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Enerji ve teknoloji alanlarında iş yönetimi danışmanlığı faaliyetlerinde bulunan, multidisipliner kamu politikaları üreten Glocal Grup Danışmanlık'ın sunduğu  Varsayılan Ekonomi'nin Soru-Cevap Yayını'nda Ekonomist Dr. Enes Özkan ve Enerji Uzmanı Eser Özdil, İran Savaşı ve Hürmüz Boğazı'nın kapatılması bağlamında enerji güvenliği sorunu, yükselen akaryakıt fiyatları ve bu gelişmelerin dünya ve Türkiye ekonomisine etkileri konularında merak ettiğiniz soruları cevaplıyor. Bu gönderinin altına sorularınızı yazabilirsiniz.https://groupglocal.com/contact/ #reklam #işbirliği00:00 Giriş02:30 Bir deponun kaça dolacağı nasıl belirleniyor?07:40 EŞEL Mobil Sistemi nedir, ne zaman devreye girer, ne kadar etkili olabilir?12:05  Trump sonrasında Paris Anlaşması ve geniş anlamda çevreci enerji devrimi sekteye uğradı mı?19:40 2026'da elektrik-gaz sübvansiyonu olarak öngörülen 500 milyar lira yeterli gelecek mi?23:10 Hürmüz Boğazı'nın kapatılması Avrupa enerji piyasalarını ve Avrupa'da enflasyonu nasıl etkiler?32:10 Çin, Hürmüz Boğazı'nın kapatılması nedeniyle ihtiyacı olan petrolü başka yerlerden hızlı bir şekilde tedarik edebilir mi? 34:10 70'lerdeki petrol krizi gibi bir kriz çıkması için varil fiyatı kaç dolara çıkması gerekir?37:40 AB'nin Rusya`dan petrol/doğalgaz alımı için Ukrayna'daki boru hatlarını kullanmak isteğine Ukrayna'nın olumsuz cevap verdiği söyleniyor. Türkiye burada devreye girebilir mi?46:20 Libya petrol üretimi İç Savaş öncesi seviyeye ne zaman çıkar?47:45 Rusya'nın yerine enerji tedarikçisi ya da hub'ı olmak gibi bir hedefimiz var mı?54:00 Enerji açığımızın giderilmesinde doğal kaynaklardan yararlanılması konusundaki engeller nelerdir? Doğal kaynaklarımız mı yetersiz?01:01:00 Brentteki artışın Türkiye'ye daha fazla yansımasının ne kadarı bizim döviz kuru ve vergilerimizle ilgili?01:02:30 İran vanayı kısarsa veya Hürmüz Boğazı'nda kriz çıkarsa Türkiye'nin arz güvenliği bundan nasıl etkilenir? 70'lerdeki gibi bir kıtlık yaşama riskimiz var mı?01:06:00 ABD'nin Venezuela politikası veya kaya gazı üretimi şu anki fiyatları dizginlemeye yetmiyor mu?01:09:50 VIX endeksi niye düşüşte? (YTD)01:11:35 Petroldeki durum petrol bazlı plastiklerde de fiyat artışına neden olur mu?01:12:10 Körfez'in tarafsız, güvenli ve lüks imajı yara aldı mı?01:15:40 "Kardeş Ülke İspanya" enerji piyasası ne durumda? (keyifler yerindeymiş :)01:19:05 Körfez ülkeleri bir süre petrol-gaz satmasa da idare edebilirler ancak deniz suyu arıtma tesislerine elektrik sağlayan enerji santrallerinin petrol-gaz arzı & Hürmüz Boğazı'ndan yapılan gıda sevkiyatları durursa bu ülkeler ne kadar dayanabilecekler?01:21:50 Özel sektörün perakende su temini (pet şişe sular) işletmeciliği, özellikle yeni dönemde bölgesel su kaynakları ve enerji bakımından bir güvenlik sorunu oluyor mu, olacak mı?Ayrıcalıklardan yararlanmak için bu kanala KATILın (IOS kullanan takipçilerimiz de artık kolayca KATILabilirler):https://www.youtube.com/channel/UCWyDy24AfZX8ZoHFjm6sJkg/joinBizi Patreon'dan Destekleyin

Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.

We're getting a look at more videos from the Epstein Files, including hours of footage from a 2010 deposition for a civil lawsuit filed by an alleged victim. Law&Crime's Jesse Weber analyzes the most telling moments from the hours-long back-and-forth, including Epstein's refusal to directly answer questions about his co-conspirator Ghislaine Maxwell, his properties, and his alleged sexual crimes.PLEASE SUPPORT THE SHOW: Go to https://meetfabric.com/sidebar and apply today, risk-freeHOST:Jesse Weber: https://twitter.com/jessecordweberLAW&CRIME SIDEBAR PRODUCTION:YouTube Management - Bobby SzokeVideo Editing - Michael Deininger, Christina O'Shea, Alex Ciccarone, & Jay CruzScript Writing & Producing - Savannah Williamson & Juliana BattagliaGuest Booking - Alyssa Fisher & Diane KayeSocial Media Management - Vanessa BeinSTAY UP-TO-DATE WITH THE LAW&CRIME NETWORK:Watch Law&Crime Network on YouTubeTV: https://bit.ly/3td2e3yWhere To Watch Law&Crime Network: https://bit.ly/3akxLK5Sign Up For Law&Crime's Daily Newsletter: https://bit.ly/LawandCrimeNewsletterRead Fascinating Articles From Law&Crime Network: https://bit.ly/3td2IqoLAW&CRIME NETWORK SOCIAL MEDIA:Instagram: https://www.instagram.com/lawandcrimeTwitter: https://twitter.com/LawCrimeNetworkFacebook: https://www.facebook.com/lawandcrimeTwitch: https://www.twitch.tv/lawandcrimenetworkTikTok: https://www.tiktok.com/@lawandcrimeSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Michael Cohen reacts to Hillary Clinton's deposition spiraling out of control after Rep. Lauren Boebert leaked photos from inside the room, despite James Comer insisting no press or media would be allowed. MAGA scrambles to contain the damage from yet another self-inflicted embarrassment. Learn more about your ad choices. Visit megaphone.fm/adchoices

Berlinale'de Gazze gündemi, Depo'da Ekolojik Yıkıma Karşı belgeseller; 10 Usta 10 Albüm konserlerinde cazın duayenlerinden dinletiler, Paribuart'ta Beyaz Tavşan Kırmızı Tavşan gösterileri, Moda Sahnesi'nde Bir Kadının Kavgaları ve Dönüşümleri. Kent Takvimi etkinlik öneriyle dopdolu.

Patrick Bet-David, Tom Ellsworth, Adam Sosnick, and Vincent Oshana are joined by Representative Randy Fine as they break down the America First vs Israel First debate, Les Wexner's Jeffrey Epstein testimony, Trump's Iran nuclear deal deadline, the Supreme Court ruling against Trump tariffs, Tucker Carlson being detained in Israel, and Elon Musk agreeing with the teachings of Jesus.------✝️ FAITH OVER FEAR COLLECTION: https://bit.ly/4aM3UaiⓂ️ CONNECT ON MINNECT: ⁠⁠⁠⁠⁠https://bit.ly/4kSVkso ⁠⁠⁠Ⓜ️ PBD PODCAST CIRCLES: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bit.ly/4mAWQAP⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Haftalık programında Fatma İnce ve Mert Büyükkarabacak geçtiğimiz haftanın politik gelişmelerini değerlendiriyor:→ ABD-İran görüşmeleri→ Kuzey Afrika önem kazanıyor: Polisario Cephesi'ne özerklik→ Münih Güvenlik Konferansı: Kürt heyetinin Münih çıkarması→ Meclis Komisyonu raporu, Kürt sorununun çözümü için ileri bir adım mı?→ Sosyal medyada kimlik doğrulama uygulaması → Ramazan'da zam yağmuru → Depo işçilerinin direnişi, nasıl bir sınıf mücadelesi verilmeli?→ Berlin film festivalinde sanat ve politika tartışmaları→ Okuma ve izleme önerileri

Você sabe explicar em detalhes como sua empresa ganha dinheiro?Neste episódio do Podcast Mulheres de Produto, Rúbia Macedo conversa com Erika Oliveira sobre a transição de Product Owner para Product Manager  e o que realmente separa quem entrega software de quem gera resultado.Falamos sobre:• A virada de mindset do operacional para o estratégico• Como desenvolver visão de negócio como hábito• Discovery com foco em ROI• Como ganhar influência e falar a língua do negócio• Por que a dor do produto não é backlog: é falta de clareza de resultadoUm episódio prático, direto e provocador para quem quer assumir uma postura mais estratégica na carreira.Conecte-se com a Erika:https://www.linkedin.com/in/oliveira-erikaCompartilhe com aquela amiga que está vivendo essa transição.Apresentação: Rubia MacedoEdição: Isabella Yoshimura

1. Premiér za krčmové reči schováva neistotu 2. V koalícii sa už otvorene bijú o voliča 3. Fico má palicu na predsedu PS

The Rush Hour — Afternoon Edition Sponsored by Wayfair. wayfair.com Justin Baldoni vs. Blake Lively heats up as new depositions drop, revealing absolute insanity behind the scenes and what it was really like on set Former Bachelor Colton Underwood is back in the spotlight on Traitors, and the internet is revisiting the wild drama from his original Bachelor season Trump reignites chaos with comments about Greenland, and a Danish politician goes fully unfiltered, telling him to go F himself Power, fame, ego, and international clapbacks — we break it all down with context and comedy

Rush Hour — Afternoon Edition: Scandals, Seizures & Shootings — Blake Lively vs. Justin Baldoni explodes into another legal battle with new filings and sealed court drama — what are they trying to hide and who's being protected? Plus, the U.S. pulls off a dramatic high-seas move, seizing a Russian-flagged oil tanker tied to Venezuelan oil sanctions — why it matters in the broader sanctions fight. Then we break down growing government pressure on the press, from Pentagon reporting restrictions to White House "hall of shame" tactics aimed at reporters — is this shaming or chilling free speech? And in Minnesota, breaking news: an ICE agent fatally shot a civilian during a large federal immigration operation in Minneapolis — what we know, what's in dispute and how local leaders are reacting. Tune in for context, heat, and the stories behind the headlines. Sponsored by Gobymeds. Go to gobymeds dot com code rushhour for $50 off

durée : 00:24:54 - Les Nuits de France Culture - par : Albane Penaranda - C'est un récit de la vie de Paul Verlaine émaillé par la lecture de ses poèmes les plus célèbres que propose cette émission "Faites vous-même votre anthologie", diffusée en 1955 sur la Chaîne parisienne. - réalisation : Thomas Jost

durée : 00:47:10 - La 20e heure - par : Eva Bester - Chantre d'une pensée du divers et de la relation, Patrick Chamoiseau vient de publier "Que peut Littérature quand elle ne peut ?" au Seuil. Lui qui se disait "guerrier de l'imaginaire" s'interroge encore sur les pouvoirs de la création artistique face à l'ordre néo-libéral du monde tel qu'il va. - invités : Patrick Chamoiseau - Patrick Chamoiseau : Écrivain - réalisé par : Lola COSTANTINI Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.

Special Counsel Jack Smith is demanding the immediate release to the American Public of a previously unknown 9 hour VIDEO TAPE of his sworn testimony to Congress where he laid out in excruciating detail the evidence “beyond a reasonable doubt” that Trump is a criminal. Michael Popok reports on the new demand and the MAGA House's expected rejection of it, making Smith the only Special Counsel not to have delivered the results of his report in public during a hearing. Remember to subscribe to ALL the MeidasTouch Network Podcasts: MeidasTouch: ⁠https://www.meidastouch.com/tag/meidastouch-podcast⁠ Legal AF: ⁠https://www.meidastouch.com/tag/legal-af⁠ MissTrial: ⁠https://meidasnews.com/tag/miss-trial⁠ The PoliticsGirl Podcast: ⁠https://www.meidastouch.com/tag/the-politicsgirl-podcast⁠ Cult Conversations: The Influence Continuum with Dr. Steve Hassan: ⁠https://www.meidastouch.com/tag/the-influence-continuum-with-dr-steven-hassan⁠ Mea Culpa with Michael Cohen: ⁠https://www.meidastouch.com/tag/mea-culpa-with-michael-cohen⁠ The Weekend Show: ⁠https://www.meidastouch.com/tag/the-weekend-show⁠ Burn the Boats: ⁠https://www.meidastouch.com/tag/burn-the-boats⁠ Majority 54: ⁠https://www.meidastouch.com/tag/majority-54⁠ Political Beatdown: ⁠https://www.meidastouch.com/tag/political-beatdown⁠ On Democracy with FP Wellman: ⁠https://www.meidastouch.com/tag/on-democracy-with-fpwellman⁠ Uncovered: ⁠https://www.meidastouch.com/tag/maga-uncovered⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Açık Dergi'de Türkiye Tiyatro Vakfı Başkanı Esen Çamurdan ile Depo'da yer alan 'Tiyatro Hazinemizden' sergisini konuşuyoruz. Sergi, kurulması için destek beklenen Türkiye Tiyatro Müzesi'nin bir 'provası'. 

durée : 00:25:10 - Anne-Sophie Mutter, violoniste (5/5) - par : Judith Chaine - Dans ce dernier épisode, la violoniste Anne-Sophie Mutter explore sa passion pour la musique contemporaine, sa vision de l'engagement artistique ainsi que de la transmission aux générations futures. - réalisé par : Adrien Roch Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.

01 - HADEN x Szecsei - Cherokee 2025 (Intro Version) 02 - DESH X Young Fly X Azahriah - PANNONIA (CrazyBoys Remix) 03 - Travis Scott - FE!N (Rudeejay & Da Brozz Bootleg) 04 - Dr. Dre & Snoop Dogg - The Next Episode (Josh Le Tissier Techno Remix) 05 - Skrillex & Habstrakt - Chicken Soup (HADEN X Szecsei Remix) 06 - R3SPAWN & Nia Mousai - Bad Romance (Extended Mix) 07 - Jaxomy x Agatino Romero x Raffaella Carrà - Pedro (Szecsei x Thomas Rush Edit) 08 - Bellini x Matty Ralph - Samba Do Brasil x No Whistle, No Party (Rudeejay & Da Brozz x EDMMARO Mashup) 09 - 50 Cent - In Da Club (RobxDan Extended Remix) 10 - Jaden Bojsen & David Guetta - Let's Go (Scotty Extended Mix) 11 - Eminem vs R3SPAWN - Without Me vs E (Josh Le Tissier Mashup) 12 - Pogány Induló x Parno Graszt - Székelykapu (B00ST Hypertechno Remix) 13 - MilleniumKid x JBS - Vielleicht Vielleicht (Scotty Extended Mix) 14 - RobxDan & Consilium - Maria (I Like It Loud) (Extended Mix) 15 - Anyma & Argy & Son of Son - Voices In My Head (MR.BLACK Remix) 16 - Benny Benassi - Satisfaction (BEAUZ Hard Techno Remix) 17 - Jengi feat Nokia - Bel Mercy (BEAUZ Hard Techno Remix) 18 - BEAUZ - Ocho (Extended Mix) 19 - Creeds - Push Up (Szecsei & Dante Edit) 20 - DESH & KKevin & Young Fly X Tiesto - Bandana X Free Your Mind (HADEN Mashup) 21 - Timmy Trumpet x Macklemore - Cant Hold Us x Freaks (Seb Barras Mashup) 22 - Azahriah és DESH X Steve Angello - Mind1 X Knas 2024 (HADEN Mashup) 23 - BLACKPINK - JUMP (Antoine Delvig Rework) 24 - DESH & Young Fly X Restricted - Pakisztáni Popo X Thriller (HADEN Mashup) 25 - John Newman - Love Me Again (N4C Techno Edit) 26 - ABBA - Gimme Gimme Gimme (ANASTOVSKII Edit Cut) 27 - Ricchi e Poveri - Sarà Perché Ti Amo (Szecsei & Darwin Bootleg)

Enerji Günlüğü Haber Bülteni:Türkiye'nin ve Dünyanın Enerji Gündemienerjigunlugu.net

If you suffer from severe menstrual cramps, this is for you. Find out how to stop menstrual cramps naturally by addressing the root cause with these 13 natural remedies for period pain. Never experience menstrual cramps again! 0:00 Introduction: How to reduce period pain0:23 What is a menstrual cramp? 1:30 What causes severe period cramps? 6:42 Vitamin D3 and painful menstrual cramps 12:38 13 natural remedies for period painToday, I'm going to show you how to relieve period cramps fast, and for good. There are two types of period cramps: the primary type is labeled idiopathic, and secondary cramps that are caused by fibroids, ovarian cysts, or endometriosis.Many women take NSAIDs, birth control pills, and Depo shots for period pain relief. The medical community generally discourages the use of natural remedies for menstrual cramps, but does not discourage the use of medication. Research has shown the effectiveness of vitamin B1 and vitamin E.Upon searching for the root cause, I stumbled upon the following clues:• Painful cramps are caused by pain chemicals called prostaglandins. • Vasopressin, which causes contractions and decreased blood flow, is elevated when you have menstrual cramps.• Painful period cramps are associated with high parathyroid hormone levels. • Women with painful menstrual cramps also have much higher inflammation in the uterus, often related to NF-KB. • Black women have a 33% higher likelihood of getting severe period cramps than white women. • Menstrual cramps are sometimes treated with calcium channel blockers. This led to the conclusion that the root cause of menstrual cramps is a severe vitamin D3 deficiency! Try the following natural remedies for period pain and say goodbye to menstrual cramps for good:1. Take 20,000 IU of vitamin D3 daily2. Take 400-600 mg of magnesium glycinate 3. Follow a low-carb diet4. Intermittent fasting5. Cod liver oil for pain relief6. Vitamin E7. Vitamin B18. Increase iron with red meat9. Zinc for vitamin D3 absorption10. Exercise11. Fenugreek12. Heating pad13. Ginger Dr. Eric Berg DC Bio:Dr. Berg, age 60, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the Director of Dr. Berg Nutritionals and author of the best-selling book The Healthy Keto Plan. He no longer practices, but focuses on health education through social media.Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients, so he can focus on educating people as a full-time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose, and it is not a substitute for a medical exam, cure, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition.

Ep. 226, Nov. 11, 2025: On this episode we discuss the Browns Fail, Depodesta Out, NFC West Best, AFC Threats, Brian Daboll, Heisman Moments & More

durée : 00:41:36 - Les Nuits de France Culture - par : Christine Goémé - Par Jacques Meyer - Lectures Jean Négroni et Michel Bouquet d'une nouvelle de Georges Duhamel et de poèmes de Henry de Montherlant et de Jean Giraudoux - Réalisation Philippe Guinard - réalisation : Virginie Mourthé

Paul Depodesta has left the Cleveland Browns to return to Major League baseball with the Colorado Rockies. Depodesta became a hated figure to Browns fans with most of them not actually having any idea what his actual job was. The Browns head to New Jersey to face the Jets on Sunday and while most want the team to tank if the Browns do string together some wins to close out the season it will be a tremendous lift to the young core of players currently here who are trying to get this team competitive for a multiyear stretch. To learn more about listener data and our privacy practices visit: https://www.audacyinc.com/privacy-policy Learn more about your ad choices. Visit https://podcastchoices.com/adchoices

Today I'm talking with Tiffany Chow, jewelry artist and founder of Depo Market on Maui — a beautiful little shop that's part boutique, part community, and entirely built from love.Tiffany's path has been anything but ordinary. After studying at the School of the Art Institute of Chicago and running a successful jewelry line in New York, she felt an intuitive pull to move home to Hawaii. That decision led her to care for her brother, Chris — and ultimately to build a business that creates meaningful work for people with disabilities while bringing awareness and connection to her island community.In this conversation, Tiffany shares how Depo Market began as a pop-up for Chris and grew into a mission-driven storefront. We talk about caregiving, art as a bridge for belonging, and the realities of running a small, heart-centered business on Maui while raising a young daughter. It's a story about purpose finding you when you least expect it — and how one act of love can ripple out to change everything.Follow Tiffany:Instagram: @depo_marketTikTok: @depomarketWebsite: depomarket.orgLove the Podcast?Support an episode: ⁠⁠⁠⁠Click here to learn more!⁠⁠⁠⁠Without your support I couldn't continue the Slowmade Podcast. Thank you so much!Follow Christine and Slowmade...Instagram: ⁠⁠⁠⁠@christinemighion⁠⁠⁠⁠Jewelry Website: ⁠⁠⁠⁠christinemighion.com⁠⁠⁠⁠Slowmade: ⁠⁠⁠⁠slowmadepodcast.com

Episode 217: L'évolution de la poésie andalouse du Muashshah au Zajal : deux genres de poésie chantés dans la « Nouba » Préservée et développée en Algérie après l'expulsion des Maures d'Espagne au 15ème siècle, la musique andalouse est un héritage culturel originaire d'Al-Andalus qui a prospéré dans plusieurs régions du Maghreb jouant un rôle très important en tant que référence culturelle en Algérie par son profond enracinement dans l'histoire et dans l'identité du pays. Cette forme musicale s'est répandue au fil du temps au Maghreb, où elle a évolué et s'est adaptée aux cultures locales. Elle est composée de formes poétiques tels le Muwashshah ou le Zadjal. L'évolution de cette poésie a épousé de près le contexte des développements historiques et des bouleversements auxquels la société andalouse a fait face. Huit siècles sur le sol andalou, le muwashshah et le Zadjal s'épanouissent admirablement, de la conquête Omeyyade au 8ème siècle (de 711à 1031) jusqu'au règne de la dynastie arabe des Nasrides de Grenade du 13ème au 15ème siècle (de 1238 à 1492). Sans omettre le fait que bien avant la chute de Grenade, de nombreux musiciens musulmans s'étaient repliés en Afrique du Nord où cette tradition musicale arabo-andalouse s'est développée jusqu'à nos jours, particulièrement dans les villes ayant accueilli les réfugiés andalous.  Dans ce podcast, Lamia Fardeheb Bendimred, Attachée de recherche au Centre de Recherche en Anthropologie Sociale et Culturelle (CRASC) et qui mène des travaux sur les évolutions linguistiques dans la poésie populaire (Melhoun, Zajal Andalous, ...), se penche sur quelques exemples de poèmes issus de ces différentes périodes pour mettre en lumière les principales étapes de l'évolution de la poésie andalouse, en insistant sur les transformations, parfois profondes, qu'a connues la langue du Zadjal. Ce dernier se distingue en effet par une structure poétique particulière, caractérisée par l'emploi de l'arabe parlé et l'usage de schémas de rimes ainsi que de vers courts. Cet épisode s'inscrit dans le cadre de la journée d'étude intitulée « Chants et musiques d'Algérie : un fait social », organisée conjointement par Centre d'Études Maghrébines en Algérie (CEMA) et le Centre de Recherche en Anthropologie Sociale et Culturelle (CRASC) le 15 décembre 2024. Pr. Karim Ouaras, Université d'Oran 2 / CEMA a modéré le débat. * Podcast en relation: Episode 214: Introduction à la journée d'études « Chants et musiques d'Algérie : un fait social » Nous remercions infiniment Mohammed Boukhoudmi d'avoir interprété un morceau musical de « Elli Mektoub Mektoub » pour l'introduction et la conclusion de ce podcast. Montage : Hayet Yebbous Bensaid, Bibliothécaire / Chargée de la diffusion des activités scientifiques (CEMA). 

Auditeurs : MARYLINE : 22H32/22H59 En devenant socio-coiffeuse, Maryline a trouvé sa place. https://www.ligue-cancer.net/70-hautesaone   BRUNO : 23H04/23H23  Handicapé, Bruno doit trouver un nouveau logement et craint de finir à la rue.   PAUL : 23H28/23H59 Paul a construit son existence sur les traumatismes de guerre de son père.   LOU : 00H04/00H23 Amatrice de poésie, Lou propose à Roland un soin poétique. https://www.lachouetteimprevue.com/product-page/jai-besoin-d%C3%AAtre   ODETTE : 00H28/01H00 Odette est aveugle et folle de lecture. Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

Podcast Description: In this afternoon's episode of The Rush Hour, the suspected shooter in the Charlie Kirk assassination has been caught. We break down everything we know so far, plus highlights from the brave speech given by the Utah governor in response to the tragedy. Also on the docket: the latest courtroom drama between Blake Lively and Justin Baldoni, as Taylor Swift is officially set to be deposed, and Rachel Kirkconnell speaks out following the new Bachelorette announcement. Bullet-Point Summary: Suspected shooter in the Charlie Kirk case has been caught — full update and details Utah governor delivers a brave and unifying speech after the shooting Blake Lively vs. Justin Baldoni trial heats up — Taylor Swift to be deposed Hollywood and legal fallout explained Rachel Kirkconnell responds to the new Bachelorette announcement Fan reactions and franchise buzz  

 Tout le monde connait le nom de Max Jacob, poète moderniste, romancier et peintre, mais assez rares sont ceux qui se font une idée précise de son existence bohême et inspirée. Mention légales : Vos données de connexion, dont votre adresse IP, sont traités par Radio Classique, responsable de traitement, sur la base de son intérêt légitime, par l'intermédiaire de son sous-traitant Ausha, à des fins de réalisation de statistiques agréées et de lutte contre la fraude. Ces données sont supprimées en temps réel pour la finalité statistique et sous cinq mois à compter de la collecte à des fins de lutte contre la fraude. Pour plus d'informations sur les traitements réalisés par Radio Classique et exercer vos droits, consultez notre Politique de confidentialité.Hébergé par Ausha. Visitez ausha.co/politique-de-confidentialite pour plus d'informations.

This week's roundup spotlights four brand-new deposition rulings from across the country. Two address when plaintiffs may appear remotely—what courts require, what constitutes good cause, and the practical showings that move the needle. The other two confront a quiet but consequential trial hazard: deposition testimony that's read or played for the jury yet never placed into the record. (Many reporters pause their keyboards during read-ins, assuming the material is already transcribed—an easy oversight that can derail an appeal if the missing testimony is essential.) Join us for a concise tour of the standards, the pitfalls, and the simple steps to protect your record before it's too late. It's another critical episode from the country's leading expert on depositions. Citations and parentheticals to every case discussed appear in our show notes. Have a great week!SHOW NOTESNorth Carolina v. Johnson, No. COA24-451, 2025 WL 2408913 (N.C. Ct. App. Aug. 20, 2025) (court could not consider arguments in favor of reversal that were based on videotaped testimony played at trial but not placed into the trial record)G.W. Aru LLC, et al. v. W.R. Grace & Co. No. CV JKB-22-2636, 2025 WL 2402194 (D. Md. Aug. 19, 2025) (court ordered parties to transcript deposition excerpts played at trial, and then file those excerpts by stipulation, where they had not been entered into the docket)Shumaker v. Alarsi, et al., No. 1:23-CV-4-SA-DAS, 2025 WL 2418386 (N.D. Miss. Aug. 20, 2025) (rejecting motion for protective order, to allow plaintiffs to avoid 900-mile trip for in-person deposition, where the motion lacked any meaningful detail showing good cause for such an order)Shah v. Fortive Corporation, et al., Case No. 1:22-cv-312 (S.D. Ohio Aug. 21, 2025) (rejecting plaintiff's request to appear remotely where travel to the forum of the litigation would require "40,000 miles of flight over 48 hours"; plaintiff failed to show distinct hardship or expense)

Explore the importance of building confidence in clients for depositions in this episode of Trial Lawyer Prep, hosted by Elizabeth Larrick.   Learn the difference between confident witnesses and ego-driven witnesses, and discover practical strategies for instilling confidence in clients ahead of their depositions.   Elizabeth emphasizes using clients' words, co-creating preparation materials with them, and offering positive feedback. The goal is to help clients believe in their stories and communicate them effectively under questioning.   We also look at the importance of role play and testing, to ensure clients are truly prepared for their testimonies. In this episode, you will learn about: Understanding Confidence vs. Ego in Testimony Building Confidence: Using Client's Own Words Co-Creating Documents for Confidence The Importance of Positive Feedback and Encouragement Role Play: Test Your Client's Confidence   Follow and Review: We'd love for you to follow us if you haven't yet. Click that purple '+' in the top right corner of your Apple Podcasts app. We'd love it even more if you could drop a review or 5-star rating over on Apple Podcasts. Simply select “Ratings and Reviews” and “Write a Review” then a quick line with your favorite part of the episode. It only takes a second and it helps spread the word about the podcast.   Supporting Resources: You can watch this episode on my YouTube Channel: @ElizabethLarrick Check out the latest ways to re-wire your brain for better deposition prep in Episode 143. Book a free call with Elizabeth to pick her brain about deposition prep: https://calendly.com/elizabethlarrick Don't want to miss an episode? Join the Trial Lawyer Prep Newsletter for resources, tips and episodes by going here:  www.larricklawfirm.com/connect

Your client has a story to tell, but how they tell it may determine whether or not you win the case. Create the best possible impression by avoiding these pitfalls in your client's deposition.

Your client has a story to tell, but how they tell it may determine whether or not you win the case. Create the best possible impression by avoiding these pitfalls in your client's deposition. Learn more about your ad choices. Visit megaphone.fm/adchoices

Marcos do Val é alvo de operação da PF e terá que colocar tornozeleira eletrônica. BP anuncia descoberta de poço de petróleo no pré-sal da Bacia de Santos. Ministro de extrema direita de Israel gera crise após rezar em templo muçulmano e pedir 'conquista' de Gaza. Hamas divulga vídeo de refém israelense cavando a própria cova: 'Isso não é ficção, isso é real'. Funcionário da Voepass relata 'remorso desgraçado' por não ter registrado por escrito falha; ouça áudio.

Anne-Laure et moi avons vécu une expérience complètement inattendue et très rafraîchissante à Montmartre. Nous étions au Chat noir, version 2025. A la Halle Saint-PIerre se tient une fois par mois une "scène de poésie ouverte". Pourquoi ne pas aller y faire un tour lors de votre prochain passage à Paris? Ou bien, pourquoi ne pas aller y lire un poème que vous aimez. Bienvenue chez vous, au Chat noir.  www.onethinginafrenchday.com  

VLOG July 9 US v. Sean Combs sentencing Oct 3, offense conduct filing due July 11 https://matthewrussellleeicp.substack.com/p/exclusiveextra-diddy-alternate-juror Doe v Combs, unmasking: https://www.patreon.com/posts/diddy-dockets-by-133736855 Desiree Perez of Roc Nation to be deposed;@UN_Spokesperson Dujarric goes dark: https://www.innercitypress.com/ungate1dujarricicp070825.html

V 102. epizóde Vertiga sa povenujeme 78. ročníku festivalu v Cannes, predstavíme si najočakávanejšie filmy z hlavnej súťaže, ale prezradíme aj našich obľúbených víťazov Zlatej palmy za ostatné roky a možno aj desaťročia. Skočíme aj do kín, ktoré hrajú reboot Nezvratného osudu, ale aj ocenenú indickú drámu z minulého ročníka festivalu v Cannes – Záblesky nádeje. Zo streamov sme vybrali seriálové netflixoviny - Bad Boy a Štyri ročné obdobia. Ale nevynecháme ani kulinárske Babičky, ponor do televízneho sveta Saturday Night, či gangsterské Dve tváre zločinu. A máme pre vás ešte jednu príjemnú správu, za ktorú ďakujeme hlavne vám. V súťaži Podcast roka 2025 sme opäť získali nomináciu v umeleckej kategórii Ateliér. Budeme veľmi radi, ak nám dáte svoj hlas na stránke podcastroka.sk. Vážime si vašu podporu. Zoznam filmov a seriálov z epizódy: Nezvratný osud: Pokrvné puto / Final Destination: Bloodlines Záblesky nádeje / All We Imagine as Light Štyri ročné obdobia / The Four Seasons (Netflix) Dve tváre zločinu / The Alto Knights (Prime Video) Saturday Night (Max) Bad Boy (Netflix) Babičky / Nonnas (Netflix) See omnystudio.com/listener for privacy information.

Depo İstanbul 6 Mayıs 12 Temmuz tarihleri arasında Waseem Ahmad Siddiqui'nin …Şimdi! (Evinizde kalabilir miyim?) isimli kişisel sergisine ev sahipliği yapıyor.  Waseem Ahmad Siddiqui Lahor doğumlu, İstanbul'da yaşıyor. İlgi alanları arasında yer değiştirme, mekansal hikâye anlatımı ve sınırlarla ilişkili otobiyografik metodolojiler yer alıyor.  Siddiqui, aynı zamanda Apaçık Radyo'nun kalıcılık ve geçicilik, içerme ve dışlama, kamusal ve özel, misafir ve ev sahibi gibi kavramlara mültecilik perspektifinden yaklaşan programı Hüsnükabul'ün programcılarından. Depo İstanbul'da Waseem'le buluşuyor ve …Şimdi! (Evinizde kalabilir miyim?) sergisiyle ilgili sohbet ediyoruz.

Šo interviju ar Kārli Bardeli ierakstījām šī gada februārī un bijām plānojuši to publicēt februāra beigās. Bet tad notika neiedomājamais. Liktenīgajā 24. februāra vakarā Kārli, Bored Of Borders kapteini, nogādāja slimnīcā, kur viņam tika veikta steidzama smadzeņu operācija, kam dažas nedēļas vēlāk sekoja diagnoze par smadzeņu audzēju.Kārlis ir sešu Ginesa rekordu ieguvējs. Trijos no tiem viņu neviens nevarēs pārspēt un tie vienmēr piederēs mūsu Kārlim.Šobrīd, kad Kārlis atgūst savu spēju runāt, šī intervija ir iespēja dzirdēt par Kārļa episko astoņu gadu ceļojumu apkārt pasaulei. Par airēšanu pāri Indijas okeānam un viņa dramatiskajām dienām bīstamās Somālijas tuvumā, kā arī par piedzīvojuma noslēguma posmu, braucot 5000 km ar velosipēdu pāri Āfrikai.Saruna ir par optimismu kā dzīves svarīgāko īpašību, spēju transformēt neveiksmes enerģijā, par negaidīti atrastu mīlestību un simbolisko atgriešanos pasaules apceļošanas sākumpunktā. Aicinu tevi pievienoties Kārļa atbalstam ar ziedojumu, kas ģimenei palīdzēs segt milzīgos medicīniskos izdevumus, lai Kārlis var saņemt viņam nepieciešamo ārstēšanu:Bankas konts: LV05HABA0551024115873Saņēmējs: Kārlis BardelisMaksājuma mērķis: Kārļa Bardeļa rehabilitācijaiBored of Borders komanda un Kārlis saka lielu paldies filmas ģenerālsponsoram DEPO - par draudzību kopš 2017.gada un atbalstu filmai "AIZSNIEGT DZELMI. Vienatnē pāri klusajam okeānam".Informāciju un saites, kas pieminētas šajā intervijā, atradīsi 227. sarunas lapā.SARUNAS PIETURPUNKTI:02:11 Ievads - saruna ar Kārļa mammu par Kārļa veselībs stāvokli pēc smadzeņu operācijas11:19 Ceļojuma statistika - kā 8 gadu garumā Kārlis pieveica ceļu apkārt pasaulei13:07 Ekspedīcijas posmi piedzīvojumam, kas sākās un noslēdzās Namībijā16:31 Indijas okeāns un Malaizija - 172 dienas pāri Indijas okeānam20:07 Kā laiva palika “gūstā”, kas izjauca plānus24:15 Atgriezties Somālijā pēc neizdošanās un uzdrošināties vēlreiz pamatīgi riskēt27:04 Kaut vai norāpot, bet lai “visi papīri tīri”30:22 Loģistikas problēmu izjauktie plāni un pazaudēts vesels gads - kā ar to sadzīvot32:58 Kārļa pieeja, kā tikt galā ar vilšanās sajūtu, ja ceļā ir milzu šķēršļi35:11 Kā Kārlis savas dusmas transformē enerģijā40:38 Negaidīti, bet īstajā brīdī satikta mīlestība46:31 Pasiekstes vējdzirnavas, kur rīkot neaizmirstamus notikumus. Vairāk informācijas: vejdzirnavas.lv47:40 Kā paskaidrot tuviniekiem par došanos atpakaļ uz bīstamo Somāliju50:02 Kāpēc optimisms ir dzīves svarīgākā īpašība52:21 Kārļa ģimenes atbalsts viņa ceļotāja dzīvē57:46 Kārļa “maģiskais birojs”, kur iegūti piedzīvojuma ceļabiedri1:02:46 Sarunu māksla, lai veiksmīgi vienotos ar vietējiem bīstamās situācijās1:05:11 Nakts piedzīvojums ar somāliešu zvejniekiem un naudas maisu1:14:35 Dramatiskās 3 diennaktis atpakaļ uz krasta pusi1:18:04 Āfrikas šķērsošana pa sauszemi: 5000 km vienatnē ar divriteni 60 dienās1:22:04 Āfrikas pieturpunkti - karstums, satiksme un robežas šķērsošana1:26:15 Ar velosipēdu braukt garām žirafēm un ziloņiem01:28:37 Pārdomas un maiņa attieksmē pret tuksnesi01:33:15 Power-Up SPACE ir vieta, kur īstenot savus radošos projektus: powerupspace.eu.01:34:15 Finišs ar draugiem01:48:57 Notikums ar skolas garderobistēm, kas Kārli iedvesmoja doties piedzīvojumos01:54:55 Kā un kāpēc Kārlis dalās ar savu pieredzi uzņēmumos01:59:23 Kāpēc godīgums un patiesums ir svarīgākais runātāja ierocis

VLOG April 11 Sarah Palin v. NYT round II; ICE deposed by Yunseo Chung? DOJ crypto memo in Do Kwon https://www.amazon.com/dp/B0DV2X962LEisenberg, Mashinsky. Nadine Menendez end game https://www.amazon.com/dp/B0D9M216WPUN DSS buy-out scoop: https://www.innercitypress.com/ungate2latecutsasbanpressicp041025.html

Дорогие друзья. Сегодня Вас ждёт горячий микс, состоящий из хитов российской и зарубежной музыкальной сцены в ремиксах, Edit'ах и Blend'ах в стиле Drum & Bass. TRACKLIST: 01. ЮЛИЯ САВИЧЕВА - ПРИВЕТ (Sergei Ryazanoff D'n'B Remix) 02. Аня Кониченко - Улетаю cover (YAKUDZO Remix) 03. My Desire - Denis First (Alex Rudy DnB Remix) 04. Alok - Squid Game [MS MUSIC DNB REMIX] 05. A.M.C - Run! (Loken Edit) 06. Dj Philchansky feat. L'One - Благословляю на рейв (DIQÓ BLEND) 07. DJ Smash x Sub Focus - Я Волна (Ivan ART Mash) 08. The Ketchup Song - Aserejé (MARSHALLZ BEATS Mashup REMIX) 09. Kseniya GL - Я просто живу тобой (PashaRav REMIX) 10. Betsy, Мария Янковская - Сигма Бой (E-VitaN Remix) 11. Agressor Bunx - MS13 (FA edit) 12. Avril Lavigne - Hello Heartache (Rust Light bootleg) 13. Stim Axel - Ночи без тебя (Bad Songs Project Remix) 14. Макsим x Andromedik - Отпускаю (Ivan ART Mash) 15. Solardo - Testify (Jaworski Bootleg) 15. DJ Smash - Волна (Black Rook Remix) 16. Mayvery - Это электробус (Vol'demar DnB Remix) 17. Многоточие - Щемит В Душе Тоска (M&Dance Remix) 18. DVE ASTI x NILETTO x Sub Focus - Царица в худи (Ivan ART Mash) 19. NATALIYA – LOVE LOVE (TGS Remix) 20. Кишлак x Amplify, Matt Neux - Самый лучший день (Anton Oripov Mashup) 21. Mahmoud El Leithy - Satalana (Dmitriy Decoy bootleg) 22. МЭЙБИ БЭЙБИ & ДОРА & Vluarr & Arcando feat. Felix Samuel - БАРБИСАЙЗ (ONEGINЪ BLEND) 23. Skrillex & Bibi Bourelly - Don't get too close (GIVEMEACORN Remix) 24. Макс Корж - Малый повзрослел (JONVS Remix) 25. kavabanga & Depo & kolibri – Амфетамин (DenisKa Firsov Remix) 26. BORIS REDWALL, LOVV66 - ESLI NE TI (Azago Edit) 27. ROBIN SCHULZ - One By One (DJ Zvonkoff Remix) 28. Subbota - Манго (Michael Kruzh Remix) 29. Skrillex feat Sirah - Kyoto (Brutix Bootleg) 30. Sabrina Carpenter - Espresso (SW0P Remix) ▶ PromoDJ: promodj.com/aeroritmix ▶ VK: vk.com/public204888851 ▶ Telegram-канал: aeroritmixmuzik t.me/aeroritmixmuzik Подписывайтесь на мой подкаст (Subscribe to My Podcast): ● Apple Podcasts - podcasts.apple.com/ru/podcast/… ● Pocket Casts - pca.st/drpc1gfj Слушайте и наслаждайтесь! Listen & Enjoy! From Russia with Love!

Avec Catherine Coquio, Nisrine Al Zahre, Abigail Lang, Jean-Pierre Lefebvre, Philippe Huneman, Guido Mazzoni & Tetyana Ogarkova Et, pour la revue Po&sie, Chawki Abdelamir, Jean-Patrice Courtois, Claude Mouchard, Claire Paulian, Martin Rueff & Theombogü Dans le présent meurtri des démocraties qu'attendre des poèmes et de la poésie ? Au chapitre 9 de De la tyrannie, vingt leçons du XXe siècle, Timothy Snyder écrit qu'il faut, pour lutter contre la tyrannie, « prendre soin de notre langage » et « éviter les formules que tout le monde prononce ». C'est bien cela : l'art du langage n'est pas un art de vivre qui combattrait les cyniques puissances de mort qui se lèvent partout, mais il peut, par le soin qu'il accorde aux mots des vivants tourner l'attention vers leurs conditions d'existence, vers leur présent, et, parfois, vers leurs espoirs. Depuis sa création Po&sie ne cesse de mettre la poésie en relation avec la politique, avec la démocratie et aujourd'hui, alors que celle-ci semble si gravement menacée par les tentations illibérales de tant de gouvernants, par l'irresponsabilité et la compromission cynique, par l'accélération des violences et des guerres, la revue tient à faire entendre quelques voix pour défendre ce qui, plus que jamais, reste à défendre. Cette séance ne vise en rien à faire la carte de l'exhaustivité des périls. Elle veut contribuer à diriger notre regard vers des situations, des configurations politiques, des menaces. Rencontre proposée par la revue Po&sie. La revue Po&sie est éditée aux éditions Belin.

Avec Katerina Apostolopoulou, Nawel Ben Kraïem, Aurélien Dony, Bruno Doucey, Aurélia Lassaque & Murielle Szac Accompagnés par le musicien Nassim Kouti Vivante-Vibrante, Planétaire, Babel, Ensemble, Coloré, Résistance, Découverte, Intime, Solaire, Chant, Combats, Désobéissance, Transmission, Hospitalité, Fraternité-Sororité : les voici les quinze mots par lesquels nous entendons fêter le Printemps des Poètes 2025 et le quinzième anniversaire de la maison d'édition Bruno Doucey. 15 ans ! C'est le temps de l'amour, le temps des copains et de l'aventure… Oui, mais le 15 est aussi un numéro d'appel d'urgence, celui du SAMU, acronyme que nous déclinons ainsi : Service d'Aide aux Mots Universels, ou pour les moins optimistes d'entre nous, Sauvez Au Moins l'Universel ! SAMU social oblige, 115 poètes constituent l'armée de libération que nous levons cette année pour faire front aux menaces de notre temps. Parce que la poésie élargit le monde de son sourire. Dans le cadre du Printemps des Poètes. À lire – 15, Service d'Aide aux Mots Universels, anthologie établie par Bruno Doucey et Ariane Lefauconnier, éd. Bruno Doucey, 2025.

durée : 00:53:17 - Certains l'aiment Fip - Tout comme le poème, le film est voué au mouvement, au rythme. D'ailleurs souvent il s'en inspire pour se détacher du réel. Plongeons dans les musiques d'"Orphée" de Cocteau, "Les enfants du paradis" de Carné, "Bright Star" de Campion, "Pierrot le fou" de Godard ...

durée : 00:47:10 - La 20e heure - par : Eva Bester - Chantre d'une pensée du divers et de la relation, Patrick Chamoiseau vient de publier "Que peut Littérature quand elle ne peut ?" au Seuil. Lui qui se disait "guerrier de l'imaginaire" s'interroge encore sur les pouvoirs de la création artistique face à l'ordre néo-libéral du monde tel qu'il va. - invités : Patrick Chamoiseau - Patrick Chamoiseau : Écrivain - réalisé par : Lola COSTANTINI

durée : 00:47:10 - La 20e heure - par : Eva Bester - Chantre d'une pensée du divers et de la relation, Patrick Chamoiseau vient de publier "Que peut Littérature quand elle ne peut ?" au Seuil. Lui qui se disait "guerrier de l'imaginaire" s'interroge encore sur les pouvoirs de la création artistique face à l'ordre néo-libéral du monde tel qu'il va.

durée : 00:15:02 - Les Nuits de France Culture - par : Philippe Garbit - Clair de nuit - Tentatives premières - réalisation : Virginie Mourthé

Is everyone a leader? Rejecting anonymity. Father Nathan Cromly from the Saint John Leadership Institute joins Trending with Timmerie. (5:01) What is the difference between Christian leadership and worldly leadership? (23:33) Depo provera lawsuit. (36:51) Resources mentioned : St. John Institute https://www.saintjohninstitute.org/ Lawsuits amassing over Depo-Provera’s link to brain tumors https://naturalwomanhood.org/lawsuits-amassing-over-depo-proveras-link-to-brain-tumors/

Oui, le livre Cent mille milliards de poèmes de Raymond Queneau contient réellement 100 000 milliards de poèmes. Ce nombre impressionnant est rendu possible par une structure astucieuse et mathématique, caractéristique des travaux de Queneau, membre fondateur de l'Oulipo (Ouvroir de Littérature Potentielle). Le concept du livrePublié en 1961, ce livre n'est pas un recueil de poèmes traditionnels. Il se présente comme un objet littéraire expérimental composé de dix sonnets, chacun ayant quatorze vers. La particularité réside dans le fait que chaque vers de chaque sonnet peut être combiné avec n'importe quel autre vers occupant la même position dans les neuf autres sonnets. Ainsi, les lecteurs peuvent créer leurs propres sonnets en choisissant un vers à chaque ligne. Le calcul mathématiqueChaque sonnet comporte 14 vers. Étant donné que chaque position dans le sonnet (première ligne, deuxième ligne, etc.) offre 10 choix possibles, le nombre total de combinaisons possibles est 10^14. Expérience de lectureCe nombre dépasse largement ce qu'un être humain peut lire dans une vie. Si une personne lisait un poème par minute, sans pause, il lui faudrait environ 190 millions d'années pour parcourir toutes les combinaisons possibles. Cela fait du livre une œuvre pratiquement infinie dans sa potentialité, un véritable "livre combinatoire". Signification littéraireL'idée centrale de Queneau est de démontrer l'immense potentiel créatif contenu dans des structures fixes. Bien que les poèmes soient régis par des règles strictes (le format du sonnet), la multiplicité des combinaisons offre une liberté d'interprétation et de création infinie. Cela illustre une idée chère à l'Oulipo : produire des œuvres littéraires en jouant avec des contraintes formelles. ConclusionCent mille milliards de poèmes est à la fois un exploit mathématique et une expérimentation littéraire. Oui, le livre contient réellement 100 000 milliards de poèmes, non pas en tant que textes écrits sur papier, mais en tant que potentialités combinatoires offertes au lecteur, faisant de lui un co-créateur de l'œuvre. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Today's roundup of new deposition-related cases focuses on four rulings. One offers a great strategy to exclude hostile deponents' deposition testimony, where they answer your opponents' questions but refuse to let you fully and fairly cross-examine them. A second touches on the age-old question of whether "Form!" or "Objection!" is enough or whether you must articulate the specific evidentiary basis. The third offers an idea for administering a slightly modified oath to immature deponents who might not understand the standard oath. The fourth looks at a novel approach one party took in noticing an individual witness with an attached, lengthy 30(b)(6) list of topics relating to matters that seemed better suited for a corporate representative.Thanks for listening! And be sure to check out the book upon which this podcast is based, 10,000 Depositions Later: The Premier Litigation Guide for Superior Deposition Practice. Available on Amazon and almost everywhere else books are sold. Now in it's fourth edition at 600 pages. It's a career-saving resource.SHOW NOTESPerrot v. Kelly, et al., Case No. 18-cv-10147, 2023 WL 11873009 (D. Mass. October 27, 2003) (reserving right to exclude deponent's testimony if witness continued to thwart plaintiff's opportunity to fully and fairly examine her, under FRE 804 relating to witness "unavailability"; court appears to equate refusal to give testimony with unavailability)B.P., et al. v. City of Johnson City, et al., No. 2:23-cv-71-TRM-JEM, 2024 WL 3461408 (E. D. Tenn. July 18, 2024) (refusing to limit lawyer to word "Objection" during depositions, and stating that lawyers have obligation to state the specific basis for the objection and not limit it to "objection" or "form" alone; further declining to sanction lawyer for longer narrative objections about incomplete documents because they were not intended to coach witness as to a particular answer)People v. Lopez, 550 P.3d 731 (Ct. App. Colo 2024) (affirming conviction of criminal defendant over objection that trial judge conducted modified administration of oath to 10-year old witness; finding that modified oath is appropriate for an immature witness who may not understand standard oath)Jacobs, et al. v. Journal Publishing Company, et al., Case No. 21-690-MW/SCY, 2024 WL 3401048 (D. N. M. July 12, 2024) (rejecting plaintiffs' effort to depose individual by serving FRCP 30(b)(6)-style deposition notice with lengthy attached topic list)See, 30(b)(6)-style Deposition Notice Served on Individual, PACER CM/ECF Doc. No. 135-1 (showing notice with attached topic list and list of documents to be brought by individual deponent) Jacobs, et al. v. Journal Publishing Company, et al., Case No. 21-690-MW/SCY, 2024 WL 3401048 (D. N. M. July 12, 2024)