Podcasts about Testosterone

Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman combines cutting-edge medical advancements with holistic lifestyle strategies to help men optimize testosterone, sexual health, and reproductive performance at every age. Together, Dave and Dr. Houman tear through the myths, the bad science, and the outdated medical dogma around testosterone, erectile function, fertility, and male sexual health. They cover everything from why testosterone levels have collapsed in a single generation, to the real story behind the FDA black box warning, to practical protocols for men who want to optimize without sacrificing fertility. This is the masterclass on men's health that no one else is having on record. This is essential listening for anyone serious about biohacking, longevity, human performance, hormone optimization, brain optimization, anti-aging, functional medicine, mitochondria, and Smarter Not Harder approaches to male health. You'll Learn: Why testosterone levels in 40-year-old men are 30 percent lower than their fathers and what is driving the collapse How low testosterone connects to anxiety, depression, high cholesterol, blood sugar dysregulation, and all-cause mortality risk The truth about the original testosterone and heart attack study and why it still has not been retracted How to preserve fertility while on TRT using Clomid, enclomiphene, and HCG Why daily low-dose Cialis is one of the cheapest and most effective longevity drugs available What shockwave therapy, PRP, exosomes, and Botox injections actually do for erectile function How red light therapy at 660 and 850 nanometers supports testosterone production and nocturnal erections The supplement stack including ashwagandha, tongkat ali, fadogia agrestis, and creatine that supports healthy hormone levels Why porn-induced ED is epidemic in young men and how to reverse it How PT-141 and peptides fit into a complete male optimization protocol Thank you to our sponsors! Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: testosterone, low testosterone, TRT, testosterone replacement therapy, male fertility, erectile dysfunction, ED, men's health, sexual health, hormone optimization, Dave Asprey, biohacking, longevity, anti-aging, human performance, Dr. Justin Houman, Cedars-Sinai, urologist, shockwave therapy, PRP, exosomes, Botox penis, red light therapy, nitric oxide, Cialis, tadalafil, Viagra, sildenafil, PT-141, Melanotan, peptides, ashwagandha, tongkat ali, fadogia agrestis, creatine, Danger Coffee, Smarter Not Harder, Kyzatrex, clomid, enclomiphene, HCG, prolactin, cabergoline, porn-induced ED, refractory period, fertility, sperm health, spermatogenesis, FSH, LH, estrogen, aromatization, functional medicine, supplements, mitochondria, circadian rhythm, sleep optimization, cortisol, microplastics, inflammation, cardiovascular health, dementia, all-cause mortality, nocturnal erections, penile health, male optimization Resources: • Learn More About Dr. Houman's Work At: https://houmanmd.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Introduction 01:15 – Low Testosterone Epidemic 04:23 – Ejaculation & Testosterone 07:30 – Refractory Period & Aging 09:58 – Porn-Induced ED 11:09 – Cabergoline & Prolactin Management 12:42 – Oral Testosterone 13:24 – Testosterone Target Levels 16:46 – Supplements for Testosterone 18:46 – Anxiety-Based ED 26:23 – Penis Enhancement Options 27:37 – Shockwave Therapy 28:57 – Cialis for Longevity 29:56 – Fat & Filler Injections 34:50 – Pre-Sex Optimization 40:13 – Red Light Therapy 42:18 – Heat & Cold for Testosterone 43:35 – Underwear & Microplastics 44:58 – Testosterone & Fertility 49:15 – HCG & Preserving Fertility 52:00 – Testosterone Dosing Timing 53:22 – Creatine & Mitochondrial Health 55:20 – Overtraining Effects 56:24 – Peptides (PT-141) 59:08 – Optimal Diet for Fertility See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Kim Brockenbrough: https://www.cardiavision.com/https://www.linkedin.com/in/kimberly-brockenbrough-md-1b321a123/https://www.instagram.com/kimbromd?ighsh=YjVpcDcwdHA3ejVvYour calcium score came back zero. You're in the clear, right? Not so fast.In this episode, Optispan Clinical Director Dr. Nicki Byrne sits down with Dr. Kim Brockenbrough, board-certified cardiovascular radiologist, 25-year veteran of vascular imaging, and CEO of CardiaVision, for a conversation that challenges one of the most common assumptions in preventive cardiology.If you care about cardiovascular longevity, and you should, because heart disease remains the leading killer, this is the imaging conversation you didn't know you needed.Timestamps:00:00 — Cold open: The 48-year-old runner with an 80% blockage and a zero calcium score00:54 — Dr. Nicki Byrne introduces Dr. Kim Brockenbrough & CardiaVision01:45 — Dr. Brockenbrough's background: 25 years of vascular imaging02:35 — Cardiovascular disease through a longevity lens: imaging vs. labs vs. functional testing03:24 — The lifecycle of plaque: from fatty deposits to rupture and heart attack04:21 — Why soft plaque is more dangerous than calcified plaque (SCOT-HEART 2020)05:14 — How calcium scores are used in clinical practice — and where they fall short06:18 — The only way to see soft plaque non-invasively: coronary CT angiography (CCTA)07:08 — Which populations are most at risk of a false sense of security from calcium scoring08:03 — What a CCTA can tell you that a calcium score can't09:43 — How often should patients follow up with repeat scans?10:28 — Higher vs. lower dose radiation protocols — and why Dr. Brockenbrough chooses higher dose11:17 — Risks of CCTA: contrast reactions, kidney considerations12:15 — Stress tests vs. CCTA: why a negative stress test is a very low bar13:21 — Soft plaque that isn't flow-limiting: small emboli, dementia, and congestive heart failure15:36 — Medications that reverse plaque: statins, PCSK9 inhibitors, and the LOCATE trial16:23 — LDL reduction and plaque regression: what the data shows17:08 — High-intensity statins vs. Repatha — tolerability, efficacy, and the price drop18:27 — When OptiSpan reaches for PCSK9 inhibitors: ApoB, LDL, Lp(a), ApoE4, and significant disease19:22 — Why a rising calcium score on a statin is exactly what you want to see20:25 — AI plaque quantification tools: promise, limitations, and validation concerns22:54 — Has AI ever changed Dr. Brockenbrough's read? A real-world case23:40 — FFR-CT, the ISCHEMIA trial, and why stenting asymptomatic patients is no longer standard of care25:25 — The future of cardiac imaging and the case for universal CCTA screening26:52 — The patient experience: what to expect at a CardiaVision CCTA appointment28:18 — Why seeing soft plaque changes patient behavior — the power of treating disease, not numbers29:49 — Bridging the gap between longevity medicine and traditional cardiology33:11 — Testosterone, the TRAVERSE trial, and what you should know about your coronaries first35:41 — What causes coronary artery disease beyond cholesterol: sugar, inflammation, gum disease37:07 — Image walkthrough: soft plaque vs. calcified plaque on a real CCTA41:36 — Where to find Dr. Brockenbrough and CardiaVision

In this episode, Luke sits down with Shalin Shah, CEO of Marius Pharmaceuticals, to unpack the truth about testosterone. They explore the science, debunk common myths, and discuss innovative solutions designed to make hormone therapy more accessible and scalable. From lifestyle factors lowering testosterone levels to the growing importance of female hormone health, this conversation separates evidence from online noise and empowers listeners to take control of their health. What We Cover • The real impact of low testosterone in men and women• Why free testosterone and SHBG testing matters• Myths vs facts around testosterone therapy and steroids• Environmental factors, stress, and microplastics affecting hormones• The shift from injections to oral testosterone solutions• How to legally and safely access therapy• Practical first steps to optimize hormone health Resources Mentioned KYZATREX Oral Testosterone Capsuleshttps://www.kyzatrex.com/ The Testosterone Projecthttps://testosteroneproject.com/ Marius Pharmaceuticalshttps://mariuspharma.com/ Book Reference:Testosterone: Action, Deficiency, Substitution by Eberhard Nieschlag and Hermann M. Behre Connect with Shalin Shah Instagram: https://www.instagram.com/themetabolicceo/Website: https://mariuspharma.com/team/shalin-y-shah/ Disclaimer:This episode is for educational purposes only and is not medical advice. Always consult a qualified healthcare professional before beginning any hormone therapy or medical treatment. Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

In this episode, I share a personal story I have never told in detail before. It begins in my early 50s after separating from my husband of 25 years and rediscovering sex in a new relationship. My libido was strong, my excitement was back, but something unexpected started happening. I suddenly could not orgasm.That experience sent me down a path that completely changed how I understand hormones, sexual health, and midlife sexuality. I talk about the appointment at a sexual medicine clinic that opened my eyes to the role of clitoral stimulation, vibrators, and something most women never hear about. Testosterone.I explain how low testosterone affected my ability to orgasm, how doctors evaluate hormone therapy for women, and why testosterone treatment must be carefully monitored. I also share the surprising moment in a doctor's office that changed my relationship with pleasure forever.If your desire is still there but your body does not respond the way it used to, this episode explains why that can happen and what options exist.In this episode: 00:00 Why I decided to share my testosterone story01:02 Separating from my husband and rediscovering sex02:12 When orgasms suddenly became difficult03:15 The doctor visit that changed everything04:28 What I learned about clitoral stimulation05:20 Why women also have testosterone06:23 How doctors test hormone levels07:30 The vibrator moment that shocked me08:36 How testosterone therapy works for women09:33 Why some doctors avoid testosterone pellets10:31 How I take testosterone today11:25 The risks of taking too much testosterone12:27 Why testosterone has been a game changer for me13:00 My advice if you are struggling with sexual changesWant a deeper look? Watch the full episode on YouTube for a more visual experience of today's discussion. This episode is best enjoyed on video—don't miss out!Karen Bigman, a Sexual Health Alliance Certified Sex Educator, Life, and Menopause Coach, tackles the often-taboo subject of sexuality with a straightforward and candid approach. We explore the intricacies of sex during perimenopause, post-menopause, and andropause, offering insights and support for all those experiencing these transformative phases.This podcast is not intended to give medical advice. Karen Bigman is not a medical professional. For any medical questions or issues, please visit your licensed medical provider.Looking for some fresh perspective on sex in midlife? You can find me here:Email: karen@taboototruth.comWebsite: https://www.taboototruth.com/Instagram: https://www.instagram.com/taboototruthYouTube: https://www.youtube.com/@taboototruthpodcastKaren Bigman, a Sexual Health Alliance Certified Sex Educator, Life, and Menopause Coach, tackles the often-taboo subject of sexuality with a straightforward and candid approach. We explore the intricacies of sex during perimenopause, post-menopause, and andropause, offering insights and support for all those experiencing these transformative phases.This podcast is not intended to give medical advice. Karen Bigman is not a medical professional. For any medical questions or issues, please visit your licensed medical provider.Looking for some fresh perspective on sex in midlife? You can find me here:Email: karen@taboototruth.comWebsite: https://www.taboototruth.com/Instagram: https://www.instagram.com/taboototruthYouTube: https://www.youtube.com/@taboototruthpodcastSubstack: https://karenbigman.substack.comTake control of your pleasure with my Pleasure Playbook, filled with tips to help you connect with your body and enhance intimacy. Download it now at www.taboototruth.com/pleasureplaybook.LINKS, EXCLUSIVE VIP DISCOUNTS, COURSES & FREEBIES

What if some of the most trusted ideas about cholesterol, heart disease, grains, fat, and even exercise were never as solid as we were told—and the consequences are now showing up in weaker muscles, damaged guts, and rising chronic disease? Cardiologist and #1 New York Times bestselling author Dr. William Davis has spent more than a decade challenging the foundations of modern nutrition—from cholesterol myths to the hidden dangers of modern wheat. In this episode, we uncover what today's wheat does to the body that ancient wheat never did, why even one weekly “cheat meal” can disrupt inflammation and cholesterol for weeks, and what your doctor may not be telling you about statins, muscle loss, and the true drivers of heart disease. Watch The Dr. Josh Axe Show every Monday & Thursday on YouTube: https://www.youtube.com/@drjoshaxe?sub_confirmation=1 

Episode #207 of the PricePlow Podcast brings together Keely Johnson, VP of Sales and Marketing at Arjuna Natural, and Dr. Jessie Cavanaugh of Nutraceuticals Research Institute for a deep dive into cortisol science and ashwagandha research methodology. Jessie, a Harvard Medical School Clinical Scholars Training Program alumna, just completed what she describes as the first botanical study ever to use timestamped cortisol awakening response (CAR) measurements. The subject: Shoden ashwagandha at 60mg, in a three-arm trial with Shoden, Shoden-R, and placebo. Also joining for her podcast debut is Victoria Johnson, registered nurse and familiar face from the PricePlow Instagram channel, who brings a hands-on clinical angle to the conversation. The episode covers what separates quality nutraceutical research from noise, why cortisol balance matters far more than cortisol suppression, and where Shoden is headed: into beverages, pre-workouts, and potentially women’s multivitamins. If you caught Keely on Episode #171 covering the Shoden revolution, this is the scientific sequel. Before diving in, subscribe to the PricePlow Podcast on your favorite platform and sign up for Arjuna Natural news alerts on PricePlow so you’ll know the moment the CAR study publishes. https://blog.priceplow.com/podcast/cortisol-awakening-response-shoden-207 Video: Shoden Cortisol Awakening Response Research with Jessie Cavanaugh https://www.youtube.com/watch?v=vEDJdOv4B14 Detailed Show Notes: Keely Johnson, Jessie Cavanaugh, and Victoria Johnson on Cortisol, Stress, and Shoden (0:00) – Introductions (1:45) – Jessie Cavanaugh’s Background (3:00) – What Makes Good Nutraceutical Research (5:30) – Recruiting the Right Study Population (7:00) – Acute vs. Chronic Stress (11:15) – Cortisol: Beyond “The Stress Hormone” (13:45) – The Cortisol Awakening Response (18:00) – Study Protocol & Lifestyle Controls (20:00) – The Three-Arm Shoden Study (23:30) – Decentralized Studies & Participant Compliance (27:15) – Study Outcomes & the Blunted Cortisol Surge (31:00) – Formulating with Shoden: Beyond Calm (34:00) – Shoden-R in Functional Beverages (37:00) – Cortisol Balance, Testosterone & Consistency (40:30) – Sleep Hygiene, Shift Work & Daily Habits (44:30) – What’s Next: Menopause Research, Publication & The Book Where to Follow and Learn More Connect with the Guests LinkedIn: Keely Johnson – VP of Sales and Marketing, Arjuna Natural LinkedIn: Jessie Cavanaugh – Founder, Nutraceuticals Research Institute Instagram: @primovictoria_rn – Victoria Johnson, RN and PricePlow Instagram team Arjuna Natural Nutraceuticals Research Institute PricePlow Resources …… Read more on the PricePlow Blog

Discover why the fitness routine that used to work for you has stopped delivering results after 40. This episode breaks down the real science behind hormonal changes, metabolism shifts, and recovery needs that make your old approach ineffective. Learn what your body actually needs now and how to work with your biology instead of against it for lasting results.DETAILED SHOW NOTES:[00:00 - 00:30] IntroductionWelcome to Fit Over 40 - The PodcastToday's topic: Why your old workout routine stopped working[00:30 - 01:15] The Familiar FrustrationThe treadmill that used to work doesn't anymoreCalorie cutting used to drop weight quicklySame effort, no results (or going backwards)[01:15 - 01:45] Validation of the StruggleYou're not broken, lazy, or lacking willpowerYour body has changed - this is normal[01:45 - 02:30] The Real Reason: Hormonal ShiftsEstrogen decline (even before menopause)Testosterone drops affecting muscle buildingElevated cortisol from chronic stressThese are biological facts, not excuses[02:30 - 03:00] Metabolism Reality Check1% muscle mass loss per year after 40Muscle burns more calories than fatLess muscle = slower metabolic rate[03:00 - 03:30] Why Cardio Stops WorkingBody adaptation to familiar routinesExcessive cardio increases cortisolPromotes fat storage around the middle[03:30 - 04:00] The Stress FactorHigher stress levels in your 40s+Body can't distinguish stress typesSame response: fat storage and weight retention[04:00 - 04:30] Recovery Takes LongerSlower bounce-back from intense workoutsOvertraining keeps cortisol highInadequate recovery stalls progress[04:30 - 05:00] The Calorie Cutting Trap"Eat less, exercise more" backfires after 40Severe restriction signals famine modeResults in fatigue, hunger, and frustration[05:00 - 05:30] What Your Body Needs NowStrength training becomes non-negotiableFocus on preserving muscle massMuscle is your metabolic currency[05:30 - 06:00] The Strength Training SolutionProgressive resistance is keyGradually increase weight, reps, or difficultyBody responds to new challenges[06:00 - 06:30] Protein Becomes CriticalIncreased protein needs after 40Body less efficient at protein utilizationMost women aren't eating enough[06:30 - 07:00] Recovery Is Part of the PlanRest days are growth daysSleep disrupts hunger and fat storage hormonesRecovery is when muscles repair and strengthen[07:00] Closing ThoughtsWork with your biology, not against itYou're not starting over - you're leveling upKEY TAKEAWAYS:✓ Hormonal changes after 40 affect metabolism and fat storage✓ Muscle loss (1% per year) slows metabolic rate✓ Excessive cardio can increase cortisol and promote weight gain✓ Strength training becomes essential for muscle preservation✓ Protein needs increase with age✓ Recovery and sleep are crucial for results✓ Success metrics should include energy, strength, and how you feelRESOURCES:Visit https://fatlossbuffalo.com for more fitness strategies designed specifically for women over 40.

In this powerful and deeply honest episode of Please Me!, host Eve welcomes Brent Dowlen, relationship and personal development coach, podcast host, and creator behind multiple shows including Driven To Thrive Broadcast and Dad Hat Shenanigans. Together, they unpack the rarely discussed realities of men's sexual health, including performance anxiety, shame, stress, and identity — and how these factors deeply impact intimacy, relationships, and mental health. Brent shares candid personal experiences with erectile dysfunction caused by stress and exhaustion, shedding light on how strongly many men tie sexual performance to masculinity and self-worth. The conversation explores how fear, shame, and societal expectations can quickly turn sex from a source of connection into a source of anxiety — and what men (and their partners) can do to interrupt that cycle. This episode also dives into foundational habits for long-term sexual health, including sleep, nutrition, hydration, exercise, stress management, and honest self-assessment. Eve and Brent address the men's mental health and loneliness epidemic, the outdated “playbook” men are still handed, and why vulnerability is often encouraged in theory but punished in practice. The episode concludes with a realistic and educational role-play conversation, modeling how couples can communicate desires, boundaries, fantasies, and consent — proving that healthy sexual communication can be awkward, playful, respectful, and deeply connecting. Men's sexual performance anxiety and identity Erectile dysfunction, stress, and exhaustion Shame and fear surrounding sexual health issues When men should seek support for sexual health concerns Sleep, hydration, nutrition, and cardiovascular health for sexual wellness Testosterone, exercise, and healthy fats Men's mental health crisis and loneliness epidemic Why traditional therapy often misses men Masculinity, vulnerability, and societal expectations Initiating intimacy and feeling desired as a man Power dynamics, submission, and stress relief in the bedroom How to talk to your partner about fantasies and boundaries Consent, communication, and curiosity in long-term relationships Whole-Foods, Plant-Based Nutrition | Juice Plus+https://www.juiceplus.com How to Connect with Brent Dowl Website https://purposedrivenmen.com Connect with Eve & Please Me! Website:https://pleaseme.online Social Media & Contact:https://pleaseme.online/contacts Substack Newsletter:https://pleaseme.substack.com Patreon — Ad-Free Episodes & Bonus Content:https://patreon.com/PleaseMePodcast Be a Guest on Please Me!:https://www.podmatch.com/hostdetailpreview Learn more about your ad choices. Visit megaphone.fm/adchoices

If you've ever been dismissed, minimized, or given outdated advice about menopause — this video is for you. Every week in my clinic, I hear the same myths repeated to intelligent, capable women who simply want to feel like themselves again. Unfortunately, misinformation around menopause and hormone therapy is still everywhere — even inside medical offices. Today, I'm addressing 10 of the most common (and harmful) things women are told about menopause — and explaining what the science actually says. We'll discuss: • “Hormone replacement is dangerous. Just take birth control pills.” • “You're only 42 — you're too young for menopause.” • “Your labs are normal, so it can't be menopause.” • “You must wait a full year after your last period to start hormones.” • “You can't start hormones after 60 — or you must stop at 60.” • “Hormones aren't FDA-approved for heart disease or Alzheimer's, so they don't help.” • “You can't take hormones if you have a family history of breast cancer.” • “Testosterone is only for men.” • “Testosterone is just for libido.” • “You can never take estrogen or progesterone after breast cancer.” Menopause care is nuanced. It's individualized. And it should be rooted in evidence — not fear. I'll walk you through what we know today about menopausal hormone therapy, testosterone therapy for women, timing, safety, and why so many women are still being told outdated information. You deserve clarity. You deserve options. And you deserve a provider who understands midlife physiology. Further Reading & Trusted Resources The Menopause Society www.menopause.org Dr. Louise Newson www.drlouisenewson.co.uk Instagram: @menopause_doctor Study referenced in this video: Effect of transdermal testosterone therapy on mood and cognitive symptoms in peri- and postmenopausal women: a pilot study Full paper: http://bit.ly/4tWR9S5 If this video helped you, please share it with a woman who needs better information. Subscribe for evidence-based education on midlife health, hormone optimization, and longevity. Because menopause is not the end of vitality — it's the beginning of informed power.

Over the course of a woman's life, their hormone levels change in ways that can have a real impact on mood and daily routine. For example, it's pretty well known that libido tends to decline at the time a woman is premenopausal. Now to address that loss of libido, an increasing number of women have turned to testosterone, or T for short, to rekindle their sexual desire. And if you believe accounts on social media, it does actually work, at least some of the time! Isn't that a male hormone? Is it really as effective as people say then? Is testosterone an authorised treatment then? What are the health risks then? In under 3 minutes, we answer your questions! To listen to the latest episodes, click here: Do women really watch less porn? How does eldest daughter syndrome affect some women? Can women really get a core-gasm from exercise? A Bababam Originals podcast written and realised by Joseph Chance. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.

Please listen in, take notes and ask questions!?Takeaways:Dillan stopped testosterone therapy due to health concerns.Transitioning to Ways2Well improved his health management experience.Blood work revealed increased testosterone but also elevated estrogen.High liver enzymes prompted a reevaluation of his health.Stress and gut health are critical factors in overall wellness.Dillan is focusing on stabilizing his body and gut health.Dietary adjustments include more easily digestible foods.Health optimization requires a balanced approach, not just supplements.Tracking health data is essential for informed decisions.Advocating for oneself is crucial in health management.Keywords:testosterone, health journey, hormone balance, liver health, gut health, nutrition, wellness, stress management, optimization, health podcast

Why settle for normal when we the target should be peak human health optimization, what I call superhuman? With the billions being put into the biotech industry, wearables, more access to all sorts of techniques, and now the unimaginable power of AI, it truly does seem the limits of health at the moment are boundless. That's the world my guest Dr Sanjeev Goel inhabits, and today we discuss our clinical experience and what we see working for human health and mental performance.Dr. Sanjeev Goel is a Canadian physician, speaker, and longevity expert widely known as “The Happiness and Longevity MD.”, his career spans over five decades and includes remote medical service in Himalayan communities as well as teaching mindfulness and resilience to healthcare professionals. His work focuses on helping individuals reduce burnout, slow biological aging, and improve mental, physical, and emotional wellbeing through evidence-based, nature-aligned practices. A serious Lyme-like illness in 2019 deepened his commitment to restorative health and self-directed healing, shaping his approach today. Dr. Goel emphasizes that happiness and longevity are not opposing goals, but outcomes of a life lived in biological and personal alignment.Get 10% off peptides and supplements at PeakHuman using code MADETOTHRIVE10Contact: Website - https://www.sanjeevgoel.com/Website - https://www.peakhuman.caJoin us as we explore:Improving sleep quality with TMS and new targeted pharmaceuticals,  the wellness hormone, GLP1s for cravings and addiction and the best data points to test for cognitive decline and mental performance.PeakHuman, the Peak 5 RI process, HBOT, plasmapheresis and AI.Testosterone aromatization, the right testosterone to estrogen ratio, TRT, DHT and why it's never too early in life to start tracking your data.The best diagnostic tests to determine biological age.Mentions:Product - ExoMind, https://bodybybtl.com/solutions/exomind/ Diagnostic - TrueAge, https://shop.trudiagnostic.com/products/truage-complete-epigenetic-collectionTreatment - Plasmapheresis, https://en.wikipedia.org/wiki/Plasmapheresis Support the showFollow Steve's socials: Instagram | LinkedIn | YouTube | Facebook | Twitter | TikTokSupport the show on Patreon:As much as we love doing it, there are costs involved and any contribution will allow us to keep going and keep finding the best guests in the world to share their health expertise with you. I'd be grateful and feel so blessed by your support: https://www.patreon.com/MadeToThriveShowSend me a WhatsApp to +27 64 871 0308. Disclaimer: Please see the link for our disclaimer policy for all of our content: https://madetothrive.co.za/terms-and-conditions-and-privacy-policy/

It's How I live well time! Andrea will be joined by experts to discuss ways you can improve your life…This week, Andrea is joined by Endocrinologist Professor Mary Ryan to talk all things testosterone.

Perimenopause plus ADHD can feel like someone yanked the power cord out of your brain. Low mood, no energy, libido gone, shorter cycles, cutting back work and the gym, and thinking, “WTF is wrong with me?!”In this episode, I am sharing 6 things I have learned about ADHD and perimenopause, including my own hormone testing journey and what the research is starting to show.We talk about:The new research showing women with ADHD often experience Perimenopause symptoms earlier & more severe! Why estrogen matters SO much for ADHD brainsWhat I learned from running my own blood tests (Why timing matters when testing estrogen)Testosterone cream, energy and mood & why it is usually added on top of an already solid estrogen planAdvocating for yourself in the medical systemThe perimenopause symptoms no one told me about… Including changes in body odour, itchy skin, formication, and phantom smellsImportant note: I am not a medical professional. This episode is based on my own experience and the research I have read, and it is not a substitute for medical advice. Please talk with your GP or menopause specialist about your specific situation.If you want to go deeper on hormones and ADHD, check out:Episode 21 Women With ADHDEpisode 35 Hormones & ADHDEpisode 54 Hormones, Perimenopause & ADHD with Dr Samantha NewmanEpisode 137 5 Things to understand about ADHD & Perimenopause LINKS TO OTHER GOOD SH*T:*Join Adulting with ADHD your ADHD toolbox & everything you need to work with your brain*Get our ADHD Coach in your pocket! + the ADHD Goal Setting Workbook (life planner tool)*12 Things I wished my Doctor had told me about Adult ADHD*Find out if you might be living with ADHD - Download Symptoms List*Check out Courses & Coaching with Xena*Learn, Inspire, Share & Connect inside our Facebook Community *Come hang out with me on Instagram!

Jess Wallace - adventure host, travel lover, online business manager, teacher turned entrepreneur and promoter of living a big, authentic + full life is back on the pod!  She specializes in helping female entrepreneurs thrive in their businesses.  Jess and Danielle host all women adventure trips to create a space for women to connect, see the world together, make lifelong friends, and unlock core memories.  We love getting women outside, connecting, adventuring, betting on themselves, taking up space, doing it scared, building confidence, living big + chasing magic. In this episode, we chat about:  The personal announcement I've been sitting on (and why it matters) Why women need testosterone, too, especially in perimenopause and beyond How to find HRT in Utah, and what to look for in a hormone provider Supporting small businesses: why your referrals and shares actually matter Facts don't care about your feelings. Even when it comes to health and nutrition. Internet meltdowns vs real activism in wellness spaces Why "food noise" might actually be under-eating and poor nourishment The ongoing issues with GLP-1 medications and metabolic health Behind the scenes of building a scrappy health business Join us in Patagonia November 2026   Follow Empowered Medicine Schedule a Consult Call with Danielle Join the adventure party in Patagonia with Jess + Danielle Learn more about working with me  Shop my masterclasses (learn more in 60-90 minutes than years of dr appointments) Follow me on IG Follow Empowered Mind + Body on IG  Follow Jess on IG 

Midlife is a time for all women to write their own unique script. Elaine showed us her power moves and inspires us all to live boldly. Societal scripts of winding down are just that --outdated scripts. Live your dreams, put yourself out there and rewrite the narrative. Just know that we have all the tricks for redefining what is possible at any age. 

Send a textThyroid Talk with Dr. Angela Mazza, DOShow Notes Episode 47; Recorded: 1-20-2026Small Molecules, Big Impact: Peptides for Thyroid HealthHost: Dr. Angela Mazza, DOCo-host: Dawn Sheffield I'm Dr. Angela Mazza, D.O., a thyroid, endocrine, and metabolism specialist with a private practice in Central Florida.  My goal for this podcast is to define and demystify the thyroid gland, and thyroid-related medical conditions.  By providing information in an easy-to-understand format, we hope to help patients better understand the ways in which their bodies work, and to help them thrive.  My goal is to help us live more fulfilling lives by taking control of our health, to feel our best.  Here's some of what we covered in episode 47 (Small Molecules, Big Impact: Peptides for Thyroid Health), not necessarily in this order: ·        What are peptides and what work do they do?·        How peptides help with cellular dysfunction.·        How peptides are delivered into the body.·        Which peptides are often used for thyroid patients--and why.·        Peptides may help when a person's lab reports look better, but they do not feel better.·        Peptide therapy is an investment in cellular health.  Costs can vary depending on various factors.·        Peptides bring hope, and hope is the future of endocrine care.·        And best of all we learned that we CAN impact our thyroid health! My book, Thyroid Talk: An Integrative Guide to Optimal Thyroid Health, is available on Amazon.  For information on the related Webinar and online master course, see thrivethyroid.com.  Or forward your name and email to thyroidtalk.mazza@gmail.com or to our website: metaboliccenterforwellness.com  The webinar coordinates with the online master class.  The master class has modules that cover topics like diagnosis of thyroid issues, personalized treatment, gut healing, and much more--plus some bonuses. Visit the Wellness Store at metaboliccenterforwellness.com regarding supplements mentioned in various episodes of this podcast.  Please stay in touch!  Send your comments, show ideas, and questions to thyroidtalk.mazza@gmail.com  We may disclose your general location on air (the city or town, for example), but we will not read your name nor your address on the show.  We reserve the right to edit your input as necessary.  See the website at metaboliccenterforwellness.com; our YouTube channel (Dr. Angela Mazza), Facebook, and Instagram.   The topic of our next episode, number 48, is Testosterone for Women.Citations, references, additional information:Mazza, A. Thyroid Talk: An Integrative Guide to Optimal Thyroid Health.  Available now on Amazon.Ask your healthcare provider about specific questions regarding your wellness.  This podcast is meant for educational purposes only.  Copyright 2026 Dr. Angela Mazza DO.  Thyroid Talk with Dr. Angela Mazza, DO.  All rights reserved.Check out our YouTube channel - Dr. Angela Mazza, our website at Metabolic Center for Wellness, our FaceBook and our Instagram page.

Understanding the science behind TRT for muscle weakness, from injections to oral options, and how lifestyle choices and recent research are reshaping treatment for low testosterone. Learn more at https://trtaustralia.com/types-of-trt-treatments/ TRT Australia City: Hurstville Address: 7–11 The Avenue Website: https://trtaustralia.com/x

Kingdom = government, dominion of a place; Tempting the wealthy; "King" story; Tithingmen; Taxing early Americans; Degeneration of the people; Rights and liberties; Roman republic; Jutes?; Julius Caesar; Testosterone and bravery; Stolen land?; Voter fraud?; Ruthless Indians; "Tithable"; Taking away your neighbor's property; What degenerates the people; "Commander-in-Chief" + "Principas Civitas" + "Apotheos"; Forms of government; Function of The Church; "Pseudo-capitalism"; Having sight; Cities of blood; Deut 17; Intra-brain hemispheric connections; Tongues?; Forcing contributions?; One-room schoolhouses; Strengthening community; Flaws in our thinking; Self-governance?; "Corban" of the Pharisees; Lady Godiva; Twice-robbed people; Sophistry; Human nature; Snares and traps; "Notes"; Repentance; Walking in the ways of Christ; Q: From Isabelle: Public school in NY - History taught; Altering history; Patrick Henry; Living in darkness; Inability to see truth; Genocide; Dividing the people; Benefit addiction; Caring for neighbors; No covetousness; Not to be like the government of the gentiles; Strive and persevere.

Hey Diabuddy thank you for listening to show, send me some positive vibes with your favorite part of this episode.Hormones don't get talked about enough in the Type 1 diabetes world — especially male hormones.In this live episode, I sit down with my good friend and colleague Type 1 Diabetic, registered dietitian and functional nutrition expert Kelly Schmidt to unpack testosterone, cortisol, thyroid health, sleep, labs, intimacy, and the systemic impact hormones have on blood sugar, energy, and quality of life.This conversation goes far beyond “low T.”This episode reinforces a powerful truth:Type 1 diabetes is not just a pancreas condition — it's a systems condition.If you've been feeling fatigued, burned out, low energy, low drive, or just “off,” this episode will give you language and direction for your next conversation with your healthcare team.Important Resources We Discussed:Magnesium Glycinate & Other ImpactfulLab Panels - interpreted with a t1d lens (Kelly reads the labs and then explains the results in great detail.)Kelly's Previous Episodes:Diabetes Vulnerabilities - #135Debunking Diabetes Detox Myths - Episode #130Manipulating Your Blood Sugars During The Female Cycle - Episode #123The 5-Pillars to Healthy Blood Sugars - Episode #119Gut Health w/T1D Dietitian - Episode #117Food Sensitivities - Episode #72The Expert Dietitian Series - Part 3 - Episode #44The Expert Dietitian Series - Part 2 - Episode #40The Expert Dietitian Series - Part 1 - Episode #35Why Is Nutrition Important in Diabetes? - Episode #9

Paige is activated and Hannah shares a life changing discovery. subscribe to our newsletterwatch on youtube Hosted on Acast. See acast.com/privacy for more information.

It's AMA time again, and this one goes deep.Alyson and I open the floor to your questions, and what unfolds is an honest, vulnerable exploration of self-love, self-worth, and the subtle ways we block ourselves from the lives we say we want. Inspired by a recent 13-hour healing journey, I share some powerful realizations about integrity, honoring myself, and the surprising gap between loving others and truly loving myself.We unpack what self-love actually looks like in practice—not just mirror affirmations, but identifying childhood imprints, dissolving shame, raising standards, and developing discernment in relationships and business. Alyson brings in her perspective on embodied self-respect, parts work, and Internal Family Systems, offering grounded tools for healing old patterns and integrating fractured aspects of ourselves.From there, we shift gears into a fun but revealing conversation about influence and inspiration. I break down some of my favorite podcasts, from countercultural voices and spiritual finance to music deep dives and consciousness explorations, and why challenging my own beliefs is a core part of my growth.We also touch on money, integrity, jealousy, and the tension between spirituality and wealth—exploring how to hold abundance without selling your soul.If you've ever struggled with self-worth, boundaries, or reconciling purpose with prosperity, this episode offers reflection, humor, and a few hard-earned insights from the trenches.Get the Animal Power book and deck, plus a free guided drumming shamanic journey to meet your power animal, at alysoncharles.com/animalpower.DISCLAIMER: This podcast is for educational purposes only and not intended for diagnosing or treating illnesses. The hosts disclaim responsibility for any adverse effects from using the information presented. Consult your healthcare provider before using referenced products. This podcast may include paid endorsements.THIS SHOW IS BROUGHT TO YOU BY:REAL PROVISIONS | Get a free bag of venison chips with your order at realprovisions.com/lukeLVLUP HEALTH | Get 15% off with code LUKE15 at lukestorey.com/lvlupLEELA QUANTUM TECH | Go to lukestorey.com/leelaq and use code LUKE10 for 10% off their product line.BIOPTIMIZERS | Visit bioptimizers.com/luke and use code LUKE15 to save 15%.MORE ABOUT THIS EPISODE:(00:00:00) The Master Key of Self-Love & Becoming an Honorable Human(00:42:11) The Podcasts That Shape My Thinking (And Challenge My Beliefs)(01:13:36) Mushrooms, Minimal Phones, & Nature's Testosterone(01:25:21) From Victimhood to Power: The Case for Radical Responsibility(01:39:19) Circumcision, Trauma, & the Fight for Bodily AutonomyResources:• Website: alysoncharles.com• Instagram: instagram.com/iamalysoncharles• Facebook: facebook.com/rockstarshaman• X: x.com/alysoncharles• TikTok: tiktok.com/@alysonoracle• YouTube: youtube.com/@alysonstorey• Shop all our merch designs at lukestoreymerch.com• Join me on Telegram: t.me/lukestorey

Big update! What happened to the dog Klein found wandering the streets near the studio yesterday? The job of finding the owner went to Ally after Jake, Johnny, Klein and Vanessa turned down the responsibility. You gotta listen to the full story, including a live call from the dog's owner! Michael from Evolve Anti-Aging came back to read the results of yesterday's Testosterone test, and you will not believe how it panned out. We have a new most masculine person on the show, and it's definitely not the person you'd expect. This person won their T amount in dollar form, and the person with the LOWEST t on the show won a new nickname! #joannie We also FINALLY got a payoff for Bathroom Interviews, a bit Kevin Ryder pitched to Klein two weeks ago. We listen to the audio with Ryder on the line and he pitches yet another bit to reboot next.

Half of men over 40 will experience erectile dysfunction.In this episode, I explain why ED is rarely only about sex. I walk you through what erections actually reveal about cardiovascular health, metabolic function, hormones, pelvic floor tension, and fertility.I break down why urologists call the penis a barometer of heart health. The blood vessels that support erections are smaller than the ones that support your heart and brain. That means they often show damage earlier. In many cases, ED appears years before a heart attack or stroke.I also talk about diabetes, high cholesterol, nitric oxide, testosterone shifts, excess body fat, and sperm quality after 40. We cover pelvic floor tension in men and why many men struggle with tight muscles, not weak ones.I share evidence informed tools some men use while they work on underlying health. These are not cures. They are supports.Most importantly, I reframe ED as information. Not shame. Not failure. A signal.In This Episode: 00:00 MaxPR From FirmTech And 15 Percent Off00:45 Why Erections Are About More Than Sex01:30 ED As An Early Health Signal02:20 Erections, Blood Flow, And Heart Risk03:15 Diabetes, Cholesterol, And Nitric Oxide04:00 Tracking Erections And Using Objective Data04:45 Wearable Devices And Pelvic Floor Support05:40 Pelvic Floor Tension In Men06:20 Medical Grade Pumps And Penile Health07:00 Fertility, Testosterone, And Lifestyle Factors07:40 The Real Risk Is Avoidance And SilenceWant a deeper look? Watch the full episode on YouTube for a more visual experience of today's discussion. This episode is best enjoyed on video—don't miss out!Karen Bigman, a Sexual Health Alliance Certified Sex Educator, Life, and Menopause Coach, tackles the often-taboo subject of sexuality with a straightforward and candid approach. We explore the intricacies of sex during perimenopause, post-menopause, and andropause, offering insights and support for all those experiencing these transformative phases.This podcast is not intended to give medical advice. Karen Bigman is not a medical professional. For any medical questions or issues, please visit your licensed medical provider.Looking for some fresh perspective on sex in midlife? You can find me here:Email: karen@taboototruth.comWebsite: https://www.taboototruth.com/Instagram: https://www.instagram.com/taboototruthYouTube: https://www.youtube.com/@taboototruthpodcastKaren Bigman, a Sexual Health Alliance Certified Sex Educator, Life, and Menopause Coach, tackles the often-taboo subject of sexuality with a straightforward and candid approach. We explore the intricacies of sex during perimenopause, post-menopause, and andropause, offering insights and support for all those experiencing these transformative phases.This podcast is not intended to give medical advice. Karen Bigman is not a medical professional. For any medical questions or issues, please visit your licensed medical provider.Looking for some fresh perspective on sex in midlife? You can find me here:Email: karen@taboototruth.comWebsite: https://www.taboototruth.com/Instagram: https://www.instagram.com/taboototruthYouTube: https://www.youtube.com/@taboototruthpodcastSubstack: https://karenbigman.substack.comTake control of your pleasure with my Pleasure Playbook, filled with tips to help you connect with your body and enhance intimacy. Download it now at www.taboototruth.com/pleasureplaybook.LINKS, EXCLUSIVE VIP DISCOUNTS, COURSES & FREEBIES⭕️ Save 15% off on the MaxPR using code TABOO15

Sexual medicine is underfunded, misunderstood, and often dismissed. But it's also one of the most collaborative fields in healthcare. Dr. Tami Rowen recaps this year's ISSWSH conference and what it revealed about where the field is heading.Dr. Rowen is the current president elect of ISSWSH and has been instrumental in shaping sexual medicine education and research. We recorded this right after the 2026 ISSWSH conference in Long Beach, which had almost 600 attendeesone of our biggest conferences yet.We discuss the standout research from the meeting, including award winning work on sexual function after gender-affirming hysterectomy and why most top abstracts focused on sexual pleasure rather than prevention. We talk about the reality of research funding in sexual medicine, why industry support creates conflicts of interest that look bigger than they are, and how lack of NIH funding means we have almost no treatment options for conditions like vulvodynia.We also dive into testosterone therapy why it's controversial, what the data actually shows versus what social media claims, and why Dr. Rowen doesn't treat hormone levels but rather treats individuals with specific goals. We discuss body image after breast cancer surgery, lymphedema's impact on sexual function, and why technoference is contributing to the lowest rates of sex we've ever seen.HighlightsISSWSH focuses on sexual pleasure and quality of life, not just prevention of pregnancy and STIs.Research funding for vulvodynia is $4 million annually versus $800 million for breast cancerthat's one grant versus hundreds.Testosterone therapy should treat symptoms and goals, not hormone levels or deficiencies.Body image and sexual function outcomes are significantly worse after mastectomy versus lumpectomy, even though cancer outcomes are equal.Technoference (technology interference) is contributing to historically low rates of sexual activity.If you're a clinician interested in sexual medicine, consider attending the ISSWSH Fall Course for foundational education and the annual meeting for cutting-edge research. If you're a patient navigating any issues and not currently getting help, know that there are practitioners out there who want to help you.Subscribe to the podcast and share this episode with anyone who wants to learn more about sexual medicine, menopause, or women's health education.Get in Touch with Dr. RowenWebsiteInstagramGet in Touch with Me: WebsiteInstagramYoutubeSubstackMentioned in this episode:GSM CollectiveThe GSM Collective - Chicago Boutique concierge gynecology practice Led by Dr. Sameena Rahman, specialist in sexual medicine & menopause Unrushed appointments in a beautiful, private setting Personalized care for women's health, hormones, and pelvic floor issues Multiple membership options available Ready for personalized women's healthcare? Visit our Chicago office today. GSM Collective

In this Huberman Lab Essentials episode, I explore how different wavelengths of light affect the human body and how light exposure can improve sleep quality, mood and daytime alertness while supporting healthy hormone regulation. I also discuss the therapeutic use of ultraviolet and infrared/red light for a wide variety of benefits, including improved skin health and offsetting age-related vision loss. I explain the biological mechanisms behind these light-based therapies and offer practical tools that listeners can use to improve both their mental and physical well-being. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman ROKA: https://roka.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Light (00:00:47) Physics of Light (00:01:57) Light & Body, Rods & Cones, Skin, Seasons & Melatonin (00:05:01) Melatonin Supplements?, Tool: Seasonal Sun Exposure (00:08:32) Sponsor: ROKA (00:09:47) Tool: Melatonin Levels & Reduce Night Light (00:10:31) Light, UVB, Skin Exposure, Testosterone & Estrogen, Fertility (00:13:54) UVB Light & Improved Pain Tolerance (00:16:10) Tool: Daily Sunlight Exposure Protocol; Blue Blockers (00:18:25) Sponsor: AG1 (00:19:16) Seasonal Affective Disorder (SAD), Year-Round Sunlight Exposure (00:21:24) Enhanced Immune Function & UVB Light, Tool: Winter Light Exposure (00:23:45) Light, Wound Healing, Hair & Nail Growth (00:25:11) Tool: Mood, Dopamine & Avoid Nighttime UVB Light (00:27:46) Sponsor: Function (00:29:25) Red Light Therapy, Infrared Light, Acne, Wound Healing & Scars; Mitochondria (00:33:06) Offset Age-Related Eyesight Decline, Red Light (00:37:22) Tool: Red Light Protocol, Frequency & Timing (00:40:02) Red Light for Shift Workers (00:41:42) Recap Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

The Testosterone Test full 775 Thu, 26 Feb 2026 16:24:00 +0000 pWoqt8l2w00FImJHGSLJ1o6tNSxAk4dx society & culture Klein/Ally Show: The Podcast society & culture The Testosterone Test Klein.Ally.Show on KROQ is more than just a "dynamic, irreverent morning radio show that mixes humor, pop culture, and unpredictable conversation with a heavy dose of realness." (but thanks for that quote anyway). Hosted by Klein, Ally, and a cast of weirdos (both on the team and from their audience), the show is known for its raw, offbeat style, offering a mix of sarcastic banter, candid interviews, and an unfiltered take on everything from culture to the chaos of everyday life. With a loyal, engaged fanbase and an addiction for pushing boundaries, the show delivers the perfect blend of humor and insight, all while keeping things fun, fresh, and sometimes a little bit illegal. 2024 © 2021 Audacy, Inc. Society & Culture False https://player.amperwavepodcasting.com?feed-link=https%3A%2F%2Frss.ampe

It was an exciting start to the morning when Klein came across a dog running across the street in a residential neighborhood. Klein stopped traffic, heroically forced the dog into his car and brought it to the studio. We now have a brown cocker spaniel that is terrified of all of us. Is this your dog? See pics and video @kleinallyshow on IG and YouTube. She took a shit in our parking garage. We also all got jabbed today by the guys at Evolve Anti-Aging, a place that specialized is Testosterone replacement therapy. We all got our blood drawn live on the air and the person with the highest T count will win the dollar equivalent of their level. 500ng = $500!! The owner joins us in-studio tomorrow to go over the results. Plus one of the most exciting Generation Wars of 2026, Second Hand Cindy receives an award, and Jake the Nerd is single-handedly saving Krispy Kreme. Buy up the stock while you can!!!

Is what I've been doing for years helpful for achieving autophagy?When you say low carb, do you mean low complex carb or low simple and processed carb?What daily multivitamin would you recommend for a male age 50 plus?Which supplement should I take for elevated triglycerides?

Integrative Healthcare Symposium highlightsWhat supplements can help combat the side effects of cancer therapy?Will my son's use of Zepbound affect his fertility?

Are men wimps or just immunologically inferior? Chris and Sophie review the evidence to decide if respiratory viruses really do hit men harder or if they are just looking for attention. Also Chris gushes about his favorite TV show, “All Creatures Great and Small.”    Become a supporter of our show today either on Patreon or through PayPal! Thank you! http://www.patreon.com/thebodyofevidence/ https://www.paypal.com/donate?hosted_button_id=9QZET78JZWCZE   Email us your questions at thebodyofevidence@gmail.com.   Editor:    Robyn Flynn Theme music: “Fall of the Ocean Queen“ by Joseph Hackl Rod of Asclepius designed by Kamil J. Przybos Chris' book, Does Coffee Cause Cancer?: https://ecwpress.com/products/does-coffee-cause-cancer   Obviously, Chris is not your doctor (probably). This podcast is not medical advice for you; it is what we call information. References: 1) Sophie's article: 2) BMJ review:  https://www.bmj.com/content/359/bmj.j5560 3) Man flu is not a thing post-hoc analysis: https://www.sciencedirect.com/science/article/pii/S0022399922003324#bbb0155

Are low energy, fading drive, and stubborn belly fat really “just aging,” or is something else going on?Many men over 50 assume their best years are behind them physically. Fatigue, muscle loss, and declining libido get written off as normal. But for some men, low testosterone is the real issue. The problem is not lack of effort. It is lack of clarity.In this conversation, Dr. Max Draper shares his brand-new book, Testosterone Decoded, and explains how to increase testosterone safely and responsibly, including when to increase testosterone naturally and when testosterone replacement therapy or TRT may be appropriate.Listeners will discover:The early signs of low testosterone most men ignoreWhat proper blood work should include before considering TRTThe difference between lifestyle fixes and medical therapyPress play to get clear, practical guidance so you can make informed decisions with confidence.Get Dr. Draper's book here.If you find this episode helpful, please subscribe and share it with friends and family.NEW FOR 2026: Click here to get my weekly Unstoppable After 50 Playbook

Male fertility is declining, and most men have no idea why.In this episode of The Dr. Gabrielle Lyon Show, Dr. Gabrielle Lyon sits down with Dr. Michael Eisenberg, Director of Male Reproductive Health at Stanford University and Chief Medical Advisor of SwimClub, to break down what truly determines sperm health and reproductive success.They discuss:How metformin, GLP-1 medications, testosterone therapy, and anabolic steroids affect male fertilityWhy sperm count is a powerful biomarker for long-term health and longevityThe role of sleep, muscle mass, exercise, diet, marijuana, and environmental toxins like microplasticsWhether platelet-rich plasma, or PRP, can help severe male infertilityDaily habits that quietly reduce a couple's chances of conceivingIf you care about fertility, hormones, metabolic health, or the future of men's health, this conversation is essential.Want ad-free episodes? Subscribe to Forever Strong Insider: https://foreverstrong.supercast.comThank you to our sponsors: BodyHealth - Get 20% off your first order with code LYON20 https://www.bodyhealthaffiliates.com/73L4QL3/7XDN2/Carol Bike - Visit https://carolbike.com/ and use code LYON for $100 off your CAROL BikeOneSkin - Get 15% off at https://www.oneskin.co/ with code DRLYONFind Dr. Michael Eisenberg at: Eisenberg Lab: https://med.stanford.edu/eisenberglab.htmlLinkedIn: https://www.linkedin.com/in/michael-eisenberg-9230a429X: https://x.com/DrMEisenbergFind Dr. Gabrielle Lyon at: Instagram:@drgabriellelyonTikTok: @drgabriellelyonFacebook: facebook.com/doctorgabriellelyonYouTube: youtube.com/@DrGabrielleLyonX (Twitter): x.com/drgabriellelyonApply to become a patient –

“The quality of your life is the quality of your relationships.” — Tony RobbinsToday, we welcome back Dr. John Gray, author of the global phenomenon Men Are from Mars, Women Are from Venus, the best-selling relationship books of all time.John has spent 40+ years helping people build stronger relationships by understanding the biological and emotional differences between men and women.His groundbreaking work has been translated into 45 languages and continues to shape how we think about love, intimacy, and partnership.In this episode, John dives deeper into modern relationships — from the impact of stress and hormones on attraction, to the biggest mistakes couples make, and what you can do right now to reignite connection, passion, and trust.We'll also go through:• Why understanding hormones is key to lasting attraction• The #1 reason couples fall into a rut — and how to fix it• How to fight less, reconnect faster, and deepen intimacy• The truth about modern masculinity and feminine power• And how to build a relationship that gets better with time

In this episode of SHE MD, Mary Alice Haney and Dr. Thaïs Aliabadi welcome back Dr. Kelly Casperson to discuss perimenopause, menopause, and hormone therapy with clarity and science instead of fear.Dr. Casperson explains why perimenopause is a clinical diagnosis, not simply a lab result, and why so many women are dismissed as “too young” or “too old” when their symptoms are real. She addresses the biggest myth about hormone replacement therapy and reframes the conversation around individualized, science-backed risk-benefit decisions.The discussion dives into testosterone for women, including its impact on libido, motivation, muscle mass, and mood, along with the risks of high-dose hormone pellets. They explore progesterone for sleep, the hysterectomy myth, and why vaginal estrogen is one of the safest and most effective treatments for dryness, painful sex, bladder urgency, and recurrent UTIs.The episode also tackles the midlife brain, brain fog, and how estrogen influences glucose metabolism. From restoring desire in long-term relationships to navigating alcohol, supplements, and exercise, this conversation reinforces one powerful truth: women are not broken. With the right knowledge and support, midlife can be a season of clarity, strength, and transformation.Subscribe to SHE MD Podcast for expert tips on PCOS, Endometriosis, fertility, and hormonal balance. Share with friends and visit SHE MD website and Ovii for research-backed resources, holistic health strategies, and expert guidance on women's health and well-being.Sponsors: Premier Protein: Find your favorite flavor at PremierProtein.com or at Amazon, Walmart, and other major retailers.Prolon: Ready for your own reset? For a limited time, Prolon is offering SHE MD listeners15% off site wide plus a $40 bonus gift when you subscribe to their 5-Day Program! Just visit ProlonLife.com/SHEMD to claim your 15% discount and your bonus gift.Mill: Try Mill risk-free for 90 days and get $75 off at mill.com/SHEMD and use code SHEMD at checkout.Peloton - Let yourself run, lift, sculpt, push, and go. Explore the new Peloton Cross Training Tread+ at onepeloton.com Talkiatry: Head to Talkiatry.com/shemd and complete the short assessment to get matched with an in‑network psychiatrist in just a few minutes.Warby Parker: Warby Parker gives you quality & better-looking prescription eyewear at a fraction of the going price. Our listeners get 15% + Free Shipping when they buy 2 or more pairs of prescription glasses at WarbyParker.com/SHEMD. What You'll Learn:What perimenopause actually is and why labs are not required for diagnosisThe biggest myth about hormone therapy and how fear shaped menopause careHow testosterone supports libido, motivation, and muscle strength in womenWhy vaginal estrogen is safe and essential for preventing dryness and UTIsWhat happens to the brain in midlife and why brain fog occursKey Timestamps:(01:30) Introduction and why Dr. Casperson wrote The Menopause Moment(04:10) The biggest myth about hormone therapy and why fear still shapes menopause care(09:25) Meet the hormones: testosterone, estrogen, and progesterone in midlife(11:50) Testosterone for women: libido, motivation, muscle, and dosing concerns(14:45) Hormone pellets explained: side effects, hair loss, and why removal is difficult(17:15) Progesterone for sleep and the hysterectomy myth clarified(24:25) Symptoms of too much estrogen(26:00) “Senile Vagina” - the “use it or lose it” myth(33:05) Vaginal atrophy, bladder symptoms, UTIs, and why vaginal estrogen matters(34:00) How to properly apply vaginal estrogen and why cream can be more effective(41:20) Great sex in midlife: lube and honest communication(50:30) Responsive vs spontaneous desire and bringing novelty back to long-term relationships(56:15) The midlife brain: estrogen, glucose metabolism, and brain fog(01:02:50) Alcohol, supplements, exercise, and non-hormonal tools for cognitive health(01:05:00) Final advice for women entering midlife and why you are not brokenKey Takeaways:Hormone therapy decisions should be individualized and based on science, not fearPerimenopause is common, real, and often underdiagnosedTestosterone plays a significant role in women's well-being beyond libidoVaginal estrogen is one of the safest and most effective preventive treatments in menopauseMidlife can be a powerful reset when women prioritize their health and mindsetGuest Bio:Dr. Kelly Casperson is a urologist, educator, and top international podcaster whose mission is empowering women to live their best love lives. In her podcast, You Are Not Broken, she combines science, humor, and candor to dismantle the myths women have learned about sex, intimacy, midlife, and hormones.Dr. Casperson earned her medical degree from the University of Minnesota and completed her surgical training and residency at the University of Colorado. She is a proud member of the American Urological Association, International Society for the Study of Women's Sexual Health, and the Society of Women in Urology.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Dr. Delaney sits down with acclaimed developmental psychologist David Yeager, Ph.D., to discuss his groundbreaking book, 10 to 25: The Science of Motivating Young People. Together, they delve into the transformative power of adopting a mentor mindset to simplify parenting — especially when tackling tech time challenges. Learn why combining high standards with high support is a game-changer, and uncover the key elements of "wise feedback" that make it so impactful, as shown across various studies. This episode offers science-backed communication techniques on topics like respectful versus disrespectful language, validation, cooperative problem-solving, and more. Parents will walk away with practical strategies to approach screen time struggles with confidence and clarity.   Featured Expert David Yeager, PhD   Books The Science of Motivating Young People, by David Yeager Belonging: The Science of Creating Connection and Bridging Divides, by Geoffrey L. Cohen   Research References Yeager, D. et al. Breaking the cycle of mistrust: Wise interventions to provide critical feedback across the racial divide. Journal of Experimental Psychology: General, 143(2), 804–824, 2014.  Dobson, K. et al. A Transparency Statement Improves Community-Police Interactions. Research Square (Research Square), 2022. Yeager, D. et al. A Transparency Statement Transforms Community-Police Interactions. Research Square (Research Square), 2022. Telzer, E. et al. Ventral striatum activation to prosocial rewards predicts longitudinal declines in adolescent risk taking. Developmental Cognitive Neuroscience, 3, 45–52, 2013.   Time Code 00:00 Introduction to the Screenagers Podcast 00:23 Meet David Yeager: Growth Mindset and Mentor Mindset 02:34 The Mentor's Dilemma: Balancing Criticism and Support 04:23 Wise Feedback: The Key to Motivating Youth 10:17 Transparency and Benevolent Intentions 12:45 Understanding Adolescent Motivation: Status and Respect 17:42 The Role of Testosterone in Adolescent Development 20:47 Respectful Communication: The Vegemite Experiment 24:15 Testosterone and Behavior 25:50 Parenting Challenges and Mentor Mindset 27:04 The Science of Nagging 29:25 Effective Communication with Teens 32:45 Collaborative Troubleshooting 34:41 Balancing Screen Time and Life Goals 36:53 The Enforcer vs. Mentor Mindset 41:30 Concluding Thoughts and Resources  

Send a textHow the body's internal circadian clocks regulate metabolism, energy balance, and health.TOPICS DISCUSSED:Master circadian clock in the brain: Light detection via retina entrains the suprachiasmatic nucleus, which coordinates body-wide rhythms; intrinsic period slightly deviates from 24 hours, allowing seasonal flexibility.Peripheral clocks in organs: Nearly all cells have autonomous clocks; liver and fat clocks rapidly adjust to feeding time, while brain clock aligns more tightly to light.Clock mutations and metabolism: Disrupting core clock genes (e.g., CLOCK, BMAL1) causes obesity, liver fat accumulation, and impaired insulin secretion without hyperinsulinemia.Timing of food intake: Eating the same high-fat calories during rest phase causes more weight gain than during active phase due to differences in energy dissipation.Modern disruptions (jet lag, shift work, blue light): Create desynchrony between brain and peripheral clocks, contributing to metabolic issues; late-night eating impairs glucose handling.Critical illness & feeding: Tube feeding at night (opposite natural cycle) induces rapid insulin resistance, highlighting mismatch costs.Hormone rhythms: Testosterone, glucocorticoids, and others peak at specific times; misalignment affects stress, reproduction, and metabolism.Weight loss drugs & maintenance: GLP-1 drugs reduce intake effectively, but regain involves neuroendocrine adaptations tied to brain clock pathways.ABOUT THE GUEST: Joseph Bass, MD, PhD is Chief of Endocrinology, Metabolism and Molecular Medicine at Northwestern University Feinberg School of Medicine, Director of the Center for Diabetes and Metabolism, and a leading researcher who pioneered the link between circadian clock genes and metabolic disorders including obesity and diabetes.RELATED EPISODE:M&M 237 | Circadian Biology: Genetics, Behavior, Metabolism, Light, Oxygen & Melatonin | Joseph TakahashiSupport the showHealth Products by M&M Partners: SporesMD: Premium mushrooms products (gourmet mushrooms, nootropics, research). Use code 'nickjikomes' for 20% off. Lumen device: Optimize your metabolism for weight loss or athletic performance. MINDMATTER gets you 15% off. AquaTru: Water filtration devices that remove microplastics, metals, bacteria, and more from your drinking water. Through link, $100 off AquaTru Carafe, Classic & Under Sink Units; $300 off Freestanding models. Seed Oil Scout: Find restaurants with seed oil-free options, scan food products to see what they're hiding, with this easy-to-use mobile app. KetoCitra—Ketone body BHB + electrolytes formulated for kidney health. Use code MIND20 for 20% off any subscription (cancel anytime) For all the ways you can support my efforts

When we talk about hormones and women's sexual health, the focus is almost always on estrogen. But testosterone also plays a key role in desire, arousal, and overall sexual well-being. Despite being labeled a “male hormone,” women produce (and need) it too. In this episode, we separate myth from fact about testosterone in women and why it remains one of the most overlooked topics in sexual medicine. I am joined once again by Dr. Maria Sophocles, a board-certified OB/GYN and Menopause Society Certified Practitioner. She is the CMO of EMBR Labs, a Boston-based wellness device company. Maria is also author of the new book, The Bedroom Gap, which is all about sex at midlife. Some of the specific topics we explore in this episode include: What testosterone does in women's bodies and sex lives How levels change across the lifespan When testosterone may help menopausal symptoms Potential risks and side effects Why there's still no FDA-approved testosterone treatment for women To learn more about Maria’s work, you can check out her website. Got a sex question? Send me a podcast voicemail to have it answered on a future episode at speakpipe.com/sexandpsychology. *** Thank you to our sponsors!  Soaking Wet from VB Health is the world’s first probiotic specifically designed for vaginal and vulva health and wellness. It’s a doctor formulated blend of prebiotics, probiotics, and vitamins specifically designed to restore balance and increase lubrication. Visit vb.health and use code JUSTIN for 10% off. The Kinsey Institute is where the world turns to understand sex and relationships. You can help continue its expert-led research by donating to the Kinsey Institute Research Fund. Learn more and make a donation here: https://give.myiu.org/centers-institutes/I380010749.html  *** Want to learn more about Sex and Psychology? Click here for previous articles or follow the blog on Facebook, Twitter, or Bluesky to receive updates. You can also follow Dr. Lehmiller on YouTube and Instagram. Listen and stream all episodes on Apple, Spotify, or Amazon. Subscribe to automatically receive new episodes and please rate and review the podcast! Credits: Precision Podcasting (Podcast editing) and Shutterstock/Florian (Music). Image created with Canva; photos used with permission of guest.

Is cholesterol bad? Is low cholesterol safe? In this video, we'll cover common cholesterol misinformation, how cholesterol was demonized, and the cholesterol truth you need to know now for better health.

In this episode, I sit down with neuroscientist Dr. Louisa Nicola to unpack what women actually need to know about Alzheimer's risk, cognitive decline, and long term brain protection. We break down APOE genetics, advanced blood biomarkers that can now detect amyloid and tau with remarkable accuracy, and why brain health is inseparable from metabolic health. Louisa explains how muscle acts as a metabolic sink for glucose, why resistance training and high intensity intervals stimulate BDNF, and how sleep drives the glymphatic system to clear amyloid from the brain. If you want practical tools to assess your personal risk, understand your labs, and build a proactive prevention plan decades before symptoms appear, this conversation is for you. → Leave Us A Voice Message!  Topics Discussed: → What does APOE4 mean for Alzheimer's risk? → Can exercise prevent cognitive decline? → Do blood tests detect early Alzheimer's? → How does perimenopause affect brain health? → Does hormone therapy reduce dementia risk? Sponsored By:  → Timeline | Support your cells and how you age with Mitopure® Gummies from Timeline. Visit https://timeline.com/KELLY and save up to 39% off your Mitopure® Gummies. → Be Well By Kelly Protein Powder & Essentials | Get $10 off your order with PODCAST10 at https://bewellbykelly.com. → Cozy Earth |  Head to https://cozyearth.com and use code BEWELL for up to 20% off. And if you get a post-purchase survey, make sure you tell them you heard about Cozy Earth right here at the Be Well by Kelly podcast.  → LMNT | Get a free 8-count Sample Pack of LMNT's most popular drink mix flavors with any purchase at https://drinklmnt.com/Kelly. Find your favorite LMNT flavor, or share with a friend. Timestamps:  → 00:00:00 - Introduction → 00:01:27 - Mission to end Alzheimer's  → 00:03:28 - Women's rate of Alzheimer's  → 00:04:11 - Alzheimer's overview  → 00:07:44 - Education level & health  → 00:09:57 - Anatomy  → 00:14:16 - Neuroplasticity & glucose  → 00:19:38 - Amyloid-beta → 00:26:41 - LDL Cholesterol → 00:28:36 - Preparing for menopause  → 00:31:30 - Blood testing recommendations  → 00:34:26 - Lifestyle interventions  → 00:39:05 - Nutrition & the MIND diet  → 00:42:19 - Zone 2 vs zone 5 training  → 00:44:36 - Lactic acid  → 00:47:58 - HRT is protective → 00:50:19 - When to test for HRT → 00:51:56 - Testosterone + brain health  → 00:53:40 - Cognitive reserve  → 00:57:12 - Hot flashes  → 00:58:13 - Quick fixes  → 01:00:01 - Brain surgery  → 01:05:38 - The brain code  Show Links: → Function | Own your health for $365 a year. That's a dollar a day. Learn more and join using my link. Visit https://www.functionhealth.com/bewellbykelly and use gift code BEWELL25 for a $25 credit toward your membership Further Listening: → How to Take Control of Your Health in a Toxic Food Landscape | Max Lugavere  Check Out Louisa:  → Instagram  → The Brain Code Check Out Kelly: → Instagram → Youtube → Facebook

(February 18, 2026) Citing fire risk, L.A. city may get more power to remove hillside homeless encampments. Venezuela’s oil industry is in ruins… reviving it won’t be easy. Dr. Jim Keany, Chief Medical Officer at Dignity Health St. Mary Medical Center in Long Beach, joins The Bill Handel Show for 'Medical News'! Dr. Keany talks with Bill about intermittent fasting, sex drive and testosterone, AI stethoscopes, and Norovirus at the Winter Olympics. See omnystudio.com/listener for privacy information.

Perimenopause and Menopause Myths Busted! Welcome back to the Menopause Mastery Podcast! In this eye-opening episode, Dr. Betty Murray and guest Kelly Resendez get real about the top myths and truths that surround perimenopause, menopause, and post-menopause—especially when it comes to hormone replacement therapy. From the difference between bioidentical and synthetic hormones to the controversies sparked by past research, they break down the complexities in simple, relatable terms. Dr. Betty Murray shares the latest science on what actually keeps women healthy as they age, including the impact of hormones on long-term health, bone density, brain function, and more. Plus, they tackle the confusion around lab ranges, hormone metabolism, and the power of having individualized care. Whether you're navigating these changes yourself or supporting someone who is, this episode will empower you with the knowledge, the facts, and the hope you need to take control of your hormonal health—without judgment or misinformation. Let's set the record straight and help you thrive during every stage of your menopause journey! Chapters: 00:00 "Bioidentical vs Synthetic Hormones" 03:23 Synthetic vs. Bioidentical Hormones 06:34 Menopause Hormone Therapy Controversy 11:13 "Hormones: The Body's Cleanup Crew" 13:15 Patient Story: Hormone Therapy Oversights 18:45 "Testosterone and Women's Health" 19:46 "Empowering Women Through Hormone Care" 23:47 "Menopause Mastery: Real Solutions"   Quick Takeaways: Start the HRT conversation early—within 10 years of menopause is optimal for the best long-term benefit. Bioidentical HRT is individualized: what works for your best friend isn't automatically right for you. Testing matters: Only using symptoms to judge your treatment might leave you unprotected; get those numbers checked! Don't let someone else's bad experience steer you away—your journey is unique, and doses can be tailored just for you. If you're ready to stop guessing and want a plan that's tailored to you, check out gethormonesnow.com. We're here to guide you through every step. Let's make this your most empowered chapter yet.  

Breast cancer screening is often treated as a given. Mammograms are framed as routine, early detection as unquestionably life-saving, and following guidelines as the responsible choice. But what if the full picture is more complicated?In this episode of hol+, Dr. Taz sits down with integrative oncologist and breast surgeon Dr. Jenn Simmons, author of The Smart Woman's Guide to Breast Cancer, to explore what breast cancer screening data actually shows, where common narratives may oversimplify reality, and how statistics can sometimes be misunderstood by both patients and providers.Together, they discuss the difference between screening and diagnostic imaging, why detecting more cancers does not always mean fewer deaths, and how concepts like overdiagnosis and lead-time bias shape our interpretation of outcomes. Dr. Jenn also explains how breast cancer behaves differently from many other cancers, why progression is not always linear, and what tumor markers like ER, PR, HER2, and triple-negative really indicate.The conversation expands beyond imaging into a whole-body view of breast health, touching on inflammation, immune function, metabolic health, toxic burden, stress, and lifestyle as factors that shape cancer risk and recovery. Rather than promoting fear or urgency, this episode focuses on helping listeners understand their bodies, ask better questions, and make informed decisions with clarity.This episode is for anyone who wants a deeper understanding of breast cancer screening, feels overwhelmed by conflicting guidance, or wants to approach breast health with more nuance and less panic.About Dr. Jenn SimmonsDr. Jenn Simmons is an integrative oncologist, breast surgeon, and founder of Real Health MD. She was Philadelphia's first fellowship-trained breast surgeon and spent nearly two decades leading one of the region's top breast programs before transitioning into integrative oncology.Drawing from her experience in conventional cancer care and her own health journey, Dr. Simmons now focuses on whole-body approaches to breast health, cancer prevention, and recovery, including metabolic health, inflammation, immune function, lifestyle medicine, and root-cause healing. She is the author of The Smart Woman's Guide to Breast Cancer, a patient-centered resource designed to help women better understand their diagnosis, ask informed questions, and navigate treatment decisions with clarity rather than fear.Order the BookThe Smart Woman's Guide to Breast Cancer Stay Connected:Connect further to Hol+ at https://holplus.co/- Don't forget to like, subscribe, and hit the notification bell to stay updated on future episodes of hol+.Follow Dr. Jenn SimmonsInstagram: https://www.instagram.com/drjennsimmonsYouTube: https://www.youtube.com/@dr.jennsimmonsWebsite: https://www.jennsimmonsmd.com/Follow Dr. Taz on Instagram: https://www.instagram.com/drtazmd/https://www.instagram.com/liveholplus/Subscribe to the audio podcast: https://holplus.transistor.fm/subscribeSubscribe to the video podcast: https://www.youtube.com/@DrTazMD/podcastsGet your copy of The Hormone Shift: Balance Your Body and Thrive Through Midlife and MenopauseHost & Production TeamHost: Dr. Taz; Produced by ClipGrowth.com (Producer: Pat Gostek)00:00 Swedish trial claim and overdiagnosis framing 00:52 Why this became a part two conversation 03:25 Reframing screening narratives and medical training gaps 04:39 Why Dr. Simmons questions mammograms as a screening tool 06:06 Origins of screening programs and “invitation to screen” bias 07:12 Relative risk vs absolute numbers example (4 vs 5 per 1,000) 08:49 Overdiagnosis explained with a vivid analogy 09:50 Autopsy-study claim and the “microscopic cancer” idea 12:11 Swedish trial claim revisited: more diagnoses, same deaths 13:38 Downstream harms: callbacks, biopsies, overtreatment 15:04 Lead-time bias and survival statistics explained 16:44 Dr. Simmons' view on the founder's regret narrative 18:16 Switzerland headline clarified and what actually changed 20:10 Cautionary stories and aggressive cancers discussion 22:07 Why breast cancer does not always progress linearly 24:21 Buckets: DCIS, invasive, inflammatory, receptor types 26:15 Clinical vs subclinical disease approach 28:25 Long-term tradeoffs and “forgotten woman” after treatment 32:15 What ER PR HER2 mean biologically and system incentives 35:33 Testosterone discussion and prevention claim presented 42:15 Hormones after breast cancer and the 4-year “reintroduction” idea 44:29 Triple negative: environment, toxicity, immune system focus 49:19 What to do next: pause, exceptions, whole-body workup 52:32 Prevention and breast health approach begins 53:24 At-home tears test explanation (as discussed) 56:24 Detox basics and why sweating is emphasized 59:34 Imaging preferences for screening and what to do if limited access

Dr. Lauren Colenso-Semple, PhD, is an expert in the science of strength and muscle building and nutrition. She explains the most effective resistance and cardiovascular training programs for women and if and how those programs should differ from those followed by men. She explains program design options, exercise selection, sets, repetition ranges, rest periods, if you need to train to failure and much more. We discuss the relevance of menstrual cycles, (peri)menopause, birth control, body frame differences, as well as best practices for nutrition, hormone replacement and supplementation. Throughout the episode Dr. Lauren Colenso-Semple dispels common myths about women's fitness and nutrition such as the impact of fasting, cortisol, weight vests and more. This episode provides a masterclass in the best science-supported fitness and nutrition programs for women and for men. Thank you to our sponsors AG1: https://drinkag1.com/huberman Joovv: https://joovv.com/huberman Eight Sleep: https://eightsleep.com/huberman Rorra: https://rorra.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Lauren Colenso-Semple (00:02:43) Muscle in Men vs Women; Testosterone; Individual Variation (00:08:07) Sponsors: Joovv & Eight Sleep (00:10:45) Testosterone & Women; Resistance Training; Young Girls (00:17:46) Tool: Beginner Resistance Training for Women; Frequency & Goals (00:20:58) Tools: Weekly Full-Body Workouts, Work Sets, Rest Intervals; Time Efficiency (00:28:43) Forced Reps, Drop Sets; Rate of Movement; Partial Reps (00:33:19) Tool: Repetition Ranges; Technique; Vary Rep Ranges? (00:39:37) Sponsor: AG1 (00:40:28) High Reps & Injury, Technique & Warm-Ups (00:44:25) Cardiovascular Exercise, Interference Effect?; Walking, High Intensity (00:52:43) Menstrual Cycle, Hormones & Training; Overcoming Internal Resistance (00:56:54) Training & Body Composition; Tool: Slow Progression; Menstrual Cycle (01:02:45) Sponsor: Rorra (01:03:59) Hormone Contraception & Adaptations; Perimenopause, Menopause (01:09:01) Age-Related Muscle Loss, Nervous System, Tool: Machines & Group Fitness (01:14:57) Menstrual Cycle & Physical Activity; Nutrition (01:17:50) Pilates, Genes, Tool: Resistance Training to Offset Age-Related Muscle Loss (01:26:25) Ectomorph, Mesomorph or Endomorph? (01:28:55) Sponsor: Function (01:30:42) Train Fasted?, Caffeine, Preworkout & Postworkout Nutrition (01:38:29) Protein, Resistance Training & Timing (01:40:12) Creatine Supplements, Gummies, Dose, Brain Health Benefits? (01:45:44) Individual Experience; Skepticism & Science, Menopause & Body Composition (01:54:52) Cortisol & Women, Stress & Diet, Cushing Syndrome (02:00:17) Overtraining?, Sleep Disruptions, Energy & Training Time (02:04:07) Menopause Symptoms & Hormone Therapy, Testosterone (02:09:22) Women Differences in Diet & Training?; Exercise Science Studies (02:16:19) Lauren's Training Schedule, Mobility Work (02:19:35) Hormone Therapy & Long-Term Outcomes; Deliberate Cold Exposure (02:23:06) Zone 2 Cardio; Weighted Vest; Balance Training; Ab Exercises; Recovery (02:29:26) Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

https://truedark.com/discount/DAVETUBEMost people believe testosterone declines simply because of age. That explanation is easy, familiar, and wrong. Testosterone is not primarily controlled by how hard you train, how clean you eat, or how stressed you feel during the day.It is controlled by what happens in your brain at night. This video explains how sleep architecture works, why deep sleep is the foundation of hormone production, and how common nighttime habits flatten testosterone signals at the source.It also walks through practical ways to restore proper sleep timing, protect deep sleep, and rebuild the hormonal rhythm the body depends on.Timestamps:00:00 - Why testosterone decline is not just about aging01:12 - When testosterone is actually made in the body01:37 - Deep sleep explained (slow-wave sleep / N3)02:14 - “Fake aging”: why you feel older than you are03:35 - Why 8 hours of sleep can still fail you05:39 - How to protect deep sleep09:45 - How light at night confuses your brain's clock12:11 - How to protect your eyes and sleep at night14:20 - What happens when sleep is finally fixedThank you to our sponsors! Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave.EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.Resources: • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In this Huberman Lab Essentials episode, I explore the psychology and biology of desire, love and attachment. I explain how childhood attachment styles can shape adult romantic relationships and how the brain and body systems influence emotional bonds. I also discuss supplements that may support a healthy libido and practical, science-based tools for understanding your relationship patterns and building stronger relationships. Read the episode show notes at hubermanlab.com. Thank you to our sponsors AG1: https://drinkag1.com/huberman Eight Sleep: https://eightsleep.com/huberman Function: https://functionhealth.com/huberman Timestamps (00:00:00) Desire, Love & Attachment (00:00:23) 4 Attachment Styles, Child & Parent (00:04:11) Attachment & Autonomic Arousal, Seesaw Analogy (00:07:26) Sponsor: Eight Sleep (00:08:44) Tool: Self-Awareness of Attachment Style, Autonomic State & Relationship (00:09:51) Brain & Neural Circuits for Desire, Love & Attachment (00:11:19) Empathy, Autonomic Matching (00:13:09) Positive Delusions, Relationship Breakdown & Failure (00:16:00) Sponsor: Function (00:17:39) Universality of Love, Autonomic Coordination (00:21:38) Self-Expansion & Relationships, Shaping Self-Perception (00:27:54) Sponsor: AG1 (00:28:44) Testosterone, Estrogen, Dopamine & Libido (00:31:52) Supplements to Increase Libido: Maca Root, Tongkat Ali (Longjack), Tribulus (00:38:55) Recap Disclaimer & Disclosures Learn more about your ad choices. Visit megaphone.fm/adchoices

What if the line between “medicine” and “forbidden” has nothing to do with safety and everything to do with permission? This episode gives you a clear framework for understanding peptides, research chemicals, and performance enhancement so you can think for yourself instead of outsourcing your biology Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dylan Gemelli for a candid, unfiltered conversation about the underground world of biohacking, research chemicals, and human performance. Dylan is a long-time biohacker, educator, and researcher who came out of the bodybuilding world and spent more than a decade studying peptides, SARMs, nootropics, and gray-area compounds. He brings first-hand experience, deep research literacy, and a rare ability to explain what these compounds actually do, where the risks are, and why most doctors will never talk about them. Together, they unpack what “research chemicals” really means, why peptides technically fall into that category, and how legality often has little to do with biological reality. They explore compounds like MK-677, S4, and other SARMs, how they interact with growth hormone, muscle, strength, and recovery, and why some of these tools can be more powerful than peptides when used with intention and restraint. Dave also shares his own experiences rebuilding his health using underground tools, why he refuses to ask for permission to take care of his body, and how performance enhancement fits into longevity, metabolism, and real-world function. You'll Learn: • What research chemicals actually are and why peptides fall into that category • How compounds like MK-677 stimulate growth hormone and affect muscle and recovery • Why SARMs differ from steroids and where the real risks come from • The difference between tobacco and nicotine and why low-dose nicotine can support brain optimization • How performance enhancement fits into longevity, metabolism, and functional medicine thinking • Why strength and neurological drive matter more than size alone • How to think clearly about supplements, nootropics, and biohacking tools without fear or hype • Why taking responsibility for your biology is not cheating Dave Asprey is a four time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living. Thank you to our sponsors! • Antarctica Trip | Join me in Antarctica from March 8–17, 2026. Visit https://www.insiderexpeditions.com/future and use code DAVE for $1,000 off. • AirDoctor | Go to https://airdoctorpro.com/daveasprey and save up to $300 on Air Purifiers. • STEMREGEN | Go to https://stemregen.co/dave30 and use code DAVE30 for 30% off your next order. • Our Place | Visit https://fromourplace.com/DAVE and use code DAVE for 10% off sitewide. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: biohacking research chemicals, peptide biohacking podcast, underground peptides, SARMs explained, MK-677 growth hormone, performance enhancing drugs science, human performance biohacking, longevity biohacking podcast, neuroplasticity optimization, brain optimization nootropics, mitochondrial optimization biohacking, metabolism and hormones, testosterone optimization science, nicotine brain benefits, modafinil cognitive performance, supplements biohacking debate, functional medicine biohacking, muscle vs strength science, anti-aging performance strategies, Dave Asprey biohacking, Dylan Gemelli biohacking, The Human Upgrade podcast, Smarter Not Harder biohacking Resources: • Learn More About Dylan's Work And Content At: https://dylangemelli.com/ • Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/ • Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com Timestamps: 0:00 - Introduction 1:28 - SARMs & Research Chemicals 7:43 - 29 Pounds of Muscle in 6 Weeks 10:20 - MK-677 & Growth Hormone 16:41 - Vegan Diet Disaster 18:30 - From Bodybuilding to Biohacking 21:31 - Diet Transformation & Metabolism 29:14 - Reversing Heart Plaque 33:50 - Exercise, Cardio & Longevity 44:16 - Testosterone, TRT & Kyzatrex 50:06 - Healthcare Freedom 53:23 - Medical Freedom See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Full Show Notes: bengreenfieldlife.com/lnkyal/ In this episode, you'll get to discover the fascinating realm of revolutionary peptides with two-time guest, Kyal Van Der Leest — a distinguished naturopath, nutritionist, supplement formulator, and the founder of LVLUP Health (use code BEN10 to save 10%). Discover how these powerful compounds can rapidly repair tissues, elevate your energy by boosting NAD levels, sharpen your mind, and even naturally enhance sexual health, offering alternatives to medications like Viagra. Kyal Van Der Leest is the founder, formulator, and face of LVLUP Health, an Australian-based supplement company. Under his guidance, LVLUP Health (use code BEN10 to save 10%) has created a diverse range of cutting-edge supplements utilizing incredibly powerful ingredients that you may not have heard of before. His formulations aim to simplify complex health protocols, reducing the need for multiple products by offering all-in-one solutions that make supplementation easy and effective. Episode Sponsors: Apollo: Apollo is a safe and non-invasive wearable that actively improves your sleep. Head over to apolloneuro.com/bengreenfield and use code BENGREENFIELD for $90 off. Just Thrive: Just Thrive Probiotic is the only probiotic clinically proven to arrive 100% alive in your gut, wrestling in less bloat, better energy, and even clear skin. Digestive Bitters packs 12 science-backed herbs in one tasteless capsule that jumpstarts your digestion and supports GLP-1 production so cravings don’t control you. Visit justthrivehealth.com/BENand save 20% with promo code BEN. See the difference for yourself or get a full product refund, no questions asked. Sunlighten: Sunlighten's patented infrared sauna technology delivers the highest quality near, mid, and far infrared wavelengths to reduce inflammation, boost mitochondrial function, enhance detox pathways, and optimize recovery—backed by 25+ years of clinically proven, non-toxic innovation. Save up to $1,400 at get.sunlighten.com/ben with code BEN. Formula IQ: Recuperate IQ by Formula IQ is a comprehensive copper supplement designed to support mitochondrial energy, iron balance, and metabolic health by pairing bioavailable copper with essential cofactors your body needs for proper utilization, which is especially crucial if you've been under chronic stress or supplementing with high-dose zinc. Try it at formulaiq.com and use code BEN for 10% off. LeelaQ: Not only do LeelaQ’s products neutralize EMFs, increase ATP production, optimize HRV, and improve blood flow, but they've been third-party proven to do so in placebo-controlled double-blind studies. Visit leelaq.com and use code BEN10 for 10% off. See omnystudio.com/listener for privacy information.