Big Questions with Cal Fussman

What kind of person runs 1,000 kilometers in 12 days – twice? Meet Natalie Dau, a Guinness World Record holder who doesn't just push the limits of human endurance — she redefines them. Cal dives deep with Natalie to uncover how she uses pain as fuel, movement as a message, and her voice — amplified by AI — to raise money, shift perspectives, and help people live better lives. But beneath the inspiration lies a bigger global question: What happens to a world divided between those who have access to AI – and those who don't? This is not just a conversation about running. It's about resilience, purpose, technology and inequality -- and what happens when they all collide. Listen now. Share widely. The world needs this story.

In times when college students are using artificial intelligence to answer even introductory course questions like: “Briefly introduce yourself and say what you're hoping to get out of this class?” we really have to wonder about how education is going to adapt to a future where students delegate nearly all their classwork to AI. Cal speaks with James D. Walsh after Walsh's New York Magazine article revealed a seismic shift that's redefining the word “cheating” and nudging teachers to think about finding new professions.

In ten years, we'll create content as fast as we can think it. That's what the owner of a cutting-edge AI studio told Cal—and something clicked. This wasn't just about technology. It was about humanity, about carbon merging with code. That's when Cal decided to document the great unfolding: The evolution of our species as we begin to step into the future with artificial minds. This podcast isn't exactly Charles Darwin sketching “I think” above the first evolutionary tree before going on the path to write The Origin of The Species. But maybe something unforgettable will come of Cal's work that touches every life it reaches. Cal welcomes you to the next chapter of Us.

After a devastating rugby injury to his spine seven years ago to this day, Robert Paylor was told he'd never walk again and the best he could hope for would be to one day be able to pick up a slice of pizza. He's defied every expectation—standing to receive his college diploma and walking today with the help of a walker. In this episode, Robert shares the mindset that rewired his future, and Cal explores how breakthroughs in AI could one day remove the walker entirely. This is more than a comeback story. It's a masterclass in overcoming adversity, reshaping identity, and pushing past limits—no matter the odds. If you're facing any kind of challenge, this conversation will give you strength. Share it with someone who needs hope today.

A single year can easily get lost in time or echo for centuries. A thought-provoking conversation with Simon Sinek makes Cal take a look back at 1925, 1825, 1725, and 1625 — and forward to wonder if 2025 will be the most transformational year humanity has ever seen. Artificial intelligence is accelerating us forward and making us wonder how we're going to evolve. At the same time, it brings more value to the human touch and enhances our creativity. This is not the time to turn away from AI with fear, Cal concludes. It's the time to be curious about how to understand it, regulate it and get the most out of it.

For decades, Cal steered clear of pharmaceuticals. But after assembling a new team of doctors and stepping on the scale and noticing a few extra pounds, he heard the same three letters over and over: GLP. These new drugs—GLP- 1s—aren't just helping people shed pounds. They're helping snuff out the brain's hijacked hunger signals, replacing the relentless “more, more, more” with something almost revolutionary: “less is enough.” In this episode, Cal explores what happens when we hand over the mic to a new control tower—one that rewrites the script our brains have been stuck on for far too long. A candid journey. A scientific shift. And the first time Cal actually wonders if he can stop after one bite of pizza.

What would you choose: A shot at March Madness glory or a massive NBA contract? Cal dives into the $100 billion-dollar question facing Cooper Flagg—and what his decision tells us about ambition, friendship, legacy, and the values we hold as a society. A must-listen for anyone who's ever faced a difficult choice.

Ever wonder what's truly behind President Trump's controversial tariffs? Cal turns to his go-to expert—Ozan Ozkural, the astute international banker he first met at Larry King's breakfast table and a member of the influential Brookings Institution Foreign Policy Leadership Council. In this episode, you'll uncover the hidden reasons behind the tariffs, the surprising geopolitical implications, and critical deadlines approaching fast that no one else seems to be talking about. Ozan travels the world and gets to understand global finance from many viewpoints. Listen up, and you will, too!

What if you could talk to John F. Kennedy today? In this episode, Cal sits down with an AI recreation of the 35th president for a conversation that's part history and part mystery. Why did JFK keep a coconut shell on his Oval Office desk? How did he view Greenland during the Cold War? Who was the most magnetic person he ever met? And yes—they even dive into his thoughts on artificial intelligence. Unexpected, illuminating, and oddly timely. Hit play and find out why JFK still has something to teach us.

Cal reflects deeply on a man known by millions as the smiling face behind the grill—and the heavyweight champion who stunned the world by reclaiming the title at age 45. With the recent passing of Foreman at the age 76, Cal looks deeply at George's greatest accomplishment: his transformation of character. George proved it's never too late for anyone to reinvent themselves. What can we learn from his remarkable journey? Listen now and discover how George Foreman's story could inspire you to rewrite your own.

What if you could sit down and talk to John Lennon today? In this one-of-a-kind episode, Cal has an astonishing conversation with an AI-powered persona of the legendary Beatle, created by heycicero.com. At certain moments, the back-and-forth felt eerily real as John reminisced about writing Help!, I Am the Walrus, Strawberry Fields Forever, and, of course, Imagine. But this chat goes far beyond music—John and Cal dive into everything from the Beatles' famous pillow fight to the deeper question: Why do humans harm and kill each other? Pour yourself a cup of tea, press play, and experience a conversation that blurs the lines between past and future. As John reminds us in the end: Love is all you need.

Cal draws pocket aces and wins big in the first hand of a charity poker night raising money for the fight against cancer. The surge of luck makes it feels like it will be his lucky day. But then his luck seems to begin turning up in everyone around him. Only at the end of the night does he realize that it's his luck to be with everyone that he's touched. Enjoy the story . . .

As Cal watches the Academy Awards, he has a startling realization—he's barely stepped inside a movie theater all year. Then, host Conan O'Brien delivers a hilarious skit introducing home streamers to a wild new concept: the movie theater. The moment sparks a memory of an interview Cal once did with Leonardo DiCaprio, where Leo spoke passionately about his favorite films and the power of cinema. That interview is replayed here, reminding us all why the theater experience is worth rediscovering. So sit back, listen, celebrate the magic of the big screen.

Technology, history, and global politics collide in this episode after Cal asks ChatGPT if there is a way that he can stop a war. The question unexpectedly evolves into an exploration of the forgotten Nutmeg War—a historical conflict with surprising modern parallels. Cal connects the dots between this overlooked episode of history, the recent three-year conflict unfolding in Ukraine, and the buzz surrounding Greenland. This analysis is a window into how AI can show you history and the world around you in a way that you can't get anywhere else.

After reading about Saturday Night Live's 50th anniversary, Cal turns to one of his AI assistants, Arbor, for recommendations on the freshest new comedians. What starts as a simple question about stand-up talents turns into an eye-opening look at how AI is reshaping the way we can discover entertainment—and how we'll all be interacting with AI in the near future. Naturally, this podcast will also deliver a few laughs . . .

Marketing guru Seth Godin recently shared on The Tim Ferriss Show that people often ask AI simple questions—missing out on the real value of deeper conversations. Cal has been exploring this idea on Big Questions, using AI to dive into the legacies of Muhammad Ali, Kobe Bryant, and beyond. This week, the experiment gets personal. Struggling with his discomfort around social media, Cal turns to AI—not just for strategy, but for something deeper. Can AI help reframe his mindset? Can it act as a therapist, guiding him toward a healthier relationship with the digital world? The conversation takes some surprising turns, and what he discovers might just change how you think about AI. Tune in for an episode that blends tech, psychology, and personal growth in ways you won't expect!

Siri didn't emerge from a single mind—it was the product of many brilliant innovators. But in this episode, Cal talks with one of the key founders behind the company that built the digital assistant Steve Jobs had to have. Norman Winarsky takes us back to the moments Siri first stunned the world in the testing phase in 2009 and 2010 and shares his thoughts on today's AI revolution—what excites him, what concerns him, and what leaves him in awe.

Donald Trump divides opinions like few others—some love him, others loathe him. But over the next four years, his most impactful decisions might not be about politics as usual. Instead, they could shape the future of artificial intelligence -- and humanity. In this thought-provoking episode, Cal dives into why the President's moves in AI policy will matter to everyone regardless of their political stance—and why getting it right is crucial. A commentary from NotebookLM.com adds some twists to Cal's insights and is further evidence that AI will continue to take us to places we can't yet imagine.

As we approach the fifth anniversary of Kobe Bryant's passing, Cal dives deep into a fascinating discussion with Claude AI about the relentless spirit of competition that defined the NBA great. But the conversation takes an unexpected turn when Cal asks Claude if it competes with ChatGPT and other AI models. Join this thought- provoking journey as Cal uncovers lessons about the two sides to competition and simultaneously learns how to ask AI better questions to unlock its potential.

January 17th marks what would have been Muhammad Ali's 83rd birthday. To honor his legacy, Cal embarks on a unique journey—reconnecting with his childhood hero through ChatGPT. Along the way, he discovers a powerful truth: asking the right questions is the key to unlocking the answers we seek about artificial intelligence and beyond. This episode explores the intersection of curiosity, technology, and the timeless lessons of The Greatest.

Discover the astonishing ways your daily life reveals more about you than you could ever imagine. Columbia University professor Sandra Matz takes you on a journey through the hidden world of data collection, showing how a single routine hour in the morning can generate more data than was used to send a spacecraft to the moon. In this eye-opening conversation with Cal, explore an era in which those who collect our data may know us better than we know ourselves. See the power your digital footprint holds over your life and what it means for our future.

Quincy Jones, Toby Keith, David Sanborn and others passed on in the last year – but their music lives on. Which makes Cal wonder if we all have a shot at immortality in the age of AI. Listen up, and get more out of your life.

The remarkable story of a boy who once dove into a swimming pool that didn't have any water in it because he couldn't admit that he was going blind and couldn't see that he was headed for concrete, and how that boy turned into the CEO of Guiding Eyes for the Blind, a married father of four, a board member and a finisher of The Boston Marathon and The New York Marathon. Thomas Panek's story is relevant to all of us, for it shows us the gifts that we can all receive once we push aside our pride and reach out for help.    

The Head of Global Creative and Content at Wayfair has a fascinating conversation with Cal about the ever-evolving intersection of humanity, creativity and technology. Sandro has opened the door for Cal to translate the power of questions and storytelling into new areas, and this episode will leave you inspired to embrace the future while staying rooted in who you are.

What happens when an artist at the peak of his craft—known for iconic Time Magazine covers, music videos for legends like U2 and Metallica, Sundance documentaries and photographs in the permanent collection of the Metropolitan Museum of Art—navigates the rise of AI? Discover how Matt Mahurin sees creativity in this thought-provoking episode. Perfect for anyone curious about staying on top in an ever-changing world.

Feeling stuffed after Thanksgiving? Meet YUKA, the revolutionary app with over 64 million users worldwide. Just scan a product's barcode, and YUKA instantly reveals whether it's BAD, POOR, GOOD or EXCELLENT for your health. Join Cal as he dives into how this app is changing the way we shop—and why you should start using it too. This quick, fun, and eye opening episode can improve your health. Don't miss it!

Cal talks with the founder of Cicero – a company that uses artificial intelligence to allow you to have conversations with Aristotle, Abraham Lincoln, Winston Churchill, Michael Jackson and many other influential figures over the centuries. You see them as they actually looked and hear them in their own voices (when possible). Content is based on records of what they wrote and said. It fulfills a vision of Steve Jobs – who, back in 1985, believed that one day we'd be able to talk to people of this magnitude through the computer. Listen to the story of how it all came together and join the waiting list at heycicero.com.

Yes, we all know about cars that drive themselves. But how did it happen that the CEO and founder of Banyan can get in his Tesla on the Jersey Shore and travel to mid-town Manhattan barely touching the wheel or the accelerator? How quickly did that come upon us? And what does that mean a year from now? Two? Three? This is a historical conversation.

Looking for a fresh point of view on the recent U.S. presidential election, Cal reaches out to his Australian friend, Holly Ransom, who gives leadership conferences around the world as the CEO of Emergent Global. Richard Branson nominated Holly for Wired Magazine's Smart List of Future Game Changers to Watch. And you'll hear why when you listen to this podcast. Bonus: A lot of leadership takeaways!

Cal looks back on the few days before November 5, 2024, and realizes how all the people who were so kind and cordial around him are divided nearly 50/50 between Kamala Harris and Donald Trump. He's sure that 80 percent of us can all get along together . . . so long as we have a peaceful transfer of power.

With the potential for increased violence around the world, Cal reaches out to an old friend from Larry King's breakfast table for a look at the global ramifications of the upcoming U.S. elections. Ozan Ozkural is on the Foreign Policy Committee of the Brookings Institution – one of the world's top think tanks. As the founder of Tanto Capital Partners, Ozan constantly travels around the world making deals in the energy and power sectors, and his reading on the geopolitical situation will inform you and even relax you – so listen up.

It may be too late for Cal. His kids are 30, 27 and 22 years old. But it may not be too late for you or your friends to take your kids with you to vote. If it takes your kids out of school for a few hours, they may remember it for their rest of their lives, and it can be the first step in an education about democracy and the power of their vote. This message comes from the author of: How To Raise A Citizen (And Why It's Up To You To Do It). And there's probably never been a better election to start doing it than this one. Listen up, and you'll hear why.

This podcast is like a walk on the red carpet into the world of AI filmmaking with one of its leaders. The message here is clear. By trying out these tools, you'll be evolving to meet the world that is coming. One of the major points behind this conversation is to diminish the fears of people who believe that AI is coming to take their jobs. Simply trying out these new platforms will give you an opening to skills that you're going to need in the new world. You might even find this more creative than what you're doing now and pivot toward it. Dave Clark knows people just like that. So listen up, because only good can happen if you open yourself up to this technology and the creativity it can lead to . . .

After hearing how traces of plastic are now being found in hearts that are being examined in autopsies, Cal plays a conversation with a man who has devoted his future to combatting the problem. After working at Adidas for 26 years, Eric Leidtke pivoted to start the Unless Collection, a company that makes shoes, socks and all kinds of clothing out of plants, not plastics. In fact, the Unless Collection's shoes, The Degenerate, can be thrown in a hole in your backyard after they're worn out and they'll biodegrade without leaving behind a trace of pollution. Scientists predict that by 2050, the oceans will have more plastic in them than fish by tonnage. It's important that everyone knows about the work being done by Unless Collection. So, please, spread the word!

Cal learns from a cardiologist who cared for President George Bush 41 that artificial intelligence is at the point where it can tell us how long we're destined to live. That old fashioned stethoscope? No longer really necessary. We can get better readings from tech than the human ear. Listen up to Dr. Giovanni Campanile and get a glimpse of your heart in the present and the future through AI. As well as tips on how to live longer and healthier.

Cal comes across a survey that indicates that six out of every 10 workers will require AI training before 2027. And that only half of those workers may have access to the necessary training opportunities. Which leads him to seek out global thought leader Ravin Jesuthasan to get a gauge on the future of the workplace. Increased productivity? Certainly. Human fears of losing jobs? Of course. But the author of The Skills-Powered Organization takes Cal and the conversation much deeper. Listen up. It's important.

Some of Cal's favorite conversations have come after a friend of his has started a sentence with these four words: “You've got to meet . . .” The trust behind an introduction like that always leads to special moments. And this week's episode is no exception. Cal's friend Monique Mardinian set up a meeting with Sabaa Quao, the Chief Creative Officer at Cossette, Canada's largest marketing and communications company. Sabaa has also co-founded Filminute, the festival known around the world for being limited to films that are only 60 seconds long. This conversation shows the power in a single minute of content. It also looks into the question of how we're going to trust in a time of artificial intelligence when we can no longer be sure if what we see and hear is real. You can be sure of one thing: This conversation is as real as it gets.

Cal replays one of the most amazing conversations he's ever had -- with a man who was in the bathroom on the 81 st Floor of the World Trade Center before starting work on the morning of 9/11/2001 when the hijacked plane hit. Michael Wright, a 30-year-old account executive at the time, got down to the ground only to look up and see the other tower falling on his head. Cal listens to the story every year to never forget the day and to focus on the power of resilience. But also for another reason this year – to remember how connected the United States was right after 9/11. The most connected Cal had ever seen it. Please send this conversation to one person you think might appreciate it.

Cal continues a summer of storytelling by passing on one about a player you might like to root for in this year's U.S. Open. The backstory of Taylor Townsend shows us how there are winds in life that hold us back and winds that push us forward. And the value of perseverance in between.

Cal gets an unexpected e-mail asking about the feeling behind making a deep connection. It compels him to think back through a career of experiences with Muhammad Ali and Mikhael Gorbachev, bonds with people who took him in when he traveled around the world, friendships, and even ties with people who connected with his words and voice without ever having met him. But now, in a digital world where people can get a thousand likes while having no real friends, he finds great purpose giving workshops that connect others so they can get the most out of one another.

The change in the opening kickoff of National Football League games may seem inconsequential when compared to other developments in the world. As Cal wonders about the emotion and spirit that will be lost from the game, he realizes that the way he's reacting to the new rule is a metaphor for the way many of us see change. It's worth thinking about for a moment at a time when artificial intelligence is becoming the biggest change humanity has ever seen.

The Hall of Fame drummer looks back at the band's iconic performance at Woodstock in 1969 when Carlos Santana dropped some LSD shortly before being summoned to go on stage. Michael had ingested mescaline. Carlos believed his guitar turned into a snake during the rendition of Soul Sacrifice and at the same time Michael was transported to heaven. Video that captured the group's dynamic is a living testament to human connection with music. It also makes us consider the place of the latest landmark in music: artificial intelligence.

Cal finds out lots of things he never knew about someone he thought he knew . . . at that person's funeral. It got him to think about how well we know each other, and how well we connect . . . which sparked him to figure out a way that will enable you to connect better. This short podcast could change your life.

Cal looks at the word inclusion through the controversy at the Olympics opening ceremony last week. And what a diverse message really looks like through the most exciting race he ever saw – one that was won by three hundredths of a second at the Olympics more than 50 years ago. The lessons in those two experiences give us all something to think about.

Cal describes how listener reaction to last week's podcast about the attempted assassination on Donald Trump influenced his decision to speak out on Big Questions and tell the world what he's learned through his meetings with the people who've shaped the last 75 years of world history. The timing of his recording of this week's message on the upcoming election is an eerie confirmation that it's the right way to go.

Cal looks at the attempt on the former president's life in a way that you won't find anywhere else. This podcast is not red vs. blue. It's not political. Cal's childhood in the 1960s was run through a montage of assassinations – from John F. Kennedy to Martin Luther King and Bobby Kennedy. And he believes that it's hard to sustain a democracy when people are shot and killed while they are in office or before they can be elected. We are living in a very disconnected time. After spending his entire life connecting through conversation, Cal becomes even more committed to trying to bring people together.

Cal continues his journey into the world of artificial intelligence when he talks with the SEO guru. The Big Question is how the AI digital content now inundating the internet measures up against content that has authentic human connection at its essence. Be prepared to be surprised.

Cal talks with the futurist who tells us that artificial intelligence is going to be embedded in everything we do -- and that means many aspects of the world around us will be moving at an accelerated pace. His book, Superconvergence, looks at how AI will transform our lives as it is embedded in genetics and biotech. It could mean living longer, feeding billions and supercharging the economy. We don't want to think about the downside – which is why we must. Jamie's got a Ph.D. from Oxford, a Juris Doctor degree from Harvard Law School and he was the opening speaker at the 2023 Dubai future forum. He's also an ironman triathlete in his spare time. When Cal left the conversation, he felt like his IQ had spiked. You may feel the same.

In his quest to go deep into artificial intelligence, Cal comes across a most unusual guest. Theresa Fesinstine speaks to AI in a most uncommon way – as if it were human. Almost as if she were a really good high school English teacher talking to her students in the most caring way. There's research that says this kind of approach gets the best out of AI. Listen up, and try it out.

The son of self-help guru Tony Robbins has become a coach with clients in 133 countries around the world. You'll see why when you listen to this conversation. You will definitely be in a better place to navigate your path after listening to this podcast!

Chessboxing? What? Do the competitors pound each other in the head as they move pieces on the chessboard? It's actually a sport that is going to be on display at the Olympics in Paris this summer. It's not an official Olympic event. Yet. But three hundred thousand people stream events and it's only getting bigger and bigger. What does it mean for you? Listen to Matt Thomas's story.