Podcasts about Hacking

Evil MSI Background: BASE64 Statistical Analysis https://isc.sans.edu/diary/Evil%20MSI%20Background%3A%20BASE64%20Statistical%20Analysis/33072 Cisco Catalyst SD-WAN Manager Arbitrary File Write Vulnerability https://sec.cloudapps.cisco.com/security/center/content/CiscoSecurityAdvisory/cisco-sa-sdwan-arbfw-c2rZvQ TSME/SME not activating on Ryzen 7 9700X https://github.com/AMDESE/AMDSEV/issues/292 Deep-Research Agents Can Be Poisoned via User-Generated Content https://arxiv.org/pdf/2605.24245 My Upcoming Classes https://www.sans.org/profiles/dr-johannes-ullrich

Atomic Arch: Attackers Hijack Trusted AUR Packages to Deliver Rootkit-Like Malware https://www.sonatype.com/blog/atomic-arch-npm-campaign-adds-malicious-dependency Why Use App-Level Auth When Every Database Has Auth? (Splunk Enterprise CVE-2026-20253 Pre-Auth RCE) https://labs.watchtowr.com/why-use-app-level-auth-when-every-database-has-auth-splunk-enterprise-cve-2026-20253-pre-auth-rce/ A Fake Bug Report Hijacks Your AI Coding Agent and Nothing Catches It. https://tenetsecurity.ai/blog/agentjacking-coding-agents-with-fake-sentry-errors/ My Upcoming Classes https://www.sans.org/profiles/dr-johannes-ullrich

Today, let's talk about how to counter the rapidly evolving cyber threats facing the transportation industry in this episode with Jaime Lightfoot of Lightfoot Labs and Joe Ohr of the NMFTA! They share the new realities of logistical vulnerabilities, moving beyond abstract ransomware fears to reveal how everyday tools like legacy maintenance software and Electronic Logging Devices (ELDs) are being weaponized as backdoors into critical transport infrastructure. They also breaks down why fleets cannot afford to play catch-up with sophisticated, state-sponsored cybercriminals who exploit software white-labeling and GPS spoofing to manipulate logbooks or orchestrate strategic cargo theft. From simple wired connections during routine garage service to complex wireless interventions while trucks are actively moving on the highway, this conversation serves as a wakeup call emphasizing that asset protection requires continuous, proactive defensive remediation and a rigorous evaluation of every digital touchpoint in your supply chain!   About Jamie Lightfoot Jaime Lightfoot is an independent security researcher, electrical engineer, and full-stack developer with over 12 years of industry experience. She specializes in embedded systems security within heavy trucking, automotive, and other critical infrastructure, helping companies assess vulnerabilities and working with their engineers to fix the gaps.    About Joe Ohr Joe Ohr has more than two decades of experience in technical operations, customer success management, customer support, and product support. Currently serving as the Chief Operating Officer for the National Motor Freight Traffic Association, Inc. (NMFTA)™, he plays a pivotal role in helping to advance the industry through digitization, classification, and cybersecurity. Prior to Ohr's role at NMFTA, he served as in numerous engineering and operations positions at Qualcomm and Eaton, and most recently held the position of Senior Vice President of Operations/Customer Experience at Omnitracs. Throughout his career, Ohr has provided strategic guidance, vision, and a roadmap for addressing long-term customer challenges. He has played a key role in accelerating revenue growth and has collaborated closely with IT, product, and engineering teams to foster stronger partnerships with strategic customers and peers. Additionally, Ohr has overseen post sales customer support and service teams, as well as operations, managing a workforce of over 400 individuals. He holds multiple certifications such as CCNA from Cisco and MCSE from Microsoft and earned his Bachelor of Science in Education from the Ohio State University. Due to his contributions to the industry, he earned a spot in the Inner Circle in 2015 and 2018 from Qualcomm and Omnitracs.  

Lords: Erica Krissy Topics: The Battle of Food Dog and Valley Jump Park The Wilson Wolfe Affair, or, how I spent $350 on the mysterious wolfe in the sky This tabletop RPG with scripting support https://mastodon.tomodori.net/@vga256/116246406043573614 Why the heck are we making everything smart these days? And why is the security so terrible (A.K.A. The Lovense Story) The Naming of Cats by T.S. Eliot https://poets.org/poem/naming-cats Microtopics: The first and still only place you can discuss topics. Writing down your plugs ahead of time. The happy ending you deserve. A small child crawling into your bed in the middle of the night and asking the questions that keep him up at night, such as "can you one-shot a Silver Boss Bokoblin with a regular arrow and a Lizal strong bow?" Giving your child a classical education. (In Zelda and Mario games.) Living in Virginia near a bunch of Confederate monuments. Looking at the battle map to see where the soldiers come down from the Food Lion. The monument to not building anything. Sonically-enforced exclusion zones. Whether there's sound in the eye of the hurricane. What they call the Wal-Mart in Puerto Rico. Podcasts on which it's okay to hate the French. Quebecois LARPing as French. History: it's all around us, and it keeps happening. Wanting to spend $350 on the wolf in the sky but the wolf just won't take your money. Simulacra Games. Spinning a zoetrope. Questioning the palness of these supposed pals. Little mom and pop shops exhorting you to solve this unsolved cold case murder. Side stories extending the lore. Applying heat to make the secret message appear, then applying cold to make the message disappear so that the next person can apply heat to make the secret message appear. Being so busy making your video game that you don't have the spare energy to solve an interesting puzzle. Kitchen table ARGs. Dang you, Mr. Stormdancer! Always coming up with your schemes. What happened to the Twinbeard corporation. Paying $800 a year in something something taxes to keep your corporation going. Incorporating in the state of Delaware. Licensing the Frog Fractions brand for a dollar. Retiring and making Pico-8 games for the rest of your life. It's like PiCoSteveMo all year! Reading your program aloud to the DM who executes it in his head. Reading your program aloud to the DM who tells you there's a syntax error on line 397. Writing out a program to present to the class. You went over my helmet?! Programming in Logo and watching the turtle move around the screen. Rehabilitating the image of Lisp-like languages by changing the parentheses to square brackets which are much cooler. Are you a friend of humans? Crossing your legs into a storytelling position. Picking your job based on what's funniest. How smart do you have to be to be a fridge. Pulling out your phone and opening your banking app to see how much cash is in your smart wallet. Hacking smart butt plugs. Whether hacking an insecure smart butt plug is funnier or less funny than making the smart butt plug in the first place. Login functions that don't require a password. Can you get a virus from a smart butt plug? The consequences of your smart butt plug getting taken over by hackers. Messaging all your Facebook friends explaining that your smart butt plug was hacked and if the butt plug sends a message saying "help I'm trapped in a butt plug," it's not really from you. Working for the U.S. govt hacking pacemakers. The chat is coming from inside the butt. The three names of a cat. Munkustrap, Quaxo, Coricopat, Bombalurina, and Jellylorum. A cat in profound meditation. Looking up TS Eliot in the phone book. Child Jordan Mechner looking up the lyricist of the Wizard of Oz in the phone book and calling him up. Doing a Doctor Who joke that nobody gets. How many members of The Who are still alive. Effanineffability. Up to the Neck in Weber.

An underground forum post breaks down how hackers scan, exploit, and cash out on vulnerabilities — and it reads like a step-by-step guide. Meanwhile, Microsoft is catching heat for stonewalling a researcher who found real zero-days, and a new phishing campaign is hitting small businesses through the platforms they trust most. The OG crew — Joshua Schmidt, Eric Brown, and Nick Mellem — digs into this week's biggest cybersecurity headlines with sharp takes and real-world context that practitioners can actually use. 

Jiska lehrt am HPI in Potsdam und erzählt im Podcast, wie sie dorthin gekommen ist - und was mobile Sicherheit bedeutet.

Try TrueDark glasses: https://truedark.comTry Danger Coffee: https://dangercoffee.com/Try Suppgrade Labs: https://shopsuppgradelabs.com/Over the last 15 years, I've built companies and spent millions testing what actually upgrades human performance, and I can tell you that mental fatigue has absolutely nothing to do with willpower. In this video, I break down the exact neurochemistry of deep focus. When your brain runs out of dopamine, norepinephrine, and acetylcholine, or gets bogged down by oxidative stress, your executive function collapses. The pharmaceutical industry wants you hooked on expensive stimulants that only treat the symptoms, but the real biological fix is a common antioxidant: Vitamin C.I explain how your brain hoards Vitamin C at levels 100 times higher than your blood, how to bypass the blood-brain barrier using SVCT2 transporters, and why eating sugar before you take it completely blocks its absorption. You'll also learn the exact biohacking stack—including NAC, CoQ10, PQQ, and L-theanine—you need to recycle this molecule, protect your mitochondria, and maintain effortless, razor-sharp focus all day long.Thank you to our sponsors!-KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off-Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body.-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Trailer00:21 – Focus Is Biology01:53 – Brain Chemistry Explained05:33 – Vitamin C Revealed07:09 – How to Dose08:18 – Absorption Barriers09:31 – Optimize Uptake10:00 – Oxidative Stress Problem11:00 – Stack for Deeper FocusConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

THIS IS A RERUN OF A POPULAR EPISODE - ALSO BECAUSE MARILYN IS BEING FEATURED AT THE ACADEMY MUSEUM.... #kobebryant #KOBE, #JESUSCHRIST, #JESUS, #marilynmonroe We weren't able to do a podcast tonight, "unforeseen circumstances" (isn't that funny for a podcast where we talk to the afterlife?) - but am rerunning one of our most popular podcasts, with the additional opening and subtitles, so people can "sing along with us." Just kidding. Here's the original liner notes: This was from a year ago.... For those not familiar with this podcast; Jennifer Shaffer is an intuitive medium who works with law enforcement nationwide on missing person cases. She does pro bono work daily for them, and once a week we get together and see what we can learn from the flipside.  We've been doing this weekly for 8 years, the last two on our podcast. I'm a filmmaker, have written and/or directed 8 theatrical feature films, a couple of documentaries.   Some years ago, my best friend died in my arms and started coming to visit me. Instead of being freaked out by it (and her showing up to friends and family members) I started to dig into how that might be. That's resulted in 10 books (Flipside, etc) and four with Jennifer Shaffer.  In this edition, a number of people show up that we've spoken with before. We interviewed Kobe just after his passing, it's the last chapter in the book "Backstage Pass to the Flipside 3" - where he talks about his journey, and I ask him questions in Italian. Eventually members of his family have met with Jennifer - so it's not unusual for us that he might stop by.   The construct is this; my friend who passed away is on the flipside, and has organized a "group meeting" or a class as we call it, not to teach folks on the planet, but to teach people on the flipside how to communicate using frequency, images, visualizations on the flipside. Jennifer may get an image, let's say of a character from a TV show, and it may be their way of giving her a thought so that I could say, "Do you mean someone who shares the same name of that character in the TV show wants to speak to us?" That happens often.  As noted, Jennifer is doing her best to translate what is coming to her. Like a translator at the UN, the people on the flipside are downloading a lot of information, and she does her best to catch the meaning, syntax and general idea of what someone wants to impart. A number of people stop by who've been interviewed before; Prince ("I was addicted to jumping off pianos, which caused me to use pain killers"), Robin Williams ("Love Love"). Marilyn stops by - refers to something I was writing at MartiniZone.com the other day - and when I asked if she wanted to talk about the manner of her passing, she said she wanted to talk about how she had two children waiting for her on the flipside. Both whom had not come to term.    That concept has been repeated in the research - consistently. A number of people in our podcast have mentioned it, the idea of "those we don't have are waiting for us on the flipside."  Harry Dean Stanton said the same thing - and I was able to verify it (but don't mention it in the podcast.) It's in "Backstage Pass to the Flipside."  Harry came through after he passed and before his memorial. I asked him what he wanted me to impart to his friends (as noted.) He also said that when he passed, "He was in a room with five women" and when he got to the flipside, he was met by a "baby that he didn't have in life."   In other words, a child was there to greet him with this profound unconditional love. At his memorial that I went to a week later, I asked someone who was with him at his deathbed to describe the scene. She said "There were five of us with him, all women."  I asked if he had said anything unusual while she was in the room. She said "Yes, he asked me to hand him the baby. But there was no baby in the room." I had heard THE SAME THING from Harry on the Flipside via Jennifer a week earlier. At some point, the Alpha and Omega stops by - and mentions the one thing he wishes people would not do, that is "get freaked out by his name." (Jesus). I've had a number of interviews with him via various mediums, different hypnotherapy sessions, and multiple guided meditation sessions.  As noted in the podcast, I've finished that book and am doing the audible as we speak. (SINCE THEN IT'S BEEN PUBLISHED, AS HAS THE LATEST BOOK "SHE WAS NEVER LOST" about Amelia Earhart)   As to books by scientists about how consciousness isn't confined to the brain, I recommend Dr. Greyson's AFTER, Dr. Tucker's BEFORE, Dr. Kelly's CONSCIOUSNESS UNBOUND.  In terms of the hypnotherapy research, I recommend the thousands of case studies from Dr. Helen Wambach (RELIVING PAST LIVES) Dr. Weiss (MANY LIVES, MANY MASTERS) Michael Newton (JOURNEY OF SOULS.)  My latest book is DivineCouncils.com - where I invited 50 people, half whom had never heard of councils, who visited them, met their guides, teachers, etc. Enjoy! Join this channel to get access to perks: https://www.youtube.com/channel/UCWhpYMjfbFfC0STNdWw_udw/join

Semaglutide Slows Biological Aging A randomized, placebo-controlled study published in Nature Communications found semaglutide slowed biological aging markers by nine percent on the DunedinPACE epigenetic clock in adults living with HIV-associated metabolic disease, with simultaneous improvements across inflammation, heart, kidney, liver, and brain markers. Host Dave Asprey breaks down why this isn't a weight loss story. It's a metabolic inflammation story. He explains why the GLP-1 mechanism hitting insulin signaling, oxidative stress, and inflammatory pathways simultaneously is the real finding, and makes the case that your metabolic markers and your aging markers are the same numbers. Sources: https://www.medicalnewstoday.com/articles/glp-1-drugs-ozempic-wegovy-may-slow-biological-aging https://www.nature.com/articles/s41467-026-72861-3 https://today.ucsd.edu/story/study-popular-glp-1-drug-may-slow-down-biological-aging FDA Approves First New Sunscreen Ingredient in 20 Years The FDA approved bemotrizinol as a permitted OTC sunscreen active ingredient, the first new approval in roughly two decades, clearing it for adults and children six months and older with broad UVA and UVB coverage and low skin absorption. Host Dave Asprey explains why twenty years of regulatory lag left American consumers with inferior chemistry while Europe moved on, why he's watching independent absorption data before updating his own stack, and why consistency of use matters more than perfect formulation when sun protection remains one of the most evidence-backed longevity interventions available. Sources: https://www.fda.gov/news-events/fda-newsroom/press-announcements/fda-expands-sunscreen-options-first-time-20-years https://www.accessdata.fda.gov/scripts/cder/omuf/index.cfm?event=OrderDetail&orderid=OTC000039 https://www.usatoday.com/story/news/health/2026/06/09/new-sunscreen-ingredient-bemotrizinol/90477659007/ Deoxyribose Gel Matches Minoxidil in Hair Regrowth Study Researchers testing a topical gel made from deoxyribose, the sugar backbone of DNA, saw roughly 80 to 90 percent hair regrowth in a mouse model of male-pattern baldness, matching minoxidil results and showing new follicle formation and increased blood vessel activity in treated areas. Host Dave Asprey breaks down why mouse hair regrowth studies have a long history of failing to translate to humans, what a plausible circulation-based mechanism would actually need to show in human trial data before it's worth acting on, and why the molecule itself is interesting enough to keep watching. Sources: https://www.reddit.com/r/Biohackers/comments/1tyt87w/researchers_found_that_a_gel_made_from/ https://www.sciencealert.com/surprise-hair-loss-breakthrough-a-dna-sugar-gel-sparks-robust-regrowth Caffeinated Chewing Gum and Exercise Performance A systematic review and meta-analysis of 21 studies found caffeinated chewing gum produces a small but real ergogenic effect for muscular strength and countermovement jump height, with buccal absorption delivering caffeine faster than capsules or drinks in a five to twenty-five minute pre-training window. Host Dave Asprey breaks down why delivery mechanism is an underrated variable in caffeine optimization, why timing matters as much as dose, and why a modest but measurable edge on a cheap and accessible tool is exactly the kind of practical biohack worth understanding. Sources: https://pubmed.ncbi.nlm.nih.gov/42228847/ https://doi.org/10.1519/JSC.0000000000005530 https://www.reddit.com/r/Biohackers/comments/1u0acgc/fastacting_caffeine_does_caffeinated_chewing_gum/ Vitamin A Overdoses Surge Nearly 40 Percent Medical News Today reported a 38.7 percent spike in vitamin A overdoses in early 2025, driven by online misinformation claiming high-dose vitamin A treats or prevents measles, a claim with no clinical support and real toxicity risk from fat-soluble accumulation in the liver. Host Dave Asprey explains the actual hepatotoxicity and bone demineralization risks of preformed retinol excess, draws the critical distinction between preformed retinol and beta-carotene that got lost in the misinformation cycle, and makes the case that mechanism is not a dosing protocol and confusing the two is how people get hurt. Sources: https://www.medicalnewstoday.com/amp/articles/vitamin-a-overdoses-rose-by-38-7-2025-how-to-get-right-amount World Cup 2026 and Mass Gathering Health Risk With the 2026 FIFA World Cup underway, public health researchers are flagging dense international crowds, high-volume travel, and shared indoor and outdoor spaces as an elevated transmission environment for respiratory illness. Host Dave Asprey reframes the conversation away from germ exposure and toward immune terrain, explains why your resilience going into a high-contact environment is a variable you actually control, and lays out the pre-exposure preparation window that matters most for anyone traveling or attending large events this summer. Sources: https://www.healthline.com/health-news/2026-fifa-world-cup-health-risks-protect-yourself This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on GLP-1 aging biology, sunscreen chemistry and regulatory science, emerging hair regrowth research, caffeine delivery optimization, supplement toxicity risk, and immune terrain preparation for mass gathering events. Host Dave Asprey connects randomized clinical data, epigenetic clock research, consumer health regulation, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: semaglutide biological aging, GLP-1 epigenetic clock, DunedinPACE aging marker, PCGrimAge mortality risk, bemotrizinol FDA approval, new sunscreen ingredient 2026, UVA UVB broad spectrum sunscreen, deoxyribose hair gel, minoxidil alternative hair regrowth, caffeinated chewing gum performance, buccal caffeine absorption, pre-workout caffeine timing, vitamin A overdose toxicity, preformed retinol hypervitaminosis, fat-soluble vitamin accumulation, World Cup 2026 health risk, immune terrain optimization, mass gathering respiratory illness, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:41 – Story 1: Ozempic Slows Aging Clocks 01:53 – Story 2: New Sunscreen Approved 03:12 – Story 3: DNA Sugar & Hair Regrowth 04:38 – Story 4: Caffeine Gum & Performance 06:13 – Story 5: Vitamin A Overdose Spike 07:59 – Story 6: World Cup & Immune Prep 09:34 – Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

More Bitlocker Issues: GreatXML https://git.churchofmalware.org/Nightmare_Eclipse/GreatXML Security Advisory Ivanti Sentry (CVE-2026-10520, CVE-2026-10523) https://hub.ivanti.com/s/article/Security-Advisory-Ivanti-Sentry-CVE-2026-10520-CVE-2026-10523?language=en_US Oracle Security Alert Advisory - CVE-2026-35273 https://www.oracle.com/security-alerts/alert-cve-2026-35273.html https://www.bleepingcomputer.com/news/security/oracle-mitigates-peoplesoft-zero-day-exploited-in-data-theft-attacks/ How Deceptive Installers Are Targeting macOS Users https://www.huntress.com/blog/deceptive-installers-macos-infostealers My Upcoming Classes https://www.sans.org/profiles/dr-johannes-ullrich

How to Reverse Cognitive Decline, Grow Your Hippocampus, and Protect Your Brain from Alzheimer's Disease with Nutrition, Exercise, Sleep, and Stress Reduction Your brain is physically shrinking right now, and most people have no idea it's happening. In this episode, you will discover the exact mechanisms behind cognitive decline, why brain fog is always treatable, and the proven strategies to grow your brain back, protect your memory, and slash your Alzheimer's risk regardless of your genetics. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Majid Fotuhi, a neuroscientist and neurologist who earned his PhD from Johns Hopkins University and his medical degree from Harvard Medical School. He currently serves as an adjunct professor at the Mind/Brain Institute at Johns Hopkins while also teaching at George Washington University and Harvard Medical School. With 37 years of experience in clinical practice, teaching, and neuroscience research, Dr. Fotuhi pioneered the Brain Fitness Program, a multidisciplinary approach to cognitive performance and brain vitality at any age that has produced measurable results documented in peer-reviewed journals. He is the author of three books including the bestselling The Invincible Brain and one of the world's leading experts on neuroplasticity, hippocampus growth, and successful aging. If anyone has earned the right to tell you your brain can get better, it is him. Dr. Fotuhi and Dave break down why Alzheimer's is not a single disease but a soup of modifiable problems, why your lab results can show "normal" while your brain is starving, and how the five pillars of brain health connect directly to longevity, mitochondria function, and human performance. They also get into the brain effects of GLP-1s, the therapeutic promise of psychedelics like psilocybin and ketamine, the role of nootropics and supplements like B12, lithium orotate, and CoQ10, and why your VO2 max may be the single most important number for brain aging. . You'll Learn: Why 97% of Alzheimer's cases involve multiple modifiable causes and what to do about each one How to physically grow your hippocampus through exercise, meditation, and nutrition Why "normal" lab ranges are actively harming millions of people and what optimal actually looks like The 7 everyday things that are shrinking your brain right now How stress, loneliness, and isolation cause measurable brain atrophy Which supplements including B12, lithium orotate, CoQ10, and nootropics support long-term brain health Why VO2 max predicts brain aging better than almost any other marker What psychedelics like psilocybin and ketamine actually do to your brain according to a Johns Hopkins neurologist How the APOE4 gene affects Alzheimer's risk and why exercise can erase that risk entirely Why mitochondria health is the foundation of both brain function and longevity Thank you to our sponsors! - Viome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body. - BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. - Pique | Go to Piquelife.com/dave for 20% off. - BodyHealth | Visit BodyHeath.com and use code DAVE20 for 20% off your first purchase Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Majid Fotuhi, Dr. Majid Fotuhi, The Invincible Brain, brain health, cognitive decline, Alzheimer's prevention, hippocampus, neuroplasticity, brain fog, memory loss, APOE4, brain shrinkage, B12 deficiency, lithium orotate, CoQ10, nootropics, VO2 max, mitochondria, longevity, anti-aging, biohacking, brain optimization, sleep optimization, stress reduction, functional medicine, human performance, psilocybin, ketamine, GLP-1, semaglutide, telomeres, BDNF, brain training, cognitive performance Resources: • Learn More About Dr. Fotuhi's Work At: https://drfotuhi.com/ • Purchase Dr. Fotuhi's New Book The Invincible Brain: https://a.co/d/0iHCgPpL • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 00:59 – Intro 03:00 – Cannabis & Nicotine 04:15 – Understanding Alzheimer's 05:38 – Five Pillars Explained 07:55 – Best Cognitive Training 09:08 – Brain Size & Growth 12:36 – B12 & Lab Ranges 17:48 – Head-to-Toe Evaluation 24:17 – Sex & Brain Health 25:43 – Loneliness & Isolation 33:59 – ApoE4 Genetics 35:28 – Alzheimer's Declining 48:44 – Lithium & Brain 59:38 – VO2 Max & Fitness 1:06:42 – Psychedelics 1:09:38 – GLP-1s & Brain 1:12:38 – Closing & Action Steps See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How has use of framing protection security headers changed in the past 3 years? https://isc.sans.edu/diary/How%20has%20use%20of%20framing%20protection%20security%20headers%20changed%20in%20the%20past%203%20years%3F/33068 Preparing for npm v12: install scripts and non-registry sources become opt-in https://github.com/orgs/community/discussions/198547 Adobe Patches https://helpx.adobe.com/security.html Rogue Planet new Microsoft Defender Vulnerability https://github.com/MSNightmare/RoguePlanet My Upcoming Classes https://www.sans.org/profiles/dr-johannes-ullrich

On this week's Totally Extra: Anna's full taken up the hunting Tesco name badges for long-service staff hobby, Lu's confessing to some poetry theft, whatever 'Nippy Nippy' is, a misheard lyric that's basically incest, the teacher gift debate, and confessions involving hacking a classmate's computer and a 43-year-old bogey eater. Enjoy your lunch.It's time to get TOTALLY EXTRA. Extra chat, extra rants, extra bants, extra stories, nonsense and more.LuAnna: The Podcast is a Global production, available every Monday and Thursday on Global Player, YouTube or wherever you get your shows. Make sure you subscribe so you never miss an episode.Remember, if you want to get in touch you can:Email us at luanna@everythingluanna.com OR drop us a WhatsApp on our NEW NUMBER: 07521564640Please review Global's Privacy Policy: https://global.com/legal/privacy-policy/

Are we prepared for the deployment of a functional quantum computer? This week, Technology Now is returning to the topic of post quantum cryptography. We ask why the deadline for migrating to PQC enabled systems has been moved up, we discover what a quantum computer actually needs to be cryptographically relevant, and we pose the question: when it comes to migrating your systems to quantum resistant forms of encryption, could it already be too late for some people to start?This is Technology Now, a weekly show from Hewlett Packard Enterprise. Every week, hosts Michael Bird and Sam Jarrell look at a story that's been making headlines, take a look at the technology behind it, and explain why it matters to organizations.

We just wrapped up our Hacking for Defense class at Stanford. This was the 11th year we've taught Hacking for Defense, and the impact of asymmetric warfare, (drones, off-the-shelf technologies, etc.,) disruptive technologies (AI, commercial access to space) and a startup friendly DoW acquisition system – make it feel like a much different class than the previous classes.

This week, BJ is joined by Dr. Robert Lustig. A Professor emeritus of Pediatrics, Division of Endocrinology at UCSF, and the author of numerous books you should read, including The Hacking of the American Mind, which is the subject of this week's interview. Dr. Lustig had a lot to say about the power corporations wield over us, Citizens United, and why you should cut as much sugar from your diet as you can. That's because, like the end result of Citizens United, sugar could kill you. Politically speaking of course.

Microsoft June 2026 Patch Tuesday https://isc.sans.edu/diary/Microsoft%20June%202026%20Patch%20Tuesday/33064 Miasma Software Supply Chain Attack Toolkit Source Published https://safedep.io/inside-the-miasma-supply-chain-attack-toolkit/ Fortinet FortiSandbox Vulnerability https://fortiguard.fortinet.com/psirt/FG-IR-26-141 My Upcoming Classes https://www.sans.org/profiles/dr-johannes-ullrich

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Chad Jones, a professor of economics at Stanford Graduate School of Business, recently published a paper, “AI and Our Economic Future.” Using more than 100 years of economic data, he modelled several potential AI-infused economic futures we may experience. These include the good (abundance, we never work again), the not-so-bad (business more or less as usual), and the ugly (a superintelligence that turns on us, among other catastrophic options). Cheery stuff, Jones acknowledges, but essential to face.“I think the ability for an AI to do everything on a computer that the best software engineer can do, that seems like it's either here now or will be here within five years easily,” Jones says. “Hacking the electric grid, hacking the financial system, these kinds of scenarios are things that we definitely have to worry about. The good news is, I think if we get through that, the ability of AI to transform the economy for good, it is really there and present. And, that would be a very great and bright future.”Related Content:Chad Jones faculty profileWhat's the Price Tag for Preventing an AI Apocalypse?At What Point Do We Decide AI's Risks Outweigh Its Promise? Chapters:00:00:00 Introduction00:01:32 The difference between now & previous periods of innovation00:02:29 Two scenarios for AI-driven growth00:06:18 The case for business-as-usual00:11:06 Weak links and the limits of automation00:17:53 What the models are showing about growth00:19:58 The economics of abundance00:25:29 The weak-link model's timing & possible adaptations00:27:51 Who gains in an AI economy?00:29:55 Catastrophic risk and the downside of acceleration00:34:31 The downsides of the weak link model00:36:38 Meaning, identity, and human value00:39:55 Leisure in a post-work world00:41:43 What the next generation may inherit00:44:07 ConclusionIf/Then, from Stanford GSB, features conversations with faculty that explore how their research deepens our understanding of business and leadership.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

He posted 400 times on Instagram with 50 followers. Most people would have quit. James Dumoulin just kept going.  I've been waiting to have this young man on for a while, and he did not disappoint. At 23 years old, James has built something I genuinely did not think was possible at this age: 21 million followers, 200 million views a month, 70 employees, and 48 billionaire interviews including Tom Cruise, Tom Brady, Will Smith, and Reid Hoffman. He built all of it from scratch, starting as a Chick-fil-A employee who saw TikTok as a marketing engine before anyone else did. James is the co-founder of the School of Hard Knocks, and what he has learned sitting across from the wealthiest people in the world will hit you in the best way possible. In this conversation, we go deep on what it actually takes to build something great when you have no connections, no credibility, and no one betting on you. James breaks down the exact strategy he used to get into rooms most people will never see, including how he cold-approached Mark Cuban at South by Southwest with nothing but nerve and a borrowed title. We talk about what the wealthiest people in the world actually have in common, whether money buys happiness, and why your age, your background, or your starting point is not the obstacle you think it is. James also gets honest about the moments where it almost fell apart, including the day their revenue dropped from $30,000 a month to under $5,000 overnight and what he did to rebuild. This is one of the most practical, fire conversations I've had in a long time, and James is the real deal. Here's what you'll gain from this episode: The Authority Hack: How James borrowed credibility he didn't have yet to get in rooms most people will never see, and how you can do it starting today with what you already have. Billionaires Think in Decades: The single mindset shift James observed in every billionaire he's interviewed, and why your obsession with the short term is the real thing holding you back. Concentration Builds Wealth: Why trying to do too many things too early is the silent killer of most businesses, and what the wealthiest people actually do first. The Rejection Blueprint: Why James says "no" just means "not yet," and how posting 400 times with 50 followers is what actually built a business doing $700,000 a month. Are Billionaires Actually Happy? What James has witnessed behind the scenes with some of the most successful people in the world, and the one thing the happiest ones all have in common.  This is one of those conversations that changes the way you think about what's actually possible. Don't miss this one! Try QUO for free PLUS get 20% off your first 6 months when you go to ⁠https://quo.com/mylett Get your choice of a healthy free protein staple like chicken breast for a year or ground beef in every box for LIFE PLUS $20 off when you go to https://ButcherBox.com/mylett

Dr. William Li: Eat to Beat Disease, Extend Longevity, and Hack Your Vascular Health Your body already has a built-in cancer defense system, and the foods you eat can rival prescription drugs at activating it. In this episode, you'll discover what 720,000 living centenarians reveal about longevity, why microplastics are reaching your brain through your nose, and how your blood vessels hold the real key to biological aging. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. William Li, an internationally renowned physician, scientist, and two-time New York Times bestselling author of "Eat to Beat Disease" and "Eat to Beat Your Diet." As President and Medical Director of the Angiogenesis Foundation, Dr. Li's groundbreaking research has led to the development of more than 40 new medical treatments impacting care for over 70 diseases including diabetes, heart disease, blindness, and obesity. His TED Talk, "Can We Eat to Starve Cancer?", has surpassed 11 million views, making him one of the most trusted voices at the intersection of functional medicine and food as medicine science. Together they dig into the biology of SuperAgers, the vascular markers that predict how long you'll live, and why flow-mediated dilation may be the most underrated biohacking measurement tool available today. Dave shares what happened after four separate gene therapies, including klotho and VEGF, and Dr. Li explains why your metabolism, mitochondria, and gut microbiome show up in the data on every centenarian ever studied. They also get into the microplastic crisis, the cribriform plate pathway that delivers airborne particles directly to your brain, and why your tongue is the first place your body quietly stores fat. You'll Learn: What centenarian research reveals about immune function, gut health, and vascular resilience Why 50% of food extracts matched or outperformed cancer drugs in head-to-head angiogenesis testing How microplastics travel through your nose directly to your central nervous system What flow-mediated dilation and pulse wave velocity tell you about your true biological age Why your hind-third tongue fat is an overlooked early warning sign for sleep apnea and metabolism problems What Dave's four gene therapies (klotho, VEGF, follistatin) actually did to his body How the vagus nerve connects gut health to brain optimization, stress resilience, and longevity Why genetics now accounts for roughly half of longevity outcomes, and what that means for the future of gene therapy How to use biohacking tools to compound your health the same way you compound financial returns Thank you to our sponsors! - Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com. - Amp | If you're ready to make fitness fit into your life, go to amp.ai to check it out - Caldera + Lab | A small habit with big results. Go to CalderaLab.com/DAVE and use code DAVE for 20% off your first order. - Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: William Li, Dr. William Li, Eat to Beat Disease, angiogenesis, food as medicine, centenarians, SuperAgers, longevity, anti-aging, biohacking, vascular health, flow-mediated dilation, pulse wave velocity, microplastics, cribriform plate, gene therapy, klotho, VEGF, follistatin, mitochondria, metabolism, gut health, vagus nerve, sleep apnea, functional medicine, human performance, brain optimization, cancer prevention, inflammation, immune system Resources: • Learn More About Dr. Li's Work At: https://drwilliamli.com • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 02:33 – William's Background 06:21 – Food vs. Cancer Drugs 14:09 – Gene Therapy 23:50 – Centenarian Research 27:41 – Stress & the Vagus Nerve 37:31 – Vascular Health 42:34 – Microplastics 53:19 – Novel Biomarkers See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Azure Functions Action and 72 Other Repositories Disabled After Supply Chain Attack https://www.stepsecurity.io/blog/miasma-worm-hits-microsoft-again-azure-functions-action-and-72-other-repositories-disabled-after-supply-chain-attack-targeting-ai-coding-agents Active Exploitation of Check Point VPN Authentication Bypass (CVE-2026-50751) https://blog.checkpoint.com/security/check-point-releases-important-hotfix-for-vulnerabilities-in-deprecated-ikev1-vpn-protocol/ Missing IPsec Integrity Protection for IMS SIP Signaling in Verizon VoLTE Deployments https://kb.cert.org/vuls/id/615987 My Upcoming Classes https://www.sans.org/profiles/dr-johannes-ullrich

Anyone can build software with AI now, and millions of people are giving it a try. But when AI can spin up an app in minutes, are security risks slipping through the cracks?

America's national security challenges are evolving faster than ever—and the traditional defense innovation system is struggling to keep pace. In this episode of State Secrets, Cipher Brief CEO Suzanne Kelly sits down with two of the most influential voices in defense innovation: Steve Blank, creator of the Lean Startup methodology and co-founder of Hacking for Defense, and Pete Newell, retired Army officer, founder of BMNT, and co-founder of Hacking for Defense. Together, they discuss how students at leading universities are tackling real-world challenges from the Pentagon, intelligence community, and NASA; why AI is changing the way innovators build solutions; and what it will take for the United States to compete with increasingly adaptive adversaries like China. The conversation explores defense acquisition reform, the Pentagon's innovation ecosystem, startup culture in national security, the rise of defense venture capital, and why the biggest challenge may not be technology—but people.

High-level policy decrees and exciting national security headlines don't win wars. Execution does.This week, Meagan Metzger (Founder & CEO of Dcode) joins Tyler Sweatt to pull back the curtain on the unsexy, high-stakes reality of defense acquisition reform. While leadership pushes for rapid commercial tech adoption, the "fingers-on-keyboards" workforce is left managing legacy constraints, budget shifts, and an inherent fear of administrative risk.What's happening on the second front:The critical execution gap between strategic mandates and tactical reality.Re-engineering the internal operating models of DoW programs to maximize authorities.Why commercial founders must understand the defense ecosystem better than their buyers.Transitioning from line-item product procurement to budgeting for mission outcomes.Realigning the incentives within federal labs and research communities toward true mission impact.Connect with MeaganLinkedIn: Meagan MetzgerConnect with TylerLinkedIn: Tyler Sweatt

The Evil MSI Background is Back! https://isc.sans.edu/diary/The%20Evil%20MSI%20Background%20is%20Back!/33054 The Smart TV in Your LivingRoom Is a Node in the AIScraping Economy https://blog.includesecurity.com/2026/06/the-smart-tv-in-your-livingroom-is-a-node-in-the-aiscraping-economy/ Brute force attack on Dashlane user accounts https://support.dashlane.com/hc/en-us/articles/36038764990866-Security-advisory-Brute-force-attack-on-Dashlane-user-accounts#update-jun-4 My Upcoming Classes https://www.sans.org/profiles/dr-johannes-ullrich

Josh welcomes back François Proulx to talk about the absolute madness in the CI/CD universe right now. We also learn about François' new project SmokedMeat which is a tool to help you hack your own CI/CD. When Josh spoke to François a year ago, the world was a very different place than it is today. François has a ton of knowledge about how we got here and what we can do moving forward. Boost Security has a bunch of amazing open source tools François built that can help keep CI/CD systems understood and locked down. The show notes and blog post for this episode can be found at https://opensourcesecurity.io/2026/2026-06-françois-smoked-meat/

I used to weigh 300 pounds. I tried every restrictive diet, became a vegan, and trained 90 minutes a day for 18 months with absolute zero results. Everything changed when I drank a cup of yak butter tea at 18,300 feet in Tibet. Within 30 seconds, my severe brain fog lifted, and my metabolism completely shifted.In this video, I break down exactly why adding sugar to your morning coffee is destroying your metabolism, spiking your insulin, and keeping you fat. I explain the hard science behind the alternative: blending "fat cubes" (grass-fed butter) and MCT oil into your coffee. I reveal how this specific combination of butyrate, CLA, and medium-chain triglycerides bypasses traditional digestion to go straight to your liver, instantly converting into ketones for pure brain fuel. You'll learn how eating more fat actually trains your body to burn its own stored fat, allowing me to hit 4.8% body fat at 50 years old with a biological age in my 30s—without hunger, without a 3 PM crash, and without living in the gym.Thank you to our sponsors!Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayViome | Check it out at viome.com and use code 10DAVE for 10% off. It's time to stop guessing and start knowing your body.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:0:00 – Intro 00:42 – Pancreatic Cancer Halted by Virus Injection 01:44 – Teens & AI Therapy Chatbots 03:13 – GLP-1 Drugs Cut Breast Cancer Risk 04:30 – Russia's $26B Longevity Program 06:18 – Sauna vs. Cold Plunge 09:10 – ClosingConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today we unpack the massive global hack of the Canvas Learning Management System in May 2026 that impacted some 9000 education institutions and stole an estimated 275 million users' data. To discuss this event and its implications with me is Claire Bond Potter. Claire Bond Potter is Professor of History emeritus at The New School for Social Research, author of the Political Junkie Substack, and creator of Why Now?, a political-history podcast . Her latest article in Chronicle of Higher Education is entitled Kill Canvas. Now. freshedpodcast.com/potter -- Get in touch! LinkedIn: @FreshEdpodcast Facebook: FreshEd Email: info@freshedpodcast.com

Another fun episode. In this episode, we talk about the amazing adventure going to the set of Beyond Belief with Jimmy Church talking about Amelia Earhart.  Amelia shows up to give her two cents about the show , then Prince shows up to remind us that June 7th is "Prince Day" - and reiterates we should dance, sing, play some of his tunes... why not?  I ask a question to Stephen Hawking about his journey - he makes a joke about speeding away from the Epstein files... and I ask him about that as well.  Mind bending stuff. (not going down that path, but did ask him if he feels embarrassment or any reaction) - then "Five" steps in to rescue him and talk about the akashic library. All in all another mind bending session. enjoy!

NEW: Send us Your Comments!This Week's Topics:House Votes to Stop Iran War 3:00Iran threatens to block Access to Red Sea 5:00FBI Arrests Iranian Spy in California 7:00DOJ Charges 9 In Ohio with Fraud 10:00VIDEO: Feds Create System to Catch Fraud 12:30VIDEO: Dr. Oz Blows Up Obamacare Fraud 20:00Mullin Shows Antifa Behind NJ Riots 24:30Senate FINALLY Move to Fund ICE 27:30The Truth about Data Centers 30:00Data Center Build-Out's Falling Behind 39:30Trump Signs AI “Cyber Defense” EO 42:30We Got One! John Bolton Takes Plea Deal! 44:30Proof Hunter Biden Laptop was Deep State 45:30Trump Calls Out California Election Fraud 47:00VIDEO: Trump Defends Jan 6th Patriots 48:30SCOTUS Allows New Alabama Voting Map 50:00Trump Act to END Illegal Voting by Mail 50:30Butler Shooting Victims Sue Feds 54:00Trump Reclassifies 8,000 Senior Feds 1:03:30Trump Acts to Help Coal Industry 1:07:00New Bill Hopes to increase supply of Home 1:10:00US Adds 172,000 New Jobs in May! 1:12:00More Charges against SPLC filed 1:15:00Big Problems for NASA Moon Plans 1:17:30FBI Warns about Hacking of Gas Stations 1:20:3060 Minutes is Getting Un-Woke Fast 1:22:00Covid Vaccines May be causing Cancer 1:26:30VIDEO: Proof Ivermectin Works! 1:28:30NY Dems to remove “Mother” & “Father” 1:32:00Support for Gay Marriage & LGBTQ Falling 1:34:00Republicans FAIL to Stop Transgender Laws 1:37:00Samsung Leaves NJ for Texas 1:38:30Beck RIPS Krugman's De-MAGAfication 1:39:00Dem's Hated by their own Voters 1:48:30Support the showView our Podcast and our other videos and news stories at:https://wethepeopleconvention.org/Podcast-Player-PageSend Comments and Suggestions to:info@WethePeopleConvention.org

Pancreatic Cancer Halted by Virus Injection Researchers injected an engineered virus directly into pancreatic tumors in three patients — the virus replicated inside malignant cells, triggered an immune response, and stopped tumor growth and spread at an intentionally low early dose. Host Dave Asprey breaks down why oncolytic viruses can do what chemotherapy can't, how the tumor's dense biological wall becomes less of an advantage when a virus can replicate inside it directly, and why a measurable response at a safety dose is the kind of early signal that changes how he's watching this field. Sources: https://www.newscientist.com AI Chatbots and Teen Mental Health A new survey shows roughly one in five adolescents and young adults are now going to AI chatbots when they feel sad, anxious, nervous, or stressed, with usage heaviest in the 18–21 range. Host Dave Asprey explains why general-purpose language models designed to be engaging are dangerous as a substitute for real mental health support, why false reassurance from a chatbot may make the pipeline to real care harder to reach, and why this is a health systems story masquerading as a tech adoption story — and what parents need to do about it. Sources: https://www.nbcnews.com GLP-1 Drugs Cut Breast Cancer Risk Penn Medicine published a retrospective analysis of over 111,000 women finding GLP-1 exposure associated with about 35% lower odds of breast cancer in the full cohort and around 30% lower in a matched comparison group. Host Dave Asprey breaks down why this isn't just a weight loss story — it's a metabolic dysfunction story — explains the insulin resistance, inflammation, and hormonal environment mechanisms that may be driving the signal, and makes the case that this finding should be reshaping how oncologists and OBGYNs think about high-risk patients right now. Sources: https://www.pennmedicine.org Putin's $26 Billion Longevity Program The Wall Street Journal reports that Russia has made anti-aging research a Kremlin-level national priority through a $26 billion program including gene therapy, organ bioprinting, and xenotransplantation, led by Putin's daughter Maria Vorontsova and physicist Mikhail Kovalchuk. Host Dave Asprey breaks down what's geopolitical theater, what's legitimately frontier science, and why the real question is whether any findings will make it out to the broader research community or get locked inside a state program. Sources: https://www.wsj.com https://www.france24.com Sauna vs. Cold Plunge A landmark Finnish study tracked over 2,300 men for nearly 21 years and found increasing sauna frequency associated with dramatically lower cardiovascular and all-cause mortality — strongest at four or more sessions per week. Host Dave Asprey settles the debate with the actual data, explains what heat shock proteins and cold shock proteins actually are and why the evidence base behind them is nowhere near equivalent, and calls out the wellness marketing presenting early-stage mouse model research as the cold water equivalent of two decades of human mortality outcomes. Sources: https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2521522 This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on cancer treatment breakthroughs, adolescent mental health and AI, metabolic drivers of disease, geopolitical longevity science, and the real evidence behind popular recovery modalities. Host Dave Asprey connects emerging clinical research, objective epidemiological data, and real-world optimization protocols into actionable frameworks for extending healthspan, sharpening performance, and staying ahead of the science. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: oncolytic virus pancreatic cancer, engineered virus tumor treatment, AI chatbot teen mental health, adolescent AI emotional support, GLP-1 breast cancer risk, semaglutide cancer prevention, metabolic dysfunction root cause disease, Putin longevity program Russia, New Health Preservation Technologies, anti-aging biotech geopolitics, sauna longevity mortality data, cold plunge cold shock proteins, RBM3 heat shock proteins, sauna vs cold plunge evidence, biohacking news 2026, longevity research, Dave Asprey, The Human Upgrade Thank you to our sponsors! - Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today - Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:42 – Pancreatic Cancer Halted by Virus Injection 01:44 – Teens & AI Therapy Chatbots 03:13 – GLP-1 Drugs Cut Breast Cancer Risk 04:30 – Russia's $26B Longevity Program 06:18 – Sauna vs. Cold Plunge 09:10 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Microsoft's Coreutils for Windows https://isc.sans.edu/diary/Microsoft%27s%20Coreutils%20for%20Windows/33048 Cisco Unified Communications Manager Server-Side Request Forgery Vulnerability CVE-2026-20230 https://sec.cloudapps.cisco.com/security/center/content/CiscoSecurityAdvisory/cisco-sa-cucm-ssrf-cXPnHcW Firmware Update for Acer Connect W6x Router https://community.acer.com/en/kb/articles/19672 OAuth marketplace apps keep access after publishers vanish https://www.helpnetsecurity.com/2026/06/04/oauth-marketplace-apps-audit/ My Upcoming Classes https://www.sans.org/profiles/dr-johannes-ullrich

Today our hosts talk about their favorite off-label uses for pedals: an Expression Ramper as an expression splitter, a trereo overdrive pedal as a lofi tape machine, a pedal with perfectly spaced knobs as a phone holder, etc. They take calls and some comments from the Discord, all focused around pedal usage that goes beyond the marketing and expectations of the user interface into unexpected sonic corners. Buy some Old Blood: https://oldbloodnoise.com/ Join the conversation in Discord: https://discord.com/invite/PhpA5MbN5u Follow us all on the socials: @carolinegco, @danfromdsf, @andyothling, @oldbloodnoise Subscribe to OBNE on Twitch: https://www.twitch.tv/oldbloodnoise Leave us a voicemail at 505-633-4647!

Sulforaphane, Detox Pathways, and the Science of Microplastic Removal Microplastics are building up inside your brain, blood, and reproductive tissue, and most detox protocols do nothing to remove them. This episode gives you the cellular science behind why toxins accumulate, which three detox pathways control your ability to excrete them, and what the latest research shows actually moves microplastics, heavy metals, BPA, and benzene out of your body.. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. Host Dave Asprey sits down with Dr. John Gildea, a Johns Hopkins-trained PhD with 60 scientific publications and over 20 NIH-funded studies, and David Roberts, co-founder of Mara Labs and co-creator of BrocElite, the only naturally derived stable form of sulforaphane available in a capsule. Together they bring decades of research-backed biohacking and functional medicine insight into one of the most pressing longevity conversations of our time. They break down the lysosome, your cell's built-in incinerator, and explain exactly why it gets clogged with microplastics, advanced glycation end products, and other toxins that won't break down. New research shows that sulforaphane triggers a process called lysosomal surface translocation, which releases those trapped particles so your body can finally excrete them. An in-house Mara Labs study confirmed the excretion pathway: microplastics come out in feces. In the original study, the individual measured the highest microplastic levels ever recorded, and a repeat study a year later showed dramatically lower baseline microplastic levels, suggesting consistent use compounds the benefit over time. You'll Learn: Why microplastics accumulate inside lysosomes and what sulforaphane does to release them How the three detox pathways, glutathione, glucuronidation, and sulfation, work together to remove every major class of toxin What an in-house study revealed about how and where microplastics actually leave the body How toxic estrogen metabolites form and why sulforaphane is the most effective natural tool to reroute them Why berberine supports sleep optimization, ketosis, and blocks a cancer growth pathway most drugs cannot touch How sulforaphane boosts BDNF and neuroplasticity at the cellular level What microplastic sources in your home, including your dryer, rugs, and receipts, are doing to your toxin load daily Why losing weight releases stored toxins and what to take to protect your brain and metabolism during fat loss How sulforaphane activates the same AMPK longevity pathways triggered by fasting without restricting food Thank you to our sponsors! - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - Timeline | Go to timeline.com/dave and you'll get an additional 20% off your first month - Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. John Gildea, David Roberts, Mara Labs, BrocElite, sulforaphane, microplastics, microplastic removal, lysosome, lysosomal surface translocation, detox pathways, glutathione, glucuronidation, sulfation, Nrf2 pathway, AMPK, TFEB1, BDNF, neuroplasticity, heavy metals, BPA, benzene, estrogen metabolism, toxic estrogen, xenoestrogens, berberine, BerbaLite, ResveraLite, c-Myc, cancer and estrogen, sleep optimization, ketosis, broccoli sprouts, isothiocyanates, PEITC, watercress, phase two detox, microplastic excretion, indoor air quality, HEPA filter, dryer lint microplastics, BPA receipts, endocrine disruptors, fat loss and toxins, autism and sulforaphane, ADHD and focus, vivid dreams and BDNF, fasting mimicry, anti-aging, biohacking, longevity, functional medicine, supplements, human performance, brain optimization, metabolism, cellular detox Resources: • For next week, 25% off all Mara Labs products when you go to www.mara-labs.com/DAVE and use code DAVE at checkout. After June 11th, the code will return to the standard 15% off. • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 – Trailer 1:55 – Intro & Context 4:48 – Microplastics & Sulforaphane 12:39 – Broccoli Sprouts Formulation 15:20 – Lab Origin Story 26:01 – Reducing Toxin Exposure 37:06 – Estrogen, Hormones & Berberine 52:46 – Autism, ADHD & Brain Health 59:01 – Wrap-Up See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Continuing Scans for swagger.json https://isc.sans.edu/diary/Continuing+Scans+for+swaggerjson/33044/#comments Fake call detection on Android https://blog.google/security/android-fake-call-detection/ Anthropic's coordinated vulnerability disclosure dashboard https://red.anthropic.com/2026/cvd/ My Upcoming Classes https://www.sans.org/profiles/dr-johannes-ullrich

This week, the team discusses why the race among the top AI companies to go public has just gotten started but it is already creating bizarre repercussions — including numerous San Francisco real estate listings preferring Anthropic's stock instead of cash. They also get into why Trump's new executive order on AI safety is underwhelming, and how hackers were able to use Instagram's AI chatbot to access high profile accounts, like President Obama's. Plus, Leah reports on how a DOGE whistleblower is suing Elon Musk for defamation after the billionaire publicly called him a liar, and the next thing he knew — his life was in danger.  Articles mentioned in this episode: What's Worth More Than Cash in San Francisco Real Estate? Anthropic Stock | WIRED This Is How Trump Finally Signed the AI Executive Order | WIRED He Blew the Whistle on DOGE. Then His Brakes Were Cut | WIRED  Join WIRED's best and brightest on Uncanny Valley as they dissect the collision of tech, politics, finance, and business, from the newest ventures to the effects of inaccurate information from artificial intelligence (AI) chatbots on social protests. Learn about your ad choices: dovetail.prx.org/ad-choices

"It is no secret that music contracts can be rather brutal on artists. Often the stories focus on not getting paid but there is also the interesting idea of a lawsuit ordering a musician to fill his or her contract and record what we are calling a court ordered album. We have multiple examples plus one where the band was paid NOT to record an album."

"The New York Times released their 30 Greatest Living American Songwriters list a short while ago. I know online lists usually have some click bait to start conversation but this list was overtly egregious. Not for who was on it. It was who was left off. We will go over the list and play some artists that should have been on there."

"Sony Music Publishing confirmed an agreement to acquire Blackstone's Recognition Music Group catalog for $3.5 billion. The Red Hot Chili Peppers just sold their catalog for $300 million. Other Funds are raising billions to start buying. These buyers are called Music Rights Funds. I became interested in how these Funds actually made money. How does one invest and can I sell my own music. I have the answers for you."

New Wave Of Phishing Emails with SVG Files https://isc.sans.edu/diary/New%20Wave%20Of%20Phishing%20Emails%20with%20SVG%20Files/33040 Android 2026-06-01 security patch level vulnerability details https://source.android.com/docs/security/bulletin/2026/2026-06-01 Poly Voice Possible Remote Control of Certain Poly Devices CVE-2026-0826 https://support.hp.com/us-en/document/ish_15052661-15052687-16/hpsbpy04083 https://www.rapid7.com/blog/post/ve-cve-2026-0826-critical-unauthenticated-stack-buffer-overflow-hp-poly-vvx-trio-voip-phones-fixed/ Security Advisory Ivanti Neurons for ITSM (CVE-2026-9614) https://hub.ivanti.com/s/article/Security-Advisory-Ivanti-Neurons-for-ITSM-CVE-2026-9614?language=en_US My Upcoming Classes https://www.sans.org/profiles/dr-johannes-ullrich

If you've ever wondered why some brands just seem to "stick" while others fade into the noise, the answer might have less to do with budget and more to do with brain science. On this episode of the Agents of Change podcast, I sat down with MichaelAaron Flicker, CEO of XenoPsi Ventures and co-author of Hacking the Human Mind, to dig into the behavioral triggers behind some of the most iconic marketing campaigns in history. The best part? These aren't strategies reserved for Fortune 500 companies. MichaelAaron breaks down exactly how small and mid-sized businesses can put these same psychological principles to work today. https://www.theagentsofchange.com/624 Need help with your branding, website, or digital marketing? Reach out to me (Rich Brooks!) today at https://www.takeflyte.com/contact

Needle-Free Peptides, US Manufacturing, BPC-157, Thymosin Alpha-1, GLP-1s, Microneedle Patches, and How to Avoid Contaminated Peptides Peptides are one of the most powerful tools in biohacking and anti-aging medicine, and until now, most people couldn't access them safely, legally, or without a needle. This episode changes that. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days Host Dave Asprey sits down with Justin Kirkland, a longevity medicine expert with over 30 years in drug development and pharmaceutical innovation. Kirkland holds multiple drug synthesis and formulation patents, has founded multiple pharmaceutical companies, and is one of the few people in the world manufacturing peptides entirely on US soil, controlling every step of the synthesis process from raw amino acids to finished product. If you want to understand what is really inside your peptides and why it matters for your longevity and human performance, he is the person to listen to. Dave and Justin go deep on why most peptides on the gray market contain dangerous residual compounds that can spike liver enzymes and cause real harm, why Chinese-sourced APIs are not always what they claim to be, and how a new generation of needle-free delivery systems including microneedle patches and auto-injectors is making peptide therapy accessible to anyone serious about longevity and human performance. They also cover how AI and functional medicine are converging to make peptide protocols personalized based on genetics and microbiome status, why the thymus gland is one of the most overlooked anti-aging targets in the body, and what the suppression of peptide research reveals about who really controls your access to health tools. You Will Learn: Why many gray market peptides contain toxic residual acids that damage the liver and how to identify clean products How microneedle patches and auto-injectors are replacing traditional injections for peptide delivery Which peptides are most effective for longevity, immune system repair, and human performance including BPC-157, Thymosin Alpha-1, and growth hormone secretagogues Why your genetics and gut microbiome determine whether a peptide will work for you at all How the thymus gland controls your immune system and why it disappears by your mid-20s What the suppression of peptide research tells you about Big Pharma's control over your supplement and nootropics access Why US-manufactured peptides represent a new standard for safety and quality in biohacking How AI is transforming personalized peptide protocols in functional medicine Which peptides are overhyped and which ones actually move the needle on anti-aging and recovery How to store, mix, and dose peptides correctly to avoid the mistakes most people using them are making right now Thank you to our sponsors! - Danger Coffee | Grab yours at DangerCoffee.comand use code DAVEPOD at checkout for 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com DAVE and using code DAVE at checkout. - ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Justin Kirkland, peptides, needle-free peptides, microneedle patch, BPC-157, Thymosin Alpha-1, ipamorelin, CJC-1295, PT-141, KPV peptide, Dihexa, growth hormone secretagogue, peptide purity, TFA contamination, gray market peptides, US manufactured peptides, oral peptides, transdermal delivery, thymus gland, anti-aging, biohacking, longevity, functional medicine, peptide auto-injector, compounding pharmacy Resources: • Go to Aminoinnovations.com and use “asprey20” for a discount through the next 7 days • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro & Guest Welcome 01:55 – Censorship & Platform Bans 06:20 – Peptide Science & Bioavailability 07:20 – Delivery Methods 14:30 – Supply Chain & US Manufacturing 17:01 – Manufacturing Risks & Contamination 24:43 – Peptide Stacks 28:41 – Immune Peptides & Thymus 30:57 – Overhyped Peptides 41:00 – Alternative Delivery (Patches, Nasal, Rectal) 47:25 – Side Effects & Risk 50:30 – Mixing & Storage Tips 54:05 – Wrap-Up & Where to Buy See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Unidentified RAT pushes NetSupport RAT https://isc.sans.edu/diary/Unidentified%20RAT%20pushes%20NetSupport%20RAT/33034 CVE-2026-41089: Windows Netlogon Vulnerability Exploited https://ccb.belgium.be/advisories/warning-microsoft-patch-tuesday-may-2026-patches-118-vulnerabilities-16-critical-102 RedHat npm Packages Affected https://www.aikido.dev/blog/red-hat-npm-packages-compromised-credential-stealing-worm Dashlane Locking Accounts after Brute Force https://status.dashlane.com/pages/5aabcb89fccc4b04d3774443 My Upcoming Classes https://www.sans.org/profiles/dr-johannes-ullrich

Announcing Bitskrieg https://deadeclipse666.blogspot.com/2026/05/announcing-bitskrieg.html Vulnerability in Gogs https://www.rapid7.com/blog/post/ve-authenticated-rce-via-argument-injection-gogs-unfixed/ Oracle Critical Security Patch Update Advisory - May 2026 https://www.oracle.com/security-alerts/cspumay2026.html GlobalProtect Authentication Bypass Vulnerabilities CVE-2026-0257 https://security.paloaltonetworks.com/CVE-2026-0257

I lived with severe brain fog for 15 years. I couldn't focus, my words didn't come easily, and I spent a fortune trying to fix it from the top down...little worked until I realized the problem wasn't in my head—it was in my feet.In this video, I break down the scientifically proven connection between your feet, your circulation, and your cognitive decline. We cover how your brain requires a massive 20% of your body's oxygen to function, and why sitting at a desk all day weakens the calf muscles that act as a "second heart" to pump that oxygenated blood back up to your skull. I also explain how modern cushioned shoes act as sensory deprivation chambers, muffling the critical signals your feet send to your brain. This sensory lack forces your nervous system into a constant, low-level survival state that completely kills your executive function. You don't need another brain supplement to get your mental edge back. You need to fix your foundation. I share the exact barefoot walking and foot-strengthening protocols I used to lift the fog and restore my cognitive sharpness.Thank you to our sponsors!Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off todayEssentia | Go to https://myessentia.com/daveand use code DAVE for $100 off The Dave Asprey Upgrade.iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVETimestamps:00:00 – Personal Experience00:47 – Root Cause: Not in Your Head01:05 – Blood Flow and Brain Function02:10 – The Calf Pump03:52 – Foot Sensory Signals04:26 – Nervous System Impact06:22 – How to Fix It07:51 – Personal ResultsConnect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey's BEYOND Conference: https://beyondconference.com/Dave Asprey's New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Enhanced Games Debut in Las Vegas as the First Openly Drug-Enabled "Biohacker Olympics" The inaugural Enhanced Games took place in Las Vegas with more than 40 elite athletes competing openly while using performance-enhancing drugs, a $25 million prize pool, and a $1 million world record bonus on the table. Host Dave Asprey, who serves on the advisory board of the Enhanced Games, breaks down why this event is less a sports story than a cultural signal: enhancement has moved from underground to prime time, and the institutions that spent decades controlling that conversation through drug testing and bans watched it happen on a stage in Las Vegas. Dave explains why WADA has always existed to protect institutions rather than athletes, why bodily sovereignty is the real issue at the center of this debate, and what it means that even with full transparency about what every athlete was taking, the records didn't fall quite the way you'd expect. The Enhanced Games are the closest thing yet to a public beta test for extreme human enhancement, and the data it generates will matter far beyond sport. Sources: https://www.nytimes.com/athletic/7302319/2026/05/23/enhanced-games-athletes-world-records-doping-steroids/ https://www.npr.org/2026/05/24/nx-s1-5831252/enhanced-games-steroids-olympics-trump https://www.bbc.com/news/articles/cedpz1zqp8po https://www.wusf.org/2026-05-24/the-enhanced-games-are-sunday-heres-what-to-know-about-the-controversial-event Kyle Busch's Death Showed How Severe Pneumonia Can Rapidly Escalate Into Fatal Sepsis NASCAR driver Kyle Busch died after severe pneumonia progressed into sepsis, a condition most people hear about but few truly understand until it is too late. Host Dave Asprey breaks down the biology of what happens when the immune system stops containing an infection and starts attacking the body systemwide, why sepsis can escalate from manageable symptoms to a life-threatening emergency faster than most people expect, and why even someone with great biomarkers and a dialed-in health stack can be blindsided by an acute inflammatory crisis. The warning signs matter: worsening breathing, confusion, rapid decline, and a sense that something is badly wrong are emergency symptoms, not signals to wait and see. Longevity is not only about optimization rituals. It includes knowing when your biology is in crisis and acting before the window closes. Sources: https://www.cnn.com/2026/05/24/health/what-is-sepsis-kyle-busch-wellness https://www.cnn.com/2026/05/26/health/video/sepsis-kyle-busch-medical-care-lead-jake-tapper https://www.michiganmedicine.org/health-lab/nascar-stars-death-shows-how-sepsis-can-kill-anyone-if-not-caught https://www.huffpost.com/entry/what-is-sepsis-kyle-busch_l_6a15a9c1e4b0ddcc84641f34 Menin Loss in the Hypothalamus May Be a Central Switch That Accelerates Aging New research in mice found that a protein called Menin in the hypothalamus may function as a central coordinator of biological aging across the whole body. When Menin declined, aging accelerated. When researchers restored it in older mice, memory improved and lifespan increased. Host Dave Asprey explains why this finding challenges the dominant wear-and-tear model of aging, what it means that the hypothalamus may be running a coordinated aging program rather than simply accumulating damage over time, and why a control-room model of aging points toward fundamentally different intervention strategies than chasing downstream symptoms like fatigue and memory loss. The research connects aging to neuroinflammation, which has direct implications for how biohackers think about hypothalamic health right now. It is still animal research, but the mechanistic case is strong and the implications for longevity science are significant. Sources: https://www.sciencedaily.com/releases/2026/05/260524012959.htm https://www.news-medical.net/news/20230323/Menin-protein-protects-against-aging-and-cognitive-decline.aspx https://www.eurekalert.org/news-releases/982100 https://www.eurekalert.org/news-releases/1116021 IL-6 Blockade With Tocilizumab Showed Early Promise for Treatment-Resistant Depression A small pilot randomized trial tested tocilizumab, an anti-inflammatory drug that blocks IL-6 signaling, in people with difficult-to-treat depression and found remission rates of 54% versus 31% with placebo. Host Dave Asprey breaks down why this result reframes depression as an immune biology problem for a meaningful subset of patients rather than a purely neurochemical one, and why the same inflammatory pathway that drives joint destruction in rheumatoid arthritis is showing up in the brains of people who don't respond to antidepressants. The practical implication is not to seek out a biologic drug off-label. It is to recognize that persistent low mood, fatigue, and low resilience may warrant a deeper biological workup than standard screening provides, starting with IL-6, CRP, and a full inflammatory panel. The brain is downstream of the immune system more than most psychiatry has been willing to admit, and this trial is the clearest evidence yet of why that matters. Sources: https://www.bristol.ac.uk/news/2026/may/pilot-trial-suggests-anti.html https://www.eurekalert.org/news-releases/1128678 https://www.medicalxpress.com/news/2026-05-trial-anti-inflammatory-drug-difficult.html https://clinicaltrials.gov/ New Science Paper Says Intrinsic Human Lifespan May Be About 50% Heritable A paper published in Science argues that the genetic contribution to human lifespan is roughly 50% heritable, far higher than previous estimates, once researchers correct for deaths caused by accidents, infections, and external causes unrelated to aging biology. Host Dave Asprey explains why this finding is liberating rather than deterministic, what it means that genetics loads the dice on lifespan more than the mainstream has been willing to admit, and why personalized longevity strategy matters far more than generic population-level advice. Your genes load the dice but you still roll them. The study pushes the field toward genetic stratification and biomarker-based personalization, and it validates the core premise that the same intervention will not produce the same outcome in every person. Get your genetics tested and build your strategy from your own baseline, not from what worked for the average person in a study. Sources: https://www.science.org/doi/10.1126/science.adz1187 https://pubmed.ncbi.nlm.nih.gov/41610249/ https://www.nature.com/articles/d41586-026-00300-w https://www.eurekalert.org/news-releases/1113892 This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on human enhancement, acute inflammatory risk, neuroendocrine aging, immune-driven depression, and the genetics of lifespan. Host Dave Asprey connects emerging clinical research, real-world performance culture, and actionable optimization frameworks into a clear picture of where biology actually drives outcomes and where most people are still managing symptoms instead of finding the mechanism. New episodes every Tuesday, Thursday, Friday, and Sunday. Keywords: Enhanced Games biohacking, performance enhancement bodily autonomy, WADA elite sport doping, Kyle Busch sepsis death, pneumonia sepsis escalation, sepsis warning signs, Menin hypothalamus aging, brain aging master switch, neuroendocrine aging longevity, tocilizumab depression IL-6, inflammation treatment-resistant depression, immune biology mental health, lifespan heritability genetics, longevity genetics personalization, genetic stratification healthspan, biohacking news 2026, longevity research 2026, healthspan optimization, inflammation testing CRP IL-6 Thank you to our sponsors! - HeartMath | Go to https://www.heartmath.com/dave to save 15% off. - The One Device | Use code DAVE for $10 off at theonedevice.com/dave - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Resources: • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Intro 00:38 – Story 1: Enhanced Games 01:49 – Story 2: Kyle Busch Death (Sepsis) 03:09 – Story 3: Menin Protein and Brain Aging 04:37 – Story 4: Inflammation and Depression 06:20 – Story 5: Lifespan Heritability 07:47 – Takeaway See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

How CD38, PARP, and Leaky Gut Are Destroying Your NAD Levels | Dr. Andrew Salzman Your NAD is being drained by two hidden enzymes, your gut may be the starting point of every aging process in your body, and creatine does something to your mitochondria that has nothing to do with muscle. This episode rewrites what you thought you knew about longevity, anti-aging biology, and how your body actually produces and delivers energy at the cellular level. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR -Explore all of Wonderfeel's products at: getwonderfeel.com/dave They are gifting a complimentary 7-day Youngr™ supply (mini pouch) with every order across any of their products. The code will be DAVE, and the campaign will be active through June 6th. Host Dave Asprey sits down with Dr. Andrew Salzman, a physician, inventor, and biomedical entrepreneur with more than 30 years of experience in drug discovery and development. An alumnus of Harvard Medical School, Yale University, and Columbia University, Dr. Salzman has authored more than 170 scientific publications and holds 50 patents. He invented the original clinical-stage PARP-1 inhibitor, leading to the world's first clinical treatment for raising NAD levels and fighting cancers caused by the BRCA1 and BRCA2 genes. Genentech licensed his breakthrough technology for $600 million. His research into gastrointestinal microbiota, autoimmune disease, oxidative stress, and mitochondrial ATP production now forms the foundation of how millions of patients get treated worldwide. Dr. Salzman names the two biggest NAD drains in your body, CD38 and PARP, and explains why taking NMN or NR alone is like filling a bathtub with the drain wide open. He breaks down the formulation science behind pairing NAD precursors with CD38 blockers like hydroxytyrosol alongside PARP-reducing antioxidants like ergothioneine, and delivers a paradigm-shifting explanation of creatine as an energy distribution network inside your cells. Rather than a simple muscle supplement, creatine acts as a high-speed ATP shuttle that carries energy from your mitochondria to the precise location and moment your brain, gut, and heart need it most. You'll Learn: Why NAD declines with age and which two enzymes are primarily responsible for draining it How CD38 rises with inflammation rather than NAD levels, and what that means for your supplement strategy Why creatine is one of the most underrated anti-aging and brain optimization supplements available How creatine functions as a spatial and temporal energy delivery network for your brain, gut, and heart Why the gut may be the origin point of the entire aging process and how that cascade unfolds decade by decade How leaky gut drives systemic inflammation, crashes NAD, and accelerates biological aging throughout the body What controls tight junction integrity and how ATP, butyrate, creatine, and fasting all play a role Why most creatine supplements fail to absorb properly and what to look for in a high-quality source How to rebuild your microbiome in three to four weeks through diet alone, without antibiotics Why walking immediately after a meal may be doing more harm than good to your gut lining Thank you to our sponsors! - Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave. - KILLSwitch | If you're ready for the best sleep of your life, order now at https://www.switchsupplements.com/and use code DAVE for 20% off - Pique | Go to Piquelife.com/dave for 20% off. - iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Dr. Andrew Salzman, NAD depletion, CD38 inhibition, PARP inhibition, NMN supplements, creatine ATP shuttle, leaky gut aging, tight junction integrity, inflammaging, lipopolysaccharide gut, flagellin toxin, butyrate gut healing, ergothioneine, hydroxytyrosol, peroxynitrite, superoxide mitochondria, creatine energy distribution, gut origin of aging, NAD bathtub analogy, BRCA PARP inhibitor, Wonderfeel, creatine monohydrate, intestinal permeability, microbiome butyrate, selective digestive decontamination, TMAO nitric oxide Resources: • Explore all of Wonderfeel's products at: getwonderfeel.com/dave • Order Youngr™: getwonderfeel.com/dave• Order ChocoCreatin™: getwonderfeel.com/dave• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Trailer 01:12 – Introduction & BRCA Background 02:19 – DNA Damage & PARP 04:38 – Free Radicals & Oxidative Stress 11:37 – NAD & Antioxidant Defense 12:34 – CD38 & NAD Depletion 23:31 – The Gut-Aging Hypothesis 30:05 – ATP, Creatine & Energy Distribution 36:41 – Creatine as Energy Shuttle 51:09 – Microbiome & Gut Repair 59:21 – TMAO & Nitric Oxide Interference 1:03:52 – Flagellin & Gut Inflammation Research 1:09:45 – FDA & Pharmaceutical Incentives 1:16:05 – Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.