The Next ReGeneration Podcast

In the latest episode of the Next ReGeneration podcast, hosts Anina and Elena welcome Filippo Graziani, Professor of Periodontology at the University of Pisa, Italy. Together, they take you on a journey into the connection between oral and overall health, exploring how a healthy mouth can influence the entire body.  Graziani discusses research showing that periodontal therapy can significantly support glycaemic control in diabetic patients. He also highlights findings of oral bacteria in atheromatous plaques, illustrating the potential connection between periodontitis and cardiovascular disease.  Periodontitis can furthermore trigger systemic inflammation, thereby aggravating diabetes and increasing heart disease risk. In fact, 57 systemic diseases have already been associated with periodontitis, says Graziani.  As such, periodontal therapy not only improves patients' quality of life — it may even support cognitive functions.  How far can periodontal treatment go in shaping general health outcomes? 

In the latest episode of the Next ReGeneration podcast, hosts Anina and Elena welcome Farah Asa'ad, an expert in epigenetics from the Sahlgrenska Academy at the University of Gothenburg, Sweden. Together they take you on a journey into epigenetics—the science of how lifestyle and external factors influence gene activity. From her award-winning research to the role of epigenetics in periodontitis and peri-implantitis, Asa'ad unpacks complex mechanisms in a way that's easy to understand.  She explains how bacteria can alter the epigenetic profile of key immune genes, potentially leading to chronic inflammation and tissue destruction. Additionally, she discusses how epigenetic therapies, such as targeted drugs, could one day help restore oral health at a molecular level. Could this be the future of personalised dentistry?

For the latest episode of the Next ReGeneration podcast hosts Anina and Elena welcome Nadja Nänni, a specialist in reconstructive dentistry from the University of Zurich in Switzerland. Together they explore the intricate relationship between periodontology and prosthodontics. Nänni shares her perspective on removable versus fixed prostheses for periodontitis patients, and her hopes for future advancements in diagnosis and treatment. From optimising implant positioning and treatment planning to weighing up the pros and cons of screw-retained versus cement-retained restorations, this discussion is packed with valuable clinical insights.

In the latest episode of the Next ReGeneration podcast, hosts Anina and Elena welcome Ian Needleman, Professor of Periodontology and Healthcare Research at UCL Eastman Dental Institute in London, UK. A passionate runner himself, Needleman has devoted substantial research to exploring the oral health of athletes and its impact on their performance and overall well-being.   Needleman shares fascinating insights from his assessments of athletes' oral health during the London 2012 Olympic Games. His studies consistently reveal that elite athletes frequently suffer from poor oral health, a phenomenon observed across both developing and developed nations. Although the exact mechanisms linking oral health to sports performance are not yet fully understood, inflammation seems to be a key factor. Needleman's research underscores that enhancing oral health can significantly boost athletic performance.

For the latest episode of the Next ReGeneration podcast in 2024 hosts Anina and Elena are joined by Leonardo Trombelli. He shares his unique perspective on how periodontal treatments and implant surgery have evolved throughout the years to become less invasive for patients. Trombelli looks back on the serendipity moment when he came up with the idea of the single flap approach, that can be used to properly access many periodontal defects. He elaborates on taking advantage of the periosteum in peri-implant regenerative procedures and shares insights on how he came up with the Sub-periosteal peri-implant augmented layer (SPAL) technique to finally highlight his most recent idea of the pedicle periosteal flap. The connective tissue of Trombelli's career as a researcher and clinicians is his lifelong mission on making surgical procedures less complex and more accessible to clinicians of various skill levels, while at the same time reducing the invasiveness of the interventions for the patients.

In the latest episode of the Next Regeneration podcast, hosts Anina and Elena talk to Magda Feres, a renowned periodontist and chair of the Department of Oral Medicine, Infection and Immunity at Harvard School of Dental Medicine. Feres shares how her early passion for periodontology shaped the foundation of her extraordinary career. She opens up about the challenges she faced and how she overcame them to become a global leader in the field. The conversation highlights her groundbreaking research in periodontal microbiology and regenerative therapy, which have transformed clinical practices, as well as the key milestones that have defined her journey. Throughout the interview, Feres also discusses her dedication to mentoring young researchers and her commitment to empowering women to advance in academia. Her innovative research, impactful teaching, and unwavering support for the next generation of scientists continue to inspire and shape the future of periodontology. Don't miss this insightful and uplifting conversation!

In the latest episode of the Next Regeneration podcast, hosts Anina and Elena talk to Nikos Donos, who shares his more than 20 years of experience using biologics for tissue regeneration and discusses the potential and limitations of different biologic agents. Much of his research has contributed to a better understanding of how different biological factors can enhance specific pathways in the healing cascade, and therefore the importance of using them in a biologically oriented way to maximise their efficacy. In this interview, Donos reflects on how patient selection will become increasingly important. In this respect, biologics that specifically enhance the resolution of inflammation may likely be beneficial in patients with diseases with inflammatory pathogenesis, such as diabetes. Tune in now to discover expert insights on leveraging biologics for optimal tissue regeneration.

In the latest episode of the Next Regeneration podcast, hosts Anina and Elena talk to Lorenzo Tavelli about his inspiring journey as a periodontist and clinical researcher. Tavelli began his career in Milan, Italy, and then pursued his academic path at the University of Michigan, eventually moving on to the Harvard School of Dental Medicine. Along the way, he has published a remarkable number of influential papers on periodontal regeneration and implant dentistry. In this interview, Tavelli talks about how he became interested in periodontology and the important role his mentors played in shaping his career. He also discusses his belief that the future of dentistry will be more personalised, incorporating new biomaterials, advanced tissue engineering techniques and artificial intelligence.

In the latest episode of the Next Regeneration podcast, hosts Anina and Elena talk to Nagihan Bostanci, the Head of Internationalization in Dentistry and Professor of Inflammation Research in Periodontology at the Karolinska Institute in Stockholm, Sweden. Together they discuss her research on salivary biomarkers.  Bostanci suggests that salivary markers could revolutionise patient care by profiling risk, monitoring over time, and providing prognostic insights.  While a single marker may not be sufficient for point-of-care diagnostic tests, she reveals how biomarker analysis could complement existing clinical and radiographic tools. Bostanci also discusses the future of microfluidic devices and the potential of wearable tech for patient monitoring.

In the latest episode of the Next Regeneration podcast, hosts Anina and Elena talk to Nikos Mattheos about his remarkable journey as a periodontist, researcher, and academic teacher. Starting his career in Athens, Greece, Mattheos made significant contributions at the University of Malmö, Bern, and Hong Kong, where he published groundbreaking research in implantology. He explains how his early interest in digital technologies led to his research projects. An advocate of prosthetically driven implant placement, Mattheos shares his insights on the vital link between periodontology and prosthodontics. He also offers tips for successful implant crown design and offers a glimpse of future trends in implantology.

In the latest episode of the Next Regeneration podcast, hosts Anina and Elena talk to Frank Schwarz about his groundbreaking work on peri-implant diseases. Schwarz shares his extensive experience in the treatment of peri-implantitis and emphasises the importance of prevention and personalised care programmes. He discusses the various risk factors for developing peri-implantitis and potential prevention strategies. Schwarz also reflects on the differing views of patients and clinicians on what constitutes successful treatment. Finally, he offers his vision for the future of peri-implant disease research. While he doubts the feasibility of developing implants that are completely resistant to peri-implantitis, he believes the future lies in careful patient selection and modulation of the host immune response.

The use of host modulators represents a true paradigm shift in the way we think about treating inflammatory diseases. In the current episode of the Next Regeneration Podcast, hosts Anina and Elena interview Hatice Hasturk about her pioneering work on specialized pro-resolving lipid mediators (SPMs) for treating periodontal diseases, along with her team. Their approach represents a significant shift in how we handle inflammation, aiming for active resolution rather than suppression. The results of her translational research are promising and suggest that these modulators may not only target local inflammation but also have systemic effects, potentially breaking the link between periodontitis and systemic diseases. It's serious progress in the fight against inflammatory disorders.

A few years back 3D printing in dentistry sounded like science fiction. Today 3D printing allows to offer individualized treatments to patients. For the current episode of the Next Regeneration podcast hosts Anina and Elena meet Florian Thieringer, who is pioneering 3D printing in dentistry.  As a clinician and researcher he provides first hand insights into the practical applications of 3D printing technology. He highlights materials that are suitable for 3D printing and explains the clinical scenarios, in which in they could be used. Not missing is the glimpse into the future of 3D printing in dentistry.

Dive into the world of statistics in dentistry with our two hosts Anina and Elena and their guest Cláudio Mendes Pannuti. He is Associate Professor in the Department of Periodontics at the University of São Paulo (Brazil) and in this podcast he talks about his passion for statistics.  Starting with his journey into statistics, he stresses the importance of accessibility of statistical knowledge to students. He strongly advocates the involvement of statisticians in clinical trials and explains why understanding the disparity between statistical significance and clinical relevance is key. On top of that he provides valuable insights into sample size calculation and how to improve the quality of research manuscripts. 

Join hosts Anina and Elena in the latest episode of the Next ReGeneration Podcast for an engaging conversation with Danae Apatzidou, Associate Professor at the Department of Preventive Dentistry, Periodontology and Implant Biology at the Aristotle University of Thessaloniki (Greece).    Apatzidou shares her expertise and passion for stem cell therapy in the field of oral regeneration. She explains the complex mechanisms of stem cells and how they are likely to induce the regeneration of missing tissue. While preclinical advances in tissue engineering are promising, there are still significant challenges at the clinical level, which Apatzidou discusses in more detail in this podcast. She concludes by presenting exciting future prospects in stem cell research.

Join hosts Anina and Elena on the Next ReGeneration Podcast for a coffee talk with Gustavo Avila Ortiz, the Editor-in-Chief of the International Journal of Periodontics & Restorative Dentistry. Discover the details of running a scientific journal as they discuss what happens from the moment an author hits the "submit" button to when their article is published. Avila Ortiz shares insights into his role as a gatekeeper and coordinator in an environment where timely management of submitted papers can be a challenging. He highlights the importance of peer review and discusses how anonymity plays a crucial role in this process. Additionally, get a sneak peek into the future of scientific journals, especially in the context of digitalisation.   Tune in for a fascinating discussion on the behind-the-scenes of the academic publishing world.

Join our hosts, Anina and Elena, on the Next ReGeneration Podcast to discuss digital implantology. For this podcast episode, they have invited Tali Chackartchi, a member of the Osteology Expert Council and owner of a private clinic in Tel-Aviv, Israel, dedicated to periodontology and implant dentistry. As a renowned clinician, researcher, and speaker, Chackartchi shares her extensive expertise regarding the benefits and the challenges associated with guided implant surgery. She also emphasises the irreplaceable importance of the human element and highlights the timeless adage: "Remember, a fool with a tool is still a fool!"

Join our hosts, Anina and Elena, on the Next ReGeneration Podcast for a discussion about how dental scientific societies contribute to advancing science and fostering professional connections. For this podcast episode they have invited the leaders of two very influential associations in dentistry: David Okano, president of the American Academy of Periodontology (AAP), and Darko Božić, president of the European Federation of Periodontology (EFP).  Okano and Božić shed light on the important role of scientific societies in sharing knowledge, providing a platform for professionals, and guiding newcomers in the field.

Join our hosts, Anina and Elena, on the Next ReGeneration Podcast as they discuss the fascinating topic of autologous platelet concentrates with Reinhard Gruber, Professor of Oral Biology at the University Clinic of Dentistry in Vienna. Together, they shed light on the development, rationale, key components and critical considerations associated with blood products. Throughout this episode, Gruber shares a deep dive into the history and the use of autologous platelet concentrates to reveal their multifaceted role in wound healing. He offers a fresh perspective on platelets and reaffirms that they go beyond their status as a mere source of growth factors.  Let Reinhard Gruber take you on an entertaining journey, making the intricate mechanisms of wound healing accessible and comprehensible.

In the latest episode of our Next ReGeneration Podcast, our hosts Anina and Elena, engage in a compelling discussion with David Herrera, Professor of Periodontology from the University Com-plutense of Madrid. Together, they shed light on the urgent issue of Antibiotic Resistance. In 2050, it is estimated that 10 million lives could be lost due to antimicrobial resistance. Dentists, responsible for 10% of global antibiotic prescriptions, play a significant role in this context. Unfortunately, overprescription without considering the future implications has become a concerning part of the problem, as Herrera explains in our latest episode. Herrera talks also about guidelines and scientific evidence on antibiotic use in dentistry, from prophylactic treatments to managing chronic and acute conditions, as well as the impact it has on the microbiome. Stay informed and be part of the solution to combat this growing concern, safeguarding antibiotics for a healthier future.

In the latest episode of our Next ReGeneration Podcast, our hosts Anina and Elena engage in an insightful discussion with Alberto Monje, a distinguished researcher and private practitioner from Spain. Together, they explore the limitless possibilities of building online and offline networks to expand clinical knowledge in the oral regeneration community.  According to Monje, these networks serve as transformative platforms, allowing young clinicians to connect with the scientific world and stay up-to-date with the latest advancements, regardless of their location. Discover how Monje's passion for sharing scientific knowledge empowers clinicians worldwide, particularly those in underserved areas with limited access to resources.

In the latest episode of our Next ReGeneration Podcast, our hosts Anina and Elena engage in an insightful discussion with the esteemed Massimo De Sanctis and Giovanni Zucchelli, Chairs of the Department of Periodontology at the prestigious Universities of Milan and Bologna in Italy, respectively. Together, they share their remarkable journeys as mentor and mentee, unveiling the secrets to their incredible success.  Zucchelli passionately emphasizes the pivotal role of selecting the right mentor, declaring it as the key to unlocking a truly successful career. Drawing from his own menteeship experience with De Sanctis, he unravels the essential factors that contribute to this flourishing partnership. Meanwhile, De Sanctis highlights the profound significance of fostering personal relationships and cultivating an atmosphere of mutual respect.  Discover the transformative power of human connection in nurturing growth and achievement and   listen to the new episode now.   

In the latest episode of our Next ReGeneration podcast, our hosts, Anina and Elena, discuss the topic "From stress to ease" with Christina Pastan, assistant clinical professor in the Department of Endodontics and Director of Mind-Body Wellness at Tufts University.  In this exciting episode, Pastan unveils a treasure trove of practical tips to help you integrate mind-body wellness into your daily practice. By following her expert advice, you can achieve a better work-life balance, improving patient outcomes and overall well-being. With Pastan's inspiring mantra of "We are human beings, not human doings", you'll be equipped to start each day in clinics with renewed energy and focus, ready to tackle any challenge that comes your way.

In the latest episode of our Next ReGeneration podcast, our hosts Anina and Elena discuss the importance of publishing your research with Saso Ivanovski, Professor of Periodontology at the School of Dentistry at the University of Queensland, Australia. Ivanovski shares invaluable insights on selecting suitable journals for your research, common mistakes to avoid when submitting a paper, and key factors essential to getting a paper accepted. He also dives into pressing issues such as open-access, predatory and peer-reviewed journals. Whether you're a seasoned researcher or just starting out, this episode is packed with practical tips and advice to help you make a meaningful contribution to the scientific community. So, be sure to tune in and give it a listen. 

In the latest episode of our Next ReGeneration podcast, our hosts Anina and Elena delve into the topic of evidence-based dentistry. They have invited Elena Figuero, Professor in Periodontology at the University Complutense of Madrid (Spain), who brings a wealth of knowledge and lots of passion to the subject. While some may view evidence-based dentistry as a dry and uninteresting topic, Figuero breaks down the definition into three distinct pillars and shows how each one can be integrated into daily clinical practice.

"The era of personalised dentistry: myth or reality?" is the title of the new episode of our Next ReGeneration podcast. Our hosts, Anina and Elena, have invited William Giannobile, Dean of the Harvard School of Dental Medicine. Giannobile gives examples of how customized medical care is already being implemented in regenerative dentistry. New technologies like bioimaging and patient risk stratification are just some of the tools and strategies that can be used today for a personalised treatment plan.

In this episode, Fabio Vignoletti, a private practitioner from Verona in northern Italy,  talks about his career in academia before settling into his private practice. Looking back on his professional career, he explains why one should dream big: focus on milestones rather than planning too far ahead. Balancing his current private practice with research and teaching is a process that has led him to a happy life as a passionate and modern dentist.

Our hosts, Anina and Elena, have invited Purnima Kumar, Professor of Dentistry and Chair of the Department of Periodontology and Oral Medicine at the University of Michigan, who has pursued an academic career to talk about choosing the right professional pathway.  

For this episode of our podcast, Anina and Elena have invited Martina Stefanini. They talk about what it takes to be successful, the need for female mentors, who truly understand the dilemma of balancing work and family, and what Stefanini thinks about women's networks.  

For this episode, Anina and Elena have invited Ausra Ramauskaite and Jae Kook Cha, two renowned young researchers and former Osteology Research Scholars. They talk about their scholarship experience in Frankfurt and Madrid and give valuable tips on how to become a scholar. In addition, they share personal insights into what it takes to follow one's path as a young researcher and realise one's hopes and dreams.

In this episode, Anina and Elena have invited George Kitsaras. They discuss with him the possibilities of a dentist to achieve behavioural changes in a patient. Starting with an explanation of psychological models, he then shows how these have been translated into practical guidelines for dentists in their daily work with patients.

Anina and Elena have invited Daniel Thoma from the University of Zurich for the third episode of our podcast. They talk to him about the highly controversial topic of preclinical research, how it has changed over time, where there is still value in conducting preclinical research, and where it has been replaced. Furthermore, they also discuss regulations, limitations, and why transferring the results to humans is difficult. 

In this episode, Anina and Elena talked to Franck Renouard, who has published and lectured extensively on “human factors”. He explains how he became aware of this topic and its relevance in dental practice. His theory: most complications happen not because of the lack of knowledge but because of human behaviour and the wrong application of knowledge.

In the first episode they talked to Gustavo Giordani, who has more than 133'000 followers on Instagram. He explained why he finds it difficult to be called an “Influencer”, how he came to that big number of followers, and also where to be careful when dealing with information on social media.