Podcast appearances and mentions of matt kaeberlein

The longevity space is exploding—with new drugs, supplements, influencers, and bold promises appearing almost daily. But what actually holds up under scientific scrutiny?In this rapid-fire return to The Aging Well Podcast, Dr. Jeff Armstrong welcomes back Dr. Matt Kaeberlein, one of the world's leading researchers in the biology of aging. Together, they move quickly through a curated list of popular longevity drugs and supplements—asking what works, what's overhyped, what's promising but premature, and what may carry real risk.They also discuss how to evaluate so-called “longevity experts,” how to think about evidence in an emerging field, and what Dr. Kaeberlein is personally doing right now to optimize his own healthspan. The episode closes with a thoughtful conversation on psilocybin—where it may fit in mental health, and whether it has any legitimate role in longevity science.This is a clear-eyed, intellectually honest tour through the modern longevity landscape.Please, support The Aging Well Podcast by hitting the ‘like' button, subscribing/following the podcast, sharing with a friend, and….Tip Jar! All donations support this podcast to keep it going. https://paypal.me/theagingwellpodcastBUY the products you need to… age well from our trusted affiliates and support the mission of The Aging Well Podcast*.The Aging Well Podcast merchandise | Show how you are aging well | Use the promo code AGING WELL for free shipping on orders over $75 | https://theagingwellpodcast-shop.fourthwall.com/promo/AGINGWELLAuro Wellness | Glutaryl—Antioxidant spray that delivers high doses of glutathione (“Master Antioxidant”) and the new Copper Tripeptide (GHK-Cu) | 10% off Code: AGINGWELL at https://aurowellness.com/agingwellpodcastNutritional Biochemical Inc. (NBI) | Trusted supplement. NBI stands 100% behind the quality of their formulations and the science on which they're based. | Click the following link and use the discount code AGINGWELL for 10% off: https://shop.nbihealth.com/agingwellBerkeley Life | Optimize nitric oxide levels | Purchase your starter kit at a 15% discount | Use the promo code: AGINGWELL15 | https://berkeleylife.pxf.io/c/6475525/3226696/31118Oxford Healthspan | Primeadine®, a plant-derived spermidine supplement | 10% off code: AGINGWELL | https://oxford-healthspan.myshopify.com/AgingWellJigsaw Health | Trusted supplements. “It's fun to feel good.” | Click the following link and use the discount code AGINGWELL for 10% off: https://www.jigsawhealth.com/?rfsn=8710089.1dddcf3&utm_source=refersion&utm_medium=affiliate&utm_campaign=8710089.1dddcf3KneeMo | A smart device programmed to reduce your knee pain and keep you moving. | Click the following link and use the discount code AGINGWELL15 for 15% off: https://thekneemo.com/ref/agingwellProlon | The Fasting Mimicking Diet (FMD) is a revolutionary five-day nutrition program scientifically formulated to mimic the effects of a prolonged water fast while still allowing nourishment - supporting the benefits of fasting without the challenges and risks that come from water-only fasts. | For the best available discount always use this link: https://prolonlife.com/theagingwellpodcastL-Nutra Health | The medical division of L-Nutra, focused on helping people manage and potentially reverse chronic health conditions, like type 2 diabetes, prediabetes, insulin resistance, and obesity, using personalized, lifestyle-based programs grounded in evidence, not prescriptions. | Use this link: https://l-nutrahealth.com/theagingwellpodcastDr Lewis Nutrition | Fight neurodegeneration and cognitive decline with Daily Brain Care by Dr Lewis Nutrition—a proven daily formula designed to protect and restore brain function. | 10% off code: AGINGWELL or use the link: https://drlewisnutrition.com/AGINGWELL*We receive commission on these purchases. Thank you.

What if you had more control over your brain's future than you think? Dr. Tommy Wood, neuroscientist, Associate Professor of Pediatrics at the University of Washington, and head of science for motorsport at Hintsa Performance, joins Dr. Matt Kaeberlein to discuss his new book, The Stimulated Mind. From the science of neuroplasticity to the real drivers of dementia prevention, this episode is packed with evidence-based, actionable insight.Timestamps:0:00 — Introduction: Brain fog, burnout & why our brains feel under strain1:42 — Age-specific dementia incidence has been declining — why no one talks about it2:05 — Why Dr. Wood wrote The Stimulated Mind4:59 — Dr. Wood's background: Cambridge, Oxford, Oslo, and UW8:30 — How a PhD in neonatal brain injury led to elite athlete performance work11:20 — The Keto CTA Trial: ApoB, LDL, and plaque formation on a ketogenic diet15:50 — Can you still have metabolic dysfunction on a long-term keto diet?17:17 — What the keto trial actually found — and why the original results were retracted23:53 — Working with Formula One drivers: biomarkers, blood panels & performance29:51 — Magnesium: is everyone actually deficient?30:33 — The zinc-copper problem in athletes — and why B6 stacks up in their blood34:03 — Why elite athletes use fewer supplements than you'd expect35:19 — Sleep tracking with wearables: HRV, respiratory rate & what actually predicts performance39:53 — Why Dr. Wood wrote The Stimulated Mind (deeper dive)42:16 — Dementia: confluence of factors, individual trajectories & the Lancet projections44:23 — GLP-1s, metabolic disease & shifting dementia projections49:00 — The adult brain is NOT fixed: neuroplasticity across the lifespan52:44 — Is promoting neuroplasticity always beneficial? TMS and the "sledgehammer" problem57:02 — Exercise as a neuroplasticity tool: the 20–30 minute jog protocol58:26 — Arousal, the Yerkes-Dodson curve & how mistakes drive learning1:01:17 — Cold exposure, bright light & breathwork as arousal tools1:04:11 — Psilocybin and neuroplasticity: therapeutic promise vs. open questions1:06:39 — Can grief induce neuroplasticity? An unexpected connection1:08:03 — The 3S Model: Stimulus, Supply & Support for brain health1:15:26 — Education, cognitively stimulating jobs & making up for early deficits1:17:49 — The ACTIVE Study: the brain training game with 20-year dementia data1:23:31 — Video games, exercise & what's actually building cognitive reserve1:25:03 — Supply: why cardiovascular and metabolic health are critical for the brain1:26:29 — Key nutrients for brain health: omega-3s, B vitamins, vitamin D & iron1:27:14 — The Vitacog study: why omega-3 index and homocysteine must be optimized together1:29:59 — PDE5 inhibitors (Viagra/Cialis) and dementia risk — what the data says1:32:30 — Cognitive supplements: what actually has evidence (and what doesn't)1:35:41 — Rapamycin and cognitive function: cerebral blood flow & immune resilience1:38:43 — The best exercise for your brain: Zone 2, HIIT, resistance training & sport1:44:34 — Nutrition strategy for cognitive aging: whole foods, polyphenols & berries1:47:46 — Support: sleep, trophic factors & hormonal health1:48:31 — Testosterone, estrogen & menopause: what hormone therapy can and can't do for the brain1:52:21 — Air quality, chronic stress & environmental exposures as dementia risk factors1:54:19 — Chronic stress as "overtraining" for the brain

``I think we know enough today for the average person to gain close to 2 decades of heathy life." There is a lot of hype in the longevity space, mainly generated by influencers. For non-specialists it can sometimes be difficult to know which information to trust, particularly when it comes to supplements and medications. In this conversation I speak with biologist and biogerontologist Matt Kaeberlein. My goal with the discussion was to better undrestand what scientists really know about aging and living longer, and to seperate out the science from the hype. We discuss lifestyle factors, known medications, the influence of testosterone and genetics, as well as some of the more interesting treatments being explored today. We also touch on some of Matt's reseach in the area of drug discovery. ►Watch on YouTube: https://youtu.be/Q5ZOc_UzF1U ►You can find out more about Matt's work here: https://halo.dlmp.uw.edu/people/matt-kaeberlein/ https://www.optispan.life/  

Dr. Matt Kaeberlein and Clinical Director Dr. Nicki Byrne tackle your most pressing supplement questions in this AMA episode, cutting through the hype to give you science-backed answers you can actually use. From CoQ10 and statins to sulforaphane influencer hype, creatine and kidney disease, and why a popular longevity doctor may be losing Matt's trust, this episode covers a lot of ground. If you've ever wondered which supplements are worth your money and which ones belong in the trash, this one's for you.Timestamps:00:00 — Cold open highlights01:18 — Episode intro: AMA focused on supplements01:57 — CoQ10: Does it help with statin-induced muscle pain?04:43 — Is there any reason to take CoQ10 on its own?05:23 — Taurine: Promising or overhyped?07:35 — Astaxanthin: What the evidence actually shows09:45 — Why supplement research is structurally flawed11:05 — Creatine for plant-based dieters12:22 — Creatine and kidney disease: What the data says15:48 — Matt, Nicki & Nick's current creatine doses17:00 — Vitamin D: Reference ranges vs. optimal ranges18:57 — Vitamin K2: Bone density, vascular calcification & dosing caution21:55 — Sulforaphane: Great biology, limited evidence, too much hype27:21 — Resveratrol, hormesis & plant defense chemicals27:58 — Fish oil & the omega index: Why Matt supplements even though he eats fish29:23 — Mark Hyman, sirtuins & the problem with longevity influencers32:08 — Lithium & SGLT2 inhibitors: Matt adjusts his dose live34:15 — Is lithium orotate safe? Addressing the liver carcinogen concern36:26 — Is there an OTC alternative to rapamycin?37:40 — Berberine vs. metformin: More similar than you think38:58 — What do Matt, Nicki & Nick actually take?41:48 — Wrap-up & teaser: Deep dive on magnesium coming soon

The Galleri multi-cancer detection test made headlines when its landmark NHS trial failed to meet its primary endpoint, sending Grail's stock down nearly 50%. But does that mean Galleri is useless? Not exactly. In this episode, Dr. Matt Kaeberlein breaks down what the NHS Galleri trial actually measured, why missing a primary endpoint doesn't tell the whole story, and what the results mean for three distinct groups: the general population, high-risk individuals, and people considering the test for themselves.Timestamps:0:00 — What is Galleri? Multi-cancer detection explained0:44 — Would Dr. Kaeberlein take the test? ($1,000 question)1:29 — Episode overview: defense, takedown, or something else?2:30 — How Galleri works: circulating tumor DNA and methylation3:23 — The core promise: early detection across 50+ cancer types4:20 — The NHS Galleri trial: 140,000 participants, 3 years5:15 — Trial results, the press release spin, and the stock drop5:59 — How OptiSpan currently uses Galleri in practice6:43 — Pre-trial take: not ready for population screening, but why?7:32 — The real risks: false positives, false negatives, and downstream consequences9:05 — What it takes to justify population-level screening10:48 — Inside the NHS trial design12:40 — Why the trial was set up to be difficult from the start13:29 — What the positive signals in the data actually suggest15:49 — High-risk individuals: does Galleri make sense for them?17:38 — Individual-level decision-making: what you need to consider18:33 — Sensitivity and specificity explained plainly22:07 — Walking through the math: false positives in the real world24:20 — Retesting after a positive signal: an open question25:00 — Sensitivity by cancer stage and aggressiveness25:45 — Final verdict: does Galleri have clinical value?27:25 — Dr. Kaeberlein's personal decision on taking the test

What if menopause is one of the most important longevity events in human biology, and we've been ignoring it?Dr. Matt Kaeberlein sits down with Dr. Jennifer Pearlman, founder of PearlMD and pioneer in female-centric longevity medicine, to unpack why women's health has been systemically underfunded, undertreated, and misunderstood and what a proactive approach actually looks like.From the flawed science behind the Women's Health Initiative to the nuts and bolts of hormone optimization, testosterone for women, and the emerging field of ovarian tissue cryopreservation, Dr. Pearlman brings 20+ years of clinical expertise and a framework she calls FemSpan: harnessing the unique biology of female longevity while mitigating the risks most medicine ignores.Timestamps:00:00 — Cold open00:47 — Welcome & Dr. Pearlman's origin story02:33 — Why the medical system fails women08:37 — How the women's health landscape has shifted over 20 years09:26 — The Women's Health Initiative: what went wrong13:07 — What drove the reemergence of menopause medicine14:38 — Big Pharma, funding, and the micronized progesterone question17:13 — "Medicine progresses one funeral at a time"18:01 — From functional medicine to precision medicine20:35 — Rebranding aging: from anti-aging to longevity23:50 — Navigating the gray zone between frontier and fringe27:46 — How to identify credible practitioners33:32 — What every woman should know about the menopause transition36:41 — Why take a proactive approach? Symptoms, disease risk, and aging38:19 — The two simultaneous biology processes of menopause41:46 — The role of FSH and hormone optimization43:28 — Estradiol as the body's regenerative signal47:24 — What to test and when50:38 — The metabolic theory of menopause55:08 — Visceral fat as an evolutionary adaptation57:26 — How to navigate hormone therapy01:00:24 — Bioidentical hormones: reclaiming the term01:06:45 — Why route of administration matters01:11:35 — Progesterone: the unsung hero of menopause management01:23:19 — Testosterone for women: what the science actually says01:34:25 — Introducing FemSpan: the female longevity framework01:37:55 — The biological aging advantages women carry01:46:46 — Can we close the healthspan gap?01:53:05 — Could reversing menopause extend female lifespan?02:00:29 — Regenerative medicine and the future of female longevity02:03:10 — Ovarian tissue cryopreservation explained02:10:39 — AI in women's precision medicine02:15:50 — Medicine at scale: opportunity and risk02:21:41 — Advanced cardiovascular diagnostics and the female gap02:24:22 — Closing thoughts: your aging trajectory is more in your control than you think

Links to All Articles Mentioned:https://www.fda.gov/drugs/human-drug-compounding/certain-bulk-drug-substances-use-compounding-may-present-significant-safety-riskshttps://www.fda.gov/media/174456/downloadRFK Jr. just appeared on the Joe Rogan podcast and peptides were front and center. Dr. Matt Kaeberlein breaks down the conversation in real time, fact-checking claims about peptide efficacy, FDA regulation, and the growing black market for compounded peptides.What does the science actually say? What did RFK get right and where did the conversation miss the mark? Dr. Kaeberlein cuts through the noise with a scientist's lens, covering everything from BPC-157 to GLP-1 agonists to the FDA's Category 2 bulk drug substances list.If you're navigating the peptide space and want clarity over hype, this one's for you.Timestamps:00:00 — Intro & Episode Overview01:06 — RFK on Joe Rogan: The Peptide Conversation Begins02:06 — First Fact Check: "We Know Peptides Work"03:50 — GLP-1 Agonists: The Exception, Not the Rule05:05 — RFK's Personal Peptide Experience06:32 — The FDA's Bulk Drug Substances List Explained08:32 — FDA Category 2: What It Actually Means09:21 — The Peptides That Were Banned From Compounding10:18 — Did the FDA Consider Safety? Here's What the Data Says12:03 — Real Cases of People Harmed by Compounded Peptides13:40 — Can the FDA Consider Efficacy? Reading Directly From the Guidelines15:44 — The Peptide Black Market: How It Emerged17:54 — Will Reversing the Ban Actually Fix the Problem?19:20 — RFK's Push to Move 14 Peptides Back to the Bulk List20:16 — Dr. Kaeberlein's Take: Informed Patient Access Matters21:51 — Who Created the Black Market?22:46 — What Would Actually Help: Funding Real Clinical Trials23:36 — Final Thoughts & Call to Action

What does over 18 months of precision medicine actually look like in practice? In this episode of the Optispan Success Story Series, Dr. Matt Kaeberlein sits down with Carlos Pinto, a tech executive and early Optispan client, to trace his longitudinal health journey from metabolic warning signs to measurable, sustained transformation. Carlos shares how a decade of overlooked biomarkers, a post-pandemic health decline, and a single panic attack became the catalyst for a data-driven approach to his own biology. Together, he and Dr. Kaeberlein review real DEXA, lipid, metabolic, and environmental biomarker data, unpacking what moved the needle, what didn't, and why the answer was rarely simple. This conversation is a candid look at what it means to become your own best health advocate, not through quick fixes, but through personalized, longitudinal learning.Timestamps:0:00 – Cold open & highlights0:50 – Welcome & Carlos's background in tech leadership2:15 – How career ambition displaced health in his 20s and 30s3:39 – A panic attack as the turning point: connecting mental and physical health4:24 – A previous medical wellness program: what worked and what was missing6:34 – Arriving at OptiSpan: intention, mindset, and expectations7:15 – Gateway Day: comprehensive baseline testing and initial surprises8:51 – Early metabolic lessons: CGM data, glucose spikes, and dawn effect11:32 – Confronting white coat hypertension with 78 data points13:28 – How stress, sleep, and nutrition interact to drive metabolic dysfunction15:44 – Personal experimentation as methodology: berberine, time-restricted eating, and fish17:09 – Mercury toxicity from fish consumption: a case study in biomarker surveillance18:33 – Stress management protocols: walking, meditation, and measurable outcomes19:49 – Statin introduction: the role of medication as a tool, not a failure20:27 – DEXA results: visceral fat reduction, body fat loss, and lean mass gain24:17 – Lipid profile transformation: ApoB from ~115 to 70, LDL from 160 to 7425:57 – A1C trajectory and the complexity of glucose optimization30:01 – Reframing medication: proactive use vs. reactive disease management31:29 – Mercury biomarker deep dive: from 2.4 to 16 and back to 232:21 – Goals for the future: sustainability, muscle retention, and mental clarity36:30 – Lineage biological age algorithm: from mortality risk of 54 to 5239:27 – Closing reflections: health as a lifelong trajectory, not a program

Peptides are everywhere in longevity and functional medicine, but what does the law actually say? In this episode, Dr. Matt Kaeberlein breaks down what a peptide is and the complex regulatory landscape governing peptides in the United States, from FDA approval frameworks to the legal gray zones surrounding compounding pharmacies and unapproved substances.Drawing on the Federal Food, Drug, and Cosmetic Act and real-world enforcement cases, this episode offers a clear-eyed, non-judgmental examination of what is legal, what is tolerated, and what carries genuine risk for physicians, pharmacies, and patients alike. An essential listen for anyone navigating the rapidly evolving world of peptide therapeutics.Timestamps:00:00 — The Tailor Made Compounding Case: Criminal Prosecution & FDA-Flagged Peptides00:54 — Welcome & Episode Overview: The Regulatory Environment of Peptides01:36 — What Is a Peptide? Definitions and Biological Context03:26 — Are Peptides Regulated by the FDA?04:16 — Two Regulatory Frameworks: Biologics vs. Chemically Synthesized Drugs05:17 — The Food, Drug, and Cosmetic Act: Which Peptides Fall Under It?06:11 — Why Two Frameworks Exist: A Brief Legislative History07:06 — The Core Rule: FDA Approval vs. Unapproved Status07:54 — FDA-Approved Peptides: What Can Legally Be Prescribed09:11 — Compounding Pharmacies: When Is It Legal?10:01 — The Unapproved Peptide Bucket: A Long List10:55 — Legal Status of Unapproved Peptides Under U.S. Law12:34 — The Bulk Drug Substances List: What It Is and What It Isn't14:11 — FDA's "Significant Safety Risk" Flagged Peptides15:04 — Why Some Pharmacies Still Compound Unapproved Peptides16:44 — The Gray Area: Speeding Analogies and Cultural Norms17:38 — Degrees of Risk: Formulation, Approval Status, and Data Quality18:38 — Who Bears Legal Liability? Pharmacies, Physicians, and Patients19:39 — The Tailor Made Compounding Case: DOJ Action and Criminal Conviction20:34 — Risk to Physicians and Patients Summarized21:24 — Self-Sourcing Peptides Online: What Consumers Should Know22:14 — Prescription Drugs Without a Prescription: Legal Nuance23:06 — Final Thoughts: The State of Peptide Medicine Today23:58 — How Enforcement Norms Can Shift and Why It Matters Now24:48 — Questions to Ask Yourself: Risk Tolerance and Physician Choice25:21 — An Informed Consent Framework for Peptide Use26:03 — Coming Up: Individual Peptide Deep-Dives in Future Episodes

On this episode, Dr. Matt Kaeberlein is joined by Noah Neiman, co-founder of Rumble Boxing and founder of Knuckle Therapy. From panic attacks and rock bottom to building global fitness brands, Noah and Matt explore the profound connection between physical training and mental resilience. Noah shares how structured movement became the foundation for managing ADHD, anxiety, and depression, and why the discipline of fight training translates directly into how we navigate life's hardest moments. A candid conversation on the neuroscience of presence, the therapeutic power of service to others, and what it truly means to train for longevity, in the ring and beyond.Timestamps:00:00 — Introduction & Cold Weather in New York01:04 — Pittsburgh Roots, Sports, and Life Metaphors02:22 — How Training Saved Noah's Life03:05 — ADHD, Physical Control, and Emotional Regulation04:36 — Early Influences: Boxing Gyms, Body for Life, and Therapy06:28 — Football, Identity, and Taking Control of the Body07:02 — College, Jiu-Jitsu, and Finding Purpose08:08 — Anxiety, Depression, and the Power of Presence09:22 — What "Training" Really Means: Sleep, Nutrition, and Mindset10:36 — How You Train Is How You Fight Is How You Live13:30 — The Turning Point: Giving to Others as Therapy14:10 — Selling Drugs, Materialism, and Misery15:23 — Muhammad Ali, Service, and Spiritual Rent17:23 — Failing Upwards: The Road to Barry's Bootcamp19:46 — Warren Stout, Jiu-Jitsu, and Rebuilding After Near-Overdose21:19 — The Craigslist Apartment and Moving to New York22:27 — Walking Into Barry's Bootcamp for the First Time25:44 — Vampire Fitness Hour: Building a Brand from One Class27:47 — Teaching Through Panic Attacks and Overcoming Them28:57 — Medication, Anxiety, and Finding the Root Cause31:12 — The Tattoo, King Henry VI, and "Fearless Minds"32:30 — The Birth of Rumble Boxing36:54 — Co-founding Rumble with Eugene Ram38:09 — Pandemic, Selling Rumble, and What Comes Next40:07 — Launching The Pack: Three Dogs, Three Modalities47:07 — Knuckle Therapy: Honoring Oz and Building a Brand52:55 — A Typical Week: Exercise, Walking, and Movement55:17 — Training at Henzo Gracie's and Teaching Daily57:03 — Recovery, Injury Prevention, and Longevity at 4101:02:37 — Nutrition: Eating a Lot, Eating Clean01:06:46 — Sleep, Balance, and Living in the Extremes01:11:43 — The Most Unexpected Part of the Journey01:16:24 — Advice for Anyone Going Through It01:19:46 — Choose Love, Not Fear: Closing Thoughts

This episode dives into the future of longevity, healthspan, and proactive healthcare with Dr. Matt Kaeberlein, a world-renowned longevity expert and CEO of Optispan. He shares his unlikely "comic book origin story," from playing in rock bands and working blue-collar jobs to becoming a leading scientist at MIT and a founder of multiple longevity initiatives including the Dog Aging Project. The conversation breaks down the difference between lifespan and healthspan, why lifestyle "four pillars" (eat, move, sleep, connect) matter most, and how simple shifts like cutting ultra-processed foods can dramatically improve long-term vitality. Dr. Kaeberlein also explores the promise and pitfalls of AI in healthcare, why longevity is not just for billionaires, and how Optispan aims to use advanced diagnostics and personalized, science-backed care to reclaim 10–20 years of higher-quality life for everyday people. Along the way, he gives pragmatic takes on GLP‑1 drugs, creatine, supplements, microplastics, and the mindset shift of "choose love, not fear" as a guiding principle for a longer, better life.   Dr. Kaeberlein is also the host of The Optispan Podcast, a top-rated show with tens of thousands of loyal listeners. Through both the podcast and his growing Instagram presence (@mkaeberlein), he breaks down complex topics—from gut health to cellular aging—bringing scientific clarity to a crowded wellness landscape.   Is there a guest you want Equalman to interview on the podcast? Do you have any questions you wish you could ask an expert? Send an email to our team: Equalman@equalman.com   5x #1 Bestselling Author and Motivational Speaker Erik Qualman has performed in over 55 countries and reached over 50 million people this past decade. He was voted the 2nd Most Likable Author in the World behind Harry Potter's J.K. Rowling.   Have Erik speak at your conference: eq@equalman.com   Motivational Speaker | Erik Qualman has inspired audiences at FedEx, Chase, ADP, Huawei, Starbucks, Godiva, FBI, Google, and many more on Focus and Digital Leadership.   Learn more at https://equalman.com

How much do we really know about ageing? For decades, scientists have been trying to understand the biology of the ageing process - what happens to our bodies as we get older? And is it possible to slow that process down or even stop it all together?In this series of Tech Tonic, the FT's Hannah Kuchler and Michael Peel look into the past, present and future of longevity - the wellness movement focused on extending and bettering your quality of life. Episode 1 follows Hannah as she speaks with UCL professor David Gems about the history of ageing research, and then with longevity researcher Matt Kaeberlein to discuss how the industry has developed - including current drugs that could have anti-ageing effects. Plus, Michael visits the Reviv clinic in London where he experiences, first hand, the growing consumer interest in the longevity craze. To listen to the rest of the series, find Tech Tonic on your favourite podcast platform by clicking here!Clips: @DaveAspreyBPR, @drjoshaxe, @HealthCoachKait, Hevolution, Pom, Purina, Garnier, 4G antioxidants, @ChrisWillx, @lexfridman, ABC News, C-Span, CBS, ITV This Morning, Wired UK, The Dissenter, Will TennysonThe FT does not use generative AI to voice its podcasts. Hosted on Acast. See acast.com/privacy for more information.

How much do we really know about ageing? For decades, scientists have been trying to understand the biology of the ageing process - what happens to our bodies as we get older? And is it possible to slow that process down or even stop it all together?In this series of Tech Tonic, the FT's Hannah Kuchler and Michael Peel look into the past, present and future of longevity - the wellness movement focused on extending and bettering your quality of life. Episode 1 follows Hannah as she speaks with UCL professor David Gems about the history of ageing research, and then with longevity researcher Matt Kaeberlein to discuss how the industry has developed - including current drugs that could have anti-ageing effects. Plus, Michael visits the Reviv clinic in London where he experiences, first hand, the growing consumer interest in the longevity craze. To listen to the rest of the series, find Tech Tonic on your favourite podcast platform by clicking here!Clips: @DaveAspreyBPR, @drjoshaxe, @HealthCoachKait, Hevolution, Pom, Purina, Garnier, 4G antioxidants, @ChrisWillx, @lexfridman, ABC News, C-Span, CBS, ITV This Morning, Wired UK, The Dissenter, Will TennysonThe FT does not use generative AI to voice its podcasts. Hosted on Acast. See acast.com/privacy for more information.

How much do we really know about ageing? For decades, scientists have been trying to understand the biology of the ageing process - what happens to our bodies as we get older? And is it possible to slow that process down or even stop it all together?In this series of Tech Tonic, the FT's Hannah Kuchler and Michael Peel look into the past, present and future of longevity - the wellness movement focused on extending and bettering your quality of life. Episode 1 follows Hannah as she speaks with UCL professor David Gems about the history of ageing research, and then with longevity researcher Matt Kaeberlein to discuss how the industry has developed - including current drugs that could have anti-ageing effects. Plus, Michael visits the Reviv clinic in London where he experiences, first hand, the growing consumer interest in the longevity craze. Read more from the FT — for free: My year-long quest to live foreverThe quest to make young blood into a drug Muscly people show slower brain ageing, study findsThis season of Tech Tonic is presented by Hannah Kuchler and Michael Peel. It was produced by Josh Gabert-Doyon. The senior producer is Edwin Lane. Flo Phillips is the executive producer. Sound design by Breen Turner and Samantha Giovinco. Fact checking by Simon Greaves, Lucy Baldwin and Tara Cromie. Original music by Metaphor Music. Manuela Saragosa is the FT's acting co-head of audio.Clips: @DaveAspreyBPR, @drjoshaxe, @HealthCoachKait, Hevolution, Pom, Purina, Garnier, 4G antioxidants, @ChrisWillx, @lexfridman, ABC News, C-Span, CBS, ITV This Morning, Wired UK, The Dissenter, Will TennysonThe FT does not use generative AI to voice its podcasts.Read a transcript of this episode on FT.com Hosted on Acast. See acast.com/privacy for more information.

Longevity scientist Dr. Andrew Steele sits down with Dr. Matt Kaeberlein to make the provocative case that aging should be treated as humanity's greatest challenge, even bigger than climate change. In this deep conversation, they explore why two-thirds of all deaths are caused by aging, the cutting-edge science that's already extending healthy lifespan in animals, and what it would really mean to add decades of vitality to human life. From CRISPR gene therapies to senescent cell clearance, from the ethics of radical life extension to practical steps you can take today, this is an unflinching look at whether we can (and should) slow down aging itself.Timestamps00:00 – Why Aging Is the Biggest Problem We're Not Solving01:33 – Is Aging Actually Fixable? What the Science Shows04:01 – Overpopulation Myths vs. Longevity Reality09:02 – Can We Slow Aging? What's Working Now14:39 – Inside the Longevity Divide: Hope vs. Hype18:45 – Healthspan vs. Lifespan: What Really Matters29:12 – Chronic Disease and the True Cost of Aging36:21 – The Most Promising Longevity Therapies Today56:56 – Biological Age Tests: What You Can Actually Trust01:53:17 – The Future of Longevity: AI, Innovation, and What's NextConnect with Dr. Andrew SteeleWebsite: https://andrewsteele.co.uk/YouTube:    / drandrewsteele  Instagram:   / andrewjsteele  Twitter:   / statto  LinkedIn:   / andrewsteele  Bluesky: https://bsky.app/profile/statto.bsky....Mastodon: https://mas.to/@stattoThis video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/

In this in-depth conversation, Dr. Brad Stanfield sits down with Dr Matt Kaeberlein to discuss his journey from a primary care physician in New Zealand to a leading voice in the evidence-based longevity space. We cover the launch and philosophy behind his YouTube channel, the challenges and exciting results of his self-funded rapamycin clinical trial, and his critical perspective on supplements, medical guidelines, and the future of aging research.Dr. Stanfield provides a unique clinician's viewpoint on hot topics like GLP-1 agonists (Ozempic), SGLT2 inhibitors, vitamin D testing, and the pitfalls of biological age clocks. We also dive into a spirited debate on the role of medical societies, the balance between risk and benefit in prescribing medications, and why he believes the field of longevity is still in its early stages of discovery.Key Topics & Timestamps:00:00 - Introduction00:52 - Brad's Background02:47 - Starting the YouTube Channel & Philosophy on Science Communication07:39 - The Rigor of Clinical Data vs. Misinformation10:14 - Admitting Mistakes in Public (Resveratrol, Metformin)14:40 - Funding and Designing the Rapamycin Clinical Trial19:25 - Rapamycin Trial Results Submitted & Plans for a PhD23:28 - Preventative Care: New Zealand vs. US Healthcare Systems27:59 - The Vitamin D Debate: To Test or Not to Test?35:18 - Trust in Medical Guidelines & The Hormone Replacement Therapy Controversy43:42 - The Problem with Biological Age Clocks46:22 - Patient-Centered Care: Inform vs. Decide in Medicine49:49 - How to Judge the Quality of a Clinical Trial (CONSORT)53:44 - Risk vs. Benefit: When Should We Prescribe Preventative Drugs?58:05 - GLP-1 Agonists (Ozempic) and SGLT2 Inhibitors in Practice01:02:00 - Brad's Personal Use of an SGLT2 Inhibitor01:05:38 - The State of Longevity Research: How Much Do We Really Know?01:08:34 - Closing RemarksDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.Dr. Brad Stanfield's Socials:Website: https://drstanfield.com/YouTube: https://www.youtube.com/@DrBradStanfieldX: https://x.com/BradStanfieldMDMore places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://x.com/mkaeberlein Linkedin: https://www.linkedin.com/company/optispan/Instagram: https://www.instagram.com/optispan_/  TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Join me for an in-depth conversation with Dr. Alex and Dr. Jan from the YEARS Healthspan Clinic in Berlin. They pull back the curtain on what a truly evidence-based, scientific approach to longevity medicine looks like, moving beyond the hype and "snake oil" to focus on rigorous diagnostics, personalized interventions, and the critical collection of high-quality data.In this episode, they delve into the comprehensive 6+ hour diagnostic workup I am about to undergo, discuss the hierarchy of interventions (from lifestyle as the foundation to the careful use of pharmaceuticals), and debate the role of supplements, peptides, and more experimental therapies. This is a masterclass in the practical application of healthspan medicine from leading clinicians in the field.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Timestamps:00:00 – Trailer01:12 – Introduction02:19 – Inside the 6-Hour Health Assessment05:00 – Full-Body MRI & Advanced Testing11:57 – Biological Age Tests & Organ-Specific Clocks17:10 – "Scientific Healthspan" vs. Longevity Medicine25:50 – Reversing Type 2 Diabetes: A Real-World Case31:42 – Supplements: Separating Facts from Fads43:20 – Rapamycin, GLP-1s & Metformin: What's Proven?54:00 – Muscle Loss, Brain Health & Alzheimer's Prevention01:05:11 – Stem Cells, Exosomes & Peptides: Hype or Hope?01:12:57 – No Shortcuts: The Need for Clinical Trials01:17:47 – Preventive Cardiology & Lipid Management01:26:52 – Hormone Therapy: Men, Women & Misconceptions01:33:12 – The Longevity Field's Biggest Problem01:39:05 – "Dr. ChatGPT" & The Self-Diagnosis Dilemma01:43:14 – Why Healthcare Must Change Now01:45:26 – Closing ThoughtsDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel:    / @optispan  Get Our Newsletter (It's Free): https://www.optispan.life/Ever heard of a medical procedure that's been called an “oil change for your blood”?In this episode, I sit down with Dr. Brad Younggren to explore Therapeutic Plasma Exchange (TPE), a cutting-edge intervention that just might help extend healthspan, reduce biological age, and even clear hidden toxins like microplastics.We discuss the fascinating science behind TPE, from the famous parabiosis experiments in rodents to human trial data from Circulate and the Buck Institute. Dr. Younggren walks us through what really happens during TPE, which biomarkers shift the most, and who might benefit the most.This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:https://onebillionmedia.com/Chapters:00:00:00 — “Oil change for blood”00:01:05 — How TPE works (centrifuge)00:05:10 — Foundational science/parabiosis00:12:07 — Trial design & sham control00:22:39 — Headline result: “-2.6 years”00:34:01 — Compartment theory explained00:46:31 — Moving TPE to clinics00:48:03 — Long-COVID anecdote00:54:34 — Microplastics discussion01:06:38 — Cost & access overviewDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter:   / mkaeberlein  Linkedin:   / optispan  Instagram:   / optispan_  TikTok:   / optispan  https://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Longevity is a hot health topic, but what factors move the needle on not only how long you live but how long you experience relatively good health? Some lab and other tests can help assess how healthy you're aging and provide context for what lifestyle and other changes to make. Dr. Matt Kaeberlein and Mike Haney discuss the tests that help assess healthy aging, how mental health and physical health are intricately connected, which lifestyle factors might expand your health span, and where the research stands on various longevity topics.Get a Free Guide to Understanding Your Lab Results: https://levels.link/wnl

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Most people take supplements without ever checking if their body actually needs them. Is that smart… or just expensive guesswork?In this podcast, Dr. Matt Kaeberlein sits down with Ryan Ware to unpack the truth about supplements, the rise of AI in medicine, and how people are consuming health information today. From internet “gurus” to tools like ChatGPT, they explore where people are searching for health answers, and whether those answers are truly helping or quietly harming.Along the way, they share critical reflections on the wellness industry's blind spots, the limitations of blood tests, and what smarter, evidence-based health decisions really look like.Join the conversation to find out what really matters for your health, and what's just hype!This video was produced by One Billion Media, an agency that specializes in YouTube virality for health brands and experts. Learn more about their work here:*www.onebillionmedia.com**Chapters*00:00 – ChatGPT vs. social media for health advice07:15 – Bloodwork, Dexa scans & functional testing14:30 – Proactive vs. reactive medicine21:45 – The doctor's role in the AI era29:00 – Life-changing diagnostics: MRI, Dexa & CGM36:15 – Single biomarkers, noise & unreliable tests43:30 – Heavy metals, toxins & data challenges50:45 – HIPAA, biomedicine & broken data rules58:00 – AI bias, clinician oversight & misinformation01:05:15 – Pill mills, GLP-1s & hormone clinics01:12:30 – Scaling preventive care with AI01:19:45 – Why testing before symptoms mattersDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

One idea I've had lately is to put together a list of people to trust in geroscience and the longevity field more broadly. (And I might do it - keep an eye on reachlevity.com- and subscribe while you're at it!)Matt Kaeberlein would not only make that list - he'd likely be right at the top. He's rigorous, precise in his wording, and always puts integrity ahead of hype. But, and this is important, I wouldn't characterize him as a skeptic. He's a realist who insists on evidence, yet at the same time he's visionary and deeply optimistic about what aging science can deliver.Matt is probably best known for his pioneering work on rapamycin and for co-founding the Dog Aging Project. In this episode, though, we also talk about Optispan - his proactive healthcare company - and Ora Biomedical, where the WormBot platform is screening thousands of interventions for effects on lifespan. We get into therapeutic plasma exchange (TPE), how artificial intelligence might accelerate discovery, and even his favorite science fiction books.And true to form, Matt doesn't hold back. He calls out irresponsible use of biological age tests - going so far as to label it “medical malpractice” - and criticizes hype-driven actors, sloppy science communication, and the inertia of institutions like the NIH. At the same time, he shows how rigorous, honest work could move the entire field forward.-----

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Many people taking creatine get alarming results on standard kidney function tests, suggesting their kidneys are failing. This video explains why the popular supplement can create a false positive, debunks the myth of kidney damage, and reveals a more accurate blood marker you should know about.0:00 - The Creatine Dilemma1:00 - My Alarming Blood Test Results1:37 - Creatinine & EGFR: The Standard Test4:40 - The Better Marker: Cystatin C Explained6:32 - Proof: The Follow-Up Test7:35 - Who Else Is at Risk for a False Positive?8:42 - Conclusion: Should You Be Concerned?Production: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

In this episode, Dr. Matt Kaeberlein sits down with Joel Jamieson to explore the science of heart rate variability and how it connects to longevity, recovery, and performance. Joel shares his journey from training elite fighters to becoming a global authority on HRV training, emphasizing that healthspan is built on consistency, balance, and resilience rather than endless high-intensity workouts. The discussion dives into why VO2 max is one of the strongest predictors of longevity, how the parasympathetic nervous system and vagus nerve health regulate stress and recovery, and why zone 2 cardio, metabolic flexibility, and steady improvements in cardiovascular health matter more than chasing short-term results. This conversation reframes strength vs endurance, highlights key anti-aging biomarkers, and shows how recovery science can transform both athletes and everyday people seeking lasting health.

What if aging wasn't just something that happens to us, but something science could actually slow down? That's the question at the heart of today's conversation with Dr. Matt Kaeberlein, who's a leading scientist and longevity researcher at the University of Washington.Dr. Kaeberlein has spent decades decoding the biology of aging, from cellular mechanisms to practical strategies that could extend not just how long we live, but how well we live. In this episode, we talked about surprising connections between aging and brain health, and looked into the research around lithium and Alzheimer's to see what the latest science is telling us about extending healthspan.It is an informative discussion on whether aging itself can be slowed or reversed. If you're curious about how close we really are to changing the rules of aging, this could be worth a watch.Chapters00:00 – Introduction & The Biology of Aging Across Species10:57 – The Struggles of Change, GLP-1 Drugs & The Power of Sleep14:33 – The Hallmarks of Aging21:52 – Funding Issues23:22 – The Truth About Anti-Aging Drugs27:22 – Biological Age Testing 48:23 – Biomarkers, Advanced Testing & The Limits of Diagnostics01:02:50 – Micronutrient Testing and Supplements01:07:11 –  NAD, Smarter Longevity Choices01:18:05 –  Lithium's Secret Role in Aging and Memory Loss01:27:00 – Foundations of Longevity01:57:37 - Ovarian Aging02:01:02 – Closing Thoughts & Where to Find the Guest Guest's socials + websiteYouTube: https://www.youtube.com/@optispanX: https://x.com/mkaeberlein?lang=enWebsite: https://www.optispan.life/ Kayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

What if aging wasn't just something that happens to us, but something science could actually slow down? That's the question at the heart of today's conversation with Dr. Matt Kaeberlein, who's a leading scientist and longevity researcher at the University of Washington.Dr. Kaeberlein has spent decades decoding the biology of aging, from cellular mechanisms to practical strategies that could extend not just how long we live, but how well we live. In this episode, we talked about surprising connections between aging and brain health, and looked into the research around lithium and Alzheimer's to see what the latest science is telling us about extending healthspan.It is an informative discussion on whether aging itself can be slowed or reversed. If you're curious about how close we really are to changing the rules of aging, this could be worth a watch.Chapters:00:00 – Introduction & The Biology of Aging Across Species10:57 – The Struggles of Change, GLP-1 Drugs & The Power of Sleep14:33 – The Hallmarks of Aging21:52 – Funding Issues23:22 – The Truth About Anti-Aging Drugs27:22 – Biological Age Testing 48:23 – Biomarkers, Advanced Testing & The Limits of Diagnostics01:02:50 – Micronutrient Testing and Supplements01:07:11 –  NAD, Smarter Longevity Choices01:18:05 –  Lithium's Secret Role in Aging and Memory Loss01:27:00 – Foundations of Longevity01:57:37 - Ovarian Aging02:01:02 – Closing Thoughts & Where to Find the Guest Guest's socials + website:YouTube: https://www.youtube.com/@optispanX: https://x.com/mkaeberlein?lang=enWebsite: https://www.optispan.life/ Kayla's social + website:Instagram: https://www.instagram.com/kaylabarnes/TikTok: https://www.tiktok.com/@femalelongevityTwitter: https://x.com/femalelongevity Website: https://www.kaylabarnes.com/Follow Her Female Protocol: https://www.protocol.kaylabarnes.com/Become a Member of Kayla's Female Longevity Membership: https://kayla-barnes-lentz.circle.so/checkout/become-a-member

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/A new scientific paper reports that psilocybin, the compound in magic mushrooms, can extend lifespan in mice. A longevity scientist breaks down the data, exploring the study's strengths and weaknesses and discussing the potential biological mechanisms that could connect psychedelics to the aging process.0:00 - Why I'm Talking About Psilocybin3:08 - The Science of Psilocybin & Serotonin6:36 - Breaking Down The New Paper10:09 - The "Psilocybin Telomere Hypothesis"12:02 - The Cell Study: A Critical Look17:51 - The Lifespan Study in Mice (The Main Event)23:56 - How Could It Work? (Exploring the Mechanisms)30:55 - Final Thoughts & Future QuestionsProduction: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Today Dr. Kevin White and Erik Nelson join us for a deep-dive conversation as they unveil a new, multi-faceted program designed to halt and even reverse cognitive decline. They break down the key diagnostics, lifestyle pillars, and advanced therapies that form the foundation of their science-backed blueprint for brain health.0:00 - The Mission: Why We're Tackling Dementia16:14 - The Diagnostic Blueprint: Blood, Brain Scans & Cognitive Tests40:44 - The Foundation: Lifestyle as Brain Armor49:28 - Level 1: The Core Supplements for Brain Health56:59 - Level 2: Game-Changing Medications (Rapamycin & More)1:12:47 - Level 3: The Experimental Frontier (TPE, Sauna & Peptides)1:23:24 - The Program Unveiled: Who It's For & How It WorksProduction: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein systematically breaks down ten of the most persistent myths in the health and aging space. From the truth about biological age tests and resveratrol to the real role of genetics and supplements, this episode separates scientific fact from expensive fiction.0:00 - Intro: A New Series on Longevity Myths0:49 - Myth 1: Can You Actually "Measure" Biological Age?5:05 - Myth 2: Are Supplements a "Core" Longevity Strategy?6:29 - Myth 3 & 7: "I'm Too Old" & The Role of Your Genes8:16 - Myth 4 & 6: The FDA & The Truth About Research Funding10:49 - Myth 5: The Resveratrol Lie20:24 - Myth 8: The Caloric Restriction Misconception23:52 - Myth 9 & 10: The Reality of Rapamycin & PeptidesProduction: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Meet the founders (Ivan Morgunov, Anna Vakhrusheva) of Unlimited Bio, a biotech company developing gene therapies in special economic zones, operating outside of traditional FDA regulation. This episode explores their model, the science behind their therapies targeting the extracellular matrix, and the future of accessible anti-aging treatments.0:00 - The Mission: Fighting Overregulation in Longevity9:31 - The Science: Why the Extracellular Matrix is Key30:16 - The Offshore Model: How It Works & The Controversies54:04 - Their First Therapy: VEGF Gene Therapy Explained55:51 - The Quality Debate: GMP vs. A New Approach1:24:16 - The Future Pipeline: Follistatin, Klotho & Combination Therapies1:48:27 - The Vision: A New Regulatory System for the USProduction: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/In this Ask Me Anything episode, longevity scientist Dr. Matt Kaeberlein tackles viewer questions on controversial topics like testosterone therapy and the longevity drug rapamycin. He also offers his science-based perspective on diet strategies, supplements, and body composition, separating fact from fiction for those looking to optimize their health.0:00 - Intro: The ITP Water Bottle2:52 - My Testosterone Protocol (Dose, Injections & What I Avoid)10:05 - Testosterone for Women?12:32 - Rapamycin Q&A (Dose, Side Effects & Cycling)18:45 - The Problem with 50+ Supplements20:55 - DEXA Scans Explained (Bone vs. Body Comp)28:00 - Diet Myths Debunked (TRE & Processed Foods)37:50 - Outro: Guinness & Irish PubsProduction: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://x.com/Optispan_IncTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispan_/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Join longevity pioneers Dr. Aubrey de Grey, Dr. Brian Kennedy, and Dr. Matt Kaeberlein for a rare, unfiltered discussion on the future of aging. They debate the timeline for longevity escape velocity, the promise of new damage-repair therapies, and offer their candid thoughts on today's experimental treatments.0:00 - Intro1:50 - Longevity Escape Velocity: Are We Close?7:20 - The Big Debate: Damage Repair vs. Slowing Growth15:36 - Aubrey's Groundbreaking Combination Study in Mice21:17 - The Stacking Problem: Why Don't Combinations Always Work?33:42 - The Clinical Frontier: What's Real vs. "Sketchy"?47:03 - Gene Therapy & TPE: Would These Experts Do It?1:00:13 - The Future: What Are They Most Excited About?Production: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Following a breaking news story about hospitalizations at a longevity conference, scientist Dr. Matt Kaeberlein shares his firsthand experience from the event. He reveals the dangerous mix of legitimate science, unregulated therapies, and outright pseudoscience, offering critical advice on how to separate hope from hype.0:00 - A Tale of Three Conferences5:35 - The Longevity 'Religious Revival'10:09 - The Peptide Incident: What Happened?21:36 - Red Flags: How to Spot a Charlatan24:35 - Gene Therapy, TPE & More: Hope or Hype?36:25 - Reacting to the News Story1:02:32 - The Story You Won't Believe ('Feeling Your Energy')Production: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes hel

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein shares his personal and candid journey with testosterone therapy, from initial symptoms and hesitation to the mistakes he made starting out. This conversation breaks down the real-world benefits, side effects, and essential lab work, offering a science-based guide for men considering TRT.0:00 - Why I'm Sharing My Story2:05 - The First Signs & My Doctor's Dismissal6:22 - Trying to Fix It Myself (Lifestyle & Supplements)15:26 - The Decision: My Biggest Fears About TRT20:51 - My First Mistake: Oral vs. Injections27:05 - The Results: How It Changed My Health28:40 - Real Talk: The Benefits & Side Effects44:27 - Debunking TRT Myths (Aging & Lifespan)Production: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Send us a textMost people say they want to live longer. Fewer stop to ask: what does “longer” actually feel like?In this follow-up to last week's conversation, Dr. Matt Kaeberlein sits down again with Dr. Nicki Byrne and Dr. Kevin White — this time for an especially detailed, behind-the-scenes deep dive into the blood work and biomarkers that actually matter for health span.If you've ever wanted to understand labs like ApoB, LP(a), fasting insulin, ferritin, hormone panels, or genetic testing — and how to interpret them like a longevity doc — this one's for you. The team walks through what they measure, what it means, and how they guide real-world decisions using data most doctors never mention.Whether you're a patient, a clinician, or just tired of biohacking buzzwords, this episode is packed with nuance, context, and clarity — so you can finally make sense of what your labs are telling you (and what to do next).

Send us a textMost people say they want to live longer. Fewer stop to ask: what does “longer” actually feel like?In this episode, Dr. Kevin White joins Dr. Nicki Byrne and Dr. Matt Kaeberlein for a fast-moving, smart, and practical conversation about health span — and what it really takes to stay strong, clear, and independent as you age.The trio breaks down the four pillars of health (eat, move, sleep, connect) and how to apply them in real life. You'll hear stories from the clinic, data that matters, and the kind of takeaways you can actually use — whether you're a curious patient or a clinician trying to make sense of continuous glucose monitors, inflammatory markers, or why one of your patients still eats sardines.This is part one of a two-part conversation originally recorded for the OptiSpan Podcast, hosted by Dr. Kaeberlein. Stay tuned for part two, where they dig into blood work, hormones, LP(a), genetic testing, and the future of personalized longevity medicine.

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Physicist Jan Gruber presents a radical theory of aging, describing it as a gradual loss of resilience against random, stochastic events. This new model challenges how we think about biological clocks and could revolutionize the way we measure health and develop future longevity therapies.0:00 - The Physics of Aging: A New Model5:34 - How Damage, Genetics & Lifestyle Fit In13:59 - The 2 Factors That Define Your Lifespan20:10 - A Better Way to Measure Biological Age?25:18 - "Enslavement": How One System Failure Causes Collapse27:31 - What Epigenetic Clocks Actually Measure37:00 - The Problem with Current Animal Studies45:11 - What Makes a Longevity Clock Truly Useful?Production: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt sits down with Dr. Nicki Byrne and Dr. Kevin White to break down the four essential pillars for a long and healthy life: eat, move, sleep, and connect. They also reveal the specific blood tests that go beyond a standard checkup to help you build a personalized health strategy.0:00 - From ER to Longevity: Why We Switched8:01 - The Eat Pillar: Protein, Fiber & CGMs15:22 - The Move Pillar: VO2 Max & Consistency20:23 - The Sleep Pillar: Routines & Trackers27:11 - The Connect Pillar: Stress & Relationships33:56 - Blood Tests That Actually Matter1:15:28 - The Truth About Hormone Health (Men & Women)1:25:23 - Longevity Community PitfallsProduction: Tara Mei, Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Dr. Matt Kaeberlein is one of the world's most respected scientists in the field of aging biology. In this episode, we unpack the real science of longevity — from mTOR inhibition and rapamycin to calorie restriction, biomarkers of aging, and what most people get wrong about lifespan vs healthspan. We go beyond the hype to ask: What actually works? What's still theoretical? And where is the frontier of human aging research heading? Topics we cover: The biology of aging: mTOR, autophagy, senescence Rapamycin in humans: What we know and don't Why extending healthspan matters more than living longer Matt's views on supplements, diet, and biomarkers The most misunderstood concepts in anti-aging Referenced studies include: Dog Aging Project Interventions Testing Program Rapamycin human trial data *** I'm Louisa Nicola — clinical neuophysiologist — Alzheimer's prevention specialist — founder of Neuro Athletics. My mission is to translate cutting-edge neuroscience into actionable strategies for cognitive longevity, peak performance, and brain disease prevention. If you're committed to optimizing your brain — reducing Alzheimer's risk — and staying mentally sharp for life, you're in the right place. Stay sharp. Stay informed. Join thousands who subscribe to the Neuro Athletics Newsletter → https://bit.ly/3ewI5P0 Instagram: https://www.instagram.com/louisanicola_/ Twitter : https://twitter.com/louisanicola_ Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Matt Kaeberlein is a globally recognized expert on the biology of aging and recurring on The Neuro Experience. In this episode, Matt explains his research findings on nutrition as it relates to aging and longevity, including his opinions on the fastest growing "longevity" supplements on the market.Sponsors:BonCharge- Get 15% off any product when you visit https://boncharge.com/Momentous – Science-backed supplements trusted by elite athletes and experts. Whether you're looking to improve recovery, performance, or overall wellness, Momentous has you covered. Use code NEURO for 20% off your order: https://www.livemomentous.com/neuroThe Neuro Athletics Newsletter Instagram: @louisanicola_Twitter : @louisanicola_YouTube: @Louisa NicolaThe Neuro Experience Podcast is proud to have hosted: Dr Andrew Huberman, Dr Gabrielle Lyon, Dr Layne Norton, Thomas DeLauer, Shawn Stevenson, Dr. Rocio Salas-Whalen, Saad Alam, Uma Naidoo, Dr. Lanna Cheuck, Angela Lee Pucci, Jillian Turecki, Dr. Jordan Feigenbaum, Dr. Darren Candow, Dr. Sue Varma, Evy Poumpouras, Dr Casey Means, Renee Deehan, Dr Chris Palmer, Dr Charles Brenner, Dr Joe Zundell, Dr Ray Dorsy, Dr Dale Bredeson, Dr. Ben Bikman

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity expert Dr. Matt Kaeberlein breaks down three new scientific studies on the popular anti-aging drug rapamycin and the supplement taurine. Discover which research shows real promise for conditions like chronic fatigue and which studies are being overhyped in the longevity community.0:00 - Intro: 3 Hot Longevity Papers0:29 - Rapamycin for Alzheimer's: A Flawed Study?17:53 - A Breakthrough for Chronic Fatigue? (New Rapamycin Study)23:29 - The Promising Results: How Rapamycin Helped34:44 - Taurine: Does It Really Affect Aging?39:20 - The Big Miss: What the Taurine Study Didn't Do41:13 - Final Take: What This Science Actually Means for YouProduction: Tara Mei, Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt Kaeberlein tackles your burning questions on testosterone therapy, trending supplements like astaxanthin and C15, hyperbaric oxygen, and more. Get science-backed insights and learn what truly matters for starting your health and longevity journey.0:00 - Intro: Ask Matt Anything!0:42 - Testosterone Therapy: My Personal Journey3:12 - Hormone Health: What to Measure & Why It's Key8:24 - High APOB/LDL: Should You Worry?14:32 - Plasma Exchange vs. Donation: What's the Difference?18:55 - Hyperbaric Oxygen: Longevity Tool or Hype?26:18 - Astaxanthin & C15: "Miracle" Longevity Supplements?45:37 - Why Don't Scientists Give Straight Answers?Production: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt Kaeberlein reacts to controversial takes on supplements, MRIs, protein, and rapamycin from Dr. Eric Topol. This video breaks down the evidence behind popular health trends, helping you separate science from hype.0:00 - Setting the Stage: Expert Reaction1:03 - Experts Selling Supplements: Credibility Lost?2:30 - MRIs & CGMs: Lifesaving or Misleading?7:16 - Protein "Overdose": What's the Real Risk?11:11 - Rapamycin: Decoding the Data & Hype21:00 - The Hard Truth About Supplements (Matt's Take)39:36 - Biological Age: Can We Really Measure It?46:37 - CGMs: Powerful Tool or Just Trendy?Production: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Sean Gibbons, a leading microbiome expert, sits down with me to decode the complex world of your gut bacteria. Learn about good vs. bad bacteria, the impact of antibiotics and aging, and how diet and probiotics can influence your journey to better health.0:00 - Intro: What IS Your Microbiome?7:55 - Good vs. Bad Bacteria? The Real Story14:06 - Antibiotics & Your Gut's Rebound17:31 - Aging: Your Gut's Unique Journey26:36 - Diet: Can It Truly Change Your Gut?29:46 - Microbiome Tests: Useful or Just Hype?43:44 - Probiotics: Do They Actually Work?1:10:14 - Future of Gut Health (Bugs as Drugs, Smart Toilets)Production: Nicholas Arapis, https://videocastproductions.comDISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.More places to find us:Twitter: https://twitter.com/optispanpodcastTwitter: https://twitter.com/optispanTwitter: https://twitter.com/mkaeberleinLinkedin: https://www.linkedin.com/company/optispanInstagram: https://www.instagram.com/optispanpodcast/TikTok: https://www.tiktok.com/@optispanhttps://www.optispan.life/Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!

Send us a textIn this episode of The Daily Apple along with The OptiSpan Podcast, Matt Kaeberlein and Kevin reflect on their time at the Live Long Conference in Palm Beach—a vibrant gathering of scientists, clinicians, influencers, and longevity enthusiasts.They share their thoughts on powerful topics like therapeutic plasma exchange and hormone replacement therapy, while also exploring how diverse viewpoints can spark deeper understanding—and the openness to stay rooted in facts and open discussion. The conversation highlights the importance of critical thinking, respectful dialogue, and leaning on trusted voices in an age where health information comes from every direction.Whether you're new to the longevity conversation or deep in the research, this episode invites you to stay curious, open, and informed.TakeawaysThe conference featured a mix of speakers from various backgrounds.Diverse perspectives can lead to interesting discussions but also misinformation.Therapeutic plasma exchange shows promise for longevity but lacks extensive data.Hormone replacement therapy is a nuanced topic with differing opinions.Misinformation can harm public understanding of health issues.Experts should be cautious in presenting their opinions as facts.The audience needs open dialogue and guidance to navigate conflicting health information.Engaging discussions can arise from differing viewpoints.The importance of scientific rigor in health discussions cannot be overstated. Prime Health Associates

Send us a textIn this episode, Kevin and Dr. Matt Kaeberlein sit down to unpack one of the most cutting-edge tools in heart health today: the CLEERLY exam — a high-tech, AI-powered look at your arteries that doesn't just show your heart, it tells you what's really going on inside it.They walk through their own CLEERLY results (yep, you're getting the inside scoop), explain what plaque burden and stenosis actually mean, and why soft plaque is the sneaky troublemaker you need to know about.

What if aging isn't just inevitable—but modifiable? In this episode of Longevity Roadmap, Dr. Matt Kaeberlein breaks down the science of biological aging, with a focus on mTOR, epigenetics, and the hallmarks of aging like cellular senescence, mitochondrial dysfunction, and epigenetic drift. He explores the role of genetics vs. environment, the promise and pitfalls of metformin, NAD boosters, and senolytics, and why interventions like rapamycin and caloric restriction may extend health span. From the limitations of biological age tests to the importance of lean muscle mass, this conversation is a masterclass in evidence-based longevity research. Watch the full episode to understand the mechanisms of aging—and what current science says about slowing them down. Learn more about Dr. Matt Kaeberlein and Optisan: https://www.optispan.life/ - Download Dr. Buck Joffrey's FREE ebook, Living Longer for Busy People: https://ru01tne2.pages.infusionsoft.net/?affiliate=0 Book a FREE longevity coaching consultation with Dr. Buck Joffrey: https://coaching.longevityroadmap.com/

Send us a textImagine a healthcare experience where your doctor truly knows you, your concerns aren't rushed, and your wellness plan is as unique as you are. That's the heart of Concierge Medicine—a personalized, proactive approach that puts the focus back where it belongs: on you.In this episode taken from The Optispan Podcast with Dr. Matt Kaeberlein, we explore how deeper doctor-patient relationships, cutting-edge diagnostics, and tailored care are redefining what it means to stay healthy.What you'll learn:More time, more care – How longer, unrushed visits lead to better health outcomesBeyond the basics – The advanced tests and tools that provide a clearer picture of your well-being Surprisingly accessible – Why Concierge Medicine isn't just for the ultra-wealthy Designed for your lifestyle – From athletes to longevity seekers, how personalized care fits your needs 

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter In this special episode of The Drive, Peter introduces a brand-new roundtable format. Joined by three renowned experts in longevity science—Steven Austad, Richard Miller, and Matt Kaeberlein—the group explores the rapidly evolving field of geroscience. Together, they dive deep into topics like the relationship between healthspan and lifespan, evaluating interventions like rapamycin and senolytics, the role of epigenetic changes in aging, and whether GLP-1 receptor agonists hold geroprotective potential. They also tackle major challenges in funding and public acceptance of longevity research including how geroprotective interventions might be tested in humans. Packed with nuanced debate, humor, and groundbreaking insights, this episode is a must-listen for anyone fascinated by the science of aging. We discuss: The recent rise in public interest in longevity, misconceptions, and the link between healthspan and lifespan [3:45]; Redefining healthspan, the US healthcare paradox, and separating longevity science from commercial hype [12:30]; The need to redirect medical research from disease-specific models to aging-focused approaches [21:30]; Proactive healthcare: rethinking health, disease, and the role of aging [30:00]; Biologic age versus chronologic age, and the limitations and potential of epigenetic clocks [35:00]; The utility and drawbacks of the “hallmarks of aging” as a framework for research and funding [49:30]; The role of epigenetic changes in aging and the challenges of proving causality [56:45]; The translational challenges of moving aging research from preclinical studies to human applications [1:03:45]; Distinguishing between a biomarker of aging and aging rate indicators [1:17:15]; The difficulties of translating longevity research in mice to humans, and the difficulties of testing interventions in humans [1:21:15]; Exercise, aging, and healthspan: does exercise slow aging? [1:35:45]; Are GLP-1 receptor agonists geroprotective beyond caloric restriction effects? [1:41:00]; The role of senescent cells in aging, challenges with reproducibility in studies, and differing views on the value of current research approaches [1:46:15]; How funding challenges and leadership in NIH and other institutes impact the advancement of aging-related research [2:00:15]; Metformin: geroprotective potential, mechanisms, and unanswered questions [2:02:30]; Canagliflozin and rapamycin as geroprotective molecules: mechanisms, dosing strategies, and longevity potential [2:10:45]; Resveratrol and NAD precursors—a lack of evidence for anti-aging effects [2:22:45]; The potential of parabiosis and plasmapheresis to slow aging, the challenges in translating mouse studies to humans, and possible design for human studies [2:29:45]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube

Today's show is brought to you by MYOXCIENCE Nutrition. In this episode Matt Kaeberlein, PhD, CEO of Optispan, discusses the significance of enhancing health span through interventions like rapamycin and highlights the role of senescent cells in chronic inflammation and age-related diseases. Crush your workouts with the Creatine+ Electrolyte Combo by MYOXCIENCE: https://bit.ly/Electrolyte-Stix-Jar *Save with code podcast at checkout Link to show notes: https://bit.ly/4gdmxES Key Takeaways:  02:44 Pillars of health: eat, sleep, move, connect. 10:30 Eating protein and exercise can turn up mTOR. 15:20 High dietary protein and resistance training preserves muscle while aging. 19:20 Longevity research is underfunded. 25:10 Obesity was rare 50 years ago. 26:25 Fasting, and time restricting eating may not increase longevity. 30:45 Smoking, sedentary life, alcohol consumption and obesity shorten lifespan. 34:40 Resveratrol is not a longevity drug. 36:45 Spermidine is an autophagy booster. 38:10 Alpha ketoglutarate, urolithin A, and NAD precursors, may increase lifespan. 42:45 Acarbose, SGLT-2 inhibitors, and estrogens can increase lifespan. 44:45 Metformin does not corelate to reduced all-cause mortality. 47:30 NAD is a co-factor required for thousands of metabolic reactions. 52:55 Some epigenetic signatures are predictive of future health outcomes. 54:17 Facial imaging using AI can predict future health outcomes. 58:17 Dunedin Pace measures the rate of aging. 59:40 Optispan looks at epigenetics, blood glycan, and immune resilience/aging. 01:04:00 Senescent cells are cells that do not do their job and refuse to die. 01:07:50 Rapamycin impacts senescent cells, autoimmunity, and inflammation.