Podcasts about okano

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Best podcasts about okano

Latest podcast episodes about okano

The Tubi Tuesdays Podcast
The Tubi Tuesdays Podcast Episode 159 - The Golden Bat aka Golden Ninja (1966)

The Tubi Tuesdays Podcast

Play Episode Listen Later Aug 26, 2024 88:56


Welcome to our podcast series from The Super Network and Pop4D called Tubi Tuesdays Podcast! This podcast series is focused on discovering and doing commentaries/watch a longs for films found on the free streaming service Tubi, at TubiTV Your hosts for Tubi Tuesdays are Super Marcey, ‘The Terrible Australian' Bede Jermyn, Prof. Batch (From Pop4D & Web Tales: A Spider-Man Podcast) and Kollin (From Trash Panda Podcast), will take turns each week picking a film to watch and most of them will be ones we haven't seen before.Movie Starts Playing At: 00:09:59Welcome back to The Tubi Tuesdays Podcast, the number one Tubi related podcast that's hosted by two Australians, one Canadian and one American! All four hosts are indeed here (for the most part) with Super Marcey, Bede Jermyn, Prof. Batch and Kollin! This week is Bede's pick, however his choice of film isn't a terrible one and it's one that Marcey also really enjoys with The Golden Bat aka Golden Ninja (1966)! For some reason the film goes by the title Golden Ninja on Tubi, but it is best known as The Golden Bat or Ôgon batto. The character of The Golden Bat may actually be the first comicbook superhero predating Superman, he may actually be the most fashion hero as well. Enjoy the show!The Golden Bat aka Golden Ninja was directed by Hajime Satô, it stars Sonny Chiba, Andrew Hughes, Wataru Yamagawa, Hisako Tsukuba, Emily Takami, Kôji Sekiyama and Kôsaku Okano.If you have never listened to a commentary before and want to watch the film along with the podcast, here is how it works. You simply need to grab a copy of the film or load it up on Tubi (you may need alcohol), and sync up the podcast audio with the film. We will tell you when to press and you follow along, it is that easy! Because we have watched the films on Tubi, it is a free service and there are ads, however we will give a warning when it comes up, so you can pause the film and provide time stamps to keep in sync.Highlights Include:* Phew Marcey is back!* Kollin's up and down due to the kids!* Gotta love that The Golden Bat dresses like Skeletor and Liberace!* Is there more unofficial product placement this episode?* Did you acknowledge your Tribal Kief today?* Look we really couldn't tell ya what's happening in this film!* The film is on the cheap side but quite a lot of fun!* Plus much, much more!Check out The Super Network on Patreon to gain early access to The Tubi Tuesdays Podcast!DISCLAIMER: This audio commentary isn't meant to be taken seriously, it is just a humourous look at a film. It is for entertainment purposes, we do not wish to offend anyone who worked on and in the film, we have respect for you all. Hosted on Acast. See acast.com/privacy for more information.

Do Your Good
#156 Supporting the Places that Rejuvenate You with Dana Okano, Program Director for Hawai‘i Community Foundation

Do Your Good

Play Episode Listen Later Nov 27, 2023 29:02


Dana Okano from Hawai'i Community Foundation joins us today to talk about the needs of her home state Hawai'i, and the importance of giving back to the land that rejuvenates you. She dives into the ongoing challenge of supporting environmental and community needs. Dana and Sybil dig deeply into her freshwater initiative and many of the important priorities in Hawai'i in order to donate and support local organizations in a place that many people visit for rejuvenation.Episode Highlights:Tips and strategies for effective giving Leveraging local resources in a place that rejuvenates youFavorite grants and initiativesDana Okano Bio:Dana Okano, PhD, AICP, (she/her) is Director of the Natural Environment sector at Hawai‘i Community Foundation, and is responsible for programs such as the Hawai‘i Fresh Water Initiative, Holomua Marine Initiative, and co-chairs the Hawai‘i Environmental Funders Group. She is also Director of the EPA-funded Hawaiian Islands Environmental Finance Center, providing Technical Assistance to communities across Hawai‘i for their water needs.Prior to joining the Foundation, Dr. Okano worked for the National Oceanic and Atmospheric Administration (NOAA) Coral Reef Conservation Program and Coastal Zone Management Program in Saipan, CNMI. Dr. Okano also previously worked as a Planner at County of Hawai‘i Planning Department, and she began her career as a Peace Corps Volunteer serving in Benin, West Africa. Links:Holomua Marine Initiative: https://dlnr.hawaii.gov/holomua/ Hawai'i Makai Watch: http://pupukeawaimea.org/programs/makai-watch Hawai‘i Community Foundation https://www.hawaiicommunityfoundation.org If you enjoyed this episode, listen to these as well:https://www.doyourgood.com/blog/150-pooled-funds-that-protects-sharkshttps://www.doyourgood.com/blog/129-jim-enotehttps://www.doyourgood.com/blog/leveraging-public-dollarsCrack the Code: Sybil's Successful Guide to PhilanthropyBecome even better at what you do as Sybil teaches you the strategies and tools you'll need to avoid mistakes and make a career out of philanthropy.Sybil offers resources including free mini-course videos, templates, checklists, and words of advice summarized in easy to review pdfs. Check out Sybil's website with all the latest opportunities to learn from Sybil at https://www.doyourgood.com Connect with Do Your Goodhttps://www.facebook.com/doyourgoodhttps://www.instagram.com/doyourgoodWould you like to talk with Sybil directly?Send in your inquiries through her website https://www.doyourgood.com/ or you can email her directly at sybil@doyourgood.com

Do Your Good
Dana Okano: Preview

Do Your Good

Play Episode Listen Later Nov 24, 2023 3:10


Dana Okano from Hawai'i Community Foundation joins us today to talk about the needs of her home state Hawai'i, and the importance of giving back to the land that rejuvenates you. She dives into the ongoing challenge of supporting environmental and community needs. Dana and Sybil dig deeply into her freshwater initiative and many of the important priorities in Hawai'i in order to donate and support local organizations in a place that many people visit for rejuvenation. {You can hear the full episode on Monday, November 27th}

The Next ReGeneration Podcast
The role of dental scientific societies - in science advancement and professional networking with David Okano and Darko Božić

The Next ReGeneration Podcast

Play Episode Listen Later Sep 27, 2023 39:10


Join our hosts, Anina and Elena, on the Next ReGeneration Podcast for a discussion about how dental scientific societies contribute to advancing science and fostering professional connections. For this podcast episode they have invited the leaders of two very influential associations in dentistry: David Okano, president of the American Academy of Periodontology (AAP), and Darko Božić, president of the European Federation of Periodontology (EFP).  Okano and Božić shed light on the important role of scientific societies in sharing knowledge, providing a platform for professionals, and guiding newcomers in the field.

PaperPlayer biorxiv neuroscience
Shared GABA transmission pathology in dopamine agonist- and antagonist-induced dyskinesia

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Jul 28, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.26.550763v1?rss=1 Authors: Abe, Y., Yagishita, S., Sano, H., Sugiura, Y., Dantsuji, M., Suzuki, T., Mochizuki, A., Yoshimaru, D., Hata, J., Matsumoto, M., Taira, S., Takeuchi, H., Okano, H., Ohno, N., Suematsu, M., Inoue, T., Nambu, A., Watanabe, M., Tanaka, K. F. F. Abstract: Dyskinesia is involuntary movement caused by long-term medication with dopamine-related agents: the dopamine agonist, L-DOPA, to treat Parkinson disease (L-DOPA-induced dyskinesia [LID]) or dopamine antagonists to treat schizophrenia (tardive dyskinesia [TD]). However, it remains unknown why distinct types of medications for distinct neuropsychiatric disorders induce similar involuntary movements. Here, we searched for a shared structural footprint using magnetic resonance imaging-based macroscopic screening and super-resolution microscopy-based microscopic identification. We identified the enlarged axon terminals of striatal medium spiny neurons in both LID and TD model mice. The striatal overexpression of vesicular gamma-aminobutyric acid transporter (VGAT) was necessary and sufficient for modeling these structural changes; VGAT levels gated the functional and behavioral alterations in dyskinesia models. Our findings indicate that lowered type 2 dopamine receptor signaling with repetitive dopamine fluctuations is a common cause of VGAT overexpression and late-onset dyskinesia formation, and that reducing dopamine fluctuation rescues dyskinesia pathology via VGAT downregulation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PaperPlayer biorxiv neuroscience
An efficient induction method for human spinal lower motor neurons and high-throughput image analysis at the single cell level

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Apr 19, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.04.18.537412v1?rss=1 Authors: Setsu, S., Morimoto, S., Nakamura, S., Ozawa, F., Tomari, Y., Okano, H. Abstract: This study presents a newly developed method to rapidly and efficiently induce human spinal lower motor neurons (LMNs) from induced pluripotent stem cells (iPSCs) for elucidation of the amyotrophic lateral sclerosis (ALS) pathomechanism and drug screening. Previous methods had several limitations such as poor efficiency and low purity of LMN induction and labor intensiveness of the induction and evaluation procedures. Our new protocol achieved nearly 80% induction efficiency in only 2 weeks by combining a small molecule-based approach and transduction of transcription factors. To overcome cellular heterogeneity, we analyzed morphology and viability of iPSC-derived LMNs on a cell-by-cell basis using time-lapse microscopy and machine learning, thus establishing a highly accurate pathophysiological evaluation system. Our rapid, efficient, and simplified protocol and single cell-based evaluation method allow the conduct of large-scale analysis and drug screening using iPSC-derived motor neurons. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PaperPlayer biorxiv neuroscience
Modeling the marmoset brain using embryonic stem cell-derived cerebral assembloids

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Mar 1, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.28.530008v1?rss=1 Authors: Kodera, T., Takeuchi, R. F., Takahashi, S., Suzuki, K., Kassai, H., Aiba, A., Shiozawa, S., Okano, H., Osakada, F. Abstract: Studying the non-human primate (NHP) brain is required for the translation of rodent research to humans, but remains a challenge for molecular, cellular, and circuit-level analyses in the NHP brain due to the lack of NHP brain system. Here, we report an NHP cerebral model using marmoset (Callithrix jacchus) embryonic stem cell-derived cerebral assembloids (CAs) that recapitulate inhibitory neuron migration and cortical network activity. Cortical organoids (COs) and ganglionic eminence organoids (GEOs) were induced from cjESCs and fused to generate CAs. GEO cells expressing the inhibitory neuron marker LHX6 migrated toward the cortical side of CAs. COs developed their neural activity from a synchronized pattern to an unsynchronized pattern as COs matured. CAs showed mature neural activity with an unsynchronized pattern. The marmoset assembloid system will provide an platform for the NHP neurobiology and facilitate translation into humans in neuroscience research, regenerative medicine, and drug discovery. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

PaperPlayer biorxiv neuroscience
Highly efficient induction of functionally mature excitatory neurons from feeder-free human ES/iPS cells

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Feb 12, 2023


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.02.10.528087v1?rss=1 Authors: Zhou, Z., Kakegawa, W., Fujimori, K., Sho, M., Shimamura, R., Supakul, S., Yoshimatsu, S., Kohyama, J., Yuzaki, M., Okano, H. Abstract: Cortical excitatory neurons (Cx neurons) are the most dominant neuronal cell type in the cerebral cortex and play a central role in cognition, perception, intellectual behavior, and emotional processing. Robust in vitro induction of Cx neurons may facilitate as a tool for the elucidation of brain development and the pathomechanism of the intractable neurodevelopmental and neurodegenerative disorders, including Alzheimers disease, and thus potentially contribute to drug development. Here, we report a defined method for the efficient induction of Cx neurons from the feeder-free-conditioned human embryonic stem cells (ES cells) and induced pluripotent stem cells (iPS cells). Using this method, human ES/iPS cells could be differentiated into ~99% MAP2-positive neurons by three weeks, and these induced neurons displayed several characteristics of mature excitatory neurons within 5 weeks, such as strong expression of glutamatergic neuron-specific markers (subunits of AMPA and NDMA receptors and CAMKII), highly synchronized spontaneous firing and excitatory postsynaptic current (EPSC). In addition, the Cx neurons showed susceptibility to A{beta} oligomer toxicity and excessive glutamate excitotoxicity, which is another advantage for toxicity testing and searching for therapeutic agent discovery. Taken together, this study provides a novel research platform for studying neural development and degeneration based on the feeder-free human ES/iPS cell system. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

BE Podcast
Kieta Hatsukoi Recap Ep 8: Very Awkward

BE Podcast

Play Episode Listen Later Oct 24, 2022 59:55


In this episode Billy and Emma recap episode 8 of Kieta Hatsukoi.  Billy and Emma share their different opinions on Mr. Okano and how he acted through the episode.  And they discuss the (very slow) progression of Aoki and Ida's relationship.  They also play an audio message that was sent in by one of their listeners.  --- Send in a voice message: https://podcasters.spotify.com/pod/show/be-podcast6/message

PaperPlayer biorxiv neuroscience
Multi-modal brain magnetic resonance imaging database covering marmosets with a wide age range

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Sep 22, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.09.21.508952v1?rss=1 Authors: Hata, J., Nakae, K., Tsukada, H., Woodward, A., Haga, Y., Iida, M., Uematsu, A., Seki, F., Ichinohe, N., Gong, R., Kaneko, T., Yoshimaru, D., Watakabe, A., Abe, H., Tani, T., skibbe, h., Maeda, M., Papazian, F., Hagiya, K., Kishi, N., Shimogori, T., Yamamori, T., Okano, H. j., Okano, H. Abstract: Magnetic resonance imaging (MRI) is a noninvasive neuroimaging method beneficial for the identification of normal developmental and aging processes and data sharing. Marmosets have a relatively shorter life expectancy (approximately 10 years) than other primates, including, humans because they grow and age faster. Hence, the common marmoset model is effective in aging research. The current study investigated the aging process of the marmoset brain and provided an open MRI database on marmosets with a wide age range. The Brain/MINDS Marmoset Brain MRI Dataset contains brain MRI information on 216 marmosets aged between 1 and 10 years. During its release date, it is the largest public dataset worldwide. Further, it comprises multi contrast MRI images. In addition, 91 of 216 animals have corresponding ex vivo high-resolution MRI datasets. Our MRI database, which is available at the Brain/MINDS Data portal might help understand the effects of different factors, such as age, sex, body size, and fixation, on the brain. Moreover, it can contribute to and accelerate brain science studies worldwide. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

PaperPlayer biorxiv neuroscience
Single-cell RNA-seq reveals stepwise fate conversion of supporting cells to hair cells in the chick auditory epithelium

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Aug 26, 2022


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.08.25.505256v1?rss=1 Authors: Matsunaga, M., Yamamoto, R., Kita, T., Ohnishi, H., Yamamoto, N., Okano, T., Omori, K., Nakagawa, T. Abstract: In contrast to mammals, the avian cochlea, specifically the basilar papilla, can regenerate sensory hair cells, which involves fate conversion of supporting cells to hair cells. To determine the mechanisms for converting supporting cells to hair cells, we used single-cell RNA sequencing during hair cell regeneration in explant cultures of chick basilar papillae. We identified dynamic changes in the gene expression of supporting cells, and the pseudotime trajectory analysis demonstrated the stepwise fate conversion from supporting cells to hair cells. Initially, supporting cell identity was erased and transition to the precursor state occurred. A subsequent gain in hair cell identity progressed together with downregulation of precursor-state genes. Transforming growth factor beta receptor 1-mediated signaling was involved in induction of the initial step, and its inhibition resulted in suppression of hair cell regeneration. Our data provide new insights for understanding fate conversion from supporting cells to hair cells in avian basilar papillae. Copy rights belong to original authors. Visit the link for more info Podcast created by PaperPlayer

Leaders Of Consulting
Terumi Okano: Grow With Authenticity

Leaders Of Consulting

Play Episode Listen Later Feb 16, 2022 27:38


Terumi Okano talks about pricing her services to fit her lifestyle and gaining the confidence to start her own business. We also hear about how she attracts her ideal clients organically and the importance of frameworks to better serve clients. Mentioned on the episode: https://www.bostontechcreative.com/ (Boston Tech Creative) Connect with Terumi on https://www.linkedin.com/in/terumiokano/ (LinkedIn), https://www.facebook.com/tworoomie (Facebook), and https://www.instagram.com/bostontechcreative/ (Instagram)! https://www.clarifyyourmessage.com/terumi (Terumi Okano Official Website)

authenticity okano terumi
The Wardroom Podcast
No Progress Without Honesty - RDML Okano, LCDR Carino, LCDR Macus

The Wardroom Podcast

Play Episode Listen Later Feb 16, 2021 36:04


We are joined by: Rear Admiral Seiko Okano, Program Executive Officer for Integrated Warfare Systems Lieutenant Commander Christina Carino, Action Officer, Deputy Assistant Secretary of the Navy - Ships Lieutenant Commander Rebecca Macus, Test & Trials Director, Amphibious Warfare Program Office for a discussion on bias, unique challenges for women, and leadership lessons applicable to all.   Book Recommendations:   RDML Okano's "must-read": The Kill Chain: Defending America in the Future of High-Tech Warfare by Christian Brose   How to change and adapt to culture:  The Culture Code: The Secrets of Highly Successful Groups by Daniel Coyle Range: Why Generalists Triumph in a Specialized World by David Epstein Loonshots: How to Nurture the Crazy Ideas That Win Wars, Cure Diseases, and Transform Industries by Safi Bahcall   On Empathy: The War for Kindness: Building Empathy in a Fractured World by Jamil Zaki   EDO Book Club  If you have not yet joined the Slack workspace, join by finding the invite link in the "Book Club Announcement" on EDO Main. ED LDF

King of Kanto
Episode 22 - Chris Okano

King of Kanto

Play Episode Listen Later Nov 30, 2020 81:41


Chris OkanoA segment!Cam comes in late (fucker).Japanator is touched upon, but MicroKok incoming!Kathy Kat, your favorite Jvlogger (apparently) releases a cringe top ten list.Daniel Lord exchanges cereal for cheesecake.Nobita tries to protect gaijin from toxic Japanese women.Tkyosam kicks Jay out of Sam’s Discord group. Sam also says that KoK needs to “do their research”. An untrue statement that Jay ended up taking way too fucking seriously!Yes sir! That is one fine looking A segment.Segment BUnlike our regular jvlogger flunkies, who grow up dirt poor and try to etch out a life with zero skills, Chris Okano was born to money, and still wound up with zero skills. Okano like all jvloggers creates content layered in dullness and unawareness. But the insidiousness of a Chris has another layer, he is a gigantic tit that has given milk to other jvloggers and is partially responsible for the current Jvlog industry.Previous nominee Jvloggers such as Sharla and Kelly Morita are actually employees of his old company Tokyo Creative. And the sponsorships might actually play a hand in the gross spread of misinformation that Jvloggers espouse.Segment B takes a dry departure from our regular comedic content. It is the result of a fall down a rabbit hole, but leads to some rich understanding of the “why” of Jvlogging.

Talks On Psychoanalysis
Kenichiro Okano - A Japanese psychoanalyst concerned with shame and dissociation.

Talks On Psychoanalysis

Play Episode Listen Later Oct 28, 2020 17:13


In this episode Dr. Kenichiro Okano displays how shame and social phobia could manifest differently between the Eastern and the Western countries, and investigates them from a psychoanalytical point of view. With his personal history of becoming a bicultural psychiatrist and psychoanalyst in the United States and in Japan, he considers that while passivity and non-action induced by shame can be misunderstood in Western culture, it can potentially exert some paradoxical power and influence, at least in the Japanese society. In its conceptualizations, the dissociation construct plays a central role, consistent with its research and clinical experience. Dr Kenichiro Okano is a Japanese psychiatrist and psychoanalyst, and professor of Clinical Psychology at Kyoto University Department of Education. He is a training and supervising analyst in the Japan Psychoanalytic Society. He is the author of 26 books on psychoanalysis, dissociative disorder, and neurobiology. In 2016 he won The Japanese Psychoanalytical Association’s Distinguished Publications Award.This episode is availablealso in Japanese

PaperPlayer biorxiv neuroscience
The polymicrogyria-associated GPR56 promoter preferentially drives gene expression in developing GABAergic neurons in common marmosets

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Oct 22, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.10.21.348821v1?rss=1 Authors: Murayama, A. Y., Kuwako, K.-i., Okahara, J., Bae, B.-I., Okuno, M., Mashiko, H., Shimogori, T., Walsh, C. A., Sasaki, E., Okano, H. Abstract: GPR56, a member of the adhesion G protein-coupled receptor family, is abundantly expressed in cells of the developing cerebral cortex, including neural progenitor cells and developing neurons. The human GPR56 gene has multiple presumptive promoters that drive the expression of the GPR56 protein in distinct patterns. Similar to coding mutations of the human GPR56 gene that may cause GPR56 dysfunction, a 15-bp homozygous deletion in the cis-regulatory element upstream of the noncoding exon 1 of GPR56 (e1m) leads to the cerebral cortex malformation and epilepsy. To clarify the expression profile of the e1m promoter-driven GPR56 in primate brain, we generated a transgenic marmoset line in which EGFP is expressed under the control of the human minimal e1m promoter. In contrast to the endogenous GPR56 protein, which is highly enriched in the ventricular zone of the cerebral cortex, EGFP is mostly expressed in developing neurons in the transgenic fetal brain. Furthermore, EGFP is predominantly expressed in GABAergic neurons, whereas the total GPR56 protein is evenly expressed in both GABAergic and glutamatergic neurons, suggesting the GABAergic neuron-preferential activity of the minimal e1m promoter. These results indicate a possible pathogenic role for GABAergic neuron in the cerebral cortex of patients with GPR56 mutations. Copy rights belong to original authors. Visit the link for more info

CB.Poder
CB. Saúde: médico Hiroshi Okano, coordenador da mastologia do Hospital São Francisco de Ceilândia (Outubro Rosa) - 22/10

CB.Poder

Play Episode Listen Later Oct 22, 2020 20:06


CB Saúde com Humberto Rezende e Hudson Hiroshi Okano, coordenador da mastologia do Hospital São Francisco de Ceilândia. Além do atendimento no HSFC, ele atua voluntariamente na conscientização do diagnóstico precoce do câncer de mama.

CB.Poder
Mitos e verdades sobre o câncer de mama, com o mastologista Hudson Okano

CB.Poder

Play Episode Listen Later Oct 22, 2020 12:38


Mitos e verdades sobre o câncer de mama, com o médico Hudson Okano, coordenador da mastologia do Hospital São Francisco de Ceilândia. Além do atendimento no HSFC, ele atua voluntariamente na conscientização do diagnóstico precoce do câncer de mama.

Interview Podcast – Echoes
Echoes Podcast: CGT, Hiroki Okano, Silver Apples

Interview Podcast – Echoes

Play Episode Listen Later Sep 10, 2020 35:19


CGT, Hiroki Okano, Simeon Coxe

Tecendo Redes
Vidas Declaradas - Nilza Okano

Tecendo Redes

Play Episode Listen Later Sep 4, 2020 9:40


No episódio de hoje, você vai conhecer a história de Nilza Okano, apresentadora do programa Tecer Idades. Ela conta sobre sua juventude, sua vida, filhos e deixa um conselho especial para os jovens.

PaperPlayer biorxiv bioinformatics
Integrated Collection of Stem Cell Bank data, a data portal for standardized stem cell information

PaperPlayer biorxiv bioinformatics

Play Episode Listen Later Aug 27, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.26.263830v1?rss=1 Authors: Chen, Y., Sakurai, K., Maeda, S., Masui, T., Okano, H., Dewender, J., Seltmann, S., Kurtz, A., Masuya, H., Nakamura, Y., Sheldon, M., Schneider, J., Stacey, G., Panina, Y., Fujibuchi, W. Abstract: The last decade has witnessed an extremely rapid increase in the number of newly established stem cell lines worldwide. However, due to the lack of a standardized format, data exchange among stem cell line information resources has been challenging, and no system can search all stem cell lines across resources worldwide. To solve this problem, we have developed the Integrated Collection of Stem Cell Bank data (ICSCB) (http://icscb.stemcellinformatics.org/), a new and largest database search portal for stem cell line data from various resources, based on the standardized data items and terms of the MIACARM framework. Currently, ICSCB can retrieve 15,796 cell lines from four major data resources in Europe, Japan, and the U.S. ICSCB is automatically updated to provide the latest cell line information, and its integrative search engine helps users collect cell line information from donors with rare diseases worldwide, which has been a formidable task, thereby distinguishing itself from other database search portals. Copy rights belong to original authors. Visit the link for more info

PaperPlayer biorxiv neuroscience
The Japan Monkey Centre Primates Brain Imaging Repository of high-resolution postmortem magnetic resonance imaging: the second phase of the archive of digital records

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Aug 24, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.23.263517v1?rss=1 Authors: Sakai, T., Hata, J., Shintaku, Y., Ohta, H., Sogabe, K., Mori, S., Okano, H. J., Hamada, Y., Hirabayashi, T., Minamimoto, T., Sadato, N., Okano, H., Oishi, K. Abstract: A comparison of neuroanatomical features of the brain between humans and our evolutionary relatives, nonhuman primates, is key to understanding the human brain system and the neural basis of mental and neurological disorders. Although most comparative MRI studies of human and nonhuman primate brains have been based on brains of primates that had been used as subjects in experiments, it is essential to investigate various species of nonhuman primates in order to elucidate and interpret the diversity of neuroanatomy features among humans and nonhuman primates. To develop a research platform for this purpose, it is necessary to harmonize the scientific contributions of studies with the standards of animal ethics, animal welfare, and the conservation of brain information for long-term continuation of the field. In previous research, we first developed an open-resource repository of anatomical images obtained using 9.4-T ex vivo MRI of postmortem brain samples from 12 nonhuman primate species, and which are stored at the Japan Monkey Centre. In the present study, as a second phase, we released a collection of T2-weighted images and diffusion tensor images obtained in nine species: white-throated capuchin, Bolivian squirrel monkey, stump-tailed macaque, Tibet monkey, Sykes' monkey, Assamese macaque, pig-tailed macaque, crested macaque, and chimpanzee. Our image repository should facilitate scientific discoveries in the field of comparative neuroscience. This repository can also promote animal ethics and animal welfare in experiments with nonhuman primate models by optimizing methods for in vivo and ex vivo MRI scanning of brains and supporting veterinary neuroradiological education. In addition, the repository is expected to contribute to conservation, preserving information about the brains of various primates, including endangered species, in a permanent digital form. Copy rights belong to original authors. Visit the link for more info

PaperPlayer biorxiv neuroscience
Starburst amacrine cells amplify optogenetic visual restoration through gap junctions in the murine retina

PaperPlayer biorxiv neuroscience

Play Episode Listen Later Aug 12, 2020


Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.08.11.246686v1?rss=1 Authors: Katada, Y., Kunimi, H., Kobayashi, K., Okano, H., Tanaka, K. F., Tsubota, K., Kurihara, T. Abstract: Ectopic induction of optogenetic actuators, such as channelrhodopsin, is a promising approach to restore vision in the degenerating retina. However, the cell type-specific response of ectopic photoreception has not been well understood. It is not easy to obtain efficient gene expression in a specifically targeted cell population by a transgenic approach. In the present study, we established retinal ganglion cell (RGC)- and amacrine cell gene induction in a murine model with high efficiency using an improved tetracycline transactivator-operator bipartite system (KENGE-tet system). To investigate the cell type-specific visual restoration effect, we expressed the channel rhodopsin gene into RGCs and amacrine cells using this system. Then, enhancement of the visual restoration effect was observed by gene transfer not only to RGCs but also to starburst amacrine cells. It was suggested that photoresponse from amacrine cells enhanced the maintained response of ganglion cells and furthered the visual restoration effect. Copy rights belong to original authors. Visit the link for more info

dokupied podcast - anime, manga, light novels, industry news
20 – The Unwanted Undead Adventurer by Yu Okano

dokupied podcast - anime, manga, light novels, industry news

Play Episode Listen Later Jul 2, 2020 34:46


Several new tv anime series were announced this week. Science Saru and Masaaki Yuasa's upcoming film Inu-Oh was licenses by GKIDS. And Yen Press and Seven Seas announced a bunch of new manga and light novel licenses. Light novel recommendation: The Unwanted Undead Adventurer by Yu Okano Music Orbiting A Distant Planet by Quantum Jazz Eclosion by Salmo Check out my website. It has links to all my stuff: dokupe.com Follow dokupied on podcast.dokupe.com, subscribe and review wherever you listen to podcasts!

Quarantine Phone Calls
Terumi Okano: Owner, Boston Tech Creative - Boston, USA

Quarantine Phone Calls

Play Episode Listen Later Mar 27, 2020 11:55


Terumi's Website // Join our Virtual Coworking Community for free today. // Interview by Matthew Thompson --- Send in a voice message: https://anchor.fm/quarantine-phone-calls/message

808 Podcast
#196 Keith Okano w Closing Strong Coaching

808 Podcast

Play Episode Listen Later Mar 18, 2020 6:54


Keith tells you how use to use purpose to leverage your business. You can check him out at https://ClosingStrong.com/

coaching okano
Fala Behring | Jiu-Jitsu
Mate suas dúvidas | #039 Fala Behring & Goshinjutsukan

Fala Behring | Jiu-Jitsu

Play Episode Listen Later Feb 24, 2020 5:16


Gustavo Goulart responde as dúvidas da nossa audiência 1- Maeda teve contato com Okano Kotaro? 2- Maeda teve contato com Tanabe? 3- Se o Okano Kotaro, Oda , Kanemitsu tiveram contato com Tanabe? 4- Quem ensinou Oda, Okano e Kanmitsu que foram os pais do Kosen? --- Send in a voice message: https://anchor.fm/behringjiujitsu/message

The Weekly Business Hour with Rick Schissler
1.20.20 – Keith Okano P.3 – The Weekly Business Hour

The Weekly Business Hour with Rick Schissler

Play Episode Listen Later Jan 21, 2020 50:10


1.20.20 – Keith Okano P.3 – The Weekly Business Hour – LIVE Lone Star Community Radio Join us for Part III of our Soup to Nuts series “Creating Your Plan for Your Purpose” with Keith Okano, [...]

The Weekly Business Hour with Rick Schissler
1.13.20 – Keith Okano Pt.2 – The Weekly Business Hour

The Weekly Business Hour with Rick Schissler

Play Episode Listen Later Jan 13, 2020 54:37


Join us for Part II of our Soup to Nuts series “Creating Your Plan for Your Purpose” with Keith Okano, founder of Closing Strong and author of “Personal Purpose Process: Creating Your Plan For Your [...]

Come to the Table
Blind Justice with Christopher Okano

Come to the Table

Play Episode Listen Later Jan 9, 2020 89:47


Ever had a conversation with a person who has been to prison, convicted of a felony and served their time? Would serving their sentence be enough for you to treat them like everyone else? We have a conversation with Christopher Okano, his felony conviction, his time in prison and what it has been like since he got out. Love in action is listening to understand, not to react. You can find us on different mediums to listen and subscribe such as iTunes, Spotify, Google Play Music, TuneIn,  iHeart Radio, PodBean, Cast Box and more by clicking here. We are very anxious to hear YOUR feedback at our first jump into this and want to hear the good and bad so we can keep doing the right things correctly and correct the things we are not. Please contact us at sean@thecometothetablepodcast.com for any and all feedback, comments, show suggestions and the like.  You can also like our Facebook Page  as well as follow us on Instagram & Twitter  A special thanks to the musical talent of our friend and guest of the show David HaLevy for writing and performing the sound to our intro and outgoing music.  Check out the Ruach Guitar Facebook Page he makes by hand and plays as well as on Instagram.   We are very humbled and grateful for this personal touch to the show and cherish it greatly.   תודה David!

The Weekly Business Hour with Rick Schissler
1.6.20.19 – Keith Okano P.1 – The Weekly Business Hour

The Weekly Business Hour with Rick Schissler

Play Episode Listen Later Jan 6, 2020 55:07


Join us as we kick off the New Year with an ALL NEW episode of The Weekly Business Hour! We will be talking with Keith Okano, author of “Personal Purpose Process: Creating Your Plan For [...]

Crazy Funny Asianz: Hosted by Miscellaneous Brown
Crazy Funny Asianz Episode 7: Always Be My Maybe Too: Electric Boogaloo- EDELYN OKANO

Crazy Funny Asianz: Hosted by Miscellaneous Brown

Play Episode Listen Later Jul 15, 2019 65:45


Join Miscellaneous Brown a.k.a. Erick Esteban for a great conversation with Filipina/Japanese Canadian Actress EDELYN OKANO. Listen to her Crazy Funny Asianz Story from improvising her way onto one of Erick's Minny Pacquiao episodes to being a part go the groundbreaking cast of East West players Mama Mia. They also discuss the state of Asian American Hollywood, Scarlett Johansen's latest comments, and Erick pitches his Edelyn a script idea.Support the show (https://www.patreon.com/erickesteban)

Café Clingendael
Maaike Okano-Heijmans on the Dutch China Strategy

Café Clingendael

Play Episode Listen Later May 17, 2019 12:21


Maaike Okano-Heijmans on the China Strategy of the Dutch government, released on 15 May 2019.

Heroes Garage
Marvel Runaways Review And Stan Lee Tribute

Heroes Garage

Play Episode Listen Later Nov 20, 2018 56:55


Tom and Bill talk Runaways Tribute to Stan Lee 4:30-10:00 Runaways Season 1 review (Spoilers) 10:00-39:53 Preview Runaways Season 2 Notes: Main Rhenzy Feliz as Alex Wilder: A nerd who longs to reunite with his childhood friends. He has a high intellect and is the leader of the Runaways.[4] Lyrica Okano as Nico Minoru: A Wiccan who isolates herself with her gothic appearance and is a member of the Runaways.[4] Unlike the comics, Nico does not summon the Staff of One through self-harm. Okano said this was tweaked, "for good reason" as there would be "a lot of young teenagers watching the show and we don't want to promote anything like self-harm because that's serious". She added that an element of drawing blood would still be involved.[5] Virginia Gardner as Karolina Dean: A human-alien hybrid burdened by her religious upbringing who wants to pursue her own desires instead of following in her mother's footsteps, and is a member of the Runaways.[4] Karolina has the ability of flight, to glow with rainbow-colored light, and to shoot beams of light.[6] Ariela Barer as Gert Yorkes: A riot grrrl, social activist, and a member of the Runaways. She also has a telepathic link with her genetically engineered dinosaur, Old Lace.[4] Gregg Sulkin as Chase Stein: A high school lacrosse player who is often dismissed as a dumb jock, but displays brilliance in engineering and is a member of the Runaways.[4] Sulkin and the writers wanted the character to be "more layered" than the comics, and Sulkin felt that Chase was the most changed of the Runaways from the source material.[7] The character is depicted as having the potential to be as much of a genius as his father is,[8] and builds gadgets, including powerful weaponized gauntlets called "Fistigons".[9] Connor Falk portrays a young Chase.[10] Allegra Acosta as Molly Hernandez: The youngest member of the Runaways who is characterized by her positive attitude. Molly discovers she has the ability of superhuman strength and invulnerability.[4] Evelyn Angelos portrays a young Molly.[11] Angel Parker as Catherine Wilder: Alex's mother, a successful lawyer, and a member of Pride.[2] Ryan Sands as Geoffrey Wilder: Alex's father and a self-made businessman who had a grueling path to his success and is a member of Pride.[2] Annie Wersching as Leslie Dean: Karolina's mother, one of the leaders of the cult-like religious group, the Church of Gibborim, and a member of Pride.[2][12] Kip Pardue as Frank Dean: Karolina's father, a former teen star who is struggling in his professional acting career and becomes one of the leaders of the Church of Gibborim.[2][12] Ever Carradine as Janet Stein: Chase's mother who has a brilliant mind, is "a perfect PTA mom", and a member of Pride.[2] Sorel Carradine portrays a young Janet.[10] James Marsters as Victor Stein: Chase's father, an engineering genius and a member of Pride.[2] Marsters was inspired by Vincent D'Onofrio's portrayal of Wilson Fisk in Daredevil, saying it was "exactly opposite of what I was expecting", and also looked for common ground with Victor, saying, "I'm not an abusive parent but I'm not a perfect parent. I don't think anyone is." He added that Victor just wants Chase to live up to his potential.[8] Tim Pocock portrays a young Victor.[10] Brigid Brannagh as Stacey Yorkes: Gert's mother, a bioengineer, and a member of Pride.[2] Kevin Weisman as Dale Yorkes: Gert's father, a bioengineer, and a member of Pride.[2] Brittany Ishibashi as Tina Minoru: Nico's mother who is a brilliant innovator, ruthless CEO, and perfectionist "tiger mom" who is a member of Pride.[2] The character previously appeared in the film Doctor Strange, in a minor role as a Master of the Mystic Arts, portrayed by Linda Louise Duan.[13][14][15] The producers felt free to recast the role and create a different version of Tina Minoru since Duan was not named as the character in the film.[16] James Yaegashi as Robert Minoru: Nico's father and a member of Pride who is a brilli Become a supporter of this podcast: https://anchor.fm/tom-zimm7/support This podcast is sponsored by Flipboard

Heroes Garage
Marvel Runaways Review and Stan Lee Tribute

Heroes Garage

Play Episode Listen Later Nov 20, 2018 56:33


Tom and Bill talk Runaways Tribute to Stan Lee 4:30-10:00 Runaways Season 1 review (Spoilers) 10:00-39:53 Preview Runaways Season 2 Notes: Main Rhenzy Feliz as Alex Wilder: A nerd who longs to reunite with his childhood friends. He has a high intellect and is the leader of the Runaways.[4] Lyrica Okano as Nico Minoru: A Wiccan who isolates herself with her gothic appearance and is a member of the Runaways.[4] Unlike the comics, Nico does not summon the Staff of One through self-harm. Okano said this was tweaked, "for good reason" as there would be "a lot of young teenagers watching the show and we don't want to promote anything like self-harm because that's serious". She added that an element of drawing blood would still be involved.[5] Virginia Gardner as Karolina Dean: A human-alien hybrid burdened by her religious upbringing who wants to pursue her own desires instead of following in her mother's footsteps, and is a member of the Runaways.[4] Karolina has the ability of flight, to glow with rainbow-colored light, and to shoot beams of light.[6] Ariela Barer as Gert Yorkes: A riot grrrl, social activist, and a member of the Runaways. She also has a telepathic link with her genetically engineered dinosaur, Old Lace.[4] Gregg Sulkin as Chase Stein: A high school lacrosse player who is often dismissed as a dumb jock, but displays brilliance in engineering and is a member of the Runaways.[4] Sulkin and the writers wanted the character to be "more layered" than the comics, and Sulkin felt that Chase was the most changed of the Runaways from the source material.[7] The character is depicted as having the potential to be as much of a genius as his father is,[8] and builds gadgets, including powerful weaponized gauntlets called "Fistigons".[9] Connor Falk portrays a young Chase.[10] Allegra Acosta as Molly Hernandez: The youngest member of the Runaways who is characterized by her positive attitude. Molly discovers she has the ability of superhuman strength and invulnerability.[4] Evelyn Angelos portrays a young Molly.[11] Angel Parker as Catherine Wilder: Alex's mother, a successful lawyer, and a member of Pride.[2] Ryan Sands as Geoffrey Wilder: Alex's father and a self-made businessman who had a grueling path to his success and is a member of Pride.[2] Annie Wersching as Leslie Dean: Karolina's mother, one of the leaders of the cult-like religious group, the Church of Gibborim, and a member of Pride.[2][12] Kip Pardue as Frank Dean: Karolina's father, a former teen star who is struggling in his professional acting career and becomes one of the leaders of the Church of Gibborim.[2][12] Ever Carradine as Janet Stein: Chase's mother who has a brilliant mind, is "a perfect PTA mom", and a member of Pride.[2] Sorel Carradine portrays a young Janet.[10] James Marsters as Victor Stein: Chase's father, an engineering genius and a member of Pride.[2] Marsters was inspired by Vincent D'Onofrio's portrayal of Wilson Fisk in Daredevil, saying it was "exactly opposite of what I was expecting", and also looked for common ground with Victor, saying, "I'm not an abusive parent but I'm not a perfect parent. I don't think anyone is." He added that Victor just wants Chase to live up to his potential.[8] Tim Pocock portrays a young Victor.[10] Brigid Brannagh as Stacey Yorkes: Gert's mother, a bioengineer, and a member of Pride.[2] Kevin Weisman as Dale Yorkes: Gert's father, a bioengineer, and a member of Pride.[2] Brittany Ishibashi as Tina Minoru: Nico's mother who is a brilliant innovator, ruthless CEO, and perfectionist "tiger mom" who is a member of Pride.[2] The character previously appeared in the film Doctor Strange, in a minor role as a Master of the Mystic Arts, portrayed by Linda Louise Duan.[13][14][15] The producers felt free to recast the role and create a different version of Tina Minoru since Duan was not named as the character in the film.[16] James Yaegashi as Robert Minoru: Nico's father and a member of Pride who is a brilli --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/tom-zimm7/message Support this podcast: https://anchor.fm/tom-zimm7/support

New Books Network
Kaori Okano and Yoshio Sugimoto, eds., “Rethinking Japanese Studies: Eurocentrism and the Asia-Pacific Region” (Routledge, 2018)

New Books Network

Play Episode Listen Later May 1, 2018 49:39


Rethinking Japanese Studies. Eurocentrism and the Asia-Pacific Region (Routledge, 2018) is co-edited by Kaori Okano and Yoshio Sugimoto. The book tries to look at the discipline of Japanese Studies from a variety of perspectives and in a variety of contexts, starting from the premise that – as the authors put it – Japanese Studies is not the exclusive property of the anglophone world. In the volume, the authors try to answer several key questions: * What variations are there among the academic communities of Japanese Studies in Asia? * Is there a local intellectual approach that displays a degree of autonomy from the global scholarship in the English-using world? * In what ways have some academic disciplines or approaches been affected by Anglo-Western scholarship to a greater extent than others? Why? * What are the potential contributions of Japanese Studies in the Asia-Pacific to Japanese Studies globally? In the interview, co-editor Kaori Okano answers some of these questions. Learn more about your ad choices. Visit megaphone.fm/adchoices

New Books in East Asian Studies
Kaori Okano and Yoshio Sugimoto, eds., “Rethinking Japanese Studies: Eurocentrism and the Asia-Pacific Region” (Routledge, 2018)

New Books in East Asian Studies

Play Episode Listen Later May 1, 2018 49:39


Rethinking Japanese Studies. Eurocentrism and the Asia-Pacific Region (Routledge, 2018) is co-edited by Kaori Okano and Yoshio Sugimoto. The book tries to look at the discipline of Japanese Studies from a variety of perspectives and in a variety of contexts, starting from the premise that – as the authors put... Learn more about your ad choices. Visit megaphone.fm/adchoices

Filmcast Without A Cause
FWOAC 189: Runaways

Filmcast Without A Cause

Play Episode Listen Later Dec 6, 2017 41:51


FWOAC investigates the suspicious parental happenings in Hulu's new Marvel series, Runaways.

Comic News Insider
Episode 817 - NYCC: The Runaways w/ Lyrica Okano/Virginia Gardner/Ariela Barer/Allegra Acosta/Rhenzy Feliz/Gregg Sulkin/Producers Josh Schwartz/Stephanie Savage/Jeph Loeb!

Comic News Insider

Play Episode Listen Later Nov 11, 2017 41:45


It's the last of the NYCC press room roundtables! Jimmy sat in on this one for Hulu's new show Runaways based on the hit Marvel comics series.  You'll hear from stars Lyrica Okano, Virginia Gardner, Ariela Barer, Allegra Acosta, Rhenzy Feliz, Gregg Sulkin and Producers Josh Schwartz, Stephanie Savage, Jeph Loeb! How close to the comic book source will the series be? What changes for the characters have been made? Will we be seeing a lot of Old Lace? Download it and find out! Leave your iTunes comments! 5 stars and nothing but love! Also, get a hold of us! Thanks for listening!

The Startup Catalyst
Episode 107 - Sean Ho`okano-Briel, CEO and Co-Founder at Comprendio

The Startup Catalyst

Play Episode Listen Later Jun 10, 2016 65:10


In this episode of The Startup Catalyst Podcast, we welcome Sean Ho`okano-Briel, CEO and Cofounder of ed tech platform Comprendio. Sean is a consummate teacher, and he's got some really great nuggets in this show. We talk about launching Comprend.io, tools and sales processes they're trying out, his love for Hawaii and respect for the ocean, and you will get some great insights into Sean's mental models and frameworks for approaching problems and opportunities. If you'd like to get updates on new episodes right when the come out then sign up for the newsletter. Just head over to www.sultanventures.com and scroll down to the footer where you can input your email. Please share this episode, subscribe, rate and review on iTunes! This is the Startup Catalyst Podcast brought to you by Sultan Ventures, I am your host Luke Tucker signing off, tune in next Thursday for another bomb-diggity episode where we chat with Chenoa Farnsworth, Managing Director at Blue Startups and Hawaii Angels --- Support this podcast: https://anchor.fm/startup-catalyst-podcast/support

Design Talk Hawaii
Lauren Okano, Maggie Engebretson - "Hidden Treasures of Hawaii" (11-20-15)

Design Talk Hawaii

Play Episode Listen Later Nov 20, 2015 52:50


Matt chats with artist/educator Lauren Okano and publicist Maggie Engebretson about the exciting 9-artist Pop-Up Art exhibition entitled "Hidden Treasures of Hawaii." http://www.laurenokanoart.com/laurenokanoart

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 02/06
Functional Analysis of DNA Methylation in Development and Disease

Fakultät für Biologie - Digitale Hochschulschriften der LMU - Teil 02/06

Play Episode Listen Later May 30, 2006


The genome of mammals harbors chemical modifications at some cytosine residues in the form of a methyl group. These modified residues, termed 5’-methylcytosines, have been discovered more than 50 years ago (Hotchkiss 1948) and have since been shown to play important roles in the regulation of gene expression and in the execution of developmental programs. Patterns of cytosine methylation (also referred to as DNA methylation) are carefully set and preserved during cellular expansion and global methylation levels are well regulated throughout development. Changes in methylation patterns and levels have been associated with disease progression and death (Li et al. 1992; Okano et al. 1999; Ehrlich 2002). Specifically, elevated levels of global genomic methylation have been shown to play a role in the inactivation of tumor suppressor genes in many types of cancer (Ehrlich 2002). In contrast, reduced levels of methylation have been observed in a wide variety of tumors and complete demethylation in vivo causes embryonic death (Li et al. 1992; Ehrlich 2002). In an effort to study the effect of changed methylation levels in vivo and its effect on disease progression, we developed a genetic approach to study the effect of hypomethylation during embryogenesis and adulthood. DNA methyltransferase 1 (Dnmt1) is the major methyltransferase in mammals and genetic inactivation of the Dnmt1 gene causes demethylation that results in cell death in tissue culture and embryonic lethality of homozygous mutant mice at E8.5 (Li et al. 1992). In a first step, the 5’ end of the Dnmt1 gene was characterized to determine the structure of a new oocyte-specific isoform found in oocytes and early embryos. Upon elucidation of the structure of this isoform, assays were developed to test its function in vivo. Loss of this oocyte-specific isoform protein resulted in hypomethylation of an IAP reporter element suggesting a role for this protein in early development. In contrast, the somatic Dnmt1 isoform, which is present in all somatic cells, was important for maintaining this IAP element methylated following implantation of the embryo and throughout adulthood. Reduced levels of Dnmt1 in adults caused global hypomethylation and resulted in the development of thymic lymphomas which displayed a duplication of chromosome 15 (trisomic 15). The c-myc oncogene, which resides on chromosome 15, was overexpressed, and a gene expression array analysis revealed that another oncogene, Notch-1, was also overexpressed in all tumors. Cooperation between those oncogenes has been previously shown to induce thymic lymphomas. Analysis of the Notch-1 locus demonstrated the presence of IAP insertions upstream of the oncogenic cytoplasmic domain capable of activating transcription of truncated oncogenic Notch-1. IAP elements were shown to be activated by hypomethylation albeit not as much as traditional mutagenic retroviruses. These results thus show that hypomethylation may induce tumorigenesis in this model following two mechanisms. First by inducing chromosome instability and second by creating insertional mutagenesis of defective retroviral elements such as IAPs. These results demonstrate for the first time that hypomethylation can directly induce tumorigenesis in mice and induce chromosome instability.