The Rheumatoid Solutions Podcast
Juvenile idiopathic arthritis often leads to a lifetime of treatments: today Stanka and her daughter Ella tell us about how they managed to reverse JIA symptoms by applying a modified version of the Paddison Program. For the transcription and for more helpful information visit http://www.rheumatoidsolutions.com Paddison Program for Rheumatoid Arthritis http://www.paddisonprogram.com/rheumatoid-arthritis Rheumatoid Support - http://www.rheumatoidsupport.com
ProspectiveDoctor | Helping you achieve your medical school dreams | AMCAS | MCAT
Dr. Erkeda DeRouen is joined by Dr. Jia Ng. She is a board-certified nephrologist and epidemiologist and today, she talks about the world of research for medical students. Dr. Jia describes the opportunities and procedures she encountered from doing research, as well as the conditions they need to be in for them to thrive in the field. [00:28] Introduction of Dr. Jia Ng [01:35] Transitioning and Opportunities in Research [03:18] Recommendation for Research Pursual [06:41] Importance of Research in Residency [11:51] Dr. Jia: Why the US over Australia? [15:47] How to Get Involved in Research Research Dr. Jia mentions that Research is more complex than students and experts should perceive. According to her, research is a field that not only takes on the basic know-hows of medicine, but also the data driving the knowledge that caters to how medicine works along the evolution of society. Research allows the industry to adapt new knowledge for medical practitioners to not only develop new medicines, but also the overall medical healthcare system application. These applications include the in and out flow of patient care from medications to consultations and prescriptions. For students who are interested to take up research, it's important to note that they will be tasked on training with groups and mentors, working on large amounts of data that can be published in order to help a certain medical field in terms of innovative solutions to customer-friendly applications. Paving Your Own Path Medical students will have the opportunity to pave their own path in the field of research. The field may seem simple, but the avenue students take to be where they want to be may be more complex than they think. The key to having control over the path you want in the field of research is working around the knowledge that you are familiar with. Familiarity comes in the form of how well you know the healthcare system within a certain area and region or the connections you have with that set location as well. While it's important not to look at it as a race, getting where you need to be in the industry takes time, and that is inevitable. You can connect more with Dr. Ng through her website and YouTube channel. To learn more about how MedSchoolCoach can help you along your medical school journey, visit us at Prospective Doctor or https://somedocs.com/. You can also reach us through our social media: Facebook: https://www.facebook.com/groups/somedocspublic Instagram: https://www.instagram.com/somedocs/
Thank you so much to Kyle for commissioning this episode!I'm really excited to be getting into this book, especially since we get some hopefulness with Thera coming out of her catatonic state and finding out that her children are alive and that Toof and Radia aren't the traitors they seemed to be.I'm really worried about Jia and Tiphan Huto though.Thanks for listening, and see you soon!
“You and me together? God doesn't have the balls to keep us out.” Leo is looking to send Miguel back to Solitary due to a lack of progress from his Em City informant. After being tasked with killing Burr by Morales, Miguel tries to strike a deal with Burr himself. However, a rejection leads to deadly consequences and Miguel leaving the unit once again. Weigert Corporation's "Aging Pill" experiment continues to cause friction amongst the staff as the inmates continue to take their dosage. While some appear to be showing no side-effects whatsoever, others are showing varying degrees of aging, which gets Ryan into a panic. It could be worse though, it's not like any of the test subjects have dropped dead. Oh wait… Leroy, now known as Salah Yudin, continues to plot to kill Said. He's presented with a golden opportunity, but he can he bring himself to do it? Omar gets starstruck following a chance meeting with Vahue. Feeling disrespected by Vahue's aloofness, and talking absolute shit in the process, Omar strikes out, determined to make a name for himself. The Refugees are prepared to be returned to China. Before that happens, Gongjin gets the opportunity to meet the man behind the people smuggling operation, Jia Kenmin. With his chance to gain revenge on Morales for Bian's murder having now past, Gongjin asks for Jia to prove himself to his people by murdering Morales. Supreme returns to Em City, not only adding to Ryan's panic, but leading to a revelation for Augustus regarding the night he was arrested. Following a confrontation in the showers which leaves Augustus in the hospital, and despite Keller's offer to help, Burr seeks his own brand of justice. The news of Hank's murder reaches Oz, jeopardising the progress made between Schillinger and Beecher. Schillinger, with a little convincing from Robson, goes on the offensive, resulting in a visiting Angus being stabbed. As tensions continue to rise, Keller confides in Cloutier that it was he that ordered the hit on Hank, and that Beecher is innocent. Believing Keller's confession, Cloutier finds Schillinger before any more blood can be spilled. In two minds about what to truly believe, Schillinger meets with Beecher in one last attempt to end the bloodshed. With the Hatchet seemingly buried, Beecher and Keller say their goodbyes as Keller is shipped off to Massachusetts to stand trial. Also on this episode: Rebadow goes to bat for Busmalis, Len Lopresti: Car Salesman, we go for a walk down Doyers St, Ray returns from retreat, the inclusion of a deleted scene could really help the flow of things, and Dean Winters attempts to sing, bringing a controversial opinion to the surface. All of this and more on the Series 4(B) Episode 12, Cuts Like A Knife Follow the show on Instagram & Twitter - @insideozpodcast, and now on Mastodon - @email@example.com Email The Show – firstname.lastname@example.org #InsideOz Friends of Firefighters - https://friendsoffirefighters.org/
Thank you to Kyle for commissioning this episode!I can't believe this book is already over, but I hope that I managed to do it some kind of justice. I like where things are going with the Blossom Gang, but I'm a little worried about Savo/Kinri now that he's out there in the world by himself. Where is he going to go? What's he going to do? And what the fuck is happening with Jia's drug drop?Thanks for listening, and I will see you soon with the start of Speaking Bones.
Dr. Molly Dushnicky brings her JIA and physician perspective to this week's episode on Take a Pain Check. In this episode, Dr. Molly discusses the story of her JIA diagnosis at the age of two with approximately 45+ impacted joints. She faced barriers of access to care in her hometown Thunder Bay in Northern Ontario as there was no pediatric rheumatologist then and even now. She talks about how she had to be flown down to The Hospital of SickKids in Toronto and CHEO in Ottawa to be treated. Dr. Molly is a fighter who did not let the disease stop her from being active. She is passionate about soccer, curling and rock climbing and learned different strategies to overcome her disability. Dr. Molly discusses her advocacy through the challenges as well as accommodations at each stage of her life with her diseases from elementary to high school, and from university to medical school. She also provides insight to her residency and fellowship programs. Lastly, Dr. Molly shares her path to her career in pediatric rheumatology and how her passion drew her to what she loves to do today. Take a Pain Check's Merchandise Design Fundraiser Event: https://www.eventbrite.com/e/take-a-p... Check out Dr. Molly Dushnicky's socials: Twitter: @MDushnicky Check out our socials: Website: https://www.takeapaincheck.com/Instagram: https://www.instagram.com/takeapainch... Twitter: https://twitter.com/takeapaincheck Tiktok: https://www.tiktok.com/@takeapaincheck Growing Pains, Copyright, 2018, Alessia Cara
PaperPlayer biorxiv neuroscience
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.01.03.522525v1?rss=1 Authors: Hu, X., Zhu, Q., Lou, T., Hu, Q., Niu, X., He, L., Huang, H., Xu, Y., Qiu, M., Shen, Y., Jia, J.-M., Tao, Y. Abstract: White matter abnormalities are an emerging feature of schizophrenia, yet the underlying pathophysiological mechanisms are largely unknown. Disruption of ErbB signaling that is essential for peripheral myelination has been genetically associated with schizophrenia and white matter lesions in schizophrenic patients. However, the roles of ErbB signaling in oligodendrocytes remain elusive. Here, we used a pan-ErbB inhibition strategy and demonstrated the synergistic functions of endogenous ErbB receptors in oligodendrocytes. Through analyses of the cellular, histological, biochemical, behavioral, and electrophysiological differences in mice with manipulation of ErbB activities in oligodendrocytes at different differentiation stages, we found that ErbB signaling regulates myelination and aerobic glycolysis in oligodendrocytes, and both functions are required for working memory. ErbB inhibition in oligodendrocytes at early differentiation stages induces hypomyelination by suppressing the differentiation of newly-formed oligodendrocytes. In contrast, ErbB inhibition in mature oligodendrocytes alters neither myelination nor oligodendrocyte numbers, but accelerates axonal conduction decline under energy stress. Mechanistically, mature oligodendrocytes with ErbB inhibition reduce the expression of lactate dehydrogenase A, failing to provide lactate to electrically active axons. Supplementation of L-lactate restores axonal conduction and working memory capacity that are suppressed by ErbB inhibition in mature oligodendrocytes. These findings reveal the indispensable roles of ErbB signaling in white matter integrity and function, and provide insights into the multifaceted contributions of white matter abnormalities to cognitive impairment. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Do you feel like there is never enough time in the day? Join today's discussion with guest Dr. Jia to hear more about how you can prioritize time for clinical medicine, research, and family. Then, if you are looking to finish charting faster so you can go home sooner for what matters most to you, please join me for a free masterclass 1/4 with 1 FREE CME credit available. Register for the webinar HERE! Find Dr. Jia on YouTube https://www.youtube.com/@PublishedMD [0:00] Finish Charting Faster webinar [1:44] Dr. Jia's journey to becoming a nephrologist and a researcher. [5:17] Switching your mindset from reactive to proactive. [8:52] Advice for those who want to be successful in research. [12:55] Treating your research like a clinic appointment. [19:01] Integrating interests and aptitudes into your writing. [23:10] Finding time to do research [26:28] Self-care tips [30:43] Dr. Jia's final advice
PaperPlayer biorxiv neuroscience
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.22.521565v1?rss=1 Authors: Bian, X., Zhu, J., Jia, X., Liang, W., Li, Z., Yu, S., Rao, Y. Abstract: It has never been easy to discover a new neurotransmitter, especially one in the central nervous system (CNS). We have been searching for new neurotransmitters for 12 years. We detected creatine (Cr) in synaptic vesicles (SVs), at a level lower than glutamate (Glu) and gamma-aminobutyric acid (GABA) but higher than acetylcholine (ACh) and 5-hydroxytryptamine (5-HT). SV Cr was reduced in mice lacking either arginine:glycine amidinotransferase (AGAT, a Cr synthetase) or SLC6A8, a Cr transporter with mutations among the most common causes of intellectual disability (ID) in men. Calcium-dependent release of Cr was detected after stimulation in brain slices. Cr release was reduced in SLC6A8 and AGAT mutants. Cr inhibited neocortical pyramidal neurons. SLC6A8 was necessary for Cr uptake into synaptosomes. Cr was found by us to be taken up into SVs in an ATP dependent manner. Thus, our biochemical, chemical, genetic and electrophysiological results suggest Cr as a neurotransmitter, illustrate a novel approach to discover neurotransmitters and provide a new basis for ID pathogenesis. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
PaperPlayer biorxiv neuroscience
Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.22.521541v1?rss=1 Authors: Weis, M. A., Papadopoulos, S., Hansel, L., Lueddecke, T., Celii, B., Fahey, P. G., Bae, J. A., Bodor, A. L., Brittain, D., Buchanan, J., Bumbarger, D. J., Castro, M. A., Cobos, E., Collman, F., da Costa, N. M., Dorkenwald, S., Elabbady, L., Froudarakis, E., Halageri, A., Jia, Z., Jordan, C., Kapner, D., Kemnitz, N., Kinn, S., Lee, K., Li, K., Lu, R., Macrina, T., Mahalingam, G., Mitchell, E., Mondal, S. S., Mu, S., Nehoran, B., Patel, S., Pitkow, X., Popovych, S., Reid, R. C., Schneider-Mizell, C. M., Seung, H. S., Silversmith, W., Sinz, F. H., Takeno, M., Torres, R., Turner, N. L., Wong, W., Abstract: Neurons in the neocortex exhibit astonishing morphological diversity which is critical for properly wiring neural circuits and giving neurons their functional properties. The extent to which the morphological diversity of excitatory neurons forms a continuum or is built from distinct clusters of cell types remains an open question. Here we took a data-driven approach using graph-based machine learning methods to obtain a low-dimensional morphological "bar code" describing more than 30,000 excitatory neurons in mouse visual areas V1, AL and RL that were reconstructed from a millimeter scale serial-section electron microscopy volume. We found a set of principles that captured the morphological diversity of the dendrites of excitatory neurons. First, their morphologies varied with respect to three major axes: soma depth, total apical and basal skeletal length. Second, neurons in layer 2/3 showed a strong trend of a decreasing width of their dendritic arbor and a smaller tuft with increasing cortical depth. Third, in layer 4, atufted neurons were primarily located in the primary visual cortex, while tufted neurons were more abundant in higher visual areas. Fourth, we discovered layer 4 neurons in V1 on the border to layer 5 which showed a tendency towards avoiding deeper layers with their dendrites. In summary, excitatory neurons exhibited a substantial degree of dendritic morphological variation, both within and across cortical layers, but this variation mostly formed a continuum, with only a few notable exceptions in deeper layers. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC
Thank you to Kyle for commissioning this episode! In these chapters we get to see how Jia is taking some of the information being sent her way about the pirate problem going on around Unredeemed Dara. But mostly what we get is more of the competition between the Splendid Urn and the Treasure Chest, and I'm starting to get frustrated with our side for their lack of creativity in dealing with this clown.Thank you all so much for listening, and I will see you soon with a new episode!
Rheuma nachgefragt - Der Podcast aus der Praxis für die Praxis
Erwachsenwerden mit einer chronischen Erkrankung wie der RA birgt viele Herausforderungen, die im Rahmen einer gut gelungen Transition abgefedert werden können. Wie Transition in der Kinder- und Erwachsenenrheumatologie strukturiert werden kann, welche Empfehlungen es derzeit gibt und welche Konzepte sich in der praktischen Umsetzung bewährt haben – darüber sprechen Dr. Rebecca Hasseli und ihre beiden Gäste, die Rheumatologin Dr. Susanne Schalm und die Kinderrheumatologin Dr. Christiane Reiser.
In this episode, Chase, Sam, and JIA breakdown the Cavs Week 6 slate, debut a new segment "Drs R Us", and look ahead to the Week 7 slate of games. Sponsors: DrafKings Sportsbook Promo Code: P3CAVS Dkng.co/oh Produced by: Chase Smith The Press Play Podcast Network Follow us on Twitter: @cavsonthebreak / @pressplaypods For Sponsorship plans and more information, please email: email@example.com To listen to all our shows and learn more about our network, please visit www.pressplaypodcasts.com
Jacksonville's Morning News Interviews
Jessica reports on the increasing crowds and busy travel services at JIA, where they are expecting 10,000+ passengers per day over the holiday weekend.
This month on Episode 42 of Discover CircRes, host Cynthia St. Hilaire highlights four original research articles featured in the October 28 and November 11th issues of Circulation Research. This episode also features an interview with Dr Miguel Lopez-Ramirez and undergraduate student Bliss Nelson from University of California San Diego about their study, Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformations. Article highlights: Jia, et al. Prohibitin2 Maintains VSMC Contractile Phenotype Rammah, et al. PPARg and Non-Canonical NOTCH Signaling in the OFT Wang, et al. Histone Lactylation in Myocardial Infarction Katsuki, et al. PCSK9 Promotes Vein Graft Lesion Development Cindy St. Hilaire: Hi, and welcome to Discover CircRes, the podcast of the American Heart Association's Journal, Circulation Research. I'm your host, Dr Cindy St. Hilaire from the Vascular Medicine Institute at the University of Pittsburgh, and today, I'm going to be highlighting articles from our October 28th and our November 11th issues of Circ Res. I'm also going to have a chat with Dr Miguel Lopez-Ramirez and undergraduate student Bliss Nelson, about their study, Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformations. But, before I get into the interviews, here are a few article highlights. Cindy St. Hilaire: The first article is from our October 28th issue, and the title is, PHB2 Maintains the Contractile Phenotype of Smooth Muscle Cells by Counteracting PKM Splicing. The corresponding author is Wei Kong, and the first authors are Yiting Jia and Chengfeng Mao, and they are all from Peking University. Insults to blood vessels, whether in the form of atherosclerosis, physical injury, or inflammation, can trigger vascular smooth muscle cells to transition from a contractile state to a proliferative and migratory one. Accompanying this conversion is a switch in the cells' metabolism from the mitochondria to glycolysis. But what controls this switch? To investigate, this group compared the transcriptomes of contractile and proliferative smooth muscle cells. Among the differentially expressed genes, more than 1800 were reciprocally up and down regulated. Of those, six were associated with glucose metabolism, including one called Prohibitin-2, or PHB2, which the team showed localized to the artery wall. In cultured smooth muscle cells, suppression of PHB2 reduced expression of several contractile genes. While in rat arteries, injury caused a decrease in production of PHB2 itself, and of contractile markers. Furthermore, expression of PHB2 in proliferative smooth muscle cells could revert these cells to a contractile phenotype. Further experiments revealed PHB2 controlled the splicing of the metabolic enzyme to up-regulate the phenotypic switch. Regardless of mechanism, the results suggest that boosting PHB2 might be a way to reduce adverse smooth muscle cell overgrowth and conditions such as atherosclerosis and restenosis. Cindy St. Hilaire: The second article I'm going to highlight is also from our October 28th issue, and the first authors are Mayassa Rammah and Magali Theveniau-Ruissy. And the corresponding authors are Francesca Rochais and Robert Kelly. And they are all from Marseille University. Abnormal development of the heart's outflow track, which ultimately forms the bases of the aorta and the pulmonary artery, accounts for more than 30% of all human congenital heart defects. To gain a better understanding of outflow tract development, and thus the origins of such defects, this group investigated the role of transcription factors thought to be involved in specifying the superior outflow tract, or SOFT, which gives rise to the subaortic myocardium, and the inferior outflow tract, which gives rise to the subpulmonary myocardium. Transcription factor S1 is over-expressed in superior outflow tract cells and the transcription factors, TBX1 and PPAR gamma, are expressed in inferior outflow tract cells. And now this group has shown that TBX1 drives PPAR gamma expression in the inferior outflow tract, while Hess-1 surpasses PPAR gamma expression in the superior outflow tract. Indeed, in mouse embryos lacking TBX1, PPAR gamma expression was absent in the outflow tract. While in mouse embryos lacking Hess-1, PPAR gamma expression was increased and PPAR gamma positive cells were more widespread in the outflow tract. The team also identified that signaling kinase DLK is an upstream activator of Hess-1 and a suppressor of PPAR gamma. In further detailing the molecular interplay regulating outflow tract patterning, the work will shed light on congenital heart disease etiologies, and inform potential interventions for future therapies. Cindy St. Hilaire: The third article I want to highlight is from our November 11th issue of Circulation Research, and the title is Histone Lactylation Boosts Reparative Gene Activation Post Myocardial Infarction. The first author is Jinjin Wang and the corresponding author is Maomao Zhang, and they're from Harbin Medical University. Lactylation of histones is a recently discovered epigenetic modification that regulates gene expression in a variety of biological processes. In inflammation, for example, a significant increase in histone lactylation is responsible for switching on reparative genes and macrophages when pro-inflammatory processes give way to pro-resolvin ones. The role of histone lactylation in inflammation resolution has been shown in a variety of pathologies, but has not been examined in myocardial infarction. Wang and colleagues have now done just that. They isolated monocytes from the bone marrow and the circulation of mice at various time points after induced myocardial infarctions, and examined the cells' gene expression patterns. Within a day of myocardial infarction, monocytes from both bone marrow and the blood had begun upregulating genes involved in inflammation resolution. And, concordant with this, histone lactylation was dramatically increased in the cells, specifically at genes involved in repair processes. The team went on to show that injection of sodium lactate into mice boosted monocyte histone lactylation and improved heart function after myocardial infarction, findings that suggest further studies of lactylation's pro-resolving benefits are warranted. Cindy St. Hilaire: The last article I want to highlight is titled, PCSK9 Promotes Macrophage Activation via LDL Receptor Independent Mechanisms. The first authors are Shunsuke Katsuki and Prabhash Kumar Jha, and the corresponding author is Masanori Aikawa, and they are from Brigham and Women's Hospital in Harvard. Statins are the go-to drug for lowering cholesterol in atherosclerosis patients. But the more recently approved PCSK9 inhibitors also lower cholesterol and can be used to augment or replace statins in patients where these drugs are insufficient. PCSK9 is an enzyme that circulates in the blood and destroys the LDL receptor, thereby impeding the removal of bad cholesterol. The enzyme also appears to promote inflammation, thus potentially contributing to atherosclerosis in two ways. This group now confirms that PCSK9 does indeed promote pro-inflammatory macrophage activation and lesion development, and does so independent of its actions on the LDL receptor. The team assessed PCSK9-induced lesions in animals with saphenous vein grafts, which are commonly used in bypass surgery but are prone to lesion regrowth. They found that LDL receptor lacking graft containing mice had greater graft macrophage accumulation and lesion development when PCSK9 activity was boosted than when it was not. The animal's macrophages also had higher levels of the pro-inflammatory factor expression. Together, this work shows that PCSK9 inhibitors provide a double punch against atherosclerosis and might be effective drugs for preventing the all too common failure of saphenous vein grafts. Cindy St. Hilaire: So, today with me I have Dr Miguel Lopez-Ramirez and undergraduate student Bliss Nelson from the University of California in San Diego, and we're going to talk about their study, Neuroinflammation Plays a Critical Role in Cerebral Cavernous Malformation Disease, and this article is in our November 11th issue of Circulation Research. Thank you both so much for joining me today. Before we talk about the science, want to just maybe tell me a little bit about yourselves? Bliss Nelson: My name is Bliss Nelson. I'm a member of Miguel Lopez-Ramirez's lab here at UC San Diego at the School of Medicine. I'm an undergraduate student here at UC San Diego. I'm actually a transfer student. I went to a community college here in California and I got involved in research after I transferred. Cindy St. Hilaire: What's your major? Bliss Nelson: I'm a cognitive science major. Cindy St. Hilaire: Excellent. You might be the first undergrad on the podcast, which is exciting. Bliss Nelson: Wow. What an honor. Thank so much. Cindy St. Hilaire: And Miguel, how about you? Miguel Lopez-Ramirez: Yes, thank you. Well, first thank you very much for the opportunity to present our work through this media. It's very exciting for us. My name is Miguel Alejandro Lopez-Ramirez, and I'm an assistant professor in the Department of Medicine and Pharmacology here at UCSD. Cindy St. Hilaire: Wonderful. I loved your paper, because, well, first, I don't think I've talked about cerebral cavernous malformations. So what are CCMs, and why are they so bad? Bliss Nelson: Cerebral cavernous malformations, or CCMs for short, are common neurovascular lesions caused by a loss of function mutation in one of three genes. These genes are KRIT1, or CCM1, CCM2 and PDCD10, or CCM3, and generally regarded as an endothelial cell autonomous disease found in the central nervous system, so the brain and the spinal cord. The relevance of CCMs is that it affects about one in every 200 children and adults, and this causes a lifelong risk of chronic and acute hemorrhaging. CCMs can be quiescent or dynamic lesions. If they are dynamic, they can enlarge, regress, or behave progressively, producing repetitive hemorrhaging and exacerbations of the disease. Other side effects of the disease could be chronic bleedings, focal neurological deficits, headaches, epileptic seizures and, in some cases, death. There's no pharmacological treatment for CCMs. There's only one type of option some patients may have, which would be to have surgery to cut out the lesions. But of course this depends on where the lesion or lesions are in the central nervous system, if that's even an option. So sometimes there's no option these patients have, there's no treatment, which is what propels our lab to towards finding a pharmacological treatment or uncovering some of the mechanisms behind that. Cindy St. Hilaire: Do people who have CCM know that they have them or sometimes it not detected? And when it is detected, what are the symptoms? Bliss Nelson: Sometimes patients who have them may not show any symptoms either ever in their lifetime or until a certain point, so really the only way to find out if you were to have them is if you went to go get a brain scan, if you went to go see a doctor, or if you started having symptoms. But also, one of the issues with CCMs is that they're very hard to diagnose, and in the medical community there's a lack of knowledge for CCMs, so sometimes you may not get directed to the right specialist in time, or even ever, and be diagnosed. Miguel Lopez-Ramirez: I will just add a little bit. It is fabulous, what you're doing. I think this is very, very good. But yes, that's why they're considered rare disease, because it's not obvious disease, so sometimes most of the patient, they go asymptomatic even when they have one lesions, but there's still no answers of why patients that are asymptomatics can become symptomatics. And there is a lot in neuro study, this study that we will start mentioning a little bit more in detail. We try to explain these transitions from silent or, quiescent, lesion, into a more active lesion that gives the disability to the patient. Some of the symptoms, it can start even with headaches, or, in some cases, they have more neurological deficits that could be like weakness in the arms or loss of vision. In many cases also problems with the speech or balance. So it depends where the lesion is present, in the brain or in the spinal cord, the symptoms that the patient will experience. And some of the most, I will say, severe symptoms is the hemorrhagic stroke and the vascular thrombosis and seizure that the patients can present. Those would be the most significant symptoms that the patient will experience. Cindy St. Hilaire: What have been some limitations in the study of CCMs? What have been limitations in trying to figure out what's going on here? Bliss Nelson: The limitations to the disease is that, well, one, the propensity for lesions, or the disease, to come about, isn't known, so a lot of the labs that work on it, just going down to the basic building blocks of what's even happening in the disease is a major problem, because until that's well established, it's really hard to go over to the pharmacological side of treating the disease or helping patients with the disease, without knowing what's going on at the molecular level. Cindy St. Hilaire: You just mentioned molecular level. Maybe let's take a step back. What's actually going on at the cellular level in CCMs? What are the major cell types that are not happy, that shift and become unhappy cells? Which are the key players? Bliss Nelson: That's a great question and a great part of this paper. So when we're talking about the neuroinflammation in the disease, our paper, we're reporting the interactions between the endothelium, the astrocytes, leukocytes, microglia and neutrophils, and we've actually coined this term as the CaLM interaction. Cindy St. Hilaire: Great name, by the way. Bliss Nelson: Thank you. All props to Miguel. And if you look at our paper, in figure seven we actually have a great graphic that's showing this interaction in play, showing the different components happening and the different cell types involved in the CaLM interaction that's happening within or around the CCM lesions. Cindy St. Hilaire: What does a astrocyte normally do? I think our podcast listening base is definitely well versed in probably endothelial and smooth muscle cell and pericyte, but not many of us, not going to lie, including me, really know what a astrocyte does. So what does that cell do and why do we care about its interaction with the endothelium? Miguel Lopez-Ramirez: Well, the astrocytes play a very important role. Actually, there are more astrocytes than any other cells in the central nervous system, so that can tell you how important they are. Obviously play a very important role maintaining the neurological synapses, maintaining also the hemostasis of the central nervous system by supporting not only the neurons during the neural communication, but also by supporting the blood vessels of the brain. All this is telling us that also another important role is the inflammation, or the response to damage. So in this case, what also this study proposed, is that new signature for these reactive astrocytes during cerebral malformation disease. So understanding better how the vasculature with malformations can activate the astrocytes, and how the astrocytes can contribute back to these developing of malformations. It will teach us a lot of how new therapeutic targets can be implemented for the disease. This is part of this work, and now we extend it to see how it can also contribute to the communication with immune cells as Bliss already mentioned. Cindy St. Hilaire: Is it a fair analogy to say that a astrocyte is more similar to a pericyte in the periphery? Is that accurate? Miguel Lopez-Ramirez: No, actually there are pericytes in the central nervous system as well. They have different roles. The pericyte is still a neuron cell that give the shape, plays a role in the contractility and maintains the integrity of the vessels, while the astrocyte is more like part of the immune system, but also part of the supporting of growth factors or maintaining if something leaks out of the vasculature to be able to capture that. Cindy St. Hilaire: You used a handful of really interesting mouse models to conduct this study. Can you tell us a little bit about, I guess, the base model for CCM and then some of the unique tools that you used to study the cells specifically? Bliss Nelson: Yeah, of course. I do a lot of the animal work in the lab. I'd love to tell you about the mouse model. So to this study we use the animal model with CCM3 mutation. We use this one because it is the most aggressive form of CCM and it really gives us a wide range of options to study the disease super intricately. We use tamoxifen-regulated Cre recombinase under the control of brain endothelial specific promoter, driving the silencing of the gene CCM3, which we call the PDCD10 betco animal, as you can see in our manuscript. To this, the animal without the Cre system, that does not develop any lesions, that we use as a control, we call the PDCD10 plox. And these animals are injected with the tamoxifen postnatally day one, and then for brain collection to investigate, wcollected at different stages. So we do P15, which we call the acute stage, P50, which we term the progressive stage, and then P80, which is the chronocytes stage. And after enough brain collections, we use them for histology, gene expression, RNA analysis, flow cytometry, and different imaging to help us further look into CCMs. Cindy St. Hilaire: How similar is a murine CCM to a human CCM? Is there really good overlap or are there some differences? Miguel Lopez-Ramirez: Yes. So, actually, that's a very good question, and that's part of the work that we are doing. This model definitely has advantages in which the lesions of the vascular formations are in an adult and juvenile animals, which represent an advantage for the field in which now we will be able to test pharmacological therapies in a more meaningful, way where we can test different doses, different, again, approaches. But definitely, I mean, I think I cannot say that it's only one perfect model for to mimic the human disease. It's the complementary of multiple models that give us certain advantages in another, so the integration of this knowledge is what will help us to understand better the disease. Cindy St. Hilaire: That's great. I now want to hear a little bit about your findings, because they're really cool. So you took two approaches to study this, and the first was looking at the astrocytes and how they become these, what you're calling reactive astrocytes, and then you look specifically at the brain endothelium. So could you maybe just summarize those two big findings for us? Miguel Lopez-Ramirez: Yeah, so, basically by doing these studies we use trangenic animal in this case that they give us the visibility to obtain the transcripts in the astrocytes. And basically this is very important because we don't need to isolate the cells, we don't need to manipulate anything, we just took all the ribosomes that were basically capturing the mRNAs and we profile those RNAs that are specifically expressed in the astrocytes. By doing this, we actually went into looking at in depth the transcripts that were altered in the animals that developed the disease, in this case the cerebral cavernous malformation disease, and what we look at is multiple genes that were changing. Many of them were already described in our previous work, which were associated with hypoxia and angiogenesis. But what we found in this work is that now there were a lot of genes associated with inflammation and coagulation actually, which were not identified before. What we notice is that now these astrocytes, during the initial phase of the vascular malformation, may play a more important role in angiogenesis or the degradation of the vessels. Later during the stage of the malformation, they play a more important role in the thrombosis, in the inflammation, and recruitment of leukocyte That was a great advantage in this work by using this approach and looking in detail, these astrocytes. Also, we identified there were very important signature in these astrocytes that we refer as a reactive astrocytes with neuroinflammatory properties. In the same animals, basically, not in the same animal, but in the same basically the experimental approach, we isolated brain vasculature. And by doing the same, we actually identified not only the astrocyte but also the endothelium was quite a different pattern that we were not seeing before. And this pattern was also associated with inflammation, hypoxia and coagulation pathways. That lead us to go into more detail of what was relevant in this vascular malformations. And one additional part that in the paper this is novel and very impactful, is that we identify inflammasome as a one important component, and particularly in those lesions that are multi-cavernous. Now we have two different approaches. One, we see this temporality in which the lesions forms different patterns in which the initial phase maybe is more aneugenic, but as they become more progressive in chronocytes, inflammation and hypoxy pathways are more relevant for the recruitment of the inflammatory cells and also the precipitation of immunothrombosis. But also what we notice is that inflammasome in endothelial and in the leukocytes may play an important role in the multi-cavernous formation, and that's something that we are looking in more detail, if therapeutics or also interventions in these pathways could ameliorate the transition of phases between single lesions into a more aggressive lesions. Cindy St. Hilaire: That's kind of one of the follow up questions I was thinking about too is, from looking at the data that you have, obviously to get a CCM, there's a physical issue in the vessel, right? It's not formed properly. Does that form influence the activation of the astrocyte, and then the astrocytes, I guess, secrete inflammatory factors, target more inflammation in the vessel? Or is there something coming from the CCM initially that's then activating the astrocyte? It's kind of a chicken and the egg question, but do you have a sense of secondary to the malformation, what is the initial trigger? Miguel Lopez-Ramirez: The malformations in our model, and this is important in our model, definitely start by producing changes in the brain endothelial. And as you mention it, these endothelium start secreting molecules that actually directly affect the neighboring cells. One of the first neighboring cells that at least we have identified to be affected is the astrocytes, but clearly could be also pericytes or other cells that are in the neurovascular unit or form part of the neurovascular unit. But what we have seen now is that this interaction gets extended into more robust interactions that what you were referring as the CaLM interactions. Definitely I think during the vascular malformations maybe is the discommunication that we identify already few of those very strong iteration that is part of the follow up manuscript that we have. But also it could be the blood brain barrier breakdown and other changes in the endothelium could also trigger the activation of the astrocytes and brain cells. Cindy St. Hilaire: What does your data suggest about potential future therapies of CCM? I know you have a really intriguing statement or data that showed targeting NF-kappa B isn't likely going to be a good therapeutic strategy. So maybe tell us just a little bit about that, but also, what does that imply, perhaps, of what a therapeutic strategy could be? Bliss Nelson: Originally we did think that the inhibition of NF-kappa B would cause an improvement potentially downstream of the CCMs. And unexpectedly, to our surprise, the partial or total loss of the brain endothelial NF-kappa B activity in the chronic model of the mice, it didn't prevent or cause any improvement in the lesion genesis or neuroinflammation, but instead it resulted in a trend to increase the number of lesions and immunothrombosis, suggesting that the inhibition of it is actually worsening the disease and shouldn't be used as a target for therapeutical approaches. Miguel Lopez-Ramirez: Yes, particularly that's also part of the work that we have ongoing in which NF-kappa B may also play a role in preventing the further increase of inflammation. So that is something that it can also be very important. And this is very particular for certain cell types. It's very little known what the NF-kappa B actually is doing in the brain endothelial during malformations or inflammation per se. So now it's telling us that this is something that we have to consider for the future. Also, our future therapeutics of what we propose are two main therapeutic targets. One is the harmful hypoxia pathway, which involves activation, again, of the population pathway inflammation, but also the inflammasomes. So these two venues are part of our ongoing work in trying to see if we have a way to target with a more safe and basically efficient way this inflammation. However, knowing the mechanisms of how these neuroinflammation take place is what is the key for understanding the disease. And maybe even that inflammatory and inflammatory compounds may not be the direct therapeutic approach, but by understanding these mechanisms, we may come with new approaches that will help for safe and effective therapies. Cindy St. Hilaire: What was the most challenging part of this study? I'm going to guess it has something to do with the mice, but in terms of collecting the data or figure out what's going on, what was the most challenging? Bliss Nelson: To this, I'd like to say that I think our team is very strong. We work very well together, so I think even the most challenging part of completing this paper wasn't so challenging because we have a really strong support system among ourselves, with Miguel as a great mentor. And then there's also two postdocs in the lab who are also first authors that contributed a lot to it. Cindy St. Hilaire: Great. Well, I just want to commend both of you on an amazing, beautiful story. I loved a lot of the imaging in it, really well done, very technically challenging, I think, pulling out these specific sets of cells and investigating what's happening in them. Really well done study. And Bliss, as an undergraduate student, quite an impressive amount of work. And I congratulate both you and your team on such a wonderful story. Bliss Nelson: Thank you very much. Miguel Lopez-Ramirez: Thank you for Bliss and also Elios and Edo and Katrine, who all contributed enormously to the completion of this project. Cindy St. Hilaire: It always takes a team. Miguel Lopez-Ramirez: Yes. Cindy St. Hilaire: Great. Well, thank you so much, and I can't wait to see what's next for this story. Cindy St. Hilaire: That's it for the highlights from October 28th and November 11th issues of Circulation Research. Thank you so much for listening. Please check out the Circ Res Facebook page and follow us on Twitter and Instagram with the handle @circres and #discovercircres. Thank you to our guests, Dr Miguel Lopez-Ramirez and Bliss Nelson. This podcast is produced by Ashara Retniyaka, edited by Melissa Stoner, and supported by the editorial team of Circulation Research. Some of the copy text for our highlighted articles is provided by Ruth Williams. I'm your host, Dr Cindy St. Hilaire, and this is Discover CircRes, you're on the go source for the most exciting discoveries in basic cardiovascular research. This program is copyright of the American Heart Association 2022. The opinions expressed by speakers in this podcast are their own and not necessarily those of the editors or of the American Heart Association. For more information, please visit ahagenerals.org.
Comorbidities in Axial Spondyloarthritis Dr. Antoni Chan discusses Abstract 1609 at ACR22 Convergence. Diffuse alveolar hemorrhage in antiphospholipid syndrome Dr. Eric Dein discusses Abstract 0675 at ACR22 Convergence. Abstract 0675: Clinical Characteristics and Factors Associated with Relapse and Mortality in Diffuse Alveolar Hemorrhage Among Patients with Antiphospholipid Syndrome: A Multi-Center Retrospective Cohort Eosinophilia in systemic JIA patients after exposure to biologics Dr. Bella Mehta discusses Abstract 0872 at ACR22 Convergence. Abstract 0872: Incidence, Risk Factors, and Outcomes of Eosinophilia on IL-1 and IL-6 Inhibitors in Systemic and Non-Systemic Juvenile Idiopathic Arthritis Gender differences in Axial Spondyloarthritis Dr. Antoni Chan covered abstracts 0497 and 1614 at ACR22 Convergence in Philadelphia, PA. Inadequate Dosing of Hydroxychloroquine Leads to Hospitalizations in SLE Dr. Sheila Reyes discusses abstract 1654 at ACR22 Convergence. Abstract 1654: Hydroxychloroquine Dosing Less Than 5 Mg/kg/day Leads to Increased Hospitalizations for Systemic Lupus Erythematosus Flares Oligoarticular PsA: FOREMOST Study Dr. Peter Nash discusses abstract 1018 at ACR22 Convergence. Abstract 1018: Characterization of Joint Distribution and Disease Burden in Patients with Early Oligoarticular Psoriatic Arthritis: Results from the Ongoing FOREMOST Study Sensor-engineered glove evaluates hand function in RA Dr. David Liew discusses abstract 0904 at ACR22 Convergence. Abstract 0904: Testing the Hand Function with a Sensor-engineered Glove in Patients with Rheumatoid Arthritis
Good News for Cities〜都市に関する炉辺談話
今回は、京都を拠点に活動する木村松本建築設計事務所のスタジオを杉田が訪問。1924年竣工の「本野精吾邸」をリノベーションした素敵な事務所で、住宅を中心に新築やリノベーションを問わず幅広く建築設計を手がけるお二人が大切にしている考え方、デザインのプロセスなどについてお話を聞きました。細長〜い住居兼店舗バ・ヒュッテ、北山ホールセンター、京都・梅小路公園に設置したコンポスト、メンテナンスの場としての住宅などなど。建築好きにはたまらないトピックがぎっしりです！ ◉ゲストプロフィール 木村吉成／建築家：1973年和歌山県生まれ。大阪芸術大学卒業後、狩野忠正建築研究所を経て、2003年に木村松本建築設計事務所を共同設立。現在、大阪芸術大学准教授。 松本尚子／建築家：1975年京都府生まれ。大阪芸術大学卒業後、2003年に木村松本建築設計事務所を共同設立。現在、京都芸術大学専任講師、大阪公立大学非常勤講師。 主な受賞に、第33回JIA新人賞、第4回藤井厚二賞、第33回吉岡賞、第12回JIA関西建築家新人賞、第3回JIA東海住宅建築賞など。 木村松本建築設計事務所：http://kmrmtmt.com/ --- Send in a voice message: https://anchor.fm/good-news-for-cities/message
John and JIA recap the Cavaliers' 8-game win streak, what worked and didn't work in Los Angeles,the guys react to LeBron James' comments about the up-start Cavs, what is sustainable and not sustainable for Cleveland's production, and much more! Sponsors: Aligned Health Centers http://www.alignedhealthcenters.com 440.385.7357 DrafKings Sportsbook Promo Code: P3CAVS Dkng.co/oh Produced by: John Sabol The Press Play Podcast Network Follow us on Twitter: @cavsonthebreak / @pressplaypods For Sponsorship plans and more information, please email: firstname.lastname@example.org To listen to all our shows and learn more about our network, please visit www.pressplaypodcasts.com
Good News for Cities〜都市に関する炉辺談話
滋賀県に拠点を置くStudio on_siteの建築家・大野宏さんが、杉田の自宅である京都に遊びにきてくれました。Studio on_siteは、土地の自然がもつ材料、土地の人がもつ知恵や技術を再編集し、地球の循環の中で家具や建築をつくるスタジオです。フィリピン、インド、アフリカ各国などをはじめとした発展途上国での建築プロジェクトの話や、バナキュラーな技術やその土地ならではの素材、見知らぬ場所でのリサーチの手法などをお話しています。 ◉ゲストプロフィール 大野宏 / Hiroshi Ohno 1992年生まれ。特定非営利法人Studio on_site代表。滋賀県立大学環境科学研究科環境計画学 博士後期課程に在籍。土地に根付く素材や職人の持つ技法を活かし、その地域特有の建築を模索し、現地の生活の背景を持つ建築を作る。大学で研究を行うと同時に、日本・フィリピン・インド等で建築の設計活動を行っている。 2015年 日本建築学会大会デザイン発表会 審査員賞 2015年 JIA全国卒業設計審査会 2015年 福岡Design Review 優秀賞 2014年 熱発コンペティション 審査員賞 2014年 NEXTA2014 審査員賞 HP http://studioon.site IG https://www.instagram.com/studioon_site/ --- Send in a voice message: https://anchor.fm/good-news-for-cities/message
Sam, Chase, and JIA recap the blazzing 5-1 start for the Cavs and look ahead to Week 3's Slate. Sponsors: Aligned Health Centers http://www.alignedhealthcenters.com 440.385.7357 DrafKings Sportsbook Promo Code: P3CAVS Dkng.co/oh Produced by: Chase Smith The Press Play Podcast Network Follow us on Twitter: @cavsonthebreak / @pressplaypods For Sponsorship plans and more information, please email: email@example.com To listen to all our shows and learn more about our network, please visit www.pressplaypodcasts.com
Teacher Talk with Chrissy Nichols
Rejection Therapy? What is that? In this episode, I talk about my own journey to fall more in love with my own sense of rejection and fear as I apply the tools I am learning from actively seeking rejection in my own life and in my business. My inspiration comes from Jason Comely and Jia Jiang who shared his own powerful journey with rejection in a TedX that you can watch here: https://www.youtube.com/watch?v=-vZXgApsPCQ. Impressed by Jia, in this episode, I share how I have started to create a closer relationship with rejection by simply asking a question. I am able to collect a no and it doesn't kill me. The fear of what people will think, the fear of a no, the fear of disapproval: it no longer hurts me as it may once have. But these things don't have to be big asks for us to experience big change. Asking for what you will change your life. So where can you ask for what you want? Where can you feel nervous about a rejection but ask it any way? Enjoy this episode about fear and rejection. Resources: Follow Chrissy on Instagram @chrissyconcept. Sign up for a FREE 30 minute coaching call. More About Teacher Talk with Chrissy Nichols: Teacher Talk is the podcast for educators like you who are on the brink of burnout, or are already there. It's your guide to feeling better about being at school and being in your life. Your host, Chrissy Nichols, is a life coach for teachers. In her weekly episodes, she will give you quick tools, tips, and brain hacks to understand that there is absolutely nothing wrong with you. It's time to find the joy in teaching again and get back to feeling like the best version of yourself.
Chase, Sam, and JIA recap a strong Week 1 Slate for the Cavs and look ahead to Week 2. They introduce a new segment at the top of the show, TRIPLE THREAT. Sponsors: Aligned Health Centers http://www.alignedhealthcenters.com 440.385.7357 DrafKings Sportsbook Promo Code: P3CAVS Dkng.co/oh Produced by: Chase Smith The Press Play Podcast Network Follow us on Twitter: @cavsonthebreak / @pressplaypods For Sponsorship plans and more information, please email: firstname.lastname@example.org To listen to all our shows and learn more about our network, please visit www.pressplaypodcasts.com
Chase, Sam, and JIA recap a strong Week 1 Slate for the Cavs and look ahead to Week 2. They introduce a new segment at the top of the show, TRIPLE THREAT. Sponsors: Aligned Health Centers http://www.alignedhealthcenters.com 440.385.7357 DrafKings Sportsbook Promo Code: P3CAVS Dkng.co/oh Produced by: Chase Smith The Press Play Podcast Network Follow us on Twitter: @cavsonthebreak / @pressplaypods For Sponsorship plans and more information, please email: email@example.com To listen to all our shows and learn more about our network, please visit www.pressplaypodcasts.com
Wellness by Designs - Practitioner Podcast
Today, we are joined by Vanessa Vanderhoek, a functional nutritionist with a professional and personal interest in juvenile idiopathic arthritis, JIA. Today we discuss a functional approach to treating JIA.In this episode, Vanessa discusses:A typical treatment journey for children with JIAThe latest scientific updates for treating JIAThe gut connection, testing and assessment Nutritional treatment Supporting JIA kids and their familiesAbout VanessaVanessa's journey to becoming a Functional Nutritionist was by accident. Her daughter was diagnosed with an autoimmune disease (juvenile idiopathic arthritis, JIA) at the age of 2. Vanesa delved in to study the science about food and nutrition, and the impact it has on the systems in the body. This led her to some pretty incredible results. Her daughter regained her health and continues to be in remission. And also through this journey, Vanessa and her husband also uplevelled their health and wellbeing for the better. Vanessa continues to research the power of nutrition, gut health, and the life-changing positive impact it has for children with JIA. She understands making nutrition and lifestyle changes can be hard for families, and is known for her empathetic and compassionate approach. Vanessa is the founder of The Parent's Roadmap: A Functional Nutrition Approach to JIA. To learn more and book a free Discovery. callConnect with Vanessa: Website: The Healthy Gut NutritionistShownotes and references available on your local Designs for health website www.designsforhealth.com.au Register as a Designs for Health Practitioner and discover quality practitioner-only supplements at www.designsforhealth.com.auDISCLAIMER: The Information provided in the Wellness by Designs podcast is for educational purposes only; the information presented is not intended to be used as medical advice; please seek the advice of a qualified healthcare professional if what you have heard here today raises questions or concerns relating to your health
Thank you to Kyle for commissioning this episode!In these chapters, there's far more devastation within Thera's community than I wax expecting. In fact, saying "within the community" is suggesting there's still a community at all after what happens, and that's barely true. Meanwhile we get a really fascinating conversation between Jia and Zomi, and I can't help but be impressed with Jia despite the fact that she's clearly planning on doing something monstrous. Thanks for listening, and I will see you soon with a new episode!
INTRODUCTION: Shawn Murphy is the host of the Above The Bar podcast and a fellow military veteran. Join us as we discuss military issues, what it's like being a latchkey kid, growing up with a drug dealing dad and my new psychedelic journey!!! INCLUDED IN THIS EPISODE (But not limited to): · Military Matters – Burn Pits & Legislation· Cannabis In Massachusetts · My New Drug Journey - #Psychedelics · Why Trauma Is The Real Gateway Drug· Having A Drug Dealing Dad· Relationships/Divorce In The Military· Can We Be Addicted To Marriage?· Latchkey Kid Issues· Military Recruiter Tea· Gay Marine Stories!!! CONNECT WITH SHAWN: LinkedIn: https://www.linkedin.com/in/theabovethebarpodcast/YouTube: https://bit.ly/3QCmg05Facebook: https://www.facebook.com/theabovethebarpodcast/Instagram: https://bit.ly/3LglTr1TikTok: https://www.tiktok.com/@theabovethebarpodcastTwitter: https://bit.ly/3qzq5ssTwitch: https://www.twitch.tv/theabovethebarpodcastPodBean: https://theabovethebarpodcast.podbean.com CONNECT WITH DE'VANNON: Website: https://www.SexDrugsAndJesus.comWebsite: https://www.DownUnderApparel.comYouTube: https://bit.ly/3daTqCMFacebook: https://www.facebook.com/SexDrugsAndJesus/Instagram: https://www.instagram.com/sexdrugsandjesuspodcast/Twitter: https://twitter.com/TabooTopixLinkedIn: https://www.linkedin.com/in/devannonPinterest: https://www.pinterest.es/SexDrugsAndJesus/_saved/Email: DeVannon@SexDrugsAndJesus.com DE'VANNON'S RECOMMENDATIONS: · Pray Away Documentary (NETFLIX)o https://www.netflix.com/title/81040370o TRAILER: https://www.youtube.com/watch?v=tk_CqGVfxEs · OverviewBible (Jeffrey Kranz)o https://overviewbible.como https://www.youtube.com/c/OverviewBible · Hillsong: A Megachurch Exposed (Documentary)o https://press.discoveryplus.com/lifestyle/discovery-announces-key-participants-featured-in-upcoming-expose-of-the-hillsong-church-controversy-hillsong-a-megachurch-exposed/ · Leaving Hillsong Podcast With Tanya Levino https://leavinghillsong.podbean.com · Upwork: https://www.upwork.com· FreeUp: https://freeup.net VETERAN'S SERVICE ORGANIZATIONS · Disabled American Veterans (DAV): https://www.dav.org· American Legion: https://www.legion.org· What The World Needs Now (Dionne Warwick): https://www.youtube.com/watch?v=FfHAs9cdTqg INTERESTED IN PODCASTING OR BEING A GUEST?: · PodMatch is awesome! This application streamlines the process of finding guests for your show and also helps you find shows to be a guest on. The PodMatch Community is a part of this and that is where you can ask questions and get help from an entire network of people so that you save both money and time on your podcasting journey.https://podmatch.com/signup/devannon TRANSCRIPT: [00:00:00]You're listening to the sex drugs and Jesus podcast, where we discuss whatever the fuck we want to! And yes, we can put sex and drugs and Jesus all in the same bed and still be all right at the end of the day. My name is De'Vannon and I'll be interviewing guests from every corner of this world as we dig into topics that are too risqué for the morning show, as we strive to help you understand what's really going on in your life.There is nothing off the table and we've got a lot to talk about. So let's dive right into this episode.De'Vannon: Shawn Murphy is the host of the above the bar podcast, and a fellow military veteran of mine. Join us today. As we discuss military issues, what it's like being a latchkey kid, what it's like growing up with a drug dealing data in my personal news psychedelic journey. Y'all they tuned listen close, and I hope you enjoy the fuck out of this episode.God bless [00:01:00] you.Hello everyone. And welcome to the sex drugs in Jesus podcast. Yes, he is up there. He is looking over me. He's looking over Sean. He is looking over all of you. Beautiful fuckers. And yes, Jesus told me to call you all fuckers today because he is super open minded and super and super loving and words like that.Simply don't offend him. Sean, how are you? Shawn: Wonderful there. Good, sir. How are you? De'Vannon: Fan fucking y'all Sean Murphy is the AU shit. The author is the host. Oh, bring us that book. I'm ready to say author, man, bring that book. It's Shawn: it's in the works. It's in the works. We gotta make it happen. He De'Vannon: is the host of the above the bar podcast where every week they belly up to the bar and talk about all kinds of shit.And I was on his show. And now we're doing the flip fuck thing that we often do [00:02:00] in the podcast industry. He did mean I'm gonna do him. You all this make me a bottom. Shawn: Does this make me a bottom, a De'Vannon: podcast bottom in this moment? Yes. And I prefer a nice dry fuck. I might spit on your whole little bit. Other than that I'll LA natural brow baby.Shawn: I'll try, I guess, you know, as having my own show, I'll try not to be too much of a power bottom. I guess. That's what that would make me right. If I have my own show and I'm on the other side, does that, what that makes me. De'Vannon: Let's abandon all these titles. Just do what the fuck says.Shawn: oh brother. It is good to see you, man. You're looking De'Vannon: good. You're looking gorgeous. I got my beard growing out. Cause my stylist is gonna turn in a weird ass color. As I approach 40 years old in December. I want to be sure that I get weirder and weirder as I get older and older. And and so yeah, y'all Sean, you know, and I love your beer too.We're compliment complimenting each other's you were before we got on the [00:03:00] broadcast, Sean is a military veteran. I'm a military veteran. And so show we're gonna be talking about his podcast, his military experience, and is gonna get dark is gonna get dim, but I will end it with a Ray of hope and light for our veterans out there.And so we need veterans, all of your motherfuckers out there. Couldn't run around. Doing the bullshit. You like to do fucking your brains out, doing all your drugs, you know, making all the money, raising all the children and everything. And I love all of those things, but without a military in place, crazy as dictators would come over here and snatch your shit from you in a minute, you know?And then the people who those crazy as dictators have sent into the country to spy and shed. And yeah, I mean, that's just the way the world works. We have spies in other countries, no reason for us to think that they don't have spies here. Right. But the military helps to keep all of that shit at ban from spiraling out of hand.So as two veterans, [00:04:00] we above all people have the right to comment on veterans' issues, more so than crazy as Republicans do. And anybody who dares to think that they're speaking on behalf of us, because usually I don't agree with what politicians say about veterans. And so, so we're gonna talk a lot about veterans in this episode.So I see the way you're nodding and then light in your eyes. So tell me what Tim was on your mind. Just let those thoughts out. Shawn: No, it, well, you know, it's funny when you bring that up, it, they suck on both sides of the fence. Yeah. They, they really do because you know, it's funny growing up in the timeframe that I grew up in the military, not I joined in 94.We were, it it's so funny. We were always told you vote Republican, that they they're gonna fund you. They're gonna give you money. They're gonna take care of you. Do you know who gave me my most pay raises in all my 20 years, who gave me the most pay raises De'Vannon: bill Shawn: Clinton, [00:05:00] bill Clinton in the Clinton administration.They're 50 50 in my book, cuz. Were the ones that realized a lot of guys were getting outta the service and taking better paying jobs than staying in because there was no money there in 94, I made less than a thousand dollars a month in the Marine Corps. Ooh. That was the DOD across the board. E one was less than a thousand dollars a month.And you still had taxes taken out of that. Yeah. Look at that. That's a sour face, like, and that's the facts, but I will also say on the flip side, he also created the bra base relocation closure act that closed down all those bases and shut down small towns that lived and thrived off those bases that existed.So I'm 50 50 on that guy, but it's funny. They both suck, you know, look at what just happened with the burn pit bill, like, and for, for those that don't know what the burn pit bill was, that's burning medical waste plastics, and anything else you could imagine and [00:06:00] service members having to do it without proper ventilation without respirators and getting sick.And these guys, the Republicans voted it down because they wanted to show the Democrats that they didn't like some other bill. And they were like, ha, ha look what we'll do. Like really like you did that. You bunch of SC holes. So that's my feelings on all of them. De'Vannon: Right. And so, so Senate Manor, majority leader, Chuck Schumer pulled like a Ropa dope on the Republicans and was able to get like a lot of the reconciliation infrastructure, climate change stuff passed through.And the Republicans felt tricked, you know, Biden and everything like that. I, I kind of felt tricked by it in a positive way because Democrats usually don't act like they have nuts and so I was like, wait, you actually. Back at the Republicans [00:07:00] one. And so, but they were real, but hurt over that shit and yeah, they did oh yeah.Cause it never happened. They're like the, the Republicans are like the bully who was used to getting their way. They're not used to anybody actually hitting them back. Or, and so the burn pit bill is something that Republicans kept pushing against why we don't know, but you know, and they were all pissy about it, but you know, it finally passed and everything like that.And so I, I just, since you mentioned bill, bill Clinton, BC, my homeboy, I Kansas bill. I love the fat art, Kansas bill. And there's a whole, like, what is it? A bill Clinton museum and shit. When I was in little rock or something. Well, Shawn: that's right. I forgot you did live in little rock. I, no, I didn't live De'Vannon: there.I just visited it, just friends. But there's like a whole museum in his honor. They love them. Some bill Clinton, they don't care how he got his Dick sucked and the Al office. And I, I commend him for playing the saxophone, smoking his weed. If he [00:08:00] did smoke weed, I just picture it with, he just didn't hell he didn't inhale getting his Dick sucked.I don't know what kind of marriage arrangement him and Hillary had. I commend her on keeping her shit classing and together, no matter what, I love me. Some bill Clinton, anybody who gonna get they knob swabbed in the oval office, which I would imagine every president has. Otherwise I fuck with you. Shawn: I mean, that's one of those weird ones where everybody was up in arms about it, but were you up in arms about Kennedy?Like, like let's, let's understand that the JFK. Was an old, was an old school pimp and he made that happen. Like let's not get that twisted like that. Don't he was there. I mean, so why do but he changed, you know, what, he changed an outlook of an entire generation towards those things. When he said I didn't have relations with that, with that woman.And everybody was like, see, do get in little head that [00:09:00] ain't relations. That ain't, that ain't nothing that ain't nothing. And it was like, yeah, go ahead and tell your old lady that see how that works out for you. De'Vannon: It wasn't me. mm-hmm what the camera say. And like the song, it wasn't me. Right? Shaggy. I think that was, he Shawn: was a Marine.Did you know he was a Marine? Nah. Yep. Shaggy was a, an artillery was in second battalion. Oh God can't think of what company, but he was, he was second battalion two 10. Two. Yeah. Second Italian 10th Marine regiment out of Jacksonville, North Carolina. He was an artillery Marine and I knew a guy.One of those knew a guy who knew a guy's situations, but knew somebody who knew him. And they said he used to go home every weekend to go do shows. Cuz that was, he wanted to have a music career, but he was an artillery Marine De'Vannon: that's dedication there. Now he's even that much more sex now that I know [00:10:00]he's a Marine I love it brother.So, so your show, the above the bar podcast. Why did you name the that? Shawn: Well, cuz all my equipment truly sits above my bar right now is you and I are talking all my equipment and is sitting above my bar. I have a bar in my home, but the other side to it is, is, is there's. I like double and undress the O the other side to it is the term keeping things above the bar, keeping things, real, keeping things legit.So I always enjoyed when I talked to people, hearing the real stories of their lives or their background, like you and I, when we talked, when you were on my show, you kept it real. There was, you know, there was real energy in that real advice, real things that had happened in your life. And you didn't sugarcoat 'em, you didn't weigh 'em down with, you know, blaming other people or blaming other.You were real about all of it. And that's what I love. So that's why it's the above the bar podcast. [00:11:00] All right. De'Vannon: Now, thank you for all those compliments and everything. I'm glad you appreciate the my direct tone. I'll say it like that. And so How long have you been doing Shawn: it? So we, we started this in June of last year.It was one of those situations where my, I had said many times I wanted to do it. I had been on some friends podcast that were very successful. We're on a network called the earplug podcast network. That's owned by a friend of mine, herb and been on his shows a bunch of times. And I kept saying I was gonna do it.I was gonna do it. My wife finally said on father's day, weekend of last year, she just turned around and she handed me all the equipment. And it was like, there you go. And it was actually might actually now think about it. It might have been father's day 20, 20 God time has flown. Cause we just finished [00:12:00] episode 1 36 or 1 37.Got another one tomorrow cuz today is Tuesday, right? Yeah. Today's Tuesday. So we got another one coming up, so just. Once it got going, it just kind of, it's had a life of its own. Hmm. De'Vannon: Well, I'm happy you found something that, that you love and oh my God, excuse me. I took my ass out in the backyard, my weed eater, call myself cutting fucking grass and shit like that because I just thought it was hideous. This is something I pay other people to do, particularly my parents this cause my, this is my parents doesn't mean that I'm gonna like have them work for free, you know, I still pay them, but I shouldn't do that.Cuz I had really sensitive allergies and I went out there and did it. I didn't put a mask on. So I've got the scratchy ass throat. It's like a whole thing. It's not the COVID I've never had COVID but I've been taking the test every day [00:13:00] just to be sure. And it's still negative. So it was just allergy. So hopefully I don't cough too fucking much.So who do you think your target audience is? So Shawn: I actually, do you know, what do you know about creating your audience avatar? Have you ever heard that term? De'Vannon: I think I've heard the term, but just tell us, Shawn: so, so I have a real good, good friend of mine, Jessica Gruber, she builds podcast or builds websites.And she has her own podcast also. And Jessica and I were talking and she said that to me, one day, she goes, who's your avatar? And I'm like, I, what? Like I'm thinking video game avatar or something like that. So she explained it to me and said, sent me some stuff, basically. It's. Kind of creating the image of what your target audience looks like and giving them a name that way when you're marketing yourself, you can actually say, well, would Steve, or would Jane listen to this [00:14:00] or that?So I've kind of figured it out that my target audience is probably late thirties at the youngest. I would say maybe mid up through unknown finished age, probably closer to mid forties. Not necessarily would they have a bachelor's degree, but they're educated in what they do. They're professionals, they like food, they like drink and they, like, they probably will be caught watching the history channel or some, or like documentaries or things of that nature they like to learn.Yeah, I would De'Vannon: imagine. And that's a beautiful avatar. I would imagine most people who bother to click on a podcast. Are trying to be enlightened on some level, I suppose, even an entertainment podcast and stuff like that. Even if it's finding out that, you know, ASRA Miller this Cod a felony for [00:15:00]being a little club to, you know, you know, you're still being enlightened.You're learning something you didn't know before. And I am not throwing shade at your Miller. They are very beautiful specimen of a human and baby. They can come and steal for me any day. I need, I need them to come steal my virginity all over again. That's what all over . That's what I need that beautiful, that beautiful thing to come and steal, baby.You didn't have to do all that. You could have come taken all that stress out right over here. so, and what do you, what are you drinking? Is that like a bourbon, a scar? Uh, So, Shawn: so I was drinking a little bit of so one of our former guests they have a. Distillery up here in the upstate New York area called new Scotland spirit.So I'm having a little bit there straight rye whiskey which is actually, I learned this from the, these guys, rye is a New York grain. So I didn't know that. So [00:16:00] all the times of hearing about rye whiskey, I learned from them. So they make what they call an empire rye. So it's mostly New York rye grain, and it's phenomenal.I love it. De'Vannon: Hmm. Well drink up. So as you were going over some of your target, I mean, you know, your kind of the breakdown of your show, I had to say, I agree. I feel like the information that you cover is very practical. Like some of the titles I wrote a few down like what is networking, how to build a website, how to start a music label.You know, it's like, you're trying to help people and to give them like steps and practical things that they can use. So I would not classify your podcast as an entertainment podcast. This is a very like lifestyle podcast. And it's like, you're trying to help people be better, like come up out of whatever their circumstance or situation is.It's like, you're trying to help them get knowledge and information that they, that might be out of their grasp. Other one it's. Thank you. And so now one is called cannabis. Oh, you're welcome sugar. Now one is called [00:17:00] cannabis and Massachusetts that I wanted to stop and kind of like meditate on this one here for a moment.These are some of my favorite titles after we get done with this Massachusetts meditation, I'm gonna ask you what your, what you feel like for you your most impactful episode was so you can just chew on that in the background. So this stood out to me because I'm on a new drug journey. And so when you did this episode on the cannabis of Massachusetts, tell me, what did you take from it?Shawn: You, you know, cannabis in Massachusetts is interesting because when, when they created their, their laws, so we have in New York, we have two states next to us that both have legalized marijuana. New York state is decriminalized marijuana, but we don't have any dispensaries other than for medical use.But it's interesting. And I'll tell you why the two states were interesting why the Massachusetts one. So we have Vermont, which is the only state ever [00:18:00] to legalize it through. Their actual, like it wasn't like the governor said, Hey, we're gonna legalize it. They actually voted it. The people voted it and said, we're gonna legalize it.But you and I couldn't go to Vermont and buy cannabis because in Vermont you have to be a Vermont resident with a Vermont driver's license or photo ID to buy there. So they're, they're, they're very cut off from it. But Massachusetts is interesting because what Massachusetts is completely legal, they are, were the first state on the east coast to go completely legal.And you think about that. That's the east coast, the whole east coast. They're the first ones. And they tied their marijuana laws to mirror their open container laws for alcohol, which I thought was genius. From the standpoint of, you know, it's not right to walk down the street with an open beer, you know, that I know that we were brought up that way.You know, you could be that person, but you know that the cops will stop you for an open [00:19:00]container. You've heard that. Okay. So they said, we're gonna do the same thing. If you're smoking a joint, walking down the street, don't walk down the street and smoke a joint. If you wanna sit on your front steps and smoke, go right ahead.But what I really gained from that episode in particular was I didn't realize how deep that, and it's a culture. I didn't realize how deep that culture was and really kind of focusing on that and, and listening to, to my guest and saying like, wow, you know, this really is, and we also came up with a dating show.Did you, did you listen to that one, hear about our dating show that we came up with, De'Vannon: do tell, just acted like I've never heard anything before. Okay. Shawn: Cuz this one, this one was pretty funny. So we're talking about it and everything. And we had come up with, you know, how you, you his name was Jarvis Jarvis and I were talking, he goes.You know, you have like [00:20:00] what's the, the rose ceremonies for the bachelorette and all that. And we decided that we could come up with one for cannabis. And instead of giving out roses, you give out buds and the competitions were gonna be like, rolling. How, you know, how good can your partner be? Like rolling?Are they really a road dog for you? Can they hide your stash? If you needed them? Like we had the entire thing fleshed out and I thought, this is great. And hilarious to talk about. He messaged me the other day. He's like, bro, we need to do this. I'm like what? He goes, no, no, I wanna do. I wanna come up with a show and he was dead serious.Cuz from that culture standpoint for a cannabis culture, they're not represented in those worlds. So it was a representation. I thought how great of an idea. And we. BS and on a podcast to come up with this. So that was, that was really kind of the, the nuts and bolts of that one. And it was just so much fun to talk to him about it.De'Vannon: And when you're [00:21:00] saying it's the culture, are you saying the culture of the cannabis or the culture in Massachusetts and of Shawn: culture? Cannabis culture itself. So, so I never thought of it as a culture, you know, growing up, you know, it was, oh, this dude smokes weed, that dude smokes weed. But you never thought about it from a culture standpoint, but when you talk to somebody that's really into it, or, or maybe from a medical standpoint, it's changed their lives, got them off of opioids or, or heavy medications.And you find out that truly it is a cultural thing.De'Vannon: Okay. That reminds me of how before. Franklin D Roosevelt, I believe it was issued this whole war on drugs, nonsense, how, you know, people were doing a lot of psychedelics and everything, and it was really, you know, you might call 'em hippies of what the fuck ever, but, you know, it was people, [00:22:00] you know, bonding over, you know, a, an experience that everyone was having, but it was very much more like a cultural movement than everything like that.Before everything got shut down. And so it sounds like that culture is coming back. Yeah. I mean, ever really went away, but it, you know, it's coming really more back into the mainstream. And so, which I appreciate. And so this leads me to my. Hm, you know, divulge of more of this new journey that I'm on.And so everyone knows my chaotic history being on and off drugs and stuff like that. Well, I watched two documentaries that sold me on psychedelics and I had never used psychedelics before I used to sell them, but I didn't do 'em. Maybe I did ask it, but I never hallucinated or whatever. But so I watched, what do they called the history of mental illnesses on PBS.Then the other one is called how to change your mind, which is [00:23:00] on Netflix. And so, and they both go over how psychedelics were used for health reasons and in clinics before, before the government made it all evil and the devil. And then in my opinion, the church echoed what the government was saying as they tend to do.And how now it's coming back, I'm particularly excited about these MDMA trials and how they've been used to treat veterans and stuff like that, you know, in the VA hospitals, in places and such. And so I'm actually going to go to Oregon. Next month to do an MDA trial thing. And also I'm going to do a psilocybin trial thing while I'm there really like a whole week, cuz everything's legal there and the therapists, you have a lot of these psilocybin centers and, and shit like that.And, and so, and I'm gonna video it of course. And and I hope that I have a total reaction. I did the IV ketamine thing, which is now legal in [00:24:00] all the states. I did not have a good experience with that because I don't think she gave me enough ketamine. And so fuck her. I'm never going back to that clinic.I'm gonna find me a clinic in a more progressive city where they won't mine upping the dose. But but the ketamine thing I did was only like an hour. The MDMA thing is an eight hour day. The SIL side thing is a separate eight hour day . So it's like a completely different. Shawn: Now, now when you're saying you're doing trials, does this mean that it's under the supervision, medical supervision?Is this pharmaceutical supervision? What do you mean by it's a trial? De'Vannon: No, there would be a licensed clinical social worker with me. It's not like a you know, like a, like an NIH, like a health Institute, sanction trial. Okay. My personal trial under the supervision of a medical person. So I'm not gonna go find homey with some MDMA and then be like, let me just and see what happens.No, like I'm, [00:25:00] I'm gonna be coached through the experience and everything like that. And so I'm super looking forward to it because, you know, I've, I've read and heard where these veterans have had things that I struggle with, like PTSD and OCD, you know, addiction to like drugs and shit like that. And they've been able to find whatever level of relief.And so. Shawn: Now is this gonna be like a microdosing thing? Like, I, I, I have a good buddy who, another vet who did the micro, whose brother is a psychologist, which one's an MD psychologist or psychiatrist, which one's the MD. No, I always get it backwards, whichever one's the MD. And he did the microdosing and was in a real bad funk with depression and all that.And he did microdosing and that was life changing for him. And, and he doesn't do it anymore, but he really, it, it helped to break that depression, but it was all microdosing. It wasn't anything [00:26:00]over the top, you know, he, wasn't watching pink bears fighting purple alligators or nothing crazy like that.But yeah, I mean, this is, I wanna hear about this. De'Vannon: I wanna see some goddamn pink bear fighting purple alligators. I guess, I guess what I wanna know is that I really, really had a true outof body experience. But if, for me, it doesn't require me to see strange things for me to get the healing. Then I'll take the healing, but you know, everyone I saw in these documentaries or going through these convulsions and crying and hollering, and it really worked for them.It, it, you have the fit and then you calm 'em the fuck down. And then it's like, you're healed. So for me, it looks like the, the trauma that would in, went into the person is forced out through the MDM a or the LSD or the Mein or the psilocybin or whatever, because that's the way it is. Trauma goes in. It comes out.And when it does, you might holler and holler or whatever. And so I want to know I've been changed. I wanna know I've been touched. Shawn: Well, I was thinking [00:27:00] about you the other day. I have to tell you this. I was watching a video and, and it wasn't one of those kind of videos. It was a different video. Mm-hmm and The gentleman said, you know, we all wanna say that marijuana is the gateway drug.It's not trauma is the gateway drug. If you really look at why people, you just said it yourself, you've had all these issues that fed, you know, your issues in the church and all these other situations for you that fed for your trauma and the drugs. Trauma is the gateway drug. And it, it was such a powerful statement to hear.And I thought about you brother De'Vannon: Ja. So we'll see how it goes. Thank you so much for thinking of me and I will be as transparent as I can legally be. With, with what I intend to do. And so we will go from there and I wanna do all the things now, you know, all the AKA and everything like that. And so, and let's just [00:28:00] see.So for you, out of all the episodes you've recorded, what, what do you think's been the most impactful one to you? You know, one that when you turn the mic off, you just couldn't stop thinking about it, whether you were disturbed, like in a good way or in a not so great way. Shawn: So it's definitely difficult to say that, you know, pick your favorites, you know, it's like they say, pick your favorite child.So I, I, I don't know that, but I will tell you a lot of my guests have become good acquaintances, people I talk to on a regular basis. People I communicate with on a regular basis, I will say though, that probably the one that as a parent. Shocked me the most and really was like, I, I don't know how I would go with this is gentleman named Jeff OWK Jeff is from, and it's funny enough, cuz he's from about two hours, [00:29:00] three hours, south of me in New York.He's from the peak school area of New York. And if you've ever been to peak skill, it's a fairly quiet area. Nothing really goes on there. Jeff, at age 16 was sent to adult prison for a rape and murder. He did not commit. And every, every story you've ever heard where you go, the police can't do that. The police wouldn't do that.16 years old inter you know, interviewing him without a lawyer, without his parents being aware that he's being taken away playing good cop, bad cop not feeding him. And just giving him at 16 coffee and cigarettes and zipping him up and telling him if he doesn't talk, they're gonna whoop his ass.He's gonna go to jail. His parents will be, you know, be charged because they're, they're hiding him, all [00:30:00] these things, his court appoint lawyer, because his family couldn't afford. It never took the time to follow up on BS, evidence on things that just didn't make sense all the way through. I mean, and there's a documentary it's called conviction.It's done by JIA works. And that's how I met Jeff was I interviewed JIA on her. It's J I a and then w E R T Z. She did this documentary on his life and it's on prime, Amazon prime. And, and it's worth watching. It's called conviction, but just watching that and then talking to him and him and I have become good friends.That made such an impact on me as a parent to think that, you know, he, and the reason they picked him out of it all was cuz he was a quiet kid. He was quiet. So today we would say, oh, that kid might have some me mental health issues, but he [00:31:00] did 16 years in jail finally was released when the person who actually committed the crime DNA evidence tied him to the crime and he goes, oh yeah, I did that.Even though Jeff spent all those years in jail and the best part about it though is Jeff got out, Jeff is now got an Esquire after his name, cuz he is a lawyer. And he actually has his own foundation where he defends people that have been wrongly accused and fights for their freedom. So that was probably of, of everybody that I still talk.You know, I talk about all of them. We could talk about the guy, what is aliens, Jesus and the afterlife have in common. That was the week prior to that. And that was one, one of that was some wild shit, but the one with Jeff DYS is probably one of the most impactful in my, in my life life. Like just thinking about things De'Vannon: well is you're right.And I'm taking [00:32:00] my notes and everything like that. Cuz I have to look up these documentaries and everything like that. That, that is very, very useful. Good Lord. Okay. So speaking of fuck, speaking of fucked up childhoods, we're gonna shift gears from your show and talk more about you personally because the people would just fall in love with you, man.And so, so you came from a single parent home cause your dad was arrested when you were young. Mm-hmm where were you born? Where did this happen? Tell us so, Shawn: so I'm. Was an only child. My mother raised me, really. My mother raised me from age 11 to 18 and my dad, my dad did a one year. I always tell people I've never had any problems admitting this.My dad did a one year clip for possession of illegal firearm, cuz he didn't have enough Coke on him at the time for them to put him in jail for that. And my dad dealt, but we, we came from a good life. You know, we had, we owned a liquor [00:33:00] store with a, with a dance club in it. We owned a bar. We were doing good.And we went from that level to my mom, had to sell it all. We moved into a house that didn't have a refer, didn't have a stove in it. We had to wait till she could save up to buy a stove and we used to joke around and call my mom the microwave mama, cuz she could cook anything in a M. And we did. All right.She had a microwave in electric skillet. My mother made it happen. It's actually her birthday today. She turned 70 today. She's a phenomenal woman and, and she made it happen. But you know, I, I was the original, I was like one of those true latchkey kids. You remember latchkey kids that term mm-hmm . So I was a latchkey kid, you know, I, my mom dropped me off at school and then she didn't get home till sometime around five 30.You know, I Def had to fend for myself, which I should have gotten [00:34:00] so much more trouble. I just didn't get caught I just didn't get caught. But yeah, you know, and on my 17th, 17th birthday, my mother knew that I needed more male influences, you know, positive male influences. So 17th birthday, she actually took me to the recruiter's office July 20th, 1993.I had already taken the Ava, went to the recruiter's office, signed up July 21st. I swore in July 6th of 94, I was standing on yellow footprints and headed all, headed down to Paris Allen, standing on the yellow footprints, and then did that for 20 years. But, but you know, I was I was a wayward soul as a kid.I, but I had uncles that, that stepped in and tried to fill that father role. But my uncle who did most of it, he was only eight years older than me. So think about that. He was eight years older than me trying to tell me stuff. So the, the conversations were, [00:35:00] I would almost say they, they had more value cuz they were more relevant, but sometimes I had a, he was closer to a brother than anything.De'Vannon: Okay. And that's your biological dad? So Shawn: my biological dad he popped back. He was back in my life. I guess he was back in my life when I was about 16 and try, you know, he tried, but it wasn't until after I graduated from boot camp that he really, you know, we were back on seeing eye to eye, cuz we didn't see eye to eye before then, you know, eye was that kid, you know, you, you treated my mom bad.You, this, you that. And it, it was tough on me. So it, but it was wasn't till I graduated from boot camp that we kind of were like, I'm a man, you'll talk to me like one. And we treated each other in a different way. [00:36:00]De'Vannon: Well, that's good. I'm here for some reconciliation. So y'all when he says like, as valve that stands for arm services, vocational aptitude battery test, you gotta take.Before you can scoot off to the military latchkey kid is just like a kid is at home without adult supervision. Just kinda like a key you know? So, so you said you knew your dad was, was dealing this cocaine. Oh yeah. So how old were you when you first became aware that he was dealing the Shawn: drugs? I guess I was probably, well, I guess it was probably right around when my parents divorced at age 11.And even that, like, I still remember that I was asleep in bed, woke up to my mother, waking me up, going, I'm putting your father's stuff in trash bags and putting it outside. And I went okay. And went right back to sleep. It had 0.0 impact on me at that point. That's what you're doing. Okay. Fine. I don't give a shit.He ain't around anyway. [00:37:00] He ain't, he ain't here. And but I was probably about that age, but even before then, like, My dad smoked weed, always did. And, and I knew, like I knew how to put it. I knew what it was, but I didn't know what it was, if that makes sense to say it in that way with different inflection.Like I knew dad's got a stash underneath this couch, it's in this bag. I don't touch it because it's dads didn't know what it did. Didn't know what it meant, but I just knew I didn't touch it. De'Vannon: Okay. I can understand that. I remember watching like an older sibling of mine like I think vomit up cocaine, you know, when I was like, you know, super young and I didn't really know what it was.Maybe I kind of knew it. It's kinda like, it's kind of like a, a foreboding sense of knowing I get that. Mm-hmm so let me be clear. So you had like a biological dad and a stepdad, or are we talking about this person? No, no. So Shawn: I had, I had my [00:38:00] biological father and then I had an uncle who was eight years older than me who really.Was the major male role model and help helped get me through high school and everything. De'Vannon: Okay. Okay. So now you also told me before that you personally were divorced twice and you were married three times. So do you feel like watching what happened with your parents attributed to your situation? Or was it cuz you were in the military or what do you think?Shawn: You know, I, I would say the, the first one was very military. You know, it was that it, and they don't, this is probably one of those things. I think we don't do enough. Good jobs with in the services is dealing with separation anxiety. You know, I was a 17 year old kid when I went to boot camp, turned to 18 in boot camp.Here I am. I'm gonna show up in Jacksonville, North Carolina, I got bills to [00:39:00] pay. I've gotta get myself going. I'm I'm on my own. And the only people that tell me, they love me or care for me are back home. So, but I can't be there every day. So why, if I can get one of those people to come with me and tell me that they love me again, why wouldn't I do it?So that was my first marriage. Good woman have no, no ill things. We've talked years later, we talked afterwards, cuz we were probably married for months. Like we're legally married for a year, but we were only together for a few months after we, we got married and we were high school sweethearts, but I have, we've talked years later and you know, looking back, she was like, oh, I'm sorry, this, that, and the other I'm like, it's fine.I understand. We were kids. I was like, she was 18 and I was 20, you know, we were kids. Like I turned 20 just after we got married and we were kids. [00:40:00] Which shouldn't have ever happened, but it was separation anxiety that caused that. The second one, it was military related stress. I promise you it was a, it takes a special person to be a military spouse.It truly does. You have to be a kind of person who can operate on their own with minimal interaction from the other person and be willing when that other person shows up to allow them to assert whatever force they have in it. But at the same time that service member has to be understand that you're not around all the time.So the rules have already been set. You have to find out what those rules are and let whoever's been leading that charge, tell you what the rules are and it's tough. So I went, I was on recruiting duty at the time. I was probably working 70 plus hours a week, not home getting up at crack of Dawn driving at this time.It was I was. Driving from [00:41:00] Redding, Pennsylvania to ha or horse from Pennsylvania about an hour, hour and a half each way. Every day, because the housing crash happened. We were at one, one, I was in charge of one location. They switched locations. And it was really just that stress finally broke our marriage.So De'Vannon: it's hard to be in a relationship period where you've got two different people who exist in two different worlds. And you're trying to figure out a way to make those collide without destroying each other one another. And so a military relationship, like what saying the chaotic nature of it is something I witnessed when I was an air force recruiter because some of the wives are the, you know, would be military wives.You know, they really couldn't handle it. Like they didn't. You know, he's gonna go to the military, but why should I [00:42:00] leave my mom and my sister, you know, is something the girl might think. And so I really feel like they should do like the military do like coaching and transition training and things like that for the spouses and stuff like that.I'm not overly fond of necessarily the way the military gets people ready to either enlist or to come out of the service. And so I feel like there's more that can be done both going in and coming out, but a lot, lot of, a lot, a lot of, a lot of, a lot of the women really had to come home. And I, and I see women because I really wasn't around a lot of females, you know, was only around guys and they had wives because unfortunately I was entering don't don't tell.And so, oh my gosh. I can only imagine the gay parties they're having in the fucking military now without me. shit. so, so, so wait, so you, you, you mentioned Before that you were always trying to [00:43:00] get married mm-hmm . And that, that sort of statement reminds me of Ernest Hemingway you know, very popular author and everything like that.And I watched documentaries on Ernest Hemingway and you know, he was an alcoholic and some might say a narcissist and a few other things, but there was a thing with him, with Mr. Hemingway, where he was always, always married, you know, he would like meet a woman and be like, I want you to be my wife, you know, while he still had another wife, you know, and then he, you know, she would be getting along, you know, he would, he'd be scooting her along sooner or later.But, you know, when I read that from my notes about you, that you were always trying to get married, it reminded me of Ernest Hemingway. Now you have an Ernest Hemingway is type beard going on right now. And so talk to me about this needed to be married. Shawn: You know, I, I think it, it was that It goes back to that [00:44:00] separation, anxiety being alone.Like I said, I mean, if I look at my, my life, like I said, latchkey kid, I was always by myself unless I went to a friend's house, get into the service. I separate myself from anything that I can consider as a connection and I have to build my own. So why not bring that connection with me? It, it took a lot of years before I could be on my own.And I think I, I attributed for a long time being married with being with someone, if that makes sense, like having someone else in my life, that's how you fill that space, whether it was good or bad. That's how you did it. Are you still De'Vannon: married? IShawn: am. I'm now I've been married to my wife now for five years.Very happy, much more mature relationship too, though. You know, I was much older. When I [00:45:00] got married, we both had careers. We both had lives. We both know how to, we, we can, at this point in my life, I can function differently. I don't need, I love spending time with my wife and doing things with my wife.I enjoy that, but we don't have to be up each other's as to, to feel that. And, and to, to have that trust factor, De'Vannon: right. I say, wait till you're at least 30, you know, all in my twenties, I used to think I knew who I was and I was an adult. It wasn't until I was like in my lower thirties that I really think I solidified who I was so slow down when y'all, there's no need to get married, do all the traveling, do all your experimentations, whatever, and then save all this getting kids and all that for later to darling, there's no need to rush.Shawn: And if you can avoid kids, just avoid it completely. I have so much more money. I love my children, but God, I always think about, that's see, this is something that once you have children, you [00:46:00] think about all the time. Like, God, I love my kids, but man, if I didn't have y'all, do you know how much money I would have?De'Vannon: I'd be paid. Shawn: I think a little S De'Vannon: I'd say I say that about my cats, but you know, they're probably only $30 a Shawn: month. Yeah, no, your cats are good. Like between a bag of food. And if you have like healthcare for them, you know, the cats are good here. There there's no problem with them. I've got two and I love my cats.So you De'Vannon: mentioned like yellow footprints. A couple times when you, what, what is that like when you talk about chipping off to the Marine, what is that? Shawn: So that's the, a very iconic Marine Corps thing. So if you look up yellow footprints, when you step off the bus at Paris island, or if you're from the left coast in San Diego, there are painted on the ground yellow footprints because that's where you have to stand.And they're painted at a 45 degree angle because that's where your feet need to go. So that to start teaching you the position of attention right away. So that's, [00:47:00] so you'll hear Marines, talk about, you know, landing on the yellow footprints or standing on the yellow footprints. De'Vannon: Paris island is the Marine Corps bootcamp.Right? We Shawn: have two. We have. So if you're east of the Mississippi, you go to Paris island. If you're west of the Mississippi, you go to San De'Vannon: Diego. Mm. I would've gone to Sango. Sango does Mississippi river runs right through Baton Rouge where I'm at on the west. Atton Rouge, Shawn: Baton and love Louisiana. I have to tell you that I love Louisiana.I've only been once and I would, I've been once and I would pack my shit up and move. Okay, De'Vannon: well, you can come here and then I'll go to Los Angeles. Shawn: Well, I'm in, well, I'm in all small Albany, New York. So you, you have to come to small Albany if we're gonna swap. De'Vannon: Oh, didn't you mention New York. There is a, a people of color psychedelics collective.That's a lady heads out of New York who I hope to have on my show. What it's like a whole nonprofit. And it's all about like the benefits of psychedelics and shit. [00:48:00] It's like the people of color psychedelic collective. It's like a thing. People Shawn: of color psychedelic, collective , De'Vannon: Yas . And so Shawn: P O S C C De'Vannon: Paska, something like that.But if I can get ahold of her and set it up, I will be flying my black queer ass to New York so I can get high on whatever the shit, whatever. Fuck I can give my hands on. If, Shawn: if you can get her on your show, I expect that you introduce me to her so I can have her on my show cuz I would love, see, that's see that's my show in a nutshell, somebody being like, I got this person, this is what they do.And, and I always tell people, my show should feel like you walked into a bar and you're overhearing somebody else's conversation. And, and if you're the guest that should feel like you walked in the bar and the bartender goes, Hey, you do that drugs in Jesus thing, right? yes, I have a podcast. And that's what it should feel like ad hearing that, oh God, I [00:49:00] would love to talk to her.What's her name there is she now De'Vannon: I've made a note. We'll talk about it. call. What is she call her now? Shawn: oh, De'Vannon: so great. So, so you were in the Marines and I have to say Marines are very sexy. Love the outfits and the uniforms. Was there any sort of scandalous, was there any kind of gay sex that you saw in bootcamp in training?I wanna know some tea, some dirt, some Marine, so Shawn: drama. So nothing that I ever ran into personally, like nobody that ever directly came on me. I'm not, I guess I wasn't that cute. I was, I was five, seven, a hundred twenty seven pounds when I got in. So it had to been into it to, into twinks or something like that to have looked at me that way.But but there was always stories. So for example, I remember in my first command, there was a Marine. I actually remember his name, but I won't say his name who. Ran down to the duty office, which was in the duty office is a Marine who's [00:50:00] in charge of the barracks for that day, making sure that nothing bad happens, reports on it.He ran down to the duty office, but booty naked because his roommate who was a big dude, and this guy was like 5, 1 52. And his roommate was a big dude, was standing at his door when he came out of the shower and basically tried to have his way with him, snatched his towel off of him and everything. And the only reason I remember this is because as I was checking in to our command that day, he was in handcuffs, leaving De'Vannon: who, the skinny guy or Shawn: the big guy, the big guy, the, he was in handcuffs leaving.So, so there was that, but probably the next big, I, next time I heard anything was Let's see what year would've been like 99, 2000 timeframe. It was right around in North Carolina. We had two hurricanes, hurricane Bertha and hurricane Fran. They were back [00:51:00] to back and they did a lot of damage. And so some of us got, you know, this was the only time I ever heard where they were like, go home, stay away from the area.Come back when it's clear. So I had come back and joking around. We had put a sign on one of my buddies trucks that just said he, he didn't know it. They had ziptied this big cardboard sign that said I'm gay. Everybody thought it was funny. He hadn't seen the sign. Ha ha ha. No big deal. All sudden our mass Sergeant comes out and flips on all of us.Get that shit off his truck. You don't know what's going on around here, blah, blah, blah. And we're all like, whoa, mess starting. Why, why are you flipping out on us? So we take it off. We'll come to find out one of the Marines who hadn't come back yet. Had just shown up. To our CO's office walked into the CO's office with a local lawyer and went, we would like him discharged outta the Marine court right now.He's gay and he's concerned [00:52:00] that if it other people within this command find out that he's gonna be physically assaulted and they had him out of the service in a day, at a day, he was gone. So those were two incidences, but I will tell you knowing Marines the way I do, I come from a pretty open household, grew up with an aunt who was gay, never thought nothing of it knew new people who were gay, growing up.Never thought anything of it. It was always just kind of like O okay, do you boo? I don't care. But when I found. Somebody didn't tell me they were gay. And it was somebody I was very close to was another Marine. And I found out after they had gotten out and they told me that I was kind of like, damn bro, why didn't you, why didn't you confront talk to me about this before you'd have been good.And it was because [00:53:00] I acted like a Marine and, and I, and I say that in quotes, that he was concerned that I would, I would see him in a different light. And that really hurt because I was just being a Marine and that rah yet, you know, loud, you know, over, over the top male kind of persona. And that was one of those things that really hurt me.Cause I was like, damn bro. I thought we were good like that. And, and they were like, yeah, man, I couldn't tell you. And I was concerned that you would feel a certain way about me and I didn't want you to know. And I was. I actually yelled at him and was like, Hey motherfucker, why didn't you tell me? And then he told me that and I was like, and that actually hurt my feelings.Cause I was like, man, did I, did I make somebody feel that way than I shouldn't have De'Vannon: it? Wasn't you? It was the environment of the military. You know, he didn't wanna lose his livelihood and he didn't tell you or anyone else, unless it was someone else who was not, who was [00:54:00] clearly queer, but you know, which you don't present that way.And so ain't nobody gonna risk their, you know, their income and everything because they wanna have a, an open conversation with somebody because you never know how those things are gonna go. So I wouldn't take it personally. He was just trying to survive. Well, Shawn: years later, I, I we've talked about it more.He's my closest friend, my best friend, but, but it really was, it was kind of one of those things where I was like, damn bro. Initially it really caught me off guard. Mm-hmm De'Vannon: so as a Marine recruiter, did they tell you to lie? Shawn: No. Nope. And that was always one of those things. Like, I, I always will tell people this, I never lied about it.That was actually the big difference between the Marine Corps from a recruiting standpoint and maybe other services. I don't know, only because we wanted to tell you how bad it sucked. We wanted to tell you how hard it was. We wanted you to know that this was gonna be the like boot camp was gonna be hard.It was gonna be [00:55:00] miserable. It was gonna suck. You're gonna sweat. You're gonna question the fact that you even met me and ever did this. We wanted you to feel like that because that was part of the sell because people wanted people wanna be like, fuck that I could do that shit. You ain't gonna scare me off.I'll make that shit happen. It was part of the sell. De'Vannon: That's some good reverse psychology right there and playing on the male ego. See when I was an air force recruiter. They would try to get me to lie to the recruits about like their career. So like if I had a recruit who wanted to be a weatherman or work in avionics, I would work to get him that job, what the higher ups in the air force would do.And in, in, as soon as I asked you that this, this question, I realized that this, the response would probably vary on who your supervisor was at exactly where you were recruiting at. So so they would do some shit in the air force, [00:56:00] like book the guy in like a security forces, this job to be a police or whatever.And then they'll be like, we're just gonna go ahead and assign him this job. We've disregarded what he wants to do. And we want you to bring him into the office and act like, you know, this is the best job ever sell him on this job, you know? That's the sort of shit that they would try to get me to do in the air force.So that what you're talking about is just a little bit of free decor. Shawn: Yeah. Like we were, so that was our move. Like I kid you not there's, this is a real thing. You would walk in front of a crowd of kids and you would look around and be like, I don't think most of you could do be in the Marine Corps. Here's a little bit about it.If you, the one or, and, and this would be a move, you'd go. The one or two of you that I see in the room and you would look, you would never actually make eye contact with anyone. You would do this be like the one or two of you that are in here that probably could do it. You can come meet me in the back of the room when this is all [00:57:00] over with.And you would get like five or six of 'em, cuz these idiots would be like, I'm, he's talking to me. I know I'm I could do it and you'd stand there. And it, you never looked at anybody, but it was just let me see if I can hype you up enough. And it was a thing. You know, I used to tell kids all the time, you're gonna hate the day you met me within the, the first couple hours that you're at Paris island.You're gonna hate the day you met me. And they'd be like, what? I'm like. Yeah, that shit sucks. De'Vannon: Okay. Bootcamp is a motherfucker. Oh hot, Shawn: hot, like you. I went to bootcamp in July, South Carolina in July. I here's how hot it was. You wanna know how hot it was? De'Vannon: I was in San Antonio in July and August for mine.And so we were clearly in the 100, 1520 degrees. It was Shawn: so hot in South Carolina in July of 94, they used to have a pool outside that [00:58:00] we did our swim calls in. It was an outside swim call. It was so hot. The pool water felt like bath water, and it wasn't heated. That's how hot it was. Think about that.Getting in a pool and being like, I'm gonna get in this pool and cool down. This shit feels like bathwater.De'Vannon: Well, I'm glad you didn't melt. Shawn: Nope. Nope. No, all this sweetness made it through. So do you feel like movies, De'Vannon: like I think like Jarhead a full metal jacket do the Marine, I think that those were like Marine specific mm-hmm if I'm not mistaken, do you feel like they do the Marines? You know, is that really how it is or there's really soap party there.Y'all beating people up at night, you know, you know, Shawn: I know what you're asking, so, so I'll put it like, yes, I think full metal jacket. There's a lot of [00:59:00] legit because of the fact that AR EY who plays the drill instructor was a Marine drill instructor. And I think a lot of it from that era is legit fast forward today.No, nobody's pulling out bars of soap and beating some eye's ass or something like that. Jarhead I think is one of the worst movies ever made bar none. By far the biggest load of bullshit I've ever watched it should be burned and never played again anywhere. It's so bad. The fact that Jamie Fox plays a staff, Sergeant that an E two private first class runs his mouth to him.Like he's a punk at one point in that movie, that's not happening. That's that's not happening. And they talk about if you watch that movie, when the main character, the, of the movie ends and he goes to his buddy's funeral, he's [01:00:00] still in E two. After four years, you will get promoted three months outta bootcamp to E two, six months after that to E three, if you haven't, if you're not again, At least picked up E three and got out.You're a turd, you're a turd of a Marine and you're getting in trouble on a regular basis. And really, I got nothing for you. So I can't stand the, can you tell, I don't like that movie. De'Vannon: a scathing review. Y'all yeah. Shawn: I, I just, I think it's a garbage and a friend of mine read the book another Marine and said the book was really good and he's like, man, don't don't judge the movie.Don't judge the book by the movie. He's like, the book is really good. He really gets into some details of things. I I'll tell you one that I really talk about eye opening things, not to, to switch sides here. There's a book called shadow of the sword that I really wish they would make into a movie. [01:01:00]It's about a Marine who is a, I can't remember if he's a bronze star with a, with a V, which is a pretty high commendation for valor, or he was a Flying across, which is one step below the medal of honor winner.But ver awarded for valor honor went to, went to become a drill instructor and suffered such PTSD that it broke him. But to I have his book, but to read his story, shadow the sword and to hear like I wasn't trying to be a hero. My body took over and just did things because my friends were there and I needed to survive that they needed to survive that.And just the way he explains it in his, the aftermath of, of dealing with things afterwards and, and going through the PTSD like this dude talks about in the book, his [01:02:00] NAB, he was at his in-law's house and the neighbor's dog wouldn't stop barking at him. So he jumped over the fence and started choking the dog to death, like bare hand, choking the dog to death.That's a P you know, people be like, oh, you're an asshole. Or you're psycho. No, that's a PTSD reaction. And if they want, if Hollywood, Hollywood, if you're listening, go get the book shadow of a shadow of the sword and go make that into a movie. Go treat that the way it should be and treat the service members the way we should be treated.We lose 22 vets a day to suicide a day. So about my shows, I interviewed a gentleman who had his own organization called 22, 22 a day. Vet lives matter. He committed suicide and he had an organization. He had people around him. He. De'Vannon: Well, since you mentioned suicide, I had put a note here and I'm so glad to see they were on the same page with, I wanted to talk about veteran suicide.[01:03:00]And I pulled up some statistics from back in 2020, and it said that the army had the highest rate of suicide in 2020, at 36.4 death per 100,000 soldiers. So basically this is 580 total service members who died in 20, 20, 30% were active duty, the Marine Corps at the second highest suicide rate, 33.9 death per 100,000 Marines Shawn: that I'm not surprised by those numbers.I mean, ho ho every day, you know, it's most of us go to work just to get the job done. You would agree with that. You know, the average civilian goes to work just to get the job done. Well. Yeah, they do, but. How about you go to work and every day get told you need to do it better than you did the day prior.You need to, you need to hold yourself at that next step level. There is no doing it easier. And if you try to take the easy way, [01:04:00] you're a skater, you're a slouch, you're a turd, you're everything under the sun. So you must perform at that next step. Do that every day and then come out and be around people who don't understand that mindset, do that every day and for four years, and then come out to a place where you're like, you're right.This fucking has how work. This is how I do things and then turn around and see everybody else not performing at that level. Tell me what that does to your mindset. De'Vannon: For me, it made me narcissistic and arrogant because, because the military told me that, you know, I'm Superman, I'm better than everyone else.This alludes to what I was saying earlier about better training people to exit the military, you know, in bootcamp and throughout military, they prime us to be on this pedestal and they, we can't, you can't function that way in society and PTSD is real. I struggle with it. It's one thing for me to [01:05:00]have a one hour conversation with you, but for me to try to immerse myself in a day to day work environment with people is impossible because I'm constantly judging them.It's the military's voice in my head judging them. It's not really the say for instance, the end of the world in the military. They're always saying if you're 15 minutes, late, 15 minutes, if you're 15 minutes early for an appointment, then you're on time. 14 minutes. You're late, early, you're late in the civilian world.It's actually not a catastrophe if you're running a few minutes late, but goddamn in the military. So, so with people, I have to stop myself. If they're like a minute or five behind from looking at them, like they're the goddamn devil , you know, to this day. And I've been out of the military for almost fucked, you know, going on 20 years, you know, to this day, I'm all like, it's okay if they're two or three minutes late the van.And I have to like talk myself down from wanting to burn them with kerosene and brimstone when they show [01:06:00] up, you know? But we, we judge people irrationally. We judge ourselves, whatever we do, isn't good enough. We beat ourselves up because the military told us whatever we did is never enough. 99.9% on a test is, is terrible.It should have been 100. You know, I have Shawn: to get that one wrong. you De'Vannon: know, how dare you get that one wrong? Well, I mean, Shawn: you, you bring that up. You, you talk about the test that was, you know, you go through your entire life in school. Hey, I got a 60, I passed it still. That's a D get into the military, 80 to 85 is passing.If you get anything below an 80 or an 85, depending upon what, what courses you're taking, you failed. So, I mean, right there, you you're, you're on a different level right away. De'Vannon: And so, you know, learning how to deal with society even all these years later is just like, it's still a thing. And so that's why I'm all for all of these psychedelics, whatever [01:07:00] can help me deal with the O C D and the PT, PT, S D I think every veteran should have a license to do whatever fucking drugs we want and just be done with it.And so. You were I just, so we're just gonna talk about one more thing and then I just have positive advice for the veterans. And so you were in during nine 11 as much as I hate how divided an
Thank you to Kyle for commissioning this episode!These chapters are the ones in where Thera tries to pull back on her authority in their little camp and let the Agon people take the reigns a little more. Her uncle-in-law comes to them with a suggestion that I'm highly suspicious of. But by far the most upsetting thing is Jia's creation of a drug that can ruin entire communities. I hate this so much. Thank you for listening, and I will see you soon with a new episode!
Sam, John, Chase, and JIA breakdown the Cavs trade for Donovan Mitchell. Produced by: Chase Smith The Press Play Podcast Network Follow us on Twitter: @cavsonthebreak / @pressplaypods For Sponsorship plans and more information, please email: firstname.lastname@example.org To listen to all our shows and learn more about our network, please visit www.pressplaypodcasts.com
What are your patients reading on their smart phone and how accurate is it? Drs. Drew Carey and Lorraine Provencher team up to answer this question from Dr. Natasha Nayak Kolomeyer as they discuss her Ophthalmology Glaucoma article, “What Glaucoma Patients Are Reading on the Internet: A Systematic Analysis of Online Glaucoma Content.” What Glaucoma Patients Are Reading on the Internet. Jia, Jing (Sasha) et al. Ophthalmology Glaucoma, Volume 5, Issue 4, 447 – 451.
Thank you very much to Kyle for commissioning this episode!These are some fascinating chapters, and also a little saddening for me personally. Because of my personal dislike for Jia, I assumed that her assurances that Phyro isn't ready for the throne were just a ploy for her to retain power. But the more we get to see of this situation, the more correct she seems to be. Even Zomi believes Jia is right. I'm still not loving Jia being in charge tho. Thanks so much to you all for listening, and I will see you very soon with a new episode!
Thank you to Kyle for commissioning this episode!So we're doing the thing where we jump ahead a few years and we get to see the ways in which cultures clash against one another, and the variety of ways in which value systems that don't match can lead to deep misunderstandings and feelings of superiority that get in the way of effective communication. Also, we go to the palace for the first time in a while and see what's going on with Fara, Phyro, and Jia. Seems like Fara is better at this than anyone is really giving her credit for, but her brother is not inclined to take advice from her. Thanks to you all for listening, and I will see you soon with a new episode!
On this encore episode of the Psychology Talk Podcast Dr. Hoye interviews Dr. Jia Gottlieb, M.D. about his new book, "Aah…The Pleasure Book." Dr. Hoye and Dr. Jia discuss the concept of pleasure from an Epicurean perspective. They dive deep into the issue of pleasure having been placed on the back burner, so to speak, culturally for 1600 years. Dr. Jia spells out how pleasure drives us towards curiosity in life and discovery of the mysteries of the universe. They discuss the neurology of pleasure in the three basic structures of the brain, and how they can be mapped into a four-stage model of pleasure.The control of pleasure is all around us: our reward systems of our brains these having been relegated to the click of a mouse of a “like” on social media platforms, and by hierarchical structures misleading us to only find pleasure in endless consumption, monolithic, homogenous cultures, and dogmatic religious structues. How can we salvage and orient ourselves to the practical, Epicurean philosophy of pleasure, and better control our minds and lives through freedom? Listen in to find out. Dr. Jia was born to an Austrian Jewish father and Chinese mother and grew up in a white, middle-class suburb outside of Chicago. After graduating from college, he backpacked around the world for a year. During a 12-day trek in the Himalayas, he found his calling as a doctor. He received his MD from Northwestern University, completed his residency in family medicine at the Community Hospital of Sonoma County, California, and then traveled to China, Japan, and India to study acupuncture, martial arts, yoga, and other ancient practices. Shortly after returning to the States, Dr. Gottlieb established Still Mountain Clinic in Boulder, Colorado, where he provided patients a unique therapeutic approach based on his extensive training in both Western medicine and Eastern healing artDr. Jia's Website:https://jiagottliebmd.comDr. Jia's Book: https://www.amazon.com/aah-Pleasure-Book/dp/1734376902/ref=sr_1_1?dchild=1&keywords=aah+the+pleasure+book&qid=1592507431&sr=8-1The Psychology Talk Podcast is a unique conversation about psychology around the globe. Your host Dr. Scott Hoye discusses psychology with mental health practitioners and experts to keep you informed about issues and trends in the industry. https://psych-talk.comhttps://www.instagram.com/psychtalkpodcast/https://www.facebook.com/psychtalkpodcast
My guest today is Dr Jia Ng, who is a board-certified nephrologist and a clinical researcher at the Zucker School of Medicine at Hofstra/ Northwell. She is also the founder of PublishedMD, where she helps clinicians publish research papers by up-leveling their research and academic writing skills through digital products, so that they can build authority and achieve their academic goals. She shares her story of extreme physiologic exhaustion during fellowship, and how her experience not only changed the way she took care of herself, but also her self-concept, moving from imposter syndrome to feeling that she was a part of a community. To learn more about Dr Jia's work, you'll find her in the following places. Check out my youtube channel. I give bitesize tips on how to write papers, and how to have a smooth academic life. https://www.youtube.com/c/PublishedMD Website: www.publishedmd.com Instagram: @publishedmd Facebook: https://www.facebook.com/jia.ng.31 LinkedIn: https://www.linkedin.com/in/jiahweing/ Twitter: @jiahweingAre you a Physician struggling with perfectionism? Do you believe if you just worked harder you would figure it out, but you are too exhausted to try? If so, I invite you to check out my upcoming program, Healing Perfectionism in Physicians. This program is designed to help you let go of perfectionism, people-pleasing and frustration, and find more joy, authenticity and self-compassion. Click here to learn more.
Coin Concede: A Hearthstone Podcast
Remember how last week was Shamanstone? Well, it's Rogue o'clock now - or at least it was when we recorded this. Join in to hear the gang's thoughts on where standard has gone after the most recent balance patch. News – 27:15 Patch 24.0.3 and a pile of changes And a lot of patch notes and twitlongers Jia! Tournaments – 1:37:21 MT Murder GM Last Call Week 3 Decksplanations – 1:48:50 Rogue! AAECAaIHBKH5A+2ABJGfBPbdBA2q6wP+7gOh9AO9gASUnwT2nwT3nwT7pQT5rAS3swT03QT13QTBgwUA The Show Notes for this week's episode are on our Website You can monetarily support our show on Patreon Join us every week live, by following us on Twitch Join our community chats in our Discord channels and write in to our Email Follow us on Twitter as well as like share and follow us on Facebook Save our RSS feed or subscribe to us on iTunes, Stitcher, or Google Music Play. And please leave a review on iTunes or Stitcher
Faith Louise Cooper:I'm a Certified Nutritionist, Coach, Speaker & Chronic Condition PatientI grew up in a home with a sister who is a childhood cancer survivor and I found that there was little support for the siblings of children diagnosed with a chronic condition.I was also diagnosed with JRA (now JIA) at the age of 12 and felt alone in the fight against the condition that none of my peers could understand during my teenage years.Support the show
Hello from the miserable gap between episodes of “Extraordinary Attorney Woo”!This week, Jay and Tammy are joined by the great Jia Tolentino, a writer at The New Yorker and the author of Trick Mirror.We start by talking about Jia’s recent piece on housing (= the rent is too damn high) on the worker-owned site “Hellgate”—and her dreams of organizing her building (not Tammy’s “white projects”) in Fort Greene, Brooklyn, New York. Then, we discuss two provocative essays Jia wrote on abortion after the Dobbs decision: first, on surveillance statism; and second, on the moral (especially Judeo-Christian) sacrifices inherent to pregnancy and human existence, not just to abortion. Plus: Jay and Tammy review Las Vegas's Sino-Korean noodles. As always, thanks to our wonderful producer Mai and all of our subscribers (Jia included!) for keeping the show alive. On Thursday, August 25th, we’ll have our next book club meeting with Lisa Hsiao Chen, the author of the novel Activities of Daily Living. Subscribe via Patreon or Substack to join. This is a public episode. If you’d like to discuss this with other subscribers or get access to bonus episodes, visit goodbye.substack.com/subscribe
País Estados Unidos Dirección Adam Wingard Guion Eric Pearson, Max Borenstein. Historia: Terry Rossio, Michael Dougherty, Zach Shields Música Junkie XL Fotografía Ben Seresin Reparto Alexander Skarsgård, Rebecca Hall, Demian Bichir, Millie Bobby Brown, Eiza González, Shun Oguri, Kyle Chandler, Kaylee Hottle, Julian Dennison, Van Marten, Jessica Henwick, Lance Reddick, Brian Tyree Henry Sinopsis Godzilla y Kong, dos de las fuerzas más poderosas de un planeta habitado por todo tipo de aterradoras criaturas, se enfrentan en un espectacular combate que sacude los cimientos de la humanidad. Kong y sus protectores emprenderán un peligroso viaje para encontrar su verdadero hogar. Con ellos está Jia, una joven huérfana con la que el gigante tiene un vínculo único y poderoso. En el camino se cruzan inesperadamente con el de un Godzilla enfurecido que va causando destrucción a su paso por el mundo. El choque épico entre los dos titanes -provocado por fuerzas invisibles- es solo el comienzo del misterio que se esconde en las profundidades del núcleo de la Tierra.
Jia is a staff writer at the New Yorker and a bestselling author of the nine-part essay collection “Trick Mirror: Reflections on Self-Delusion,”. On this episode, Jia talks about her latest writing on the Supreme Court's abortion decision, coping as a new mother, and how her religious past influenced her writing. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Kings and Generals: History for our Future
Last time we spoke, Yang Sichang had enacted his “ten-sided net” plan and won a multitude of victories over rebels. However this plan proved to be a disaster overall and cost the Ming Dynasty more than it did any good. Now Li Zicheng had established himself as the de facto largest rebel leader amongst others who now held entire armies at their command. The Ming dynasty was rotting from within and its actions to prevent the rot simply delayed or sometimes even made it worse. With the allocation of so many resources to the northwest and center of China to deal with the rebels, the Ming northeastern frontier was weaker than ever. Seeing the absolute turmoil from within, the Qing soon realized they could allow the rebels to do much of the heavy lifting for them for now it was time for the Qing to overthrow one of the greatest dynasties in history. Welcome to the Fall and Rise of China Podcast, I am your dutiful host Craig Watson. But, before we start I want to also remind you this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Perhaps you want to learn more about the history of Asia? Kings and Generals have an assortment of episodes on world war two and much more so go give them a look over on Youtube. So please subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry for some more history related content, over on my channel, the Pacific War Channel where I cover the history of China and Japan from the 19th century until the end of the Pacific War. This episode is the fall of the Ming Dynasty As things only worsened within the Ming dynasty, soon the Qing would make their move in one of the most decisive engagements fought between the 2 empires. Given the Ming's recent ability to withstand the Qing raids over the past few years, the Ming Court remained a bit more optimistic that the northeast could hold out. Hong Chengchou continuously argued they should remain defensive despite many in the Ming court pushing for offensive operations. Despite this, the Qing were making massive efforts at digging trenches for some upcoming sieges. By some estimates some trenches were 8 feet deep and 6 feet wide, dug in several rows. The siege efforts represented an evolution in Qing warfare, many differing groups were being employed and specialization was being seen. For example Koreans were manning many of the firearms and Mongols were used more for mobile warfare. At Jinzhou some Ming relief forces began to advance and upon hearing the firing of their guns, the defenders burst out of the south gate. The Ming engaged the Qing who had sent 7000 cavalry to hit them. A fierce battle was fought, but the Qing were able to move their cannons and used them to devastate the Ming. The defenders were badly hurt, having 738 dead and 793 wounded, but the Qing eventually turned away by nightfall. Despite this being a slight victory for the Ming, they had only months worth of supplies and were advised by Zu Dashou not to enter any battles lightly. But the Ming Court kept demanding more offensive operations, pushing Hong Chengchou to go forth with a force of 60,000 in July of 1641 to hit the Qing. The Qing forces were around Mount Rufeng, due south of Jinzhou. When Dorgon heard the report of 60,000 Ming incoming he urgently sent a message to Hung for aid. Hung told Dorgon to stand firm and sent him 3000 cavalry immediately to help out. Estimates vary, but its possible the Qing had up to 100,000 men in many elevated positions amongst all the siege works. When Hung arrived to the scene he stated “They say Hong Chengchou knows how to use troops. I can see that those aren't empty claims. My generals should be concerned”. Some of Hong's commanders advised a retreat, stating their supply was short, but Hong stated “now today we have this opportunity and although our food supplies are growing short, you should listen to the order of your officers. If you defend, you may die, but if you don't fight, then you'll still die, but only in battle do you have any hope of a favorable outcome”. Thus Hong led the attack personally against Hung's forces. This is getting a big confusing eh with the Hung and Hong? Hong's left and right flanks advanced haphazardly and were quickly routed by the Qing. The next day the Ming left flank panicked and fled, trampling into another and abandoning many weapons and supplies while falling victim to more Qing ambushes along the way. Over 50,000 Ming troops were lost, literally being driven into the sea. Of the left flank it is said barely 200 men survived, being ambushed all the way to Ningyuan. The left flank commander, Wang Pu would be executed for this terrible conduct. Hong Chengchou and the right flank made a fighting retreat all the way to Songshan with only 10,000 troops. Hong vowed to hold Songshan to the death with these forces, but now Jinzhou was more isolated and thus in grave danger. As the Ming dug in further, Hung told his forces all they had to do was sever the Ming supply lines and defend the coast, because the Ming were short on food and soon would fall apart. Hung returned to Shenyang and left the siege in the hands of his commanders, Dodo, Jirgalang an Abatai. Upon hearing the news, Chongzhen ordered Hong to fight to the death if necessary to protect Songshan. As the siege continued the defenders pleaded with the court to send supplies while they had only a single bowl of rice per day to survive on. Things did not fare much better for the besiegers who were also low on food supplies. It would actually be Songshan that turned itself over to the Qing before Jinzhou, in march of 1642. At Jinzhou the defenders eventually resorted to cannibalism and this finally prompted Zu Dashou to surrender the city to the Qing. Next Tashan fell with 7000 of its defenders being massacred. Xingshan fell afterwards peacefully. Many of the Ming commanders were brought to Shenyang. Eventually Hong Chengchou after refusing to eat for several days agreed to defect to the Qing, becoming the newest most prominent Ming to do so. Hong Chengchou joined the Yellow banner, working under Dorgon. These victories, now called the battle of Song-Jin allowed the Qing to acquire a ton of war equipment. They got their hands on 3683 cannons and 1515 various guns. Now it seemed the Qing had the necessary technological tools capable of toppling the Ming Dynasty. Hong Chongzhen just before the fall of Songshan and Jinzhou proposed opening up peace talks with the Qing. But knowing the emperor's temper, Hong had sent 2 envoys secretly and by the time they reached the Qing Songshan and Jinzhou had already fallen. Nonetheless the talks occurred and the Qing in a great position demanded territorial concessions, 1 million taels of silver per year in tribute and would pull their troops back away from Ningyuan as a gesture of good faith. The 2 states would be made equals and exchange ministers to conclude the agreements. All of this was relayed to Chongzhen who assembled his court who were deeply divided over the matter. On one hand agreeing to this would stabilize the frontier and allow the Ming to devote all their resources to deal with the rebels. But on the other hand, it was dangerous to publicly announce that the Ming dynasty was now treating with the Qing. The court decided not to go through with it and the envoys left Shenyang, thus from that point onwards no real peace talks would occur again between the 2 dynasties. The Qing brushed this off, because now they understood how strong their position was. The conquest of the Ming dynasty was now a reality if they so desired it. Hung held a conference with his advisers who all came to the conclusion that peasant rebellion within the Ming Dynasty they had all had reports of could do much of the heavy lifting. Hung would continue his raids to plunder more supplies and booty, but he also ordered his men not to rape or plunder indiscriminately. In september of 1642, the Qing sent 50,000 troops hitting Ming defenses along the Great wall, winning a series of minor battles. Then they assaulted Dongchang but were repulsed by its defenders led by Liu Zeing. Despite the minor setback, they would eventually capture Dongchang 3 months later. It turned out the defenses of places in Shandong were oriented towards the sea and the defenders were equipped and trained to counter attacks from that direction, thus they were not as prepared for cavalry attacks. The Qing then attacked Jining, where Prince Lu courageously led the defense, but the city soon fell and Prince Lu commited suicide. Ming Grand secretary Zhou Yanru then told the emperor he would lead relief troops himself. He did, and they routed quickly and were defeated, though he would send reports back to Beijing stating he had won a great victory. Zhou also had not been in the actual battlefield, but rather dining at banquets with friends while simultaneously sending a stream of victory reports to the Ming court. He was not alone in this, many other Ming officials were lying or over exaggerating their war efforts, not wanting to face the wrath of the Emperor's temper. During the raids into Nan Zhili, Shandong and Henan in 1642-1643 the Ming records estimated the Qing had attacked 3 superior prefectures, 18 regular prefectures, 67 counties and 88 towns. They had captured almost 400,000 people, 321,000 livestock, 12,000 taels of gold and 2.2 million taels of silver, a colossal sum. Alongside all of this they of course got their hands on more firearms. Matters were even worse than the plundering however, as the Qing raided more and more starving refugees fled into Shandong and Liaodong burdening local officials. Just about nothing the Ming did could hinder the Qing, until one thing put a dent in the Qing attacks, Hung Taiji died in August of 1643. Historians think it was a stroke that killed the great ruler. On the rebel front, in October of 1642, the great city of Kaifeng in Henan, once a former capital of China was completely destroyed by a man-made flood. The flood submerged the city and its estimated 80% of its population died, over 370,000 people. This would be a setback not only for the Ming, but also for Li Zicheng who had hoped to use its capture as a springboard for his ultimate goal, a thrust at Beijing. After the capture of Luoyang, Li had grown more aware of the necessity for a strategic base of operations so he could hit the capital. Kaifeng was not just a strategic place it also was a symbolic one, as mentioned it was a previous capital. Li Zichengs forces had actually assaulted Kaifeng a few times between 1641-1642, but each time they were repulsed and decided to attack other cities and return. By mid july of 1642, famine was spreading with Kaifeng and Li's forces had returned to try again. They expanded defensive moats around the city to siege and wait them out. Then they got the bright idea of utilizing the Yellow River to flood out the defenders. On july 29th, an impatient Li Zicheng killed a subordinate who proposed the idea of using the river, as his efforts to do so had not yet worked. The moats had only filled up with 5 inches of water. Then on August the 10th, the defenders of the city burst out to try and make a decisive victory against the rebels. The battle was ferocious and Li Zicheng fought in the very thick of it pushing the defenders back into the city. Kaifengs walls were beginning to crumble, food was scarce and no relief armies were able to come to its aid. The usual reports of people resorting to cannibalism began, thus things were quite dire. This got the defenders to think of anyway to escape this plight, one idea was to use the river. Water levels had risen to around 4 feet deep and heavy rains were adding to this. The defenders hoped that by diverting the river, it might provide them with fish and other food sources. The commander of kaifeng in desperation sent 3000 of his best troops out in the middle of the night to cut the dikes, but his men were caught and turned back. Then in the middle of the night on october 7th, the defenders were awakened by a great roar and the river suddenly came crashing right into the city. The rebels pulled back and watched the enormous power of the river doing all the work for them. Historians are not 100% sure if the rebels had ultimately cut down the dikes or perhaps heavy rains simply collapsed them. But in any case, the river smashed through the Cao gate in the north, sweeping everything before it and rushed out the south gate. People desperately climbed towers to avoid the raging waters or made rafts. The commander of the city built some 20 boats to evacuate, Prince Zhou and other high officials, as most commoners were forced to cling to tree branches and debris praying for rescue.By dawn of october 10th, the city was fully submerged. The rebels looted what was left of the city, but it was in such a sorry state there was no point trying to occupy it as a base of operations. Thus a disappointed Li Zicheng turned further south. It was a catastrophe for the Ming, Kaifeng was a base of operations used to coordinate defensive efforts for all of Henan and specifically to protect the southern approach to Beijing. Now as Li Zichengs forces moved south, also in august of 1642, Zhang Xianzhong was embarking on a new venture. His force had been camped in Lake Chao not too far from Luzhou where he began to recruit and train a naval force. Zhang planned to attack Nanjing via the Yangtze river. For Li Zicheng, he was turning his attention towards Nanyang where Sun Chuanting was leading Ming troops. Li and Sun's forces clashed a few times, but Li was able to bait, ambush and eventually force Sun's forces to retreat towards Shaanxi and the Tong Pass. This allowed Li to hit the last position of Ming strength left in Henan, Runing. Runing was defended by commander Yang Wenyue with only 3000 troops. Yang also happened to be an old rival of Li's who had fought him a few times outside Kaifeng. As soon as the rebels approached the city, the defenders began to break and fled. Apparently the defenders threw corpses over their walls into the moat in desperation. When Li Zicheng entered the city he faced the captured Yang and said to him “Master is an important official of the dynasty who will not submit to us. But now that we've caught you, what is your wish?” Yang replied “I myself, without any soldiers, only want to kill you. So today I'll die at you hands. What else can I say?”.Yang was then executed in front of the Sanyi temple. Li Zicheng followed this all up by taking Xiangyang, De'an and Chentian in early 1643. At Xiangyang, Li took new steps to building up his new order. He took the residence of Prince Xiang and made the prince and his siblings earls. Prince Xiangyang was renamed Xiangjing and Li took the title of “Long Accumulated Worshiping Heaven Leading-in-Righteousness Generalissimo”, and thank god he decided to shorten that all down to commander in chief. His secondhand man, Luo Rucai took the title “generalissimo whose virtue and awe pacifies the people on behalf of heaven”, what is with these guys and these ridiculously long titles? At this point Li Zichengs force began taking all men they captured between the ages of 15-40 and enrolled them in the army, and soon they were a goliath 600,000 man strong force. A few months later, Li Zicheng adopted the title of Prince of Xinshun and began procedures for taking future cities. Now if defenders resisted for 1 day, 30% of them would be killed, if resistance lasted 2 days, 70% would be killed and if after 3 days all would die. When Chongzhen heard reports about this he was utterly disgusted. Zhang Xianzhong also upted his anty by renaming and reclassifying captured towns and prefectures in Central China even when he did even not hold them. To add to the Ming's misery, some of Zuo Lingyu's subordinates attempted a mutiny to take Nanjing, raising a ton of tension. Zuo was eventually able to quell the mutiny, but it distracted him and his forces from Zhang's operations. At the beginning of 1643, Zhang remained the only rebel leader not directly subordinate to Li Zicheng. Zhang knew the danger posed by this and started to consolidate and legitimize his own power lest he be swallowed up by Li. Thus Zhang decided to attack Nanjing and as we mentioned he built some naval power to do so. In may Zhang's force moved into eastern Huguang capturing several cities and he soon renamed himself Prince of Xin Shun. Then Zhang targeted the capital of Huguang, Wuchang. Many of Wuchangs forces were former mutineers under Zuo Lingyu's. The city's defenses did not fare too well to say the least and fell by July the 15th. In the chaos of its capture, thousands were massacred by Zhang's men and thousands more drowning in the local river. Prince of Chu himself was drowned in a bamboo cage by Zhang's orders. The river was allegedly so full of corpses that the fish were unfit for consumption months after. Zhang took all the captured men between 15-20 enrolled them as soldiers and killed the rest in quite a grisly manner. He renamed the city Tianshoufu meaning “received from heaven” and the capital of his new Western Kingdom. Zhang then elevated the late Prince Chu's younger brother to a position of nobility within his new order. Zhang went on to make all these proclamations and promises of restructuring so much, but he only really ended up occupying the city for barely a month before being chased off by Zuo Liangyu. As he withdrew he torched the city, I guess so long for all that? When Li Zicheng got report of all these ongoings he decided to place 1000 taels for Zhang's head, demonstrating the emerging rivalry. Zhang moved on to occupy Yezhou then used his boats to strike at Changsha. Like the poor souls of Wuchang, the defenders of Changsha did not take notice of the incoming rebel force and did not make any strong defensive points along the city's northern approach. When Zhang approached the city's gates he demanded their surrender and a brief effort was made by the defenders to repel them. Knowing it was fruitless, the commander of Changsha asked if he could give his life in return for the sparing of the people. Zhang accepted this, it is said the commander's eyes remained clear and bright and he did not cry out as he was cut to pieces. The Ming Court was feeling helpless towards the declining situation, now both the frontier and interior were in utter chaos. Officials were being impeached left right and center and some executed. More and more officials poured into the imperial palace as the Emperor demanded solutions. In spring of 1643, Li Zicheng began to consolidate his movement by eliminating rival subordinates. The first to go was Ge Guoyan after he secretly met with Luo Rucai which prompted suspicion from Li. Li then invited Ge to a banquet, got him very drunk and killed him, thus taking all of Ge's forces as his own. Subordinates Zuo Jinwang and He Yilong were dispersed, in a similar fashion. And even Luo Rucai would face elimination, it seems he had grown to popular despite the fact, unlike Zhang he never expanded his political goals and prefered the life of a wandering bandit. There is some evidence to suggest Li took out Luo because rumor had it the Ming were trying to get Luo to kill Li and defect. Luo did not fall for the banquet affair, but later would be killed by a death squad sent by Li whom caught Luo asleep with his forces in camp. Luo's forces would be taken by Li who continued his purge, which prompted some subordinates to defect to the Ming. The great purging did not go unnoticed prompting Zhang to send Li gifts, probably hoping to get on his good side, but Li sent nothing in return. In autumn of 1643, the Ming made a large offensive against Li Zicheng. The emperor ordered Sun Chuanting to conduct an operation in Henan towards the east to crush Li once and for all. The problem for a long time though was most military strength was in the northeast thwarting off the Qing, but now it seems the court decided to divert considerable resources from the northeast in the hopes of destroying Li Zicheng in Henan. Sun Chuanting was not loved by the local gentry in Shaanxi because he raised many taxes to pay for local defenses, despite them being successful. These gentry thought if they allowed Sun to lead Ming armies away from his defensive positions, he would no longer bother them with more taxation, so they supported the idea. Sun opposed the operation for many reasons, firstmost he thought his defensive plans were bearing fruit in Shaanxi. If Li's army swelled, their supply lines would become problematic and with winter on everyone's heels, Sun figured Li's army's morale would eventually break and they would have to go west, falling upon Sun's defenses. Sun was also concerned with supplying his force in the event of an offensive operation as in the past this proved to be fatal. He advised waiting until the following spring, but was completely ignored as all the gentry were now pushing for the operation. Sun eventually had to bow to local gentry and court pressures to lead the offensive, remarking “this is the path to ruin” as he did so. Sun marched down the yellow river valley gathering Ming remnant forces in Luoyang. Sun then ordered Zuo Liangyu to take a force and advance from Jiangxi and strike south upon Runing, hoping they could perform a pincer attack. However Zuo's force was still recovering from being smashed the year earlier and had to refuse this order, something increasingly being done by commanders in the field. So Sun had to advance alone and managed to smash a rebel force at Ruzhou to the utter delight of the Ming court. They were all jubilant, except for the Vice minister of War, Zhng Fengyi who reminded them the rebels might be feinting an illusion of weakness to lure Sun into a trap. Well Sun soon won victories at Baofeng and Jia pushing the rebels further towards Xiangcheng. Despite the victories, Sun was facing the very problems he had foreseen. His troops were running low on supplies, and years upon years of scorched earth tactics had devastated the agriculture of Henan. Thus Sun's troops were at the mercy of neighboring provinces for food supplies but the officials in those regions were either unable or unwilling to send the provisions. At that point Sun's 2 subordinate commanders argued if they should go back on the defensive or continue with the offense. Sun had a spy within Li Zichengs camp telling him that Li force was on the ropes, thus Sun decided they would continue. As November hit, things got really bad, supplies worsened and Sun troops began to raid local towns or eat their own horses. The rearguard of his army then got cut off by forces under Li who spread rumors to them that Ming relief forces were not coming to their aid. This all panicked the men and the rear began to rout. Upon seeing the chaos, Sun ordered a general retreat and told his subordinates Gao Jie to protect their rear and for Bai Guang'en to lay ambushes to cover the retreat. Bai took his forces and simply bolted for the Tong Pass. Unfortunately for his almost complete infantry force, do remember they began eating all their horses afterall, well Li's cavalry found them and smashed them to pieces. Sun's army was soon routed losing 40,000 men and abandoning an incredible amount of weaponry to the rebels. Sun tried to make a stand at the Tong Pass but his forces crumbled to the rebels. Bai Guang'en not only got his force smashed, but he ended up defecting to Li and became a commander for him. Sun proceeded to retreat up the Weir River valley where he would fight a final battle at Weinan and he would die with his men. Gao Jie took his remaining forces and fled north, leaving Beijing completely open to attack. All of this convinced Li that the time was ripe to declare his intent to overthrow the Ming dynasty and formally establish his own regime which would be at Xi'an. While that was going down, Zuo Liangyu was fighting Zhang Xianzhong's forces further south. Although Zuo's men managed to recapture Xiangyang and Nanyang, Zhang as we mentioned had taken Changsha and now fortified it. The fighting between Zuo and Zhang would continue and before long Zhang found himself setting up in Sichuan where he established his Great Kingdom of the West. It was there as I mentioned that he took Yang Sichang's corpse and desecrated it. Back in Beijing, the court now made Yu Yingui supreme commander of Shaanxi. And Yu was very skeptical about any effort to turn the tide at this point, well no duh. With Sun Chuanting dead, Li Zicheng had several options laid bare to him. One of his subordinates advised him to take Hebei's capital next, another said they should loop around Jinling to get supplies and hit Beijing, others suggested taking a position in Henan and capturing further cities to draw more troops then go across Shanxi to hit Beijing. In the end Li liked the last plan which was advised by his subordinate Gu Junen. Yet before Li would set out to do all of this he wanted to create his own administration in Xi'an. He also decided the attack on Beijing would be done from 2 directions. Li and his subordinate Liu Zongmin would advance on Beijing from the northwest, first heading from Xi'an and seizing Ming garrisons along the way through Shaanxi and the Great Wall at Juyong pass. His other subordinate Liu Fanglian would advance from the south, crossing through Henan to hit Beijing. Xi'an was protected by some of the largest walls in all of China and would fall without a single fight as one of its leading officials was working with the rebels. At Xi'an Li made the Prince of Qin an administrator and renamed the city Chang'an, recalling its Tang dynasty name. Li followed this up by adopting many Tang Dynasty names for office positions and cities to add legitimacy to his own name and movement. Li also began wearing dragon robes and began to distribute wealth to the people. Li's armies fanned out and conquered numerous places renaming them. One place they took was his hometown of Mizhi which he renamed Tianbao “protected by Heaven” and he began to construct a palace there. On New Years day of 1644, Li Zicheng declared his rival Shun Dynasty within the city of Xi'an, now called Chang'an. Li took the reign title, Yongchang meaning “eternal prosperity”. Li then attacked the last remaining Ming stronghold in Shaanxi, that of Yulin. The fighting was fierce, but Li's cannons broke its walls. Next to fall was Ningxia, and Qingyang where Liu Zongmin suffered an astounding 30,000 casualties but took the city. Guyuan was handed over to Bai Guang'en without a fight and soon the rebels were marching towards Gansu. Meanwhile Beijing was in full panic, some even advising a retreat to the second capital of Nanjing. In response to Li's march, the court dispatched commanders to various routes going to the capital to hinder Li. Li Mingrui the Hanlin Academy lecturer advised the emperor in front of the court that he should have a quote “southern tour to Nanjing wherein by virtue of the monarch leaving the capital like a dragon rising or a tiger leaping the masses would spontaneously rise to quell the rebels”. Emperor Chongzhen made no note of this at court, but in private told Li he agreed but feared what would befall the Ming subjects if they learnt the Emperor was fleeing to Nanjing. They then secretly went over the logistics of how to get the Emperor to Nanjing safely. Li suggested taking men from the 8 prefectures around the capital rather than any from the northeast which would look like they are abandoning territory to the Qing. In the midst of these plans another advisor came forward, Grand Secretary Li Jiantai who argued they should raise 1 million taels of silver to recruit and fund an army to take Shanxi back. The Emperor pressed him on this and Li stated he would work with the scholar Shi Long to gather supporters from all over the northwest. The Emperor in absolute desperation liked this plan and gave the go, giving Li the double edged sword of authority. It is claimed the force that was sent out was 100,000 strong. The problem was all these men was that they were in the words of a modern scholar “dandies, spoiled rich kids, space fillers and incompetents”. Around half the force deserted after marching only 30 miles and returned to Beijing. Before any serious fighting ever occurred most of the force simply scattered. Just 3 days after the army left Beijing, the Emperor asked his Minister of War about Li's whereabouts and the official had no idea prompting Chongzhen to exclaim “how can my Minister of War not know this?”. At this point the Emperor sat down with an official to look at the numbers. The officials told him the rebels claimed to have a 1 million man strong army, but reassured him it was probably around 100,000. Then he gave the emperor a sobering account that the Ming forces around Beijing were around 80,000 strong, but only around 30,000 of them could be somewhat trusted and of that only 3000 really trusted. It was at this point the emperor revisited the southern tour idea in private while putting on a face in public that he would not leave Beijing. News from the front indicated Shun forces had just captured Taiyuan and Datong where they killed another Ming prince. Then the Shun took Xuanfu whose defenders simply turned the city over and the populace welcomed the Shun with cheers and burning incense. Then Changping fell in March without much of a fight. When the Emperor received news of Changping's capture he got up during a court meeting and simply walked out. It is alleged he paced around the forbidden city screaming out “my minister have failed me! Failed me!”. Li Zicheng sent envoys to Beijing asking for the city to be handed over without a fight and offering a deal with the emperor whereby he would be recognized as a prince and together they would face the Qing. This offer would mean that Li would be formally be made a Prince of Shun and all territory in the northwest would be his. Second the Shun would receive a tribute of 1 million taels. Third the Shun would not take orders from Chongzhen, but would help fight the Qing and assist in quelling other rebels. Emperor Chongzhen did not accept the proposal. Chongzhen ordered many of his children to flee south and issued a directive for all his civil officials to kill themselves since they had failed to save the dynasty. When the rebels began to attack the gates of Beijing, the defenders fired powder shots as they had all reached an agreement with rebel agents. Li Zicheng made great efforts to break the will of the defenders at Beijing before his approach. On the afternoon of April the 24th, one of Emperor Chongzhen's eunuchs gave the orders to open the city gates. Li promised the people of Beijing amnesty to all those who surrendered. Emperor Chongzhen appointed Liu Wenbing in charge of rallying the populace to defend the city to which Liu replied “If your majesty cannot do it, then how can I?”. The Emperor then went to the Qianqing palace in the forbidden city and told the empress “All is lost. As you are the Mother of All Under Heaven, you should die” she replied “I have followed your highness for 18 years and I will die without a word; today we die together with the altars of state and we will have no more regrets”. The emperor ordered the royal family remaining in Beijing to commit suicide and for the younger ones to try and escape. The empress and many other members were able to commit suicide, but Chongzhens youngest daughter Zhaowang he had to kill himself with a sword. Allegedly, Chongzhen by this point was so utterly drunk, he accidentally cut Zhaowang's arm off in the process and left her to die in a pool of her own blood. It is also furthermore rumored she would survive the wound and would live out the rest of her life as a buddhist nun. Chongzhen and his faithful eunuch servant, Wang Cheng'en went to the base of Coal Hill and hung themselves from a tree. The Emperor left a suicide note reading in part “My inadequate virtues and weak flesh have invited punishment from Heaven. Now the treacherous rebels are invading the capital. My officials have caused all this! I must die but I am ashamed to face my ancestors. Therefore I take off my crown and cover my face with my hair. Rebels! You can dismember my body, but do not harm the common people!”. As the Emperor lay dead, several eunuchs of the Ming Court, alongside the Minister of War, Zhang Jinyan welcomed Li Zicheng into the city. Li Zicheng initially prohibited his men from plundering Beijing, but it was not too long until the populace was subjected to rape and looting. Afterall how could Li Zicheng stop his men from the ultimate prize that was Beijing. The Shun Dynasty was beginning to be established, but unfortunately for Li Zicheng there loomed a rather large problem at hand. That problem was in the form of the Qing empires forces at the doorstep of the now dead Ming dynasty. Li Zicheng had a major problem, the Qing had bided their time waiting for a moment to strike and it was coming any minute now. Li Zicheng's only hope to hold them off would be to try and rush to the northeast and win over as many of the Ming defenders in the area as possible and bolster them up. In May Li Zicheng had to set forth from Beijing to meet the enemy in the northeast, leaving his subordinate Niu Jinxing in command of Beijing. Over in Shanhaiguan was commander Wu Sangui who was very unsure what to do. Then Wu learnt that the forces of Li Zicheng had abused members of his family back home and decided he would defect to the Qing. Li Zicheng heard reports of Wu's resolve and begrudgingly sent a small force quickly to attack Wu who engaged that said force around Yongping. Wu smashed the force to pieces and fled back to Shanhaiguan. Now enraged, Li and Liu went forth with an army of around 100,000 to crush Wu. Now Wu realized the Qing military were most likely better off than the rebels and after some lengthy negotiations with Prince Dorgon, Wu arranged to allow the Qing to enter China proper through Shanhaiguan unmolested in exchange for their assistance in defeating the treacherous Li Zicheng. It seems Wu believed he might be able to score himself as the next ruler of the Ming state or atleast become a Prince under the Qing. Dorgon was quite suspicious of Wu however. The offer suited the Qing of course, it would allow them to look like they were avenging the Ming Dynasty against the rebels. Before Wu had come forward, Dorgon had been planning an attack on Beijing by coming through inner mongolia, but now the alliance solved that problem entirely. A Qing force of 140,000 came to Shanhaiguan and joined forces with Wu's. Dorgon ordered Wu to take his army as a vanguard for their combined force. Dorgon's thinking was by doing so Wu's men would take the brunt of the hard fighting and this would ensure after their victory that his forces would not be strong enough to stand up to them if he had a change of heart. Li Zicheng had set out with 100,000 men, but many of his commanders were recent turncoats such as Tang Tong and Bai Guang'en. Also for many of the rebels, the ultimate goal had been achieved, they looted Beijing, many did not have the mind to continue fighting. Li Zicheng's ultimate mistake however was not that he was engaging in combat with Wu or the Qing, but that it never occurred to him that they would join forces. In late May the Wu/Qing and Shun forces would do battle on a field just outside Shanhaiguan. Shanhaiguan had 3 outlying castles guarding the interior approach and Wu had prepared his main defensive line at the west bank of Shihe. 40,000 Shun troops crashed into Wu's main defensive line and Wu motioned his forces back into the main castle while simultaneously sending 20,000 men to the north and west to cut off the Shun's escape routes. In the initial clashes the battle was fairly even, with both Wu and the Shun losing considerable amounts of men. Wu grew concerned that the Qing were merely going to allow his force to be smashed to pieces and then sweep in afterwards, and he had every right to think this, they most likely were doing just that. Despite the odds, Wu's force seemed to be turning the tide somewhat and this prompted Dorgon to send 2 waves of 20,000 cavalry to envelop the Shun. The next day, Wu led a charge against the Shun formation but they repulsed him right back into the castle pass. Then the Qing cavalry of the White banner led by Ajige and Dodo smashed into the Shun. Wu's men saw the Shun morale crumble and charged upon them again, bursting out of the castle. Li Zicheng was directing the battle from a high tower position and upon seeing the cavalry, he simply assumed them to be Wu's forces. dust clouds made by the charging cavalry made it very hard to see what was going on, but as the battle heated up more, Li began to see swarms of arrows raining down on his men and he realized these were Manchu people, he screamed out “the tartars have come!”. The Shun force collapsed, many were driven towards the sea and drowned. The Shun force retreated scattered, with many running back to Beijing. Li and his forces then fled as fast as they could for Beijing where they staged a very quick enthronement ceremony for Li where as he declared himself emperor. Then Li and his army plundered Beijing and most of the rebel left the city the day after, carrying off their loot. Prince Dorgon, serving as a regent for the child Emperor of the Qing, Shunzhi, entered Beijing in May of 1644 seeing all the rebel armies flee before his men. He announced to the populace they were now under Qing rule as Li Zicheng fled west to Xi'an. Over the next 6 months, Li's authority would disintegrate throughout all the territories he had conquered. Ming loyalists, some semi-independent warlords and the Qing swallowed up everything in sight. Eventually Li found himself in the summer of 1645 being pursued by the Qing prince Ajige to the vicinity of Mount Jiugong. How Li died is not exactly known, some say he hung himself after being surrounded by some angry peasants. Others say peasants beat him to death looking for food. What is known is that his corpse was badly mutilated when it was found. Li Zichengs body was sent south to Ming authorities who decaptitied it. Our old friend Zhang Xianzhong was in Sichuan and would hold out until 1647. Ming loyalists in the south would hold out on the mainland until 1662, ironically many of Zhang Xianzhong's subordinates would be their commanders. Some Ming loyalists famously would hold out in Taiwan until 1683 still trying to reclaim the dragon throne for the Ming. History marks the fall of the Ming dynasty to be in 1644 with the death of Emperor Chongzhen. Many historians argue various reasons for why the Ming Dynasty ultimately fell. One history stated quote “could no longer manage its resources, utilize its strengths, and maintain its focus.”. And indeed the Ming Dynasty fell as a result of gradual political, strategic and tactical errors that simply grew so large they could not be overcome. Given proper leadership, delegation of authority and allocation of resources, the Ming Dynasty most likely could have survived. The fall of the Ming dynasty has captivated people for centuries, for it was one of the wealthiest, most powerful and prosperous empire in the world, yet it fell to peasant rebels and some unified tribal peoples of the steppe, how? As is seen with most of China's history, the fall of the Ming is seen in terms of a dynastic cycle, whereby a dynasty eventually becomes so corrupt it simply collapses upon itself and another more diligent government thats over. It is of course not as so simple as that as any of you who lasted this long can already imagine. There are various reasons for its downfall. Take for example the unbelievable factionalism of the Ming bureaucracy which in turn politicized just about every aspect of the government. By the end of its rule it certainly seemed the politics were trumping the military when it came to defending themselves. Then these problems were only made worse when more and more competent officials were jailed or executed and more and more incompetent officials were the only ones left to fill roles. The last emperor Chongzhen certainly did not make things any easier, such as when he forced Sun Chuanting to go out into the field against Li Zicheng. Also the issue of climate was striking, during the 17th century the world was witnessing what we call the last of the little ice ages. The era was marked by less solar activity and tons of volcanic eruptions that shot into the atmosphere darkened the skies. The global temperatures got cooler by around 1.-2 degrees right around 1640 in the midst of many violent upheavals. Hell remember that story about the island of Juehua being attacked because the waters had frozen allowing Nurhaci's men to cross them? It was much to the shock of the defenders and for good reason, sometimes climate can have an incredible effect on such events. The amount of natural disasters and droughts which led to wide scale famines had an enormous effect on producing the sort of situation that allowed such a large rebellion to take place. Personally having studied quite a bit about the Taiping Rebellion that will occur in the 19th century, its all quite fascinatingly similar. And trust me the fall of the Ming dynasty is quite foreshadowing. I would like to take this time to remind you all that this podcast is only made possible through the efforts of Kings and Generals over at Youtube. Please go subscribe to Kings and Generals over at Youtube and to continue helping us produce this content please check out www.patreon.com/kingsandgenerals. If you are still hungry after that, give my personal channel a look over at The Pacific War Channel at Youtube, it would mean a lot to me. So at long last the Ming dynasty has fallen and now we have the Qing dynasty taking its seat upon the dragon throne. I thought it to be very important to explain how the Ming fell, because in many ways it will mirror how the next dynasty will fall. Stating that the Qing dynasty certainly took note of what befell the Ming and made their primary endeavor to root out corruption. But ironically it would be just that which would destroy them as well.
In this episode, parents Leeza Broome and Courtney Bruce share why arthritis-specific summer camps have been such a lifeline to their families over the years. As volunteers, they helped start the very first Pacific Northwest family camp for kids with arthritis, “KAT-Fish Camp,” which has historically been put on by the Arthritis Foundation. Cheryl also shares her experiences volunteering at the camp. All three speakers share their favorite camp memories from the last two decades and explore the importance of community and belonging in chronic illness communities.Episode at a glance:Diagnosis story: Courtney shares her daughter's diagnosis story at 18 months, which started with a swollen knee and a misdiagnosis.Diagnosis story: Leeza shares her son's diagnosis story, which started with difficulty getting out of the toddler bed and swollen fingers.Why is it important to have family camps for kids with juvenile idiopathic arthritis? Leeza and Courtney share what they've learned in the parent education sessions, from advocacy to emotional tips for coping with injecting a child who's afraid of needles. Cheryl, Leeza and Courtney explore the emotions that parents, children with JIA and siblings experience at these camps including: relief, shared anger at similar negative experiences people have gone through, envy, hope and more.Favorite camp memories: all three speakers share their favorite memories, from S'Mores and campfire songs to talent shows.Where can you sign up to volunteer at a camp or attend one? Links below!Medical disclaimer:All content found on Arthritis Life public channels was created for generalized informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment.Episode SponsorsRheum to THRIVE, a community support & education program Cheryl created to help people with rheumatic disease go from overwhelmed, confused and alone to confident, supported and connected. Join the waitlist for the next group, which starts in September 2022!Rheumatoid Arthritis Roadmap, a self-paced online course Cheryl created that teaches you how to confidently manage your physical, social and emotional life with rheumatoid arthritis.Full Episode Details, Links plus Transcript:Go to the show page on the Arthritis Life website.
(episode also on my youtube channel, like and subscribe lololol! https://www.youtube.com/channel/UCn_xTpd4lFbYzEU3jzKNyOQ)New a guy in his room #111 (w/ Jia Din)! I have Jia on again (she was on before, she's a standup comic I know from the Philadelphia/Delaware area) and we talk about work offices, the reality of living in cities, and more. And also fyi, sorry about the audio in the 2nd half to the end of this episode, I had a few technical issues and almost didn't have this episode save at all. I do have new equipment now so f*** off!Topics:Intro!Open mics sucking,Standup,Maria Bamford,Writing other than standup,Making it from YouTube or show pilots,Jobs and coworkers into their job,Going into the office vs being remote,Office people making bad jokes,Other podcasts,Voice changing,Jimmy Carr,Ari shaffir Kobe and edgy comedy,Louie cks movie being canceled when he was,Hearing about Louie's allegations,Musicians vs comedians me too stuff,renting vs actually owning a home,NYC's romantic perception vs reality of living hereDC/Philly vs NYC
Recently, ACR released two treatment guidelines for JIA. One updating pharmacologic management and another for non-pharmacologic therapies. We have lead author, Dr. Karen Onel, taking us through a deep dive on these, in an episode close to Jon's heart
AiArthritis Voices 360 Podcast
In this revisit to the table (Step 5 in our problem-solving process), Tiffany, Katie, Effie, Eileen, and Kerry discuss the many layers around the word “arthritis” including: 1) Misunderstandings around the word that can lead to delays in diagnosis, family and friend judgements, and the different type associated with “AUTO” diseases; and 2) Complexities that exist when trying to identify the AiArthritis from other potential comorbidities (Osteoarthritis, bursitis, enthesitis) and how clarity about this could help with detection, access to the right treatments, and overall better health outcomes. This conversation takes many turns, all which address issues identified from lived patient experience. Why is differentiating arthritis types important? How many of us referenced family history to expedite diagnosis? How does public, family, and even doctor misunderstanding of our diseases play into diagnosis and exploring potential comorbidities? How accurate is the literature in regards to arthritis prevalence in comparison to what patients report to be true? They even started brainstorming the development of a new tool that could help the public, patients, and health providers better understand the layers of our diseases as well improve communication and overall disease journeys. Now it's YOUR turn to weigh in! There's a lot to talk about, join us ‘at the table' so, together, we can change the stories of tomorrow! Submit your comments here, at email@example.com, on our social platforms at Facebook, Instagram, Twitter, or LinkedIn @IFAiArthritis. Show Notes: 00:53 Tiffany (CEO, non-radiographic axial spondylitis) introduces the show and co-hosts, Katie (Programs & Communications Manager, rheumatoid arthritis), Eileen (“Chronic Eileen” rheumatoid arthritis), Effie (“Rising Above RA”, rheumatoid arthritis), and Kerry (“Float Like a Buttahfly”, sarcoidosis). 3:13 Tiffany officially welcomes Elieen and Kerry as the newest recurring Co-Hosts! 3:37 Explains a new addition to the show - the “360its!”, where any topic or comment from the episode is eligible to spin off into different conversations in any communication format (facebook live, twitter, 4:37 Topic is around the word arthritis, as a Step 5 (revisit to the table) issue, because in the US it's Arthritis Awareness Month and May 20th is World AUTOimmune & AUTOinflammatory Arthritis Day 6:35 Co-hosts start the conversation by answering the question, “Why do YOU think the type of arthritis associated with our diseases - and differentiating it from other types - is so important?” All co-hosts share their stories and perspectives. 11:17 In the stories shared, the co-hosts outline a journey from “What's wrong with me?” to “Misunderstandings” to “public education” and “doctor education” and “overlap of types of arthritis (also Osteoarthritis) or other comorbidities.” If we (patients, public, families, doctors) better understood arthritis and the types we could improve detection, referrals, diagnosis and, in turn, improve quality of life, increase rates of remission, and lessen unnecessary disability. This can lead to better overall healthcare and improved costs for healthcare systems. 12:52 Tiffany opens the conversation to discuss anyone's experience with relatives having our diseases. Did anyone say, “Did you have a history of autoimmune/autoinflammatory disease in your family and, if so, did anyone say to you when figuring out what was going on with you, ‘Hey, this person has XYZ, maybe you have something in that family?” They continue discussing this and determine in their cases the connection between family history and detection/diagnosis was not common. This is an opportunity to discuss further because family history and communication about it could expedite diagnosis. 17:18 Kerry puts this perspective on the table - Not all families talk about things like illness, so in those cases knowing family history is hard. But given we know AiArthritis diseases are part genetic, this could be a key factor that could either lead to quicker diagnosis, or prolong diagnosis. 18:16 Kerry - Talking about the statement “It's all in your head” - “Once I had something visible - rash on my legs, swelling - I could say ‘I'm not making this up!” Bloodwork was fairly normal except a positive test for autoimmune thyroid, which led to a sign of diagnosis. But it took the visible plus some type of autoimmune direction in bloodwork to get there. Most agree, they only realized other family members had something similar after diagnosis. Could this be in part also because it's not understood by families that ANY of out 100+ “AUTO” diseases counts as family history? Tiffany explains the importance also of knowing family history, as newer research is moving towards prevention - or at least catching the disease very early - based on certain biomarkers + known environmental triggers + family history. 21: 12 Conversation continues about family history when it comes to the doctor visit (not asked). Often this leads back to the patient trying to push testing and googling what they have. 22:37 Group starts discussing delay in diagnosis journeys, including overlap of symptoms and the arthritic component, and how important the right diagnosis matters. A lot of delay in diagnosis for Kerry came from the doctors not understanding so self advocacy became necessary to help them figure it out. When you have a rare disease, less knowledge is often present and, therefore, more self advocacy necessary. 28:48 Effie revisits the topic of family history and how culture and heritage can impact conversation (“We don't talk about family illness.”). Or, in her case, as immigrants, a lot wasn't documented. This has, in part, encouraged her to start sharing her story to help others have those ah-ha moments. 31:11 There are different kinds of arthritis and some of us have more than one, which can lead to confusion in diagnosis (“You're too young to have arthritis”, “You're too old to have RA”) and family misunderstandings (“oh I have that too, it's not that bad”). They discuss why it's important for patients to know which type they have - or if they have more than one type. Also, how do we differentiate the systemic systems (part of our disease or comorbidity?) How does it overlap or is it separate? Is there a way to treat one differently than another and, if so, what should I know? How do I identify where my pain is coming from and what am I doing to trigger this pain - did my meds stop working or is this something new? Also, since our diseases are systemic and affect organs, too - that plays into this as well. 39:05 This is a Step 5 episode, which means we have discussed these topics enough over the last year, including in this episode, to be at a point where we can head into Step 6 - which is creating a solution. In this case, a resource to help with identifying AUTO + Arthritis (and potential comorbidities) so we can improve detection, diagnosis, and disease management. Things to consider in developing this tool: Name your pain. What kind of pain do I have? (joint, enthesitis, non-joint, fibro pain, bursitis pain?) Where is it located? (Symptom chart) What disease do I have? How can this resource be used to share with doctor? Make it patient-led, then doctors review. Potential comorbidities Include building vocabulary and considerate of families/juveniles 42:50 Group discusses why this tool is also important - often doctors will not connect the dots on their own. Kerry gives an example of a doctor considering pituitary gland involvement because, “That could cover many varied issues.” It's THAT line of thinking, “What could cover many varied issues?” that doctors need to consider. 44:04 “Those with sarcoidosis are thought to have lung involvement so if that's missing as a first symptom it may be missed.” The prevalence of arthritis, and what doctors believe is the correct percentage, may differ from patient-reported prevalence. They give examples of Sarcoidosis. It's thought that only 30% have arthritis, but Kerry hasn't met one person without it. Recently in Still's Disease (which includes systemic JIA), research has shown about 25% of patients do not have arthritis - especially as a first symptom. Yet the diagnosis triangle for Still's taught to doctors is look for arthritis, rash, high fevers. Is arthritis part of the disease or a comorbidity? 49:45 Katie mentions pain evolves in perception and simply getting used to it over time (pain is normal). How does this play into pain reporting? How does measuring pain and personal tolerance and mindset play into this? 55:25 What if the arthritis isn't so bad and it's the AUTO features that dominate. How can we communicate this? The group also discusses the importance of not eliminating arthritis as a clinical component altogether if it is or was part of your disease. (It's important for our tool. Is it earlier in their disease, later, a later comorbidity/OA developing?) 59:05 Tiffany wraps up the show, starting by inviting the audience to weigh in on the tool we started to brainstorm about in this episode. You can submit your ideas at firstname.lastname@example.org, via messenger on social media @IFAiArthritis, social media posts about it. 1:01 Kerry, “Float Like a Buttahfly” can be found on Twitter and Instagram @ButtahflyK and on Facebook Float Like a Buttahfly; Effie Instagram and Twitter @RisingAboveRA and on YouTube RA and Myself, blog: RisingAboveRA.com; Eileen, “Chronic Eileen” can google this name and also writes for CreakyJoints, Healthline, and Arthritis Research Canada. 1:02:40 You can find AiArthritis at @IFAiArthritis on social media or on the web at aiarthritis.org/talkshow. While there please Tip the Team by giving a donation so we can continue providing this amazing resource! ___________________________________________________________________ Patient Voices and All Other Stakeholders - Join our AiArthritis Voices Program and Connect to Opportunities to Have Your Voice Counted If you are a patient, a parent of a juvenile patient, or any other stakeholder (doctor, nurse, researcher, industry representative, or other health services person) - are you ready to join the conversation? It's your turn to pull up a seat. Join our new AiArthritis Voices program, where people living with AiArthritis diseases and other stakeholders who we need 'at the table' to solve problems that impact education, advocacy, and research sign up to have a voice in our initiatives. By signing up, you'll get notified of opportunities to be more involved with this show - including submitting post-episode comments and gaining insider information on future show topics. Patients and all other stakeholders are encouraged to join so we can match you with opportunities to pull up a seat and TOGETHER - as equals - solve the problems of today and tomorrow. JOIN TODAY! AiArthritis Voices 360 is produced by the International Foundation for Autoimmune and Autoinflammatory Arthritis. Visit us on the web at www.aiarthritis.org/talkshow. Find us on Twitter, Instagram, TikTok, or Facebook (@IFAiArthritis) or email us (email@example.com). Be sure to check out our top-rated show on Feedspot!
Meaghan shares her journey growing up with juvenile idiopathic arthritis, which turned into psoriatic arthritis (PSA) in her twenties. She busts common myths about PSA and delves into the importance of advocacy, mental health, sharing our stories and more.##Episode at a glance:Meaghan's Diagnosis story / saga for JIA and then PsA: medical gaslighting, delays in care, learning to advocate for herself and moreWhat does Meggie Wish People Knew about PSA? Dispelling common misconceptionsMeggie's advocacy journey: from insurance step therapy to formal advocacyRelationships: Meggie reflects on dating with arthritis and shares how her husband supports herMeggie reflects on the importance of mental health & how being open about her diagnosis helped herWhat's it been like to share your story online? Meggie shares her story writing for Bezzy PSA from Healthline and sharing her story on social mediaMeggie's advice for newly diagnosed patientsWhere to find Meggie: Instagram: @Arthritis_Meggie Medical disclaimer:All content found on Arthritis Life public channels was created for generalized informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment.Episode SponsorsRheumatoid Arthritis Roadmap, a self-paced online course Cheryl created that teaches you how to confidently manage your physical, social and emotional life with rheumatoid arthritis. Rheum to THRIVE, a community support & education program Cheryl created to help people with rheumatic disease go from overwhelmed, confused and alone to confident, supported and connected. The next group starts in April 2022!For Full Episode Details + Transcript:Go to www.MyArthritisLife.Net
As a child and teenager growing up with juvenile idiopathic arthritis, Jen Blair often felt lonely, isolated and "broken." Fast forward to the present: Jen is a mother of three, accepts her "new normal" and has come to see herself as strong rather than broken. This episode delves into Jen's story and includes details about her different prescription treatments, how she came to embrace exercise and dietary contributions to her health, her pregnancy and parenting journey and her experiences both with working and being on disability.Episode at a glance:Jen's diagnosis story of juvenile idiopathic arthritisJen's treatment journey over the years: biologics, exercises, nutrition, serial casting (which is no longer done for JIA) and morePregnancy with JIA & RAWhat is it like being a mom of three children while living with JIA? Jen's emotional journey: as a teenager and young adult, experiences loneliness, isolation, yearning for acceptance, and feelings of being “broken.”Jen's experiences working in different environments and then going on disabilityJen's advice for people newly diagnosed with inflammatory arthritisMedical disclaimer: All content found on Arthritis Life public channels was created for generalized informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment.Episode SponsorsRheum to THRIVE, a community support & education program Cheryl created to help people with rheumatic disease go from overwhelmed, confused and alone to confident, supported and connected. Join the waitlist for the next group, which starts in September 2022!Rheumatoid Arthritis Roadmap, a self-paced online course Cheryl created that teaches you how to confidently manage your physical, social and emotional life with rheumatoid arthritis.Full Episode Details including Transcript:Go to www.MyArthritisLife.Net
In this episode of the EntreMD Podcast, Dr. Una interviews Dr. Jia Ng, a board-certified nephrologist and a clinical researcher at the Zucker School of Medicine at Hofstra/ Northwell. She is also the founder of PublishedMD, where she helps clinicians publish research papers and achieve their academic goals without the overwhelm.She gives us a behind the scenes tour of her journey as an entrepreneur.Links mentioned The EntreMD Business SchoolPublishedMDDr. Jia on YouTubeDr. Jia on LinkedIn
Beijing and Brussels have long been at odds over human rights issues and economic practices. The recent EU-China summit ended without significant breakthroughs, as the Comprehensive Agreement on Investment remains unsigned. Now, Russia's invasion of Ukraine could further jeopardize any future cooperation. How will the war in Ukraine impact China-EU relations going forward? Where does Europe stand amid ongoing U.S.-China competition? And what are the possible pathways to cooperation between China and the EU? During a live recording of the China in the World podcast, Paul Haenle spoke with Yeo Lay Hwee, director of the European Union Centre in Singapore, Jia Qingguo, professor and former dean of the School of International Studies of Peking University, and Philippe Le Corre, a nonresident senior fellow in the Europe Program at the Carnegie Endowment for International Peace. This panel is the fourth of the Carnegie Global Dialogue Series 2021-2022 and is available to be viewed on the Carnegie Endowment's website. https://carnegieendowment.org/2022/04/12/china-eu-relations-amid-ukraine-crisis-event-7859