Podcasts about smc3

MyCarrier began a fight with project44 that they could never win. In a closely watched dispute over API services in the logistics industry, the Delaware Court of Chancery has found that MyCarrier likely did breach its contract with project44 both by "building behind" project44 as well as transitioning to an alternative provider, SMC3. Despite the likely breach, the Court determined that project44 failed to show irreparable harm, a key requirement for injunctive relief & denied project44's motion for a preliminary injunction against MyCarrier.

Our guest on this week's episode is John Lash, group vice president of product strategy at e2open. Good supply chains allow companies to remain competitive. But sometimes they need a bit of government help, especially when their competitors receive assistance from their own governments. That's one reason why the Biden Administration has launched the White House Council on Supply Chain Resilience. Our guest shares why this latest task force was created and what it is intended to address.Government regulations are always a big topic at trucking-industry events, and that was certainly the case this week at the SMC3 Connections conference in Colorado Springs. Connections is an annual educational event sponsored by SMC3. We share some of the highlights from the conference, including proposed government regulations that freight companies see as concerns due to their their implementation timelines.This week UPS sold its Coyote Logistics division to RXO. UPS had acquired Coyote for $1.8 billion in 2015, when it was a hot startup in the freight brokerage sector. Since that time, conditions have gotten really tough in the truckload freight business, which has been in a freight recession for about two years now. The sale reflects that downturn, as Coyote was sold for just over $1 billion. We look at the deal and discuss how both RXO and UPS will benefit from it moving forward.Supply Chain Xchange  also offers a podcast series called Supply Chain in the Fast Lane.  It is co-produced with the Council of Supply Chain Management Professionals.  Go to your favorite podcast platform to subscribe and to listen to past and future episodes.Articles and resources mentioned in this episode:e2openLegislation and the environment top trucking industry concernsUPS sells off Coyote brokerage arm to RXO for $1.025 billionGet episode transcriptsVisit Supply Chain XchangeListen to CSCMP and Supply Chain Xchange's Supply Chain in the Fast Lane podcastSend feedback about this podcast to podcast@agilebme.comPodcast is sponsored by: Equipment DepotOther linksAbout DC VELOCITYSubscribe to DC VELOCITYSign up for our FREE newslettersAdvertise with DC VELOCITYTop 10 Supply Chain Management Podcasts

Our guest on this week's episode is Melanie Nuce-Hilton, senior vice president, innovation and partnerships, at GS1 US. The world has long used barcodes for data tracking and transactions – we see them stamped on nearly every product we buy. However, new standards are being introduced to replace the humble bar code with more sophisticated codes that can contain much more data. We talk about the benefits and use cases for the newer 2D types of barcodes.We've been hearing about the potential for autonomous self-driving trucks for a few years now. The technology could be applied in transportation and could ease driver shortages. There have been a number of pilot programs for testing autonomous vehicles, but we also see some opposition to their adoption over concerns of safety. Today we share some of the latest news concerning these autonomous technologies. Speakers at this year's SMC3 JumpStart conference in Atlanta shared their views that the challenging conditions that have plagued freight markets for the past couple of years will continue in 2024 – but that the volatility will diminish as the year progresses. We share details on what they had to say.CSCMP's Supply Chain Xchange  also offers a podcast series called Supply Chain in the Fast Lane.  It is co-produced with the Council of Supply Chain Management Professionals.  Go to your favorite podcast platform to subscribe and to listen to past and future episodes.Articles and resources mentioned in this episode:GS1 USRyder and Kodiak open autonomous truck port in HoustonTeamsters and police opposed South Dakota bill allowing autonomous vehiclesSluggish outlook prevails, freight leaders sayGet episode transcriptsVisit Supply Chain XchangeListen to CSCMP and Supply Chain Quarterly's Supply Chain in the Fast Lane podcastSend feedback about this podcast to podcast@agilebme.comPodcast is sponsored by: ApteanOther linksAbout DC VELOCITYSubscribe to DC VELOCITYSign up for our FREE newslettersAdvertise with DC VELOCITYTop 10 Supply Chain Management Podcasts

Our guest on this week's episode is Bart De Muynck, chief industry officer at project44. The world continues to see the effects of climate change, and now it is affecting our transportation networks. Ongoing drought conditions in Central America have caused lower water levels in the Panama Canal, restricting the number of vessels and the amount of containers they can carry as they make the canal journey. How long will the restrictions possibly last and what will be the effects on ocean shipping as we approach peak season?  Our guest shares his insights. The slow period in trucking is expected to continue, according to industry experts gathered at the SMC3 Connections supply chain conference this week in Orlando. They expect the sluggish freight conditions will hang around for a while and that a broader economic recession is likely to follow.One of the biggest challenges for any company in logistics right now is labor. With low unemployment rates, skills shortages, boomer retirements, and having to compete with gig work jobs, it can be hard for many transportation and warehousing companies to stay fully staffed. This week we learned about another complication in that area, which is the rising rate of positive drug tests as more states legalize the private use of marijuana. That  trend makes it even harder to find good workers.DC Velocity's sister publication CSCMP's Supply Chain Quarterly  offers a podcast series called Supply Chain in the Fast Lane.  It is co-produced with the Council of Supply Chain Management Professionals.  A new eight-part series on Transportation Tech has launched. Go to your favorite podcast platform to subscribe and to listen to past and future episodes.Articles and resources mentioned in this episode:project44Slow times to continue, trucking industry experts sayPositive drug tests in US workforce rise to 20-year high as marijuana is legalizedGet episode transcripts.Visit Supply Chain QuarterlyListen to CSCMP and Supply Chain Quarterly's Supply Chain in the Fast Lane podcastListen to Supply Chain Quarterly's Top 10 Supply Chain Threats podcastSend feedback about this podcast to podcast@dcvelocity.comPodcast is sponsored by:Travero LogisticsOther linksAbout DC VELOCITYSubscribe to DC VELOCITYSign up for our FREE newslettersAdvertise with DC VELOCITYTop 10 Supply Chain Management Podcasts

Our guest on this week's episode is Dwight Klappich, research vice president and Gartner Fellow in Gartner's Logistics and Customer Fulfillment team. He shares new research that Gartner has conducted into how robotics will be used in distribution centers. Within the next few years, distributors will deploy a number of different categories of robots for various warehouse tasks. These systems will need a collaborative platform to work together. He shares details on how Gartner views the future of this crucial and expanding market.The SMC3 JumpStart conference was held in Atlanta this week and featured a number of speakers sharing their thoughts around a weaker freight environment, tech investments that should be made, and how companies should take stock of their operations and priorities during the current economic slowdown.New research into last-mile deliveries shows that the final mile has grown more complex, expensive, inefficient, and unsustainable. As a result, the majority of retailers have outsourced their delivery networks. This has lowered costs, but has reduced their control, making some rethink whether speed or reliability is more important to their customers.DC Velocity's sister publication CSCMP's Supply Chain Quarterly  offers a podcast series called Supply Chain in the Fast Lane.  It is co-produced with the Council of Supply Chain Management Professionals. The third season of eight episodes has fully launched  and focuses on attracting and retaining labor in our supply chains.  Go to your favorite podcast platform to subscribe.Articles and resources mentioned in this episode:GartnerEconomy and technology take center stage as SMC3 conferenceRetailers lose visibility as they outsource last mile delivery, FarEye saysVisit DCVelocity.com for the latest news. Visit Supply Chain QuarterlyListen to CSCMP and Supply Chain Quarterly's Supply Chain in the Fast Lane podcastListen to Supply Chain Quarterly's Top 10 Supply Chain Threats podcastSend feedback about this podcast to podcast@dcvelocity.com.Podcast is sponsored by:  BeckoffOther linksAbout DC VELOCITYSubscribe to DC VELOCITYSign up for our FREE newslettersAdvertise with DC VELOCITYTop 10 Supply Chain Management Podcasts

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.21.525018v1?rss=1 Authors: Gonzalez-Martin, E., Jimenez, J., A. Tallada, V. Abstract: Cohesin is a ring-shaped protein complex highly conserved in evolution that is composed in all eukaryotes of at least two SMC proteins (Structural Maintenance of Chromosomes) SMC1 and SMC3 in humans (Psm1 and Psm3 in fission yeast), and the kleisin RAD21 (Rad21 in fission yeast). Mutations in its components or its regulators cause genetic syndromes (known as cohesinopathies) and several types of cancer. It has been shown in a number of organisms that only a small fraction of each subunit is assembled into complexes. Therefore, the presence of an excess of soluble components hinders dynamic chromatin loading/unloading studies using fluorescent fusions in vivo. Here, we present a system based on bimolecular fluorescent complementation in the fission yeast Schizosaccharomyces pombe, named Bi-molecular Fluorescent Cohesin (BiFCo) that selectively excludes signal from individual proteins to allow monitoring the complex assembly/disassembly within a physiological context during a whole cell cycle in living cells. This system may be expanded and diversified in different genetic backgrounds and other eukaryotic models, including human cells. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Our guest on this week's episode is Christopher Tang, the UCLA distinguished professor and Edward W. Carter Chair in Business Administration and also the faculty director of UCLA's Center for Global Management. We have all seen product shortages this summer, including a well-publicized shortage of infant meal formula. Professor Tang discusses what is causing shortages, both from supply chain issues and domestic supply problems, and what steps companies can take to mitigate future risks to their product supplies. Attendees at this week's SMC3 Connections conference in San Diego discussed many issues facing transportation companies. Executives of less-than-truckload (LTL) companies pointed out that inflation and labor issues are their biggest concerns. We find out what they had to say and what remedies might work and which probably will not work. This week the U.S. Supreme Court decided not to hear a challenge to California's controversial AB5 law, which was approved in 2019 but has been stuck in appeals courts ever since. The law requires transportation and delivery companies (as well as Uber and Lyft) to treat drivers as employees instead of contract workers. This sets the stage for the law to now take effect. How will this affect trucking firms and will other states adopt similar legislation?DC Velocity's sister publication CSCMP's Supply Chain Quarterly  offers a podcast series called Supply Chain in the Fast Lane.  It is co-produced with the Council of Supply Chain Management Professionals. The second season has now launched and focuses on supply chain digitalization.  Go to your favorite podcast platform to subscribe.Articles and resources mentioned in this episode:UCLA Center for Global ManagementLogistics industry is skeptical of proposed gas tax holidayInflation and labor challenges top LTL business leaders concernsLabor groups cheer Supreme Court decisions to let AB5 standVisit DCVelocity.com for the latest news. Visit Supply Chain QuarterlyListen to Supply Chain Quarterly's Top 10 Supply Chain Threats podcastListen to CSCMP and Supply Chain Quarterly's Supply Chain in the Fast Lane podcastSend feedback about this podcast to podcast@dcvelocity.com.Podcast sponsored by: Honeywell IntelligratedOther linksAbout DC VELOCITYSubscribe to DC VELOCITYSign up for our FREE newslettersAdvertise with DC VELOCITYTop 10 Supply Chain Management Podcasts

In this podcast, LM Group News Editor Jeff Berman interviews Joe Tillman, manager of education programs for SMC3.

In this podcast, LM Group News Editor Jeff Berman interviews Joe Tillman, manager of education programs for SMC3.

LTL has a highly unique set of practices, pricing and operations that sets it apart from truckload companies.  Training people wanting to enter the LTL field is a major challenge, especially if they are coming in cold from the outside. On this week's Drilling Deep, host John Kingston sits down with Brian Thompson, the chief commercial officer of SMC3, to discuss how his company approaches the challenges of getting the next generation of LTL employees and managers ready to take on the market.Also on the podcast, Kingston reviews the diesel market that propelled by the Russian invasion of Ukraine has been doing things it has never done before.Electric fleets are the future. Are you ready? Discover why ChargePoint is the right partner to take your operation electric to reduce fueling costs, eliminate emissions and help you turn e-mobility into a competitive advantage. Visit chargepoint.solutions/freightwavesFollow Drilling Deep on Apple PodcastsFollow Drilling Deep on SpotifyMore FreightWaves Podcasts

LTL has a highly unique set of practices, pricing and operations that sets it apart from truckload companies.  Training people wanting to enter the LTL field is a major challenge, especially if they are coming in cold from the outside. On this week's Drilling Deep, host John Kingston sits down with Brian Thompson, the chief commercial officer of SMC3, to discuss how his company approaches the challenges of getting the next generation of LTL employees and managers ready to take on the market.Also on the podcast, Kingston reviews the diesel market that propelled by the Russian invasion of Ukraine has been doing things it has never done before.Follow Drilling Deep on Apple PodcastsFollow Drilling Deep on SpotifyMore FreightWaves Podcasts

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.03.282186v1?rss=1 Authors: Stilianoudakis, S., Dozmorov, M. G. Abstract: High-throughput chromosome conformation capture technology (Hi-C) revealed extensive DNA looping and folding into discrete 3D domains. These include Topologically Associating Domains (TADs) and chromatin loops, the 3D domains critical for cellular processes like gene regulation and cell differentiation. The relatively low resolution of Hi-C data (regions of several kilobases in size) prevents precise mapping of domain boundaries. However, the high resolution of genomic annotations associated with boundaries, such as CTCF and members of cohesin complex, suggests they can inform the precise location of domain boundaries. Several methods attempted to leverage genome annotation data for predicting domain boundaries; however, they overlooked key characteristics of the data, such as spatial associations between an annotation and a boundary, and a much smaller number of boundaries than the rest of the genome (class imbalance). We developed preciseTAD, an optimized random forest model to improve the location of domain boundaries. Trained on high-resolution genome annotation data and boundaries from low-resolution Hi-C data, the model predicts the location of boundaries at base-level resolution. We investigated several feature engineering and resampling techniques (random over- and undersampling, Synthetic Minority Over-sampling TEchnique (SMOTE)) to select the most optimal data characteristics and address class imbalance. Density-based clustering and scalable partitioning techniques were used to identify the precise location of boundary regions and summit points. We benchmarked our method against the Arrowhead domain caller and a novel chromatin loop prediction algorithm, Peakachu, on the two most annotated cell lines. We found that spatial relationship (distance in the linear genome) between boundaries and annotations has the most predictive power. Transcription factor binding sites outperformed other genome annotation types. Random under-sampling significantly improved model performance. Boundaries predicted by preciseTAD were more enriched for CTCF, RAD21, SMC3, and ZNF143 signal and more conserved across cell lines, highlighting their higher biological significance. The model pre-trained in one cell line performs well in predicting boundaries in another cell line using only genomic annotations, enabling the detection of domain boundaries in cells without Hi-C data. Our study implements the method and the pre-trained models for precise domain boundary prediction using genome annotation data. The precise identification of domain boundaries will improve our understanding of how genomic regulators are shaping the 3D structure of the genome. preciseTAD R package is available on https://dozmorovlab.github.io/preciseTAD/ and Bioconductor (submitted). Copy rights belong to original authors. Visit the link for more info

In this episode, guest Brian Thompson, the chief commercial officer at SMC³, discusses what the transportation markets may look like through the end of the year, and in particular how the Covid-19 pandemic has affected the LTL (less-than-truckload) segment.Capacity for both trucking and air freight remains very tight as we navigate the pandemic. How long will it be before we see more capacity entering the market for shippers?And CSCMP EDGE is going virtual this year. Diane Rand, managing editor of CSCMP's Supply Chain Quarterly, joins us to talk about this year's conference and how you can navigate your way in the virtual environment.Episode web page with transcriptArticles and resources mentioned in this episode:SMC³ websiteGlobalTranz says pop-up fleet solution addresses tight capacity in freight marketsGlobal air freight market sees tight capacity as travelers stay homeCSCMP EDGE conference and registration informationCSCMP websiteDC VELOCITY's Covid-19 coverageVisit DCVelocity.com for the latest news. Send feedback about this podcast to podcast@dcvelocity.com.Podcast sponsored by DCV-TVOther linksAbout DC VELOCITYSubscribe to DC VELOCITYSign up for our FREE newslettersAdvertise with DC VELOCITYTop 10 Supply Chain Management Podcasts

The LTL sector of the trucking sector is generally more stable than the truckload carriers it shares the road with. But that doesn't mean it has faced the pandemic without major upheaval.On this week's Drilling Deep podcast, host John Kingston speaks with Brian Thompson, the chief commercial officer of SMC3. His company sets the base rates for LTL shipments and he has a special insight into how the sector is faring. Its primary base of business from industry is getting squeezed but growing last-mile deliveries of all sorts of products is offsetting some of that financial pain. Thompson discusses it on this week's podcast.More FreightWaves podcastsApple PodcastsSpotify

The LTL sector of the trucking sector is generally more stable than the truckload carriers it shares the road with. But that doesn't mean it has faced the pandemic without major upheaval.On this week's Drilling Deep podcast, host John Kingston speaks with Brian Thompson, the chief commercial officer of SMC3. His company sets the base rates for LTL shipments and he has a special insight into how the sector is faring. Its primary base of business from industry is getting squeezed but growing last-mile deliveries of all sorts of products is offsetting some of that financial pain. Thompson discusses it on this week's podcast.More FreightWaves podcastsApple PodcastsSpotify

SMC3: https://smc3.comCampbell Commercial Real Estate: https://dcampbellcommercial.com

"Serving the Transportation Industry for Over 80 Years: Checking in with SCM3” Supply Chain Now, Episode 261 Broadcast Live from CSCMP Atlanta Roundtable Event in Atlanta, GA This episode features Kendra Miller. Kendra Miller, SMC3’s director of alliance partner development, has spent her entire career in logistics. She served at Roadway Express/YRC for 12 years, beginning her role at the company in terminal operations before moving to Roadway’s corporate office to oversee customer care operations and 31 field customer care centers. Her experience with 3PLs includes serving as the Southeast vice president of sales for Astra/CFX Holdings. In her role at SMC3, Miller helps the logistics technology company’s alliance partners with product integrations and upgrades to new rating and transit-time solutions. Learn more about SMC3 here: https://www.smc3.com/ Upcoming Events & Resources Mentioned in this Episode: Subscribe to Supply Chain Now: https://supplychainnowradio.com/subscribe/ Connect with Kendra on LinkedIn: https://www.linkedin.com/in/kendra-miller-12a1004/ Connect with Scott on LinkedIn: https://www.linkedin.com/in/scottwindonluton/ Connect with Greg on LinkedIn: https://www.linkedin.com/in/gswhite/ SCN Ranked #1 Supply Chain Podcast via FeedSpot: https://tinyurl.com/rud8y9m Webinar on AI & Inventory Management: https://tinyurl.com/u7gmr9v Reverse Logistics Association Conference & Expo: https://rla.org/event/80 SCNR to Broadcast Live at MODEX 2020: https://www.modexshow.com/ SCNR to Broadcast Live at AME Atlanta 2020 Lean Summit: https://www.ame.org/ame-atlanta-2020-lean-summit 2020 Atlanta Supply Chain Awards: https://www.atlantasupplychainawards.com/ SCNR on YouTube: https://tinyurl.com/scnr-youtube The Latest Issue of the Supply Chain Pulse: https://conta.cc/2tXz9gT Check Out News From Our Sponsors: The Effective Syndicate: https://www.theeffectivesyndicate.com/blog Spend Management Experts: https://spendmanagementexperts.com/ APICS Atlanta: https://apicsatlanta.org TalentStream: https://talentstreamstaffing.com/ Verusen: https://www.verusen.com/ Georgia Manufacturing Alliance: https://www.georgiamanufacturingalliance.com/ ProPurchaser.com: https://tinyurl.com/y6l2kh7g Supply Chain Real Estate: https://supplychainrealestate.com/ Vector Global Logistics: http://vectorgl.com/ This episode was hosted by Greg White and Scott Luton. For more information, please visit our dedicated show page at: www.supplychainnowradio.com/episode-261

SCNR broadcasts live from Jump Start 19, Hosted by SMC3. Learn more: www.SMC3.com Featured guests included- Brian Thompson serves as chief commercial officer of SMC³, where he oversees the sales, marketing and industry education departments. Before joining SMC³, Thompson worked at YRC Worldwide for 17 years, most recently serving as vice president of pricing and yield management. Joe Tillman is Chief Operating Office of LogisticsTrainingCenter.com. Joe has over 15 years’ experience in inventory management, transportation, and warehousing. Hosted by Will Haraway and Scott Luton

SCNR broadcasts live from Jump Start 19, Hosted by SMC3. Learn more: www.SMC3.com Featured guest Lance Healy is the Chief Innovation Officer of Banyan Technology, as well as one of its founders. Lance is responsible for strategic partnerships as well as directing the next innovations Banyan will introduce to the market. As Banyan’s initial user, Lance served in many roles during the organization’s formation and growth including sales to implementation and support. Lance brings more than 15 years of experience in doing hundreds of client implementations. Lance holds a bachelor’s degree from Ohio University. Learn more about Banyan Technology here: https://www.banyantechnology.com/ Hosted by Will Haraway and Scott Luton

SCNR broadcasts live from Jump Start 19, Hosted by SMC3. Learn more: www.SMC3.com Featured guest Bob Farrell serves as Executive Chairman at GlobalTranz. Bob has 30+ years of experience and a proven track record of building high-growth software and technology-driven companies. Prior to GlobalTranz, Bob served as president and CEO of Kewill, a global leader in multimodal transportation management software. Prior to Kewill, Bob served as president and CEO of EDGAR Online, a leading global provider of XBRL software, services and data that was acquired by RR Donnelley & Sons (NASDAQ: RRD) in August of 2012. His role at EDGAR Online was preceded by his time as Chairman and CEO of Metastorm, a leading provider of Business Process Management (BPM) enterprise software and solutions that was acquired by Open Text (NASDAQ: OTEX) in February of 2011. Farrell also served as President of Mercator Software, a provider of enterprise application integration solutions; COO at LeadingSide, a global provider of unstructured data solutions; and held executive management positions at Computer Horizons Corp., a provider of IT services and solutions. Additionally, Bob is currently a Senior Advisor at Providence Equity focusing on investments in technology-enabled service companies. He also currently serves on the board of Billtrust, the premier provider of payment cycle management solutions; and Kitchen Brains, a pioneer and global leader in the development and deployment of integrated, end-to-end, wireless M2M networking solutions and SaaS applications for the commercial kitchen/food service industry. Previously, he served on the Board of FolioDynamix, an award-winning SaaS provider of investment management programs and wealth management platform solutions to financial services organizations that was acquired by Actua (NASDAQ: ACTA) in November of 2014; and on the Board of I.D. Systems (NASDAQ: IDSY), a leading global provider of wireless solutions. Learn more about GlobalTranz at www.globaltranz.com Hosted by Chris Barnes, Ben Harris, and Scott Luton

SCNR broadcasts live from Jump Start 19, Hosted by SMC3. Learn more: www.SMC3.com Featured guest Dr. Manjeet Singh serves as Research Director for DHL Supply Chain. In this role, he’s currently working on a variety of projects including: the development of warehouse improvement plug-in software called I.D.E.A.; the development of a Freight Optimization Tool which minimizes the ship spend by optimal division of routes; and Manjeet is working with the Global IT team on development of ad-hoc warehousing improvement tools. Connect with Dr. Manjeet Singh on LinkedIn and learn more about DHL here: http://www.dhl.com/en.html Hosted by Will Haraway and Scott Luton

SCNR broadcasts live from Jump Start 19, Hosted by SMC3. Learn more: www.SMC3.com Featured guest Kevin Springer serves as vice president of sales at SMC³, where he is responsible for the development and support of all SMC³ end-user shipper, carrier and logistics relationships. As a member of the executive strategy team, Springer contributes to future product and company direction. Springer has direct carrier experience with Emory Worldwide, supply chain logistics experience with EGL/CEVA, and EDI, and supply chain visibility experience with Descartes Systems Group. With more than 20 years of experience in the transportation, logistics and supply chain industries, his knowledge of sales, operations and IT processes helps SMC³ customers leverage pricing technology to better manage their supply chains. Springer holds an MBA from Brenau University and a BBA in marketing from Georgia State University. Connect with Kevin Springer on LinkedIn and learn more about SMC³ here: http://www.smc3.com/ Featured guestJP Wiggins is Co-Founder and Vice President of Logistics for 3Gtms. In this role, JP manages channels and partnerships for 3Gtms. He was most recently at SAP where he was the solution principal focusing on SAP’s transportation, warehouse and event management offerings in North America and previously directed industry marketing for the company’s transportation and logistics business unit. Before SAP, he was senior vice president and general manager for Descartes Systems Group’s supply chain, transportation and logistics applications business, and also had been vice president of product management for the company. Previously, JP was co-founder and senior vice president of logistics for Global Logistics Technologies (G-Log); co-founder and vice president of product management at dx/dt; and vice president of logistics at Weseley Software. He holds degrees in transportation & logistics and marketing from The Ohio State University. Connect with JP Wiggins on LinkedIn and learn more about 3Gtms here: https://www.3gtms.com/ Hosted by Will Haraway and Scott Luton

SCNR broadcasts live from Jump Start 19, Hosted by SMC3. Learn more: www.SMC3.com Featured guest Michael D. Golden is partner at Arnall Golden Gregory LLP and is co-leader of the firm’s Closely Held and Family Business Practice. He is also a member of the Mergers and Acquisitions, Real Estate, and Logistics and Transportation Practices. Mr. Golden’s practice focuses on counseling clients, both publicly held and privately owned, in growing their businesses through mergers and acquisitions, strategic partnerships and joint ventures, and creative financing arrangements (including both equity and debt). Mr. Golden also represents companies in their employee matters such as negotiating executive employment agreements and non-competition agreements. Mr. Golden’s clients cover a variety of industries, including business services, manufacturing and distribution, logistics and transportation, healthcare, and real estate. Prior to joining AGG, Mr. Golden was a law clerk for Judge Ernest Tidwell, United States District Court for the Northern District of Georgia. Learn more about AGG here: https://www.agg.com/ Featured guestRob Adams serves as Managing Partner for JGS Resources, a leading firm that provides transaction advisory services for the logistics, waste management, and staffing industries. Hosted by Will Haraway and Scott Luton

John Martin, Director of Business Development at MercuryGate and Brian Thompson, Chief Commercial Officer at SMC3 discuss the following questions and more in this timely and informative episode: In your experience working with clients, what are the biggest gaps in supply chain visibility and why do those gaps still exist? When it comes to transportation ... Read moreClosing the Gaps in Supply Chain Visibility [Video] The post Closing the Gaps in Supply Chain Visibility [Video] appeared first on Talking Logistics with Adrian Gonzalez.

Structural Maintenance of Chromosomes (SMC) proteins are vital for a wide range of cellular processes including chromosome structure and dynamics, gene regulation, and DNA repair. Whereas prokaryotic genomes encode for only one SMC protein that exists as a homodimer, eukaryotes possess six different SMC proteins that form three distinct heterodimeric complexes, with the holocomplexes additionally containing several specific regulatory subunits. The prokaryotic SMC complex is required for chromosome condensation and segregation. In eukaryotes, this function is carried out by the condensin complex with SMC2 and SMC4 at its core. The complex containing SMC1 and SMC3, named cohesin, is responsible for sister chromatid cohesion during mitosis and meiosis. Cohesin is also employed in DNA double-strand break repair, whereas condensin participates in single-strand break repair. The as yet unnamed SMC5-SMC6 complex is involved in several DNA repair pathways as well as homologous recombination in meiosis. SMC proteins consist of N and C-terminal domains that fold back onto each other to create an ATPase “head” domain, connected to a central “hinge” domain via long antiparallel coiled-coils. The hinge domain mediates dimerisation of SMC proteins and binds DNA, but it is not clear to what purpose this activity serves. The aim of this work was therefore to characterise the structure and function of the SMC hinge domain in more detail. Specifically, the hinge domains of the Pyrococcus furiosus SMC protein and of mouse condensin were studied. Both their high-resolution crystal structures as well as low-resolution solution envelopes were determined, and their DNA-binding activity was analysed qualitatively and quantitatively. While the SMC hinge domain fold is largely conserved from prokaryotes to eukaryotes, functionally relevant structural differences can be observed. Most importantly, the surface charge has been almost reversed throughout evolution. The data obtained confirm that of all three eukaryotic SMC complexes, condensin is most closely related to prokaryotic SMC proteins. Both the P. furiosus and the mouse condensin hinge domain preferentially bind single-stranded DNA, but the mouse condensin hinge displays a much higher affinity than its prokaryotic counterpart, suggesting that this function has been enhanced during the course of evolution. The single-stranded DNA-binding activity might be important for the function of the condensin complex in single-strand break repair, but probably plays a different role in prokaryotes, possibly in the DNA-loading process of the prokaryotic SMC complex during replication.