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Mais sete agentes da PSP foram detidos, na sequência da investigação a crimes de tortura grave, violação, agressões e abuso de poder na Esquadra do Rato, em Lisboa. A este casos somam-se outros envolvendo agentes da PSP ou militares da GNR em grupos da extrema-direita violenta, actos racistas, participação em redes de tráfico humano. As direções destas duas forças de segurança dizem-se intransigentes perante os agentes da lei que não a cumprirem. Conversamos com Hugo Franco, o jornalista do Expresso que acompanha as questões de segurança, para tentar perceber o que se passa com a nossa polícia.See omnystudio.com/listener for privacy information.
durée : 00:03:25 - Guerre au Moyen-Orient : déjà des tensions sur le GNR - Depuis le début des frappes en Iran, le cours du GNR, le gazole non routier, a flambé de 25%. Les agriculteurs veulent se faire livrer au plus tôt, avant que le prix augmente encore et une éventuelle pénurie. Les fournisseurs sont surchargés d'appels et ont du mal à suivre. Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.
Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.
On this week's trip through the Mind of the Meanie, The Blue Meanie and Adam Barnard are joined by longtime Guns N' Roses tour manager and author of the graphic novel "Consensual Violence", Del James! Del talks about the novel, the AOL chat rooms he and Meanie belonged to, his love of wrestling, and an Ask Meanie with a bunch of GNR questions!Mind of the Meanie is an official Brand Partner of WWE Shop! Click this link here to shop WWE Shop and support your favorite WWE Superstar today: https://wwe-shop.sjv.io/eK26drGet 25% OFF your entire order using promo code MEANIE at GreenRoads.com - Own The Day with Green Roads CBD and Wellness Products!For more information and exclusive updates, follow Mind of the Meanie on Social Media.Website | Facebook | Twitter | InstagramBECOME AN OFFICIAL POD SQUAD MEMBER: www.Patreon.com/mindofthemeanie About The Blue Meanie:Since 1994, Brian Heffron, known to wrestling fans as "The Blue Meanie", has been one of the most fun loving and mischievous characters in wrestling. He's been in ECW, WWE, various independent wrestling promotions and several independent films. He is perhaps best known for his comedy and wrestling parodies with the bWo, KISS, Col. DeMeanie, Sir Meanie, The Fabulous Ones and BlueDust. Now, he meaniesaults into the world of streaming audio, sharing his experiences in and out of the ring as well as his views on the world of professional wrestling and anything else he is passionate about.About Adam Barnard:Adam Barnard is a photographer, podcaster, and an award winning writer from Downingtown, PA. Since 2019, he has hosted Foundation Radio, a weekly podcast series with new episodes every Tuesday, focusing on in depth conversations and interviews. Since 2025, Adam has been a writer, contributor, and interviewer for TheSportster for interviews and live results coverage. Adam brings his unique perspective and incredibly dry sense of humor to Mind of the Meanie each week.Hosts/Executive Producers: The Blue Meanie and Adam BarnardEngineer: Carl PannellExecutive Voice: Sam KreppsIntro music: Swamp CandlesOutro music: ChikaraMusical Accompaniment: EnrichmentA Butts Carlton Media Production. Butts Carlton, Proprietor.Become a supporter of this podcast: https://www.spreaker.com/podcast/mind-of-the-meanie--6219755/support.
Dans ce 18ème épisode, Godefroy Laurendeau qui poursuit sa réflexion sur notre rapport collectif à l'énergie et sur la transition énergétique qui au Québec (comme ailleurs dans le monde) a de l'eau dans le gaz (naturel récupérable). Et en édito, Fred revient sur le beau portrait de Louis Sarkozy que nous a offert la Presse et sur le bothsidisme entendu à la radio publique sur la possible fermeture de la fonderie Horne.
The Grammys put on a tribute to Ozzy with Slash, Duff from GnR, Chad from The Chilli Peppers & Post Malone.. it showed how great music still stands up & don't need gimmicks..The artists at the Grammys think they need to be outrageous but if you are try to be no is.. it's all cookie cutter nonsense..
O Tenente Francisco Rodrigues da GNR de Leiria explica o que esteve por trás da intoxicação do idoso por monóxido de carbono e deixa recomendação de segurança à população.See omnystudio.com/listener for privacy information.
Derek Shulman joins Eddie Trunk to discuss his new memoir 'Giant Steps: My Improbable Journey From Stage Lights to Executive Heights.' The conversation explores Shulman's unique career path from performing with progressive rock band Gentle Giant to becoming a powerful music executive who signed and developed some of rock's biggest acts. Shulman shares fascinating behind-the-scenes stories about working with Bon Jovi, Pantera, AC/DC, Kingdom Come, and Dan Reed Network. He reveals how his experience as a musician gave him a unique perspective when working with artists and discusses the tension between artistic passion and business demands in the music industry. After that, Dizzy Reed joins Eddie to discuss his latest solo album 'Rock 'N' Roll Chose Me', his second release following 2018's 'Rock 'N Roll Ain't Easy'. Reed shares insights into his songwriting process, musical influences including Deep Purple's Jon Lord, and collaborations with various musicians on the record. He reflects on his journey from playing keyboards at age 10 to joining Guns N' Roses, recent GNR tours across South America, and memorable performances to massive crowds. Catch Eddie Trunk every M-F from 3:00-5:00pm ET on Trunk Nation on SiriusXM Faction Talk Channel 103.And don't forget to follow Eddie on X and Instagram!Follow the link to get your free 3-month trial of SiriusXM: http://siriusxm.com/eddietrunk Find all episodes of Trunk Nation: https://siriusxm.com/trunknation Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Send us a textSocialsHosts: Peter Cabral: www.instagram.com/brisbane_north_photography/Andrew Parsons (he is not on social media)Instagram: www.instagram.com/3_chords_and_the_truth/Email: justhitplay7300@gmail.comwww.youtube.com/@justhitplaypodcastPodcast theme music by Paul J Rogers. Find him here:Spotify: https://open.spotify.com/artist/78Xwc4m4KtH2BPDLFDOQVd?si=gmLeRYAtQc2MK-DXPDZ6QwWebsite: https://pauljrogers.com/Instagram: https://www.instagram.com/pauljrogersmusic/ TikTok: https://www.tiktok.com/@pauljrogersmusic?_t=8qX73fxwaQhwww.instagram.com/justhitplaypodcast/
O ‘Doa a Quem Doer' desta semana revela o que as vítimas de Sérgio Ribeiro, o militar da GNR que burlou mais de 30 idosos, disseram sobre o criminoso. A mãe e o pai do militar, também envolvidos nas burlas, não aceitaram falar com a equipa do programa da CMTV.
Let Us Know What You Think of the Show!Date: January 7, 2026Name of Podcast: Backstage Pass RadioS10: E1: Austin Ingerman (Gunshine) - Gunshine From Sunshine StateSHOW SUMMARY:Big riffs, big hooks, zero apologies. That's the energy we chase with guitarist and songwriter Austin Ingerman of Gunshine, a Florida-born player who balances swagger with sharp songcraft. From Daytona beginnings to LA's Musicians Institute and arena tours as a hired gun, Austin shares how those miles shaped a band built for choruses you can shout and guitars that actually feel dangerous again. We talk origin stories the honest way: how a pandemic pause pushed Austin home, how early tracks came together before a singer was even in the room, and why the search for a voice with an X factor took years. When Jordan walked in from a dueling-piano bar, the chemistry clicked fast. The result is Gunshine's “swampy” identity—Southern edge, modern punch—rooted in influences like Boston, Def Leppard, AC/DC, and a touch of early GNR. The name Gunshine nods to Florida's nickname and the band's sunburned grit, not a retro costume. Songwriting sits at the center. Austin often starts with melodies and riffs captured on voice memos, while Jordan brings a Nashville-honed lyric lens and the number system to keep structures tidy. We break down “Bayou,” which began as Jordan's country-leaning sketch and morphed into a layered modern rocker with a ramping chorus. The home-studio pipeline is real: tracks built in Austin's space, files shipped to Chris Collier for mix and master, and a sound that still hits like a room full of amps. Theory helps in the background—tension, resolution, the occasional Mixolydian wink—but the rule is feel first. Grand Rising, a 13-song album, arrives with more colors: piano textures, heavier corners, and a stealth seven-string thickening the choruses without stealing the spotlight. We dig into touring momentum after a successful run through venues like the Whisky and Sturgis, plus the realities of booking while transitioning agencies. Austin's parting wisdom is pure working-musician truth: pick one job a day, finish it well, and let the songs lead everything else. If you crave straight-ahead rock with big melodies and no filler, hit play, follow Gunshine on socials, and watch for the first single on January 23. Enjoy the conversation, then subscribe, share, and leave a quick review so more rock fans can find the show.Sponsor Link:WWW.ECOTRIC.COMWWW.SIGNAD.COMWWW.RUNWAYAUDIO.COMBackstage Pass Radio Social Media Handles:Facebook - @backstagepassradiopodcast @randyhulseymusicInstagram - @Backstagepassradio @randyhulseymusicTwitter - @backstagepassPC @rhulseymusicWebsite - backstagepassradio.com and randyhulsey.comArtist(s) Web Pagewww.gunshineband.comCall to actionWe ask our listeners to like, share, and subscribe to the show and the artist's social media pages. This enables us to continue pushing great content to the consumer. Thank you for being a part of Backstage Pass Radio Your Host,Randy Hulsey
Temos o plano perfeito para a vossa noite de hoje: ver o concerto de 45 anos de carreira dos GNR na RTP1. São clássicos atrás de clássicos e brincadeiras do Rui Reininho ao vivo no Coliseu do Porto.
A história de muitas mulheres brasileiras que deixam o país em busca de segurança, estabilidade e uma vida melhor no exterior nem sempre encontra o final feliz que elas imaginavam. Para algumas, a violência atravessa oceanos. É nesse cenário complexo e muitas vezes invisível que atua a advogada Luana Ferreira, líder do Comitê de Direito das Mulheres do Grupo Mulheres do Brasil, em Lisboa. Lizzier Nassar, correspondente da RFI em Lisboa A violência viaja silenciosa, escondida dentro de malas, memórias, fragilidades e dependências. Em outras vezes, ela surge justamente no estrangeiro, onde a solidão da imigração, a falta de rede de apoio e o desconhecimento do sistema local criam o ambiente perfeito para que o ciclo se repita — ou se intensifique. A advogada brasileira Luana Ferreira, líder do Comitê de Direito das Mulheres do Grupo Mulheres do Brasil em Lisboa, conhece bem essas armadilhas. Ela se tornou, na prática, aquilo que tantas mulheres procuram desesperadamente quando decidem romper o silêncio: uma ponte. Uma mão estendida. Um lugar seguro onde é possível contar o que não se consegue nem admitir para si mesma. “Desde muito pequena eu vi e ouvia histórias de violência. Situações bem complicadas. Isso me tocou desde muito nova”, ela conta. O que poderia ter sido apenas uma lembrança dolorosa transformou-se em vocação. Hoje, ela trabalha diariamente para acolher mulheres que vivem aquilo que tantas outras, por gerações, foram ensinadas a suportar. O Comitê de Direito das Mulheres, que ela lidera, é dedicado à promoção e defesa dos direitos das mulheres, com especial atenção ao combate à violência doméstica — e com um objetivo central que vai além da assistência: sensibilizar a sociedade. “É importante trazer para as pautas sociais e para a sociedade que a violência doméstica é um problema de todos”, afirma. Os números comprovam que o problema é mais amplo do que a maioria imagina. Segundo dados do Ministério das Relações Exteriores, 1.631 casos de violência doméstica e de gênero contra brasileiras foram registrados em embaixadas e consulados em 2024 — um aumento de 4,8% em relação ao ano anterior. Os Estados Unidos lideram as notificações (397 casos), seguidos da Bolívia (258), Itália (153), Portugal (144) e Reino Unido (102). Cada número desses representa uma história que atravessou fronteiras carregando medo, insegurança e, muitas vezes, silêncio. Em Portugal, onde a advogada atua, a violência doméstica continua sendo o crime mais reportado. Só entre janeiro e agosto deste ano, a APAV — Associação Portuguesa de Apoio à Vítima — apoiou 14.008 mulheres. As situações de vitimação ocorreram em 89,9% dos municípios do país, com maior incidência nos distritos de Lisboa, Faro, Braga e Porto. Até setembro, 18 pessoas foram assassinadas em contexto de violência doméstica — 16 eram mulheres. E, segundo a PSP e a GNR, foram registradas 25.327 ocorrências nos primeiros nove meses do ano de 2025, o maior número dos últimos sete anos. Relutância em se reconhecer como vítima Esses dados ajudam a contextualizar uma realidade que, aos olhos da advogada, aparece diariamente em forma de relatos fragmentados, mensagens rápidas, áudios enviados com cuidado para que ninguém ouça, e pedidos de ajuda que começam hesitantes: “Não sei se isso é normal.” Muitas vezes, ela é a primeira pessoa a quem a mulher se direciona quando finalmente decide falar. “A mulher vive com medo: no lar, na sociedade, no dia a dia… Ela não sabe o que pode vir a acontecer se cruzar com o agressor ou se ele tiver acesso à vida que ela está construindo agora”, explica. Para ela, a violência doméstica não termina quando a relação termina. “É um crime que, muitas vezes, rouba a paz para sempre.” Entre os casos que chegam ao comitê, há agressões físicas e psicológicas, mas também formas de violência que muitas mulheres só descobrem quando já estão presas a elas. Uma das mais comuns entre brasileiras em Portugal é a violência administrativa. “O agressor retém, esconde ou inutiliza documentos da vítima. Já tivemos casos de passaportes rasgados, queimados, inutilizados — da mulher e das crianças”, relata. Impedida de viajar, de trabalhar ou de se movimentar, a vítima perde autonomia e fica ainda mais vulnerável. Escuta entre imigrantes Nesse contexto, a presença do comitê funciona como um abraço possível. A equipe escuta, orienta, encaminha e apoia. A rede inclui psicólogas, advogadas, associações especializadas e serviços públicos. E tudo começa com algo simples, mas fundamental: acreditar na vítima. “Quando são brasileiras — e elas são a maioria que nos procura — torna-se mais confortável encontrar outra imigrante do outro lado. É alguém que entende o medo, o idioma, a saudade, a culpa e a solidão.” Mas, apesar do apoio, o caminho institucional no país ainda apresenta lacunas importantes. Portugal não possui uma delegacia da mulher, como no Brasil. Não existe uma lei equivalente à Maria da Penha, que foi um divisor de águas no enfrentamento à violência doméstica no Brasil. O que há, em Lisboa, é o Espaço Júlia, na freguesia de Santo Antônio, que funciona como um atendimento especializado a vítimas — mas ainda insuficiente diante da dimensão do problema. “Falta muita coisa. É muito triste ver que ainda há quem finja que não é com ele. Precisamos de educação, conscientização e mudança cultural”, afirma. Manual de prevenção Nos últimos anos, algumas iniciativas importantes surgiram. O Consulado-Geral do Brasil em Lisboa, em parceria com o Instituto Nós Por Elas, lançou o Manual de Prevenção da Violência contra Mulheres Brasileiras no Exterior, elaborado pelo Ministério das Mulheres e pelo Ministério das Relações Exteriores. O consulado também formalizou sua adesão à campanha Sinal Vermelho Contra a Violência Doméstica, que orienta vítimas a desenharem um “X” na mão ou em um pedaço de papel para pedir ajuda de forma silenciosa e segura. Pequenos gestos que podem salvar vidas. Mas, para a advogada, a mudança real depende de algo maior: transformação cultural. “Não adianta tratar apenas a consequência. Precisamos mexer na raiz”, diz. E a raiz, segundo ela, começa pela frase que repete sempre: “Uma mulher agredida é todas nós agredidas.” Onde pedir ajuda Esta reportagem também é escrita para quem lê em silêncio. Para quem está tentando decidir se aquilo que vive é violência. Para quem tenta justificar o injustificável. Para quem acha que merece o que recebe. Para quem teme pedir ajuda. Para quem saiu do Brasil acreditando que finalmente teria paz — e encontrou medo. Se esse for o seu caso, saiba que você não está sozinha. Há uma rede inteira pronta para caminhar com você. Há mulheres — como a advogada Luana Ferreira — que dedicam suas vidas para acolher, orientar e proteger. Há profissionais, instituições, organizações e serviços que podem te ajudar a romper um ciclo que nunca deveria ter começado. Por mais difícil que pareça, existe um futuro possível. Pedir ajuda não é fraqueza — é coragem. E coragem é algo que toda mulher carrega dentro de si, mesmo quando acha que não.
A história de muitas mulheres brasileiras que deixam o país em busca de segurança, estabilidade e uma vida melhor no exterior nem sempre encontra o final feliz que elas imaginavam. Para algumas, a violência atravessa oceanos. É nesse cenário complexo e muitas vezes invisível que atua a advogada Luana Ferreira, líder do Comitê de Direito das Mulheres do Grupo Mulheres do Brasil, em Lisboa. Lizzier Nassar, correspondente da RFI em Lisboa A violência viaja silenciosa, escondida dentro de malas, memórias, fragilidades e dependências. Em outras vezes, ela surge justamente no estrangeiro, onde a solidão da imigração, a falta de rede de apoio e o desconhecimento do sistema local criam o ambiente perfeito para que o ciclo se repita — ou se intensifique. A advogada brasileira Luana Ferreira, líder do Comitê de Direito das Mulheres do Grupo Mulheres do Brasil em Lisboa, conhece bem essas armadilhas. Ela se tornou, na prática, aquilo que tantas mulheres procuram desesperadamente quando decidem romper o silêncio: uma ponte. Uma mão estendida. Um lugar seguro onde é possível contar o que não se consegue nem admitir para si mesma. “Desde muito pequena eu vi e ouvia histórias de violência. Situações bem complicadas. Isso me tocou desde muito nova”, ela conta. O que poderia ter sido apenas uma lembrança dolorosa transformou-se em vocação. Hoje, ela trabalha diariamente para acolher mulheres que vivem aquilo que tantas outras, por gerações, foram ensinadas a suportar. O Comitê de Direito das Mulheres, que ela lidera, é dedicado à promoção e defesa dos direitos das mulheres, com especial atenção ao combate à violência doméstica — e com um objetivo central que vai além da assistência: sensibilizar a sociedade. “É importante trazer para as pautas sociais e para a sociedade que a violência doméstica é um problema de todos”, afirma. Os números comprovam que o problema é mais amplo do que a maioria imagina. Segundo dados do Ministério das Relações Exteriores, 1.631 casos de violência doméstica e de gênero contra brasileiras foram registrados em embaixadas e consulados em 2024 — um aumento de 4,8% em relação ao ano anterior. Os Estados Unidos lideram as notificações (397 casos), seguidos da Bolívia (258), Itália (153), Portugal (144) e Reino Unido (102). Cada número desses representa uma história que atravessou fronteiras carregando medo, insegurança e, muitas vezes, silêncio. Em Portugal, onde a advogada atua, a violência doméstica continua sendo o crime mais reportado. Só entre janeiro e agosto deste ano, a APAV — Associação Portuguesa de Apoio à Vítima — apoiou 14.008 mulheres. As situações de vitimação ocorreram em 89,9% dos municípios do país, com maior incidência nos distritos de Lisboa, Faro, Braga e Porto. Até setembro, 18 pessoas foram assassinadas em contexto de violência doméstica — 16 eram mulheres. E, segundo a PSP e a GNR, foram registradas 25.327 ocorrências nos primeiros nove meses do ano de 2025, o maior número dos últimos sete anos. Relutância em se reconhecer como vítima Esses dados ajudam a contextualizar uma realidade que, aos olhos da advogada, aparece diariamente em forma de relatos fragmentados, mensagens rápidas, áudios enviados com cuidado para que ninguém ouça, e pedidos de ajuda que começam hesitantes: “Não sei se isso é normal.” Muitas vezes, ela é a primeira pessoa a quem a mulher se direciona quando finalmente decide falar. “A mulher vive com medo: no lar, na sociedade, no dia a dia… Ela não sabe o que pode vir a acontecer se cruzar com o agressor ou se ele tiver acesso à vida que ela está construindo agora”, explica. Para ela, a violência doméstica não termina quando a relação termina. “É um crime que, muitas vezes, rouba a paz para sempre.” Entre os casos que chegam ao comitê, há agressões físicas e psicológicas, mas também formas de violência que muitas mulheres só descobrem quando já estão presas a elas. Uma das mais comuns entre brasileiras em Portugal é a violência administrativa. “O agressor retém, esconde ou inutiliza documentos da vítima. Já tivemos casos de passaportes rasgados, queimados, inutilizados — da mulher e das crianças”, relata. Impedida de viajar, de trabalhar ou de se movimentar, a vítima perde autonomia e fica ainda mais vulnerável. Escuta entre imigrantes Nesse contexto, a presença do comitê funciona como um abraço possível. A equipe escuta, orienta, encaminha e apoia. A rede inclui psicólogas, advogadas, associações especializadas e serviços públicos. E tudo começa com algo simples, mas fundamental: acreditar na vítima. “Quando são brasileiras — e elas são a maioria que nos procura — torna-se mais confortável encontrar outra imigrante do outro lado. É alguém que entende o medo, o idioma, a saudade, a culpa e a solidão.” Mas, apesar do apoio, o caminho institucional no país ainda apresenta lacunas importantes. Portugal não possui uma delegacia da mulher, como no Brasil. Não existe uma lei equivalente à Maria da Penha, que foi um divisor de águas no enfrentamento à violência doméstica no Brasil. O que há, em Lisboa, é o Espaço Júlia, na freguesia de Santo Antônio, que funciona como um atendimento especializado a vítimas — mas ainda insuficiente diante da dimensão do problema. “Falta muita coisa. É muito triste ver que ainda há quem finja que não é com ele. Precisamos de educação, conscientização e mudança cultural”, afirma. Manual de prevenção Nos últimos anos, algumas iniciativas importantes surgiram. O Consulado-Geral do Brasil em Lisboa, em parceria com o Instituto Nós Por Elas, lançou o Manual de Prevenção da Violência contra Mulheres Brasileiras no Exterior, elaborado pelo Ministério das Mulheres e pelo Ministério das Relações Exteriores. O consulado também formalizou sua adesão à campanha Sinal Vermelho Contra a Violência Doméstica, que orienta vítimas a desenharem um “X” na mão ou em um pedaço de papel para pedir ajuda de forma silenciosa e segura. Pequenos gestos que podem salvar vidas. Mas, para a advogada, a mudança real depende de algo maior: transformação cultural. “Não adianta tratar apenas a consequência. Precisamos mexer na raiz”, diz. E a raiz, segundo ela, começa pela frase que repete sempre: “Uma mulher agredida é todas nós agredidas.” Onde pedir ajuda Esta reportagem também é escrita para quem lê em silêncio. Para quem está tentando decidir se aquilo que vive é violência. Para quem tenta justificar o injustificável. Para quem acha que merece o que recebe. Para quem teme pedir ajuda. Para quem saiu do Brasil acreditando que finalmente teria paz — e encontrou medo. Se esse for o seu caso, saiba que você não está sozinha. Há uma rede inteira pronta para caminhar com você. Há mulheres — como a advogada Luana Ferreira — que dedicam suas vidas para acolher, orientar e proteger. Há profissionais, instituições, organizações e serviços que podem te ajudar a romper um ciclo que nunca deveria ter começado. Por mais difícil que pareça, existe um futuro possível. Pedir ajuda não é fraqueza — é coragem. E coragem é algo que toda mulher carrega dentro de si, mesmo quando acha que não.
A situação arrasta-se há vários meses e agravou-se no período de Natal e Ano Novo. O governo anunciou, entretanto, a suspensão do novo sistema europeu de controle de fronteiras e mandou chamar, com carácter imediato, os militares da GNR. A ASPP acusa o toque, mas garante que não tem nenhuma responsabilidade pelos tempos de espera verificados. Para olhar para este problema que afecta a imagem do país, a vida de quem nos procura e as finanças das companhias de aviação, conversamos neste episódio com Paulo Geisler, presidente da RENA - Associação das Companhias Aéreas em Portugal.See omnystudio.com/listener for privacy information.
Paulo Santos, Presidente Associação Sindical de Profissionais da Polícia, acusa o Governo de propor "uma mentira". Denuncia que não há elementos da GNR disponíveis para assegurar este reforço. See omnystudio.com/listener for privacy information.
JN: Viúva e filhos de militar da GNR morto no Guadiana já receberam indemnização de 217,5 mil euros. El País destaca libertação de 71 presos políticos na Venezuela, a maior dos últimos meses. See omnystudio.com/listener for privacy information.
Matt Nathanson returns!Matt returns and we talk about U2 AGAIN!?! Heck Yeah! And, yes, we've already done an episode about "The Unforgettable Fire" but when Matt Nathanson says he wants to do an episode about the album, you let him.Plenty of other discussion including the Tampa Pig Jig and Megan Moroney, Live Aid, GNR, R.E.M.'s "Green," The Black Crowes, listening to the same song over and over, Def Leppard, MLK, the influence of Eno and Lanois, and much more. Check out Matt Nathanson at: https://mattnathanson.com/Check out other episodes at RecordsRevisitedPodcast.com, Apple Podcasts, Castbox, iHeartMedia, Google Podcasts and Spotify. Additional content is found at: Facebook.com/recordsrevisitedpodcast or twitter @podcastrecords or IG at instagram.com/recordsrevisitedpodcast/ or join our Patreon at patreon.com/RecordsRevisitedPodcast
We sally forth with more @QueensrycheOfficial albums - taking on the follow-up to "Operation: Mindcrime" with "Empire!" Did they make their best record? Did they influence @metallica to make the "Black Album?" Watch and see! We make references to Hockey Fights, @recordstoreday Black Friday, South Park, Nik tries to invoke his "legal team" - Human Centipede, Nik's knife injuries, Faith No MoreCheck out our last series on the Layne Staley years of Alice in Chains: • Alice In Chains
Bakko has some apologies. LC has some positivity. Jack White performs... LIVE! Daughtry disses Draiman. Oasis somehow trolls Machine Head. Nuthin' But A Good time doc talk. GNR drops new music. A Death Metal band get's it's biggest headlines and the 1st ever Bakko Guitarist of the Year. Pantheon Podcasts Reach out to us! Rate, review, and subscribe at Apple Podcasts: Cobras & Fire: Comedy / Rock Talk Show on Apple Podcasts Join our fanpage on Facebook: (2) Cobras ON Fire: Private Group | Facebook Click like and follow on Facebook: (2) Cobras & Fire: Rock Podcast | Chicago IL | Facebook Follow us on Instagram Follow us on Threads: @cobrasandfirepodcast • Threads, Say more Subscribe to our YouTube channel: Cobras & Fire Rock Podcast - YouTube Follow us on Bluesky: Cobras & Fire Podcast (@cobrasfirepodcast.bsky.social) — Bluesky Email us: Buy a shirt!:"Cobras and Fire Podcast" T-shirt for Sale by CobrasandFire | Redbubble | cobras and fire t-shirts - cobras fire t-shirts Buy Rock Candy! Freeze-Dried Candy pairs perfectly with the Cobras & Fire podcast. Specifically, candy from Esquilo Candies, a Youth-Run business founded and managed by LC's son. Crunch while rocking out! Stitcher: Cobras & Fire: Comedy / Rock Talk Show on Stitcher Spreaker: Cobras & Fire: Comedy / Rock Talk Show | Listen to Podcasts On Demand Free | TuneIn Find it all here: Cobras and Fire Podcast - Comedy Rock Talk Show Music: Wilson - Give Em Hell Van Halen - Get Up Oasis - Wonderwall W.A.S.P. - Sexdrive Extreme - Here's To The Losers Silverstein - Go Your Own Way Learn more about your ad choices. Visit megaphone.fm/adchoices
Bakko has some apologies. LC has some positivity. Jack White performs... LIVE! Daughtry disses Draiman. Oasis somehow trolls Machine Head. Nuthin' But A Good time doc talk. GNR drops new music. A Death Metal band get's it's biggest headlines and the 1st ever Bakko Guitarist of the Year. Pantheon Podcasts Reach out to us! Rate, review, and subscribe at Apple Podcasts: Cobras & Fire: Comedy / Rock Talk Show on Apple Podcasts Join our fanpage on Facebook: (2) Cobras ON Fire: Private Group | Facebook Click like and follow on Facebook: (2) Cobras & Fire: Rock Podcast | Chicago IL | Facebook Follow us on Instagram Follow us on Threads: @cobrasandfirepodcast • Threads, Say more Subscribe to our YouTube channel: Cobras & Fire Rock Podcast - YouTube Follow us on Bluesky: Cobras & Fire Podcast (@cobrasfirepodcast.bsky.social) — Bluesky Email us: Buy a shirt!:"Cobras and Fire Podcast" T-shirt for Sale by CobrasandFire | Redbubble | cobras and fire t-shirts - cobras fire t-shirts Buy Rock Candy! Freeze-Dried Candy pairs perfectly with the Cobras & Fire podcast. Specifically, candy from Esquilo Candies, a Youth-Run business founded and managed by LC's son. Crunch while rocking out! Stitcher: Cobras & Fire: Comedy / Rock Talk Show on Stitcher Spreaker: Cobras & Fire: Comedy / Rock Talk Show | Listen to Podcasts On Demand Free | TuneIn Find it all here: Cobras and Fire Podcast - Comedy Rock Talk Show Music: Wilson - Give Em Hell Van Halen - Get Up Oasis - Wonderwall W.A.S.P. - Sexdrive Extreme - Here's To The Losers Silverstein - Go Your Own Way Learn more about your ad choices. Visit megaphone.fm/adchoices
It's been a minute since we dropped a new podcast because Steve has been giggin with his new supergroup, Howl Owl Howl and he talks all about it. We dig into Aerosmith's newest success & possible future, plus the future of the concert industry in general and the new GnR songs, well, really just the one song
Why didn't George Clooney watch Thelma & Louise for years after it hit theatres? Kelly & Sharon uncover the surprising story featuring none other than Brad Pitt and break down the casting decisions that shaped the film into a 90s classic. This episode of 90's NOW also dives into: • Guns N' Roses and their big plans for 2026, including new music and a massive North American tour. • How GNR has kept things surprisingly stable over the last decade. • A look back at the early 90s, including the notorious Montreal riot after a GNR show went sideways. • The rise of Parental Advisory stickers and why they encouraged more listeners instead of fewer. • Simon Cowell's heartfelt comments following the tragic 2024 passing of Liam Payne and how early fame with One Direction impacted his life. Plus:
Become a supporter of this podcast: https://www.spreaker.com/podcast/the-good-morning-portugal-podcast-with-carl-munson--2903992/support.Need help in Portugal? Contact Carl by phone/WhatsApp on (00 351) 913 590 303, email carl@carlmunson.com or join the Portugal Club community here - www.theportugalclub.com
Dez militares da GNR, um agente da PSP e vários civis foram detidos na terça-feira, suspeitos de escravizarem e explorarem o trabalho de imigrantes ilegais. A maioria dos suspeitos manteve-se em silêncio no tribunal. O Governo vai criar uma Comissão de Combate à Fraude no SNS e escolheu o juiz Carlos Alexandre para a liderar. Numa sondagem do ICS/ISCTE feita para o Expresso e a SIC, Henrique Gouveia e Melo e André Ventura surgem como os favoritos a passar à segunda volta nas eleições presidenciais. Marques Mendes surgem em terceiro lugar, mas em empate técnico com os outros dois candidatos, numa altura em que ainda há uma grande percentagem de indecisos. São estes os temas do Eixo do Mal, em podcast, com Clara Ferreira Alves e Luís Pedro Nunes, Daniel Oliveira e Pedro Marques Lopes. Emitido na SIC Notícias a 27 de novembro. Para ver a versão vídeo deste episódio clique aquiSee omnystudio.com/listener for privacy information.
O alegado envolvimento de onze bombeiros na violação de um colega de 19 anos e a detenção de vários militares da GNR por suspeita de auxílio à imigração ilegal são os temas do Crime e Castigo desta semana. Um podcast com Paulo João Santos e João Amaral Santos, apresentado por Rita Fernandes Batista e editado por Maria Leonor Correia.
Hall of Fame drummer Matt Sorum returns! We discuss his upcoming "Sound and Vision" Awards. Plus, saving the Arts in public schools, new Aerosmith/Yungblud EP, Velvet Revolver with Macy Gray, GNR's cover of "Sympathy for the Devil," what the 40th anniversary of Guns N' Roses means, and more! More info: https://adoptthearts.org/ https://www.instagram.com/mattsorum/ Our website: www.afdpod.com
En este episodio de La Galería Nocturna Podcast nos sumergimos en lo que fue la última visita de Guns N' Roses a México, un concierto que retumbó en el Estadio GNP el pasado 8 de noviembre. A pesar del caos en los accesos y los precios por las nubes , la noche terminó siendo una auténtica joya para el corazón. A las 9:30 pm, GNR explotó sobre el escenario: Axl volvió con una voz mucho más sólida que en el Back to the Beginning Tour y con una actitud brutal; Slash, bueno… siendo Slash , reafirmando su estatus como uno de los guitarristas más icónicos del planeta; Duff, dándole al bajo como si quisiera romper el suelo. Y la banda entera, en modo rockear-o-morir. El setlist fue un viaje directo a la adolescencia: Welcome to the Jungle, Mr. Brownstone, It's So Easy, November Rain, Nighttrain, Paradise City… himnos que nos regresaron a esos días en los que teníamos 10 o 12 años, cuando descubrimos que el rock podía cambiarnos la vida . Un concierto cargado de emociones, nostalgia, recuerdos que duelen rico ✨… y también la sensación de que quizá presenciamos uno de los últimos grandes shows de lo que alguna vez fue la banda más peligrosa del mundo. Una locura total. Un abrazo al alma. Un capítulo que teníamos que contar. GothProds Links Spotify -https://open.spotify.com/show/2hnlgkcGNl9GOAPa0WT9HW?si=7e9b95f203464fe6 Apple Podcast — https://podcasts.apple.com/mx/podcast/goth-prods/id1606324255?l=en Amazon Music — https://music.amazon.com.mx/podcasts/d10f63b6-f4f3-4a91-b21d-d98c2b08ca01/goth-prods?ref=dm_sh_xBGgYoDaqnREmWm0IoJu5r4kd Facebook — https://www.facebook.com/Goth-Prods-104237088306624/ Instagram — https://www.instagram.com/goth_prods/ TikTok - https://www.tiktok.com/@goth_prods
Dave and Chuck the Freak talk about Men Make Dinner Day, Nacho Day, physical therapist did internal pelvic therapy to woman unnecessarily, alleged terror plot planned against Cedar Point, update on crashed UPS plane, thousands of flights being cancelled due to government shutdown, update on substitute teacher who showed up drunk, 12-year-old saved 5 people after boat capsized, gator in pond near neighborhood, influencer divorced former NFL player because dong was too big, UFC and FBI are working together to combat betting, Tom Brady cloning dog, Kim Kardashian show has 0% on Rotten Tomatoes, revolt at Miss Universe, Uma Therman's advice to daughter when working with Tarantino, Oprah's Favorite Things gift guide, Gwenyth Paltrow's gifts list, David Lee Roth, GNR trying to block former manager's tell-all book, update on McDonald's worker pulling gun on customers, woman stabbed teen at Foot Locker, guy threatened guy for taking too long in bathroom, man shot at house after someone called his lady a hoe, woman jumps into action when jumps into backseat of car, woman helped cop catch shoplifter, woman is living in home with a squatter, lawsuit over being called a Karen, places in your home you consider yours, fitness influencers can be too good looking, Dr Pepper sausage, someone thought they saw lion in the Irish woods, and more!See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
Dave and Chuck the Freak talk about Men Make Dinner Day, Nacho Day, physical therapist did internal pelvic therapy to woman unnecessarily, alleged terror plot planned against Cedar Point, update on crashed UPS plane, thousands of flights being cancelled due to government shutdown, update on substitute teacher who showed up drunk, 12-year-old saved 5 people after boat capsized, gator in pond near neighborhood, influencer divorced former NFL player because dong was too big, UFC and FBI are working together to combat betting, Tom Brady cloning dog, Kim Kardashian show has 0% on Rotten Tomatoes, revolt at Miss Universe, Uma Therman’s advice to daughter when working with Tarantino, Oprah’s Favorite Things gift guide, Gwenyth Paltrow’s gifts list, David Lee Roth, GNR trying to block former manager’s tell-all book, update on McDonald’s worker pulling gun on customers, woman stabbed teen at Foot Locker, guy threatened guy for taking too long in bathroom, man shot at house after someone called his lady a hoe, woman jumps into action when jumps into backseat of car, woman helped cop catch shoplifter, woman is living in home with a squatter, lawsuit over being called a Karen, places in your home you consider yours, fitness influencers can be too good looking, Dr Pepper sausage, someone thought they saw lion in the Irish woods, and more!
For Pete's Sake 11.01.25 - Three of the Most Important Stories of the Week
GnR- 14 Years
Militar da GNR morre em perseguição a traficantes. Nas Caraíbas, os EUA afundam barcos de droga quando detetados. É método a seguir? Este é o tema do ‘Crime e Castigo' de hoje, onde falamos também do trabalho de laboratório que levou à descoberta de um homicida e do assalto do século.Um podcast com Paulo João Santos e Sérgio A. Vitorino, apresentado por Rita Fernandes Batista e editado por Madalena Henriques.
Uma nova side em watch: Rita, ou Kiki para os amigos, traz o seu humor e estilo para o estúdio. Esta é mais uma semana onde há imensas perguntas para responder: É possível comida saudável saber bem? Deve-se comprar cães? Carlão estragou a homenagem aos GNR da Rádio Comercial? Além disso, Kiki humilha o dono do podcast com uma foto antiga e Pedro conta a sua experiência em solo mexicano.00:00 Intro00:23 Qual o tamanho ideal de iPhone?01:23 Revolta com volume da música no Honest Greens02:34 Honest Greens é saudável?04:12 Quem é Kiki Rivotti?07:01 Kiki traz fotografia antiga com PTM12:26 O que significa “manifesting”14:23 Análise de vision board do ano de Kiki20:51 Sofrimento em viagens de 11 horas de avião22:49 Como enganar o jet leg25:42 Evolução de PTM no México: 2007 vs 202529:24 Questão para o auditório: qual a população da Cidade do México?29:55 PTM e CCV não visitam Nápoles com medo35:15 Mexicanos vs Espanhóis36:29 Comida mexicana vs o resto39:15 Experiência de ver Tame Impala DJ set no México41:44 Comentários negativos no TikTok mexicano48:03 Porque é que a viagem de regresso é mais rápida do que a de ida?50:09 Estar envolvido no lançamento do álbum de Tame Impala53:36 Analógicas do México e explicação58:02 PTM foi ver lucha libre01:00:03 Team experimenta cacau puro do México01:03:42 Tipo de música que apetece ouvir na noite01:05:00 Apelo à limpeza de cartazes eleitorais01:10:19 Kiki faz apresentação sobre o seu novo cão01:14:13 Comprar cão vs adotar num canil01:17:35 Explicação sobre nome do novo cão01:21:30 Vantagens de ter cão01:25:16 Análise ao vídeo de homenagem da Rádio Comercial aos GNR01:38:56 México ou Japão?
Además Green Day, Ozzy Osbourne, The Who, Paul McCartney y los estrenos rock de la semana.
Billy McCloud is credited for co-writing the Guns N' Roses song "Yesterdays" from Use Your Illusion II. Sadly, Billy passed in 2002, but his sister Cynthia is here to share the story. Who was he? Why just "Billy" in the UYI II liner notes? What did Axl pay out in royalites? Cynthia McCloud is eager to let fans know who her brother was and how generous Axl is. A previously untold tale of one of GNR's most classic songs. More on Cynthia: https://www.instagram.com/whatagirleats/ https://whatagirleats.com/ Our website: www.afdpod.com
Dizzy is best known as the keyboardist for Guns N' Roses, with whom he has played, toured, and recorded since 1990. Beyond his tenure with GNR, he has collaborated with icons like Joe Perry, Psychedelic Furs, and Slim Jim Phantom. His contributions extend to revered records by Motorhead, Backyard Babies, and Armored Saint. Influenced by rock legends of the '60s and '70s, he honed his skills through performances at local venues. His journey led him to Los Angeles, where he conquered the famed 'Sunset Strip' stages. In 2018, he unveiled his solo debut, 'Rock 'N Roll Ain't Easy,' earning critical acclaim. He remains driven, drawing inspiration from diverse genres, and recently released his second solo album, Rock 'N' Roll Chose Me.
Once upon a time in Hollywood, David Bowie made Axl Rose so mad that it nearly caused a brawl in the middle of the street! Get into the story of this very rock ‘n roll moment in this bonus episode of the Behind The Song podcast. See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
The Podcast That Rocked for 8/13/25. Ranking the iconic seven rock albums from a 7 week span in 1991, news on My Chemical Romance, Mastodon, more. Discussion Topics:Ranking Iconic Seven Rock Albums Of 1991Bloodstock 2025 looked amazingHatebreed's Wayne Lozinak recoveringBrent Hinds REALLY Hates MastodonAttila's Fronz makes good on dumb challenge to Mr. BeastMy Chemical Romance to perform at WembleyAlbum VS Album, Upcoming Albums/Tours, more SONG OF THE WEEK: BABYMETAL “Sunset Kiss” = https://tidal.com/browse/track/452164699?uALBUM VS ALBUM POLL: System Of A Down Toxicity VS. Slipknot Self-Titled = https://www.youtube.com/post/UgkxYUbuiHh9QPCWvCMheAc6d_30dOhCuvhg “These seven albums are an excellent example of the rapid transformation of rock ‘n' roll from the glammed-out excesses of hair metal to the stripped-down, antiestablishment aesthetics of the diverse set of bands given the convenient umbrella term “grunge.” Even the entries from Metallica, the Chilis, and GNR, though definitely not grunge, felt unique and, most importantly, authentic.” (Sweetwater) Hosted by:Luke = https://bsky.app/profile/rockednet.bsky.socialAlex = https://bsky.app/profile/voiceofalex.bsky.socialRowan = https://bsky.app/profile/rowbuck01.bsky.social Ranking The Iconic Seven Rock Albums From 1991 | The Podcast That Rocked
When Chip Z'Nuff showed up on local timelines crushing the music of Guns N' Roses with tribute band Pretty Tied Up last month in Fallston, we knew it was time to relive the magical mystery tour of peace and love and Hammerjacks memories. The new thing is always the best of the old things and Chip returns as the living embodiment of the power of "sex, drugs and rock and roll" – in moderation and not necessarily in that order – to discuss modern touring, his time with Steven Adler and new Enuff Z'Nuff music with Nestor. The post Rocker Chip Z'Nuff returns to discuss modern touring, power of GNR and new Enuff Z'Nuff music with Nestor first appeared on Baltimore Positive WNST.
Newberg pod is a show where comedian and writer, J Chris Newberg, interviews Rock Stars and Famouses from his kitchen table. Today on the show bassist and principle songwriter for the multi platinum rock band Skid Row, Rachel Bolan sits down to discuss: In Jersey, did Tommy & Gina (From Living' On A Prayer) know Ricky from (18 & Life?) - Is Yungblud the last rockstar? Best ways to smell fresh on the road, touring with Kiss, GNR,Van Halen, Aersosmith, Motley Crue as well the highs and lows of the music biz. They are on the lookout for a new singer. Could it be you?! You heard it here first. Check out The Newberg Pod. if you enjoy it, give it a like and a follow - Wherever you stream as well as right here on youtube @NewbergPod https://youtu.be/0w-gs0zcWbc Follow Rachel on instagram @officialrachelbolan and follow J Chris Newberg @thechrisarmy #SkidRow #RachelBolan #Newberg #Funny #Interview
Back from Birmingham, UK and the monumental Back To The Beginning concert, Daniella asks Barbaranne to share leaving no stone unturned. The epic sendoff of Ozzy Osbourne and Black Sabbath had no less than Rival Sons, Gojira, Halestorm, Mastodon, Alice In Chains, Pantera, GnR, Slayer and Metallica pay tribute to the originators of Metal, Black Sabbath. Ozzy did sets with the No More Tears band, including Zakk and then finished the nearly 11 hour concert with the original Black Sabbath, ending in fireworks and quite a lot of tears. Listen in to hear Barbaranne's recount. Cheers and Check Out More Shows! Learn more about your ad choices. Visit megaphone.fm/adchoices
Alan Niven discusses his experiences as a manager and producer, particularly with Guns N' Roses and Great White. He highlights the challenges of managing Axel Rose's erratic behavior and the impact of losing key members like Izzy Stradlin. Niven emphasizes the importance of maintaining anonymity and the emotional toll of fame. He reflects on the band's decision to release two single albums instead of a double album, citing economic and creative reasons. Niven also touches on the band's struggles with substance abuse and the significance of maintaining a cohesive band dynamic.0:00:00 - Intro0:00:21 - Night Train & Drinking 0:00:58 - Alan's Many Roles in the Music Industry 0:04:15 - Guns 'N Roses, Axl, Songwriting & Emotion 0:09:00 - GnR, Izzy, Axl, Fame, Anonymity & Happiness 0:19:55 - When Axl Didn't Want to Perform 0:26:07 - If Alan Stayed On, Izzy Leaving & Axl's Grudges 0:34:35 - Izzy's Whereabouts and Slash's 50s0:38:30 - Original GnR United, Axl Psychology & Beta 0:43:40 - Sweet Child O' Mine Video & Erin Everly 0:45:20 - Transitioning into the 90s with GnR 0:47:52 - Pressure from David Geffen 0:51:05 - Use Your Illusion Albums & Songs 0:57:15 - Memories, Memorabilia, Happiness & Success1:00:10 - Sound 'n Fury & Wrapping Up 1:02:02 - Outro Sound N Fury book for sale:https://www.amazon.com/Sound-Fury-Rock-Roll-Stories/dp/1770419942Chuck Shute link tree:https://linktr.ee/chuck_shuteSupport the showThanks for Listening & Shute for the Moon!
In a heartfelt conversation, Taime Downe opens up about coping with the loss of his fiancée Kim and how it reinforced his commitment to sobriety. Despite tour challenges, including an early bus breakdown, he's finding strength through music and his band family. Downe also discusses Faster Pussycat's latest single 'Motorbike,' their approach to releasing new music, and their extensive upcoming tour with The Supersuckers.Plus, former Guns N' Roses and Sixx:AM guitarist DJ Ashba discusses his innovative venture into GDM, blending rock guitar with dance music. He shares insights about performing at Vegas clubs, his creative process, and the challenges of bridging two distinct musical worlds. Ashba also discusses the status of Sixx:AM, his memorable moments with GNR, and how his successful fabrication business allows him creative freedom to explore new musical territories. Catch Eddie Trunk every M-F from 3:00-5:00pm ET on Trunk Nation on SiriusXM Faction Talk Channel 103.And don't forget to follow Eddie on Twitter and Instagram!Follow the link to get your free 3-month trial of SiriusXM: http://siriusxm.com/eddietrunk Find all episodes of Trunk Nation: https://siriusxm.com/trunknation
Chuck Shute and Martin Popoff discuss Popoff's book on Guns N' Roses, highlighting its unique photos and the collaboration with his editor, Dennis. Popoff has written 130 books, with 40% of his income from mail orders. They delve into the band's history, including the challenges of updating books and the impact of grunge on hair metal. Popoff emphasizes Axl Rose's dedication to creativity and the band's evolving sound. They also touch on the band's interactions with other musicians and the enduring influence of Guns N' Roses' music. Martin Popoff discussed his new book on Guns N' Roses, set to release by mid-June, with pre-orders available on Amazon and his website, where he signs and ships copies. He mentioned his prolific YouTube channel, "The Contrarians," and his audio-only podcast, "History and Five Songs with Martin Popoff," which has 308 episodes. Popoff also highlighted his involvement in other podcasts, including an AC/DC podcast with John Gaffney and appearances on Brian Slogale's "100 Most Important Songs" series. Chuck Shute concluded the conversation by thanking Popoff and mentioning the upcoming episode release.0:00:00 - Intro 0:00:20 - New GnR Book & Pics 0:02:05 - Writing Books & Updating Them 0:04:23 - Mailbox Money, Royalties & Best Books 0:06:54 - Guns 'N Roses At 40 0:08:34 - Early Guns 'N Roses, Name & Genre 0:16:55 - Shaking Up Rock, Hair Metal & Grunge 0:21:00 - Use Your Illusions 0:24:20 - Production & Sound of Appetite 0:28:25 - Possible New GnR Album & Izzy 0:30:10 - GnR, Motley Crue & Musical Connections 0:31:50 - Music Scene, Moving to L.A. & Evolution of Streaming 0:35:47 - New Bands, Cult Bands & Standing Out 0:42:28 - Axl Rose, Creativity & Time Lapses 0:45:25 - Tommy Stinson on Axl's Strengths & Weaknesses 0:47:03 - Interviewing Big Rockstars Like Axl & Izzy 0:55:50 - Fan of Hair Metal & Grunge & Evolution of Rock 1:02:03 - New Book, Pre-Ordering, Youtube & Podcast1:03:52 -Outro Martin Popoff website:https://martinpopoff.com/html/bookslistChuck Shute link tree:https://linktr.ee/chuck_shuteSupport the showThanks for Listening & Shute for the Moon!
Finnish rock legend Lauri Ylönen of The Rasmus joins. We chat their new album "Weirdo" and what it means to be "weird." Plus, Lauri talks about starting the band at only 14, love for GNR's Use Your Illusion, thoughts on music leaks, and more! More info: https://therasmus.com/ https://www.youtube.com/watch?v=dj_kypliLno Our website: https://afdpod.com/ Theme music by Mike Squires
Send us a textStrap in, degenerates. In this brutally honest, no-holds-barred episode of Ones Ready, we sit down with Recon Marine, The War Journal author, intelligence community insider, and potential future Ambassador to Afghanistan—James. Freakin' Sisco.This isn't your average “rah-rah” war story episode. Sisco takes us deep into the grit and grime of Desert Storm, recounts the absolute hilarity of rolling into combat with Oakleys and Guns N' Roses, and then slams you into an emotional brick wall with betrayal, loss, and the aftermath of trauma stuffed into a rucksack for 30 years.From saving lives with a handwritten journal to calling BS on the Medal of Honor fame train, Jim serves up reality checks hotter than a desert MRE. He even casually drops that he's running a global risk advisory firm, trying to be Charge d'Affaires to Afghanistan, and working on a freakin' miniseries with the Marine Corps.This episode is raw. It's hilarious. It's painful. It's human. It's what happens when the mission ends and the real battle begins—with yourself.
It's painful when the memories return too suddenly. It's less painful when we're stealing villagers for mining work, blowing up a tombstone, revealing Chris' ultimate weirdo secret, counting action figures, seeding rumors of a beautiful singer, shaking the faith of the faithful, extracting lore from the library, taking over the world for non-sexual reasons, psychologically torturing mom, realizing Alex is the last potential Dragon Master, guessing the next three plot points, mistrusting handsome men, confusing GnR with AC/DC, and yanking buns out of a fire. Whatever the problem is, the books will always have an answer. 00:00:00 Suiko Promo 00:02:07 Intro 00:03:50 Burg-er Time 00:05:40 Saith-er Time 00:14:58 Nanza Barrier Time 00:17:43 Lann-er Time 00:18:40 Althena's Shrine-r Time 00:20:43 Vane-r Time 00:24:45 Magic Guild-er Time 00:44:46 Panic In Meribia 00:47:41 Real Net 00:52:30 Outro Patreon: patreon.com/retroam Bluesky: @retrogradeamnesia.bsky.social YouTube: www.youtube.com/@RetrogradeAmnesia E-Mail: podcast@retrogradeamnesia.com Website: www.retrogradeamnesia.com