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JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2HEALTH AUTONOMY [COURSE]Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomyJOIN THE COMMUNITYJoin my Community [It's Free!]: https://bit.ly/PhysionicCommunity2EMAIL LIST1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6HIRE ME FOR CONSULTING:Consulting: https://bit.ly/3dmUl2HCreated with Biorender0:00 - Introduction1:22 - Option 12:20 - Option 23:55 - Option 35:55 - Option 4References[1] Kadowaki T, et al. Obes Res Clin Pract. 2025;19(2):146-153. doi:10.1016/j.orcp.2025.03.003.[2] Wilding JPH, et al. J Endocr Soc. 2021;5(Suppl 1):A16-A17. doi:10.1210/jendso/bvab048.030.[3] Arciero PJ, et al. Obesity. 2023;31(Suppl 1):139-149. doi:10.1002/oby.23660.[4] Zuo L, et al. Front Physiol. 2016;7:350. doi:10.3389/fphys.2016.00350.[Study 396] Zelicha H, et al. BMC Med. 2022;20:327. doi:10.1186/s12916-022-02525-8.[Study 427] Kaplan A, et al. Am J Clin Nutr. 2022;115(5):1270-1281. doi:10.1093/ajcn/nqac001.[Study 780] Look M, et al. Diabetes Obes Metab. 2025;27(5):2720-2729. doi:10.1111/dom.16275.[Study 790] Falutz J, et al. J Clin Endocrinol Metab. 2010;95(9):4291-4304. doi:10.1210/jc.2010-0490.[Study 793] Makimura H, et al. J Clin Endocrinol Metab. 2012;97(12):4769-4779. doi:10.1210/jc.2012-2794.[Study 509] Di Tano M, et al. Nat Commun. 2020;11:2332. doi:10.1038/s41467-020-16243-3.[Study 510] Vernieri C, et al. Cancer Discov. 2022;12(1):90-107. doi:10.1158/2159-8290.CD-21-0030.[Study 511] Ligorio F, et al. Int J Cancer. 2024;154(1):114-123. doi:10.1002/ijc.34701.[Study 512] Vernieri C, et al. Cell Metab. 2024;36(8):1644-1667. doi:10.1016/j.cmet.2024.06.014.[Study 606] Ni Y, et al. Cell Metab. 2023;35(9):1530-1547. doi:10.1016/j.cmet.2023.08.002.[Study 607] Long X, et al. Cell Metab. 2025;37:2342-2361. doi:10.1016/j.cmet.2025.10.017.[Study 608] Li H, et al. Nat Metab. 2024;6(3):578-597. doi:10.1038/s42255-024-00988-y.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction2:13 - Blood Cholesterol is not Important13:08 - Something else matters WAY more than Blood Cholesterol16:45 - Main PointsReferences[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Khan SS, Matsushita K, Sang Y, et al. Development and validation of the American Heart Association's PREVENT equations. Circulation. 2024;149:430–449. doi:10.1161/CIRCULATIONAHA.123.067626.[2] Dugani SB, Moorthy MV, Li C, et al. Association of lipid, inflammatory, and metabolic biomarkers with age at onset for incident coronary heart disease in women. JAMA Cardiol. 2021;6(4):437–447. doi:10.1001/jamacardio.2020.7073.[3] Magnussen C, Alegre-Diaz J, Al-Nasser LA, et al. Global effect of cardiovascular risk factors on lifetime estimates. N Engl J Med. 2025;393(2):125–138. doi:10.1056/NEJMoa2415879.[4] Blumenthal RS, Morris PB, Gaudino M, et al. 2026 ACC/AHA/AACVPR/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA guideline on the management of dyslipidemia: a report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. Circulation. 2026;153:e1154–e1276. doi:10.1161/CIR.0000000000001423.[5] Cannon CP, Blazing MA, Giugliano RP, et al; IMPROVE-IT Investigators. Ezetimibe added to statin therapy after acute coronary syndromes. N Engl J Med. 2015;372(25):2387–2397. doi:10.1056/NEJMoa1410489.[6] Nordestgaard BG, Langlois MR, Langsted A, et al. Quantifying atherogenic lipoproteins for lipid-lowering strategies: Consensus-based recommendations from EAS and EFLM. Atherosclerosis. 2020;294:46–61. doi:10.1016/j.atherosclerosis.2019.12.005.[7] Prospective Studies Collaboration, Lewington S, Whitlock G, et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007;370(9602):1829–1839. doi:10.1016/S0140-6736(07)61778-4.[8] Johannesen CDL, Langsted A, Mortensen MB, Nordestgaard BG. Association between low density lipoprotein and all cause and cause specific mortality in Denmark: prospective cohort study. BMJ. 2020;371:m4266. doi:10.1136/bmj.m4266.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender750% increased Pancreatic Cancer: https://www.youtube.com/watch?v=_YPIO9CBuw8&t=1s0:00 - Introduction0:25 - CAFs, Vitamin D Receptor, and Cancer3:41 - What happens?5:57 - Why are the results the way they are?8:00 - Vitamin D39:30 - My backlight died and ConclusionsReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1045] Perez KJ, et al. Gemcitabine and nab-paclitaxel ± paricalcitol for metastatic pancreatic cancer. Nat Cancer. 2026;7:928–943.[Study 1046] Sherman MH, et al. Vitamin D receptor-mediated stromal reprogramming enhances pancreatic cancer therapy. Cell. 2014;159:80–93.[Study 1047] Grierson PM, et al. Paricalcitol plus nanoliposomal irinotecan and 5-FU/LV in advanced pancreatic cancer. Clin Cancer Res. 2023;29:4733–4739.[Study 1048] Chung V, et al. Pembrolizumab ± paricalcitol in metastatic pancreatic cancer. Oncologist. 2025;30.[Study 1049] Easty D, et al. Paricalcitol with gemcitabine and nab-paclitaxel in advanced pancreatic cancer. BMC Cancer. 2026;26:255.[Study 1050] Viniotis AF, et al. NABPLAGEM and paricalcitol as neoadjuvant therapy in pancreatic cancer. Oncologist. 2026;31.[Study 1051] Rasmussen LS, et al. Vitamin D deficiency, inflammation, and survival in pancreatic cancer. Eur J Cancer. 2021;144:72–80.[Study 1052] Yuan C, et al. Prediagnostic 25-hydroxyvitamin D and pancreatic cancer survival. J Clin Oncol. 2016;34:2899–2905.[Study 1053] Cho M, et al. Vitamin D deficiency and prognosis in pancreatic adenocarcinoma. J Transl Med. 2013;11:206.[Study 1054] Van Loon K, et al. 25-Hydroxyvitamin D and survival in advanced pancreatic cancer. J Natl Cancer Inst. 2014;106.[Study 1055] Mukai Y, et al. Vitamin D supplementation with chemoradiation for pancreatic ductal adenocarcinoma. Ann Surg Oncol. 2018;25:1868–1879.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with BiorenderMain Walnut-Mortality Analysis: https://www.youtube.com/watch?v=3DqCZZgDdF8&t=337s0:00 - Introduction0:45 - It's a Meee, Cholesterol!3:15 - You heard me, I called you Endothelial5:12 - A New View of Inflammation7:35 - How much to eat?References [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1037] Rajaram S, Cofán M, Sala-Vila A, et al. Effects of walnut consumption for 2 years on lipoprotein subclasses among healthy elders: findings from the WAHA randomized controlled trial. Circulation. 2021;144:1083-1085. doi:10.1161/CIRCULATIONAHA.121.054051.[Study 1038] Wu L, Piotrowski K, Rau T, et al. Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial. Metabolism. 2014;63:382-391. doi:10.1016/j.metabol.2013.11.005.[Study 1039] Ros E, Núñez I, Pérez-Heras A, et al. A walnut diet improves endothelial function in hypercholesterolemic subjects: a randomized crossover trial. Circulation. 2004;109:1609-1614. doi:10.1161/01.CIR.0000124477.91474.FF.[Study 1040] Katz DL, Davidhi A, Ma Y, et al. Effects of walnuts on endothelial function in overweight adults with visceral obesity: a randomized, controlled, crossover trial. J Am Coll Nutr. 2012;31(6):415-423.[Study 1041] Berryman CE, Grieger JA, West SG, et al. Acute consumption of walnuts and walnut components differentially affect postprandial lipemia, endothelial function, oxidative stress, and cholesterol efflux in humans with mild hypercholesterolemia. J Nutr. 2013;143:788-794. doi:10.3945/jn.112.170993.[Study 1042] Chiang YL, Haddad E, Rajaram S, Shavlik D, Sabaté J. The effect of dietary walnuts compared to fatty fish on eicosanoids, cytokines, soluble endothelial adhesion molecules and lymphocyte subsets: a randomized, controlled crossover trial. Prostaglandins Leukot Essent Fatty Acids. 2012;87:111-117. doi:10.1016/j.plefa.2012.07.007.[Study 1043] Cofán M, Checa A, Serra-Mir M, et al. A walnut-enriched diet for 2 years changes the serum oxylipin profile in healthy older persons. J Nutr. 2024;154:395-402. doi:10.1016/j.tjnut.2023.12.007.[Study 1044] Holscher HD, Guetterman HM, Swanson KS, et al. Walnut consumption alters the gastrointestinal microbiota, microbially derived secondary bile acids, and health markers in healthy adults: a randomized controlled trial. J Nutr. 2018;148:861-867. doi:10.1093/jn/nxy004.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:59 - You're Stressin' Me, Man, my Glucose is High!5:21 - Not all roads lead to Serine6:10 - A Serine StoryReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1032] He A, Zhu Y, Liang C, et al. Amygdala astrocyte senescence drives stress-induced anxiety and hyperglycemia. Cell Metab. 2026;38:1385-1403. doi:10.1016/j.cmet.2026.03.006.[Study 1033] Roberts AL, Agnew-Blais JC, Spiegelman D, et al. Posttraumatic stress disorder and incidence of type 2 diabetes mellitus in a sample of women: a 22-year longitudinal study. JAMA Psychiatry. 2015;72(3):203-210. doi:10.1001/jamapsychiatry.2014.2632.[Study 1034] Vaccarino V, Goldberg J, Magruder KM, et al. Posttraumatic stress disorder and incidence of type-2 diabetes: a prospective twin study. J Psychiatr Res. 2014;56:158-164. doi:10.1016/j.jpsychires.2014.05.019.[Study 1035] Nowotny B, Cavka M, Herder C, et al. Effects of acute psychological stress on glucose metabolism and subclinical inflammation in patients with post-traumatic stress disorder. Horm Metab Res. 2010;42:746-753. doi:10.1055/s-0030-1261924.[Study 1036] Heresco-Levy U, Vass A, Bloch B, et al. Pilot controlled trial of D-serine for the treatment of post-traumatic stress disorder. Int J Neuropsychopharmacol. 2009;12:1275-1282. doi:10.1017/S1461145709000339.Please use the following link to submit your critique: https://bit.ly/PhysionicCritique

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:18 - Peptides on Cardiovascular Disease3:09 - Peptides on Reversing Arterial Plaque6:58 - There is hope...References [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1018] Marso SP, et al. Semaglutide and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med. 2016. doi:10.1056/NEJMoa1607141.[Study 1019] Gerstein HC, et al. Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND). Lancet. 2019. doi:10.1016/S0140-6736(19)31149-3.[Study 1020] Gerstein HC, et al. The effect of dulaglutide on stroke: an exploratory analysis of REWIND. Lancet Diabetes Endocrinol. 2020. doi:10.1016/S2213-8587(19)30423-1.[Study 1021] Hernandez AF, et al. Albiglutide and cardiovascular outcomes in type 2 diabetes and cardiovascular disease. Lancet. 2018. doi:10.1016/S0140-6736(18)32261-X.[Study 1022] Lincoff AM, et al. Semaglutide and cardiovascular outcomes in obesity without diabetes. N Engl J Med. 2023. doi:10.1056/NEJMoa2307563.[Study 1023] McGuire DK, et al. Oral semaglutide and cardiovascular outcomes in high-risk type 2 diabetes. N Engl J Med. 2025. doi:10.1056/NEJMoa2501006.[Study 1024] Gitto M, et al. GLP-1 receptor agonists and coronary plaque regression after acute coronary syndromes. Acta Diabetol. 2026. doi:10.1007/s00592-025-02606-z.[Study 1025] Kataoka Y, et al. GLP-1 analogues and delipidation of coronary atheroma. Atheroscler Plus. 2024. doi:10.1016/j.athplu.2024.03.001.[Study 1026] Heinsen LJ, et al. Liraglutide treatment and progression of coronary artery fibrous plaque. BMC Cardiovasc Disord. 2023. doi:10.1186/s12872-023-03228-5.[Study 1027] Zhang J, et al. Exenatide versus insulin and carotid intima-media thickness in type 2 diabetes. Cardiovasc Diabetol. 2020. doi:10.1186/s12933-020-01014-7.[Study 1028] Rizzo M, et al. Liraglutide decreases carotid intima-media thickness in type 2 diabetes. Cardiovasc Diabetol. 2014. doi:10.1186/1475-2840-13-49.[Study 1029] Rizzo M, et al. Liraglutide improves metabolic parameters and carotid intima-media thickness. Cardiovasc Diabetol. 2016. doi:10.1186/s12933-016-0480-8.[Study 1030] Patti AM, et al. Semaglutide and subclinical atherosclerosis in type 2 diabetes. Biomedicines. 2023. doi:10.3390/biomedicines11051362.[Study 1031] Sun L, et al. Liraglutide and atherosclerosis in impaired glucose tolerance. Exp Ther Med. 2023. doi:10.3892/etm.2023.11948.[Study 997] Lundgren JR, et al. Healthy weight loss maintenance with exercise, liraglutide, or both. N Engl J Med. 2021. doi:10.1056/NEJMoa2028198.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction1:09 - No Good Research on Health Effects of Fiber5:21 - This is what we Need!8:08 - Whoops.. Hypocrisy? 12:50 - Main PointsReferences [1] Park Y, Subar AF, Hollenbeck A, Schatzkin A. Dietary fiber intake and mortality in the NIH-AARP diet and health study. Arch Intern Med. 2011;171(12):1061-1068. doi:10.1001/archinternmed.2011.18[2] Chuang SC, Norat T, Murphy N, et al. Fiber intake and total and cause-specific mortality in the European Prospective Investigation into Cancer and Nutrition cohort. Am J Clin Nutr. 2012;96(1):164-174. doi:10.3945/ajcn.111.028415[3] Buil-Cosiales P, Zazpe I, Toledo E, et al. Fiber intake and all-cause mortality in the Prevención con Dieta Mediterránea (PREDIMED) study. Am J Clin Nutr. 2014;100(6):1498-1507. doi:10.3945/ajcn.114.093757[4] Li S, Flint A, Pai JK, et al. Dietary fiber intake and mortality among survivors of myocardial infarction: prospective cohort study. BMJ. 2014;348. doi:10.1136/bmj.g2659[5] Katagiri R, Goto A, Sawada N, et al. Dietary fiber intake and total and cause-specific mortality: the Japan Public Health Center-based prospective study. Am J Clin Nutr. 2020;111(5):1027-1035. doi:10.1093/ajcn/nqaa002[6] Burn J, Bishop DT, Mecklin JP, et al. Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome. N Engl J Med. 2008;359(24):2567-2578. doi:10.1056/NEJMoa0801297[7] Robertson MD, Bickerton AS, Dennis AL, Vidal H, Frayn KN. Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. Am J Clin Nutr. 2005;82(3):559-567. doi:10.1093/ajcn.82.3.559[8] Ziai SA, Larijani B, Akhoondzadeh S, et al. Psyllium decreased serum glucose and glycosylated hemoglobin significantly in diabetic outpatients. J Ethnopharmacol. 2005;102(2):202-207. doi:10.1016/j.jep.2005.06.042[9] Abutair AS, Naser IA, Hamed AT. Soluble fibers from psyllium improve glycemic response and body weight among diabetes type 2 patients (randomized control trial). Nutr J. 2016;15(1):86. doi:10.1186/s12937-016-0207-4[10] Solà R, Bruckert E, Valls RM, et al. Soluble fibre (Plantago ovata husk) reduces plasma low-density lipoprotein (LDL) cholesterol, triglycerides, insulin, oxidised LDL and systolic blood pressure in hypercholesterolaemic patients: A randomised trial. Atherosclerosis. 2010;211(2):630-637. doi:10.1016/j.atherosclerosis.2010.03.010[11] Burke V, Hodgson JM, Beilin LJ, Giangiulioi N, Rogers P, Puddey IB. Dietary protein and soluble fiber reduce ambulatory blood pressure in treated hypertensives. Hypertension. 2001;38(4):821-826. doi:10.1161/hy1001.092614[12] Wolever TM, Jenkins DJ, Mueller S, et al. Psyllium reduces blood lipids in men and women with hyperlipidemia. Am J Med Sci. 1994;307(4):269-273. doi:10.1097/00000441-199404000-00005Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:48 - Freezing Aging through Exercise4:18 - The Exercise Methylome7:02 - A Bit Gene CrazyReferences[Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][Study 1006] Janssens GE, Trętowicz MM, Grevendonk L, et al. Delayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle. Nat Aging. 2026;6:1482-1500. doi:10.1038/s43587-026-01150-x.[Study 1007] Voisin S, Seale K, Jacques M, et al. Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle. Aging Cell. 2024;23:e13859. doi:10.1111/acel.13859.[Study 1008] Melov S, Tarnopolsky MA, Beckman K, Felkey K, Hubbard A. Resistance exercise reverses aging in human skeletal muscle. PLoS One. 2007;2(5):e465. doi:10.1371/journal.pone.0000465.Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Created with Biorender0:00 - Introduction0:15 - The Classics1:57 - What's the News?6:04 - BerberineReferences [Funding/Conflicts are provided in the free article (found in the email list and Physionic Community Article Library)][1] Dong H, Wang N, Zhao L, Lu F. Berberine in the treatment of type 2 diabetes mellitus: a systemic review and meta-analysis. Evid Based Complement Alternat Med. 2012;2012:591654. doi:10.1155/2012/591654[Study 985] Sebo ZL, Chakrabarty RP, Grant RA, D'Alessandro KB, Koss AR, Blum JLE, et al. Metformin inhibits mitochondrial complex I in intestinal epithelium to promote glycaemic control. Nat Metab. 2026;8:1291-1304. doi:10.1038/s42255-026-01530-y[Study 986] Koffert JP, Mikkola K, Virtanen KA, Andersson AMD, Faxius L, Hällsten K, et al. Metformin treatment significantly enhances intestinal glucose uptake in patients with type 2 diabetes: results from a randomized clinical trial. Diabetes Res Clin Pract. 2017;131:208-216. doi:10.1016/j.diabres.2017.07.015[Study 987] Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes. Metabolism. 2008;57(5):712-717. doi:10.1016/j.metabol.2008.01.013Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H Original Podcast: https://youtu.be/q57CNySsYxs?si=PIwVEVGj_-cYkDCU0:00 - Introduction1:54 - Genetics that cause High Cholesterol5:29 - The American Heart Association is lying to you8:05 - Extremely High Cholesterol doesn't Kill17:48 - High Cholesterol at 60? Protection from Death25:20 - Other ways of testing this?27:12 - Main PointsReferences[1] Mundal L, Sarancic M, Ose L, et al. Mortality among patients with familial hypercholesterolemia: a registry-based study in Norway, 1992–2010. *J Am Heart Assoc*. 2014;3(6):e001236. doi:10.1161/JAHA.114.001236[2] Brown MS, Goldstein JL. Familial hypercholesterolemia: defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity. *Proc Natl Acad Sci U S A*. 1974;71(3):788-792. doi:10.1073/pnas.71.3.788[3] Shishikura D, Harada-Shiba M, Michikura M, et al. Comparison of clinical characterization and therapeutic strategies between homozygous familial hypercholesterolemia and heterozygous familial hypercholesterolemia. *J Atheroscler Thromb*. 2026;33. Advance publication online March 27, 2026. doi:10.5551/jat.65959[4] Wiegman A, de Groot E, Hutten BA, et al. Arterial intima-media thickness in children heterozygous for familial hypercholesterolaemia. *Lancet*. 2004;363(9406):369-370. doi:10.1016/S0140-6736(04)15467-6[5] EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC). *Lancet*. 2021;398(10312):1713-1725. doi:10.1016/S0140-6736(21)01122-3[6] Clarke R, Emberson JR, Parish S, et al. Cholesterol fractions and apolipoproteins as risk factors for heart disease mortality in older men. *Arch Intern Med.* 2007;167(13):1373-1378.[7] Ding M, Wennberg A, Ek S, et al. The association of apolipoproteins with later-life all-cause and cardiovascular mortality: a population-based study stratified by age. *Sci Rep.* 2021;11(1):24440. doi:10.1038/s41598-021-03959-5.[8] Mortensen MB, Nordestgaard BG. Elevated LDL cholesterol and increased risk of myocardial infarction and atherosclerotic cardiovascular disease in individuals aged 70-100 years: a contemporary primary prevention cohort. *Lancet*. 2020;396(10263):1644-1652. doi:10.1016/S0140-6736(20)32233-9Please use the following link to submit your critique: https://bit.ly/PhysionicCritiqueDisclaimer: None of the information provided by this brand is a replacement for your physician's advice. This brand is information for the sake of knowledge and the options of choice it provides, not in any way a personalized prescription. Please consult your physician before making any health related changes.

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:*Consulting: https://bit.ly/3dmUl2H 0:00 - Introduction4:43 - Berberine on Colorectal Cancer21:36 - 5 Free Health Tests1:03:15 - Glycine Restriction and Cancer1:39:12 - Favorite Anti-Aging Hack2:06:00 - Lithium on Alzheimer's Disease2:29:20 - Vitamin K on Cardiovascular Disease3:14:00 - Housekeeping/Hanging Out

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]*Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy*JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2*EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6*HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H 0:00 - Introduction4:02 - Collagen for Skin 'Debunked'36:30 - Ketones track with Liver Disease52:15 - Butyrate and Cancer1:25:50 - Seed Oils - Harmful?1:59:55 - Ineffective Creatine2:17:17 - Non-Nutritive Sweeteners and Cognitive Decline2:42:39 - Housekeeping, Updates, Hangout

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders: https://bit.ly/PhysionicInsiders2 *HEALTH AUTONOMY [COURSE]*Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy *JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST*1-2 Weekly Email of Value [It's Free!]: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H  0:00 - Introduction 1:18 - What is NAD+? Why is it Important? 8:39 - Weight Loss and NAD+ 16:25 - The Dr. Sinclair Story 24:30 - Dr. Sinclair's focus on NAD+ 31:50 - How have Scientists boosted NAD+? 34:09 - Do NAD+ Boosters work? 45:36 - Different types of NAD+ Boosters 49:40 - Dr. Sinclair's newest NAD+ Study (Unpublished!) 1:05:28 - Exercise and other Strategies for NAD+ Boosting 1:10:15 - NAD+ in Women 1:13:55 - Nuchido Time+ NAD+ Study in Humans 1:29:51 - Summarizing/Take Aways 1:34:08 - Taking Niacin instead of other NAD+ Boosters? 1:38:05 - Conclusion/Just Chatting

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro   *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More   *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *HEALTH AUTONOMY [COURSE]* Learn to Analyze & Apply Studies for Yourself: https://bit.ly/healthautonomy *JOIN THE COMMUNITY* Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA* Instagram: http://bit.ly/2OBFe7i

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro   *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More   *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *JOIN THE COMMUNITY *Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA* Instagram: http://bit.ly/2OBFe7i

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro   *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More   *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *JOIN THE COMMUNITY*Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST*One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE*Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA*Instagram: http://bit.ly/2OBFe7i Nick's Channel: https://youtu.be/yiq67wpUhIs?si=AAercNmT4OX6fk_z Dave's Channel: https://youtu.be/RzG6N8WWufM?si=XNl6HTJ66vUpZ0QT 0:00 - Introduction of Study 3:47 - Introduction to Dr. Nick Norwitz and Dave Feldman 8:31 - Dr. Norwitz details the Oreo Study 31:52 - Problems with Science Communication 1:12:42 - Discussion with Dave Feldman 1:15:20 - Lipid Heart Model of Heart Disease 1:27:28 - Lean Mass Hyper-Responders 1:35:10 - Mechanisms of Action Discussion

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT] *Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro   *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More   *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *JOIN THE COMMUNITY* Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA* Instagram: http://bit.ly/2OBFe7i Dr. Stanfield's Channel: https://www.youtube.com/@DrBradStanfield Timestamps 0:00 – Introduction 1:05 – Nicotinamide Mononucleotide (NMN) 17:14 – Creatine 20:25 – Collagen Peptides 25:58 – Thoughts on Meta-Analyses 29:18 – Hyaluronic Acid 34:08 – Taurine 37:42 – Thoughts on Mouse Studies 39:55 – Do Blood Markers Matter for Longevity? 42:29 – Trusting Science/Experts 44:05 – Dr. Stanfield's Motivations for Clinical Education 53:12 – Ending Remarks

*JOIN THE PHYSIONIC INSIDERS [PREMIUM CONTENT]* Join the Physionic Insiders [Standard Tier]: https://bit.ly/PhysionicInsiders2 Join the Physionic Insiders [Pro Tier]: https://bit.ly/PhysionicInsidersPro *Standard Tier:* Access to the Premium Video Library, Full Study Analyses (+ Summaries), Insider Podcast, , Research Reviews, and More *Pro Tier:* All benefits of the Standard Tier + Live Sessions with Me, Consulting Lite, and More *JOIN THE COMMUNITY* Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity2 *EMAIL LIST* One Weekly Email of Value: http://bit.ly/2AXIzK6 *HIRE ME FOR CONSULTING:* Consulting: https://bit.ly/3dmUl2H *DONATIONS FOR A SCIENCE BASED CAUSE* Patreon: https://bit.ly/PhysionicPatreon *OTHER SOCIAL MEDIA* Instagram: http://bit.ly/2OBFe7i 0:00 - Introduction 5:11 - How to think about Aging 33:48 - Oxidized Blood Lipoproteins 58:34 - Study shows Age Reversal 1:15:28 - Oxalates 1:28:28 - Creatine as a Nootropic 1:35:48 - Niacin and Heart Disease 2:13:17 - Methylene Blue 2:25:25 - NMN on Health 2:38:46 - Inflammation contributing to Heart Disease 2:50:39 - Understanding Cellular Energy for Muscle Growth 3:07:08 - Subscriber Questions & Comments 3:42:05 - Housekeeping

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JOIN MY PHYSIONIC SOCIAL NETWORK Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity Join the Physionic Insiders [Premium]: https://bit.ly/PhysionicInsiders HIRE ME FOR CONSULTING: https://bit.ly/3dmUl2H DONATIONS FOR A SCIENCE BASED CAUSE Patreon: patreon.com/PhysionicPhD WHERE ELSE IM ACTIVE: Email: http://bit.ly/2AXIzK6 Podcast: http://bit.ly/2PThKz0 Instagram: http://bit.ly/2OBFe7i 0:00 – Introduction. 5:30 – Toxic Acrylamides in Coffee. 18:46 – The Physionic Dream. 50:05 – Sucralose and Insulin Sensitivity. 57:00 – Insulin & Body Fat. 1:23:25 – Carbohydrate-Insulin Model of Obesity. 2:17:35 – GlyNAC for Anti-Aging. 2:29:50 – Hyaluronic Acid on Skin Aging. 2:40:45 – The Future Content.

JOIN MY PHYSIONIC SOCIAL NETWORK Join my Community [It's Free!]: https://bit.ly/PhysionicCommunity Join the Physionic Insiders [Premium]: https://bit.ly/PhysionicInsiders HIRE ME FOR CONSULTING: https://bit.ly/3dmUl2H WHERE ELSE IM ACTIVE: Email: http://bit.ly/2AXIzK6 Podcast: http://bit.ly/2PThKz0 Instagram: http://bit.ly/2OBFe7i 0:00 - Introduction. 3:00 - Dr. John Campbell, High Intensity Health. 39:40 - Nutrition Gurus. 53:00 - My Investigation on Non-Nutritive Sweeteners. 1:03:05 - Improving the 'Detailed Study Analyses'. 1:09:53 - Sweeteners break your Fast? 1:14:23 - Alternate Day Fasting.

Hi, in this episode, I cover a bunch of topics from my experience at the doctor, my own hypocrisy, some things I learned from you, and finally - the main topic of discussion: Insulin resistance and how plastics (phthalates) affect it. Oh, and if you're on Spotify or YouTube, it's now a video podcast, as well! MY COURSES, INSIDERS COMMUNITY, & CONSULTING - Join the ‘Physionic Insiders' (Exclusive Content): https://www.patreon.com/PhysionicPhD - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

Hi folks, in this episode I unintentionally discussed two topics. One, I planned on discussing, which was caffeine and it's performance effects in weight lifting and endurance. However, because I woke myself up to a nutrition documentary that I watched for 20 minutes or so before recording, I felt I had to get some things off my chest related to the second topic - nutrition documentaries. So, you have the distinct pleasure (or dismay) of listening to me ramble on both, but I hope that either way you learn something of use, especially related to caffeine. MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Video and Studies on Caffeine: https://youtu.be/9WTbwlU5yOs

In this episode, the first of a more relaxed, long form podcast style, we're going to dive into how fat relates to cancers - the mechanisms, but beyond that, the different therapies employed by pharmaceuticals, along with the use of nutrition to combat certain cancers. MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Related Videos: Mechanisms: https://youtu.be/Ijt1lqxn2AQ Therapies: https://youtu.be/iLdcoIIiByo Scientific Review: Reprogramming of Fatty Acid Metabolism in Cancer British Journal of Cancer

I think you'd be better served if we change how we do things on the Physionic Podcast. MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, I'm going to begin the explanation as to what effects carbohydrates have on our metabolism, and one potential effect in our mitochondria. Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs34%5D-a-high-carbohydrate-diet-lowers-the-rate-of-adipose-tissue-mitochondrial-respiration Video: https://www.youtube.com/watch?v=7uBHNUSI6hI Previous Video on Carbs and Metabolism: https://www.youtube.com/watch?v=xn8VJzGCK5U&t=2s MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Study: A high-carbohydrate diet lowers the rate of adipose tissue mitochondrial respiration Benjamin Bikman

In this episode, we'll discuss a potential exception to the negative results on insulin sensitivity we've been discussing with the exposure to saturated fat. Study, Notes, & Amendments: https://www.physionic.org/examine/%5B31%5D-palmitate-acutely-induces-insulin-resistance-in-isolated-muscle-from-obese-but-not-lean-humans Video: https://youtu.be/ldUBG4-EJDo MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Study: Palmitate acutely induces insulin resistance in isolated muscle from obese but not lean humans. A Brianne Thrush

Hi all, in this episode, I'm going to describe to you how your nutrition, generally, affects your mitochondria in diabetes specific cells and how long term habits in nutrition can lead to diabetes (type 2). Enjoy. Video Version: https://youtu.be/x6EOhTzVKsE Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs32%5D-mitochondrial-dynamics-in-the-regulation-of-nutrient-utilization-and-energy-expenditure MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Study: Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure Marc Liesa

In this episode, we'll be diving into two ways your mitochondria change their "behavior" to the exposure to different nutrition situations (high vs low nutrient presence). Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs32%5D-mitochondrial-dynamics-in-the-regulation-of-nutrient-utilization-and-energy-expenditure Video: https://www.youtube.com/watch?v=KQBmtzT4VTU MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Study: Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure Marc Liesa

In this episode, we'll be going over a new study that wanted to find out the effects a saturated fat heavy consumption would have on insulin resistance and signaling against an unsaturated fat heavy consumption. Video: https://youtu.be/QfII7CANt14 Study: https://www.physionic.org/examine/%5Bs30%5D-dietary-palmitate-and-oleate-differently-modulate-insulin-sensitivity-in-human-skeletal-muscle MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 Sarabhai, T., Koliaki, C., Mastrototaro, L., Kahl, S., Pesta, D., Apostolopoulou, M., Wolkersdorfer, M., Bönner, A. C., Bobrov, P., Markgraf, D. F., Herder, C., & Roden, M. (2022). Dietary palmitate and oleate differently modulate insulin sensitivity in human skeletal muscle. Diabetologia, 65(2), 301–314. https://doi.org/10.1007/s00125-021-05596-z

In this episode, we continue our quest for understanding the effect saturated fats have on muscle insulin signaling and mitochondrial health - however, beyond that, we'll be looking at how unsaturated fats may protect against the deleterious effects of saturated fat? Let's see.. Study, Notes, & Amendments: https://www.physionic.org/examine/%5Bs28%5D-different-effects-of-oleate-vs.-palmitate-on-mitochondrial-function%2C-apoptosis%2C-and-insulin-signaling-in-l6-skeletal-muscle-cells%3A-role-of-oxidative-stress- Video: https://youtu.be/TiO16KoH0Fs Study Title: Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress. Larysa Yuzefovych

In this episode, I'm kicking off a new format that's more tailored to the podcast listeners, so there's less need to head to the video versions of the podcast to understand half of what I'm talking about. In this episode, we'll be discussing saturated fat (palmitate) and it's effects in relation to insulin signaling in muscle cells, as well as mitochondrial function. What are the effects? What are the implications? Video: https://youtu.be/zMkV91E2Bic Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3249685/

In this episode, I attempt to make sense of calories in vs out and reconcile that with the hormone argument for fat loss. Video Podcast: https://youtu.be/x1ZjjDzCdc0 MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

Mitochondria have a dark side, find out how. Video Podcast: https://www.youtube.com/watch?v=HPx7cv1I7eU MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this podcast, we look at a study that investigates how weight loss affects hormones and long term weight regain - is the deck stacked against you? Study: https://www.nejm.org/doi/full/10.1056/nejmoa1105816 Video Podcast: https://youtu.be/-t5d0S5MRwE 0:00 - Introduction 2:47 - Study Design 6:58 - Weight Loss & Weight Regain Results 9:45 - Long Term Hormonal Changes from Weight Loss 34:12 - Conclusions/Take Aways MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

How does intermittent fasting affect your health, even when you do not lose weight with it? Let's find out. Study: https://pubmed.ncbi.nlm.nih.gov/29754952/#:~:text=Men%20with%20Prediabetes-,Early%20Time%2DRestricted%20Feeding%20Improves%20Insulin%20Sensitivity%2C%20Blood%20Pressure%2C,Cell%20Metab. Video Podcast: https://youtu.be/1t0HUSlFNiQ MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 0:00 - Introduction 3:23 - Study Design 9:03 - Intermittent Fasting on Health Results 18:24 - "Fasting Increases Inflammation" 20:08 - Intermittent Fasting on Health Continued 23:00 - Conclusions/Take Aways

Title says it all... Video Podcast: https://youtu.be/u4XirePJKfg MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, we'll be discussing how sirtuins play their role in mitochondrial health and insulin resistance. Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432223/ Video Podcast: https://youtu.be/M9INrzrfsu4 0:00 - Introduction 3:10 - Diabetes Background 8:30 - Mitochondria Background 13:33 - Mitochondria & Insulin Resistance 20:33 - Sirtuins 43:40 - Conclusions/Take Aways MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, I summarize the content from a brand new scientific review that discusses the difference between creatine supplementation for the brain vs the rest of the body, as well as a possible alternative. Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7916590/ Video Podcast: https://youtu.be/gltKZA6JQr0 MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, I cover a study sent to me by a subscriber wherein the researchers discuss a new model for understanding metabolism through their self titled 'Compensation Hypothesis'. Study: https://www.sciencedirect.com/science/article/pii/S0960982221011209 Video Podcast: https://youtu.be/O7TY-HMZkKA MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this podcast, I'll be detailing a brand new study deeply investigating the decline in metabolism with age. Study: https://science.sciencemag.org/content/373/6556/808 Video Podcast: https://youtu.be/cXHxl8dPqG0 MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 0:00 - Introduction 6:02 - Metabolism over the Lifespan 13:35 - 2 Factors that lead to Metabolism Decline? 23:58 - Conclusion/Take Aways

In this episode, we'll dive into two very similar studies trying to distinguish the effect of the ketogenic diet on cholesterol, blood sugar, insulin, and blood fats (triglycerides). Video Podcast: https://youtu.be/yx2OuoMZBFg Study A: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8001988/pdf/nutrients-13-00814.pdf Study B: https://pubmed.ncbi.nlm.nih.gov/12949361/ 0:00 - Introduction 3:40 - Study Design 12:18 - Keto on Cholesterol 20:07 - Keto on Blood Sugar & Insulin 22:25 - Keto on Triglycerides 24:05 - Discussing the Results 37:48 - Conclusions/Take Aways MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, we'll dissect a study wherein the researchers attempt to find out how an unrestricted intermittent fasting protocol works for overweight individuals in aspects of weight, muscle, metabolism, and cardiovascular outcomes like cholesterol, blood sugar, insulin, and so on. Video Podcast: https://youtu.be/TjEKr7ysbfI Study: https://pubmed.ncbi.nlm.nih.gov/32986097/ MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 0:00 - Introduction 5:33 - Study Design 7:26 - Could they Stick to IF? 9:22 - Individual Weight Loss 11:16 - Total Weight Loss 14:40 - Body Composition (Muscle, Fat, etc.) 21:19 - Metabolism 23:25 - Blood Sugar, Insulin, Cholesterol, etc. 26:31 - Conclusions/Take Aways

This week, I return by simply answering questions you guys sent me on Instagram and YouTube. MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6 0:00 - Introduction 2:35 - Thank you 5:25 - Limited Protein Absorption 8:04 - Protein on Lifespan 12:09 - Ideal Body Fat for Testosterone 14:25 - Threshold that Muscle Stops Protein Synthesis 17:40 - Creatine Bloat 20:48 - Origin of the Virus

In this episode, I cover a scientific review on the literature of protein for muscle growth. We'll be covering protein total amount, timing, type, differences in men and women, aging, and more. Enjoy. Video Podcast: https://youtu.be/7h-kLKmknEo Scientific Review: https://link.springer.com/article/10.1007/s40279-019-01053-5 MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, we investigate how elevated blood fats change how our mitochondria "behave" and its affect on autophagy. Video Podcast: https://youtu.be/g6JJzVkYM7I Study: https://www.sciencedirect.com/science/article/abs/pii/S0026049521001037 MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this podcast, I dive deeper into yet another study comparing the ketogenic diet for blood cholesterol, with the added bonus of briefly touching on insulin sensitivity. In this episode, we start to recognize the key difference between a healthy ketogenic diet and an unhealthy ketogenic diet. Study: https://pubmed.ncbi.nlm.nih.gov/15070924/ Video Podcast: https://youtu.be/KEcyW496KGA MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, we'll be going again into the ketogenic diet, but the context hath changed as the people being tested are healthy and young, non-overweight, unlike previous studies. There are some other caveats, as well, that we'll go into, so buckle up and let's dive in. Study: https://pubmed.ncbi.nlm.nih.gov/30408717/ Video Podcast: https://youtu.be/bX1cax3zvfQ MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, we dive into a study looking at how 16 hour intermittent fasting affects a variety of health outcomes when paired with resistance training in non-beginner lifters. Study: https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-1044-0 Video Podcast: https://youtu.be/2B99DJwPMCk MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, the 'keto hater' takes on a study that simply investigates the effects from the ketogenic diet in bodyweight, cholesterol, and blood sugar in people who are overweight. Study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2716748/pdf/ecc09200.pdf Video Podcast: https://youtu.be/bsH1qubGSB8 MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6

In this episode, we'll be beginning our look at senescent cells, how and why they occur, as well as the main drivers of senescence in aging and disease. Video Podcast: https://youtu.be/NcBpJv5WIhY Scientific Review: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748990/pdf/JCB_201708092.pdf MY BOOKS, COURSES, VIDEO REQUESTS, & CONSULTING - 'Understanding Creatine' Book: https://bit.ly/31GxkSN - Hire Me: https://bit.ly/3dmUl2H - Content Requests: https://bit.ly/2QOVHLX SUBSCRIBE TO OTHER SOURCES OF MY CONTENT [FREE] - Instagram (@Physionic_PhD): http://bit.ly/2OBFe7i - Facebook (Physionic): http://bit.ly/2PlIOaB - Twitter (@PhysionicPhD): http://bit.ly/2POhuBs - Email List: http://bit.ly/2AXIzK6