Podcasts about Vali

Saca la copa de cristal, échale cerveza y levántala alto porque es miércoles, y ustedes saben que llegó el oasis en medio de su semana: ¡llegaron los mach0rr0s! Esta semana estuvo con nosotros Melissa “@guzabra” Guzmán, quien sacó a pasear toda las testosterona que no tiene Vali. En este episodio hablamos de la pelea del novio de Gaby Nalgas y La GoLda, el extraño junte de Valerie y Eliezer, y del puño que le metieron a Santini. Yovín anda relax corriendo jetsko, regresan los ‘royal rumbles' en La Placita, arrestan a Almighty y le pedimos al gobierno que suelten a un inocente vendedor de frituras. Free Pastelillo, puñeta!

Mariano García-Valiño is a healthcare technology entrepreneur and author who has founded and led multiple companies at the intersection of healthcare, software, and data, most recently as Founder, Chief Engineer, and CEO of Axenya, a digital health platform recognized by Newsweek and Galen Growth among the world's leading health-tech innovators. He has driven the growth, expansion, and successful exits of several major firms, including Bausch + Lomb (approx. 9B USD sale in 2013), Grupo Biotoscana (IPO around 1B USD in 2017), and M8 Pharmaceuticals (approx. 250M USD sale in 2023), and has also invested in and advised other healthcare and pharmaceutical ventures across Latin America.​Earlier in his career, García-Valiño held senior roles in global organizations such as Advent, Warburg Pincus, Aqua Capital, Pfizer, Lilly, and McKinsey, gaining broad international experience across the United States, Latin America, and Europe. He is the author of “INEDIBLE: How to Build the Modern, Tech-Enabled, Healthcare Experience,” a book that became a #1 Amazon best seller and Hot New Release in the United States, where he examines why healthcare has lagged in digital transformation and outlines how technology can enable more intelligent, connected, and preventive care.​In parallel to his business career, he is an experimental art photographer whose abstract work, exploring hyperobjects, entropy, and inter-temporality, has been exhibited in contemporary galleries and is held in private and museum collections in Argentina, Uruguay, Brazil, Colombia, Spain, and the United States. García-Valiño holds an Engineering degree from the Universidad de Buenos Aires, a Photography PC from Cornell University, and an MBA from Harvard Business School, where he studied as a Fulbright Scholar.LinkedIN page: https://www.linkedin.com/in/mgarciavalino/Book: https://a.co/d/05gLJOHHPhotography: https://mgarciavalino.com/Company: https://axenya.com/Connect and tag me at:https://www.instagram.com/realangelabradford/You can subscribe to my YouTube Channel herehttps://www.youtube.com/channel/UCDU9L55higX03TQgq1IT_qQFeel free to leave a review on all major platforms to help get the word out and change more lives!

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Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.

Serie: Jesús Pregunta | Marcos 8:34–38Hay logros que hacen ruido en la tierra… pero guardan silencio en el cielo.En este mensaje reflexionamos sobre una de las preguntas más confrontadoras de Jesús:“¿Qué beneficio obtienes si ganas el mundo entero pero pierdes tu alma?” (Marcos 8:36, NTV)El mundo mide el éxito por acumulación.Dios lo mide por rendición.En este sermón aprenderás:• Qué significa “alma” en el contexto bíblico• Qué representa “ganar el mundo” en nuestra generación• Por qué el aplauso terrenal no garantiza aprobación eterna• Y cómo seguir a Cristo implica negar el yo y rendir el corazónTu alma no fue negociada.Valió una cruz.Si este mensaje habló a tu corazón, compártelo con alguien más y suscríbete para seguir creciendo en fe y dirección.Centro Familiar Cristiano“Una Iglesia donde la fe crece, la esperanza revive y el propósito se activa.”#CuantoValeUnAlma #JesúsPregunta #Marcos8 #FeBíblica #ValorEterno #CristoEsElCentro #IglesiaCFC #PredicaciónCristiana #ReflexiónCristiana #CentroFamiliarCristiano

durée : 00:25:44 - Les Fêlés du Poitou Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.

Tři paralympiády, tři medaile – zlatá, stříbrná, bronzová. A k tomu řada dalších z evropských i světových šampionátů. Velkých sportovních úspěchů dosáhl handicapovaný plavec Arnošt Petráček z Jankova na Českobudějovicku. Kvůli rehabilitaci trávil od dětství hodně času v bazénu a plavání mu pomáhalo překonat nejrůznější životní situace.Všechny díly podcastu Jihočeši můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

durée : 00:23:57 - Les Fêlés du Poitou Vous aimez ce podcast ? Pour écouter tous les autres épisodes sans limite, rendez-vous sur Radio France.

Hostem Kilometrů Jiřího Ježka byl bývalý cyklista a v současnosti podnikatel František Raboň. Jak moc pro něj byly důležité osobní vztahy v profi týmu? Jak se zrodil jeho přesun z cyklistiky do byznysu? Nelituje toho, že skončil jako profík už v 31 letech? „Jako výhodu beru to, že jsem působil v týmech, kde se netvořily žádné skupinky, protože tam byli borci z mnoha národností,“ vzpomíná na profesionální kariéru Raboň. Jak je těžké oblékat hvězdy současné cyklistiky?

Libertópolis al medio día, martes 17-02-2026

Třeba Babylon na Domažlicku koncem minulého roku koupil kdysi vyhlášený hotel Praha, kam jezdili výletníci už za první republiky. Teď chystá jeho přestavbu na byty.

Los expertos de Fuera de Juego analizan lo sucedido en la definición del duelo entre Real Madrid y Benfica. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Your skin is screaming what your blood work is whispering. Dr. Shawana Vali transformed how I understand the visible signs of internal dysfunction, & it's not what the beauty industry wants you to hear. Those wrinkles, breakouts, & pigmentation issues? They're your body's warning system telling you about adrenal fatigue, hormone imbalances, & inflammatory cascades happening deep in your tissues. Ready to look 5 years younger by treating the root cause instead of chasing symptoms? CLICK HERE TO BECOME GARYS VIP!: ⁠⁠https://bit.ly/4ai0Xwg⁠⁠ Connect with Dr. Shawana Vali Website: ⁠⁠https://bit.ly/467cGNl⁠⁠  YT: ⁠⁠https://bit.ly/3NuM9TU⁠⁠  IG: ⁠⁠https://bit.ly/4a6SMV5⁠⁠  TT: ⁠⁠https://bit.ly/4quCzij⁠⁠  FB: ⁠⁠https://bit.ly/4jN5ICM⁠⁠  LI: ⁠⁠https://bit.ly/4pPtqj8⁠⁠  Thank you to our partners H2TABS: “ULTIMATE10” FOR 10% OFF: ⁠⁠https://bit.ly/4hMNdgg⁠⁠ BODYHEALTH: “ULTIMATE20” FOR 20% OFF: ⁠⁠http://bit.ly/4e5IjsV⁠⁠ BAJA GOLD: "ULTIMATE10" FOR 10% OFF: ⁠⁠https://bit.ly/3WSBqUa⁠⁠ SNOOZE: LET'S GET TO SLEEP!: ⁠⁠https://bit.ly/4pt1T6V⁠⁠ COLD LIFE: THE ULTIMATE HUMAN PLUNGE: ⁠⁠https://bit.ly/4eULUKp⁠⁠ WHOOP: JOIN AND GET 1 FREE MONTH!: ⁠⁠https://bit.ly/3VQ0nzW⁠⁠ AION: “ULTIMATE10” FOR 10% OFF: ⁠⁠https://bit.ly/4h6KHAD⁠⁠ A-GAME: “ULTIMATE15” FOR 15% OFF: ⁠⁠http://bit.ly/4kek1ij⁠⁠ PEPTUAL: “TUH10” FOR 10% OFF: ⁠⁠https://bit.ly/4mKxgcn⁠⁠ CARAWAY: “ULTIMATE” FOR 10% OFF: ⁠⁠https://bit.ly/3Q1VmkC⁠⁠ HEALF: 10% OFF YOUR ORDER: ⁠⁠https://bit.ly/41HJg6S⁠⁠ RHO NUTRITION: “ULTIMATE15” FOR 15% OFF: ⁠⁠https://bit.ly/44fFza0⁠⁠ GOPUFF: GET YOUR FAVORITE SNACK!: ⁠⁠https://bit.ly/4obIFDC⁠⁠ GENETIC METHYLATION TEST (UK ONLY): ⁠⁠https://bit.ly/48QJJrk⁠⁠ GENETIC TEST (USA ONLY): ⁠⁠⁠https://bit.ly/3Yg1Uk9⁠⁠ Watch  the “Ultimate Human Podcast” every Tuesday & Thursday at 9AM EST: YT: ⁠⁠https://bit.ly/3RPQYX8⁠⁠ Podcasts: ⁠⁠https://bit.ly/3RQftU0⁠⁠ Connect with Gary Brecka IG: ⁠⁠https://bit.ly/3RPpnFs⁠⁠ TT: ⁠⁠https://bit.ly/4coJ8fo⁠⁠X: ⁠⁠https://bit.ly/3Opc8tf⁠⁠ FB: ⁠⁠https://bit.ly/464VA1H⁠⁠ LI: ⁠⁠https://bit.ly/4hH7Ri2⁠⁠ Website: ⁠⁠https://bit.ly/4eLDbdU⁠⁠ Merch: ⁠⁠https://bit.ly/4aBpOM1⁠⁠ Newsletter: ⁠⁠https://bit.ly/47ejrws⁠⁠ Ask Gary: ⁠⁠https://bit.ly/3PEAJuG⁠⁠ Timestamps 00:00 Intro of Show 02:20 Healing the Skin from the Inside Out 06:41 Biomarkers for Accelerated Skin Aging 10:17 Link between Stress and Skin 12:51 Clean Movement in the Beauty Industry 18:04 Inflammatory Skin Conditions 19:13 What's Causing Skin to Age Quickly? 24:55 Exosomes in Skincare Products 32:02 Collagen, Elastin, Fibrin Definitions 36:26 What Happens to Women's Skin during Perimenopause? 43:37 Hormone Replacement Therapy and Peptides on Women 48:03 New Breed Skin Technology 54:05 Less is More for Skincare 1:04:09 What does it mean to you to be an Ultimate Human? The information provided here is for general informational purposes only and should not be considered as medical or clinical advice. It is not intended to diagnose, treat, cure, or prevent any health condition, and should not be used as a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of your physician or other qualified health provider with any questions you may have regarding a medical condition or health objectives. The use of any information provided is solely at your own risk, and the provider of this information is not liable for any consequences arising from its use. Disclosure: Some links to certain products or services are affiliate links, meaning we may earn a commission. Gary Brecka is the owner of Ultimate Human, LLC which operates The Ultimate Human podcast and promotes certain third-party products used by Gary Brecka in his personal health and wellness protocols and daily life and for which Ultimate Human LLC and / or Gary Brecka directly or indirectly holds an economic interest or receives compensation. Accordingly, statements made by Gary Brecka and others (including on The Ultimate Human podcast) may be considered promotional in nature. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode of From Lab to Launch, we're excited to welcome Mariano García-Valiño, a four-time entrepreneur and CEO of Axenya, one of Newsweek's World's Best Digital Health Companies. He's built and exited firms worth billions, blending tech, data science and human-centered care to transform healthcare across the globe.Mariano brings deep insights into scaling companies, AI in healthtech, and the future of innovation in Latin America. His Amazon #1 bestseller, Inedible, explores the curious resistance of the healthcare sector to the software-led transformations that we've seen in other industries. He's also an experimental art photographer.Mariano joined Meg for a fascinating chat about the lessons he's learned leading his company, the role of tech in healthcare, and what the future of a stubbornly 'inedible' sector looks like. Qualio website:https://www.qualio.com/ Previous episodes:https://www.qualio.com/from-lab-to-launch-podcast Apply to be on the show:https://forms.gle/uUH2YtCFxJHrVGeL8 Music by keldez

El 21 de enero de 1908 nació en La Habana Julio Valdés Brito Ibáñez quien muy pronto, por motivos artísticos, fue reconocido en el ambiente musical de su tiempo como Julio Brito. Aunque destacó más en su faceta de compositor comenzamos este breve segmento recordando su etapa inicial como cantante. Para ello contamos con el catálogo de la etiqueta norteamericana Víctor de mediados de los años 30. Dos piezas completaban entonces el repertorio del juvenil Julio Brito: la versión que acabamos de escuchar de "La cachimba de San Juan", una guaracha de Ignacio Piñeiro, y "Tus lágrimas", un son que firma su hermano Alfredo Brito quien al frente de la Orquesta "Siboney" propiciaba el acompañamiento. En la delantera de la Orquesta Siboney incursionaba en el canto, a dúo con Julio, su hermana Nena Brito. Julio Brito, importante músico y compositor dejó clásicos como la hermosa guajira "El amor de mi bohio" y el bolero "Mira que eres linda". Los cantan Guillermo Portabales y Gerardo Pedroso con la Orquesta Gris. Otras dos piezas de su autoría nos acompañan en las voces de Panchito Riset y Abelardo Barroso: "Flor de ausencia" y "El Guajeíto". Las antenas de las veteranas emisoras habaneras nos devuelven a continuación algunos de sus tesoros más preciados. Voces que no deberíamos olvidar pues en su momento contribuyeron a difundir y a cimentar cultura dentro y fuera de Cuba. El depurado estilo de la olvidada cantante Rosita Sánchez no tiene nada que envidiarle a las voces más reconocidas del panteón musical cubano. Integró alguna vez el trío García. Hoy vuelve a acompañarla con su guitarra el trovador Nené Ayué. Maria Teresa Vera y Lorenzo Hierrezuelo, durante toda la década del 40, contaron con el apoyo del mago de la radio independiente cubana: Laureano Suárez. Suaritos, a partir de 1937 comenzó a escribir su propia historia en el dial radiofónico cubano produciendo innumerables grabaciones, únicas en formato y estilo. La soprano de coloratura Xiomara Alfaro y el bien llamado Príncipe del Feeling: Luis García nos recuerdan los tiempos de grandeza e independencia de la radio cubana. Sintonizaremos la señal de "La onda de la Alegría", Radio Progreso. Los acompaña la jazz band Hermanos Castro. Por esos caprichos de la memoria el nombre del compositor Benigno Echemendía Oliva no es reconocido como debiera, teniendo en cuenta la incidencia que ha tenido su carpeta autoral en el poderoso cauce de la música popular cubana. Valiéndose de géneros tan raigales como el son montuno, la guaracha, la rumba, el guaguancó y el bolero, comenzó a ganar prestigio en el ambiente musical a mediados de los años 50 cuando sus temas los tuvieron en cuenta agrupaciones soneras de primera linea incluyéndolos en bailables y producciones discograficas. Entre ellos los conjuntos "Modelo", "Estrellas de Chocolate", "Rumbavana" y "Chappotin". Cronista de su tiempo, siempre atento a lo cotidiano, fiel a la veterana escuela de los compositores cubanos. Con otra de sus formidables creaciones despedimos este breve segmento recordando su legado. "La Iyawó" es un guaguancó que en 2012 recrearon de manera formidable "el trombón de Santa Amalia": Juan Carlos Marín y el trompetista Julito Padrón. Y en espera del más reciente trabajo discográfico del "trombón de Santa Amalia": Juan Carlos Marín, volvemos a la producción de la etiqueta Bis Music del año 2012 donde reunió a otros notables instrumentistas como Julito Padrón en trompeta, David Suárez en saxo tenor, David Alfaro en piano y Oliver Valdés en drums. Bobby Carcassés y Moraima Marín despiden el programa con los temas: "Emiliano Forever " y "Todo de tí".

In this spiritually uplifting episode of Sant Attar Singh Ji Jeevan Katha (Audio Book), we witness the long-awaited visit to Sri Panja Sahib Ji, a place eternally blessed by Sri Guru Nanak Dev Ji.While traveling from Abbottabad to Panja Sahib, divine will holds Sant Attar Singh Ji Mastuane Wale at Shahan Di Dheri, where an unbroken flow of Naam Simran and Gurbani Paath continues for nine months. The passing of Bhai Sunder Singh Ji becomes the moment that awakens Sant Ji's long-held yearning to complete the pilgrimage.Resolute in spirit, Sant Ji decides to proceed to Panja Sahib to place the sacred dust of Guru Nanak Dev Ji's lotus feet upon his forehead and bathe in the holy waters, bringing deep peace to body and soul.

Vypočujte si najnovší diel podcastu Motoring s Jurajom Šulhaňom, generálnym riaditeľom spoločnosti AVIS Slovensko. 

Espacio Deportivo de la Tarde 20 de enero 2026 Alex Cervantes y el Poli Toluco en este programa en donde "Ni sus luces" Pepe Segarra nos dejo como novias de rancho! No sabemos a donde se fue! See omnystudio.com/listener for privacy information.

7-day FREE trial of our Intermediate Spanish course, Spanish Uncovered: ⁠⁠www.storylearning.com/podcastoffer⁠⁠Join us on Patreon: ⁠⁠www.patreon.com/storylearningspanish⁠⁠Glossaryretumbar: to echo borrar: to erase exponerse: to be exposedvaler la pena: to be worth itcomo nuevo: good as newjugarse la vida: (expr.) to risk one's lifeFollow us on social media and more: ⁠⁠www.linktr.ee/storylearningspanish

Spolupracovník Postoja Andrej Žiarovský a redaktor Lukáš Krivošík sa v historicko-vojenskom podcaste rozprávajú o takzvanej Cambridgeskej päťke. Kim Philby a štvorica ďalších Britov donášali sovietskej tajnej službe počas druhej svetovej vojny a Studenej vojny. Čo ich motivovalo? Ako niektorí z nich zvládali utajovať svoju špionážnu činnosť aj napriek enormnej spotrebe alkoholu? A ako sa prezradili?

Arranca APPLEaks 204, el primer episodio de 2026, y Apple no perdió el tiempo.Google se convierte en su socio estratégico en inteligencia artificial, dejando atrás a OpenAI, Anthropic y Perplexity.¿Fracaso interno o jugada maestra para ganar tiempo?Mientras tanto, Meta empieza a desarmar Reality Labs, el metaverso se apaga y la industria entra en una etapa de replanteos profundos.¿Valió la pena quemar miles de millones?También te cuento todos los rumores fuertes: • El iPhone 17 “económico” que puede ser el más interesante del año • El iPhone plegable, ultrafino, sin hendidura visible y con patente de Apple • El rediseño total de iOS, macOS y watchOS • Los chips M6 y la llegada del MacBook Pro con pantalla OLED • Y las gafas inteligentes de Apple con IA, ahora con Google en escenaUn episodio cargado de información, filtraciones y análisis realista:Apple no está liderando… pero tampoco está fuera del juego.

Axenya is rebuilding healthcare around chronic disease prevention through AI-powered continuous monitoring. Covering 100,000 lives in Brazil and processing 95 million clinical inferences monthly, the company pivoted from clinical technology provider to healthcare broker - achieving cash flow positive status before their Series A. In this episode of BUILDERS, I sat down with Mariano García-Valiño, CEO and Founder of Axenya, to learn how they spent $3 million building the "perfect product" before discovering no one would pay for it, why they acquired a small broker to unlock their revenue model, and their regulatory-constrained approach to geographic expansion. Topics Discussed: Axenya's shift from infectious disease to chronic disease management through wearables and AI The 12-month zero-revenue period after spending $3 million on product development Why doctors, patients, and health plans all failed as buyers despite clinical validation The broker acquisition that unlocked their business model Performance-based pricing: zero fees upfront, revenue from cost savings only Regulatory barriers determining expansion (Mexico viable, Argentina impossible, Europe requires model redesign) Field-force-driven GTM with 30+ salespeople for complex, high-ACV enterprise deals Path to cash flow positive before Series A and scaling playbook for 2026 // Sponsors: Front Lines — We help B2B tech companies launch, manage, and grow podcasts that drive demand, awareness, and thought leadership. www.FrontLines.io The Global Talent Co. — We help tech startups find, vet, hire, pay, and retain amazing marketing talent that costs 50-70% less than the US & Europe. www.GlobalTalent.co // Don't Miss: New Podcast Series — How I Hire Senior GTM leaders share the tactical hiring frameworks they use to build winning revenue teams. Hosted by Andy Mowat, who scaled 4 unicorns from $10M to $100M+ ARR and launched Whispered to help executives find their next role. Subscribe here: https://open.spotify.com/show/53yCHlPfLSMFimtv0riPyM

S religionistou Jiřím Dyndou o víře praotce Čecha, rusalkách i domácích bůžcích a atraktivě Slovanů s nimiž se v průběhu věků identifikovaly rozmanité skupiny lidí. Moderuje Štěpán Sedláček.O tom, že Slované před přijetím křesťanství věřili v hromovládce Peruna nebo bohyni Mokoš a měli posvátné háje slyšel asi každý. Ale co o jejich náboženství a božstvech skutečně víme s ohledem na historické prameny a archeologické nálezy? Jak prožívali období po zimním slunovratu? A kdo vlastně byli v různých dobách Slované? A proč tato identita připadala rozmanitým skupinám lidí přitažlivá do té míry, že se stávali Slovany a přejímali jejich způsob života? A co ze slovanského pohanství přežilo po nástupu křesťanství? Nejen o tom v dalším Čtení s Respektem mluví religionista Jiří Dynda ze Slovanského ústavu AV ČR, který je autorem novém knihy Bohové a bohyně starých Slovanů (Vyšehrad, 2025). Ptal se ho Štěpán Sedláček.Pokud vás zajímá moderní pohanství. Doporučujeme tento podcastový rozhovor s religionistou Pavlem Horákem: Stará božstva se vracejí. Co hledají tisíce Čechů v pohanství?https://www.respekt.cz/podcasty/stara-bozstva-se-vraceji-co-hledaji-tisice-cechu-v-pohanstvi

** Ponte en presencia de Dios. Trata de hablar con Él. ** 10 minutos son 10 minutos aunque te puedas distraer. Llega hasta el final. ** Sé constante. El Espíritu Santo actúa “a fuego lento” y requiere constancia. Audios de 10 minutos que te ayudan a rezar. Un pasaje del Evangelio, una idea, una anécdota y un sacerdote que te habla y habla al Señor invitándote a compartir tu intimidad con Dios. Busca tu momento, piensa que estás con Él y dale al play. Toda la info en nuestra web: www.10minutosconjesus.org diezminutosconjesus@gmail.com Para recibir cada día tu meditación por Whatsapp pulsa aquí: http://dozz.es/nu36t

Vali Höll is in the midst of one of the most dominant runs we've seen in World Cup DH racing, taking her third consecutive overall title and fourth consecutive World Championships win in 2025. And she did it despite her team, the YT Mob, shutting down mid-season amidst YT's ongoing financial struggles. Vali joins us to tell the story of her season, what happened with the Mob, how she pressed on regardless, how she ended up signing with Commencal for 2026, and a whole lot more.RELATED LINKS:Blister Mountain Bike Buyer's GuideBLISTER+ Get Yourself CoveredBlister Podcast Ep.388TOPICS & TIMES:The YT Mob & YT's insolvency (2:50)Team contracts & how the season unfolded (5:13)Racing after team funding was cut (18:11)Talks with other teams & moving to Commencal (23:45)Consistency & race results (25:25)Racing for a new contract & managing pressure (27:52)Bikepacking & gravel bikes (31:20)Vali's goals for 2026 (35:21)CHECK OUT OUR OTHER PODCASTS:Blister CinematicCRAFTEDGEAR:30Blister Podcast Hosted on Acast. See acast.com/privacy for more information.

Send us a textEpisode 142 of the Joint Dynamics Podcast JD host Andrew Cox | Joint Dynamics features Mariano García-Valiño. Mariano is a four-time health-tech entrepreneur and CEO of Axenya, a company revolutionizing healthcare with AI, advanced software, data science, and human-centered support. Mariano has led the creation, scaling, and exit of major companies including a $9 billion sale and a $1 billion IPO, with earlier roles at Pfizer, Lilly, McKinsey, and global investment firms. Beyond his business acumen, Mariano supports his drive and innovative mindset via his dedication to meditation and his work as an experimental art photographer, blending creativity and mindfulness to fuel his leadership. He is also the Amazon #1 bestselling author of "INEDIBLE," which explores why healthcare lags in technology adoption and how to fix it. Mariano holds an Engineering degree from Universidad de Buenos Aires and an MBA from Harvard Business School earned on a Fulbright Scholarship, underscoring his diverse expertise in entrepreneurship, technology, and human-centered innovation.Quick recap*Show sponsor is Muvitality Medicinal Mushrooms for modern day health and wellness | Mu …Go to muvitality.com and use the code JD10 to receive a 10% discount on your purchase of Mu Functional mushrooms such as Lions Mane, Cordyceps, Chaga, Reishi, and Turkey tail functional mushroomsEnjoyHere are some useful links for this podcastMariano's Book - Software is eating the world, yet healthcare remains INEDIBLE: How to Build the Modern, Tech-Enabled, Healthcare Experience - https://www.amazon.com/Software-eating-healthcare-remains-INEDIBLE-ebook/dp/B0FVGLQ1QF?ref_=ast_author_dp&th=1&psc=1www.mgarciavalino.comRelevant episodesEpisode 122 - Dr Christine Houghton on Genetics, Nutritional Biochemistry & Sulforaphane https://podcasts.apple.com/hk/podcast/episode-122-dr-christine-houghton-on-genetics-nutritional/id1527374894?i=1000699475907JOINT DYNAMICS links:Joint Dynamics Facebook - https://www.facebook.com/JointDynamicsHongKong/Joint Dynamics Instagram -https://www.instagram.com/jointdynamics/Joint Dynamics Youtube - https://www.youtube.com/channel/UCRQZplKxZMSvtc6LxM5WckwJoint Dynamics Website - www.jointdynamics.com.hk Host - Andrew Cox - https://www.jointdynamics.com.hk/the-team/trainers/andrew-cox

O Vánocích chceme být s blízkými a přáteli v hojnosti, bezpečí a teple. Ne každému se to poštěstí.

O Vánocích chceme být s blízkými a přáteli v hojnosti, bezpečí a teple. Ne každému se to poštěstí.Všechny díly podcastu Příběhy 20. století můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

O Vánocích chceme být s blízkými a přáteli v hojnosti, bezpečí a teple. Ne každému se to poštěstí.

Rætt er við Lindu Gunnarsdóttur yfirflugstjóra Icelandair um fyrirhugaðar ráðningar flugmanna í millilandaflug félagsins. Á annað hundrað flugmenn misstu vinnuna þegar Play fór í þrot í haust og nú auglýsir Icelandair eftir fólki með reynslu á þotu. En hvað á að ráða marga og hvaða vélum eiga þeir að fljúga? Linda svarar þessum spurningum og fleirum í þættinum þar sem farið er stuttlega yfir ferlið framundan, inntökuprófin, þjálfanir, "cadet" prógrammið og fleira.

Al calor de la exposición que actualmente se exhibe en el Centro Leonés de Arte (CLA), charlamos con la artista Ana Valiño, quien comisaria la exposición "Belita Gracia: la fotógrafa". Esta retrospectiva sobre esta pionera centenaria -aún viva, a sus 101 años- perteneciente a la emblemática saga de fotógrafos de los Gracia forma parte, en realidad, de un proyecto mucho más amplio con el que Valiño pretende reivindicar y dar visibilidad a aquellas leonesas con un papel notable en esta forma de arte.

Fe hecha canción es el programa de EWTN Radio Católica Mundial que promociona la música de los grupos y cantantes católicos del mundo hispano. Desde el Estudio 3 de Radio Católica Mundial, Douglas Archer comparte con ustedes una hora cargada de canciones, incluyendo las últimas novedades y estrenos, y de vez en cuando con algún invitado que canta o toca en directo.

04 11-12-25 LHDW R.Madrid 1 M.City 2: con echar huevos no valió para ganar. Vinicius y Bellingham señalados, lo del brasileño ya es preocupante

Después de años de espera desde su anuncio, Metroid Prime 4 Beyond finalmente ha llegado. ¿Valió la pena la espera?. Hablamos de eso y también compartimos nuestras Semanas Gamers y hablamos de las noticias más importantes, Game On! ¡Suscríbete Ya! Estamos en todas partes para que puedas escucharnos cuando quieras y donde quieras. Enlace a todas las formas de escuchar el podcast y las redes sociales: https://sumpodcast.blogspot.com/2019/01/enlaces-todas-las-formas-de-escuchar-e.html Notas del Episodio: https://sumpodcast.blogspot.com/2025/12/semana-gamer-368.html Todo el material de terceros fue usado bajo la condición de “Fair Use”.

Prvi program Radia Slovenija in A1 Slovenija sta že deveto leto zapored združila radijsko oddajo za otroke s 60-letno tradicijo in Lahkonočnice, pravljice sodobnih slovenskih avtorjev. V oddaji Lahko noč, otroci! boste lahko tri zaporedne četrtke prisluhnili novim radijskim uspavankam. V prvem večeru vas bo v sladke sanje popeljala pravljica Jane Bauer: Medvedov rojstni dan v interpretaciji dramskega igralca Aleša Valiča. Pripovedovalec: Aleš Valič. Avtorica besedila: Jana Bauer. Avtor glasbe: Rudi Pančur. Ilustrator: Miha Hančič. Fonetičarka: Mateja Juričan. Mojster zvoka: Matjaž Miklič. Režiserka: Špela Kravogel. Urednica oddaje Lahko noč, otroci!: Alja Verbole. Urednica Uredništva izobraževalnega, otroškega in mladinskega ter dokumentarno-feljtonskega programa: Špela Šebenik. Cikel pravljic za sladke sanje v okviru projekta Lahkonočnice v oddaji Lahko noč, otroci!. Posneto v studiu 02 Radia Slovenija, november 2025.

Mucha gente dejó todo en sus países de origen para venir a trabajar y tener una mejor vida en Estados Unidos, pero ahora, con las cosas como están te preguntamos ¿Y si lo piensas un poco más? Mantente al día con los últimos de 'El Bueno, la Mala y el Feo'. ¡Suscríbete para no perderte ningún episodio!Ayúdanos a crecer dejándonos un review ¡Tu opinión es muy importante para nosotros!¿Conoces a alguien que amaría este episodio? ¡Compárteselo por WhatsApp, por texto, por Facebook, y ayúdanos a correr la voz!Escúchanos en Uforia App, Apple Podcasts, Spotify, y el canal de YouTube de Uforia Podcasts, o donde sea que escuchas tus podcasts.'El Bueno, la Mala y el Feo' es un podcast de Uforia Podcasts, la plataforma de audio de TelevisaUnivision.

Por fin vamos a hablar de Frankenstein (2025) lo más nuevo de Guillermo Del Toro, proyecto que llevaba años con ganas de hacer. ¿Valió la pena la espera? Además de repasar la película y la historia, hablamos de varios Frankensteins más incluyendo la adaptación que hicieron de su historia en la serie de culto Penny Dreadful (2014) creada por John Logan. Me acompañaron en esta conversación la querida Berni "Lecturas de Berna" Ojeda y el querido Cristian "Filmico" Briones. Recuerden que podrían haber escuchado este capítulo antes de estar suscritos en www.patreon.com/hermeselsabio ¡no se pierda los pre-estrenos ni el material exclusivo! La tienda de Filmico la encuentra en www.filmico.tv Las recomendaciones de Berna en www.lecturasdeberna.cl

Flush de la semana con lo mejor en noticias que se dieron en la semanadéjame tu comentario Redes Sociales Oficiales:► https://linktr.ee/DrakSpartanOficialCualquier cosa o situación contactar a Diego Walker:diegowalkercontacto@gmail.comFecha Del Video[30-11-2025]#flush #amd #ram #nvidia #amd #conectores #gpu #fire #conectorgpu#drakspartan #drak #elflush

Už roky patří do hereckého světa a dobře ji znají nejen divadelní, ale i televizí diváci. Co pro ni herectví znamená? Co ji jako herečku nejvíc proměnilo? A proč je podle ní zásadní humor? I o tom v pořadu Až na dřeň mluvila herečka Lenka Termerová.

Neste episódio do Canary Cast, Kristian Huber, General Partner do Canary, conversa com Mariano García, Founder e CEO da Axenya, empresa que está transformando como as empresas brasileiras gerenciam a saúde de seus colaboradores por meio de dados, tecnologia e um modelo de negócio alinhado aos interesses de todos os atores da cadeia. A Axenya nasceu de uma tese simples, mas poderosa: o mercado de saúde precisa ser atualizado, e não há melhor momento para iniciar essa mudança do que agora. Criado em 1935 para lidar principalmente com doenças agudas (curta duração e alta intensidade), o sistema de saúde sofre hoje com mais de 85% dos custos relacionados a doenças crônicas — um volume para o qual ele não foi desenhado e que acaba desequilibrando as contas de diversos elos da cadeia, recaindo principalmente sobre os pagadores. Enquanto a tecnologia médica avançou significativamente no tratamento de doenças agudas, a expectativa de vida aumentou, a ocorrência de doenças crônicas se estendeu ao longo da vida e o sistema não se adaptou para acompanhar necessidades como monitoramento contínuo, prevenção e intervenção no momento certo. O resultado? Hoje, aproximadamente 50% dos custos de saúde estão relacionados a ineficiências de monitoramento e falta de ação preventiva — não ao volume de atendimentos, medicamentos ou procedimentos médicos em si. A solução que Mariano desenvolveu com a Axenya, apoiado em seus muitos anos na indústria de saúde, foi construir uma plataforma de gestão que agrega dados de múltiplas fontes (wearables, registros médicos, comportamento), os processa em tempo real e identifica populações em risco para intervir antes que doenças se agravem. Hoje, com uma população de 100 mil vidas sob monitoramento, a Axenya realiza mais de 95 milhões de análises clínicas por mês — um volume que seria impossível de executar mesmo se todos os médicos do Brasil trabalhassem exclusivamente para a empresa. No episódio, Mariano compartilha sua trajetória de 25 anos no setor de saúde — passando por Pfizer, Warburg Pincus, Bausch, Empresas de Biotecnologia e Advent — e como essa experiência o levou a identificar a oportunidade de reinventar a forma como empresas compram e gerenciam planos de saúde. Ele explora os principais desafios do mercado, como o desalinhamento de incentivos entre corretoras, planos e pacientes, e como a Axenya está rompendo esse ciclo ao se remunerar apenas pelo valor que entrega — e não pela comissão sobre o que é gasto.Destaques do episódio: 00:00 – 02:20 Introdução do episódio e apresentação do convidado02:28 – 07:20 Trajetória de Mariano Garcia no setor de saúde: de Pfizer a empreendedor07:22 – 09:40 O início da tese da Axenya a partir da ascensão do volume de dados em saúde09:44 – 14:35 As dores do setor de saúde: quais são os principais vetores de custo e o desalinhamento de incentivos14:35 – 17:33 Por que empreender com saúde no Brasil especificamente17:33 – 19:11 O que Mariano aprendeu como investidor, executivo e empreendedor que leva para a Axenya19:23 – 21:30 Complexidade de dados e os pontos de inflexão que permitem a solução da Axenya existir21:37 – 24:50 Proposta de valor da Axenya: como entrega valor para cada elo da cadeia (empresa, plano, paciente)25:00 – 27:00 O paradoxo da Axenya: mais consultas e exames, mas 50% menos de custos28:00 – 31:25 Quem é o cliente Axenya hoje e como quebra a resistência do mercado tradicional31:27 – 32:13 Modelo de negócio: monetização por success-fee em vez de comissão32:14 – 34:54 Quebrando a dinâmica anual de troca de planos: modelos de alinhamento de incentivos34:55 – 38:12 Os impactos da Axenya: redução de sinistralidade, eficiência de custos e NPS de 95+38:13 – 41:40 A visão de futuro: de otimizador de planos para plataforma completa de gestão de saúde41:42 – 44:30 Maiores erros, acertos e aprendizados sobre times e cultura44:48 – 47:10 A importância de pensar diferente do mercado: first principles vs. playbook47:16 – 48:19 Conselho para o Mariano do passado48:30 – 50:50 Conteúdos recomendados51:00 – 51:49 Conclusão do episódioConteúdos recomendados no episódio:"Redefining Healthcare: Creating Value-Based Competition on Results" de Michael Porter Livro seminal que introduziu o conceito de value-based healthcare há mais de 20 anos."Software is eating the world, yet healthcare remains INEDIBLE: How to Build the Modern, Tech-Enabled, Healthcare Experience" de Mariano García ValiñoMariano destaca que Porter escreveu sobre saúde baseada em valor de forma teórica, mas hoje, com as ferramentas tecnológicas disponíveis (como as que a Axenya usa), é possível colocar essas ideias em prática. É quase uma homenagem a Michael Porter, mas com a tecnologia que ele não tinha à época. "The Innovator's Prescription: A Disruptive Solution for Health Care" de Clayton Christensen Do mesmo autor que criou o conceito de "disrupção" e escreveu "The Innovator's Dilemma", este livro explora como inovação pode resolver os problemas estruturais da saúde. Apesar de ter cerca de 15 anos, mantém sua relevância e é essencial para entender dinâmicas de inovação em saúde. "The Cold Start Problem: Using Network Effects to Build Great Products" de Andrew Chen Livro focado em como construir marketplaces e ativar network effects. Essencial para quem está construindo plataformas que dependem de múltiplos atores (empresas, planos, pacientes, provedores) e precisa entender a dinâmica de como fazer todos os lados funcionarem simultaneamente. Glossário de termos mencionados ao longo do episódio: Doenças Crônicas — Condições de saúde de longa duração (diabetes, hipertensão, obesidade, doenças cardiovasculares) que exigem monitoramento contínuo e não têm cura, apenas controle. Doenças Agudas — Condições de saúde de curta duração e alta intensidade (infecções, fraturas) para as quais o sistema de saúde foi originalmente desenhado em 1935-1940. Sinistralidade — Percentual do prêmio de seguro que é gasto efetivamente em saúde. Exemplo: 75% de sinistralidade significa que de cada 100 reais em prêmio, 75 são gastos com saúde. Wearables — Dispositivos (smartwatches, pulseiras) que coletam dados de saúde em tempo real, como frequência cardíaca, passos, sono, etc. Monitoramento Remoto — Acompanhamento contínuo da saúde de pacientes sem necessidade de presença física, usando tecnologia e dados. Lead Qualification / Qualificação de Leads — Identificar e priorizar pacientes em risco que precisam de intervenção preventiva. NPS (Net Promoter Score) — Métrica que mede a satisfação e lealdade do cliente, variando de -100 a +100. B2B (Business-to-Business) — Modelo de negócio entre empresas. No caso da Axenya, vende para empresa → plano de saúde → paciente. Corretora de Seguros — Intermediária tradicional que vende planos de saúde para empresas, geralmente cobrando comissão sobre o valor do plano. Success-Fee — Modelo de remuneração baseado em resultados: a empresa paga apenas pela economia ou valor entregue, não por comissão fixa. Inflação Médica — Crescimento dos custos de saúde que é 2,5x maior que a inflação geral da economia. Modelo de Negócio Alinhado — Quando os incentivos financeiros de todos os atores (empresa, plano, paciente, provedor) apontam para o mesmo objetivo: melhor saúde com menor custo. Fragmentação de Dados — Situação em que dados de saúde estão espalhados em múltiplos sistemas sem integração, dificultando análises e ações. Interoperabilidade — Capacidade de diferentes sistemas e fontes de dados se comunicarem e compartilharem informações. Algoritmos Preditivos — Modelos matemáticos que usam dados históricos para prever eventos futuros, como o risco de um paciente desenvolver diabetes. Processamento de Dados em Tempo Real — Análise e ação sobre dados conforme são gerados, não em lotes posteriores. Aderência (Medicamentosa) — Capacidade do paciente de seguir corretamente o tratamento prescrito (tomar medicamentos no horário, na dose correta). Estatinas — Classe de medicamentos usados para controlar colesterol, uma das prescrições mais comuns no mercado. Retinopatia — Complicação da diabetes que afeta a visão e pode levar à cegueira se não controlada. First Principles — Abordagem de resolução de problemas que volta aos fundamentos básicos em vez de seguir convenções ou playbooks estabelecidos. Playbook — Conjunto de estratégias e processos padronizados que o mercado segue tradicionalmente. IPO (Initial Public Offering) — Oferta pública inicial; quando uma empresa abre seu capital na bolsa de valores. Private Equity — Modelo de investimento onde fundos adquirem empresas privadas para operá-las e depois vendê-las com lucro. Venture Capital — Tipo de investimento focado em startups de alto potencial de crescimento.See omnystudio.com/listener for privacy information.

Review các phim ra rạp từ ngày 14/11/25TRUY TÌM LONG DIÊN HƯƠNG – T16Đạo diễn: Dương Minh ChiếnDiễn viên: Quang Tuấn, Ma Ran Đô, Nguyên Thảo, Hoàng Tóc Dài, NSND Thanh Nam Thể loại: HàiBáu vật làng biển Long Diên Hương bị đánh cắp, mở ra cuộc hành trình truy tìm đầy kịch tính. Không chỉ có võ thuật mãn nhãn, bộ phim còn mang đến tiếng cười, sự gắn kết và những giá trị nhân văn của con người làng chài.TRỐN CHẠY TỬ THẦN – T18Đạo diễn: Edgar WrightDiễn viên: Glen Powell, William H. Macy, Lee Pace,Thể loại: Khoa Học Viễn Tưởng, Phiêu LưuTrong bối cảnh xã hội tương lai gần, Trốn Chạy Tử Thần là chương trình truyền hình ăn khách nhất, một cuộc thi sinh tồn khốc liệt nơi các thí sinh, được gọi là “Runners”, phải trốn chạy suốt 30 ngày khỏi sự truy đuổi của các sát thủ chuyên nghiệp. KHÔNG BÔNG TUYẾT NÀO TRONG SẠCH – T16Đạo diễn: Christine KODiễn viên: Jung Ryeo-won, Lee Jung-eun, Jang Jin-hee,...Thể loại: Bí ẩn, Tâm LýAi rồi cũng nói dối… Một rạng sáng sau đêm bão tuyết, Do Kyung (Jung Ryeo-won) hốt hoảng lái xe đưa chị gái mình đến bệnh viện trong tình trạng đẫm máu. Ngay sau đó, nữ cảnh sát Hyun Joo (Lee Jung-eun) có mặt tại hiện trường và nhanh chóng cảm nhận được rằng sau những lời khai rối ren của Do-kyung là một sự thật đang bị che giấu. SƯ THẦY GẶP SƯ LẦY – T16Diễn viên: Pae Arak Amornsupasiri, Foei Patara Eksangkul, Thể loại: Hài, Tình cảmChuyến đi Nhật tưởng chừng đơn giản của nhà sư nghiêm khắc Luang Phi Pae bỗng rẽ sang hướng khó tin: vị hôn phu của em gái ông lại chính là một nhà sư Nhật Bản với quá khứ bí ẩn. Từ đó, những tình huống oái oăm, dở khóc dở cười nối tiếp nhau, tạo nên hành trình vừa hài hước vừa cảm động.NÚI TẾ VONG – T16Đạo diễn: Chia-Ying TsaiDiễn viên: Tào Hựu Ninh - Lưu Dĩ Hào - Viên Lễ LâmThể loại: Kinh DịỞ Đài Loan có một câu nói truyền miệng nổi tiếng về khu rừng dưới Núi Ngọc Sơn, rằng: “Nếu chẳng may lạc trong rừng mà thấy bóng người mặc áo mưa màu vàng thì tuyệt đối đừng đi theo.” Gia Minh (Lưu Dĩ Hào đóng), Ngọc Hân (Viên Lễ Lâm đóng) và An Vĩ (Tào Hựu Ninh đóng) là những người bạn thân trong câu lạc bộ leo núi ở trường đại học. Trong một chuyến leo núi, thay vì đi theo lộ trình ban đầu thì cả 3 lại liều lĩnh bước vào khu vực cấm đã được cảnh báo trong rừng và bị lạc đường. OÁN HỒN TRONG VALI – T16Thể loại: Thriller/Criminal/Horror Korea Soo-ah được tìm thấy lạnh lẽo trong chiếc vali…Cái cái chết bất thường tưởng là sự kết thúc nhưng lại là khởi đầu cho một cơn ác mộng kinh hoàng hơn. Linh hồn phẫn uất của cô bị mắc kẹt trong chiếc vali trở về hòng đòi lại công bằng từ hai kẻ thủ ác. G-DRAGON IN CINEMA [Übermensch] – T13Đạo diễn: JINHO BYUNDiễn viên: G-DRAGON, TAEYANG, DAESUNG, and CL,….Thể loại: Phim tài liệuG-DRAGON trở lại sau 8 năm với world tour [Übermensch], mở màn tại Goyang, Hàn Quốc. Phim tái hiện sân khấu đỉnh cao của G-DRAGON với loạt hit từ “Crooked”, “Who You?”, “HEARTBREAKER” đến các ca khúc trở lại bùng nổ như “PO￦ER” và “HOME SWEET HOME”.CHÚ THUẬT HỒI CHIẾN 0 (TÁI KHỞI CHIẾU) – T13Đạo diễn: Sunghoo ParkDiễn viên: Hanazawa Kana, Nakamura Yuichi, Uchiyama Koki,…Thể loại: Hoạt Hình, Thần thoạiChú Thuật Hồi Chiến 0 là phần anime điện ảnh chuyển thể từ tập tiền truyện [Chú Thuật Hồi Chiến (0) - Trường chuyên Chú Thuật Tokyo]. Khác với phần anime dài tập quen thuộc với Itadori cùng nhóm bạn, phần tiền truyện này sẽ xoay quanh một nhân vật chính khác - chàng thiếu niên bị nguyền rủa Okkotsu Yuta. Khi lời nguyền ếm lên cậu trở thành mối nguy cho xã hội, Yuta đã bị bắt giữ và buộc phải nhập học tại ngôi trường đào tạo Chú Thuật sư. -------------------------------------------#8saigon #truytimlongdienhuong #tronchaytuthan #suthaygapsulay #reviewphimrap

A story about how "everyone agrees" is the most dangerous lie in SaaS.This episode is for SaaS founders frustrated watching their solution solve real problems—but wondering why no one actually buys it.Most healthcare startups don't fail because their tech doesn't work. They fail because they can't find anyone willing to pay for it.Mariano Garcia-Valiño, Founder and CEO of Axenya, spent 18 months proving his preventive care model worked clinically—reducing diabetes costs by 20% and mortality risk by 18%. Then he spent another year without selling a single dollar because insurers, hospitals, and patients all had reasons not to care enough to pay.He found the answer by buying a healthcare broker and changing who he sold to: employers in Brazil who actually bear the cost and have the timeframe to benefit from prevention.This inspired me to invite Mariano to my podcast. We explore why solving the right problem for the wrong buyer kills traction—and how changing your business model changes who cares. Mariano shares how he rejected the obvious paths (selling to insurers, doctors, or patients) and instead built a broker model that aligns incentives with outcomes. You'll discover why clinical proof means nothing without economic urgency.We also zoom in on three of the 10 traits that define remarkable software companies:Acknowledge you cannot please everyoneMaster the art of curiosityAim to be different, not just betterMariano's story is proof that the best solution dies without the right buyer—and why changing your business model, not your product could be the easy way out.Here's one of Mariano's quotes that captures the challenge he faced:"It's one thing to actually see the problem and find a technical solution for the problem. It's a different thing to deploy it in the right place within a very complex value chain that has a lot of incentives that are not well aligned."By listening to this episode, you'll learn:Why solving a highly valuable and critical problem alone won't create a market without economic incentive alignmentWhat happens when you build for huge global humanity problems instead of expensive local onesWhy focusing on who pays reveals better opportunities than focusing on who usesHow buying your distribution channel creates stickiness competitors can't copyFor more information about the guest from this week:Guest: Mariano Garcia-Valiño, Founder and CEO at Axenya Website: axenya.com

Naš najbolj prijazen pokrovitelj T2 in njihova super ponudba Pripravljeni na prihodnost: https://www.t-2.net/pripravljeni-na-prihodnost-zanesljivih-povezavFejmrč na https://www.fejmici.si/Vaše težave: podcast.fejmici@gmail.comPoljubna enkratna donacija na: ⁠https://tinyurl.com/y2uyljhm⁠Mesečna finančna podpora možna na:3€ - ⁠https://tinyurl.com/yxrkqgbc⁠5€ - ⁠https://tinyurl.com/y63643l5⁠8€ - ⁠https://tinyurl.com/y62ywkmt⁠Motitelji:- Gašper Bergant⁠https://www.gasperbergant.si ⁠⁠https://www.instagram.com/gasper.bergant/  ⁠- Žan Papič⁠https://www.zanpapic.si ⁠⁠https://www.instagram.com/zanpapi/  ⁠Produkcija: Warehouse Collective⁠https://www.warehousecollective.si⁠Grafična podoba: Artex⁠https://www.facebook.com/artextisk

Ma a szexről beszélgetünk. Pontosabban a szexualitásról, mindenféle aspektusban. Vendégem szexuálpszichológus és nagyon izgalmas dolgokat mesél nekünk. A stúdióban Benke Vali Leria.

„Co se změnilo od začátku války? Začali jsme dostávat instrukce o tom, že vyučující musí vést hodiny jiným způsobem. Dostávali jsme přesné instrukce o tom, jak máme učit, začali jsme dostávat hotové prezentace a videa,“ popisuje učitel na ruské základní škole a spoluautor snímku Pan Nikdo proti Putinovi Pavel Talankin. Jaké vzpomínky si spojuje se začátkem invaze? A proč se rozhodl usadit v Česku? Poslechněte si rozhovor.Všechny díly podcastu Host Lucie Výborné můžete pohodlně poslouchat v mobilní aplikaci mujRozhlas pro Android a iOS nebo na webu mujRozhlas.cz.

„Co se změnilo od začátku války? Začali jsme dostávat instrukce o tom, že vyučující musí vést hodiny jiným způsobem. Dostávali jsme přesné instrukce o tom, jak máme učit, začali jsme dostávat hotové prezentace a videa,“ popisuje učitel na ruské základní škole a spoluautor snímku Pan Nikdo proti Putinovi Pavel Talankin. Jaké vzpomínky si spojuje se začátkem invaze? A proč se rozhodl usadit v Česku? Poslechněte si rozhovor.

Útvarpsþátturinn Fótbolti.net er frumfluttur í hlaðvarpi þessa vikuna. Elvar Geir, Valur Gunnars og Sæbjörn Steinke í Pepsi Max stúdíóinu. Besta deildin er burðarefni þáttarins en tvær umferðir eru eftir og KR gæti fallið á sunnudaginn. Valið er lið ársins úr liðunum í neðri hluta deildarinnar. Í lokin gerum við upp landsleikjagluggann en það stefnir í úrslitaleik gegn Úkraínu í Póllandi í nóvember.

In this edition of the Snake Oilers podcasts, three vendors pop in to pitch you all on their wares: Automated, AI-powered threat hunting with Nebulock Damien Lewke from Nebulock joins the show to talk about how its agentic AI platform can surface attacker activity out of all those “low” and “informational” findings your detection team doesn't have time to look at. Runtime security for hypervisors from Vali Cyber Austin Gadient from Vali Cyber stops by to talk about ZeroLock, its hypervisor security product. It's marketed as a counter-ransomware control but is just a generally useful security platform for virtualised environments. A secure mobile telco: Cape The only thing American cell providers love more than providing patchy coverage is getting their customers' data owned. Cape is here to change that. It's a security and anonymity-focussed virtual mobile network operator (MVNO) that's been spun up by a highly competent team. If we lived in the USA we would be customers, and a bunch of CISOs listening to this might want to consider Cape subscriptions for their workforce. This episode is also available on Youtube Show notes

From a small town to the Military, Vali became lost and overwhelmed. Her story is powerful. Saved by Jesus Christ in so many ways. Tune into this powerful episode to hear her story.Edited by Scott Storrs. Music rights given by Heather Foster.

Nepolapitelný stín, převaděč drobného vzrůstu s výborným sluchem, kterému pomáhala víra. Takový byl Josef Hasil. S jeho pomocí dokázaly desítky lidí utéct z komunistického Československa na Západ. Hasilův příběh inspiroval i filmové tvůrce. A není divu. Jeho životní osud vypadá jak nefalšovaný hollywoodský trhák.