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Welcome back to another episode of the Evidence-Based Hair Podcast! In this episode, we delve into a fascinating study on the use of generic tofacitinib for treating alopecia areata. This study, published in the Archives of Dermatologic Research, explores the effectiveness and safety of generic tofacitinib. With the recent availability of this cost-effective alternative in Canada, the study provides valuable insights into whether switching from brand name options (Xeljanz) is a viable choice for patients. The retrospective study included 20 patients with advanced alopecia areata, and the results were promising. A significant number of patients experienced noticeable improvements in hair regrowth, with low incidence of side effects. This episode discusses the study's findings and the broader implications for treatment options in alopecia areata. Join me as we explore how this study might change the landscape of hair loss treatment and what it means for patients and practitioners alike. Don't miss next week's episode, where we'll discuss the use of baricitinib in young children. STUDY REFERENCED Jian J et al. Effectiveness and safety of generic tofacitinib in alopecia areata: is the generic a cost-effective option? A retrospective study. Arch Dermatol Res. 2024 May 11;316(5):154. doi: 10.1007/s00403-024-02879-4.
Christopher Posner Chief Executive Officer, President, and Director Mr. Posner has served as our President and Chief Executive Officer since November 2021 and has served as a member of our Board since August 2018. He has broad experience in commercial and marketing operations and product management at both large and specialty pharmaceutical companies, where he has focused on products for autoimmune, inflammatory and pain conditions, including Xeljanz® and Enbrel®. From July 2017 to October 2021, he served as the Chief Executive Officer of LEO Pharma, Inc. US, a subsidiary of LEO Pharma A/S, a global healthcare company specializing in dermatology and critical care, including such conditions as psoriasis and atopic dermatitis. Prior to joining LEO, he was the Head of Worldwide Commercial Operations at R-Pharma-US, LLC, a specialty pharmaceutical company focused on oncology and chronic immune disorders, from 2014 until 2017. Previously, Mr. Posner held a variety of senior management positions in commercial and marketing operations at Bristol-Myers Squibb Company, Pfizer Inc., Wyeth Pharmaceuticals, Inc. and Endo Pharmaceuticals plc. Mr. Posner holds an M.B.A. from Fuqua School of Business, Duke University and a B.A. in Economics from Villanova University. Please see korsuva.com/pi for Full Prescribing Information.
Happy Friday!Join the girls as they discuss Chapter 11 of "Harry Potter, Book One": "Quidditch" - as well as our newest Patron, those pesky Xeljanz commercials, and some new insight from our resident detective, Casey-Jane! (Plus, it's Karyn's birthday!)
Biden's pick to run the FDA shows a revolving door between Big Pharma and federal regulators. Michigan residents receive a paltry settlement for the Flint water crisis. Litigation continues over cancer-causing Xeljanz and Valsartan pills.
How does Remdesivir plus standard of care compare to standard of care alone in patients hospitalized with COVID-19? Find out this and more in today's PVRoundup podcast.
Here are the links for everything discussed in Episode 68. Times are also below so feel free to skip around and get to the drugs that interest you. (1:18) Approval of Skytrofa a weekly human growth hormone (4:22) Invega Hayfera approved for schizophrenia (7:50) FDA issues new warning on JAK inhibitors Connect with The Rx Daily Dose:Twitter Instagram YouTube Linkedin WebsiteEmail: therxdailydose@gmail.comConnect with Ian Parnigoni PharmD. on social media:Twitter Instagram Linkedin ★ Support this podcast on Patreon ★
Sarc Fighter: Living with Sarcoidosis and other rare diseases
Dr. William Damsky, MD, Ph.D., is a leading researcher at Yale University. He is pioneering a study using the off label drug, Xeljanz (say:ZEL-janz) to fight sarcoidosis of the skin, with so far - great success. Damsky and his team have been able to make disfiguring cases of dermatological sarcoidosis disappear in a handful of cases. They are now moving ahead with a more robust clinical trial to see just how promising this treatment may be -- perhaps for sarcoidosis in other parts of the body as well. In this Episode of the Sarc Fighter podcast, Dr. Damsky explains in easy to understand terms how this drug works within the body to block the autoimmune response behind sarcoidosis. William Damsky MD, PhD Bio https://medicine.yale.edu/profile/william_damsky/?tab=bio Xeljanz https://www.xeljanz.com/ Background on the study at Yale School of Medicine https://medicine.yale.edu/news-article/yale-experts-treat-severe-disfiguring-sarcoidosis-with-novel-therapy/ Bonus Episode on COVID-19 and Sarcoidosis https://beatsarc.podbean.com/e/bonus-episode-sarcoidosis-and-covid-19-presented-by-the-foundation-for-sarcoidosis-research/ Bonus Episode Sarcoidosis and Prednisone https://beatsarc.podbean.com/e/bonus-episode-sarcoidosis-town-hall-dealing-with-prednisone-presented-by-the-foundation-for-sarcoidosis-research/ Cycling with Sarcoidosis http://carlinthecyclist.com/category/cycling-with-sarcoidosis/ Watch the Prednisone Town Hall on YouTube https://youtu.be/dNwbcBIyQhE More on aTyr Pharma: https://www.atyrpharma.com/ Do you like the official song for the Sarc Fighter podcast? It's also an FSR fundraiser! If you would like to donate in honor of Mark Steier and the song, Zombie, Here is a link to his KISS account. (Kick In to Stop Sarcoidosis) 100-percent of the money goes to the Foundation. https://stopsarcoidosis.rallybound.org/MarkSteier The Foundation for Sarcoidosis Research https://www.stopsarcoidosis.org/ Donate to my KISS (Kick In to Stop Sarcoidosis) fund for FSR https://stopsarcoidosis.rallybound.org/JohnCarlinVsSarcoidosis?fbclid=IwAR1g2ap1i1NCp6bQOYEFwOELdNEeclFmmLLcQQOQX_Awub1oe9bcEjK9P1E My story on Television https://www.stopsarcoidosis.org/news-anchor-sarcoidosis/ email me carlinagency@gmail.com Sarc Fighter Facebook Page https://www.facebook.com/SarcFighter/ Sarc Fighter on Instagram https://www.instagram.com/thesarcfighter/
E no episódio temos um eu aceito, Tiffany & Co cria anel de casamento para homens, falamos também sobre o #robotaxi na China.Você já conhece o primeiro desodorante adaptado para pessoas com deficiência visual e de membros superiores? Então venha ver o Degree Inclusive da Unilever. Quanto gasta a Farma em publicidade e quais foram os TOP 5 produtos que mais gastaram em 2020: Humira, Dupixent, Xeljanz, Skyrizi e OzempicTodas as Segundas!
Listen to FDA Drug Safety Podcast on Drug Safety Communication titled "Initial safety trial results find increased risk of serious heart-related problems and cancer with tofacitinib (Xeljanz, Xeljanz XR)
In today’s episode, 12-year Ulcerative Colitis Warrior Shelly Sulfrain shares her IBD journey and how an ileostomy gave her back her life. At the age of 29, Shelly was working as a pharmacist and enjoying life, having just finished school. Then, her first symptom of blood in her stool led her to a trip to the emergency room. It took a few more visits to her primary care doctor and eventually a gastroenterologist to finally diagnose Ulcerative Colitis. From there, she faced a number of highs and lows as she cycled through medications and faced life-threatening side effects throughout the course of her journey. Over the years, Shelly found brief periods of remission, but ultimately kept finding herself back in a flare and struggling to keep the symptoms away. She battled one major flare right before her wedding and found remission on Imuran while she carried her baby. But, after delivering a healthy baby boy, she went into her worst flare yet and was started on Remicade. Four years later, she experienced a life-threatening side effect. The brain fog she developed and difficulty in finding the right words were a result of her neurons not functioning properly; a rare side effect of Remicade. It also meant there was a chance that she might only have a few months to live. While an MRI confirmed that she was not facing death, the damage that had been done was not reversible. Her options for medications were dwindling and, for Shelly, it was a sign that the disease was getting worse and that it was winning. She went on to try Entivyo, Humira, and Xeljanz, but nothing worked. By this point, she was in a bad place emotionally and mentally and she leaned into meditation, prayer, and journaling to help her cope with the anxiety, stress, and depression. Finally, her doctor suggested surgery. While she dismissed the idea at first, after reaching out to a number of different ostomy advocates on Instagram, she was ready to consider it. She gave one last effort to exhaust all non-surgical options and sought the help of a functional medicine doctor. After she still couldn’t find relief, she was ready for surgery. Though she faced a number of complications after her first j-pouch surgery, a year later Shelly had an ileostomy and today is living life to the fullest. She’s gained a lot of insight over the years and although times may get tough and bleak, she recognizes that having a positive outlook is vital and encourages others to remember that they are not alone. Follow Shelly on Instagram at:https://www.instagram.com/shellsgotguts/@shellsgotguts
A lady tells us to research before we talk about the Biden tax plan. Where did the Flu go? Now George W. Bush supports Joe Biden? The Babylon Bee prophesies again! Jeffy has a new intro song for his ‘Chewing The Fat’ segment! Jeffy also wants to start a “know your body” campaign. A new study claims that perhaps we are not racist. Chicago Mayor, Lori Lightfoot, made a commercial stating that “science is back”. It’s 2020 and new animals just dropped! Reviewing Joe Biden and Kamala Harris acceptance speech. Will you be having people over for Thanksgiving during the pandemic? A list of the side effects of the pharmaceutical drug Xeljanz. Learn more about your ad choices. Visit megaphone.fm/adchoices
Here are the links for everything discussed in Episode 44, I'm also including times here so feel free to skip ahead to the topics that interest you. (1:20) Combination of Opdivo & Yervoy approved for mesothelioma (4:53) Nucala approved with new indication (8:08) New age group approved for Kalydeco (10:46) Xeljanz approved for pcJIA CDC updates on COVID-19 & influenza reportingConnect with The Rx Daily Dose:Twitter Instagram YouTube Linkedin WebsiteEmail: therxdailydose@gmail.comConnect with Ian Parnigoni PharmD. on social media:Twitter Instagram Linkedin ★ Support this podcast on Patreon ★
Welcome to another episode of 2 Minute Tuesdays. Does having alopecia areata make us more susceptible to the coronavirus or COVID-19?Everyone is individual. Our lifestyles will determine whether we are more at risk, but simply having alopecia areata does not make us more susceptible to getting it. If you have other underlying conditions, are on immunosupressants like Methotrexate or Xeljanz, to treat your alopecia, your system is suppressed and potentially more compromised. Consult the CDC for more information, and always consult with your physician for more specifics. This and the information here is not to be used in place of advice from a medical professional, but rest easy in knowing that alopecia areata alone does not make you a happy host for COVID-19.
People who live with Crohn’s disease or ulcerative colitis have more to consider when it comes to the workplace. The cost of inflammatory bowel disease (IBD) means that a comprehensive insurance plan is a must, which may limit job choices. A flare-up or complication that results in absences can lead to poor performance reviews or difficulties with supervisors or co-workers. How can people with IBD cope? Three women who live with IBD, Megan Starshak, Mary Elizabeth Ulliman, and Tina Aswani Omprakash, tell their stories about missing work, being underinsured, and changing jobs while managing IBD. Information discussed in this episode includes Clostridium difficile (C diff), pouchitis, Crohn’s and Colitis Foundation Help Center, IBD and the Americans With Disabilities Act, The Family and Medical Leave Act, and Financial Help for People with IBD. Select pharmaceutical company assistance programs: Cimzia (certolizumab Entyvio (vedolizumab Humira (adalimumab Inflectra (infliximab biosimilar Remicade (infliximab) Renflexis (Infliximab biosimilar Simponi (goliumumab Stelara (ustekinumab Tysabri (natalizumab Xeljanz (tofacitinib Find Megan Starshak on MeganStarshak.com, Twitter, and Instagram. Find Tina Aswani Omprakash on Own Your Crohn’s, Facebook, Twitter, and Instagram. Find Mary Elizabeth Ulliman on Instagram. Find The Great Bowel Movement on Facebook, Twitter, and Instagram. Find Amber J Tresca at AboutIBD.com, Verywell, Facebook, Twitter, Pinterest, and Instagram. Credits: Sound engineering courtesy Mac Cooney. "IBD Dance Party" ©Cooney Studio.
Here are the links for everything discussed in Episode 14. Xtandi added indication Xeljanz XR added indication Approval of Padcev for urothelial cancer Approval of Vyondys 53 for Duchenne Muscular dystrophy Vascepa approval to reduce the risk of cardiovascular events. Connect with The Rx Daily Dose:Twitter Instagram YouTube Linkedin WebsiteEmail: therxdailydose@gmail.comConnect with Ian Parnigoni PharmD. on social media:Twitter Instagram Linkedin ★ Support this podcast on Patreon ★
Listen to an audio podcast of the July 26, 2019 FDA Drug Safety Communication on FDA approval of Boxed Warning about increased risk of blood clots and death with higher dose of arthritis and ulcerative colitis medicine tofacitinib (Xeljanz, Xeljanz XR).
Safety trial finds risk of blood clots in the lungs and death with higher dose of tofacitinib (Xeljanz, Xeljanz XR) in rheumatoid arthritis patients; FDA to investigate
A conversation with a friend with ulcerative colitis (possibly Crohn's colitis) who is now facing surgery. He tried his best to avoid it including implementing some very unconventional things - diet, fecal transplant, a medication called Xeljanz (prior to FDA approval) and even hyperbaric oxygen therapy. He shares his insights and we will follow-up with him post surgery. #AgainstTheGrain
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