Podcasts about lhr

高个子不等于更健康——腿长与身高的比例（LHR）才是隐藏的健康密码。最新45万人研究证实，这个基因决定的指标能独立预测15种心血管代谢疾病风险，其影响甚至超过身高本身。

Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.

This session was live-streamed on 26th January 2026. To stay up to date with all things AviaDev, sign up at https://www.aviadev.com/keep-me-updated As always, we are joined by our trusted pair — Behramjee Ghadially and Sean Mendis. Chapters: 2025 AviaDev Award winners announcements Ethiopian Airlines S26 network updates  Impact of updated US travel restrictions on Africa demand in 2026 Qatar Airways frequency increases to South Africa  TAAG's planned Guangzhou service on 787  Air Sierra Leone Banjul–London Gatwick  fastJet cutting LUN-HRE flights  Airlink increasing Lilongwe flights and looking at ordering 30 E175-E2s to replace E135/140 fleet. SAA-Cemair codeshare agreement Kenya Airways 777-300ER returns on LHR from June Uganda Airlines A330 issues  Air Tanzania finally launching Accra 28JAN26? Air Côte d'Ivoire longhaul schedule updates  WRAPUP Air Zimbabwe's US$775m turnaround and fleet replacement plan Delta's 787-10 order and implications for Africa Enugu Air's E195 expansion and virtual airline model Oman Air to Kigali? FlyNAS launching Abha to Addis Ababa 2x weekly Air Algerie 2x weekly ALG-NDJ-ADD starting March 2026

Transcript:Hey everyone, welcome back to the LHR podcast. It's been a while. We've been revamping a lot of stuff behind the scenes on our website… Source

Landing at an abandoned primary school netball court. Power banks safety, because nothing says "relaxing flight" like monitoring your electronics for spontaneous combustion. A true business class in Europe (but via LHR? We're too old for this lol). The never-ending boarding experience, aka playing angry Tetris. 380 landing interrupted, and a Beluga. When life gives you lemons (oranges, in that case), make it a Swiss stopover (listen to the end of the episode!). The soft and hard truth or airline customer service (that chat bot flight rebooking, woah). An AvGeek is always and AvGeek, even in holy places (what would you have said, if anything?). Iberia premium economy and the infinite legroom. A beautiful ode to airlines' years past (and that one technical stop that should still be one haha). The incredible growth of Istanbul Airport. Would you cook mid-flight?And yes, Paul could not remember the title of the movie "Airplane!", wtf.Thanks to everyone who have stuck with us for 150 episodes, you're the air beneath our wings — as a gift to you, since so many have asked for it, video is coming (check Youtube)The website Paul mentioned: Tickets to EverywhereThe book Alex mentioned: Airline Maps: A Century of Art and Design —Follow us, and comment on: Instagram - Bluesky - Threads - Mastodon - Twitter/XComment on each episode, and rate us, on SpotifyReview, and rate us, on Apple PodcastsComment, like, review, and rate us, on FacebookComment on YouTubeSearch for "Layovers" on any podcast service (some direct links are on our website)If we're missing one, or if you have any feedback, let Paul know on Instagram - Threads - Mastodon - Bluesky - Twitter/X

Join the hosts as they take you through all the news from around the world and across the UK.  In this week's show Wizz Air asks passengers to ‘pre-select' themselves for being offloaded from overbooked flights, British Airways faces a backlash over water bottle removal trial on some US flights, and some good news regarding UK funding to help disadvantaged youngsters become pilots and engineers. In the military: Some Airbus A321 aircraft are to be modified into “Flying Frigate” patrol jets by France and we discuss rumours that Boeing might resume production of the C-17 Globemaster III.    Nev's also got a nice interview clip from Pete The Irish Pilot as he speaks with Ady Dolan from NATS at LHR tower.    We'll also have the first look at some of the content that we gathered at last week's Duxford Air Show. It was a very busy show as usual and the weather was extremely hot to say the least! Take part in our chatroom to help shape the conversation of the show. You can get in touch with us all at : WhatsApp +447446975214 Email podcast@planetalkinguk.com or comment in our chatroom on YouTube.

Laser Hair Removal Progress Update She's three sessions deep into LHR and Sarah's feeling morose. While sifting through her feelings across several separate recordings, she discusses the stop-and-start nature of transition, the immateriality of intrusive thoughts, and the question of what comes next after laser has done its job. Intro Music is "Roll Up Your Sleeves" by Molly Noise: https://linktr.ee/MollyNoise. Help support Sarah financially at patreon.com/ltas, comradery.co/sarahzedig or ko-fi.com/sarahzedig for one-time donations. Find her posts on mastodon, bluesky, and tumblr. Take care of yourselves. Find out more at https://trans-questioning-podcast.pinecast.co

Today we look at skiing in Sweden and Hemsedal in Norway and we find out what it's like coaching your kids to be pro skiers. Plus we find out more about the European Sleeper service to Innsbruck and the Dolomites, as well as discovering what Crans Montana is like in September. Iain Martin was joined by four-time Winter Olympian and ski coach Emma Carrick-Anderson and Ben Nyberg, Managing Director at skiScandinavia. Intersport Ski Hire Discount Code If you're starting to plan your skiing for this winter, then I am delighted to confirm that Intersport are sponsoring The Ski Podcast for a second winter. That means that all podcast listeners can save money on your ski hire by using the code ‘SKIPODCAST' at intersportrent.com, or simply take this link for your discount to be automatically applied at the checkout.  SHOW NOTES   Emma was on the slopes in Saas Fee for our call (1:00) Mike Goar was the Keynote Speaker at Ski Launch (3:15) Listen to Iain's interview with Mike in Episode 204 Our equipment episodes start next week…with the ‘Best New Skis of 2024/25' Look out for Iain's interview with Vicky Gosling, CEO GB Snowsport coming in October (4:00) Mia Brookes took 2nd in the Snowboard Slopestyle at Cardrona, NZ (4:15) Chris Engelsman is the co-founder of European Sleeper (4:45) Find out how to travel to Crans Montana on Ski Flight Free (12:30) https://www.youtube.com/watch?v=egi96baRhjQ Iain took part in the Wildstrubel UTMB trail race (13:00) You can watch his race report here  There was a lot of early snow on the mountains (14:00) Crans Montana's acquisition by Vail Resorts went through in May Iain spoke with Pierre Henri Mainetti (14:30) In 2027 Crans Montana will host the Alpine Ski World Championships (16:00) In September 2025 the resort hosts the Mountain Bike World Championships (16:30) Listen to Iain's interview with Zak Carrick-Smith in Episode 200 (18:15) Emma took competed for Great Britain in four Olympics at Albertville, Lillehammer, Nagano and Salt Lake City (21:00) Listen to Iain's interview with Dave Ryding (22:30) Listen to Iain's interview with Lesley McKenna (24:30) Find out about Alain Baxter's non-bronze medal (25:00) The Ski Podcast is going to be supporting the Carrick-Smith boys this winter (27:30) Trysil in Norway featured in Episode 209 (32:00) There is a new direct weekly flight from LHR to Scandinavian Mountain Airport (32:45) Hundfjallet may be the shortest transfer in world at just 10 minutes (33:45) Other Swedish resorts include Salen Stöten, Sälen Lindvallen, Kläppen (36:00) Hemsedal in Norway is three hours from the airport (38:00) Feedback (40:00)   I enjoy all feedback about the show, I like to know what you think, especially about our features so please contact on social @theskipodcast or by email theskipodcast@gmail.com  AD: "Great pod Iain. Thanks for keeping this going over the summer, when most other ski related podcasts stop…roll on the autumn!" Camilla: “You are brilliant at drawing people out with great questions, creating really enjoyable podcasts.” Mark Wakeling: “Really enjoyed the Chemmy interview. From an early age just wouldn't take no for an answer and her infectious enthusiasm is inspiring.” Jim: “I was listening to the podcast the other day while hiking up a mountain. You were talking about where to get second-hand skis. At the beginning of the season, a lot of resorts organise Braderies where the local shops pool ex-hire or last season kit to sell in one convenient place. Another great option is shops like Trocsport which sell secondhand skis on behalf of individuals. There are loads of small shops like this.” There are now 226 episodes of The Ski Podcast to catch up with and 121 of those were listened to in the last week. You can do that too, there is so much to listen to in our previous episode, just go to theskipodcast.com and search around the tags and categories: you're bound to find something of interest.  In that last week, 60% of our listeners were in the UK, 11% were in the States and everyone else spread as far and wide as Turkey, Greenland and Mexico. If you like the podcast, there are three things you can do to help:    1) Follow us. Just take a look for that button and press it now  2) Give us a review or just leave a comment on Apple Podcasts or Spotify  3) Book your ski hire with Intersport Rent using the code ‘SKIPODCAST' or take this link You can follow me @skipedia and the podcast @theskipodcast

Ever wondered about the life of a flight attendant (and ground crew)? This is the episode for you. Paul welcomes his good friend Vinod for an episode full of fun aviation and travel stories — a long episode, with the laughs taking quite some of that length.From Edmonton to Vancouver, via Calgary (and its keys!), the many airports he worked at (Paul still hasn't been to Canada), Martinair, British Airways, Air Berlin, or WestJet, amongst the many airlines he worked for (and in a world of crew camaraderie around the world, BA really seems like a big family).Is there something about the uniform that transcends trends? And Vinod's secret to treat cabin crew well (Paul is inspired).The experience of turbulences in the air (and yes, we discuss that fateful Singapore Airlines flight), but also the video game of driving a jet bridge.Can you get Covid from an aircraft wing: flying during the pandemic to (and working at) Tokyo 2020 (NRT, a game of chairs) and Beijing 2022 (PEK, calcifying under sanitizing spray).Does each airline have a specific smell, or is that a neurotic avgeek thing? (dried fish seems like a bad omen though).  Vinod attempts to convince Paul that Frankfurt and Heathrow are great airports, and he nearly succeeds (his definition of LHR is just the best, and Paul softens on FRA), and we (kinda) agree on Singapore's carpet.And many more stories (Vinod's most memorable flights are quite something). Listen to Vinod Viswalingam's podcast (hosted along with the great Geoff Dahl), Seat 1A:Seat1A on Apple PodcastsSeat1A on SpotifySeat1A (website with more links)  

"Permission to podcast freely, Captain?"Made by Trekkies for Trekkies, "The Janeway Podcast Program" is a richly sound-designed chat show that delivers world-building recaps at warp speed.Every episode of the JPP takes place immediately after the events of a Star Trek: Voyager episode, so the characters can say how they REALLY feel about it. Relive the excitement of the show or listen as you watch for the first time.Embark on this podcast parody journey with the somewhat more relaxed, off-duty Captain Kathryn Janeway and her cohost, Ensign Brebb from Engineering.They'll gossip about the creepier members of the crew, mull over unsolvable time paradoxes that never actually occur (or do they?) and drink a lot of coffee, black. Featuring The Computer.Subscribe for free to LHR's Patreon for a sneak peak.See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Usually I lock up a summer trip as far ahead of time as possible. But due to the current award travel patterns and my need for 4 seats I found myself without a summer booking and a family wanting to travel. Today Robert and I chat about the ups and downs of the search for a summer trip, award space scarcity, alliance and search engine fragmentation and more. - Enjoy! 01:55 Let's talk about the Constraints of this trip: We didn't have a single destination on our list but rather a short list of places to go 2 Adults 2 children. 3:00 Summer, during Summer Break (June/July) Prices and awards rise dramatically in Jun/Jul and award space dries up even worse than it is during other parts of the year 4:24 No flexibility in cabin (I couldn't even pitch premium economy) As we've gotten older we've taken less trips, but put more into them. Last year we spent 36 years on vacation, but we're trending into longer trips 6:45 Don't want to reposition Saw some options through IAH, PHL. Also saw flights through Canada I don't like clearing customs and then having another flight, with little kids that is a pressure point 9:00 Point balances:  I'm a non-hoarder. I have about 250,000 Alaska, 400,000 AA and very little other miles on hand.  I do have a large MR and UR balance I can draw down. Otherwise I'll cash them out 9:53 AA out of LAX, comparing AA vs BA. points yeah served up LAX-LHR on AA with Alaska Miles: But AA wouldn't show this for a similar 'low' price But adding a leg--searching LAX-CPH showed the low price for the whole flight. This seems like a 'married logic' issue. It means pricing is end to end (LAX/CPH) vs segment by segment. This has become VERY common with dynamic pricing. This makes the old 'get over the pond' mentality dangerous. Searching between city pairs only for long-haul flights won't show you the whole picture (Not just on AA, across most airlines now). This is also a search engine fragmentation because you are relying on the search engine to do the routing logic. 15:41 Let's talk about award space out of LAX I've had an eye on LAX long haul routes for more than a decade. I've never seen it this thin That's on top of more capacity than ever, with better cabins than ever The 64,000 point question is: Will those seats get sold, or will they be released closer to the dates of travel Current space isn't a great indicator. There are very different people wanting to go to Europe in the next 2 months than in Jun/July 18:00 Quick discussion about the ‘loss' of partner award space This has made it more important than ever to hold flexible currencies like MR/UR/Cap 1 One ways with different currencies helps spread out the search net Ultimately you still need that triangle of flexibility we've talked about forever here: Dates, destination or class of service. You have to flex one (or more) of them.  Flights Have to Exist in order for you to take them Flightconnections.com is still the place i go to start any search I look for ALL long haul options out of LAX (remember I don't like to reposition) Some filtering is needed, because these are not all flights that can be booked with miles easily, but without a premium account you'll be limited to filtering by a single airline. 18:40 Options start coming into focus EF showed space on Air Tahiti Nui LAX-CDG in business. I've flow this before. It really isn't great, but it is a lie flat and the flight was an easy feeling one. Unfortunately with a few calls to AA agents none of them could see the space. I tried some other tricks but with no luck. I don't know what's going on there–if it is a block or phantom space From there I saw on pointsyeah some air france awards in the 130,000 per person (plus about $300 in fees).  I didn't love those so I went to Air france's site and started going day by day, looking at all flights i might want to take.  Ontario-TPE, LAX-Manchester, LAX-Oslo/stockholm/Helsinki/Rome.  And something interesting started to show up… The biggest issue is they don't always show you the partner space and they don't by default sort by lowest price in miles (not the only site that does this). Again going city pair by city pair pulled up an option, LAX-OSL for 4 passengers for about 72,000 miles and $225 each. There's a huge hurdle here: Foreign program, I have no miles in and have never used. I'm about to transfer 300,000 MR into it. This better be REAL space. Married logic makes it look even more phantom when you search LAX-CDG and find it is 700,000 per person. Almost makes you want to skiplag an award ticket. Of course people online are talking about phantom space biting them, and I just had that issue with TN and AA. So I called Flying Blue and asked for the rep to see the space, and put it on hold. And he did, which made me feel good about this space.  24:19 Still Need a Return -- Just as Uncertain as before But I still had no return. So the entire search starts again, but this time with even more restrictive constraints. It doesn't help me if I find a return from Tokyo-LAX– not the entire search has to be from Oslo, or somewhere nearby to LAX (or somewhere nearby). And I don't want to clear customs on the east coast with my kids, and have to keep picking up bags, so I'm looking at even less options. AA had an option through LHR. The fees were huge, but I was sure if i called I could get them lower by making the first leg in economy. Aeroplan had space on Air canada (not partner) through montreal in PE. This was not ideal–I didn't want to fly PE and would be putting miles into aeroplan that I would cancel and possibly orphan. 25:30 Let's discuss Stranding miles?  PE Vs J? Anything you like here?  The trend of moderately priced awards with native miles almost guarantees orphaned miles if you cancel a trip. That didn't used to be the case–but the lack of partner space makes it happen Beware expiration of miles (Asian carriers don't allow extending miles for example). 27:30 Book and then garden vs. wait and book   There are benefits to each approach, but drawbacks as well. I probably could have gotten the family on board with a situation like 2 in Business 2 in Premium. But I wasn't even seeing that option Nice upgrade of AA Miles being useful for JAL Premium economy.  31:06 Nothing is Free, Everything is Cash Luck–ultimately was the key. Immense luck in the form of 4 seats OSL-LAX on air france on the exact day I wanted to return at the lowest level I'd seen all search, an average of 48,000 per person (plus $320 in fees). With the outbound on hold I transferred enough for this return, booked it online (if it was phantom I would have used those miles for the outbound) and then transferred again to ticket the outbound on the phone. Total: 491,750 MR plus $2200 in fees.  $2200 in cash is 200,000 Membership rewards cashed out with schwab. Compare to an 88,000 United booking this is very close to the same thing A total of 691,750 MR for 4 people. Compares to Can't really do much to improve this or risk stranding these miles 37:41 This one shook out–but I don't want to let things slip past me like this.  Close in doesn't work for me, both with requesting days off of work and with planning trips So I need to remind myself to start looking NOW for winter break, and soon enough for Summer 2025.  Flex the demand schedule with your family too.

In an attempt to close out 2023 with something joyful, exuberant, new, and filled with a smattering of mostly Love (and a little Hate), LHR is proud to present what may become our new annual tradition, a holiday Tierlist. For our first outing, we're heading back to an old favorite ⁠Triple Love Topic⁠, the James …

Welcome to Episode 131 Sponsored by CultTVMan, Sean's Custom Model Tools and Return To Kit FormHostsStuart TerryThanks to our latest Patreon and Buy Me a Coffee Supporters:Check out our What We Like page for lists of what we like.***************************************LATEST NEWSTaking a seasonal break after this episode, see everyone in the new year.Creating a new ‘What we like page' with stuff we use and recommend, also books we have read.***************************************MAILBAGWe want to hear from you! Let us know if you have any comments or suggestions scalemodelpodcast@gmail.com. With the end of the year coming, Show us what you finished for the year.Hi All at Scale Model Podcast. Just want to thank you for a very informative and easy-listening podcast. It definitely helps me get through my days at work. Just catching up on the latest episodes and heard the update from Scale ACT 2023. It was the 1st time I'd attended and was an amazing show! I met up with some people in person for the 1st time who I have talked to for a few years on Instagram. We ended up going out for some refreshing adult beverages both nights of the weekend. I can definitely understand it when people say that it's the people that make the shows. During the episode, I heard you mention the Ram Kangaroo at the show. That was mine. It was the Gecko Models kit and it was a dream to put together. Here are a few more pics of it (attached). Keep up the great podcasting!! Nick - Social media: The Scale ArmourerGordon SorensenEnjoyed the latest podcast…I went to Telford for the first time this year. Montreal has direct flights to LHR, and it's about a 3 hour drive north-west from there.There are three large halls, totalling about 100,000 sq.ft. The 170+ different clubs and SIGs were situated in the middle of the halls, and 120+ vendors around were on the outskirts and along the walls.I displayed some models on the Danish SIG, and had a great time.I spent waaaay over my budget, but I justify it saying ´I am saving on shipping costs…'  ***************************************LATEST HOBBY ANNOUNCEMENTSDragon's new 48th scale Bf-109E-4MiniArt's 48th scale D-30RE Jug in CAD & ArtPart 2 with spru shots29 new products from Black DogGreat Wall's new 1/48 F-14AHobbyBoss JanuaryItaleri's December releasesAMT New tool 1960 Ford F-100 Pickup with Trailer (1/25) Revell releasing Stranger Things vehicles What's new at Scalemates.com ***************************************SPONSOR AD #1Cult TV Man***************************************TOPICEnd-of-year summaryGeneral discussion.Hi's and Lows of 2023***************************************WHAT'S ON THE BENCHStuart - Taking a brief break on the Moosaroo cup to figure out what I want to do in terms of the diorama. Got a larger base.Battle mechs are almost completed and deciding what to build next. YF-21 Perhaps.[foogallery id="3539"]Terry - Finished the Christmas Birds. Sanded and resurfaced the Lamda carrier decks, they were a bit rougher than I would have liked. I think they may be ready. Also went back to the Hasegawa Regault kit. I think I have no choice but to build, mask and paint it. I had thought I could paint parts first, but that's not going to work.[foogallery id="3540"]***************************************WHAT WE ARE READINGStuart - Coming of Age in the Milky Way by Timothy Ferris. Just getting into the 20th Century.Terry - Finished Ed Yong's An Immense World. Reading the second Elric collection by Moorecock. Also still reading the Reacher series of Graphic Novels.***************************************SPONSOR AD #2Seans Custom Model Tools***************************************THINGS WE'VE SEENGreat looking BattlemasterLuftraum/72 providing some interesting details on the painting of his F15-JTerry did visit the Museum of Pop Culture in Seattle. Some nice collections of movie props, and a Leika Studios special exhibit.  The paint rack I got was the hanging rack from Lazy Dog Studio. If you look at options you will find the size you need. Pro Acryl is the medium size cutouts.***************************************THE LAST WORD SMP Ep. 131 is also sponsored by Return To Kit Form (R2KF). Check out their web store!For more modelling podcast goodness, check out other modelling podcasts at modelpodcasts.comPlease leave us a positive review if you enjoy what we're doing!Check us out: FaceBook, YouTube, and our very own websiteWe also have merchandise now. Check it out on RedbubbleCheck out our What We Like page for lists of what we like. 

The glamour of international air travel is bouncing back - and Heathrow Airport bosses say they've got the passenger numbers to prove it.LHR revealed on Wednesday that the number of travellers was back above pre-pandemic levels for the first time.Airport bosses say more than seven million passengers took off or landed over September, soaring past 2019's figures of nearly 6.8 million travellers.The Leader podcast's joined by Evening Standard business editor Jonathan Prynn.Plus, latest on a major fire sparked by an exploding car at Luton Airport, where five people were taken to hospital and firefighters spent 12 hours battling the flames.Bedfordshire Fire and Rescue Service say their current hypothesis is the blaze started accidentally in the £20million Terminal Car Park Two. Hosted on Acast. See acast.com/privacy for more information.

It's spooky season and, to celebrate, we're sharing our pilot for "The Creepy Bar." We're really proud of this radio play and we hope to make more when we have extra bandwidth. Support from our Patrons helps us experiment with formats and gives us an opportunity to craft pieces that are more ambitious.“The Creepy Bar” is a comedy/horror anthology series hosted by Marcus the Bartender, a friendly man of mystery who has heard all sorts of terrifying tales.Music by Dan Warren! Who also composed LHR's classic main themes.In each episode of “The Creepy Bar,” Marcus will pour you a drink and entertain you with his spookiest stories.In this episode, Marcus (Frank Garcia-Hejl) welcomes a mysterious "Stranger" to The Creepy Bar. The Stranger tells the tale of an ambitious business man named Jason (James III) who buys a magical wish-granting hand from a pleasant witch. However, the hand has a terrible secret: it can grant “good wishes” as well as “bad wishes.”Jason learns that you should always be careful what you wish for… the hard way.Support LHR by joining our Patreon at patreon.com/lefthandedradio or leave a 5-star rating and review wherever you subscribe to our show.Visit our Tee Public page: https://www.teepublic.com/stores/left-handed-radiohttp://www.lefthandedradio.com/merchLeftHandedRadio.com | patreon.com/LeftHandedRadio | http://twitch.tv/lefthandedradio | facebook.com/LeftHandedRadio | instagram.com/lefthandedradio | twitter.com/LeftHandedRadio| lefthandedradio@gmail.com | https://www.tiktok.com/@lefthandedradioSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

For our new two-pronged format, LHR now brings a full episode of relationship questions for the second half of the month. We begin with Kevin and Vicky (American Pie), and the question of if it's weird for him to be looking up instructions on how to do foreplay while right in the moment. Andy emphasizes …

Drew talks about managing throught the Summer flight schedule and Doug is getting ready to head back to training, this time in Altus, Oklahoma, the middle of nowhere. Is it really the middle of nowhere though? Drew does some research and finds goat petting, corn shucking, and axe throwing to keep Doug occupied. We also discuss:Spirit Aerosystems and the IAM reach a tentative agreement to avoid a strike and delays to 737 and 787 deliveriesQantas details its A350 cabin layout for its Project Sunrise flights to LHR and JFK - spoiler, there's a lounge and its not for first classSpirit Aerosystems make the whole fuselage of the 737 and many parts for the 787. Should Boeing buy them? Slide deployments - why do they happen? How much do they cost to repair , and why is Doug scared every time he opens a door?Join the discussion! https://www.nexttripnetwork.com/

Andrew starts by talking about one of the aspects of flying that causes the most nervousness: turbulence. Then, the main segment for this episode looks at airport codes. Should we be afraid of turbulence? While turbulence can be nerve-wracking even for frequent flyers, there isn't all that much to be worried about. Learn more in this episode and check out Andrew's chat with airline pilot Owen Zupp about turbulence in Episode 8 for more.  JFK, LHR, SYD – these airport codes clearly represent New York's JFK Airport, London Heathrow, and Sydney Airport. But these airports also have the codes of KJFK, EGLL, and YSSY. Why is this, what are these codes used for, and what do they mean? Find out more in this episode. Did you know that there's a single airport with three airport codes? Andrew talks about where this unique airport is located and why it has so many codes.If you're enjoying Flying Smarter, please take a minute to leave a five-star review for the podcast if you're listening on a platform that allows you to do so like Apple Podcasts, Spotify, or Goodpods. It helps the grow the podcast and convince guests to come on the show and we would greatly appreciate it! Connect with Flying Smarter: Facebook: Flying Smarter Podcast Instagram: @flyingsmarter Twitter: @flying_smarterLinkedIn: Flying SmarterWebsite: www.flyingsmarter.com  

QUESTION OF THE WEEK (from the group)1. Chris Hick: “ Are there any pros/cons of booking through Avianca vs Air Canada? I don't mind paying a little more if it's a better or easier experience.”NEWS & ENHANCED OFFERS Korean Air - announced & suspended award chart changes in short period - curious what happenedEtihad Guest - alluded to this last episode - before that happens, AT101 moderator Jerod Morales shares some of the sweet spots Citi Transfer Bonus - 62K Virgin Voyage, ANA Business Class for 37K & First for 47K One-way, Delta One at 39K One-way to EU, or flights on Virgin metal starting in Economy at 9K even from places like LAX to LHR for 15K in PE Hyatt Promo & Status Hacking- World of Hyatt members can earn 3,000 Bonus Points for every two eligible nights, up to 30 nightsWHAT BONUSES DID WE GET? United BusinessBoth AA (Citi & Barclay) cards arrivedAlmost done with 60K business checking (now 30K)4/24 P2 2/24 - what should I get next?Should you be using AwardWallet?AwardWallet tracks almost  700 popular travel and loyalty programs? They also have a ton of other tools that are helpful too, including: Tracking hotel certificatesA built-in travel itinerary Airline change/cancellation notices, often before the airline do, so you can get ahead of the gameProvides detailed analysis of how you could earn more points based on your unique spending habits Individual Transaction Analyzer to show you each transaction and how you didAs well as the Merchant & Reverse merchant lookup tools that will tell you if a specific retailer will earn you MORE bonus POINTSYOU should have AwardWallet,  BECAUSE IT'S FREE! More advanced features cost $30 annually. If you think you're ready for that and are interested in the intermediate level Award Travel 201 community for $89.99 annually, AND AW+ is included in your AT201 subscription.TRIP UPDATES? Angie's - positioning flights for Africa and Balibooking flights for meetupsJoe - Figuring out how to get home from Andaz Mayakoba Weekend trip to Atlanta - points save how much?WHAT YOU DIDN'T KNOW Meetups & their importance - did you know how Angie, Allison, and I met?Increase your knowledgebuild friendships AND your contact listlearn some of the secrets that enhance your Award Travel experienceWhere To Find UsFor questions, you can join us in the FREE 91,000+Where To Find the Award Travel 101 Community For questions, you can join us in the free 100,000+ member Award Travel 101 Community. For more intermediate and advanced strategies, join Award Travel 201 community To book time with our team, check out Award Travel 1-on-1. You can also email us at contactawardtravel@gmail.com. Our next meetup is located in San Antonio, TX on April 26–28, 2024, and it's SOLD-OUT. You can get on our wait-list, but to learn more visit Taco 'Bout A Fiesta! Support the AT101 Podcast/Community

How is it we had never actually done MAD as an episode title? This ends today, however the mad MADrid dash from T4S to T4 never does. Alex has lots to say about BA and it's …not great (he's not alone to think like this). Paul calls it, the better London airport is definitively Gatwick (stop being a wannabe posh by preferring LHR). Lufthansa introduces a grand new First Class, and a super complex Tetris business class with 14+ options (Swiss introduces the same, but in bordeaux). Will Dolomiti be folded into ITA (the ever growing Lufthansa Group realm of the European skies). Emirates is the Apple of airlines, you might not love them but they offer incredible consistency at massive scale, truly admirable (DXB could do with a bit of a refresh though). You know what, you can fly the 747-400 to Palma (BE QUICK, BEFORE THE 744 ERA ENDS).We mentioned (and promised to link) those two:The worst airport in the world (by Jo Ellison, in the FT, paywall possible, I'M SORRY, JO, FOR MISNAMING YOUR LAST NAME!!!!), andThe DISGRACEFUL State of British Airways (by Nonstop Dan, on YouTube).See you again for 127, and, in the meanwhile, please give us any feedback on Twitter or Instagram  (and Apple Podcasts if you're inclined to give us a nice review).

Programa La Hora de la República (LHR) del martes 13 de diciembre de 2022, emitido desde Radio Rebelde Republicana (RRR), junto a nuestra programación habitual, Comentario, Efemérides, dedicada a Dolores Ibárruri “Pasionaria”. En el nuevo espacio A fondo, en el que analizamos los hechos con sobriedad y rigor periodístico como es norma en LHR. Hablamos con el profesor XABIER ARRIZABALO MONTORO, que se define como marxista, militante obrero y delegado sindical. Trabaja como profesor de “Crítica de la economía política” en la Universidad Complutense de Madrid (UCM). Es Licenciado en Economía (1989), Licenciado en Sociología (1992) y Doctor en Economía Internacional y Desarrollo (1993), Autor de varios libros, y ha trabajado en decenas de universidades de los cinco continentes, sobre todo en América Latina. Tras están interesante charla, continuamos con el Análisis Político, los Valores Republicanos, El Rincón Poético y nuestro Epílogo. Y pondremos fin a nuestra andadura en 2022. En el estudio estaremos Ángel Pasero, Juanjo Picó y Enriqueta de la Cruz. Y como siempre en la zona técnica con gran maestría, tenemos a Patxi. No te pierdas el espacio LHR y toda la programación de RRR

En la programación de La Hora da La República desde Radio Rebelde Republicana del 06 de diciembre, además de nuestros espacios habituales; Editorial, Efemérides, Valores Republicanos, Rincón Poético y el Epílogo, en el espacio A fondo donde analizamos los hechos con sobriedad y rigor periodístico como es norma en LHR. Contamos hoy con MIRTA NÚÑEZ DÍAZ-BALART. Periodista y escritora. Profesora titular en el Departamento de Historia de la Comunicación Social, en la Universidad Complutense de Madrid (UCM), del cual es la actual directora. También fue directora de la Cátedra de Memoria Histórica de la Universidad Complutense de Madrid (UCM). También, en LHR del 06 de diciembre, tenemos la Crónica desde la tercera capital de la II República, por nuestro corresponsal en Barcelona, JOAQUÍN SOLER CURA. Hacemos este programa desde el estudio, Ángel Pasero, Juanjo Picó y la colaboración especial de Enriqueta de la Cruz, periodista y escritora y en la zona técnica desde Pamplona, tenemos a Patxi. No os perdáis LHR ni la programación de RRR

Nuevo programa de La Hora de la República (LHR), desde Radio Rebelde Republicana (RRR) en la web y la aplicación, martes 29 de noviembre de 2022, de 19 a 20 horas. LHR, como una ventana abierta al periodismo riguroso, comprometido con la verdad informativa dando voz a quienes se la niegan en los medios convencionales al servicio del poder económico y político. Junto a nuestros espacios habituales, Editorial, Efemérides, Actualidad Política, Valores Republicanos, Rincón Poético, el Epilogo y las crónicas de nuestros/as corresponsales en diferentes ciudades, hoy tenemos una nueva entrega de nuestro nuevo espacio A fondo en el que dinamizamos la cultura, la creación informativa, analizando como es habitual en LHR, los hechos sin estridencias, con sobriedad e ironía cuando hace falta y con mucho sentido crítico. Hoy en A fondo, contamos con la presencia a través de la ondas de Rosa San Segundo, catedrática en la Universidad Carlos III de Madrid, y Presidenta de la Plataforma Universitaria de Estudios Feministas y de Género (EUFEM). El equipo habitual de LHR, está formado por Patxi en la zona técnica de Radio Rebelde Republicana (RRR) en Pamplona, Ángel Pasero y Juanjo Picó en el estudio y en esta temporada contamos con la incorporación de Enriqueta de la Cruz, periodista y escritora. Os esperamos a todas/os en LHR.

Tras un paréntesis algo más que veraniego, en el que hemos recargado las pilas, vuelve LHR, desde Radio Rebelde Republicana (RRR), el 22 de noviembre de 2022, como una ventana abierta al periodismo riguroso, comprometido con la verdad informativa dando voz a quienes se la niegan en los medios convencionales al servicio del poder económico y político. En esta etapa que iniciamos además de nuestras secciones habituales, Editorial, Efemérides/obituarios, Actualidad Política, nuestros corresponsales en diferentes ciudades, los Valores Republicanos el Rincón poético, el Epílogo…, inauguramos el espacio A fondo en el que dinamizamos la cultura, la creación informativa, analizando como es habitual en LHR, los hechos sin estridencias, con sobriedad e ironía cuando hace falta y con mucho sentido crítico. En nuestra primera entrega de A fondo, contamos con la presencia a través de las ondas con el escritor y profesor de la Universidad Complutense de Madrid (UCM) ARMANDO FERNÁNDEZ STEINKO, con quién charlaremos sobre la actualidad política nacional e internacional. El equipo habitual de LHR, está formado por Patxi en la zona técnica de Radio Rebelde Republicana (RRR) en Pamplona, Ángel Pasero y Juanjo Picó en el estudio y en esta temporada contamos con la colaboración de Enriqueta de la Cruz, periodista y escritora.

In this episode Jay and I talk about talk about showing up as who you are. Struggles with the culture in Hollywood. Building on others success. Jackie Robinson and Junior, his inner bully. We also have a tech fail about 20 min into the podcast. Jay Andrews is a recognized expert in social media branding and personal resilience. He is the founder of RippleEffect which helps small businesses and entrepreneurs build values-based, authentic brands that align with the soul of their business. He also helps clients define and grow their social media presence to increase their lead generation and sales. In addition to running his company, Jay works as the Chief Business Officer at LHR, an international coaching and training company. Over the course of 3 years, Jay has developed the presence of the CEO and founder of the company on all social platforms earning her international recognition. With over 25 years of experience in the corporate and entrepreneurial fields and a proven track record of successful social media/branding campaigns, Jay continually finds time to spend with his partner and 4 teenage boys. Whether that's doing numerous activities outside, spending time a the lake, or cooking gourmet meals. In closing, Jay's personal mantra and professional mission statement are the same – to ”positively affect one person a day '.

We're semi-unplugged this week with Doug taping with his cellphone from a layover hotel room. Forgive us for too much realness on this MacGyver'ed episode. Drew gives an update on private pilot training and Doug is back from a 2nd LHR trip. We discuss what rights you have when your flight cancels. Surprise, you will get less from ULCC's (ultra low cost carriers). The DOT hss created a dashboard to help you fund the answers at:Customer Sevice Dashboard Other topics on this episode:Lufthansa avoids a pilot strikeCathay Pacific is hiring againUS airline traffic is back to pre-Covid levels while China struggles with lockdowns Descending into London, quietly, using CDAWe end the show with  listener comments regarding last week's discussion on the Flight 1's around the world.https://www.nexttripnetwork.com/

Doug has the smoothest flight ever to Eefrow (London Heathrow) and Drew is planning to fill in as ops manager at SFO where his airline career started. Doug's flight from SFO to LHR carries the legacy of Pan Am flight 1 which flew the route in the 90's. Pan Am flight 1 of yore flew around the world in 1947. We discuss the other “Flight 1's” of the world which represent several airline's most prestigious routes. Also on the episode:United and Emirates plan a possible codeshare agreement Italy's ITA gets bought out by an Air France/Delta and a private equity firmA Cessna 172 flew from California to Honolulu nonstopChina Airlines orders the Boeing 787 for the first timeWe finish the episode with a go-around on why most airliners are low wing and we share listener comments and questions. https://www.nexttripnetwork.com/

Doug embarks on his Atlantic IOE with a flight to Frankfurt that is pure aviation magic from two sunsets, during takeoff, and a rare view of the aurora borealis on a summertime flight. Drew might be changing from Team Piper to Team Cessna with a new instructor and flight school. A Cessna with a low budget “EICAS” system…whaaat? Also:In-class vs. in-the-field training787 deliveries are starting up againForget hate-selling, BA is “not-selling” tickets on LHR short haulFAA asks for public comment on airline seat sizeWe end with listener question what to where inflight in case of an emergency. Our answers may shock you. Join the conversation! 

In this episode of Line Up & Wait: USDOT investigating airlines not issuing refunds for cancelled flights: What is being done about it? What are the criterias for receiving a refund for a flight? What is going to be done for future cancellations? London Heathrow limiting travelers: Why is LHR capping traveler counts? Is this the right move? What does this mean for traveling during busy times? Iceland Air combats crew shortages at Amsterdam Schipol: What are they doing? Is this effective? Is there a profit to this tactice? Good idea? [Hosts: Jarid and Evan] (Recorded on 7/14/2022) (Published on 7/26/2022) Discord: https://discord.gg/927aYVTJSt Instragram and Twitter: LUAW_Podcast Facebook: Line Up & Wait Podcast info@luawpodcast.org --- Support this podcast: https://anchor.fm/luawpodcast/support

Linking the Travel Industry is a business travel podcast where we review the top travel industry stories that are posted on LinkedIn by LinkedIn members.  We curate the top posts and discuss with them with travel industry veterans in a live session with real audience members.  You can join the live recording session by visiting BusinessTravel360.com and registering for the next event.  Your Hosts are Riaan van Schoor, Ann Cederhall and Aash Shravah.Stories covered on this session include -Norse Atlantic Airways decides to enter the GDS distribution chain in a deal with WorldTicket, and Adrian Keating's post about this raises a few eyebrows with his choice of words: https://lnkd.in/dzrppqKiHeathrow introduces a cap on flights to try and match the limited resources now in place at the airport. It backfires on them massively, especially with the very short notice period of 36 hours to airlines. Harvey L. sums it up in two words here: https://lnkd.in/d4riG88XEmirates took the fight public and said "they refuse" to comply with this request, especially at such short notice. Many people posted about this including Tony Anderson from easyGroup, saying this is unlikely to end well. https://lnkd.in/dNkmBm_hDelta Air Lines had to take the extreme step of flying an empty plane to LHR simply to collect left behind luggage. Kevin Coffey tells us more about this here: https://lnkd.in/dq3GQTT6The airport disruptions are in other European hubs as well, and Icelandair is reportedly flying their own baggage handlers on some of their flights now! https://lnkd.in/dyEhrteCVirgin Atlantic finally producing a new premier product - the Retreat. Here's Shashank's take on it. https://lnkd.in/d_TwWdbqLufthansa announces GDS fees that will differ per GDS. Seems cheapest on Amadeus and most expensive on Travelport. Felix Dannegger asks if this is how GDS distribution starts crumbling. https://lnkd.in/dZE8Y4pZTune in every week to get your weekly update.  You can subscribe to this podcast by searching BusinessTravel360 on Google Podcast, Apple Podcast, iHeart, Pandora or Spotify. Support the show

Programa La Hora de la República (LHR), patrocinado por Unidad Cívica por la República (UCR), martes 28 de junio que emitimos desde Radio Rebelde Republicana (RRR), en Pamplona. Con Ángel Pasero, al micrófono y Patxi, en la zona técnica. Junto a nuestros espacios habituales, hoy hablamos con Fernando Trujillo, trabajador de ZUMOSOL, que al igual que sus compañeros llevan desde diciembre de 2021, encerrados en la factoría de cítricos en Palma del Río (Córdoba), en defensa de sus puestos de trabajo, que acumulan más de un año de nóminas impagadas a los casi 40 trabajadores de la plantilla. Zumosol, fue vendida al holding empresarial turco Toksöz, la empresa “pantalla” Cegeplas, según denuncian los trabajadores, adquirió la fábrica presuntamente sin otra intención que cerrarla varios días después y así no tener que pagar a los empleados ni indemnización por despido ni las nóminas atrasadas por la anterior propietaria, el holding empresarial turco llamado Grupo Toksöz. Seguimos con una entrevista a Carlos Sánchez Mato, por nuestro compañero, corresponsal en Barcelona Joaquín Soler Cura, quién a su vez, no ofrece su crónica desde la tercera capital de la II República. Los Valores Republicanos, el Rincón Poético y el Epílogo, configuran LHR.

Programa La Hora de la República (LHR), martes 21 de junio, en directo desde las 19 a 20 horas, en Radio Rebelde Republicana. Con Ángel Pasero en el estudio y Patxi, en la zona técnica. Junto a nuestros espacios habituales, hoy comentamos el resultado de las elecciones en Colombia que vive momentos históricos, ya que por primera vez la izquierda gana las elecciones y Gustavo Petro y Francia Márquez Mina, acceden a la Presidencia y Vicepresidencia en Colombia. Con el 51,47% de los votos, por delante del ultraderechista Rodolfo Hernández que alcanzó el 47,27%. Para comentar este importante acontecimiento, hablamos en directo cuando son las 14 horas en Colombia y las 19 en España con DEISY APARICIO JUCO, Líder juvenil miembro del Comité Ejecutivo Central de la Juventud Comunista Colombiana y Vicepresidenta del Consejo Nacional de la Paz. Nuestro análisis de la actualidad política, los Valores Republicanos, el Rincón Poético y el Epílogo, pone punto final a nuestro programa de LHR. Prohibida la extracción total o parcial de los audios y videos de Radio Rebelde Republicana en cualquier otro medio privado o público, sin nuestra autorización expresa por escrito.

Martes 14 de junio de 19 a 20 horas, desde Radio Rebelde Republicana (RRR), emitimos en directo La Hora de la República (LHR), patrocinado por Unidad Cívica por la República (UCR), con Ángel Pasero en el estudio y Patxi en la zona técnica. Abrimos con nuestro Comentario editorial. Continuamos resaltado el 91º de las elecciones a Cortes Constituyentes de donde salió la Constitución de la II República. Cerca de 600 mil personas, mayoritariamente mujeres trabajan en España como empleadas de hogar, -de las cuales, unas 200 mil, son migrantes en sin papeles-, en condiciones de precariedad, sin derechos básicos como es el seguro de desempleo, con jornadas interminables. De todo esto hablamos con ROMMY ARCE LÉGUA. Exconcejala de Ahora Madrid (2015-2019), en el ayuntamiento de Madrid, que está implicada junto a las trabajadoras de hogar, para que a éstas, les sean reconocidos sus derechos laborales según el convenio 189 de la Organización Internacional del Trabajo (OIT) que España ha tardado 12 años en ratificar. La actualidad política, los Valores Republicanos, el Rincón Poético y nuestro Epílogo, ponen el punto y final a nuestro programa de hoy. Te recomendamos sigas LHR y toda la programación de RRR

Martes 24 de mayo, de 19 a 20 horas, vuelve tras un breve paréntesis a Radio Rebelde Republicana (RRR), La Hora de la República (LHR), patrocinada por Unidad Cívica por la República (UCR). Tras el comentario editorial, conmemoramos el obituario de un luchador Ricardo Maya, uno de los muchos héroes anónimos que pelearon por una mejor calidad de vida y derechos democráticos, su hija Rosa Maya, estará en nuestra antena. Continuamos hablando con MARTÍN ZABALZA ARREGUI, Director General de Paz, Convivencia y Derechos Humanos del Gobierno de Navarra. Entre otros asuntos importantes, comentaremos el 84º Aniversario de la fuga de presos republicanos del Fuerte de San Cristóbal. Después abordaremos en Actualidad Política, la cumbre de la OTAN a celebrar en Madrid a finales del mes de junio. Los Valores Republicanos, el Rincón Poético y el Epílogo, ponen punto final a nuestra emisión del martes 24 de mayo de 2022. No te pierdas LHR ni toda la programación de RRR.

Mientras se anuncia el regreso a España de Juan Carlos I tras dos años en Dubái… Hablamos con la periodista ANA PARDO DE VERA, sobre su libro La armadura del rey. Un retrato del reinado de Juan Carlos I -Un libro escrito a partir de una profusa documentación y más de cien entrevistas a personalidades de todas las instancias del poder, pasado y actual. Ana Pardo de Vera: La coraza del rey, se empezó a forjar desde antes de empezar su reinado. Una coraza que le sitúa como puntal de régimen del 78, con la colaboración muy importante de Felipe González y Santiago Carrillo. El emérito vuelve a España como si no hubieran existieran las revelaciones de cuentas offshore, tarjetas black, chantajes, comisiones e investigaciones judiciales a nivel internacional. Ana Pardo de Vera: Felipe VI, gobierna para una parte de la ciudadanía española, como quedó patente en su discurso del tres de octubre de 2017. La reina Letizia, todo su empeño es ver reinar a su hija Leonor. Es urgente la reforma de la Ley de Secretos Oficiales que fue aprobada por el Congreso en junio de 2020. Esta es una ley franquista de 1968, y sepamos qué pasó el 23 F y cual fue el papel de Juan Carlos I. Ana Pardo de Vera: Juan Carlo I, traicionó a su padre y después a Franco, ya que ante éste juró los Principios del Movimiento, que luego ignoró, ante la presión de dar una nueva imagen. Ángel Pasero por LHR. Patxi, en el área técnica de RRR. Prohibida la extracción total o parcial de los audios de Radio Rebelde Republicana en cualquier otro medio privado o público, sin nuestra autorización expresa por escrito.

This week, we kick off the show with an interview featuring Fleming Shi, where we discuss Destructive Malware and Other Threats to Watch! Then, in the Security News: Colonial Pipeline facing $1,000,000 fine, cybercrime tracking bill signed into law, Lincoln College Set to Close After Crippling Cyberattack, Nvidia's LHR limiter bypassed, & North Carolina Becomes the First State to Prohibit Public Entities from Paying Ransoms, & more! This segment is sponsored by Barracuda Networks. Visit https://securityweekly.com/barracuda to learn more about them! Visit https://securityweekly.com/acm to sign up for a demo or buy our AI Hunter! Follow us on Twitter: https://www.twitter.com/securityweekly Like us on Facebook: https://www.facebook.com/secweekly Visit https://www.securityweekly.com/psw for all the latest episodes! Show Notes: https://securityweekly.com/psw740

In the Security News for this week: Colonial Pipeline facing $1,000,000 fine, cybercrime tracking bill signed into law, Lincoln College Set to Close After Crippling Cyberattack, Nvidia's LHR limiter bypassed, & North Carolina Becomes the First State to Prohibit Public Entities from Paying Ransoms!   Visit https://www.securityweekly.com/psw for all the latest episodes! Show Notes: https://securityweekly.com/psw740

This week, we kick off the show with an interview featuring Fleming Shi, where we discuss Destructive Malware and Other Threats to Watch! Then, in the Security News: Colonial Pipeline facing $1,000,000 fine, cybercrime tracking bill signed into law, Lincoln College Set to Close After Crippling Cyberattack, Nvidia's LHR limiter bypassed, & North Carolina Becomes the First State to Prohibit Public Entities from Paying Ransoms, & more! This segment is sponsored by Barracuda Networks. Visit https://securityweekly.com/barracuda to learn more about them! Visit https://securityweekly.com/acm to sign up for a demo or buy our AI Hunter! Follow us on Twitter: https://www.twitter.com/securityweekly Like us on Facebook: https://www.facebook.com/secweekly Visit https://www.securityweekly.com/psw for all the latest episodes! Show Notes: https://securityweekly.com/psw740

0:00 Colton got fired for doing science 0:21 Google I/O 2022 2:04 RX 6950 XT 2:49 Intel 12th Gen HX series chips 3:46 Mine 4:29 QUICK BITS 4:36 100% LHR limiter unlocked 5:15 iPod discontinued 5:41 Match Group sues Google 6:05 Tesla "recalls" 130K vehicles 6:30 Crypto crash News Sources: https://lmg.gg/wYzr8

In the Security News for this week: Colonial Pipeline facing $1,000,000 fine, cybercrime tracking bill signed into law, Lincoln College Set to Close After Crippling Cyberattack, Nvidia's LHR limiter bypassed, & North Carolina Becomes the First State to Prohibit Public Entities from Paying Ransoms!   Visit https://www.securityweekly.com/psw for all the latest episodes! Show Notes: https://securityweekly.com/psw740

**This podcast was recorded using Russian Zoom, which is better than regular Zoom, which is now forbidden by the way**On this episode of real audio collected by FSB and CIA triple agents then sent to LHR for comedy purposes, a certain "great leader" wishes to know the status of his secret underground luxury bunker.Performed by David Bluvband, Adam Bozarth, and Anna RubanovaSupport LHR by joining our Patreon at patreon.com/lefthandedradio or leave a 5-star rating and review wherever you subscribe to our show. Seriously.http://www.lefthandedradio.com/merchLeftHandedRadio.com | patreon.com/LeftHandedRadio | http://twitch.tv/lefthandedradio | facebook.com/LeftHandedRadio | instagram.com/lefthandedradio | twitter.com/LeftHandedRadio| lefthandedradio@gmail.com | https://www.tiktok.com/@lefthandedradioSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A new way to bypass Nvidia's LHR system to restrict Ethereum has been reportedly bypassed... except it's a clever trap. let's talk about it. --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/earlybirbbriefing/message Support this podcast: https://anchor.fm/earlybirbbriefing/support

Nvidia hoped to save the GPU shortage with the launch of the LHR system to lower the mining capability. But how well did it actually work? Let's talk about it. --- Send in a voice message: https://anchor.fm/earlybirbbriefing/message Support this podcast: https://anchor.fm/earlybirbbriefing/support

This is a continuation of the dialogue between the guests from Episode 10 except guest Freshta Karimi could not join us and Ilaha Eli Omar, Founder and Director of Uplift Afghanistan joins to offer more perspective of the humanitarian crisis on the ground following the withdrawl at the end of August 2021 by the United States government.  This episode explores more about the legal, humanitarian and human rights issues facing Afghanistan, its people and the growing Afghani diaspora following the events of 2021.   In this episode we discuss: The current state of the humanitarian crisis on the ground in December 2021 The legal and media response of the world community The feelings of abandonment by the world community that some Afghans are feeling as this crisis starts to fade from the top of news cycles The United States government creation of special visas for certain Afghans as well as humanitarian parole  The failing thusfar by the United States to offer protection to Afghan citizens in need of an escape route Contrasting the United States vs. Canadian response and resettlement by Canada Farnoosh and Ilaha discuss their work together in Afghanistan  What can people do and where can they give to aid the effort    These are the sources recommended by our guests for giving or volunteer efforts: 1)  Uplift Afghanistan (Guest Ilaha Eli Omar is the Founder and Director)  http://www.upliftafghanistan.org 2)   Lifeline Afghanistan (in Canada)   http://www.lifelineafghanistan.ca 3) Afghan  American Artists and Writers Association  http:///www.aaawa.net 4) Afghan Legal Empowerment Portal (Guest Farnoosh Hashemian is a co-founder of this resource)  BIOGRAPHIES FARNOOSH HASHEMIAN Farnoosh Hashemian is an Iranian-American human rights lawyer with over two decades of experience advancing rights and dignity of vulnerable people around the globe. Notably, in 2011, she worked with Afghanistan Independent Human Rights Commission on security sector reform and from 2014-2018 she led and provided technical support to an Afghan coalition of prominent criminal justice reform groups and government officials, to draft and pass, the country's groundbreaking anti-torture legislation. She is currently the Acting Director for Law Exchange with the Open Society Foundations' Public Health Program, where she works on legal empowerment initiatives that improve health justice for marginalized groups. Since the beginning of the crisis, and in her personal capacity, she has co-led Afghan Legal Empowerment Portal, aiming to secure a safe right of passage for all Afghan grassroots activists left behind. Throughout her career, Farnoosh has sought to honor the work of justice defenders who came before her, build on collective local wisdom, and do the deliberate and careful intersectional work in pursuit of gender justice. In her view, it is indeed a feminist's job to counter the alarming overuse of policing, surveillance, detention, and oppressive measures that replicate in the war on terror, the war on drugs, and the war against migrants. H HASHEMIAN   RANA HAZARAT Rana Hazarat is an Afghan-Canadian human rights lawyer based in Vancouver, BC. She arrived with her family to Canada as refugees. She is of Tajik and Hazara descent. Her lived experience as a refugee impacted her desire to pursue a legal education. Rana studied Political Science and Economics at the University of British Columbia and obtained a Juris Doctor from the Peter A. Allard School of Law. I currently work for Lawyers for Human Rights as a legal intern, which is funded by the Canadian Bar Association and Global Affairs Canada. She works with LHR's Refugee and Migrant Rights Programme. She  is also working on several national and international initiatives in response to the humanitarian crisis in Afghanistan, such as assisting with the resettlement of Afghans in Canada, facilitating refugee sponsorship applications, and drafting public legal education materials, calls to actions, and policy papers.  You can reach Rana by contacting the podcast if you have questions or a message for her.    ILAHA ELI OMAR Ilaha Eli Omar is an Afghan-American grassroots mobilizer with over 20 years of international development work and on-the-ground experience in Afghanistan, Haiti, and Kenya. Using her experience as an entrepreneur and founder of a successful technical consulting company, Ilaha enables nonprofits to transition from donor-dependent to self-sustainable organizations. In addition, Ilaha is currently a board and advisory council member for several nonprofits that focus on poverty alleviation, disability rights, emergency aid, and access to healthcare and education for all in Afghanistan, Haiti, and Kenya. Recently Ilaha launched Uplift Afghanistan Fund, a charitable fund aimed at connecting impact-driven donors with grassroots and community-led initiatives in Afghanistan. Ilaha holds a Global MBA from Thunderbird School of Global Management, is a member of the US-Afghan Women's Council, and is currently based in San Francisco, California.  JESSICA SMITH BOBADILLA Please find Jessica Smith Bobadilla's bio at her website attorneyjessica.com.  Please follow the podcast on Apple Podcasts, Spotify and Stitcher.  Look out for bilingual Spanish content soon for all our episodes as well as addition of the video to our Youtube channel, I Am Attorney Jessica, The Podcast.

In this episode Jessica is joined by Farnoosh Hashemian, Freshta Karimi, Rana Hazarat and Sahar Muradi to discuss the human rights dimensions of the issues facing Afghanistan in 2021.    In this episode we discuss: The impact of the United States withdrawing in August 2021 from Afghanistan  The reasons for the nature and timing of the United States withdrawing  after 20 years of engagement Different vulnerable groups impacted by the changes in the balance of power and takeover of the Taliban Life for Afghanis under the Taliban Sahar's work as an artist to enable Afghani artists to use their voices and to assist some in attempting to exit  the country so they can continue their work freely Rana's experience working as a Canadian human rights lawyer and with networks of people worldwide attempting to relocate Afghan refugees Frehta's recent journey out of Afghanistan to Canada with her family and the details of how she almost did not make it out despite having been granted visas to multiple countries Farnoosh's work to assist the human rights defenders still stuck in Afghanistan how are at risk with options for exiting the country Freshta's observations of the problems with how US programs and development were conducted in light of the recent withdrawl Fresha's grave concern for her fellow Afghanis  How you can help Afghani people and refugees: These are the sources recommended by our panel:   1) Uplift Afghanistan: http://www.upliftafghanistan.org   2) Lifeline Afghanistan: http://www.lifelineafghanistan.ca    3) Afghan American Artists and Writers Association: http:/www.aaawa.net BIOGRAPHIES  Farnoosh Hashemian is an Iranian-American human rights lawyer with over two decades of experience advancing the rights and dignity of vulnerable people around the globe. Notably, in 2011, she worked with Afghanistan Independent Human Rights Commission on security sector reform. From 2014-2018 she provided technical support to a coalition of prominent criminal justice reform groups and government officials, to draft and pass, Afghanistan's groundbreaking anti-torture legislation. She is currently the Acting Director for Law Exchange with the Open Society Foundations' Public Health Program, where she works on legal empowerment initiatives that improve health justice for marginalized groups. Since the beginning of the crisis, and in her personal capacity, she has co-led Afghan Legal Empowerment Portal, aiming to secure a safe right of passage for all Afghan grassroots activists.   Throughout her career, she has sought to honor the work of justice defenders who came before her, build on collective local wisdom, and do the deliberate and careful intersectional work in pursuit of gender justice. In her view, it is indeed a feminist's job to counter the alarming overuse of policing, surveillance, detention, and oppressive measures in the war on terror, the war on drugs, and the war on migrants.  Freshta Karimi is the Founder and Director of Da Qanoon Ghushtonky (DQG – “Seeker of Law” in Pashto), one of the largest legal aid service organizations in Afghanistan. Shereceived her Law degree in 2014 from Payam-e-Noor University in Kabul and she is currently studying her masters in Kabul in law and criminology.  Freshta Karimi has dedicated her career to improving access to justice and promoting women and children's rights since 2002. She is also a member of several groups advocating policy changes and has traveled extensively internationally representing her organization and promoting various women's rights issues and highlighting the concerns of Afghan women. As an activist from the ‘new generation' of Afghan women, Ms. Karimi has already affected change within her own organization and is committed to building a more secure and safe country for vulnerable groups. In addition to her commitment to combatting violence against women in Afghanistan, through her organization, Da Qanoon Ghushtonky (DQG), Ms. Karimi has worked to increase communities' legal public awareness at the district and provincial levels, utilizing the publication of a variety of popular legal awareness materials.   DQG currently provides legal aid services for women, children and men in criminal and family cases in 16 provinces of Afghanistan. From DQG's establishment in 2006 through March 2017, DQG lawyers have handled more than25,000 criminal and family cases, of which 70% of clients have been released or in civil cases, resolved in the favor of clients.  Moreover, DQG has worked consistently to build the capacity of defense lawyers, law and Sharia Law students, paralegals, judges, prosecutors and police over the past eight and half yearsthrough various training programmes. She has also frequently travel within Afghanistan, as part of her duties as Director of DQG.  She has also traveled internationally to represent both DQG and Afghan civil society. Recent travel has included trips to the India, Maldives, Belgium, United States, Germany, Spain, France, Denmark, Sweden and Hungary. In 2018 and 2016 she has also attended the Brussels and Geneva conferences and in 2014, she attended the London Conference on Afghanistan as the spokesperson on behalf of Afghan civil society. On many of these trips she has engaged the international media. Freshta received an award for her work from the Danish government.  She can be reached by email at freshta.karimi1@gmail.com.   Rana Hazarat is an Afghan-Canadian human rights lawyer based in Vancouver, BC. My family and I came to Canada as refugees. I am of Tajik and Hazara descent. My lived experience as a refugee has impacted my desire to pursue a legal education. I studied Political Science and Economics at the University of British Columbia and obtained a Juris Doctor from the Peter A. Allard School of Law. I currently work for Lawyers for Human Rights as a legal intern, which is funded by the Canadian Bar Association and Global Affairs Canada. I work in LHR's Refugee and Migrant Rights Programme. I am also working on several national and international initiatives in response to the humanitarian crisis in Afghanistan, such as assisting with the resettlement of Afghans in Canada, facilitating refugee sponsorship applications, and drafting public legal education materials, calls to actions, and policy papers.  She can be reached by email at ranahazarat@gmail.com    Sahar Muradi is a NYC-based writer, performer, and educator. She is the author of Ask Hafiz (which received the 2021 Patrons' Prize for Emerging Artists from Thornwillow Press), [ G A T E S ] (Black Lawrence Press), and A Garden Beyond My Hand (Belladonna*), as well as co-author of A Ritual in X Movements (Montez Press), and co-editor of One Story, Thirty Stories: An Anthology of Contemporary Afghan American Literature (University of Arkansas Press). She is a founding member of the Afghan American Artists and Writers Association, which has recently mobilized to respond to the current humanitarian crisis in Afghanistan through public education and advocacy, fundraising on behalf of at-risk Afghan artists and activists, assisting with evacuation and resettlement efforts, and facilitating visa and parole application filing. Sahar has an M.F.A. in poetry from Brooklyn College, an M.P.A. in international development from NYU, and a B.A. in creative writing from Hampshire College. She directs the arts education programs at the cultural equity organization City Lore and dearly believes in the bottom of the rice pot. More at saharmuradi.com.  

In this episode of Daily Crypto we discuss the recent behavior of Bitcoin, why it's peak then dropped, and why we might be on the verge of a historic bull run, plus one skeptic's thoughts of Bitcoin's true price, how miners are getting around graphic cards low hash rates, and a master art forger who is entering the NFT world.  Episode resources: Bitcoin Miners Send An Unusual Amount Of Coins To Exchanges Bitcoin bull run: analysts predict record rally to end 2021 Bitcoin price spikes 10% and surpasses $ 55,000 thanks to billionaire George Soros Bitcoin market capitalisation hits $1 trillion surpassing Facebook, Tesla Bitcoin is 'overpriced' as it is worth no more than $28k, says ByteTree's investment chief Crypto miners have busted through Nvidia's LHR graphics cards yet again Infamous German art forger Wolfgang Beltracchi is selling recreations of the world's most valuable painting as a collection of NFTs Blockchains vie for NFT market, but Ethereum still dominates — Report See omnystudio.com/listener for privacy information. --- Send in a voice message: https://podcasters.spotify.com/pod/show/cryptodailyshow/message

In this experience we look at seating configuration on aircraft in economy or coach class. These days, with the COVID-19 pandemic, people are wondering about seating and what it might look like in the future. We will still need to pick our seats. Vinod has great stress when he picks a seat – particularly on long-haul flights – checking all angles of what his seat experience will be. Seat comfort has come a long way – increasing seat comfort used to mean adding more padding. Geoff shares his experience sitting in an aircraft seat from a Lockheed Constellation...my how far we've come. Even though airplane manufacturers have a row plan dictating how seats are set out, the actual number of seats, seat pitch and cabin layout is up to the airline. Can low cost carriers add additional rows – Vinod shares a memory of going through this. What is seat pitch? What do you need to research when selecting a seat? Remember that even if the plane type is the same at an airline, it may not be configured the same way. What happens if the airline reduces the amount of premium cabin? Remember that if an airline is charging a premium for a seat selection, it might not be the best seat. We're not telling you what the best seat is, since we all have our own reasons. What's the most stable seat? Where's the galley...the lavatory? How narrow is your seat? Is your airline using festival-style seating? What are some strategies for festival-style seating airlines? What should you watch out for? Vinod shares a story how old-school thick foam padding protected him on a flight to London Heathrow. Vinod shares a story of getting moved a seat that would only recline on the way to AMS. Vinod shares a standby experience when he got a special seat. There is a tip on what to ask about if your flight is oversold or cancelled. Vinod shares another crazy story – this time with festival seating on a 777 from GRU to JFK. But sometimes flights are wide open – Geoff shares an experience from LHR to YYC where he had four seats to himself. News Items: Simple Flying article "IATA Head Says Social Distancing Will End Cheap Travel". Skift article "EasyJet May Ditch Middle Seats When Flights Return". Financial Times article "Ryanair will not return to flying if middle seats must be empty, says chief". Aviointeriors "Glassafe" and "Janus" seat designs. If you have a story about seating configuration on flights, a question, or other experience that you would like to share, please email us at stories(at)seat1a.org or find us on Facebook, Twitter, Instagram and Patreon. Show notes are available online at http://podcast.seat1a.org/

In this experience we celebrate the 2019 holiday season with a look at some of our crazy and (somewhat) horrific holiday travel stories. But first, Vinny and Geoff celebrate a milestone in this experience. This is the 25th show that they have done in tandem. Here's to the next 25 being just as fun of a ride. Vinny shares his incredible journey from CPH-LHR-AMS-JFK-YHM-YYC-YVR during a massive New Year's storm in YYZ. How many things can go wrong for Vinny on this flight? So many that we interject a couple of stories from Geoff along the way. Although Vinny's story is related to a standby experience, remember that you too could be affected by weather and become a standby passenger. Vinny starts his journey in CPH – it was just after New Year's – and world weather seemed normal, for now. He connects rather uneventfully to LHR and then AMS (little does he know what's coming). Flying standby on KLM he notices his flight options across Canada are quickly disappearing as there are no seats available. All US options were disappearing as well, except for JFK. So off to New York for Vinny. Geoff shares his experience when he caught the flu just before having to fly from VIE-DUS (don't worry we're just sharing the travel experience). He makes it to VIE and manages to catch his flight – but when he arrives in a delirious state to DUS, just how many times can he catch the wrong train? The next day he catches the correct train to FRA for a connection to YYC with Air Canada...all the while missing the massive 2013 Ice Storm that hit Toronto. He arrives in YYC - only to be subject to a medical check first implemented after the SARS epidemic. We return to Vinny who is now at JFK – but his bag isn't. The storm is brewing, and Vinny knows to get priority he needs to get to LGA. He learns about the "passenger rest area" at LGA – even with official blankets. He wakes up to find that LGA-YYZ flights are getting cancelled all over. But wait, there is a WestJet crew – maybe there's a chance? Disappointment awaits – how did the sand get in the engine? What hope is there left? Not much by air, the open road was the only thing left and there was some good fortune with rental costs. Just in time to drive through Manhattan at rush hour! Geoff shares another winter holiday travel delay experience yet again caused by a blizzard at YYZ. Conditions meant that the YUL-YOW-YEG ticket became a standby ticket, but only the YUL-YOW segment could be confirmed. Some t-shirts were traded for hotel and meal vouchers since he wasn't flying further that day. Eventually he got back to YEG with an upgrade to business class. The key lesson in the adventure is to be nice to front line staff...honey will get your further than vinegar – but make sure you know your cancellation or delay rights. We return to Vinny, in a rental car, in Manhattan at rush hour. No storm visible yet the sun is still shining. But as night falls the storm unleashes its fury. The storm is so terrible that it closes the Interstate. Vinny pushes on, blasting through the blizzard in Upstate New York on country roads – all the while having no proper winter clothing. Finally, he reaches the Canadian border in the wee hours of the morning – with snow caked on the back of his car – and the severity of the storm becomes fully known. Vinny has to get to another southern Ontario airport – YHM it is. But how to return the car – since it's not at YYZ and there is no return desk? Vinny leaves multiple notes and voicemails and parks the car hoping for the best as he boards the flight to connect at YYC. How does it turn out? Four hours after landing, where was Vinny? Back on a flight as crew! Lessons from the experience: 1) Keep moving forward; 2) figure out what your biggest block of problem could be; 3) Be prepared that it might cost a bit of money to get out of a jam; 4) Look for telltale signs of things that are happening; 5) Make sure you have all of your alerts set up...and check the weather. Oh, and by the way...what happened to Vinny's WS travel buddy? News Items: Flyertalk article "The Best and Worst Airports for Holiday Travel" breakingtravelnews article "Christmas getaway begins in earnest at easyJet" Vinny and Geoff give big kudos to crews and staff working over Christmas. Here's to another great 25 experiences together. If you have a holiday travel horror story, a question or other experience that you would like to share, please email us at stories(at)seat1a.org or find us on Facebook, Twitter, Instagram and Patreon. Show notes are available online at http://podcast.seat1a.org/ (Sleighbells sound FX from GowlerMusic edited and mixed with other sound FX https://creativecommons.org/licenses/by/3.0/)

Josue Pavon hosts The Garden Report and covers the Boston Celtics for CLNS Media. 1:20 LHR's worst Celtics prediction 7:39 How is Boston's D so good? 11:48 Gordon Hayward injury: A blessing in disguise 17:33 Josue's bold Jaylen Brown prediction 24:55 Kyrie Irving as favorite for NBA MVP 29:01 Why Cleveland Cavaliers will still win East Available for download on iTunes and Stitcher on Sunday, November 19th. Celtics Beat is presented by Bombfell & Harry's Razors.  Get a FREE TRIAL at harrys.com/celtics

LOST EPISODE RELEASE with instant reactions by LHR on original Isaiah Thomas & Jae Crowder for Isaiah Thomas trade with guest Chris Forsberg, who serves as the Boston Celtics beat reporter for ESPN. Twitter @ESPNForsberg   1:33 Most shocking trades in sports history 5:58 Reasons for/against trading Isaiah Thomas & Jae Crowder for Kyrie Irving 21:12 Celts no longer a lock for ECF? 28:35 Brad Stevens challenges w/ Boston's offense & defense 34:01 Russell Westbrook Theory for Kyrie   Available for download on iTunes and Stitcher on Thursday, August 31st. Celtics Beat is presented by FanDuel and Audible.  Get a free audiobook with a 30-day trial by signing up at www.audible.com/celticsbeat