Podcasts about Vali

Je spoluautorem knihy Hypernormal: Jak si zachovat suverenitu v éře umělé inteligence. AI přepisuje pravidla a otázkou není, jak to zastavit, ale jak v tomto novém normálu neztratit sám sebe. „Měli bychom k umělé inteligenci přistupovat jako ke stroji,“ konstatuje ve Vizitce.

İçişleri Bakanı Mustafa Çiftçi'nin; “İçten içe büyüttüğüm niyazım şuydu: Rabbim bana bir gün de olsa Kudüs Valiliğini nasip et” mesajı bu coğrafyanın ülküsünü, kalbindeki hasreti, akli ve vicdani hedefi yansıtır.

Žáci a studenti v projektu Příběhy našich sousedů objevují pro Paměť národa poslední žijící svědky druhé světové války. Podařilo se jim zdokumentovat například pozoruhodný příběh sudetského Němce ze Šumavy. Jindřich Essl, narozen 1939 na Šumavě v sudetoněmecké rodině, vyprávěl žákům o svém tatínkovi, který musel narukovat do wehrmachtu. Na frontě padl do sovětského zajetí. Jeho bratr byl za války donucen nastoupit na nucené práce.

Ryan Alford sits down with Ismail Vali for a conversation that turns online gambling into a much bigger business and policy discussion. Ismail explains why he believes illegal and unregulated operators still dominate huge parts of the online gambling market, why legal operators have struggled to capture the economics people assumed they would, and how regulators remain behind the technology that changed the game years ago. He also lays out how offshore gambling, illegal streaming, and prediction-style products are creating a broader ecosystem that is harder to regulate and easier for consumers to stumble into than most people realize. Ryan brings the entrepreneur and free-market lens, pushing on consumer choice, overregulation, and where the line should actually be drawn. That back-and-forth makes this episode especially strong for listeners interested in business, policy, regulation, digital markets, and the unintended consequences of pretending a fast-growing market does not exist. Topics Covered The economics of illegal online gambling Why legal gaming markets are still underperforming expectations The role of offshore operators in value extraction Why some states still have no legal online gambling How prediction markets and other gray-area products fit in Why Ismail says the market is already here whether lawmakers accept it or not Consumer choice versus consumer protection Ryan Alford and Ismail Vali on what sensible regulation could look like Ryan Alford Website: https://www.ryanisright.com/ Instagram: https://www.instagram.com/ryanalford/ Ismail Vali / Gaming Compliance International Website: https://gamingcompliance.com/ Linkedin: https://www.linkedin.com/in/ismailvali/ GCI Linkedin: https://www.linkedin.com/company/gaming-compliance-international

Why are hundreds of thousands of people once again walking the ancient pilgrimage routes of Europe?In this episode, we explore the remarkable revival of the Camino de Santiago and other medieval pilgrimage paths — journeys once central to European spiritual life that are now attracting modern seekers searching for meaning, healing, silence, and transformation.From the dangerous pilgrimages of the Middle Ages to the modern Camino revival sparked by Father Elías Valiña's famous yellow arrows, this episode examines why so many people today feel drawn toward experiential spirituality beyond institutional religion alone.We also explore how pilgrimage changes people emotionally, spiritually, and psychologically — and why few return home unchanged.#CaminoDeSantiago #Pilgrimage #Spirituality #ExperientialSpirituality #MeaningOfLife #PersonalGrowth #WalkingMeditation #Mysticism #InnerTransformation #Podcast #Mindfulness #MedievalHistory #SpiritualJourney #SelfDiscovery #SlowLivingUseful Information:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠www.reinogevers.com⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://reinodiary.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Books:⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Sages, Saints and Sinners⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Deep Walking for Body Mind and Soul⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Walking on Edge: A pilgrimage to Santiago⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

Bez mobilu, s jediným eurem na den a odkázaní na pomoc cizích lidí. Dvojice známá jako Toužimáci – Ivana Mikulová a Jiří Horník - přiblížila zákulisí drsné reality show napříč Kambodžou, Laosem a Thajskem. Přiznali psychické vyčerpání, strach i momenty, na které nikdy nezapomenou.

Obvinění aktéři úplatkářské kauzy si jezdili pro peníze z nelegálních sázek do Vídně. Nejprve sami, později posílali najaté kurýry. Kriminalistům to nevědomky prozradil fotbalový agent Daniel Černaj. „Bylo to v prosinci 2024, kdy se Černaj sešel s Kamilem Javůrkem, což je bývalý detektiv z NCOZ, který pracuje ve Fotbalové asociaci a má za úkol odhalovat právě zmanipulované zápasy,“ přibližuje investigativní reportér Artur Janoušek. Poslechněte si rozhovor.

Martin Hanus, Jozef Majchrák a Marek Vagovič diskutujú o tom, či Robert Fico smeruje k porážke, prečo je kauza matky pre Michala Šimečku problém a čo musí spraviť opozícia, aby mala šancu na úspech. Táto relácia vznikla vďaka našim podporovateľom. Pridajte sa k nim, prosím, teraz aj vy na: https://podpora.postoj.sk/potrebujeme-vas?suma=10&referral_campaign=reakcia_simecka_maj_26&referral_source=youtube. Ďakujeme.

Obvinění aktéři úplatkářské kauzy si jezdili pro peníze z nelegálních sázek do Vídně. Nejprve sami, později posílali najaté kurýry. Kriminalistům to nevědomky prozradil fotbalový agent Daniel Černaj. „Bylo to v prosinci 2024, kdy se Černaj sešel s Kamilem Javůrkem, což je bývalý detektiv z NCOZ, který pracuje ve Fotbalové asociaci a má za úkol odhalovat právě zmanipulované zápasy,“ přibližuje investigativní reportér Artur Janoušek. Poslechněte si rozhovor.Všechny díly podcastu Seriál Radiožurnálu můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

durée : 00:24:06 Vous aimez ce podcast ? Pour écouter tous les épisodes sans limite, rendez-vous sur Radio France

durée : 00:24:17 Vous aimez ce podcast ? Pour écouter tous les épisodes sans limite, rendez-vous sur Radio France

Prístup štátu v Česku a Slovensku v čase krízy sa výrazne líšil. My sme sa snažili ochrániť spotrebu, Česi znížili spotrebu. Za našimi najbližšími susedmi dlhodobo zaostávame v investíciách. Do tých najviac produktívnych oblastí investujeme najmenej v Európe, upozorňuje v podcaste Aktuality Nahlas ekonóm Martin Hudcovský z Katedry hospodárskej politiky na Národohospodárskej fakulte Ekonomickej univerzity.Spolu s kolegom Karolom Morvayom publikovali provokatívnu analýzu, kde ukazujú, že na jedno investované euro na Slovensku pripadajú až štyri eurá spotreby. Aj toto je zdroj investičného dlhu.„Máme asi tisícku firiem, ktoré sú superhviezdami v produktivite. Menšie a stredne veľké podniky sú však menej produktívne. V Česku tento problém nie je taký vypuklý,“ hovorí Hudcovský. Dodáva, že tento trend sa za ostatných 20 rokov ešte zhoršil.Hudcovský s kolegami z univerzity pomáhal aj pri príprave niektorých prorastových opatrení, ktorými sa vláda bude pokúšať oživiť ekonomiku. „Tieto opatrenia nie sú zázračný liek,“ upozorňuje.Pripravil Vladimír Amrich a na podcaste spolupracovali aj Sára Smatanová a Štefan Kurilla.

Prístup štátu v Česku a Slovensku v čase krízy sa výrazne líšil. My sme sa snažili ochrániť spotrebu, Česi znížili spotrebu. Za našimi najbližšími susedmi dlhodobo zaostávame v investíciách. Do tých najviac produktívnych oblastí investujeme najmenej v Európe, upozorňuje v podcaste Aktuality Nahlas ekonóm Martin Hudcovský z Katedry hospodárskej politiky na Národohospodárskej fakulte Ekonomickej univerzity.Spolu s kolegom Karolom Morvayom publikovali provokatívnu analýzu, kde ukazujú, že na jedno investované euro na Slovensku pripadajú až štyri eurá spotreby. Aj toto je zdroj investičného dlhu.„Máme asi tisícku firiem, ktoré sú superhviezdami v produktivite. Menšie a stredne veľké podniky sú však menej produktívne. V Česku tento problém nie je taký vypuklý,“ hovorí Hudcovský. Dodáva, že tento trend sa za ostatných 20 rokov ešte zhoršil.Hudcovský s kolegami z univerzity pomáhal aj pri príprave niektorých prorastových opatrení, ktorými sa vláda bude pokúšať oživiť ekonomiku. „Tieto opatrenia nie sú zázračný liek,“ upozorňuje.Pripravil Vladimír Amrich a na podcaste spolupracovali aj Sára Smatanová a Štefan Kurilla.

Burrull salta en defensa de los árbitros: "Florentino, ya valió de juntar las palabras colegiados y robar"See omnystudio.com/listener for privacy information.

Dnes sa začína súdny proces v kauze Očistec. Ide o kauzu obrovských rozmerov, kde sú pre trestné činy založenia zločineckej skupiny, korupcie či zneužívania právomoci verejného činiteľa obžalovaní aj podpredseda parlamentu za Smer Tibor Gašpar, jeho príbuzný nitriansky oligarcha Norbert Bödör, bývalý špeciálny prokurátor Dušan Kováčik, či bývalé vedenie NAKA za tretej vlády Roberta Fica.Ako vyzeralo vyšetrovanie o aké výpovede a dôkazy sú spísané v 181 stranovej obžalobe? Na čom stavia svoju obranu obhajoba? Ako s tým súvisia aktuálne vyšetrovania Úradu inšpekčnej služby voči bývalým vyšetrovateľom? A ako môže celý súdny proces ovplyvniť najnovšia novela trestného zákona ministra Suska? Braňo Závodský sa rozprával s Xéniou Makarovou z Nadácie Zastavme korupciu.

Nikol s moderátorom Mišom Totkom prebrala všetko od jej príchodu, ktorý začal DJ setom, až po vypadnutie, ktoré neprebehlo na ceremoniáli, ale na rande po vášnivej debate s Adriánom o jeho uzavretosti a správaní voči nej.

💬 Mándame un Mensaje o un Audio insultándome o contándome tu vida al WhatsApp 644 39 32 31 🍺 Venga Valientes, ¿Quien quiera invitarnos a unas Cañas con Bravas? Bizum al 644 39 32 31 🧦 ¡CALCETINES GRATIS, HOSTIA! Usa el código “SINPELOS” en PAMPLING.COM y te llevas un par de calcetines por la Cara 😈 Hazte MECENAS por 2€/mes y desbloquea los capítulos PROHIBIDOS y exclusivos 📧 ¡NO TE CORTES NI UN PELO! Escríbenos a sinpelosenlosbits@gmail.com contando tus aventuras desastrosas, tus teorías locas o simplemente para mandarnos a la mierda (aceptamos todo) 📬 Entra YA al Grupo de Telegram antes de que nos lo cierre Putin, ¡CORRE! https://t.me/joinchat/RG9ERxvMGl445Ri1FqgMNg ❌ Prohibido reproducir fuera de iVoox… o sea, que si lo pillan en YouTube me crujen vivo. Pero si lo mandas por WhatsApp a tu grupo de locos, yo no he visto nada Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

💬 Mándame un Mensaje o un Audio insultándome o contándome tu vida al WhatsApp 644 39 32 31 🍺 Venga Valientes, ¿Quien quiera invitarnos a unas Cañas con Bravas? Bizum al 644 39 32 31 🧦 ¡CALCETINES GRATIS, HOSTIA! Usa el código “SINPELOS” en PAMPLING.COM y te llevas un par de calcetines por la Cara 😈 Hazte MECENAS por 2€/mes y desbloquea los capítulos PROHIBIDOS y exclusivos 📧 ¡NO TE CORTES NI UN PELO! Escríbenos a sinpelosenlosbits@gmail.com contando tus aventuras desastrosas, tus teorías locas o simplemente para mandarnos a la mierda (aceptamos todo) 📬 Entra YA al Grupo de Telegram antes de que nos lo cierre Putin, ¡CORRE! https://t.me/joinchat/RG9ERxvMGl445Ri1FqgMNg ❌ Prohibido reproducir fuera de iVoox… o sea, que si lo pillan en YouTube me crujen vivo. Pero si lo mandas por WhatsApp a tu grupo de locos, yo no he visto nada Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

💬 Mándame un Mensaje o un Audio insultándome o contándome tu vida al WhatsApp 644 39 32 31 🍺 Venga Valientes, ¿Quien quiera invitarnos a unas Cañas con Bravas? Bizum al 644 39 32 31 🧦 ¡CALCETINES GRATIS, HOSTIA! Usa el código “SINPELOS” en PAMPLING.COM y te llevas un par de calcetines por la Cara 😈 Hazte MECENAS por 2€/mes y desbloquea los capítulos PROHIBIDOS y exclusivos 📧 ¡NO TE CORTES NI UN PELO! Escríbenos a sinpelosenlosbits@gmail.com contando tus aventuras desastrosas, tus teorías locas o simplemente para mandarnos a la mierda (aceptamos todo) 📬 Entra YA al Grupo de Telegram antes de que nos lo cierre Putin, ¡CORRE! https://t.me/joinchat/RG9ERxvMGl445Ri1FqgMNg ❌ Prohibido reproducir fuera de iVoox… o sea, que si lo pillan en YouTube me crujen vivo. Pero si lo mandas por WhatsApp a tu grupo de locos, yo no he visto nada Escucha el episodio completo en la app de iVoox, o descubre todo el catálogo de iVoox Originals

VYPLŇTE NÁŠ PODCASTOVÝ PRIESKUM: http://www.zabavavpodcastoch.sk/prieskum 152. epizóda Vertiga bude opäť bohatá na predstavenie noviniek z kín a online priestoru. V kinách na vás striehne Diabol nosí Pradu 2, ktorý sa snaží upozorniť nielen na outfit, ale aj na to, čo treba mať v hlave. Rovnako na vás čaká aj skvelý španielsky oceňovaný film Nedeľa či slovenský dokument Milota o umelkyni a fotografke Milote Havránkovej. Streamovacie platformy zastúpia seriály Napoly muž, Register trestov, animovaný Stranger Things, ale aj filmová žánrovka Apex. Zoznam filmov a seriálov z epizódy: 00:00 Úvod 00:53 Diabol nosí Pradu 2 / The Devil Wears Prada 2 13:01 Nedeľa / Los Domingos 19:50 Milota 23:04 Prípad 137 / Case 137 29:38 Apex (Netflix) 36:30 Napoly muž / Half Man (HBO Max) 40:14 Register trestov / Criminal Record 2 (Apple Tv+) 43:24 Stranger Things: Příběhy z pětaosmdesátého / Stranger Things: Tales from '85 (Netflix) 47:45 Záver _ Ak nám chcete napísať, ozvite sa na vertigo@sme.sk _ Ďakujeme, že počúvate podcast Vertigo a zaujímate sa o filmový svetSee omnystudio.com/listener for privacy information.

El mensaje de Gustavo Valiño, reflexiona sobre cómo la verdadera paz espiritual no es simplemente la ausencia de problemas o conflictos externos, sino una experiencia profunda que brota del vínculo con Dios.El predicador desarrolla tres pilares fundamentales sobre esta paz:+ La paz del perdón: Es el punto de partida. Basado en Romanos 5:1, explica que al ser justificados por la fe, obtenemos paz con Dios. Esto libera al creyente de la culpa y de las deudas del pasado, permitiendo una restauración plena, similar a la historia de la mujer que lavó los pies de Jesús (Lucas 7).+ La paz de la presencia: Jesús nos dejó un regalo que el mundo no puede dar: una paz que guarda el corazón y la mente en medio de las angustias. No significa que los problemas desaparezcan, sino que en medio de ellos, podemos aferrarnos a Dios para recibir descanso y protección (Filipenses 4).+ La paz de la esperanza: Se sostiene en la confianza sobre el futuro. Basado en Jeremías 29, Valiño destaca que Dios tiene pensamientos de paz y no de mal para darnos un porvenir. Esta esperanza permite mirar hacia adelante con serenidad, confiando en que Dios continúa escribiendo nuestra historia.El mensaje concluye con un llamado a abrir el corazón para recibir este regalo, recordándonos que el perdón quita la culpa, la presencia quita el temor y la esperanza quita el desánimo.https://www.buenasnuevas.org.arEscuchanos en Spotify:https://open.spotify.com/show/6zMtHdo7USfYVH1E3YZGeVSeguinos en Instagram:https://www.instagram.com/buenasnuevasba/Seguinos en Facebook:https://www.facebook.com/IBNoficial

Tesla konečně přiznala, že HW3 nezvládne plně autonomní FSD bez dohledu. Do toho se řeší další otázky kolem Robotaxi, Cybercabu, Optimuse i vlastních AI čipů. Jde o skutečný technologický posun, nebo jen další posunuté termíny a nenaplněné sliby?V tomhle videu rozebírám nejzajímavější momenty a proč to pro Teslu nemusí vypadat tak růžově, jak se prezentuje.

Gülistan Doku, 5 Ocak 2020'de Tunceli'de kayboldu. Munzur Üniversitesi öğrencisi olan Gülistan'ın durağa doğru yürürken çekilen son görüntüsünden bu yana 6 yıl geçti; cesedi hâlâ bulunamadı, hiçbir iddianame düzenlenmedi. Peki bu dosyada neler gizlendi? Gazeteci Selahattin Günday, Medyascope'un Gazeteci Bakışı programında Alişer Delek'e soruşturmanın bilinmeyen ayrıntılarını aktardı: Hastane kayıtlarının silinmesi, SIM kartın kaybolması, sosyal medya hesaplarına Ankara'dan yapılan erişim, kör noktalardaki kamera değişiklikleri ve dönemin Tunceli Valisi Tuncay Sonel'in olaya doğrudan müdahalesi... Ablası Aygül Doku'nun 6 yıllık inatçı mücadelesi, gizli tanık ifadeleri ve ABD'deki firari Umut Altaş'ın konuşmaları bu davayı nasıl yeniden alevlendirdi? Soruşturmada valinin oğlu mu, yoksa valinin kendisi mi asıl şüpheli? Tüm bu soruları gazeteci bakışıyla mercek altına alınıyor. Learn more about your ad choices. Visit megaphone.fm/adchoices

Why has healthcare resisted digital transformation longer than almost any other industry? In this episode of Med Tech Gurus, we're joined by Mariano García-Valiño, four-time entrepreneur, digital health innovator, and CEO of AXENYA—recently named one of the world's best digital health companies by Newsweek. Mariano has built, scaled, and exited billion-dollar healthcare companies by combining technology, data, and human-centered design to tackle chronic disease at scale. Mariano is also the author of Inedible, where he argues that modern healthcare is still built for acute illness, not the chronic conditions driving today's costs and outcomes. In this conversation, we explore why software alone isn't enough, how AI and continuous care models unlock real impact, and what it actually takes to scale health tech in complex, regulated markets. From leadership and entrepreneurship to AI-enabled care delivery, Mariano shares hard-earned lessons on building companies with both scale and purpose. If you care about digital health, healthcare transformation, or meaningful innovation, this is a conversation you won't want to miss.

Gülistan Doku soruşturmasında eski Tunceli Valisi Tuncay Sonel tutuklandı. ABD Başkanı Trump, İran anlaşmaya yönelik önerisini sunana kadar ateşkesi uzatma kararı aldığını duyurdu.Bu bölüm MUBI hakkında reklam içermektedir. Aposto okurlarına özel 30 günlük deneme üyeliği sunan MUBI'de Wong Kar Wai imzalı Blossoms Shanghai izleyiciyle buluşuyor. Ayrıntılı bilgiye buradan ulaşabilirsiniz.

Gülistan Doku soruşturmasında önemli gelişmeler yaşanırken, Adalet Bakanı Gürlek Rabia Naz ve Rojin Kabaiş dosyalarının da incelendiğini söyledi. Okullara saldırılarla ilgili çalışmalar da sürüyor. Gürlek şiddet suçlarında çocuklara verilecek cezaların artırılacağını ve ailelerin de sorumlu tutulabileceğini belirtti. İsrail ve Lübnan arasında geçici ateşkese varıldı, Hürmüz Boğazı açıldı. Haber yoğunluğunda kaybolmak istemeyenler için gündemin öne çıkan başlıklarını özetledik...   

Men don't cry

Este sermón explora cómo la fe en Jesús nos ayuda a volvernos a prueba de tormentas, capaces de enfrentar los desafíos de la vida con fortaleza y esperanza. Valiéndose de la historia de Jesús calmando la tormenta, anima a los oyentes a confiar en Dios, superar el miedo y avanzar hacia nuevos niveles de crecimiento. Destaca la importancia de dejar atrás las relaciones tóxicas, abrazar el cambio y apoyarse en Jesús como el cimiento firme en medio de las tormentas de la vida. El mensaje ofrece una guía práctica para la resiliencia espiritual, la sanación y la transformación, recordándonos que, si bien llegan diferentes tormentas, el mismo Jesús permanece fiel y poderoso. ---------- Bienvenido al Podcast de LifeHouse Church.
Nos alegra mucho que estés aquí. Ya sea que estés escuchando desde casa, en tu camino al trabajo, o en un momento tranquilo de tu día, creemos que Dios tiene algo personal y oportuno para ti en este mensaje. En LifeHouse, nuestro corazón es sencillo: guiar a las personas a Conocer a Dios, Crecer juntos y Compartir a todos y hacer una diferencia. A través de mensajes prácticos y centrados en el evangelio, queremos ayudarte a crecer en tu fe, experimentar una transformación real y vivir tu propósito en la vida diaria. Estos mensajes hablan de áreas reales de la vida como las relaciones, el matrimonio, la familia, el propósito, la salud emocional y el crecimiento espiritual — no importa en qué etapa de tu camino de fe te encuentres.

This episode dives into a powerful and often overlooked strategy for financial advisors: using targeted digital marketing to consistently attract high-net-worth clients. Through a real-world case study, you'll hear how a repeatable system using short-form video ads can generate meaningful conversations with qualified prospects every single week. The discussion highlights not only the marketing strategy itself, but also the importance of clarity in messaging, operational readiness, and long-term commitment to growth.Here's what you'll learn in this episode: How to turn a complex financial service into a clear, compelling marketing message that attracts the right clientsWhy focusing on one specific client pain point can outperform broad, generic messagingThe evolution from traditional marketing methods to scalable digital campaigns that actually convertWhat systems and processes must be in place to successfully handle and close high-quality inbound leadsThis conversation is a strong reminder that effective marketing is not about doing more, but about doing the right things consistently. When paired with the right infrastructure and mindset, digital marketing can become a scalable and predictable growth engine for advisory firms. Connect with Skyler: skyler@valiconsulting.comLearn more about Vali here: http://valiconsulting.com/Learn more about the Group Coaching & Mastermind HERE!Check out The First 100 Days Course: The Advisor's Blueprint for a Remarkable Client Experience HERE!Learn more about Asset-Map financial planning software HERE! Learn more about our sponsor Beemo Automation HERE!   Check out the Efficient Advisor YouTube Channel HERE!Connect with Libby on LinkedIn HERE!Successful businesses don't get built alone. You need community! You need collaboration! Join us in The Efficient Advisor Community on Facebook.

Happy Birthday, Resident Evil! Am 22. März ist das legendäre Horror-Franchise unglaubliche 30 Jahre alt geworden. Um das gebührend zu feiern, haben wir uns einer absoluten Mammutaufgabe gestellt: Die ultimative Resident Evil Tier List! Magdalena, Andi, Vali und Yvraldis ranken wirklich ALLES. Von den glorreichen Originalen über die genialen Remakes bis hin zu den wildesten Spin-offs und dem brandneuen Resident Evil 9: Requiem. Dabei fliegen auch ordentlich die Fetzen: Warum hasst Vali Resident Evil 6 so abgrundtief? Ist RE7 wirklich besser als Village? Und warum ist Re:Verse völlig unumstritten auf dem allerletzten Platz gelandet? Alle Links zum GameStar Podcast und unseren Werbepartnern: https://linktr.ee/gamestarpodcast

V období mccarthismu skončily ze dne na den kariéry stovek amerických umělců. Pete Seeger sice byl nějaký čas komunistou, život si ale zničit nenechal. Vzal banjo a hrál i na dětských táborech. Skončilo to mnoha cenami a nominací na Nobelovu cenu.Všechny díly podcastu Portréty můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

Pátrali po dívkách ve východní Evropě, objížděli česká i slovenská města, navazovali kontakty přes modelingové agentury a slibovali kariéru v modelingu. Část nově zveřejněné korespondence z Epstein Library ukazuje, že i Česká republika byla terčem zájmu lidí, kteří pro Jeffreyho Epsteina vyhledávali ženy. Text Barbory Šturmové čte Renata Klusáková.https://www.investigace.cz/v-lete-pujdu-obhlednout-male-vesnice-na-slovensku-a-v-cesku-lide-jeffreyho-epsteina-vyhledavali-divky-i-u-nas/

Sumate a la #ComunidadGUSIAN ingresando a ⁠gusian.ar⁠IAN LEE CRISIS EN VIDEO!Terminamos HUSH en un loop de balances, reflexiones, puteadas y plot twists.Valió la pena?OJO CON LOS ANUNCIOS DEL FINAL!Próxima lectura: Jenny Sparks #1 (Tom King)⭐⭐⭐⭐⭐⭐Ian Gutierrez - Gus Casals#IanleeCrisisSumate a la #ComunidadGUSIAN ingresando a gusian.ar

Saca la copa de cristal, échale cerveza y levántala alto porque es miércoles, y ustedes saben que llegó el oasis en medio de su semana: ¡llegaron los mach0rr0s! Esta semana estuvo con nosotros Melissa “@guzabra” Guzmán, quien sacó a pasear toda las testosterona que no tiene Vali. En este episodio hablamos de la pelea del novio de Gaby Nalgas y La GoLda, el extraño junte de Valerie y Eliezer, y del puño que le metieron a Santini. Yovín anda relax corriendo jetsko, regresan los ‘royal rumbles' en La Placita, arrestan a Almighty y le pedimos al gobierno que suelten a un inocente vendedor de frituras. Free Pastelillo, puñeta!

V případu kolem implantací srdečních defibrilátorů ve Fakultní nemocnici Olomouc padlo ministerské trestní oznámení. Redakce Seznam Zpráv už dříve popsala podezření, že někteří pacienti v této nemocnici dostali defibrilátory bezdůvodně, ale také že došlo k rozsáhlým úpravám dokumentace klinické studie. O co v kauze jde?Host: Jiří Pšenička - investigativní reportér Seznam ZprávČlánek a další informace najdete na webu Seznam ZprávySledujte nás na sociálních sítích X, Instagram, Threads nebo Bluesky. Náměty a připomínky nám můžete psát na e-mail zaminutusest@sz.cz

Mariano García-Valiño is a healthcare technology entrepreneur and author who has founded and led multiple companies at the intersection of healthcare, software, and data, most recently as Founder, Chief Engineer, and CEO of Axenya, a digital health platform recognized by Newsweek and Galen Growth among the world's leading health-tech innovators. He has driven the growth, expansion, and successful exits of several major firms, including Bausch + Lomb (approx. 9B USD sale in 2013), Grupo Biotoscana (IPO around 1B USD in 2017), and M8 Pharmaceuticals (approx. 250M USD sale in 2023), and has also invested in and advised other healthcare and pharmaceutical ventures across Latin America.​Earlier in his career, García-Valiño held senior roles in global organizations such as Advent, Warburg Pincus, Aqua Capital, Pfizer, Lilly, and McKinsey, gaining broad international experience across the United States, Latin America, and Europe. He is the author of “INEDIBLE: How to Build the Modern, Tech-Enabled, Healthcare Experience,” a book that became a #1 Amazon best seller and Hot New Release in the United States, where he examines why healthcare has lagged in digital transformation and outlines how technology can enable more intelligent, connected, and preventive care.​In parallel to his business career, he is an experimental art photographer whose abstract work, exploring hyperobjects, entropy, and inter-temporality, has been exhibited in contemporary galleries and is held in private and museum collections in Argentina, Uruguay, Brazil, Colombia, Spain, and the United States. García-Valiño holds an Engineering degree from the Universidad de Buenos Aires, a Photography PC from Cornell University, and an MBA from Harvard Business School, where he studied as a Fulbright Scholar.LinkedIN page: https://www.linkedin.com/in/mgarciavalino/Book: https://a.co/d/05gLJOHHPhotography: https://mgarciavalino.com/Company: https://axenya.com/Connect and tag me at:https://www.instagram.com/realangelabradford/You can subscribe to my YouTube Channel herehttps://www.youtube.com/channel/UCDU9L55higX03TQgq1IT_qQFeel free to leave a review on all major platforms to help get the word out and change more lives!

Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.

Libertópolis al medio día, martes 17-02-2026

Třeba Babylon na Domažlicku koncem minulého roku koupil kdysi vyhlášený hotel Praha, kam jezdili výletníci už za první republiky. Teď chystá jeho přestavbu na byty.

Los expertos de Fuera de Juego analizan lo sucedido en la definición del duelo entre Real Madrid y Benfica. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Your skin is screaming what your blood work is whispering. Dr. Shawana Vali transformed how I understand the visible signs of internal dysfunction, & it's not what the beauty industry wants you to hear. Those wrinkles, breakouts, & pigmentation issues? They're your body's warning system telling you about adrenal fatigue, hormone imbalances, & inflammatory cascades happening deep in your tissues. Ready to look 5 years younger by treating the root cause instead of chasing symptoms? CLICK HERE TO BECOME GARYS VIP!: ⁠⁠https://bit.ly/4ai0Xwg⁠⁠ Connect with Dr. Shawana Vali Website: ⁠⁠https://bit.ly/467cGNl⁠⁠  YT: ⁠⁠https://bit.ly/3NuM9TU⁠⁠  IG: ⁠⁠https://bit.ly/4a6SMV5⁠⁠  TT: ⁠⁠https://bit.ly/4quCzij⁠⁠  FB: ⁠⁠https://bit.ly/4jN5ICM⁠⁠  LI: ⁠⁠https://bit.ly/4pPtqj8⁠⁠  Thank you to our partners H2TABS: “ULTIMATE10” FOR 10% OFF: ⁠⁠https://bit.ly/4hMNdgg⁠⁠ BODYHEALTH: “ULTIMATE20” FOR 20% OFF: ⁠⁠http://bit.ly/4e5IjsV⁠⁠ BAJA GOLD: "ULTIMATE10" FOR 10% OFF: ⁠⁠https://bit.ly/3WSBqUa⁠⁠ SNOOZE: LET'S GET TO SLEEP!: ⁠⁠https://bit.ly/4pt1T6V⁠⁠ COLD LIFE: THE ULTIMATE HUMAN PLUNGE: ⁠⁠https://bit.ly/4eULUKp⁠⁠ WHOOP: JOIN AND GET 1 FREE MONTH!: ⁠⁠https://bit.ly/3VQ0nzW⁠⁠ AION: “ULTIMATE10” FOR 10% OFF: ⁠⁠https://bit.ly/4h6KHAD⁠⁠ A-GAME: “ULTIMATE15” FOR 15% OFF: ⁠⁠http://bit.ly/4kek1ij⁠⁠ PEPTUAL: “TUH10” FOR 10% OFF: ⁠⁠https://bit.ly/4mKxgcn⁠⁠ CARAWAY: “ULTIMATE” FOR 10% OFF: ⁠⁠https://bit.ly/3Q1VmkC⁠⁠ HEALF: 10% OFF YOUR ORDER: ⁠⁠https://bit.ly/41HJg6S⁠⁠ RHO NUTRITION: “ULTIMATE15” FOR 15% OFF: ⁠⁠https://bit.ly/44fFza0⁠⁠ GOPUFF: GET YOUR FAVORITE SNACK!: ⁠⁠https://bit.ly/4obIFDC⁠⁠ GENETIC METHYLATION TEST (UK ONLY): ⁠⁠https://bit.ly/48QJJrk⁠⁠ GENETIC TEST (USA ONLY): ⁠⁠⁠https://bit.ly/3Yg1Uk9⁠⁠ Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YT: ⁠⁠https://bit.ly/3RPQYX8⁠⁠ Podcasts: ⁠⁠https://bit.ly/3RQftU0⁠⁠ Connect with Gary Brecka IG: ⁠⁠https://bit.ly/3RPpnFs⁠⁠ TT: ⁠⁠https://bit.ly/4coJ8fo⁠⁠X: ⁠⁠https://bit.ly/3Opc8tf⁠⁠ FB: ⁠⁠https://bit.ly/464VA1H⁠⁠ LI: ⁠⁠https://bit.ly/4hH7Ri2⁠⁠ Website: ⁠⁠https://bit.ly/4eLDbdU⁠⁠ Merch: ⁠⁠https://bit.ly/4aBpOM1⁠⁠ Newsletter: ⁠⁠https://bit.ly/47ejrws⁠⁠ Ask Gary: ⁠⁠https://bit.ly/3PEAJuG⁠⁠ Timestamps 00:00 Intro of Show 02:20 Healing the Skin from the Inside Out 06:41 Biomarkers for Accelerated Skin Aging 10:17 Link between Stress and Skin 12:51 Clean Movement in the Beauty Industry 18:04 Inflammatory Skin Conditions 19:13 What's Causing Skin to Age Quickly? 24:55 Exosomes in Skincare Products 32:02 Collagen, Elastin, Fibrin Definitions 36:26 What Happens to Women's Skin during Perimenopause? 43:37 Hormone Replacement Therapy and Peptides on Women 48:03 New Breed Skin Technology 54:05 Less is More for Skincare 1:04:09 What does it mean to you to be an Ultimate Human? The information provided here is for general informational purposes only and should not be considered as medical or clinical advice. It is not intended to diagnose, treat, cure, or prevent any health condition, and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or other qualified health provider with any questions you may have regarding a medical condition or health objectives. The use of any information provided is solely at your own risk, and the provider of this information is not liable for any consequences arising from its use. Disclosure: Some links to certain products or services are affiliate links, meaning we may earn a commission. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of From Lab to Launch, we're excited to welcome Mariano García-Valiño, a four-time entrepreneur and CEO of Axenya, one of Newsweek's World's Best Digital Health Companies. He's built and exited firms worth billions, blending tech, data science and human-centered care to transform healthcare across the globe.Mariano brings deep insights into scaling companies, AI in healthtech, and the future of innovation in Latin America. His Amazon #1 bestseller, Inedible, explores the curious resistance of the healthcare sector to the software-led transformations that we've seen in other industries. He's also an experimental art photographer.Mariano joined Meg for a fascinating chat about the lessons he's learned leading his company, the role of tech in healthcare, and what the future of a stubbornly 'inedible' sector looks like. Qualio website:https://www.qualio.com/ Previous episodes:https://www.qualio.com/from-lab-to-launch-podcast Apply to be on the show:https://forms.gle/uUH2YtCFxJHrVGeL8 Music by keldez

El 21 de enero de 1908 nació en La Habana Julio Valdés Brito Ibáñez quien muy pronto, por motivos artísticos, fue reconocido en el ambiente musical de su tiempo como Julio Brito. Aunque destacó más en su faceta de compositor comenzamos este breve segmento recordando su etapa inicial como cantante. Para ello contamos con el catálogo de la etiqueta norteamericana Víctor de mediados de los años 30. Dos piezas completaban entonces el repertorio del juvenil Julio Brito: la versión que acabamos de escuchar de "La cachimba de San Juan", una guaracha de Ignacio Piñeiro, y "Tus lágrimas", un son que firma su hermano Alfredo Brito quien al frente de la Orquesta "Siboney" propiciaba el acompañamiento. En la delantera de la Orquesta Siboney incursionaba en el canto, a dúo con Julio, su hermana Nena Brito. Julio Brito, importante músico y compositor dejó clásicos como la hermosa guajira "El amor de mi bohio" y el bolero "Mira que eres linda". Los cantan Guillermo Portabales y Gerardo Pedroso con la Orquesta Gris. Otras dos piezas de su autoría nos acompañan en las voces de Panchito Riset y Abelardo Barroso: "Flor de ausencia" y "El Guajeíto". Las antenas de las veteranas emisoras habaneras nos devuelven a continuación algunos de sus tesoros más preciados. Voces que no deberíamos olvidar pues en su momento contribuyeron a difundir y a cimentar cultura dentro y fuera de Cuba. El depurado estilo de la olvidada cantante Rosita Sánchez no tiene nada que envidiarle a las voces más reconocidas del panteón musical cubano. Integró alguna vez el trío García. Hoy vuelve a acompañarla con su guitarra el trovador Nené Ayué. Maria Teresa Vera y Lorenzo Hierrezuelo, durante toda la década del 40, contaron con el apoyo del mago de la radio independiente cubana: Laureano Suárez. Suaritos, a partir de 1937 comenzó a escribir su propia historia en el dial radiofónico cubano produciendo innumerables grabaciones, únicas en formato y estilo. La soprano de coloratura Xiomara Alfaro y el bien llamado Príncipe del Feeling: Luis García nos recuerdan los tiempos de grandeza e independencia de la radio cubana. Sintonizaremos la señal de "La onda de la Alegría", Radio Progreso. Los acompaña la jazz band Hermanos Castro. Por esos caprichos de la memoria el nombre del compositor Benigno Echemendía Oliva no es reconocido como debiera, teniendo en cuenta la incidencia que ha tenido su carpeta autoral en el poderoso cauce de la música popular cubana. Valiéndose de géneros tan raigales como el son montuno, la guaracha, la rumba, el guaguancó y el bolero, comenzó a ganar prestigio en el ambiente musical a mediados de los años 50 cuando sus temas los tuvieron en cuenta agrupaciones soneras de primera linea incluyéndolos en bailables y producciones discograficas. Entre ellos los conjuntos "Modelo", "Estrellas de Chocolate", "Rumbavana" y "Chappotin". Cronista de su tiempo, siempre atento a lo cotidiano, fiel a la veterana escuela de los compositores cubanos. Con otra de sus formidables creaciones despedimos este breve segmento recordando su legado. "La Iyawó" es un guaguancó que en 2012 recrearon de manera formidable "el trombón de Santa Amalia": Juan Carlos Marín y el trompetista Julito Padrón. Y en espera del más reciente trabajo discográfico del "trombón de Santa Amalia": Juan Carlos Marín, volvemos a la producción de la etiqueta Bis Music del año 2012 donde reunió a otros notables instrumentistas como Julito Padrón en trompeta, David Suárez en saxo tenor, David Alfaro en piano y Oliver Valdés en drums. Bobby Carcassés y Moraima Marín despiden el programa con los temas: "Emiliano Forever " y "Todo de tí".

7-day FREE trial of our Intermediate Spanish course, Spanish Uncovered: ⁠⁠www.storylearning.com/podcastoffer⁠⁠Join us on Patreon: ⁠⁠www.patreon.com/storylearningspanish⁠⁠Glossaryretumbar: to echo borrar: to erase exponerse: to be exposedvaler la pena: to be worth itcomo nuevo: good as newjugarse la vida: (expr.) to risk one's lifeFollow us on social media and more: ⁠⁠www.linktr.ee/storylearningspanish

Arranca APPLEaks 204, el primer episodio de 2026, y Apple no perdió el tiempo.Google se convierte en su socio estratégico en inteligencia artificial, dejando atrás a OpenAI, Anthropic y Perplexity.¿Fracaso interno o jugada maestra para ganar tiempo?Mientras tanto, Meta empieza a desarmar Reality Labs, el metaverso se apaga y la industria entra en una etapa de replanteos profundos.¿Valió la pena quemar miles de millones?También te cuento todos los rumores fuertes: • El iPhone 17 “económico” que puede ser el más interesante del año • El iPhone plegable, ultrafino, sin hendidura visible y con patente de Apple • El rediseño total de iOS, macOS y watchOS • Los chips M6 y la llegada del MacBook Pro con pantalla OLED • Y las gafas inteligentes de Apple con IA, ahora con Google en escenaUn episodio cargado de información, filtraciones y análisis realista:Apple no está liderando… pero tampoco está fuera del juego.

Axenya is rebuilding healthcare around chronic disease prevention through AI-powered continuous monitoring. Covering 100,000 lives in Brazil and processing 95 million clinical inferences monthly, the company pivoted from clinical technology provider to healthcare broker - achieving cash flow positive status before their Series A. In this episode of BUILDERS, I sat down with Mariano García-Valiño, CEO and Founder of Axenya, to learn how they spent $3 million building the "perfect product" before discovering no one would pay for it, why they acquired a small broker to unlock their revenue model, and their regulatory-constrained approach to geographic expansion. Topics Discussed: Axenya's shift from infectious disease to chronic disease management through wearables and AI The 12-month zero-revenue period after spending $3 million on product development Why doctors, patients, and health plans all failed as buyers despite clinical validation The broker acquisition that unlocked their business model Performance-based pricing: zero fees upfront, revenue from cost savings only Regulatory barriers determining expansion (Mexico viable, Argentina impossible, Europe requires model redesign) Field-force-driven GTM with 30+ salespeople for complex, high-ACV enterprise deals Path to cash flow positive before Series A and scaling playbook for 2026 // Sponsors: Front Lines — We help B2B tech companies launch, manage, and grow podcasts that drive demand, awareness, and thought leadership. www.FrontLines.io The Global Talent Co. — We help tech startups find, vet, hire, pay, and retain amazing marketing talent that costs 50-70% less than the US & Europe. www.GlobalTalent.co // Don't Miss: New Podcast Series — How I Hire Senior GTM leaders share the tactical hiring frameworks they use to build winning revenue teams. Hosted by Andy Mowat, who scaled 4 unicorns from $10M to $100M+ ARR and launched Whispered to help executives find their next role. Subscribe here: https://open.spotify.com/show/53yCHlPfLSMFimtv0riPyM

** Ponte en presencia de Dios. Trata de hablar con Él. ** 10 minutos son 10 minutos aunque te puedas distraer. Llega hasta el final. ** Sé constante. El Espíritu Santo actúa “a fuego lento” y requiere constancia. Audios de 10 minutos que te ayudan a rezar. Un pasaje del Evangelio, una idea, una anécdota y un sacerdote que te habla y habla al Señor invitándote a compartir tu intimidad con Dios. Busca tu momento, piensa que estás con Él y dale al play. Toda la info en nuestra web: www.10minutosconjesus.org diezminutosconjesus@gmail.com Para recibir cada día tu meditación por Whatsapp pulsa aquí: http://dozz.es/nu36t

Vali Höll is in the midst of one of the most dominant runs we've seen in World Cup DH racing, taking her third consecutive overall title and fourth consecutive World Championships win in 2025. And she did it despite her team, the YT Mob, shutting down mid-season amidst YT's ongoing financial struggles. Vali joins us to tell the story of her season, what happened with the Mob, how she pressed on regardless, how she ended up signing with Commencal for 2026, and a whole lot more.RELATED LINKS:Blister Mountain Bike Buyer's GuideBLISTER+ Get Yourself CoveredBlister Podcast Ep.388TOPICS & TIMES:The YT Mob & YT's insolvency (2:50)Team contracts & how the season unfolded (5:13)Racing after team funding was cut (18:11)Talks with other teams & moving to Commencal (23:45)Consistency & race results (25:25)Racing for a new contract & managing pressure (27:52)Bikepacking & gravel bikes (31:20)Vali's goals for 2026 (35:21)CHECK OUT OUR OTHER PODCASTS:Blister CinematicCRAFTEDGEAR:30Blister Podcast Hosted on Acast. See acast.com/privacy for more information.

Rætt er við Lindu Gunnarsdóttur yfirflugstjóra Icelandair um fyrirhugaðar ráðningar flugmanna í millilandaflug félagsins. Á annað hundrað flugmenn misstu vinnuna þegar Play fór í þrot í haust og nú auglýsir Icelandair eftir fólki með reynslu á þotu. En hvað á að ráða marga og hvaða vélum eiga þeir að fljúga? Linda svarar þessum spurningum og fleirum í þættinum þar sem farið er stuttlega yfir ferlið framundan, inntökuprófin, þjálfanir, "cadet" prógrammið og fleira.

Mucha gente dejó todo en sus países de origen para venir a trabajar y tener una mejor vida en Estados Unidos, pero ahora, con las cosas como están te preguntamos ¿Y si lo piensas un poco más? Mantente al día con los últimos de 'El Bueno, la Mala y el Feo'. ¡Suscríbete para no perderte ningún episodio!Ayúdanos a crecer dejándonos un review ¡Tu opinión es muy importante para nosotros!¿Conoces a alguien que amaría este episodio? ¡Compárteselo por WhatsApp, por texto, por Facebook, y ayúdanos a correr la voz!Escúchanos en Uforia App, Apple Podcasts, Spotify, y el canal de YouTube de Uforia Podcasts, o donde sea que escuchas tus podcasts.'El Bueno, la Mala y el Feo' es un podcast de Uforia Podcasts, la plataforma de audio de TelevisaUnivision.