The Healthspan Algorithm(48:28) Heathspan Page & The Health Tab(49:12) Coaching people toward a healthier and longer life Support the showFollow WHOOP: www.whoop.com Trial WHOOP for Free Instagram TikTok X Facebook LinkedIn Follow Will Ahmed: Instagram X LinkedIn Follow Kristen Holmes: Instagram LinkedIn Follow Emily Capodilupo: LinkedIn

BUFFALO, NY — April 29, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 3, on March 20, 2025, titled “Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP).” Researchers, led by first author Sudipta Bar and corresponding authors Amit Sharma and Pankaj Kapahi from the Buck Institute for Research on Aging, have found that the enzyme ADAM19 plays an important role in regulating aging in cells and inflammation in the gut. Their study shows that blocking ADAM19 reduced gut damage and inflammation in fruit flies, mice, and human cells. This discovery points to a new possible way to treat gut disorders related to aging by reducing the harmful signals from senescent (aging) cells. As individuals age, DNA damage can lead to the accumulation of senescent cells, contributing to tissue damage. These are cells that stop dividing and release harmful inflammatory substances called the senescence-associated secretory phenotype (SASP). In this study, researchers used fruit flies to search for genes involved in radiation-related gut damage. They identified a gene called meltrin, which is similar to human ADAM19. When meltrin was turned off, the flies had less gut leakage, less inflammation, and fewer signs of cellular aging. “Through an unbiased genome-wide association study (GWAS) utilizing 156 strains from the Drosophila Genetic Reference Panel (DGRP), we identified meltrin (the drosophila orthologue of mammalian ADAM19) as a potential modulator of the senescence-associated secretory phenotype (SASP).” To test if these results applied beyond flies, the team inhibited ADAM19 in mice using a drug called batimastat. Mice treated with the drug after chemotherapy exposure had stronger gut barriers and lower levels of inflammatory markers. The findings extended to human cell cultures, where ADAM19 inhibition reduced signs of cellular aging, including the expression of SASP proteins and β-galactosidase, a classic aging marker. Importantly, this approach does not kill aging cells like many 'senolytic' therapies but instead reduces the harmful substances they release, making it a potential "senomorphic" strategy. The study also showed that ADAM19 helps release certain SASP proteins by cutting them at the cell surface, suggesting a direct role in regulating inflammatory signals. Through proteomic analysis, the team identified 12 SASP proteins that were significantly reduced when ADAM19 was blocked. Many of these proteins are linked to inflammation, immune response, and tissue remodeling in diseases such as inflammatory bowel disease and Crohn's disease. This connection underlines the relevance of the findings for treating chronic gut disorders in aging populations. By targeting ADAM19, researchers may have found a new way to protect gut health and lower inflammation caused by aging cells. This study offers a promising path for creating treatments that maintain healthy tissues without having to destroy aging cells, which could benefit people with gut damage related to aging or medical treatments. DOI - https://doi.org/10.18632/aging.206224 Corresponding authors - Amit Sharma - amit.sharma@sens.org, and Pankaj Kapahi - pkapahi@buckinstitute.org Video short - https://www.youtube.com/watch?v=dRfxQ20O2fQ Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts To learn more about the journal, please visit our website at https://www.Aging-US.com​​. MEDIA@IMPACTJOURNALS.COM

Entrepreneurship and Longevity aren't often discussed in the same sentence, but that's exactly where the future of high-performance leadership is headed. In a time when business moves faster than ever and disruption is the norm, those who sustain success aren't just building companies—they're building resilience from the inside out. Blair LaCorte, Managing Director of LaCorte Ventures, brings a rare perspective on what it takes to lead over the long term. His career spans executive roles across aerospace, artificial intelligence, tech, entertainment, defense, and private equity. From startup growth to IPOs and complex mergers, LaCorte has not only built companies—he's rebuilt them, restructured them, and prepared them for sustainable scalability. It's this unique lens that positions him as a standout voice in the intersection of entrepreneurship and longevity. LaCorte's approach to leadership is rooted in operational excellence, but it's also deeply informed by neuroscience, systems thinking, and human performance. He doesn't just advise organizations—he helps rewire how leaders think about health, decision-making, and the environments they operate in. The topic of longevity often focuses on lifespan. LaCorte challenges that by shifting the conversation to healthspan—how long a leader can operate at their peak, not just how long they live. For entrepreneurs, executives, and founders constantly managing pressure, stress, and uncertainty, this distinction is critical. Peak performance isn't about grinding harder. It's about creating a foundation that allows for clarity, recovery, and sustainability. Throughout his career, LaCorte has worked with over 100 companies as an investor, board member, and adviser. His experience includes leading major transformations and pioneering innovation in fields that rarely cross paths—an advantage he attributes to his curiosity and pattern recognition across industries. From co-founding mastermind networks to helping companies navigate explosive growth, his perspective on entrepreneurship and longevity is not theoretical—it's hard-earned. What sets LaCorte apart is his commitment to systems-level thinking. He views business as a sport—one that demands preparation, precision, and performance, but also recovery, connection, and alignment. His emphasis on building value-based teams, fostering deep connections, and operating with authenticity isn't just cultural advice—it's a competitive edge. This mindset extends into how LaCorte advises leaders to manage themselves. It's not just about productivity hacks or strategic frameworks. It's about building internal infrastructure—mental, emotional, and physical—that allows leaders to make better decisions, manage complexity, and stay adaptable over time. Entrepreneurship and longevity, in his view, are inextricably linked. Without personal optimization, professional growth eventually hits a ceiling. LaCorte's leadership philosophy also underscores the power of community. He's a firm believer in the role of masterminds, not just as a tool for knowledge exchange, but as a critical piece of human connection. In an age of information overload, it's not about accessing more data—it's about curating the right voices, having trusted peers who challenge your assumptions, and staying accountable to continuous growth. His work in launching the Pinnacle Performers Elite Mastermind reflects this belief. By bringing together leaders from diverse industries, LaCorte facilitates a space where pattern recognition, vulnerability, and innovation intersect. These environments are engineered for growth—not just in revenue, but in mindset and mission. The conversation around entrepreneurship and longevity is only becoming more urgent. As business leaders face rising demands and ever-faster innovation cycles, the ones who thrive will be those who build with endurance in mind. It's no longer enough to scale fast. It's about scaling with intention, clarity, and care—for your business, your people, and yourself. Blair LaCorte is part of a new wave of business thinkers who recognize that long-term impact doesn't come from burnout. It comes from balance, recovery, and relentless alignment to purpose. He's lived it, led it, and continues to guide others to do the same. Watch the full episode on YouTube. Don't miss future episodes that feature powerful conversations and actionable insights from today's top business minds. Join Fordify LIVE! Every Wednesday at 11AM Central on your favorite social platforms and catch The Business Growth Show Podcast every Thursday for a weekly dose of business growth wisdom. About Blair LaCorte Blair LaCorte is a transformational leader, entrepreneur, and strategic advisor with a career that spans executive roles across aerospace, AI, tech, defense, entertainment, and private equity. As the Managing Director of LaCorte Ventures, he brings decades of experience guiding companies through rapid growth, operational restructuring, mergers, IPOs, and strategic exits. With a passion for leadership, longevity, and elite performance, Blair is known for applying cross-industry insights to solve complex business challenges. He has served as an investor or advisor to more than 100 companies, helping executive teams unlock growth and build scalable, sustainable strategies. His leadership style combines high-level strategy with a deep understanding of human behavior, systems thinking, and culture. Blair has been recognized as a NASA Innovator of the Year and is a scheduled Virgin Galactic astronaut. He also serves as Vice Chair of the Buck Institute for Research on Aging, where he helps advance science-based approaches to optimizing healthspan and vitality. As the founder of Pinnacle Performers Elite (PPE) Mastermind and MastermindInnovate.com, Blair curates high-impact environments for top-tier entrepreneurs and business owners to connect, grow, and lead with clarity. To explore Blair's latest work in leadership, longevity, and high-performance strategy, visit MastermindInnovate.com for thought leadership and resources, and PPEMastermind.com to learn more about his exclusive mastermind community for elite entrepreneurs. About Ford Saeks Ford Saeks is a Business Growth Accelerator who has helped generate over a billion dollars in sales for organizations ranging from startups to Fortune 500s. With more than 20 years of experience, he's redefined what it means to drive success—combining strategic marketing, innovation, and real-world business acumen. As the President and CEO of Prime Concepts Group, Inc., Ford helps businesses attract loyal customers, expand brand visibility, and improve performance at every level. He's founded over ten companies, authored five books, earned three U.S. patents, and received numerous industry accolades for his work in marketing, leadership, and entrepreneurship. A trailblazer in digital innovation, Ford is also an expert in AI prompt engineering, training businesses to use tools like ChatGPT to create high-impact content and elevate customer engagement. He recently shared his expertise on stage at the “Unleash AI for Business Summit,” where he spoke on the role of AI in transforming operations, marketing, and the customer experience. To learn more, visit ProfitRichResults.com and watch his business TV show at Fordify.tv.

In this episode, I'm joined by Dr. Dale Bredesen, a true pioneer in Alzheimer's research and functional medicine. Together, we dive into groundbreaking advancements in the world of neurodegenerative diseases, with a special focus on the exciting breakthroughs in detecting and potentially reversing Alzheimer's and other related conditions. Dr. Bredesen sheds light on the new disease mechanisms and innovative blood tests that are changing the game, showing us that cognitive decline isn't something we simply have to accept. We also explore his integrative approach to combating Alzheimer's, which includes lifestyle modifications, early detection, and a holistic strategy for better brain health. This conversation is packed with hope and real strategies for a future where Alzheimer's doesn't have to be inevitable. Key Takeaways: New Era of Research: Alzheimer's and similar neurodegenerative diseases are not death sentences, thanks to innovative research and new treatment protocols that emphasize early detection and intervention. Significance of Gut Health: Investigations reveal that gut microbiota and inflammation are crucial risk factors in cognitive decline, underscoring the importance of gut health in preventing Alzheimer's. Role of Lifestyle Changes: Diet, exercise, sleep, and stress management are integral to maintaining brain health and can significantly influence the progression of neurodegenerative diseases. Advance in Diagnostics: Cutting-edge blood tests such as P Tau217 and brain scans can detect early signs of Alzheimer's up to 20 years prior to diagnosis, offering opportunities for preemptive action. The Power of Personalized Medicine: Individualized protocols based on genetic testing, like assessing APOE status, are pivotal in developing effective prevention and treatment strategies for cognitive disorders. More About Dr. Dale Bredesen: Dr. Dale Bredesen, M.D., is a globally recognized expert in neurodegenerative diseases, particularly Alzheimer's disease. With a background that includes graduating from Caltech and earning his M.D. from Duke University Medical Center, Dr. Bredesen's career is marked by groundbreaking research and clinical expertise. He completed his residency as chief resident in neurology at UCSF and further honed his skills at Nobel laureate Stanley Prusiner's lab at UCSF as an NIH postdoctoral fellow. Dr. Bredesen's academic career includes faculty positions at prestigious institutions like UCSF, UCLA, and UC San Diego. As the founding president and CEO of the Buck Institute for Research on Aging, he spearheaded pioneering work in the study of aging and neurodegenerative diseases. Currently, he serves as the chief medical officer of MPI Cognition, where he continues his innovative research and efforts to combat Alzheimer's and related conditions. Dr. Bredesen's expertise and leadership have made him a key figure in the field, with a focus on integrative approaches to prevent and reverse cognitive decline. His contributions are reshaping our understanding of neurodegenerative diseases, offering new hope for those affected by them. Website Instagram Take a Cognitive Assessment here: https://www.apollohealthco.com/know-your-cq/ Get a brain scan: https://getabrainscan.com/ KetoFLEX 12/3: https://www.trifectanutrition.com/apollohealthpartner Connect with me! Website Instagram Facebook YouTube   This episode is sponsored by Professional Co-op®, where clinicians gain exceptional access to industry-leading lab services without the hefty price tag—since 2001, they've been redefining what efficient, patient-focused support looks like. Imagine no hidden fees, no minimums, and only paying for completed tests. Experience lab services that not only meet but also exceed your expectations. Join the co-op trusted by countless licensed clinicians nationwide. Visit www.professionalco-op.com to learn more! This episode is also made possible by Functional Medicine University. FMU is a fully online, self-paced training program in functional medicine, founded in 2006 by Dr. Ron Grisanti. With students in all 50 U.S. states and 68 countries globally, FMU has become a cornerstone in advanced clinical education for healthcare practitioners. The curriculum is led by Dr. Grisanti, alongside contributions from over 70 distinguished medical experts on FMU's advisory board. Graduates earn the prestigious Certified Functional Medicine Practitioner (CFMP®) credential upon completion. FMU is also a nationally approved provider of continuing education for a wide range of licensed professionals, including MDs, DCs, DOs, NDs, acupuncturists, PAs, NPs, nurses, dietitians, pharmacists, and dentists. Whether you're looking to expand your clinical knowledge or bring a functional approach to your practice, FMU offers the tools, guidance, and certification to help you thrive. Visit www.functionalmedicineuniversity.com to learn more!

NextMed Health in a healthtech and biotech conference exploring the most forward thinking ideas and topics in healthcare. Taking place in San Diego, a four day programme covered topics such as latest developments in AI, aging, increasing lifespan and longevity, addressing mental health and exercise through VR, and more. In this special episode of Faces of digital health, Gary Monk and Tjasa Zajc reflect on the key findings through additional discussions with: Anthony Chang, MD, MBA, MPH, Founder, AIMed. Chief Intelligence & Innovation Office, Children's Hospital of Orange County  Daniel Kraft, MD,  Founder & Chair, NextMed Health. Bayo Curry-Winchell, MD, Founder, Beyond Clinical Walls. Urgent Care Medical Director, Saint Mary's Health Network Steven Brown, AI developer, Coder, founder, investor, filmmaker Jennifer Garrison, PhD, Professor, Buck Institute. Co-Founder & Director, ProductiveHealth.org Eric Topol, MD,  Founder and Director, Scripps Research Translational Institute What's covered:

Send us a textIn this episode of the Hotflash inc Podcast, GenX journalist Ann Marie McQueen sits down with Dr Deena Emera, an evolutionary geneticist, senior scientist at the Buck Institute's Buck Center for Healthy Aging in Women, and author of A Brief History of the Female Body: An Evolutionary Look at How and Why the Female Form Came to Be.Dr Emera's research focuses on the genetic basis of reproductive longevity in mammals, and in this fascinating discussion, she breaks down the evolution of menopause, why female bodies age the way they do, and what modern science is uncovering about ovarian health and longevity.If you've ever wondered why menopause exists, how it evolved, and whether science will ever be able to delay or even prevent it, this episode is for you.Highlights: Understanding evolutionary biology (it's not boring, promise)The evolutionary mystery of menopauseWhat animals do go through menopause?Why all women didn't used to die at 50 (and what actually happened)How modern life has changed menopauseWhy Dr Emera needs bowhead whale ovariesCan we really end menopause?The truth about the Grandmother HypothesisQuote:"Menopause itself isn't surprising – if you live long enough, you will run out of eggs. What's unique about humans is that we have such a long post-reproductive life stage. That's the real mystery we need to solve." – Dr Deena EmeraWhere to find Dr Emera:Instagram: @deenaemeraLinkedIn: Deena EmeraBuy her book: A Brief History of the Female Body – Available on AmazonThank you to our sponsor Timeline Nutrition Mitopure supports cellular energy and longevity—now available with a 10% discount! Visit timeline.com/HOTFLASH and use the code HOTFLASH to claim your offer!DisclaimerThis podcast is for informational purposes only and is not intended as medical advice. Always consult your healthcare provider before making any health-related decisions.Join the Hotflash inc perimenoposse: Web: hotflashinc.comNewsletter: Hotflash inc. on SubstackTikTok: @hotflashincInstagram: @hotflashincX: @hotflashinc Episode website: Hotflashinc Listen on: Apple Podcasts | Spotify | Google Podcasts | YouTube | Substack See hotflashinc.com/privacy-policy for privacy information

Your brain isn't just wired—it's mapped biochemically, and those signals may hold the key to longevity. In this episode, Dr. Graham Taylor sits down with Dr. Jennifer Garrison, a leading researcher at the Buck Institute for Research on Aging and an adjunct assistant professor of gerontology. Dr. Garrison's groundbreaking work focuses on neuropeptides—the brain's chemical messengers—and their powerful influence on aging, behavior, and reproductive decline. Using cutting-edge techniques, she investigates how neuropeptide shifts impact longevity and explores the intricate brain-ovary connection, a key yet often overlooked factor in women's health. A recipient of prestigious honors, including the Alfred P. Sloan Research Fellowship, Dr. Garrison is at the forefront of research aimed at unlocking new interventions for age-related conditions. Join us as we dive into her pioneering discoveries and discuss how understanding these biochemical signals could transform our approach to aging—especially for women's health and longevity.   For more information about Dr. Jennifer Garrison and Garrison Lab, please visit: https://garrisonlab.com For more information about Productive Health and the Productive Health Global Consortium, please visit: https://gcrle.org If you would like to support the Global Consortium for Reproductive Longevity and Equality, please consider donating: https://secure.qgiv.com/for/centerforhealthyaginginwomen/ Connect with Buck Institute for Research on Aging on Instagram at: https://www.instagram.com/buckinstituteforaging/ Connect with Buck Institute for Research on Aging on Linkedin at: https://www.linkedin.com/company/buck-institute-for-research-on-aging/ Connect with Buck Institute for Research on Aging on YouTube at: https://www.youtube.com/channel/UClKDVsCWOcAxUXgVyaIGVdw

Aging Research in Women takes center stage as Dr. Jennifer Garrison uncovers the overlooked reality that ovaries age faster than any other organ. This rapid aging, occurring at a rate two and a half times quicker than other tissues, significantly impacts women's health spans. From heightened cardiovascular risks to osteoporosis, the consequences of accelerated ovarian aging are vast, especially post-menopause. Yet, ovarian health research has long suffered from severe underfunding. At the Buck Institute for Research on Aging, Garrison's work aims to address this deficit by understanding the brain-ovary signaling axis, which she believes is key to promoting healthier aging for women. Sponsored by Qualia Senolytic: https://qualialife.com/podcastoffer. Use code podcast when you shop Qualia Senolytic for 15% off your order. Get in touch. Instagram: https://www.instagram.com/qualialife. Facebook: https://www.facebook.com/qualialife. Email: support@qualialife.com.

Jennifer Garrison, PhD, is Co-Founder and Director of the Global Consortium for Reproductive Longevity and Equality (GCRLE) and an Assistant Professor at the Buck Institute for Research on Aging. She also holds appointments in the Department of Cellular and Molecular Pharmacology at the University of California, San Francisco (UCSF) and the Leonard Davis School of Gerontology at the University of Southern California (USC). She is a passionate advocate for women's health and is pioneering a new movement to advance science that is focused on female reproductive aging. Her lab studies the role of mind-body communication in systemic aging, and how changes in the conversation between the ovary and brain during aging may lead to the onset of reproductive decline in females.About Foresight InstituteForesight Institute is a research organization and non-profit that supports the beneficial development of high-impact technologies. Since our founding in 1987 on a vision of guiding powerful technologies, we have continued to evolve into a many-armed organization that focuses on several fields of science and technology that are too ambitious for legacy institutions to support.Allison DuettmannThe President and CEO of Foresight Institute, Allison Duettmann directs the Intelligent Cooperation, Molecular Machines, Biotech & Health Extension, Neurotech, and Space Programs, alongside Fellowships, Prizes, and Tech Trees. She has also been pivotal in co-initiating the Longevity Prize, pioneering initiatives like Existentialhope.com, and contributing to notable works like "Superintelligence: Coordination & Strategy" and "Gaming the Future".Get Involved with Foresight:Apply to our virtual technical seminars Join our in-person events and workshops Donate: Support Our Work – If you enjoy what we do, please consider this, as we are entirely funded by your donations!Follow Us: Twitter | Facebook | LinkedInNote: Explore every word spoken on this podcast through Fathom.fm, an innovative podcast search engine. Hosted on Acast. See acast.com/privacy for more information.

In this episode, Andrea Donsky, a nutritionist, menopause educator, published menopause researcher, and co-founder of WeAreMorphous.com, interviews Dr. Bredesen, the founding president of the Buck Institute for Research on Aging; he has published over 230 papers and achieved the first reversal of cognitive decline in Alzheimer's patients using a precision medicine protocol. Together, they explore cognitive health during perimenopause and menopause with Dr. Dale Bredesen, a pioneering expert in neurodegenerative diseases.Key Topics:Understanding cognitive changes during perimenopause and menopauseThe revolutionary Brain Scan Blood Test for cognitive profilingHow bioidentical hormone therapy (BHRT), nutrition, exercise, and sleep impact brain healthThe connection between dental health and brain microbiomeImpact of toxins on cognitive declineThe role of genetics (APOE states) in cognitionDeep sleep's importance for detoxing the glymphatic systemUnderstanding Heart Rate Variability (HRV) and stress managementResources Mentioned:Dr. Bredesen's RECODE Program: https://training.apollohealthco.com/courses/ReCODE-2-0 (Use code: MENOPAUSE200)Brain Scan Test: https://www.apollohealthco.com/brainscan/Free Cognitive Quotient Test: https://www.apollohealthco.com/know-your-cq-free/APOE Information: https://www.apoe4.info/Send us a text ✅ Fill out our surveys Support our SPONSORS: Qualia https://bit.ly/42mtvmx CODE MORPHUS15 BEAM Minerals https://bit.ly/41DCG1w Code MORPHUS EnergyBits https://bit.ly/49f05YV Code MORPHUS Livon: https://bit.ly/3EjrcGG CODE MORPHUS Order 1 carton of Lypo-Spheric® Vitamin C at LivOnLabs.com & get 1 carton of B Complex Plus FREE ($56 value) just by adding both products to the cart Timeline: timeline.com/morphus CODE MORPHUS

In this episode of 'The Wisdom Of' Show, host Simon Bowen explores groundbreaking research on Alzheimer's disease with Dr. Dale Bredesen, renowned neurodegenerative scientist and CEO of the Buck Institute for Age Research. From challenging medical paradigms to developing revolutionary treatments, Dr. Bredesen shares crucial insights on preventing and reversing neurodegenerative diseases, along with valuable lessons on innovation and resilience in the face of established opposition.Ready to unlock your leadership potential and drive real change? Join Simon's exclusive masterclass on The Models Method. Learn how to articulate your unique value and create scalable impact: https://thesimonbowen.com/masterclassEpisode Breakdown 00:00 Introduction and background 05:13 Challenging conventional wisdom on Alzheimer's 10:46 The 30-year research journey 18:58 Key biomarkers and prevention strategies 25:44 Common contributors to neurodegeneration 33:44 Facing opposition in scientific community 38:35 Balancing hope with reality 45:13 Future implications and conclusionAbout Dr. Dale Bredesen Dr. Dale Bredesen is a pioneer in neurodegenerative disease research and CEO of the Buck Institute for Age Research. With over 30 years of research experience and 200+ peer-reviewed papers, he has revolutionized our understanding of Alzheimer's disease. His groundbreaking work through the ReCODE Protocol™ has demonstrated that neurodegenerative diseases are not only preventable but potentially reversible. As a prodigious innovator in medicine with numerous patents, Dr. Bredesen's research has shifted scientific consensus from viewing these conditions as inevitable to treating them as optional and manageable diseases.Through his work at the Buck Institute For Age Research and Apollo Health, Dr. Bredesen continues to advance our understanding of neurological health while helping patients achieve unprecedented recovery from cognitive decline. His dedication to challenging established medical paradigms has opened new possibilities for treating and preventing neurodegenerative diseases.Connect with Dr. Dale BredesenFacebook: https://www.facebook.com/drdalebredesen/LinkedIn: https://www.linkedin.com/in/dale-bredesen-2ab0651/Instagram: https://www.instagram.com/drdalebredesen/Twitter: https://twitter.com/DrDaleBredesenWebsite: https://www.apollohealthco.com/dr-bredesen/About Simon Bowen Simon has spent over two decades working with influential leaders across complex industries. His focus is on elevating thinking in organizations, recognizing that success is directly proportional to the quality of thinking and ideas within a business. Simon leads the renaissance of thinking through his work with global leaders and organizations.Connect with SimonLinkedIn: https://www.linkedin.com/in/simonbowen-mm/Instagram: https://www.instagram.com/officialsimonbowen/Website:

How do we create schools where students actually want to learn? Meet Kapono Ciotti, an educator working to transform schools from teacher-centered stages to student-led learning environments. Drawing from his experiences in progressive education systems, Ciotti shares practical strategies for letting students take the lead in their learning journey. His innovative approaches and the What School Could Be framework offer a roadmap for educators ready to trust students with real ownership of their education.IN THIS EPISODE, WE DISCUSS:The shift from industrial-age schooling to student-led learningBuilding genuine learning communities in schoolsThe role of AI in transforming educationCreating schools where students want to beNew frameworks for measuring educational successRESOURCES AND LINKS MENTIONED IN THIS EPISODE:Connect with Kapono and What Schools Could Be on LinkedIn, Instagram, the WSCB community, and by visiting www.whatschoolscouldbe.orgWhat Decade Is Your School Preparing Students For? Take the survey and find out: www.whatschoolcouldbe.org/surveyVisit www.principledlearning.org to learn more about Jennifer D. Klein and her workLearn more about the Rebel Project Literacy Curriculum, a fully integrated literacy and project based learning curriculum, at  projectup.us or inkwire.co/rplc Get your copy of Rebel Educator: Create Classrooms Where Impact and Imagination MeetLearn more about Rebel Educator, explore our professional development opportunities for educators and students, and check out our project library.Visit us at UP Academy to learn more about our personalized and inclusive learning environment.Connect with Tanya and UP Academy on LinkedIn, Facebook, and Instagram and learn more about her journey here.GUEST BIO:Kapono Ciotti attributes his educational philosophy to his own schooling experience in a progressive, social-constructivist school during his early years in Honolulu, Hawaii. He taught in Honolulu, Hawaii, and Dakar, Senegal, for over a decade before moving into school leadership. Kapono has led schools in the United States and Egypt, where he put into practice the philosophy of "students making the world a better place," shifting school culture to impact-based education practice. His strong belief in education being an act of social justice drives his work.Kapono has worked internationally in educational change organizations, leading the work of Deeper Learning and place and culture-based pedagogy, and he is currently the Executive Director for What School Could Be. In these roles, he has trained teachers in over 100 schools and school districts over four continents, impacting hundreds of thousands of students. In addition, Kapono spent 15 years as National Faculty for the National Association of Independent Schools in Diversity, Equity, Inclusion, and Justice, facilitating national and international learning experiences. As a curriculum writer, he has authored multiple curricula for federal and non-profit programs. His work has significantly contributed to the organizations What School Could Be, The Buck Institute, EdLeader21, The Pacific American Foundation, and many others.Kapono holds a Ph.D. in International Education Leadership from Northcentral University, a Masters degree in Social Change and Development from the University of Newcastle, and a Bachelors of Language and Culture from the Evergreen State College. He currently lives between Hawaii, Cairo, Egypt, and Dakar Senegal.Enjoying the show? Leave us a rating and review and help more people find us!bit.ly/RebelEducatorApplePodcastsWe'd love it if you could take a few minutes to fill out this survey to let us know how we can bring you the best possible content: forms.gle/JcKHf9DHTZnYUmQr6 Interested in being on the Rebel Educator podcast? Fill out this form and we'll reach out to you if we think you'd be a great fit for an upcoming episode. https://forms.gle/CZJXLQDdevPh22ZN7Want to learn more about opening your own UP Academy? Check out the Rebel Educator Accelerator:www.rebeleducator.com/courses/the-acceleratorMORE ABOUT THE REBEL EDUCATOR PODCAST:In each episode of the Rebel Educator podcast, I deconstruct world-class educators, students, and thought leaders in education to extract the tactics, tools, and routines that you can use as teachers and parents. Join me as we discuss how to shift the classroom, the learning environment, the mindset, and the pedagogy, to resist tradition, reignite wonder, and re-imagine the future of education.This podcast is dedicated to all of the educators who work thankless hours to make our next generation the best it can be.  It was designed to begin conversations on how we can redesign education for the future of work and the success of our students.  It is meant for teachers, students, administrators, homeschoolers and anyone who interacts with and teaches youth. Ready to Turn Your Expertise into a Business?Don't miss Educator 2 Entrepreneur (E2E), a groundbreaking course by my friend, Anthony Kim -  3x successful founder, bestselling author, and education thought leader.E2E is specifically designed for educators ready to make the leap into entrepreneurship, even without startup capital or traditional business experience. Through 20 action-packed lessons across 5 modules, you'll master Anthony's proven framework to build a thriving and sustainable education business.Learn more here:  https://www.educator2entrepreneur.org/a/2148024700/NbhcSHYvWe're thrilled to be sponsored by IXL. IXL's comprehensive teaching and learning platform for math, language arts, science, and social studies is accelerating achievement in 95 of the top 100 U.S. school districts. Loved by teachers and backed by independent research from Johns Hopkins University, IXL can help you do the following and more:Simplify and streamline technologySave teachers' timeReliably meet Tier 1 standardsImprove student performance on state assessments

Blair shares his unique journey into the tech industry, the evolution of technology from hardware to AI, and offers valuable advice for entrepreneurs. He also discusses the innovative work being done at the Buck Institute in the field of longevity and how AI is transforming healthcare and personalized medicine. Follow Blair on LinkedIn The Buck Institute: https://www.buckinstitute.org/ Get on the AI Box Waitlist: ⁠⁠https://AIBox.ai/⁠⁠ Join my AI Hustle Community: https://www.skool.com/aihustle/about 00:00 Introduction to Blair LeCorte and His Journey 05:58 The Evolution of Technology: From Hardware to AI 11:58 Advice for Tech Entrepreneurs 16:02 The Buck Institute and Innovations in Longevity 21:54 The Shift from Illness Treatment to Prevention 28:06 Personalized Health: The Role of Data 41:44 Practical Steps for Longevity and Wellness AI Chat YouTube Channel: https://www.youtube.com/@JaedenSchafer My Podcast Course: https://podcaststudio.com/courses/ Get on the AI Box Waitlist: ⁠⁠https://AIBox.ai/⁠⁠ Join my AI Hustle Community: https://www.skool.com/aihustle/about

Trevor Muir, an inspiring keynote speaker who celebrated the power of storytelling in education and an avid Harry Potter fan, sits down with host Kevin Stoller and co-host Carla Cummins to dive into the real-world connections between education and the beloved book series. They explore the different teaching styles depicted in Harry Potter and the Sorcerer's Stone, the importance of building strong relationships with students, and how elements of the wizarding world can inform and inspire today's learning environments. At last year's LearningSCAPES conference, we had the pleasure of connecting with Trevor Muir, an inspiring keynote speaker who celebrated the power of storytelling in education. His keynote emphasized how authentic engagement empowers students, even through challenging times, by integrating real-world projects. From screening interviews with WWII veterans to creating helpful guides for recent immigrants, his approach demonstrated the impact of learning beyond the classroom. Now, we just need to provide agile spaces to support this type of transformative learning. Tune in to this magical conversation as we explore how the world of Harry Potter can inspire real-world educational practices.   Takeaways: Everyone has their own superpowers It's important to be intentional when sorting students Caring for your students is one of the most impactful things you can do     About Trevor Muir: Trevor is a teacher, author, creator, and co-founder of the New Teacher Academy. His books The Epic Classroom, The Collaborative Classroom, and New Teacher Mindset have helped teachers worldwide to create purposeful and dynamic learning experiences. Trevor has taught in middle, high school, and college classrooms, as well as pre-service teachers at Grand Valley State University. He was a national faculty member for the Buck Institute for Education and his work has been featured in the Huffington Post, Edutopia, EdWeek, and WeAreTeachers. Trevor's inspiring and informative videos have been viewed over 30 million times. At the heart of Trevor's work is the conviction that every student has the potential for greatness, and that every teacher can be equipped to unlock that potential.   Connect with Trevor Muir: Website: https://www.trevormuir.com/ Instagram: https://www.instagram.com/theepicclassroom Twitter: https://x.com/TrevorMuir Facebook: https://www.facebook.com/epicclassroom/ YouTube: https://www.youtube.com/c/TrevorMuir   Connect with co-host, Carla Cummins: LinkedIn: https://www.linkedin.com/in/carla-cummins-01449659/   Connect with host, Kevin Stoller: LinkedIn: https://www.linkedin.com/in/kevinstoller/     Episode 217 of the Better Learning Podcast Kevin Stoller is the host of the Better Learning Podcast and Co-Founder of Kay-Twelve, a national leader for educational furniture. Learn more about creating better learning environments at www.Kay-Twelve.com.     For more information on our partners: Association for Learning Environments (A4LE) - https://www.a4le.org/ Education Leaders' Organization - https://www.ed-leaders.org/ Second Class Foundation - https://secondclassfoundation.org/ EDmarket - https://www.edmarket.org/ Catapult @ Penn GSE - https://catapult.gse.upenn.edu/ Want to be a Guest Speaker? Request on our website

Blair LaCorte is a dynamic business executive who after being raised by two entrepreneurs has taken a path less traveled, unless of course you were Forrest Gump! Blair has held CEO or “C” level strategy or operating roles in companies such PRG (largest live entertainment production company), XOJET/Vista (largest private aviation company), TPG (one of largest PE firms), Autodesk (largest CAD SW company), and Sun Microsystems / Oracle (largest workstation HW company). In addition, Blair has taken several companies from start up to IPO such as AEye Technologies (1.5b IPO in 2021) and VerticalNet (#1 IPO in 1999). Today, Blair is currently an Astronaut in training for Virgin Galactic where he expects to fly in 2026. Blair is the Vice Chairman of the Buck Institute, the world's leading research organization on longevity and aging as well as Co-Founder and Facilitator of a highly rated Mastermind group of 40 global CEO's. What you will learn The value of self-awareness in achieving personal and professional growth. How adaptability and resilience can lead to unexpected opportunities. Why meaningful relationships are essential for happiness and success. Insights on using AI and technology for health and personalized care. Lessons on balancing career risks, timing, and personal authenticity.

As part of the US HUPO sponsored "Philly Express" series highlighting speakers at the upcoming 2025 US HUPO meeting in Philadelphia, Ben and Ben sit down to talk with Dr. Tara Tracy, Buck Institute for Research on Aging.

What if aging wasn't inevitable, but something you could slow—or even reverse? In this episode of “The Dr. Hyman Show,” Dr. Eric Verdin, the president of the Buck Institute for Research on Aging, and I dive deep into the science of longevity. Discover how lifestyle choices, mitochondrial health, and cutting-edge research are transforming our understanding of aging. From fasting and nutrient sensing to emerging therapies like CD38 inhibitors, this episode reveals actionable insights to help you live a longer, healthier life. In this episode, we discuss: The Role of Mitochondria in Aging The Critical Role of NAD Levels and Aging Lifestyle Interventions for Longevity Gene Therapy The Importance of CD38 and Enzyme Inhibition View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman Sign Up for Dr. Hyman's Weekly Longevity Journal This episode is brought to you by Rupa Health, BIOptimizers, LMNT, and Fatty 15. Streamline your lab orders with Rupa Health. Access more than 3,500 specialty lab tests and register for a FREE live demo at RupaHealth.com. Don't let stress take over your holidays. Try Magnesium Breakthrough from BiOptimizers. Head to Bioptimizers.com/Hyman and use code HYMAN10 to save 10%. LMNT is giving listeners a FREE eight-count sample pack of their vital electrolyte drink mix with any purchase. Just visit DrinkLMNT.com/Hyman today. Fatty15 contains pure, award-winning C15:0 in a bioavailable form. Get an exclusive 15% off a 90-day starter kit subscription. Just visit Fatty15.com and use code DRHYMAN10 to get started. Learn more about your ad choices. Visit megaphone.fm/adchoices

There is a lot of talk about living to the age of 100 or more, but not as much about the threat of age-related disease. Dr. Gordon Lithgow of the Buck Institute, the world's first biomedical research institution devoted to research on aging, believes we can stay healthy as we live longer. It all starts with biology...and worms. Brought to you by NEXTVillageSF.orgNEXT Village SF is a neighborhood nonprofit providing services and support that empowers members to live independently.

In this episode of the Mind Gut Conversation podcast, I speak with Dr. Eric Verdin, one of the world's experts on healthy aging and longevity. Dr. Verdin is president and CEO of the Buck Institute for Research of Aging, the world's only research institution singularly focused on the biology of aging. During this episode, we talk about a number of fascinating topics, including: 1) Besides lifestyle modifications, what are the most promising strategies to increase the health span in humans? 2) What is the reason for the progressive increase in centenarians in different parts of the world? 3) What role do genes play in longevity? Enjoying our podcast? Please leave us a review and any feedback to improve our show!

Dr. David Furman is a key researcher at the Buck Institute for Research on Aging, where he focuses on understanding the underlying mechanisms of aging and chronic diseases, particularly through the lens of the immune system. His research centers around "inflammaging," the concept that low-grade, chronic inflammation contributes to the aging process and the development of age-related diseases like cardiovascular disease, neurodegenerative disorders, and metabolic syndromes. At the Buck Institute, Dr. Furman leads efforts to unravel how immune dysfunction plays a pivotal role in accelerating biological aging. His work integrates systems biology approaches, including advanced computational and bioinformatic tools, to analyze large datasets related to human immunity and inflammation. By understanding how these systems change over time, Dr. Furman aims to identify biomarkers of aging and develop therapeutic strategies to target inflammaging. In addition to his role at the Buck Institute, Dr. Furman is involved in the 1000 Immunomes Project, a large-scale initiative to map the immune systems of individuals across different age groups. This project has contributed significantly to the growing understanding of how the immune system deteriorates with age and how this process may be modifiable through intervention. Dr. Furman's work is influential in the longevity and biotech spaces, and he continues to be a thought leader in the development of anti-inflammatory therapies to extend healthspan and potentially delay the onset of age-related diseases. Timestamps 00:00 Introduction to Inflammation and Longevity 03:06 Understanding Inflammation and Aging 05:52 The Role of Environment in Inflammation 09:14 Ancestral Lifestyle Experiment 12:04 The Importance of Movement and Daily Activity 14:54 Nutrition and Its Impact on Health 18:14 The Future of Aging Research and AI 21:02 The Threat of Microplastics 23:53 Conclusion and Future Directions

Welcome back to Egg Meets Sperm! I'm Dr. Aumatma, and this is the best podcast to get all the vital information you need to support your fertility journey holistically for you and your partner—because fertility takes two.Today, we're joined by Dr. Joseph Antoun, CEO of L-Nutra, the company behind the groundbreaking ProLon Fasting Mimicking Diet. Dr. Antoun's passion is enhancing human longevity, and he's here to share how fasting can impact fertility and support reproductive health.In this fascinating conversation, we dive into:✨ Topics Covered:The science behind different types of fastingHow the Fasting Mimicking Diet promotes cellular rejuvenationThe connection between biological aging and fertilityClinical research on ProLon and its benefits for metabolic healthTips for safely incorporating fasting into your fertility journeyDr. Antoun also shares incredible insights from his impressive background in health policy and aging research, including how fasting can reverse biological age and improve overall vitality.Dr. Joseph Antoun's passion is to enhance Human Longevity. He is the CEO and Chairman of the Board of L-Nutra Inc., a unique Nutrition technology company leading the Longevity and Food as Medicine markets.Before taking on these roles, Dr. Antoun was the CEO of Health Systems Reform, a boutique consultancy aimed at elevating public health through reforming health systems, strengthening healthcare management and improving healthcare delivery; the Co-Director of the Center for Health Policy at the University of Chicago; an adjunct Professor of Health Policy at the Buck Institute for Research on Aging; and a fellow at the Department of Social Policy at the London School of Economics and Political Science. Dr. Antoun founded and served as the Co-Editor in Chief of the Journal of Health Systems and Reform. He served as the Chairman of the Board at the Global Healthspan Policy Institute (GHPI), as member of Forbes Business Development and as head of Business Development for Emerging Markets at Eli Lilly & Company.Dr. Antoun has dedicated his professional experience to launching two novel markets: the first is the Longevity Market whereby he launched the first tested and patented healthy aging product called ProLon. The second is the Food as Medicine market whereby he launched Nutrition for Longevity which is now amongst the first food ever to be reimbursed by CMS and insurances.Dr. Antoun completed his Health Policy studies at Harvard University, Public Health at Johns Hopkins University, Medicine and Biological Sciences at Saint Joseph University, and his PhD studies in Mediterranean & Middle Eastern Studies at King's College. He is married to the loveliest Carine, has three amazing boys and stays healthy by consuming ProLon and walking daily for hours while on his phone.Learn more about Dr. Antoun and ProLon:L-Nutra: https://l-nutra.comProLon Fasting Mimicking Diet: https://prolonfast.comLet's chat! I want to hear from you! Send me a voice memo with:- what you loved- what you want to see improve- any guests you want me to bring on- AND any questions you want me to cover on the podcast!Did you know you can join my private community to support you in getting Fertile As...

In this weeks episode of "Pushing the Limits" , Dr. David Furman, Director of the 1000 immunomes project, the world's largest longitudinal population-based study of immunology and aging at Stanford University and Associate Professor at the Buck Institute for Aging, Founder of Edifice Health and Cosmica Biosciences, discusses his extensive research in immunology, particularly focusing on the 1000 Immunomes Project, which aims to understand the immune system's role in aging.  He emphasizes the importance of studying human biology over traditional animal models and introduces the concept of the Inflammation Age Clock as a new biomarker for aging.  The discussion also covers the implications of systemic chronic inflammation in aging, the role of nutrition, and the potential for interventions to improve health span. Additionally, Dr. Furman shares insights into his work with NASA on accelerated aging in astronauts, highlighting the broader applications of his research in combating age-related diseases.   Takeaways:    Dr. Furman aims to have a massive impact on human health. The immune system plays a crucial role in aging. Human studies provide better insights than animal models. The Inflammation Age Clock is a new biomarker for aging. Chronic inflammation is a key factor in age-related diseases. Nutrition significantly affects inflammation and aging. Reliable biomarkers are needed for effective aging interventions. NASA's research on astronauts reveals accelerated aging in space. The convergence of technologies is revolutionizing health research. Future research will focus on protecting astronauts and advancing aging studies. Titles: System Chronic Inflammation: The Hidden Driver of Aging Nutrition and Inflammation: Key Factors in Health span   About the 1000 immunomes Project: The Stanford 1000 Immunomes Project (KIP) is a collaborative ongoing study at Stanford University that aims to define the biological basis of aging and disease using state-of-the-art 'omics' platforms and advanced artificial intelligence (AI) methods. The main focus of 1KIP is to establish biomarkers for healthy versus sub-functional immune systems. They do this by identifying the interactions between genetic and environmental factors, which contribute to the observed heterogeneity of biological responses in human beings.  To this end, 1000 individuals of different age groups (9-96 years old) were recruited between 2007-2017. Their blood samples were screened using multiple state-of-the-art technologies at a single facility, the Human Immune Monitoring Center (HIMC) to measure circulating proteins, cell types, cellular functions, whole-genome blood gene expression and subjects' haplotypes using deep sequencing technologies. The 1KIP dataset has enabled us for the first time to identify reliable biomarkers of aging and disease in a longitudinal population-based study of immunology and aging. 1KIP provides reference values for thousands of immune variables and identifies clusters of individuals sharing similar health versus disease immune profiles. BIO Dr. David Furman is an academic entrepreneur deeply committed to addressing intricate challenges within human biology, systems medicine, translational immunology, preventative healthcare, aging, and precision longevity. Holding positions as the Director of the Stanford 1000 Immunomes Project at the Stanford School of Medicine and as an Associate Professor and Director of the Bioinformatics and Data Science Core at the Buck Institute for Research on Aging, Dr. Furman leads research endeavors that leverage multi-scale biology ('omics') platforms and advanced AI/ML methodologies. He identifies biomarkers and integrative biological clocks essential for monitoring individual health statuses. Groundbreaking technologies originating from the Furman lab now facilitate the application of descriptive and mechanistic biomarkers to detect and combat accelerated aging and disease progression. With over 15 years of specialization in inflammation's role in aging mechanisms, Dr. Furman's expertise includes various domains, including neuroscience, cardiovascular health, metabolic diseases, and immune system function. Notably, in 2022, NASA's Human Research Program sought Dr. Furman's collaboration, leading to partnerships with SpaceX and Cornell University. Dr. Furman's entrepreneurial initiatives include the founding of the Inflammaging Institute, aimed at democratizing biological aging diagnosis, and the establishment of Stanford spin-off Edifice Health Inc., and Buck Institute spin-off Cosmica Biosciences Inc., both focused on innovative approaches to combat aging-related ailments and precision longevity interventions. Dr. Furman has published over 50 scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others, and is the inventor of over 25 patents.     Personalised Health Optimisation Consulting with Lisa Tamati Lisa offers solution focused coaching sessions to help you find the right answers to your challenges. Topics Lisa can help with:  Lisa is a Genetics Practitioner, Health Optimisation Coach, High Performance and Mindset Coach. She is a qualified Ph360 Epigenetics coach and a clinician with The DNA Company and has done years of research into brain rehabilitation, neurodegenerative diseases and biohacking. She has extensive knowledge on such therapies as hyperbaric oxygen,  intravenous vitamin C, sports performance, functional genomics, Thyroid, Hormones, Cancer and much more. She can assist with all functional medicine testing. Testing Options Comprehensive Thyroid testing DUTCH Hormone testing Adrenal Testing Organic Acid Testing Microbiome Testing Cell Blueprint Testing Epigenetics Testing DNA testing Basic Blood Test analysis Heavy Metals  Nutristat Omega 3 to 6 status and more  Lisa and her functional medicine colleagues in the practice can help you navigate the confusing world of health and medicine . She can also advise on the latest research and where to get help if mainstream medicine hasn't got the answers you are searching for whatever the  challenge you are facing from cancer to gut issues, from depression and anxiety, weight loss issues, from head injuries to burn out to hormone optimisation to the latest in longevity science. Book your consultation with Lisa    Join our Patron program and support the show Pushing the Limits' has been free to air for over 8 years. Providing leading edge information to anyone who needs it. But we need help on our mission.  Please join our patron community and get exclusive member benefits (more to roll out later this year) and support this educational platform for the price of a coffee or two You can join by going to  Lisa's Patron Community Or if you just want to support Lisa with a "coffee" go to  https://www.buymeacoffee.com/LisaT to donate $3   Lisa's Anti-Aging and Longevity Supplements  Lisa has spent years curating a very specialized range of exclusive longevity, health optimizing supplements from leading scientists, researchers and companies all around the world.  This is an unprecedented collection. The stuff Lisa wanted for her family but couldn't get in NZ that's what it's in her range. Lisa is constantly researching and interviewing the top scientists and researchers in the world to get you the best cutting edge supplements to optimize your life.   Subscribe to our popular Youtube channel  with over 600 videos, millions of views, a number of full length documentaries, and much more. You don't want to miss out on all the great content on our Lisa's youtube channel. Youtube   Order Lisa's Books Lisa has published 5 books: Running Hot, Running to Extremes, Relentless, What your oncologist isn't telling you and her latest "Thriving on the Edge"  Check them all out at  https://shop.lisatamati.com/collections/books   Perfect Amino Supplement by Dr David Minkoff Introducing PerfectAmino PerfectAmino is an amino acid supplement that is 99% utilized by the body to make protein. PerfectAmino is 3-6x the protein of other sources with almost no calories. 100% vegan and non-GMO. The coated PerfectAmino tablets are a slightly different shape and have a natural, non-GMO, certified organic vegan coating on them so they will glide down your throat easily. Fully absorbed within 20-30 minutes! No other form of protein comes close to PerfectAminos Listen to the episode with Dr Minkoff here:    Use code "tamati" at checkout to get a 10% discount on any of their devices.   Red Light Therapy: Lisa is a huge fan of Red Light Therapy and runs a Hyperbaric and Red Light Therapy clinic. If you are wanting to get the best products try Flexbeam: A wearable Red Light Device https://recharge.health/product/flexbeam-aff/?ref=A9svb6YLz79r38   Or Try Vielights' advanced Photobiomodulation Devices Vielight brain photobiomodulation devices combine electrical engineering and neuroscience. To find out more about photobiomodulation, current studies underway and already completed and for the devices mentioned in this video go to www.vielight.com and use code “tamati” to get 10% off     Enjoyed This Podcast? If you did, subscribe and share it with your friends! If you enjoyed tuning in, then leave us a review and share this with your family and friends. Have any questions? You can contact my team through email (support@lisatamati.com) or find me on Facebook, Twitter, Instagram and YouTube. For more episode updates, visit my website. You may also tune in on Apple Podcasts.  To pushing the limits, Lisa and team

On this episode of Longevity by Design, Ashley Reaver, MS, RD, CSSD, and Dr. Gil Blander, delve into the intricate world of the immune system and its impact on aging with Dr. David Furman, Associate Professor at the Buck Institute for Research on Aging. David discusses his groundbreaking research on inflammaging— uncovering how chronic, low-grade inflammation can accelerate the aging process. Discover how David's team developed a new inflammatory age test, soon to be available from his company Edifice Health, that uses five key proteins to assess an individual's inflammatory state and predict future health risks. We also explore the surprising link between space travel and accelerated aging, examining the impact of microgravity on the body. Tune in to learn practical tips on combating inflammation and promoting longevity through lifestyle choices and a deeper understanding of your own personal health data.Episode highlights:Introduction: 00:00:00Why have you decided to be a scientist and not a painter: 00:04:001000 Immunomes: 00:06:00What is the immune system: 00:16:00Biomarkers related to the immune system: 00:18:00The development of frailty during the aging process: 00:21:00what inflammation is: 00:27:00Lifestlye dependent chronic stress: 00:31:00Inflammation-related biological clock: 00:34:00Epigenetic age: 00:38:00Centenarians and inflammatory markers: 00:48:00Space flight and inflammation: 00:51:00Astronauts aging: 00:55:00Microgravity as a stressor: 00:59:00Future of David's work: 01:04:00Summary: 01:06:00Not All Biological Age Clocks Are Created EqualWhile various biological age clocks exist, including epigenetic and glycan clocks, David's research highlights the benefits of protein-based clocks like his inflammatory age test. Unlike other clocks that closely correlate with chronological age, inflammatory age reveals more about an individual's biological state and potential health risks, offering valuable insights beyond simply reflecting the passage of time. Additionally, understanding how specific proteins link to inflammation allows for actionable lifestyle and dietary changes to positively impact those markers and potentially slow down the aging process. Lifestyle Choices Directly Impact Our Inflammatory LevelsMany modern lifestyle factors, often a far cry from our evolutionary past, contribute to chronic inflammation. These include exposure to environmental toxins like plastics and pesticides, poor sleep quality, disruptions to our circadian rhythm, social isolation, and chronic stress. By minimizing these exposome factors and adopting healthier habits—such as consuming whole foods, prioritizing sleep hygiene, and managing stress—we can potentially lower inflammation and support healthier aging. Space Travel Offers a Unique Perspective on Accelerated AgingAstronauts, despite being otherwise healthy individuals, experience accelerated aging due to the stressors of space travel, particularly the effects of microgravity. This provides valuable data on aging mechanisms that can be applied to Earth-bound research. By studying the physiological changes astronauts undergo, scientists can gain a deeper understanding of aging processes and potentially develop interventions to mitigate age-related decline for everyone. For science-backed ways to live a healthier longer life, download InsideTracker's Top 5 biomarkers for longevity eBook at insidetracker.com/podcast 

Special THANKS to the episode sponsor Magic Mind! Limited offer: Get up to 48% off your first subscription or 20% off one-time purchases with code   CLAUDIAG20  at checkout.   You can claim it at: https://magicmind.com/claudiag   ------------- EPISODE SUMMARY Join scientist and mindset & high-performance coach Claudia Garbutt and longevity expert Dr. Joseph Antoun, the CEO of L-Nutra as they discuss science-backed strategies for living longer, healthier lives.   In this episode, we talk about: - Fasting & the Fasting Mimicking Diet - Why Intermittent Fasting is not Enough - Best Science-Backed Tips for Promoting Longevity & Healthspan   EPISODE NOTES Dr. Joseph Antoun is a visionary leader and renowned expert in the field of longevity, dedicated to enhancing human healthspan through cutting-edge nutrition technology. As the CEO and Chairman of the Board at L-Nutra for over 7 years, Dr. Antoun is at the forefront of the booming longevity industry. Prolon has sold more than 3M products, has more than 1M customers globally, and backed by $100M in funding and 132+ patents.   Dr. Antoun served as the Chairman of the Board at the Global Healthspan Policy Institute (GHPI) and as a member of Forbes Business Development Council.   Before taking on these roles, Dr. Antoun was the CEO of Health Systems Reform, a boutique consultancy aimed at elevating public health through reforming health systems, strengthening healthcare management and improving healthcare delivery; the Co-Director of the Center for Health Policy at the University of Chicago; an adjunct Professor of Health Policy at the Buck Institute for Research on Aging; and a fellow at the Department of Social Policy at the London School of Economics and Political Science. Dr. Antoun founded and served as the Co-Editor in Chief of the Journal of Health Systems and Reform.   Dr. Antoun has dedicated his professional experience to reforming health systems towards preventive care, to create a market for healthy aging by launching the first aging and longevity product called ProLon, and to bringing back fasting as a longevity practice to humanity. In 2016, Dr. Antoun launched the Fasting Market, which by 2018, became the #1 nutrition regimen in the US, and continues to grow in popularity. In 2018, the Fasting Mimicking Diet was granted a patent on 'promoting longevity and healthspan'.   Dr. Antoun completed his Health Policy studies at Harvard University, Public Health at Johns Hopkins University, Medicine and Biological Sciences at Saint Joseph University, and his PhD studies in Mediterranean & Middle Eastern Studies at King's College.   Links: www.prolonlife.com   https://l-nutra.com/   https://www.instagram.com/prolon/?hl=en    https://www.facebook.com/prolonfmd/   https://www.linkedin.com/in/drjosephantoun/     ------------ Click this link to listen on your favorite podcast player and if you enjoy the show, please leave a rating & review: https://linktr.ee/wiredforsuccess   ------------------   Music credit: Vittoro by Blue Dot Sessions (www.sessions.blue)   -----------------   Disclaimer: Podcast Episodes might contain sponsored content.

In this episode of Longevity by Design, hosts Ashley Reaver and Dr. Gil Blander welcome Dr. Julie Andersen, a distinguished neuroscientist at the Buck Institute for Research on Aging, who discusses her groundbreaking work on neurodegenerative diseases, focusing on Parkinson's and Alzheimer's. She explains how the field of geroscience is transforming our understanding of aging, revealing that common underlying processes in various diseases could lead to universal therapeutic approaches.Dr. Andersen dives into the gut-brain connection, highlighting how gut health significantly impacts brain aging and the progression of neurodegenerative diseases. She also emphasizes the importance of cellular senescence, a process where aging cells stop dividing, contributing to diseases like Alzheimer's. Her research explores innovative ways to slow or prevent these processes, paving the way for new treatments.The episode concludes with Dr. Andersen advocating for lifestyle interventions, particularly exercise, as powerful tools in preventing neurodegenerative diseases. She underscores the potential of personalized medicine in tailoring treatments to individual aging patterns, offering hope for more effective and targeted therapies.Episode highlights:Introduction: 00:00:00Dementia as a side effect of aging: 00:06:00Dementia prevalence in the population: 00:10:00The environment and Alzheimer's disease: 00:15:00Biological sex effect on Dementia 00:17:00Ethnicity effect on Dementia  00:18:00What to expect when you are diagnosed with Dementia 00:19:00Biomarkers for Dementia 00:26:00The connection between the hallmarks of aging and Dementia: 00:30:00 Exercise and Dementia: 00:34:00disruption of REM sleep as an early sign of Parkinson's: 00:37:00What is the current treatment for Parkinson's: 00:38:00Cellular senescence and neurodegenerative diseases: 00:42:00Beta amyloid plaques and Alzheimer's disease: 00:50:00Autophagy and dementia: 01:00:00What would you recommend to a person who like to live better and longer: 01:08:00

In this episode of Longevity by Design, hosts Ashley Reaver and Dr. Gil Blander welcome Dr. Brianna Stubbs, an expert in exogenous ketone metabolism. Dr. Stubbs shares her journey from being a competitive rower to becoming a scientist. She dives into her research on ketone biology and its implications for health and aging.Dr. Stubbs discusses the science behind ketones, explaining how they serve as an alternative fuel for the brain and body, particularly during periods of low carbohydrate intake. She highlights the potential benefits of ketones for cognitive function and heart health, noting their ability to act as signaling metabolites that influence oxidative stress and inflammation.The conversation also explores the practical applications of ketone supplements for athletes and the general public. Dr. Stubbs emphasizes the importance of personalized approaches to diet and supplementation, considering individual goals and health conditions. She provides insights into her ongoing research at the Buck Institute, aiming to translate scientific discoveries into practical tools for healthy aging.

275 Delaying Menopause - Understanding the Ovary Dr. Jennifer Garrison, a researcher and assistant professor at the Buck Institute for Research on Aging, discusses her work on women's health and aging. She explains that her goal is to understand the underlying mechanisms of aging and develop interventions that promote women's health. Dr. Garrison focuses on the role of the hypothalamus, a part of the brain that controls various homeostatic systems in the body, including reproductive function. She emphasizes the importance of studying bioactive peptides, which act as chemical signals between the brain and other tissues. Menopause is defined as the cessation of menstruation for 12 months, but it also coincides with changes in ovarian function and the production of various chemical signals. Dr. Garrison highlights the need for further research to understand ovarian function and develop interventions to extend ovarian health. The conversation explores the work of the Center for Reproductive Longevity and Equality and the importance of maintaining ovarian function for healthy aging in women. The center funds grants to scientists and clinicians studying ovarian aging and has seen significant progress in the field. The discussion also touches on the use of frozen ovarian tissue for preserving fertility in cancer patients and the role of peptides in reproductive function. The conversation emphasizes the need to reframe the narrative around women's health and highlights the inequality in health span between men and women. Takeaways Understanding the underlying mechanisms of aging can lead to interventions that promote women's health. The hypothalamus plays a crucial role in regulating various homeostatic systems in the body, including reproductive function. Bioactive peptides act as chemical signals between the brain and other tissues, influencing various physiological processes. Menopause is defined as the cessation of menstruation for 12 months, but it also involves changes in ovarian function and the production of chemical signals. Further research is needed to understand ovarian function and develop interventions to extend ovarian health. The Center for Reproductive Longevity and Equality funds grants to study ovarian aging and has seen significant progress in the field. Frozen ovarian tissue can be used to preserve fertility in cancer patients. Peptides play a crucial role in reproductive function, but caution should be exercised when using peptide therapies. The narrative about women's health needs to be reframed to focus on maintaining ovarian function for healthy aging. Women live longer than men on average but spend a longer portion of their lives in poor health, highlighting an inequality in health span. https://www.buckinstitute.org/lab/garrison-lab/ https://www.linkedin.com/in/drjennifergarrison/ https://gcrle.org/ Special thanks to our sponsor, SOLV Wellness! To learn more about Ellura by Solv Wellness, visit ellura.com for 30% off your first purchase automatically applied at checkout. For an additional $5 off, use coupon code DRKELLY5. Preorder my book "You Are Not Broken: Stop "Should-ing" All Over You Sex Life" Listen to my Tedx Talk: Why we need adult sex ed Take my NEW Adult Sex Ed Master Class: https://www.kellycaspersonmd.com/adult-sex-ed Join my membership to get these episodes ASAP, a private facebook group to discuss and my private accountability group for your health, hormones and life support! www.kellycaspersonmd.com/membership