Podcasts about this center

In this episode, our guest is Dr. Leigh Ann Ross who is the Associate Dean for Clinical Affairs at the University of Mississippi School of Pharmacy and Professor in the Department of Pharmacy Practice. She previously served as the Chair of the Department of Pharmacy Practice and currently serves as Director of the Center for Clinical and Translational Science and Research Professor in the Research Institute of Pharmaceutical Sciences at UM. Dr. Ross also works with the John D. Bower School of Population Health at the University of Mississippi Medical Center as a Professor in the Department of Population Health Science. Dr. Ross received a Bachelor of Business Administration and a Doctor of Pharmacy from Ole Miss. She completed a Primary Care Pharmacy Residency at UMMC. Since joining the faculty in 2009, Dr. Ross has led practice initiatives to implement medication management services at the Medical Center and in communities through UM's Community-Based Research Program. In addition to her work in pharmacy, Dr. Ross completed a 2-year Congressional Fellowship in the Office of U.S. Senator Thad Cochran where she served as policy advisor on health care and also worked on labor, housing, and economic development. Dr. Ross is a graduate of Leadership Mississippi and has been actively involved in professional organizations at a state and national level. She is a Past President of the Mississippi Pharmacists Association and current President- Elect of the American College of Clinical Pharmacy. Dr. Ross is passionate about leadership development and advocacy within our profession. Key points: Service - I love professional service and I feel it is important to encourage our students and early career pharmacists to be involved in professional organizations. I have worked with most all professional organizations over the last 20 years, but my current focus is as President-Elect of ACCP and member of their Board of Regents. Leadership - I am passionate about leadership development. I appreciate the mentorship provided to me in this area and have tried to incorporate this into our curriculum for both students and residents. Advocacy - I feel advocacy to move pharmacy forward is very important. I have enjoyed building on my experience as a Health Policy Fellow and working with others to better understand legislative processes and how to advocate for our profession. Practice Advancement / Community-Based Research - I had the opportunity early in my career to lead the Pharmaceutical Care Clinics at UMMC, comprised of pharmacist-run clinics and interprofessional clinics and later to work with colleagues to implement a Community-Based Research Program to implement medication management services (like those in the Pharmaceutical Care Clinics) in community pharmacy and clinic settings. Through the Community-Based Research Program, we have established a number of partnerships, such as the Mississippi State Department of Health. Research - Most recently, I worked with colleagues to establish a Center for Clinical and Translational Science in our Research Institute. This Center is structured to facilitate research across the translational spectrum from basic research to clinical trials to communities. Our community research is now housed in this Center. Guest - Leigh Ann Ross, PharmD, BCPS, FASHP, FCCP, FAPhA, FNAP Host - Hillary Blackburn, PharmD, MBA www.hillaryblackburn.com https://www.linkedin.com/in/hillary-blackburn-67a92421/ @talktoyourpharmacist for Instagram and Facebook @HillBlackburn Twitter

Western diet found to impair function of immune cells in the gut Cleveland Clinic, May 18, 2021 According to new study results, a team of researchers led by Cleveland Clinic's Thaddeus Stappenbeck, M.D., Ph.D., have found that a diet high in fat and sugar is associated with impaired intestinal immune cell function in mice. The findings, published in Cell Host & Microbe, provide novel insights into pathways linking obesity and disease-driving gut inflammation, and have implications for developing targets to treat inflammatory bowel diseases (IBD) in patients. Using data from more than 900 patients, the researchers found that elevated body mass index is associated with abnormal Paneth cells among patients with Crohn's disease and non-IBD patients. Paneth cells are a type of anti-inflammatory immune cell found in the intestines that helps to protect against microbial imbalances and infectious pathogens. Dysfunction of these cells is driven by a combination of genetic mutations and environmental factors. Dr. Stappenbeck and others have previously linked Paneth cell dysfunction to gut changes indicative of IBD in preclinical models and a subset of Crohn's disease patients from multiple cohorts around the world. "With this understanding, we set out to investigate whether diet-induced obesity--specifically caused by a diet high in fat and sugar, or a 'western diet'--is one of the environmental factors that can lead to impaired Paneth cell function," said Dr. Stappenbeck, chair of Lerner Research Institute's Department of Inflammation & Immunity. The researchers compared the effects of a western diet versus a standard diet. The team's western diet contained about 40 percent fat and an elevated level of simple carbohydrates, which better resembles the diet of an average U.S. adult than regimens prescribed in other preclinical studies. After eight weeks, the group that ate the western diet had more abnormal Paneth cells than the group that ate a standard diet. In the western diet group, other changes become apparent two months after the Paneth cell defects, including increased gut permeability, where bacteria and toxins can enter the gut and which is well-linked with chronic inflammation. Notably, however, switching to a standard diet from the western diet completely reversed the Paneth cell dysfunction. "When we started to look into large-scale datasets for the specific mechanisms that might connect the high-fat, high-sugar diet with the Paneth cell dysfunction, a secondary bile acid called deoxycholic acid caught our attention," said Dr. Stappenbeck.  Deoxycholic acid is a metabolic byproduct of intestinal bacteria. Researchers found that consuming a western diet increased the bile acid in a region of the intestines called the ileum and, as a result, increased the expression of two downstream molecules, farnesoid X receptor (FXR) and type I interferon (IFN). "For the first time, we showed how coordinated elevation of FXR and type I IFN signals in multiple cell types contribute to Paneth cell defects in response to a diet high in fat and sugar. In previous research, stimulating FXR has shown to help treat other diseases, including fatty liver disease, so we are hopeful that with additional research we can interrogate how the combination of elevated FXR and IFN signals can be targeted to help treat diet-induced gut infections and chronic inflammation." Dr. Stappenbeck also explained that while the team was interested to learn that changing the diet regimen reversed the pathological changes, more research would be needed to determine if these changes also occur in patients.     Count your blessings: Short gratitude intervention can increase academic motivation Ritsumeikan University (Japan), May 17, 2021   Because of the ongoing pandemic, lifestyles have been subjected to drastic and dynamic changes, and many work- and study-related activities are now carried out online exclusively. This, among other complex factors, has made it difficult for some people to stay focused and motivated, and psychology researchers are trying to find effective and widely applicable solutions to address such problems. In a recent study published in BMC Psychology, researchers from Ritsumeikan University and the National Institute of Information and Communications Technology (NICT), Japan, have explored a simple strategy to increase motivation in college students by nurturing a positive emotion: gratitude. Many studies have shown that even short "gratitude interventions," which are activities that increase an individual's awareness of feelings of gratitude, can have a lasting positive effect on that person's mood, satisfaction and well-being. However, based on previous studies, the available evidence on the effect of such interventions on academic motivation is inconclusive. This prompted the researchers to test the effects of a different type of gratitude intervention: daily gratitude journaling. "Our main hypothesis was that engaging in an online gratitude journal by writing down up to five things one felt grateful for each day could make students be more aware of their academic opportunities—their 'blessings'—and help them re-evaluate their motives and goals, ultimately improving their motivation," explains Dr. Norberto Eiji Nawa from NICT, first author of the study. They recruited 84 participants, all Japanese college students, and divided them into a control group and an intervention group. Over the course of two weeks, students in both groups had to evaluate aspects of their daily life through online questionnaires each day, but only the intervention group had to keep the online daily gratitude journal. At the start of the intervention and after one and two weeks, and one and three months, the participants had to complete the Academic Motivation Scale (AMS), a tried-and-tested tool for measuring different aspects of academic motivation. The results were promising; through statistical analyses, the researchers found that the gratitude intervention through daily journaling significantly increased the students' academic motivation. Most notably, this robust positive effect was not restricted only to the two-week period of the intervention, as the increased level of academic motivation was maintained even after three months. In addition, through an exploratory analysis, the researchers established that the enhancement in academic motivation was mostly driven by a decrease in "amotivation scores." Amotivation, in this context, refers to the state in which a person perceives that their own actions are irrelevant to the resulting outcomes, leading to feelings of helplessness and incompetence. Academic motivation can be one of the primary determinants of both academic achievements and satisfaction with school life, and developing widely applicable intervention strategies is critical to foster student growth. "Online interventions have the advantage of being more accessible, scalable and affordable to large portions of the population. Gathering solid evidence to support their deployment will be essential to unleash their true potential in the future," concludes Professor Noriko Yamagishi from Ritsumeikan University. It appears that the positive impact of gratitude interventions extends well beyond the already documented effects on individual well-being. This study was partly supported by a research grant from the Ritsumeikan Inamori Philosophy Research Center. This Center aims to promote multidisciplinary research on the management philosophy advocated by Dr. Kazuo Inamori, a prominent Japanese entrepreneur and renowned philanthropist. With this major goal in mind, Professor Yamagishi, alongside Dr. Nawa, have been working on the scientific elucidation of the emotions of "altruism" and "gratitude" from the perspective of cognitive psychology and neuroscience. This particular study was conducted as part of this more overarching research. Until the day these human emotions become clearer, we can safely give this piece of advice: remember to count your blessings.   How Quickly Do We Become Unfit?   Anglia Ruskin University, May 14, 2021 Getting in shape isn’t easy. But after all that hard work, how long do we actually maintain it? Turns out that even the great effort we put into training, taking a bit of time off can mean that we become “unfit” much faster than it took us to actually get in shape. To understand how the body becomes “unfit”, we first need to understand how we become fit. The key to becoming fitter – whether that’s improving cardiovascular fitness or muscular strength – is to exceed “habitual load”. This means doing more than our body is used to. The stress that this has on our body makes us adapt and become more tolerant, leading to higher fitness levels. The time it takes to get fit depends on a number of factors, including fitness levels, age, how hard you work, and even environment. But some studies do indicate that even just six sessions of interval trainingcan lead to increases in maximal oxygen uptake (V02 max) – a measure of overall fitness — and improve how efficiently our body is able to fuel itself using the sugar stored in our cells during exercise. For strength training, some gains in muscle force can be shown in as little as two weeks, but changes in muscle size won’t be seen until around 8-12 weeks. Cardiovascular fitness When we stop training, how quickly we lose fitness also depends on many factors – including the type of fitness we’re talking about (such as strength or cardiovascular fitness). As an example, let’s look at a marathon runner, who is in peak athletic fitness and can run a marathon in two hours and 30 minutes. This person spends five to six days a week training, running a total of 90km. They’ve also spent the last 15 years developing this level of fitness. Now let’s say they stopped training completely. Because the body no longer has the stresses of training forcing it to stay fit, the runner will start to lose fitness within a few weeks. Cardiorespiratory fitness – indicated by a person’s V02 max (the amount of oxygen a person can use during exericse) – will decrease around 10% in the first four weeksafter a person stops training. This rate of decline continues, but at a slower rate over longer periods. Intriguingly, though highly trained athletes (like our marathon runner) see a sharp decline in V02 max in the first four weeks, this decline eventually evens out, and they actually maintain a V02 higher than the average person’s. But for the average person, V02 max falls sharply, back to pre-training levels, in less than eight weeks.   The reason V02 max declines is due to reductions in blood and plasma volumes – which decrease by as much as 12% in the first four weeks after a person stops training. Plasma and blood volume decrease due to the lack of stress being put on our heart and muscles. Plasma volume may even decrease by around 5% within the first 48 hours of stopping training. The effect of decreased blood and plasma volume leads to less blood being pumped around the body each heart beat. But these levels only drop to where we started – meaning we won’t get worse. Of course, most of us aren’t marathon runners – but we’re also not immune to these effects. As soon as we stop exercising the body will start to lose these key cardiovascular adaptations at a very similar rate as highly trained athletes. Strength training When it comes to strength, evidence shows that in the average person, 12 weeks without training causes a significant decrease in the amount of weight we can lift. Thankfully, research shows that you maintain some of the strength you gained before you stopped training. What is intriguing is that despite the significant decrease in strength, there’s only a minimal decrease in the size of the muscle fibres. The reason we lose muscle strength largely has to do with the fact that we’re no longer putting our muscles under stress. So when we’re no longer working our muscles hard, the muscles become “lazy”, leading the number of our muscle fibres to decrease, and fewer muscles being recruited during an activity – making us less able to lift the heavy loads we used to. The number of muscle fibres used during exercise decreases by around 13% after just two weeks of no training – though this appears not to be accompanied by a decline in muscular force. This implies that the losses observed across the longer periods of detraining are a combination of both this initial decline in the number of muscle fibres we use, but also the slower decline in muscle mass. For the average gym goer who lifts weights, they would experience a drop in the size of their muscles – over time finding it harder to lift heavy loads as they have less muscle fibres being recruited. So even after all that effort to get fit, we start losing cardiovascular fitness and strength within 48 hours of stopping. But we don’t start to feel these effects for at least two to three weeks for cardiovascular fitness and around 6-10 weeks for strength. Rates of “de-training” are similar for men and women, and even for older athletes. But the fitter you are, the slower you’ll lose your gains.   Non-drug therapies as good as or better than drugs for treating depression in people with dementia St Michael’s Hospital, University of Toronto, University of Calgary May 17, 2021   Doctors should consider more "social" prescribing of non-drug approaches for depression and loneliness, say researchers Non-drug therapies, such as exercise, appear to be as, or more, effective than drugs for reducing symptoms of depression in people with dementia, suggests research published online in The BMJ. The findings suggest that people with dementia will derive a clinically meaningful benefit from non-drug interventions, and the researchers say doctors should consider more "social" prescribing of non-drug approaches to treat symptoms of depression and loneliness. Fifty million people worldwide have a diagnosis of dementia. About 16% of these people also have a diagnosed major depressive disorder, and 32% will experience symptoms of depression without a formal diagnosis. Previous trials have shown that non-drug approaches, such as exercise, alleviate symptoms of depression in people with dementia, but it's not clear how effective they are compared with drugs to reduce symptoms of depression. To address this uncertainty, researchers analysed the results of existing trials to compare the effectiveness of drug and non-drug interventions with usual care or any other intervention targeting symptoms of depression in people with dementia. After screening 22,138 records, they focused on and reviewed 256 studies involving 28,483 people with dementia, with or without a diagnosed major depressive disorder. Drug approaches alone were no more effective than usual care, but they found 10 interventions associated with a greater reduction in symptoms of depression compared with usual care. These were cognitive stimulation, exercise, reminiscence therapy (a treatment to help people with dementia remember events, people and places from their lives), cognitive stimulation with a cholinesterase inhibitor (a drug used to treat dementia), massage and touch therapy, multidisciplinary care, psychotherapy combined with reminiscence therapy and environmental modification, occupational therapy, exercise combined with social interaction and cognitive stimulation, and animal therapy. Three interventions -- massage and touch therapy, cognitive stimulation with a cholinesterase inhibitor, and cognitive stimulation combined with exercise and social interaction -- were found to be more effective than some drugs. The authors acknowledge some study limitations, such as being unable to explore severity of depression symptoms or effects on different types of dementia. Nor did they look at the potential costs or harms of implementing drug and non-drug interventions. However, notable strengths included the large number of articles reviewed and use of a recognised clinical scale for capturing symptoms of depression. As such, they say in this systematic review, "non-drug approaches were associated with a meaningful reduction in symptoms of depression in people with dementia and without a diagnosis of a major depressive disorder. And they add that everyone -- patients, caregivers, clinicians and policy makers -- have a role in translating these findings into practice     Omega-3 lowers childhood aggression in short term, Penn research shows University of Pennsylvania, May 13, 2021 Incorporating omega-3, vitamins and mineral supplements into the diets of children with extreme aggression can reduce this problem behavior in the short term, especially its more impulsive, emotional form, according to University of Pennsylvania researchers who published their findings in the Journal of Child Psychology and Psychiatry. Adrian Raine, the Richard Perry University Professor of Criminology, Psychology and Psychiatry, has spent his career looking at how the brain's biological functioning affects antisocial behavior. He focuses specifically on understanding these actions and learning how to modify them, whether with something benign like a child acting out or with something extreme, in the case of a homicidal killer. "How do you change the brain to make people better?" he asked. "How can we improve brain functioning to improve behavior?" These questions formed the foundation for work Raine had previously done with adolescents on the African island of Mauritius. In a randomized control trial, one group received omega-3 supplements for six months, the other didn't. Those taking the fish oil saw a reduction in aggressive and antisocial behavior. "That was my starting point," he said. "I was really excited about the results we published there." Mauritius, however, is a tropical climate and a different culture from the United States, so Raine, a Penn Integrates Knowledge Professor, decided to test a new version of the study in Philadelphia, to aim for more broadly applicable outcomes. He partnered with Therese Richmond, the Andrea B. Laporte Professor of Nursing and associate dean for research and innovation, and several other Penn faculty, including Rose Cheney of the Perelman School of Medicine and Jill Portnoy of the Criminology Department in the School of Arts & Sciences. The Philadelphia randomized control study placed 290 11- and 12-year-olds with a history of violence into four groups: The first received omega-3 in the form of juice, as well as multivitamins and calcium for three months. For that same duration, a second group participated in cognitive behavioral therapy, or CBT, which included meeting weekly for an hour, with time split between the child, the parent and with both together. "Sessions focused on the links between thoughts, feelings and behaviors and also practicing alternative actions the children could take to deal with difficult situations rather than to emotionally react to something," said Richmond, who supervised the clinical trial. "It's helping the child build a toolbox of ways to interact with others. For example, if I'm angry, how might I cope with anger other than physically striking out?"All participants got homework, too. A third group in the study took the supplements and participated in CBT, and a fourth received resources and information targeted at reducing aggressive behavior. Blood samples at the experiment's start and conclusion measured omega-3 levels in each child. "Immediately after three months of the nutritional intervention rich in omega-3s, we found a decrease in the children's reporting of their aggressive behavior," Richmond said. The team also followed up three and six months later. At the first check-in, participants getting the combination of CBT and omega-3s reported less aggression than the control group and the therapy-only group. By the final check-in, however, any positive effects had dissipated. What remains unknown is whether continued use of omega-3s would lead to a long-term reduction in antisocial behavior. There were other minor limitations to the research. For one, self-reporting completed by parents and children didn't line up. The 11- and 12-year-olds in the omega-3 and CBT-supplement groups noted fewer aggressive behaviors; their parents said such tendencies hadn't changed. Also, some participants dropped out before the study had finished. Despite these challenges, Raine, Richmond and their colleagues said the findings provide some important insight. "No matter what program you use, could adding omega-3s to your treatment help?" Raine asked. "This suggests it could." And though the work answers some questions, it also creates new ones, which returns to a larger point regarding the mind-action connection: It's complicated. "We can't oversimplify the complexity of antisocial behavior. There are many causes," Raine said. "It's not just the brain. Is it a piece of the jigsaw puzzle? I think it is."     Lockdown led to positive lifestyle changes in older people University of Stirling (Scotland), May 17, 2021 The COVID-19 lockdown was a catalyst for many older people to embrace technology, reconnect with friends and build new relationships with neighbours, according to University of Stirling research. Understanding the coping mechanisms adopted by some over 60s during the pandemic will play a key role in developing interventions to help tackle loneliness, isolation and wellbeing in the future. The study, led by the Faculty of Health Sciences and Sport, surveyed 1,429 participants - 84 percent (1,198) of whom were over 60 - and found many had adapted to video conferencing technology to increase online contact with existing social networks, while others reconnected with previous networks. Participants reported that lockdown had led them to engage with neighbours and other members of their communities for the first time, while several said social distancing had brought an additional meaning to life, by highlighting what was important to them. Published in the International Journal of Environmental Research and Public Health, the paper comes six months after the study - funded under the Scottish Government Chief Scientist Office's Rapid Research in COVID-19 programme - reported in its preliminary findings that social distancing had increased feelings of loneliness in older people. Professor of Behavioural Medicine, Anna Whittaker, who led the study, said: "Our research found that the COVID-19 lockdown triggered feelings of loneliness in older people - with many experiencing less social contact and support. However, the study also highlighted positive outcomes, for example, lockdown encouraged some older people to embrace and engage with technology - such as Zoom, Whatsapp or FaceTime - to stay in touch with loved-ones or participate in exercise classes or religious groups. Those who engaged in such activity were able to prevent high levels of loneliness, therefore, helping older adults to increase their digital literacy and use of remote social interactions could be a really important tool for addressing loneliness. "Participants also reported actively looking for new social contact while restrictions were in place - such as contacting friends who they had not spoken to in years and increasing interactions with neighbours and other members of their communities. Significantly, many of our participants reported that social distancing has actually led them to find new sources of satisfaction in life. "Our study also highlighted that encouraging safe social contact through physical activity and engaging with people in the community may be an effective way to reduce loneliness, improve wellbeing, increase social activity, and improve social support." The study - which involved a survey conducted between May and July 2020 - examined the impact of social distancing during the pandemic on loneliness, wellbeing and social activity, including social support, in Scottish older adults. Participants were asked about the strategies they adopted to increase social interaction during this time and reported that the way they interacted with their friends and family, faith, chosen group activities and, to a lesser extent, their employer and colleagues, had changed. More than 300 participants mentioned 'Zoom' - the video conferencing tool - in their answers. More than 150 participants reported that their religious gatherings had moved online - replacing face-to-face gatherings - while 91 said that social gatherings with family and friends had changed in favour of online 'games nights'. New activities included bingo and quiz nights, while other activities moved online - such as bridge nights, book clubs, choir rehearsals, and dance and exercise classes. The role of community - particularly neighbours - was mentioned by more than 300 participants and some reported the common experience of getting to know previously unknown neighbours and increase interaction with others in the community at local shops or parks. A pleasant Scottish summer also supported such interactions, several said. At least 100 people said social interactions were linked to their physical activities - such as time spent outdoors while walking for exercise, walking the dogs or active commuting. Professor Whittaker added: "Our research underlines the importance of addressing loneliness and social support in older adults - but particularly during situations where risk of isolation is high. Although specific to the pandemic, this study has wider implications of helping us to understand the impact of social distancing and social isolation on older people. "The findings may be applicable in the future - both in and outwith pandemic situations. In Scotland, the recommendations for improvement may be through encouraging older adults to get to know their neighbours better, getting involved with local buddying systems and community initiatives, including via digital means, and engaging in physical activity, such as daily walks in the community." Brian Sloan, Chief Executive of Age Scotland, said: "While it may prove difficult to consider any aspect of the pandemic positive as such, it is important and worthwhile to reflect on what it has taught us, both about ourselves and society and about the necessary tools to tackle Scotland's increased levels of loneliness and isolation. "For example, we've seen first-hand how important the community response has been in terms of supporting older people throughout lockdown and it has been inspiring to witness how people across the country stepped in and stepped forward to help those in need around them. Even as restrictions ease, we hope to see this sense of community spirit continue.  "The ongoing impact of COVID-19 has also demonstrated just how important increased digital inclusion is and how easily those without access to technology can feel out of the loop. It's reassuring to see so many older people reporting that they have been able to embrace and engage with technology to stay connected and active.  "However, it's equally important to ensure those who are unable or do not wish to use the internet have alternative ways to stay connected to their communities and support networks. "As we take steps towards recovery together, it is vital that no one is left behind and those most impacted are supported to play a full part in society again.  "We know we will be living with the ongoing effects of lockdown loneliness for a long time to come, and this research will be incredibly valuable when considering how best to tackle loneliness and isolation and to improve the wellbeing of older people going forward."     Signs of Vitamin B12 Deficiency World Health Net,  May 1, 2021 Modern nutritional research offers much more information about which nutrients are required for optimal health than in years past. The general opinion of most health care providers has been that patients should eat a balanced diet in order to make sure their nutritional needs are being met. Until the past few decades this was good advice, but the nutrients contained in most foods sold in grocery stores has been depleted, due to the way they were grown and processed. This means the nutrients most important to the proper functioning of the human body are best ingested through supplementation. Those who have a deficiency of vitamin B12 may be experiencing some serious health problems that they are not even aware of. Food Sources of Vitamin B12 Food products that come from animals are the only sources of the vitamin, so someone who follows a vegetarian or vegan diet would most likely need to supplement B12. It is also good to supplement if one has a diet that restricts the consumption of meat, dairy, eggs because of the relatively high levels of cholesterol and fat.  Health Problems Caused by a Vitamin B12 Deficiency Some of these health issues are easily mistaken as symptoms of other diseases, such as diabetes. Others may be confused with common aging problems. Weakness Fatigue Tingling and/or numbness in the extremeties Memory loss and cognitive difficulties Difficulty in walking, because of staggering or balance problems Health care providers may not be able to identify these problems as a deficiency of Vitamin B12, so a blood test may be needed, in order to reach a correct diagnosis. There are a few other less common symptoms that indicate a deficiency of the vitamin. Paranoia and hallucinations Anemia Jaundiced skin An inflamed and swollen tongue Many people are not very well educated about their nutritional needs and the problems they may experience from various deficiencies. Most people have too much stress in their lives and struggle to find enough time in the day to get everything done. People often naturally think whatever fatigue or weakness they feel is the result of not enough time and rest, but symptoms could well be due to a Vitamin B12 deficiency.  Although seniors are most at risk for nutritional deficiencies due to dietary restrictions, a depressed appetite and medications, younger women also experience anemia due to monthly menstruation. The average person is often surprised how much better they feel once they begin a regime of Vitamin B12 supplementation. It is important to note that not all B12 supplements are the same, so if adding the vitamin to a diet it would be wise to research all the options available. One common B12 supplement actually contains arsenic and should be avoided. Since the best source of B12 is found in foods, eating more meat, eggs, dairy and especially poultry is a good choice. Poultry is relatively low in fat and cholesterol, so it is safer for those who are at risk for heart disease.

Nalanie Chellaram has been surrounded by spirituality for her whole life. She was raised by Hindu parents, educated at a Catholic school and, studied philosophy in college. Nalanie began practicing the teaching of her Guru, Sri Swami Satchidananda in 1986 and continued to study the science of yoga. She has been accredited by the Council of Teachers of the Satchidananda Ashram in Virginia, USA. to teach Asanas, Pranayama and Meditation. She is also an accredited Teacher Trainer for Integral Yoga and a therapist under the British School of Yoga. She is the Chairwoman of the Integral Yoga Center in Gibraltar where she runs regular weekly satsangs, teacher training and counseling sessions. This Center is a registered Charity serving the community. Nalanie, who now lives in Spain, frequently lectures on the Science of Yoga, in Portugal, Spain. Germany. the United Kingdom, the USA and the Far East. She is the first of a new generation of spiritual teachers. Her particular upbringing and education has given her a special insight into both Hinduism and Christianity, inspired by her Beloved Guru. Find out more about Nalanie and the Integral Yoga Center in Gibraltar http://www.integralyogagib.com/ See acast.com/privacy for privacy and opt-out information.

In this episode we are going to talk about emotions, the Solar Plexus Center in Human Design, and what it means to be Defined or Undefined. Emotions are EVERYTHING! They create our world, they are our guidance system and we can learn to embrace them! Join the private Facebook Group for Female Entrepreneurs! Includes a code for $20 off your Human Design Reading, freebies, and more! >>> www.facebook.com/groups/waisocietyWant to know more about your Human Design?In this 90 minute session, we will go over your Type, Authority, Strategy, Profile, Centers, Variables, and more! Human Design offers insights into who you are, your strengths, opportunities for growth, and a strategy for making correct decisions so that you can start living the life you’ve always dreamed of! >>> www.waisoceity.com/humandesignLooking for a Coach?I feel like finding a coach is like dating. If you feel like we might be a good match, go here to learn more and schedule your Complimentary Breakthrough Call now! >>> www.waisociety.com/findyourwaiSolar Plexus CenterThe Solar Plexus Center is another powerful motor that is the Center for emotions and feelings. This Center has a major effect on all of us regardless of whether it is defined or open. Defined You are an emotional being. This Center operates in a wave moving you through emotional cycles from highs to lows in a two- or three-day cycle. The most important thing to know, there is no truth in the nowNever make a decision without "sleeping on it." You need to contemplate proposals through all phases of your emotional cycle before making a decision. Emotional beings need time. You may never have 100% clarity on a situation, but 80% certainty is sufficientAccept yourself in all states, you are an emotional influencer! When you are happy, others are happy, when you are sad, others are sadCommunicate your emotions to those around youUndefinedYour emotional state is dependant on who’s in your auraYou will take in other people's feelings, and you will feel happy or sad depending on the emotions of the people you are with. Your natural state is cool, calm and collectedYou are a barometer for the emotional state of those around youLearn to right the emotional waves of others to find what’s right for youRECAPEmotions are so important! Learning how to accept them, and alchemize them is everythingRemember to have an attitude of wonder, curiosity, and compassion for yourself during this journey. Follow me@waisociety on FB, IG, and YoutubeSubscribeNext week We are going to be talking about how to create a morning ritual!

In our latest episode of the Wharton Fintech podcast, Miguel Armaza (WG’21/G’21) is joined by Marc Weiser, Founder & Managing Director of RPM Ventures, an early-stage venture capital firm. Marc is also a board member of NASA and the James Beard Foundation. Marc Weiser is the Founder and Managing Director of RPM Ventures, a seed and early stage venture firm where he focuses on investing in mobility and autonomous vehicle companies. Over the last 15 years he has served on over 20 boards of directors and currently sits on the boards of: BountyJobs, the leading contingency recruiting marketplace; Mobi, a machine learning, multi-modal, dynamic route planning system; and Polysync, a platform for delivering safe and reliable autonomous vehicles. Prior to forming RPM, Mr. Weiser was an internet and software entrepreneur. He co-founded and led technology development at QuantumShift, a provider of web-based business-to-business technology and services focused on corporate telecommunications needs. He was also an early employee at MessageMedia (acquired by DoubleClick) where he pioneered some of the original methods for e-commerce and helped lead the company’s IPO. In addition to his board roles for RPM, Marc serves as Vice-Chair of McKinley, Inc., and the Board of Trustees of the James Beard Foundation. Previously he was the founding member of the Board for the Center for Entrepreneurship (CFE) and Wolverine Venture Fund at the University of Michigan, where he was adjunct professor. He is the recipient of the University of Michigan College of Engineering Alumni Distinguished Service Award for his efforts in founding the CFE, the TechArb (student accelerator), and the Masters in Entrepreneurship (a joint program between the College of Engineering and Ross School of Business). Additionally, he and his wife led the creation of the Mary H. Weiser Food Allergy Center at the University of Michigan. This Center provides national leadership in food allergy research and a path to a cure for those that suffer from food allergies. Marc graduated cum laude from the University of Michigan with a BSE in aerospace engineering and an MBA with highest honors. In this interview, Marc shares: - His background and how he landed the role of employee #1 at MessageMedia (acquired by DoubleClick), the first online payments system company in the early 1990s. - Why he decided to Co-Found QuantumShift, a SAS company, in 1996 and the reason why he calls this experience a "successful failure". - Launching RPM and the challenges of starting a Venture Capital fund in the year 2000. - The reason why after several years of operations, RPM narrowed its scope to invest only in Mobility and Fintech. - His conviction that most startups that win are the ones that generally fall over in the right direction and then pick themselves back up and then fall over again in the right direction again. The ones that do this process faster are the ones that win. - His fascinating journey as an early stage investor and advisor of SoFi. - What an RPM entrepreneur looks like. Hint: “We look for entrepreneurs that can run up the beat at the machine gun nest while simultaneously biting the heads off of chickens.” - The importance of investing in companies that have no rational chance of success. - His journey to becoming a board member at NASA and why this is his proudest personal achievement. - Going from restaurant investor to board member of the James Beard foundation. The devastating effects of the COVID-19 crisis on the industry and how the James Beard foundation is helping save the restaurant industry.

Gain the Coaching Necessary to be Self-Directed and Self-Selected on our latest Business Podcast episode.  Colby B. Jubenville, PPh.D.is an accomplished author, international speaker, professor, business advisor, entrepreneur, and inventor. He holds an ACA, emic appointment at Middle Tennessee State University as Special Assistant to the Dean for Student Success and Strategic Partnerships in the College of Behavioral and Health Sciences. What is CBHS?We help students develop their knowledge, skills, desire, confidence, likeability, and networks in order to compete in the marketplace of ideas. Today, students make a commitment to higher education investing their time, money and energy with the belief that we have the people and resources to help them become gainfully employed. This Center was built to do just that.   On This Episode You Will Hear:[spp-timestamp time="00:30"] Introduction [spp-timestamp time="08:40"] It is culturally ingrained in our traditional education system to focus on weaknesses vs strengths. [spp-timestamp time="11:55"] We are commanded to find our voice. What is your Voice? Your Voice is the intersection of talent, passion, conscious and needs in the world that only you can provide. [spp-timestamp time="12:20"] Focusing on your strengths... Unique ability by Dan Sullivan. There are four levels of work; Incompetence, Competence, Excellence, and then there is Unique Ability. [spp-timestamp time="21:00"] Not knowing, not doing, not understanding. [spp-timestamp time="28:55"] What did Colby start with first to start building his brand and his exposure? It started with being an educator and a coach first. [spp-timestamp time="34:30"] Colby fails just like you. You don't learn the most through the failure, you learn the most through FEEDBACK. [spp-timestamp time="44:00"] Business is relationships. Managers solve problems and make decisions. Where is that being taught in traditional education. This is where Colby created the Self-Directed, Self-Selected Coaching Model. [spp-timestamp time="53:50"] Final Words   SUCCESS: If one advances confidently in the direction of his dreams, and endeavors to live the life which he has imagined, he will meet with a success unexpected in common hours. - David Thoreau [spp-tweet tweet="Get yourself Directed and Selected. Learn about the SDSS Coaching Model! @DrJubenville "] Watch On YouTube:[youtube https://www.youtube.com/watch?v=3m2cXx1I8Bw] Links and Resources: Dr. Jubenville.com (http://drjubenville.com) Follow Dr. Jubenville on Twitter (https://twitter.com/drjubenville) CBHS Center for Student Coaching and Success (http://www.mtsu.edu/cbhssuccess/) Book: Zebras & Cheetahs (https://amzn.to/2NWNShA) PDF of the SDSS Model (https://mtsu.edu/cbhssuccess/images/NEWSDSS.jpg)   People Mentioned: Tom Rath author of Strengths Finder 2.0 (http://www.tomrath.org/book/strengthsfinder/) Dan Sullivan of Unique Ability (http://uniqueability.com/)   Final Words:SUCCESS Defined: If one advances confidently in the direction of his dreams, and endeavors to live the life which he has imagined, he will meet with a success unexpected in common hours. - David Thoreau What does it mean for you to advance confidently? What are you willing to do so that you can achieve it? What is the direction of your own dreams? Nobody else can define the dream for you. You have to define it for yourself.   Action Steps:Please Subscribe and Submit an iTunes Show Rating & Review (https://itunes.apple.com/us/podcast/livethefuel/id1150969758?mt=2) . The more reviews, the more people can find us. We love 5 Stars too! Join our private Facebook Group community called THE FUEL TANK (http://livethefueltank.com/) . Visit our  Resources (https://livethefuel.com/resources)  page and a reminder...

Presented in collaboration with the Association for Middle Level Education. Jokes You Can Use: Eileen Award: Twitter: William Gould, Val Jones, Mark Maudlin, Jessica Herring, Bren Martin Advisory: Skeptic 101 THE SKEPTICAL STUDIES CURRICULUM RESOURCE CENTER is a comprehensive, free repository of resources for teaching students how to think skeptically. This Center contains an ever-growing selection of books, reading lists, course syllabi, in-class exercises, PowerPoint presentations, student projects, papers, and videos that you may download and use in your own classes. Lessons in these resources include: what science is, how it differs from pseudoscience, and why it matters the scientific method and how to use it to investigate and conduct skeptical analyses of extraordinary claims how to construct effective arguments and rhetorical strategies how to effectively use presentations and papers to present an argument reason, logic, and skeptical analysis the psychology of belief how ideas are presented within academia how peer review works and much more… http://www.skeptic.com/skepticism-101/ Hand gestures http://www.pimsleurapproach.com/blog/language-learning/the-hand-jive-hand-gestures-infographic Middle School Science Minute by Dave Bydlowski (k12science or davidbydlowski@mac.com) MIDDLE SCHOOL SCIENCE MINUTE-THE LEONARDO STRATEGY I was recently reading the January, 2014 issue of Science Scope, a magazine written for Middle School Science Teachers, published by the National Science Teachers Association. In this issue, I was reading the article, "The Leonardo Strategy" written by Renee Clary and James Wandersee. In this article, they look at scientific discourse and argumentation in an online environment. http://k12science.net/Podcast/Podcast/Entries/2014/1/19_Middle_School_Science_Minute-The_Leonardo_Strategy.html From the Twitterverse: #mschat every Thursday at 8:00 pm Eastern Standard Time. And as Troy says, “The Twitter never stops!” Strategies: Professional Development Be glad this isn’t you. http://www.youtube.com/watch?v=eAy3vJn4pbs#t=34 Cultivate a Learning Mindset: Passion What can be seen in an organization with a learning mindset characterized by passion? http://blog.clerestorylearning.com/cultivate-a-learning-mindset-passion Characteristics of Good Leadership http://infographicjournal.com/characteristics-of-good-leadership/ Resources: Chogger Create comics online. http://chogger.com/ Web Spotlight: 25 Literary Opening Lines Diagrammed on One Giant Poster http://mentalfloss.com/article/55248/25-literary-opening-lines-diagrammed-one-giant-poster 25 maps and charts that explain America today http://www.washingtonpost.com/blogs/govbeat/wp/2014/02/24/25-maps-and-charts-that-explain-america-today/ Real Discipline in School http://mobile.nytimes.com/2014/02/17/opinion/real-discipline-in-school.html Nine-hour school day is the norm – and a national model – at Oakland middle school http://edsource.org/today/2014/oakland-middle-schools-9-hour-school-day-is-model-program/57269 Random Thoughts . . . Blended Learning. Class I’m taking as a student. Special shout out to Ron King for his contributions.

This Center for Social Development Lecture's guest speaker is Professor Fred Ssewamala from Columbia University. In this lecture, he speaks on health outcomes and how they relate to economic development. Dr. Fred Ssewamala is an Associate Professor of Social Work and International Affairs at Columbia University School of Social Work; a Global Thought Fellow with Columbia University; and a Senior Research Fellow with New America Foundation. Dr. Ssewamala has several years of practice in the International Social Development field. His practice experience includes serving at the Red Cross (Uganda), where he acted in several programmatic positions related to designing projects and programs for poverty alleviation and community development, and at Justine Petersen Housing and Reinvestment Corporation a 501(c) (3) Missouri (USA) not-for-profit corporation that assists low-to-moderate income individuals and families become homeowners, access financial institutions, start their own micro-businesses, and accumulate assets.