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Testosterone levels in 40-year-old men are 30 percent lower than their fathers, and most doctors still have no idea what to do about it. -Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Justin Houman, a nationally recognized urologist and Assistant Professor of Urology at Cedars-Sinai Medical Center. Fellowship-trained and specializing in men's health, male fertility, and sexual medicine, Dr. Houman combines cutting-edge medical advancements with holistic lifestyle strategies to help men optimize testosterone, sexual health, and reproductive performance at every age. Together, Dave and Dr. Houman tear through the myths, the bad science, and the outdated medical dogma around testosterone, erectile function, fertility, and male sexual health. They cover everything from why testosterone levels have collapsed in a single generation, to the real story behind the FDA black box warning, to practical protocols for men who want to optimize without sacrificing fertility. This is the masterclass on men's health that no one else is having on record. This is essential listening for anyone serious about biohacking, longevity, human performance, hormone optimization, brain optimization, anti-aging, functional medicine, mitochondria, and Smarter Not Harder approaches to male health. You'll Learn: Why testosterone levels in 40-year-old men are 30 percent lower than their fathers and what is driving the collapse How low testosterone connects to anxiety, depression, high cholesterol, blood sugar dysregulation, and all-cause mortality risk The truth about the original testosterone and heart attack study and why it still has not been retracted How to preserve fertility while on TRT using Clomid, enclomiphene, and HCG Why daily low-dose Cialis is one of the cheapest and most effective longevity drugs available What shockwave therapy, PRP, exosomes, and Botox injections actually do for erectile function How red light therapy at 660 and 850 nanometers supports testosterone production and nocturnal erections The supplement stack including ashwagandha, tongkat ali, fadogia agrestis, and creatine that supports healthy hormone levels Why porn-induced ED is epidemic in young men and how to reverse it How PT-141 and peptides fit into a complete male optimization protocol Thank you to our sponsors! Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE.Establish a powerful foundation for sustained wellness with Pique. Unlock 20% off: piquelife.com/DAVE BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: testosterone, low testosterone, TRT, testosterone replacement therapy, male fertility, erectile dysfunction, ED, men's health, sexual health, hormone optimization, Dave Asprey, biohacking, longevity, anti-aging, human performance, Dr. Justin Houman, Cedars-Sinai, urologist, shockwave therapy, PRP, exosomes, Botox penis, red light therapy, nitric oxide, Cialis, tadalafil, Viagra, sildenafil, PT-141, Melanotan, peptides, ashwagandha, tongkat ali, fadogia agrestis, creatine, Danger Coffee, Smarter Not Harder, Kyzatrex, clomid, enclomiphene, HCG, prolactin, cabergoline, porn-induced ED, refractory period, fertility, sperm health, spermatogenesis, FSH, LH, estrogen, aromatization, functional medicine, supplements, mitochondria, circadian rhythm, sleep optimization, cortisol, microplastics, inflammation, cardiovascular health, dementia, all-cause mortality, nocturnal erections, penile health, male optimization Resources: • Learn More About Dr. Houman's Work At: https://houmanmd.com/ • Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey's BEYOND Conference: https://beyondconference.com • Dave Asprey's New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/ • Upgrade Labs: https://upgradelabs.com Timestamps: 00:00 – Introduction 01:15 – Low Testosterone Epidemic 04:23 – Ejaculation & Testosterone 07:30 – Refractory Period & Aging 09:58 – Porn-Induced ED 11:09 – Cabergoline & Prolactin Management 12:42 – Oral Testosterone 13:24 – Testosterone Target Levels 16:46 – Supplements for Testosterone 18:46 – Anxiety-Based ED 26:23 – Penis Enhancement Options 27:37 – Shockwave Therapy 28:57 – Cialis for Longevity 29:56 – Fat & Filler Injections 34:50 – Pre-Sex Optimization 40:13 – Red Light Therapy 42:18 – Heat & Cold for Testosterone 43:35 – Underwear & Microplastics 44:58 – Testosterone & Fertility 49:15 – HCG & Preserving Fertility 52:00 – Testosterone Dosing Timing 53:22 – Creatine & Mitochondrial Health 55:20 – Overtraining Effects 56:24 – Peptides (PT-141) 59:08 – Optimal Diet for Fertility See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

One-on-one pod today, Chris and Jason are back from Paris to chat about New York Sour Diesel, Uno at the dinner table, the Vince Staples Live Más experience, a listener plea regarding Viagra, which drugs work best, a recap of our Loewe show in Paris, Chris seeing Cat Power last night, giving the Harry record a little more time, René Redzepi serving body shots, and cameras in the pit. twitter.com/donetodeath twitter.com/themjeans howlonggone.com Learn more about your ad choices. Visit megaphone.fm/adchoices

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If your erections are changing, it may not be “just aging.” Rita De Michele sits down with Dr Arthur Burnett II, a Johns Hopkins urologist whose research helped make treatments like Viagra possible, to explain why erectile dysfunction can be an early signal of bigger health issues like cardiovascular disease and diabetes. They also unpack common testosterone misconceptions, when men should ask for PSA screening, and how modern prostate cancer care can protect long term sexual function. This is a practical, straight talking conversation to help men advocate for their health earlier, not later.

Dr. Deb Muth 0:00 Welcome back to Let’s Talk Wellness Now. I’m your host, Dr. Zab, and we are continuing our discussion this week on 0:08 peptides. And so, if you haven’t heard our first conversation about peptides, 0:13 please go back and look at that episode. We talk all about the manufacturing, the safety, the quality of peptides, and we 0:20 dove into GLP1s. And today we’re going to dive into peptides for sexual 0:26 wellness, immune function, growth hormone, and all the amazing fun things 0:32 we can do with peptides. So, as usual, grab your cup of coffee or tea, settle 0:37 in, and let’s talk wellness now. And we’re going to take a short pause from our sponsor. I know we’ve got to do 0:44 that, you guys. They’re who keep us on the air. So, I’m going to pause for just a minute and be right back after this 0:50 message from our sponsor. Ladies, it’s time to reignite your vitality. Primal 0:56 Queen supplements are clean, powerful formulas made for women like you who want balance, strength, and energy that 1:03 lasts. Get 25% off at primal queen.com. Serenity Health. That’s primalqueen.com. 1:10 Serenity Health. Because every queen deserves to feel in her prime. All 1:15 right, everybody. We are back. And are you ready? We are talking all things peptide and I am opening the show today 1:23 with sexual wellness. Yes, I’m going there, you guys. I am going there. You 1:29 know, this has really become a big issue for people um of all ages. It’s not just 1:3 4us older people. It’s younger people, too. And there’s a whole variety of reasons why we have sexual dysfunction. 1:42 And when we’re talking about sexual dysfunction, we’re not just talking about it doesn’t work, right? Or I can’t 1:48 reach orgasm. A lot of it is around desire and um the thought of it and 1:54 wanting to connect, wanting to be kinder to one another, wanting to be touching 2:00 one another. A lot of it resolves or revolves around that. And so there are some peptides that can help us and I’m 2:08 really excited to be able to talk about those today. So the first one is called PT-141. 2:14 This targets the brain not the periphery. Right? So for many women I 2:20 will always tell you sex starts between here. It is a brain thing for us. It is 2:26 not necessarily a physical thing. For guys that’s a little different. It’s very physical. For women it’s all in our 2:32 brain. So tip for you men that are listening. You have to prime your woman’s brain first if you want her to 2:38 have sex with you that night. You have to be nice to her. You have to bring her flowers. Do the dishes for her. Do 2:45 something kind. Bring her a cup of coffee or tea or a glass of wine. Take her to dinner. You have to woo her. And 2:51 I don’t care how long you’ve been married. That has to happen. And tip number two, don’t say anything stupid 2:57 that day. I’m just being honest. When you guys say things that make us upset, 3:03 that lingers with us for the rest of the day. And it’s it’s a turnoff for us. And 3:08 for a lot of women, we can’t get past that when it comes time to snuggle at night. And sex doesn’t always have to be 3:14 at night either. So, you can tell I really love talking about this conversation, but we’re going to get into the peptide part of it because this 3:21 is going to help people. So, um, PT-141 is marketed as I’m going to slaughter 3:28 this name, Vali, and it represents a fundamentally different approach to 3:34 sexual dysfunction than the PDE5s inhibitors like Slenden, Viagra, 3:40 Tedataphil, which is Seialis. And while the PDE5 inhibitors work specifically by 3:47 enhancing blood flow to the genital tissues, PT-141 works centrally in the brain by 3:54 modulating neural s neural circuits involved in the sexual desire and 4:00 arousal. Now PT-41 is a cyclic hpatipeptide. It’s seven amino acid 4:07 peptide arranged in a cyclic structure that acts as a melanoortin receptor 4:13 agonist and with particularly the infinity for MC3R and MC4R subtypes. 4:20 It’s actually a metabolite of the melanotan 2, a peptide originally 4:26 developed for tanning that was also found to enhance sexual desire in early 4:31 studies. Now the melanoortin system in the brain is involved in multiple functions including energy homeostasis 4:39 but it also is involved in sexual motivation and arousal behaviors. The FDA approved PT-141 in 2019 specifically 4:48 for the treatment of acquired generalized hypoactive sexual desire 4:54 HSDD in permenopausal women. So for the first time we have a medication that was 5:01 approved by the FDA to use for women for sexual dysfunction. We have had all of 5:07 these seialis tedataphil viagros for men but we had nothing for women. And so 5:12 this is amazing that this is available for women and approved by the FDA. It’s a big deal. This represents the first 5:19 and only FDA approved medication specifically targeting these circuits of sexual desire rather than the peripheral 5:27 arousal mechanisms. And this indication is quite specific, meaning it was developed at some point, not lifelong. 5:35 So I if you’ve had sexual dysfunction your entire life, this medication was 5:40 not approved for you. But if it’s something that you developed over time, like when you went through pmenopause or 5:46 menopause or some women have this experience happen after childirth, that’s what we’re talking about here. 5:53 Now, it’s also not just um supposed to be used if you dislike your partner, 5:59 right? If your relationship is bad and you dislike your partner, this probably isn’t going to fix a ton. It might help 6:05 a little bit, but that’s not what it’s meant for. So, you really have to know what you’re using it for and why. And 6:11 the other thing that I would say is this is something that we don’t go to if your hormones are not balanced properly. You 6:17 have to balance your hormones properly before using something like this because it still may not work. Now, the only 6:24 caveat to that is if you’re a woman that has a risk of breast cancer and can’t use hormones, then that’s a different 6:31 story and we would have that conversation about whether or not this medication would be appropriate for you. Now, the FDA label specifies PTA1 uh 6:39 PT-141 as it not being indicated for HSDD in causes where low sexual desire 6:46 is due to coexisting medical or psychiatric conditions, problems with relationships, like we had talked about, 6:53 side effects to medications or other substance use. This specifically reflects the importance of differential 6:59 diagnosis. Low sexual desire can have many root causes and PT-41 is only 7:05 appropriate when those causes have been ruled out. Now, I have I used PT41 in 7:10 people who have sexual dysfunction issues as a result of using 7:16 anti-depressants. Yes, I have. I’ve used Flynn in that effect as well. And it 7:21 does work sometimes, but it doesn’t work completely. But you need to know that that is not what the approval is for the 7:27 FDA. So that is done in something that we call off label use. So very important 7:33 to know. Now in these clinical trials leading to FDA approval, this was published by Kinsburg and colleagues in 7:40 obstetrics and gyne gynecology in 2019. PT-141 demonstrated statistically 7:46 significant improvements in sexual desire and decreases in distress related 7:51 to low desire compared to placebo. The effects manifest over 45 minutes to 7:56 several hours after the injection and the mechanisms involved modulation of dopamine and melanoorton pathways in the 8:04 hypothalamus and the brain regions that involved sexual motivation. Now cardiovascular effects of PT 141 require 8:12 careful attention. This drug causes transient increases in blood pressure about 3 to four points and transient 8:20 decreases in heart rate. And because of this, it is contraindicated in patients 8:25 with uncontrolled hypertension or known cardiovascular disease. And it has been studied in patients who’ve had recent 8:32 cardiovascular events or sorry hasn’t been studied hasn’t been studied in patients who’ve had recent 8:39 cardiovascular events. So patients need to have their blood pressures checked before starting therapy. Nausea is 8:45 extremely common. It is one of the biggest things I often will tell people to take an anti-nausea medicine if 8:52 they’re going to do this because the last thing you want to do is inject this medication and think it’s going to give 8:57 you this great time with your partner and you’re so nauseated that you can’t even perform, don’t want to kiss, don’t 9:05 want to do anything. It it can be pretty profound for some people. um it does affect about 40% of the patients in 9:12 clinical trials which is why many clinicians require or recommend an 9:17 anti-nausea medication like I had just said other common adverse effects include flushing injection site 9:24 reactions headache in about 13% of the population which I have seen worse if 9:30 people are prone to headaches and the headaches are pretty intense so I will also have them premedicate if they have 9:36 that um sensitivity ity with a Tylenol or Advil, Alie, whatever it is they 9:42 typically use for their headaches to help prevent that from occurring. Now, some patients also experience a 9:50 generalized hyperpigmentation of their skin, particularly in areas with chronic friction, and this may not be reversible 9:57 after discontinuation. So from an integrative perspective, PT-41 10:03 represents one tool in addressing female sexual dysfunction, but it should never be the first or only intervention. And 10:11 low sexual desire in women is complex. Multiffactorial involving hormonal imbalances, low testosterone, estrogen 10:18 deficiency, progesterone imbalances, thyroid dysfunction, adrenal dysfunction, and with elevated or 10:24 disregulated cortisol levels, sleep deprivation, relationship issues, unresolved trauma, including sexual 10:31 trauma, chronic pain, body image concerns, and medication side effects such as SSRIs are notorious for this. So 10:39 a comprehensive hormone panel including total and free testosterones, estradile, 10:45 progesterone, DHEA, thyroid function in cortisol assessment, ideally four-point 10:51 cortisol, salivary should precede any pharmacological intervention. And additionally, addressing the 10:57 psychological component and relationship dimensions through appropriate therapy is necessary. I have a lot of patients 11:03 that say, “This is just too much work for sex. I don’t want the side effects. I don’t want to deal with this.” and that’s totally fine. But for some 11:09 people, their sexual dysfunction is actually causing more problems on their 11:14 relationship and they want to do something to fix that. And just know that if you’re using a peptide like this 11:20 that comes with some of these side effects and you have to premedicate for it, it is not the end of the world. Um, 11:27 but it may be a possibility that you may need that. So, let’s dive into body composition and growth hormone access. 11:34 So Tesmarellin is the only FDA approved GH 11:40 analog. Tesarelin is marketed as Agrifta and Agria SV. It is a synthetic analog 11:48 of human growth hormone releasing hormone. So GH RH human growth hormone 11:53 releasing hormone. These things are such long names it’s confusing and it’s difficult to spit out, right? It 11:59 consists of 44 amino acids. The structure is identical to our own 12:05 body’s growth hormone GHR um with the addition of trans3 hexonol group which 12:14 stabilizes the molecule that extends its half-life compared to the native GHR. 12:19 The mechanism of tesmarellin is elegant in its preservation of physiological 12:24 growth hormone GH secretion patterns and rather than administering an exogenous 12:30 growth hormone directly, tesmarillin binds to the GH receptor in the anterior 12:36 pituitary gland stimulating the indogenous pulsatile release of GH. So 12:42 you know it it’s slower in that stimulation and it pulsates instead of a direct rise and fall. This pusile 12:49 pattern more closely mimics natural GH secretion which occurs in bursts 12:54 primarily during sleep. The GH then stimulates the liver to produce insulin-like growth factor IGF-1 which 13:01 exerts many of the downstream metabolic effects including lipolytic effects on 13:07 the atapost tissue. So fat atapose and how we break that down. The FDA approved 13:13 tesmarellin in 2010 for a very specific narrow indication, the reduction of 13:19 excess abdominal fat in HIV infected patients with lipodistrophe. This 13:25 condition characterized by abnormal fat redistribution with accumulation of visceral body fat and the loss of 13:32 subcutaneous fat in face and limbs developed as a complication of an 13:37 antiviral therapy particularly with older protease inhibitor reg uh 13:42 regimens. The visceral fat accumulation in patients is not just cosmetic. It’s associated with increased cardiovascular 13:49 risk, insulin resistance, and inflammatory markers. The pivotal trial that led to the FDA approval included 13:56 work by Stanley and colleagues published in the annuals of internal medicine in 2014. It demonstrated that tesmarillan 14:03 significantly reduced the visceral atapose measured by CT scan by approximately 15 to 20% which is a 14:10 significant difference to placebo over a short period of time only 26 weeks. Now, 14:16 interestingly, the total body uh weight typically remained stable or even 14:21 increased slightly as the reduction of visceral fat was sometimes offset by increases in lean body mass or 14:28 subcutaneous fat. This highlights an important point. Tesmearellin is not a weight loss drug in its conventional 14:34 sense. Its effects are specifically on body composition and fat redistribution. 14:40 Now the glucose metabolism effects of tesmarellin do require careful monitoring because GH and IGF1 can 14:47 induce insulin resistance. Tesmearellin can increase glucose levels and hemoglobin A1C and in these clinical 14:54 trials glucose tolerance and new onset diabetes occurred in some patients. So 14:59 this creates a therapeutic paradox while res reducing visceral fat we should theoretically improve metabolic health. 15:07 The GH mediated insulin resistance can worsen the glycemic control and patients 15:12 with diabetes require particularly close monitoring. The potential need for adjustment in diabetic medications can 15:19 occur. So I already know what you guys are thinking. Can I use Tesmarellin and 15:24 GLP1 at the same time? And the answer is yes. Especially in those people that we 15:30 know have an insulin resistance already or are prone to that, we can use lowd 15:36 dose micro doing GLP-1 along with tesmarellin to help prevent this from 15:42 occurring um or reduce the risk of it occurring. Now there are some other adverse related problems to growth 15:49 hormone access which include fluid retention which can uh manifest as uh 15:55 ankle swelling, joint pain, muscle pain, paristhesas, carpal tunnel syndrome is 16:01 common to see. Of course you can always see injection site reactions reported about 26 to 30% of the time in the trial 16:08 participants. And this also theoretically has a concern about IGF-1 elevation potentially promoting 16:14 malignancy through long-term data is limited. So we have to be cautious about 16:20 this but it is a growth hormone and anything that is a growth hormone can cause cells to grow and it cannot 16:26 necessarily differentiate between healthy cells and bad cells. So the drug is contraindicated is contraindicated in 16:33 patients with active cancer and in patients with the disruption of the HPA access from conditions like pituitary 16:40 tumors, pituitary surgery, head of radiation um and traumatic brain injury. 16:46 Now off label use of tesmarellin for general anti-aging or body composition 16:51 optimization in non-HIV population, it doesn’t have FDA approval. There is no 16:58 FDA studies. um that promote this, but practitioners do prescribe it for these 17:04 purposes under an experimental and not supported by FDA approved indications. 17:10 And um from an integrative medical standpoint, optimizing natural growth 17:15 hormone secretion through lifestyle interventions, high quality sleep is important. GH primarily is excreted 17:22 during sleep and deep sleep waves. So improving your deep sleep is important. Intermittent fasting can also increase 17:28 growth hormone by five-fold as demonstrated in a Hartman and colleagues uh study from the journal of clinical 17:35 endocrinology and metabolism in 1992. And highintensity interval training, adequate dietary protein, blood sugar 17:42 control, these all can help naturally increase your growth hormone. So, let’s 17:47 dive in now and talk about bone health. peptide hormones um such as oh I’m gonna 17:54 I’m gonna really slaughter this name. Terraparatide is a true bonebuilding 18:01 peptide. It’s marketed as forio. It’s a recumbent form of the first 34 amino 18:08 acids out of 85 of the human parathyroid hormone PTH. It represents a unique 18:13 approach to osteoporosis treatment because it’s one of the few truly anabolic anabolic bone therapies meaning 18:21 it actively binds new bone rather than simply preventing bone loss. The biology 18:26 of parathyroid is fascinating and seemly contraindicated or uh contradictory. 18:32 Continuously sustained elevations of PTH as occurs in hyperarathyroidism 18:37 is catabolic to bone. So people who have hyperarothyroidism typically have significant bone loss 18:44 especially before it’s diagnosed and it causes causes increased bone 18:49 reabsorption loss of bone density increased fracture risk and however 18:55 intermittent exposure to PTH as achieved with once daily uh injections of forio 19:01 has the opposite effect. This intermittent exposure preferentially stimulates osteoblasts bone building 19:08 cells over osteoclasts bone reabsorbing cells and it leads to 19:13 the net bone formation. So terraparatide binds to the PTH receptors on 19:20 osteoblasts and renal tubular cells in bone. It increases the number of 19:25 activity of osteoblasts stimulating the differentiation of osteoblast precursor cells and may 19:32 reduce osteoblast apoptosis basically programmed cell death allowing this bone 19:37 building cell to work longer. The result is increased bone formation, improved bone architecture and tbacular 19:45 connectivity and ultimately increased bone mineral density um particularly in the hip and the spine which is so 19:51 difficult to regain. The FDA approved this medication in 2002 based on pivotal 19:57 studies by Near and colleagues published in the New England Journal of Medicine in 2001 which demonstrated significant 20:05 reductions in vertebral and non-vebral fractures in post-menopausal women with 20:11 osteoporosis. specifically uh reduced new vertebral fractures by 20:17 65% and nonvettebral fragility fractures by 53% 20:23 compared to placebo over a median followup of 21 months. This is really 20:29 incredible because we have not seen this kind of um change uh in other 20:35 medications that we’ve used for osteoporosis. So current FDA approval 20:40 indicates uh this for post-menopausal women with osteoporosis at high risk for 20:46 fracture, men with primary or hypoconatal osteoporosis at high risk for fracture 20:53 and men and women with glucocord cord glucocordide 21:00 induced osteoporosis at high risk for fracture. The high risk qualifier is 21:05 important. uh terrapeptide is reserved for patients with severe osteoporosis, 21:11 multiple fractures, very low low bone density and those who have failed or are 21:16 intolerant of other therapies. The most significant concern for this medication 21:21 is highlighted in a boxed warning with rat toxicology studies where it caused 21:27 osteioaroma which is a bone cancer in a dose dependent and treatment duration dependent manner. The revolence of this 21:34 finding to humans is debated. Rats have fundamentally different bone biology than humans with continuous bone growth 21:41 throughout life and different PTH receptors. Now post marketing 21:46 surveillance in humans hasn’t shown a clear increase in osteocaroma risk but 21:51 theoretically concerns persist and because of this terapeptide is 21:57 contraindicated in patients at risk baseline risk for osteioaroma 22:02 including those with pageantss disease of the bone unexplained elevations of alkaline phosphate prior skeletal 22:10 radiations bone metastases or skeletal malignancies and pediatric patients or young adults 22:16 with open hyes. There’s also a lifetime treatment duration of only 2 years and 22:22 terrapeptide can cause transient hypercalcemia. So an elevated blood calcium and as PTH normally increases 22:31 calcium levels by enhancing bone reabsorption, increasing renal calcium 22:36 reabsorption and promoting activation of vitamin D which increases intestinal calcium absorption. Some patients 22:43 experience orthostatic hypotension within 4 hours of injecting requiring 22:48 caution in at risk populations for blood pressure. Common side effects include 22:53 muscle pain, joint pain, pain in the limbs, nausea, headache, and dizziness. So from an integrative bone health 23:00 perspective, terrapeptides should be part of a comprehensive strategy. Adequate calcium intake, 500 to a,000 23:08 milligrams of calcium a day from food and supplements combined. and vitamin D. 23:13 Getting vitamin D levels of at least 50 to 80 are essential for the drug to work 23:20 optimally. But beyond this, bone health requires vitamin K2, which directs calcium into the bones rather than soft 23:27 tissues, magnesium as a co-actor in bone metabolism, trace minerals like boron, 23:33 copper, silica, and of course, adequate protein intake, which many of us, especially as women, don’t do 0.8 8 to 1 23:42 gram of protein per kilogram of body weight, weightbearing exercise. Of 23:47 course, these all provide mechanical signals that complement the biochemical 23:52 symbol uh signals of terrapeptide. Sequential therapy is also critical. The 23:58 bone mass gains from terraparatide can be lost if patients don’t transition to 24:05 an anti-resorbbitive agent a bisphosphinate after completing this therapy and the anabolic effects to 24:12 build bone but maintaining the new bone requires preventing excess reabsorption. 24:18 So positive things about this but there are definitely some concerns as well. So 24:23 the next one we’re going to talk about is Lu Prolrooide. It is marketed under 24:29 the multiple brand names of Lupron, Depo, Eligard, and it’s a synthetic 24:34 nonapeptide analog of naturally occurring ginonadotropen releasing 24:39 hormone G&R, also called luteinizing hormone releasing hormone, LHR. 24:46 It’s a fascinating example of how manipulating natural hormonal feedback systems can create therapeutic effects. 24:53 So, G&RH is normally secreted in a pulsatile fashion by the hypothalamus 24:59 and travels to the anterior pituitary where it binds to G&R receptors and 25:05 stimulates the release of luteinizing hormone LH and follical stimulating hormone FSH. These ginatotropins signal 25:13 the ovaries or the testes to produce sex hormones, estrogen, progesterone in 25:18 women, testosterone in men. Uh, luoprololi lupron as a GNR agonist 25:26 initially mimics the action of natural G&R causing an acute flare response with 25:33 uh increased LHFSH secretion which temporarily increases sex hormone 25:38 production. However, the continuous administration which is in the depo 25:44 formulations, the GNR receptors in the pituitary become desensitized and 25:50 downregulated. And after about 2 to four weeks of continuous exposure, LH and FSH 25:56 secretion is profoundly suppressed, leading to what’s termed as chemical 26:01 castration. Testosterone levels in men drop to castrated levels less than 50 26:08 and estrogen production is marketkedly suppressed in women. This bifphasic 26:13 response creates both therapeutic applications and management challenges in prostate cancer where tumor growth is 26:20 typically androgen dependent and the ultimate goal is testosterone suppression. However, the initial 26:27 testosterone surge during the flare phase can temporarily worsen symptoms potentially causing increased bone pain, 26:34 urinary obstruction, or even spinal cord compression in patients with metastatic 26:40 disease. This is why uh luoprolide is often started with an anti-ad androgen 26:47 like bicladamide for the first two to four weeks to block the effects of the 26:52 testosterone surge. The FDA has approved lupalide for multiple indications across 26:59 formulations. In oncology, it’s used for palletive treatment of advanced prostate cancers. In gynecology, various 27:06 formulations are approved for endometriosis, for pain management and lesion reduction and for fibroids. 27:13 Typically for pre-operative uh hematological improvement in anemic patients. In pediatrics, it’s used for 27:20 central precocious p puberty basically to halt the premature sexual development of these young people. Now, there are 27:28 adex uh adverse effect profile that reflects profound hormonal suppression. 27:34 In men treated for prostate cancer, hot flashes affect about 59% of the patients. Other common effects include 27:41 general pain, swelling, bone pain. Um long-term use of these medications leads 27:47 to metabolic changes. It increases fat mass. It decreases lean mass. It worsens 27:53 insulin sensitivity, disrupts the cholesterol uh lipid panels, increases 27:59 diabetic risk, has some concerns over cardiovascular disease. And the metaanalysis have shown increased risks 28:06 of heart infarction, myocardial inffection, sudden cardiac death, and stroke in populations receiving 28:13 long-term androgen deprivation therapy. The bone effects are particularly dramatic. Without sex hormones, bone 28:20 density decreases significantly, typically 3 to 4% per year during the 28:26 first two to three years of therapy. And this bone loss may not fully be reversible after the the therapy 28:32 discontinues. The American Society of Clinical Oncology recommends bone density monitoring and consideration of 28:39 bisphosphinates uh in men receiving long-term androgen deprivation. In women treated for 28:46 endometriosis or fibroids, the estrogen suppression creates a hypoestrogenetic state similar 28:54 to menopause. Hot flashes affect 90% of patients with other common effects 29:00 including headaches, emotional irritability, decreased sex drive, vaginal dryness, bone density loss. And 29:08 because of these bone concerns and treatment duration with endometriosis, typically limited to six months, though 29:14 some formulations allow for longer use with adback hormonal therapy to 29:20 partially mitigate these side effects. The mood and cognitive effects can be s 29:25 significant. I’ve seen it over the years. the depression, the memory impairment, difficulty focusing and 29:31 concentrating. It can be very very traumatic and the quality of life that 29:37 happens for these uh women and men can be unbearing for many of them. Um, from 29:44 an integrative perspective, patients receiving this medication need comprehensive support care. Bone health 29:51 interventions using calcium, vitamin D, vitamin K2, weightbearing exercise, 29:58 cardiovascular risk management becomes critical, including blood pressure monitoring, lipid management, diabetes 30:05 screening. For hot flashes management, some patients respond to black coohos, 30:10 sage, or vitamin E. Though evidence is mixed and individual response varies, 30:16 omega-3s may help with the mood and the inflammation, resistance training becomes specifically important to 30:22 preserve lean muscle mass in the face of hormonal suppression. 30:27 Now there’s something called calcetonin salamon which is marketed as miaelin. 30:34 It is a nasal spray. It is now discontinued. And foral is the new 30:39 synthetic polyeptide hormone of 32 amino acids identical to calcetonin of salamon 30:47 origin. It represents an interesting case study in how initial promise gives 30:52 way to safety concerns that regulate a therapy to historical footnote status. 30:58 Calcetonin is naturally occurring hormone in humans. It’s secreted by the paraphalicular sea cells in the thyroid 31:04 gland. Its primary physiological role is to lower blood calcium levels by 31:10 directly inhibiting osteoclast activity, reducing bone reabsorption, increasing 31:16 renal calcium secretion or excretion, and possibly reducing the intestinal 31:21 calcium absorption. So, salamon calcetonin is used therapeutically because it’s more potent and longer 31:27 acting than human calcetonin. The FDA initially approved calceton and salmon 31:34 for several indications post-menopausal osteoporosis in women more than five 31:39 years post-menopausal when alternative treatments are not sustainable. Padet’s 31:44 disease for bone and hypercalcemium as emergency treatments. The nasal spray formulation is particularly popular for 31:53 osteoporosis because it offered a non-injectable alternative to bisphosphinates. 31:58 However, in 2012, the European Medicine’s Agency, EMA, conducted a 32:05 comprehensive safety safety review after a poolled analysis of 21 clinical trials 32:10 involving over 10,000 patients showed a statistically significant increase in 32:15 malignancy risk in patients treated with calceton salamon compared to compared to 32:21 placebo. The overall malignancy rate was 4.1% in calcetonin treated patients 32:28 versus 2.9% in placebo patients. The types of cancer 32:34 varied with no single cancer type predominating, making it difficult to establish a clear mechanistic link. 32:41 However, the signal was concerning enough that the EMA restricted the use of calcetonin containing medicines. In 32:48 the United States, the FDA issued communications about malignancy signal and conducted its own review. While they 32:56 didn’t fully withdraw the drug, the cons consensus shifted dramatically. The nasal spray formulations miaelson was 33:03 voluntarily discontinued by the manufacturer and current clinical practice guidelines now consider 33:10 calcetonin salamon as a second line or lower option for osteoporosis. While 33:15 behind bisphosphinates, dennism mob, uh, terrapeptide, the analesic effect of 33:21 calcetonin in bone pain, particularly in acute vitibbral, uh, compression 33:26 fractions from osteoporosis or pageantss disease may still provide a role for short-term use in these selected 33:32 patients. The mechanism of this pain relief is unclear, but may involve 33:38 effects of endorphin systems and/or direct actions on pathways. The history serves as an important reminder in 33:45 peptide medicine. Initial approval and early clinical use does not guarantee 33:50 long-term safety effects. Post marketing surveillance and poolled analysis of the clinical trial data can reveal adverse 33:58 effects that weren’t apparent in initial studies. It also underscores why newer 34:04 agents with better safety profiles um have largely replaced calcetonin in 34:10 clinical practice. So this is really an important thing. Not one thing stays the same forever. We have to change as we 34:18 identify new and better products as we identify problems and concerns. I will 34:24 always tell my patients if you are uncertain of taking a new drug which we 34:30 all should be wait five years. Within five years we are going to find the 34:36 problems that they didn’t find in the clinical studies. Remember, a lot of these clinical studies are small, small 34:43 groups, short periods of time. It’s expensive to do these trials. So, if you 34:49 wait for five years, in the first two to three years, you will see the problem start to emerge. And what are you going 34:55 to look for? You’re going to look for the the news um commercials from lawyers 35:02 suing a drug. And they will tell you what the problem is. and then you can decide, is this something that I want to 35:09 use or not. Don’t jump on bandwagon and be the first one to do this, especially 35:14 if you’re sensitive. You know, give it time so you can see exactly what’s going on. So, I’m going to end our show on 35:22 this and we are going to pick up on part three of peptide therapy in our next 35:28 segment where we’re going to talk about the investigational peptides and some 35:34 exciting things that are happening with that. So, I want to thank you for joining me today on Let’s Talk Wellness 35:39 Now. It’s always a pleasure having a conversation with you guys and I hope this brings value to you with what we’re 35:45 talking about. If you have ideas for topics that you want me to discuss, 35:51 please message us, you can share your comments on Facebook, you can email us, 35:58 um you can get a hold of us however you would like to share that. I do look at the comments below in the episodes as 36:04 well. So you can place your comments there. And once again, one of the best things you can do for me is like, 36:11 subscribe, and share so that we can spread the messages of what we’re doing. 36:16 I do this at no cost. I don’t make any money out of this. I do this as an 36:21 educational purpose for everybody else. I love doing it, but it really helps us 36:28 on the algorithms if you would be just willing to like, subscribe, and share. 36:33 So, thank you for spending your time with me. I know time is important.The post Episode 257 – Peptides for Sexual Wellness & Hormonal Health: PT-141, Growth Hormones, Bone Health & More! first appeared on Let's Talk Wellness Now.

Cindy Eckert, entrepreneur, investor, and the central figure in the new Paramount+ documentary The Pink Pill: Sex, Drugs & Who Has Control. The documentary film examines the decade-long, uphill battle to get the first FDA-approved medication for female libido, Addyi, approved and brought to market. Directed by Aisling Chin-Yee, the film highlights the stark contrast between the fast-tracked approval of Viagra for men and the intense, often biased scrutiny faced by advocates of "female Viagra.” Eckert fought for 10 years to bring Addyi to market, facing regulatory roadblocks and public skepticism, ultimately revealing systemic gender bias in healthcare. Reality Life with Kate Casey What to Watch List: https://katecasey.substack.com Patreon: http://www.patreon.com/katecasey Twitter: https://twitter.com/katecasey Instagram: http://www.instagram.com/katecaseyca Tik Tok: https://www.tiktok.com/@itskatecasey?lang=en Facebook Group: https://www.facebook.com/groups/113157919338245 Amazon List: https://www.amazon.com/shop/katecasey Like it to Know It: https://www.shopltk.com/explore/katecaseySee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A woman is in jail because she beaned her husband with a jar of pickles, along with a teacher who is in jail because she threw her shoe at a student, which I assume you're not supposed to do. Behold, the laundry folding robot, not to be outdone by the family cat who added something special to the pot of dinner soup. Five reasons to never live with a guy, yet they say we should go to bed at the same time as our spouse. It appears Viagra does a lot more than just make your penis hard, and in an unrelated story, Vegas is dying, and trying desperately to stay alive. I give you a new way to dine out, and it's illegal, plus a woman who was ghosted one too many times, and you might enjoy how she got her revenge. Bring on the flying car and the video gaming business is booming. Hey guys, how would you like to be a lot taller? It's going to cost you, plus driverless trucks are here, whether you like it or not. What made you walk out on a date, and is Reese's Cups going cheap with ingredients? Plus, your grip can tell you how long you will live. I give you all this information, and it's free.

Prostate cancer rarely announces itself. For many men, especially gay men over 40, the first sign comes too late. PSA testing can catch prostate cancer early, yet most men avoid the conversation or assume no symptoms means no problem. World renowned urologist Dr. Arthur L. Burnett II breaks down what every man needs to know about prostate and urological health, PSA testing, and why waiting for symptoms is a dangerous mistake. The conversation tackles cultural shame, medical avoidance, and how masculinity myths keep men from advocating for their health. This episode is a wake up call for gay men who want more years, better sex, and control over their bodies as they age. Key Takeaways from the Podcast: Why prostate cancer often shows no symptoms until it is advancedWhen gay men over 40 should ask for PSA testing and why it mattersHow health literacy and early action change long term outcomes About Dr. Bennett Arthur L. “Bud” Burnett II, M.D., MBA, FACS, is a trail-blazing and globally recognized urologist, educator, and researcher at Johns Hopkins University, where he has worked for more than 40 years. He serves as the Patrick C. Walsh Professor of Urology, Director of the Male Consultation Clinic. As a barrier-breaking leader, he is recognized as the first Black person to have achieved milestones in the urology profession as professor of urology at Johns Hopkins University, President of the Sexual Medicine Society of North America (SMSNA), and Board Member of the American Urological Association. Dr. Burnett has devoted his professional life to advancing patient care, performing thousands of prostate and urologic surgeries and pioneering minimally invasive, nerve-sparing techniques that help patients recover faster and maintain quality of life. His groundbreaking research on erectile function helped make oral therapies like Viagra possible, and he continues to innovate treatments that improve outcomes for men and women alike. Connect With Dr. Burnett Website Facebook Instagram LinkedIn Hey Guys, Don't Forget! Join the 40 Plus: Gay Men Gay Talk, monthly chats. - Learn More! Also, join our Facebook Community - 40 Plus: Gay Men, Gay Talk Community

Headline of the Week contender #5: The oldest butthole ever found is a 290-million-year-old fossil, Pittsburgharea Denny's worker facing charges after exposing himself to group of female customers...and it's not the first time, 'Boner Bears' chocolate syrup containing undeclared Viagra ingredient recalledSee omnystudio.com/listener for privacy information.

Headline of the Week contender #5: The oldest butthole ever found is a 290-million-year-old fossil, Pittsburgharea Denny's worker facing charges after exposing himself to group of female customers...and it's not the first time, 'Boner Bears' chocolate syrup containing undeclared Viagra ingredient recalled

Cindy Eckert (Addyi) joins JVN to talk all things women's sexual health, libido, and the science behind desire. Cindy breaks down her TIME100 Health feature, gives a preview of her upcoming Paramount+ documentary The Pink Pill: Sex, Drugs & Who Has Control, shares the iconic story of Addyi (often called the “female Viagra”) and her fight for better access to women's health care. Jonathan and Cindy also unpack the science of libido, how hormones, stress, and stigma affect sexual wellness, and why sexual health is directly connected to quality of life.  If you've ever wondered about low libido, women's sexual desire, Addyi, or how to talk about sexual health without shame - this episode is for you! Full Getting Better Video Episodes now available on YouTube.  Follow Cindy Eckert on @cindypinkceo  Follow us on Instagram @gettingbetterwithjvn Jonathan on Instagram @jvn Executive Producer, Chris McClure Producer, Editor & Engineer is Nathanael McClure Production support from Chad Hall Our theme music is also composed by Nathanael McClure. Check out the JVN Patreon for exclusive BTS content, extra interviews, and much much more - check it out here: www.patreon.com/jvn  Curious about bringing your brand to life on the show? Email podcastadsales@sonymusic.com. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Jeff Foxworthy jokes about viagra in his Netflix special, "The Good Ol' Days".

This week on The Armor Men's Health Show podcast, Donna Lee sits down with a very special guest — board-certified urologist Dr. Lucas Jacomides — for an honest, informative, and incredibly helpful conversation.They dive into a listener question many men quietly struggle with: “I had a prostatectomy in 2016 and have developed ED since then. I've tried Viagra and Cialis with no success. Is there help?”Dr. Jacomides breaks down why medications don't usually work after a prostatectomy and, more importantly, shares the real options available that can restore confidence, intimacy and quality of life.Got a question of your own? Visit www.armormenshealth.com and submit it — your question will be answered anonymously by a board-certified urologist on a future episode.Thanks for listening, laughing, and learning with us. If this episode helps you (or someone you love), be sure to share the podcast — and we'll see you right back here next week!

Steve Harvey Morning Show Online: http://www.steveharveyfm.com/See omnystudio.com/listener for privacy information.

The Supreme Court ruled this morning, in a 6-3 decision, that President Trump's tariffs are illegal. A key question now is whether the money collected under those tariffs must be returned to affected countries and companies. Meanwhile, California is proposing a one-time 5% tax on billionaires, prompting many wealthy residents to consider leaving the state. Mark takes your calls! Mark interviews Republican candidate for NY Governor Bruce Blakeman. Bruce addresses the challenges posed by potentially higher taxes in NYC, outlines his own tax plans, and contrasts them with those of his opponent, Hochul. He also explains why New York's state budget is larger than Florida's and describes how he would balance it as governor, offering insights on the latest developments in NYC politics.

Linda in Long Island called Mark to talk about Hillary Clinton's recent comments about Trump and suggested those comments should have led to her being jailed. Dr. Bob called in to discuss the positive effects of Viagra, building on the new research Mark mentioned during the show.

The Supreme Court ruled this morning, in a 6-3 decision, that President Trump's tariffs are illegal. A key question now is whether the money collected under those tariffs must be returned to affected countries and companies. Meanwhile, California is proposing a one-time 5% tax on billionaires, prompting many wealthy residents to consider leaving the state. Mark takes your calls! Mark interviews Republican candidate for NY Governor Bruce Blakeman. Bruce addresses the challenges posed by potentially higher taxes in NYC, outlines his own tax plans, and contrasts them with those of his opponent, Hochul. He also explains why New York's state budget is larger than Florida's and describes how he would balance it as governor, offering insights on the latest developments in NYC politics.See omnystudio.com/listener for privacy information.

Linda in Long Island called Mark to talk about Hillary Clinton's recent comments about Trump and suggested those comments should have led to her being jailed. Dr. Bob called in to discuss the positive effects of Viagra, building on the new research Mark mentioned during the show.See omnystudio.com/listener for privacy information.

What if the secret to healing your body isn't a prescription, it's on your plate?In this episode, Dr. William Li reveals the groundbreaking science behind how everyday foods can activate your body's natural defense systems, lower inflammation, and even reverse chronic disease. Dr. Li is an internationally renowned physician, scientist, and New York Times bestselling author of Eat to Beat Disease and Eat to Beat Your Diet. His research has led to the development of more than 40 new medical treatments impacting care for over 70 diseases.If you've ever felt confused about what to eat or frustrated that doctors don't talk about nutrition, this conversation will change everything. You'll discover why health isn't just the absence of disease, the shocking truth about inflammation and how to put it out fast, Dr. Li's simple gut health strategy that works overnight, how to detox your liver naturally, and why the "clean plate club" myth has been sabotaging your metabolism since childhood.Dr. Li also shares metabolism-boosting beverages, the natural "Viagra effect" hiding in beets and spinach, what GLP-1 drugs like Ozempic are really doing to your body, and a 60-second breathing technique that generates nitric oxide in your brain for instant mental clarity.This is food as medicine at its finest, practical, science-backed, and actually delicious.Ready to take control of your health? Hit follow and never miss an episode.

TRIGGERWARNUNG: Übergriffiges Verhaltenx--  **Euch hat diese Geschichte gefallen, aufgeregt oder ihr habt euch darin sogar wiedererkannt?** Das interessiert uns brennend! Schreibt uns in Kommentaren über Facebook und Instagram unter @drama_carbonara_podcast. Dort werdet ihr auch die in den Geschichten besprochenen Fotos finden und endlich sehen können, was wir sehen ... Falls ihr noch mehr fantastische Geschichten mit uns lesen wollt, können wir euch schon jetzt versprechen: das Repertoire ist unerschöpflich, wir staunen jedes Mal aufs Neue, was möglich ist. Abonniert Drama Carbonara auf allen gängigen Podcast Plattformen Über Sternchen, Bewertungen und Kommentare freuen wir uns natürlich auch extrem und feiern diese gern auch prominent in unserem Social Media Feed! Jede zweite Folge kommen ja großartige Gastlerser*innen zu uns ins Wiener Drama-Hauptquartier und unterstützt uns mit Interpretationen und Improvisationen. Wenn ihr einen Wunschgast für uns habt oder gern selbst mal vorbeischauen wollt, sagt Bescheid! Wir können nichts versprechen, aber wir freuen uns immer über Vorschläge. Wenn ihr Lust auf Extra-Content habt und euren Lieblingspodcasts auch finanziell unterstützen wollt , dann tut das herzlich gern mit einem Abonnement auf Steady und kommt in den Genuss des kompletten "Drama Carbonara"-Universums! Falls ihr daran interessiert seid, Werbung in unserem Podcast zu schalten, setzt euch bitte mit Stefan Lassnig von Missing Link in Verbindung. Verbindlichsten Dank! **Link zur Podcast Hörer:innen UMFRAGE!Danke für die Mitarbeit und euer wertvolles Feedback :) & hier zur legendären Spotify Drama Carbonara Soundtrack Playlist - folgen folgen folgen!! liebe Freund:innen des unberechenbaren Musik-Algorithmus!

This episode explores tadalafil (Cialis) as a potential longevity drug, though no randomized human trials prove it extends lifespan. Cialis works by blocking PDE5, enhancing nitric oxide signaling, and improving blood flow through vasodilation. Originally approved for pulmonary hypertension, it's also used for erectile dysfunction and BPH. Its 36-hour half-life makes it superior to Viagra for continuous longevity effects.   The host frames vascular aging and endothelial dysfunction as key drivers of age-related diseases (heart disease, stroke, dementia, kidney disease). Observational data shows Cialis users have 44% lower mortality, fewer cardiovascular events, reduced dementia risk, and lower mortality in diabetics. Additional benefits include improved cardiac function, reduced infarct size, arrhythmia suppression, and regression of left ventricular hypertrophy. A 2024 meta-analysis found it lowers hemoglobin A1C, possibly via improved microvascular perfusion, insulin sensitivity, and mitochondrial function.   Cialis crosses the blood-brain barrier and may improve neurovascular coupling and hippocampal plasticity, potentially benefiting those with or at risk of dementia. Safety is generally good with long-term daily use (2.5–5 mg), though cautions include avoiding use with nitrates, low blood pressure, or certain retinal disorders. Common side effects are headache, nasal congestion, and acid reflux. The host recommends consulting a doctor and references potential synergy with telmisartan.   Tadalafil (Cialis) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a604008.html](https://medlineplus.gov/druginfo/meds/a604008.html) Sildenafil (Viagra) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a699015.html](https://medlineplus.gov/druginfo/meds/a699015.html)   Key mechanisms mentioned Nitric Oxide (NO) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK554485/](https://www.ncbi.nlm.nih.gov/books/NBK554485/) Cyclic GMP (cGMP) — NCBI Bookshelf: [https://www.ncbi.nlm.nih.gov/books/NBK542234/](https://www.ncbi.nlm.nih.gov/books/NBK542234/)   Conditions mentioned in the episode Benign Prostatic Hyperplasia (BPH) — MedlinePlus: [https://medlineplus.gov/benignprostatichyperplasia.html](https://medlineplus.gov/benignprostatichyperplasia.html) Pulmonary Arterial Hypertension (PAH) — MedlinePlus: [https://medlineplus.gov/pulmonaryhypertension.html](https://medlineplus.gov/pulmonaryhypertension.html)   Blood pressure drug mentioned Telmisartan — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a601249.html](https://medlineplus.gov/druginfo/meds/a601249.html)   Other longevity / comparison drugs mentioned Metformin — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a696005.html](https://medlineplus.gov/druginfo/meds/a696005.html) Sirolimus (Rapamycin) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a602026.html](https://medlineplus.gov/druginfo/meds/a602026.html)   Side-effect helper mentioned Ibuprofen (Advil) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682159.html](https://medlineplus.gov/druginfo/meds/a682159.html)   Dementia meds mentioned Donepezil (Aricept) — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a697032.html](https://medlineplus.gov/druginfo/meds/a697032.html) Amantadine — MedlinePlus drug info: [https://medlineplus.gov/druginfo/meds/a682064.html](https://medlineplus.gov/druginfo/meds/a682064.html)   Lab markers mentioned Hemoglobin A1C (HbA1c) test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/](https://medlineplus.gov/lab-tests/hemoglobin-a1c-hba1c-test/) Insulin in blood test — MedlinePlus lab test: [https://medlineplus.gov/lab-tests/insulin-in-blood/](https://medlineplus.gov/lab-tests/insulin-in-blood/)   People referenced (where the claims were mentioned) Huberman Lab (Dr. Andrew Huberman) — site: [https://www.hubermanlab.com/](https://www.hubermanlab.com/) Clip about low-dose tadalafil (2.5–5mg) — X post: [https://x.com/tbpn/status/2022350426394534334](https://x.com/tbpn/status/2022350426394534334) Bryan Johnson (Blueprint) — site: [https://blueprint.bryanjohnson.com/](https://blueprint.bryanjohnson.com/) Dr. David Sinclair (Harvard profile) — site: [https://sinclair.hms.harvard.edu/people/david-sinclair](https://sinclair.hms.harvard.edu/people/david-sinclair)   Show Notes   00:00 Welcome to the Hart2Heart Podcast. 01:56 What Cialis Is: PDE5 Inhibition, cGMP & Nitric Oxide Explained 03:43 Approved Uses & Origin Story: Pulmonary Hypertension, ED, and BPH 05:33 Why Cialis Over Viagra: 36-Hour Half-Life & 24/7 Vascular Benefits 06:52 Vascular Aging 101: Endothelium, Perfusion, and Why It Drives Disease 11:14 What the Human Data Shows: Observational Evidence for Mortality, CVD & Dementia 13:04 Mechanisms Deep Dive: Heart Protection, Heart Failure, and Anti-Atherosclerosis 15:02 Cialis for Diabetics: Lowering A1C and Improving Insulin Sensitivity 16:21 Brain Effects: Blood–Brain Barrier, Neurovascular Coupling & Dementia Potential 18:21 Safety, Who Should Avoid It, and Daily Longevity Dosing (2.5–5 mg) + Wrap-Up   The Hart2Heart podcast is hosted by family physician Dr. Michael Hart, who is dedicated to cutting through the noise and uncovering the most effective strategies for optimizing health, longevity, and peak performance. This podcast dives deep into evidence-based approaches to hormone balance, peptides, sleep optimization, nutrition, psychedelics, supplements, exercise protocols, leveraging sunlight, and de-prescribing pharmaceuticals — using medications only when absolutely necessary. Beyond health science, we explore the intersection of public health and politics, exposing how policy decisions shape our health landscape and what actionable steps people can take to reclaim control over their well-being. Guests range from out-of-the-box thinking physicians such as Dr. Casey Means (author of "Good Energy") and Dr. Roger Sehult (Medcram lectures) to public health experts such as Dr. Jay Bhattacharya (Director of the National Institutes of Health (NIH) and Dr. Marty Mckary  (Commissioner of the Food and Drug Administration (FDA) and high-profile names such as  Zuby and Mark Sisson (Primal Blueprint and Primal Kitchen). If you're ready to take control of your health and performance, this podcast is for you.We cut through the jargon and deliver practical, no-BS advice that you can implement in your daily life, empowering you to make positive changes for your well-being.   Connect with Dr. Mike Hart Instagram: @drmikehart Twitter: @drmikehart Facebook: @drmikehart

Follow Dave & Mahoney everywhere:Instagram: @daveandmahoneyTikTok: @daveandmahoneyFacebook: @daveandmahoneyYouTube: @daveandmahoneyAgree? Disagree? Want to yell at us?Voicemail: 833-YO-DUMMY Additional Content: daveandmahoney.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Most men reach for Viagra without ever hearing about the device that could change everything.There's a drug-free tool that creates an erection in minutes, may outperform pills in satisfaction rates, and can even help protect long-term penile health. Yet almost no one talks about it. In this episode, you'll uncover how a penis pump really works, how it compares head-to-head with Viagra, who should avoid it, and the exact safety steps that make all the difference.If better performance and smarter choices matter, press play and discover an option most men never knew they had.--------------Resources mentioned:Modern Man CribMediterranean DietGood Morning Wood SmoothieRenew with Dr. Anne--------------Curious about how you can boost your bedroom game and build lasting confidence? Check out the course at getwoodnow.com and start your journey to feeling like yourself again!--------------If you enjoyed this episode and want to learn more and get more tips, subscribe to The Modern Man newsletter for exclusive content delivered straight to your inbox! https://dranne.co/themodernman--------------Follow Me On:InstagramTwitterFacebookTikTokYouTube--------------For all links and resources mentioned on the show and where to subscribe to the podcast, please visit https://truongrehab.com/penis-pump-versus-viagra--------------Want to regain control of your sex life? It's time to reverse the effects of ED on your life. Join the Modern Man Club and embark on your journey to complete recovery and community.--------------Reveal the FREE treatment most men ignore that solves thousands of erectile dysfunction cases every year, plus the 5 biggest...

Your fluoride toothpaste and antiseptic mouthwash may be sabotaging your cardiovascular health and canceling out the benefits of your daily workout. In today's episode, I sit down with Dr. Nathan Bryan to uncover how nitric oxide deficiency drives high blood pressure, erectile dysfunction, insulin resistance, and even Alzheimer's disease. Nathan explains why 50% of men on Viagra don't respond with better erections, how mouthwash kills the bacteria your body needs to produce nitric oxide, and why heavy metals scavenge this critical molecule before it can reach your blood vessels.  We explore practical solutions such as using nitric oxide lozenges, reducing exposure to harmful substances, and supporting the oral microbiome to restore your body's natural production.   "Without nitric oxide, your body cannot heal. It's not going to get adequate blood flow, you're going to experience runaway inflammation, oxidative stress, and immune dysfunction." ~ Nathan Bryan   In This Episode: - Nitric oxide and its importance for our health - Nitric oxide and erectile dysfunction - Exercise and bacteria for nitric oxide production - Oral microbiome and dangers in your mouthwash - Signs and consequences of low nitric oxide - Age-related decline in nitric oxide production - Heavy metals and toxins that scavenge nitric oxide - How to restore nitric oxide - Nitric oxide lozenges and skin care solutions - The beet product myth debunked - High blood pressure medication limitations - Who needs nitric oxide supplementation?   Products & Resources Mentioned: N1O1 Nitric Oxide Lozenges: Available at https://n101.com  N1O1 Nitric Oxide Skincare Serum: Perfect for youthful skin maintenance at https://n101.com  Puori Grass Fed Whey Protein: Use code WENDY at http://Puori.com/wendy for 32% off, plus a free shaker with a subscription. Tru Energy Skincare Serum: Get an exclusive deal at https://trytruenergy.com/wendy  Organifi Collagen: Save 20% with code MYERSDETOX at https://organifi.com/myersdetox  Chef's Foundry P600 Ceramic Cookware:  Take 50% off plus an extra 20% with code WENDY20 at https://chefsfoundry.com  Heavy Metals Quiz: Visit https://heavymetalsquiz.com    About Nathan Bryan: Dr. Nathan Bryan earned his Bachelor of Science in biochemistry from UT Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport, where he received the Dean's Award for Excellence in Research. He completed postdoctoral training as a Kirschstein Fellow at Boston University School of Medicine and at the Whitaker Cardiovascular Institute before joining the faculty at UT Health Science Center at Houston, recruited by Nobel Laureate Ferid Murad. Nathan is also the author of The Secret of Nitric Oxide, available on his website. With over 25 years of nitric oxide research, he has made seminal discoveries, founded Bryan Therapeutics for nitric oxide-based drugs in heart disease, Alzheimer's, and wound healing, and created the successful consumer nitric oxide product line available at https://n101.com    Disclaimer The Myers Detox Podcast was created and hosted by Dr. Wendy Myers. This podcast is for information purposes only. Statements and views expressed on this podcast are not medical advice. This podcast, including Wendy Myers and the producers, disclaims responsibility for any possible adverse effects from using the information contained herein. The opinions of guests are their own, and this podcast does not endorse or accept responsibility for statements made by guests. This podcast does not make any representations or warranties about guests' qualifications or credibility. Individuals on this podcast may have a direct or indirect financial interest in products or services referred to herein. If you think you have a medical problem, consult a licensed physician.

In this episode of Med School Minutes, we sit down with Dr. Arthur Burnett, a Johns Hopkins urologist, researcher, and professor whose work helped unlock the science behind Viagra and reshape how medicine understands male sexual health.In recognition of Black History Month, we reflect on Dr. Burnett's groundbreaking career, his impact on men's health research, and the importance of representation and mentorship in medicine.From nitric oxide and vascular health to aging, prostate cancer, and longevity, this conversation explores how scientific discovery shapes both medicine and culture, and what future physicians should know.

Full episodes and much more available on Patreon.com/slopquest Comedian Ryan O’Neill and Illustrator Andrew DeWitt bring you the dumbest takes on news, movies and ridiculous business ideas every week on Slop Quest! There’s a little Tina Turner talk at the start of the show. Ryan has a series of injuries when his luck runs out. Andy has a 14 hour delay on a flight. Ryan has his mind blown when he finds out lots of Bible Belt Christians don’t consider Catholics Christian. Then Andy attends a sword fighting class behind a CVS. Andy hides most of Reddit from himself. Then Andy recalls a product for getting lap dances that are just rubber underwear with lube in them. Ryan can’t believe that sexual surrogates are real. Ryan tries to figure out why Airforce Amy was a popular sex worker. Then the boys talk about Bill Gates a bit. Then Andy finds out how many dudes in their thirties have to be on viagra. O’Neill works out at an elementary school playground in Texas.

Full Show Notes: bengreenfieldlife.com/lnkyal/ In this episode, you'll get to discover the fascinating realm of revolutionary peptides with two-time guest, Kyal Van Der Leest — a distinguished naturopath, nutritionist, supplement formulator, and the founder of LVLUP Health (use code BEN10 to save 10%). Discover how these powerful compounds can rapidly repair tissues, elevate your energy by boosting NAD levels, sharpen your mind, and even naturally enhance sexual health, offering alternatives to medications like Viagra. Kyal Van Der Leest is the founder, formulator, and face of LVLUP Health, an Australian-based supplement company. Under his guidance, LVLUP Health (use code BEN10 to save 10%) has created a diverse range of cutting-edge supplements utilizing incredibly powerful ingredients that you may not have heard of before. His formulations aim to simplify complex health protocols, reducing the need for multiple products by offering all-in-one solutions that make supplementation easy and effective. Episode Sponsors: Apollo: Apollo is a safe and non-invasive wearable that actively improves your sleep. Head over to apolloneuro.com/bengreenfield and use code BENGREENFIELD for $90 off. Just Thrive: Just Thrive Probiotic is the only probiotic clinically proven to arrive 100% alive in your gut, wrestling in less bloat, better energy, and even clear skin. Digestive Bitters packs 12 science-backed herbs in one tasteless capsule that jumpstarts your digestion and supports GLP-1 production so cravings don’t control you. Visit justthrivehealth.com/BENand save 20% with promo code BEN. See the difference for yourself or get a full product refund, no questions asked. Sunlighten: Sunlighten's patented infrared sauna technology delivers the highest quality near, mid, and far infrared wavelengths to reduce inflammation, boost mitochondrial function, enhance detox pathways, and optimize recovery—backed by 25+ years of clinically proven, non-toxic innovation. Save up to $1,400 at get.sunlighten.com/ben with code BEN. Formula IQ: Recuperate IQ by Formula IQ is a comprehensive copper supplement designed to support mitochondrial energy, iron balance, and metabolic health by pairing bioavailable copper with essential cofactors your body needs for proper utilization, which is especially crucial if you've been under chronic stress or supplementing with high-dose zinc. Try it at formulaiq.com and use code BEN for 10% off. LeelaQ: Not only do LeelaQ’s products neutralize EMFs, increase ATP production, optimize HRV, and improve blood flow, but they've been third-party proven to do so in placebo-controlled double-blind studies. Visit leelaq.com and use code BEN10 for 10% off. See omnystudio.com/listener for privacy information.

Wegovy is in the legal spotlight as lawsuits target “copycat” versions of the blockbuster drug — and we dig into how some medications become famous for side effects, like Viagra. (Spoiler: it was originally developed as a heart medication to treat chest pain/angina before its unexpected “other” effect changed everything. Then, we break down why the Super Bowl is still the most-watched, biggest revenue machine in American sports — and what makes it unmatched as an event. Plus, Super Bowl 60 security ramps up to a whole new level: a massive, coordinated operation with dozens of agencies working together and staying on high alert. And a fun SoCal tie-in: Seahawks QB Sam Darnold has roots in Capistrano Beach, California — and we talk about the local angle heading into the big game. See omnystudio.com/listener for privacy information.

Grâce à une fiscalité avantageuse, l'Irlande a su attirer les géants pharmaceutiques, au point d'en faire l'un des piliers de son économie. Mais Donald Trump brandit désormais la menace de droits de douane, pour pousser ces entreprises à relocaliser aux Etats-Unis. Or, les médicaments représentent près de la moitié des exportations irlandaises, avec les États-Unis comme premier client ! En Europe, l'Irlande serait ainsi le pays le plus exposé. Près de Cork, Ringaskiddy, surnommé le « village du Viagra », retient son souffle. Reportage de Clémence Pénard. John n'avait que 22 ans quand Pfizer s'est installé à Ringaskiddy. C'était en 1969 : « Tu vois, juste là, le château d'eau ? L'espèce de champignon, là ! Ça appartient à Pfizer !  » Le succès est tel que l'entreprise s'empresse de construire deux autres usines. Si bien qu'aujourd'hui, sous les coups de 8 heures, le site devient une véritable fourmilière : « Le matin, les routes sont totalement saturées : les files de voitures s'étendent sur des kilomètres. Et c'est la même chose le soir ! Une autoroute devait être construite il y a trente ans… Bon, elle doit être terminée d'ici trois ans. On vit dans l'espoir ! » Le « Pfizer Stop » Un arrêt de bus, le « Pfizer Stop », a tout de même été créé, rien que pour les salariés qui produisent, depuis 1998, le médicament le plus tonique de la région : le viagra !  « À l'époque, on n'arrivait même pas à prononcer le nom : "Pf i zeur" ! Mais tout le monde voulait y travailler, absolument tout le monde. Les salaires étaient multipliés par quatre ! Même le fournisseur de papier toilette était devenu riche ! » Et il n'a pas fallu longtemps pour que le « village du Viagra » attire d'autres géants pharmaceutiques. Aujourd'hui, les Américains Johnson & Johnson, Thermo Fisher ou encore BioMarin profitent eux aussi du port de cet ancien village de pêcheurs, idéal pour exporter leurs médicaments !  Et à seulement 20 km de là, Lilly fabrique Mounjaro et Zepbound, deux médicaments anti-obésité, best-sellers aux États-Unis !  Ambiance à Ringaskiddy et dans les villages voisins Ainsi, dans Ringaskiddy et les villages voisins, ce sont plus de 20 000 personnes qui travaillent pour ces mastodontes, souvent de génération en génération. Audrey Buckley est élue locale du Fianna Fáil, le parti au pouvoir : « S'il arrivait quoi que ce soit à l'industrie pharmaceutique ici, ce serait tout simplement dévastateur pour toute la région. Dévastateur… Aujourd'hui, au dîner autour de la table, les mêmes questions reviennent sans cesse : est-ce que tels travaux ont démarré à l'usine? Est-ce qu'il y a de nouveaux projets ? Or, tout semble à l'arrêt. C'est une énorme source d'angoisse, les gens repoussent l'achat d'une voiture, l'extension de la maison, et ainsi de suite. Ils dépensent moins, c'est sûr, donc on voit déjà des effets ! »  Économiste à l'université de Cork, Eleanor Doyle voit aussi un ralentissement du secteur, mais tente tout de même de rassurer : « Pour les usines pharmaceutiques, les délais pour obtenir les autorisations de construction sont si longs, qu'à moyen terme, une délocalisation est peu envisageable ! » Pour l'instant, l'Irlande profite d'un répit, l'administration américaine semblant se concentrer sur d'autres régions du monde.

On today's Extra, Taking Viagra, 4 Dishwashers, & Hug Coupons Learn more about your ad choices. Visit podcastchoices.com/adchoices

Send us a text & leave your email address if you want a reply!What if we told you there's a peptide that works on your brain's desire centers, not just your genitals, and it's giving 78-year-olds spontaneous teenage-level erections? Meet PT 141, the game-changing "brain Viagra" that's quietly revolutionizing sexual health. Dr. Willow and Leah break down the science behind peptides, share real transformation stories and explain why your gut health might be the missing piece in your libido puzzle. This is a deep dive into how peptides work as "jumper cables" for your entire system, why weight loss peptides are boosting sexual confidence, and the safety protocols you need to know before you start.EPISODE HIGHLIGHTS• PT 141 works on your brain, not just blood flow – flips the switch on desire and extends higher arousal states• 78-year-old gets teenage-level erections • Clinical study proves it works – 50% of 1,200 women saw real libido improvement vs 20% on placebo• Gut health kills libido – how inflammation and bloating destroy sexual desire• Weight loss peptides boost sexual confidence – feel better in your body, want more sex• Start low and slow safety protocols – dosage guidance and which peptides combine safely• Peptides supercharge hormone therapy – make HRT work 10x better plus other anti-aging benefitsVIDEOS, LINKS & RESOURCES MENTIONED IN THE EPISODE CAN BE FOUND HEREThe Live Power of Pleasure Free Summit | Feb 11-12, 2026 > While everyone else is buying predictable Valentine's gifts, you'll be learning from the world's most innovative sexuality teachers how to access states of intimacy that most people don't even know exist. Free to Register: https://www.sexreimagined.com/power-of-pleasure ROOTED IN DESIRE. A Journey Back to Your Feminine Essence If you're a heart-centered woman ready to embody your femininity, awaken your sacred sexuality, and fall deeply in love with yourself, this immersion is for you. Register: https://www.sexreimagined.com/rooted-in-desire THE MALE GSPOT & PROSTATE MASTERCLASS. This is for you if… You've heard of epic anal orgasms, & you wonder if it's possible for you too. Save 20% Coupon PODCAST20. Support the show FREEBIE- Introduction to Tantric Kissing Video and Workbook SxR Website Dr. Willow's Website Leah's Website

In today's episode of Health Youniversity, we're diving into the often-overlooked side of the fertility conversation: male factor infertility.Join Dr. Susan as she sits down with Dr. Arthur "Bud" Burnett II, M.D., MBA, FACS, a trailblazing urologist and globally recognized expert at Johns Hopkins University with over 40 years of experience. Dr. Burnett is a pioneer in male sexual health research—his groundbreaking work on erectile function helped make oral therapies like Viagra possible.Dr. Burnett reveals a critical truth: male factor accounts for up to 50% of infertility cases, yet men's reproductive health is still frequently neglected in fertility conversations. This episode changes that.You'll learn what lifestyle factors are silently damaging sperm quality (processed foods, stress, sleep deprivation, environmental toxins), when men should consider getting a semen analysis, what really matters in sperm testing (spoiler: it's not just count), and why the 72-day spermatogenesis cycle means changes take time. Dr. Burnett also shares insights on the emotional and mental health components of male fertility, why young men need primary care providers after pediatrics, and the exciting advances coming in male reproductive medicine through AI and genetics.But this conversation goes deeper than fertility alone. Dr. Burnett discusses his upcoming book "Penis Confidential" (2026), which tackles what it means to be a man in modern society—from helping teenagers navigate healthy masculinity to supporting older men through prostate cancer and sexual dysfunction. He challenges outdated notions of "toughness" that prevent men from seeking emotional and medical support, and advocates for destigmatizing men's health conversations.Listen to this episode if you're a couple trying to conceive and want to address both partners' health, a man concerned about sperm quality or reproductive health, someone supporting a partner through fertility challenges, a young man (or parent of one) seeking guidance on male health, a healthcare professional wanting better male fertility resources, or anyone interested in redefining healthy masculinity for the next generation. 

Dr. Maria Sophocles has been a leader in women's healthcare for nearly 30 years, specializing in menopause management and female sexual health. She founded Women's Healthcare of Princeton, a progressive gynecology practice, and has been a visiting professor and NIH researcher in Switzerland. A board-certified ob/gyn and Menopause Society Certified Practitioner, she has pioneered innovative treatments, including CO2 laser therapy for vaginal atrophy. She serves as CMO of EMBR Labs, Director of Women's Health Services for Curia Health, and is an advocate for women's health policy. Dr. Sophocles' TED talk "What Happens to Sex in Midlife" has garnered over 1.2 million views in total and her forthcoming book, The Bedroom Gap, will be released February 10th. She is currently working on a documentary about Sex, Menopause, and Gender Equality called HOT! In this episode, Tara and Dr. Maria Sophocles unpack the bedroom gap by exploring how physiology, hormones, shame, religion, porn culture, relationship dynamics, and communication issues all interact to block women's libido and pleasure, while offering practical strategies like self-pleasure, better sex education, hormone support, and intentional intimacy to rebuild desire and connection at any age.  RESOURCES: Learn more about Dr. Sophocles here: https://mariasophoclesmd.com Her viral TED talk with 1.2M+ views: https://www.ted.com/talks/maria_sophocles_what_happens_to_sex_in_midlife_a_look_at_the_bedroom_gap?language=en  Instagram: @mariasophoclesmd Pre-order her book The Bedroom Gap on Amazon here: https://amzn.to/48X1XYk  Watch her previous podcast episode on Inside Out Health Podcast: https://www.taragarrison.com/blog/drsophocles  Get 15% off Peluva minimalist shoe with coupon code COACHTARA here: http://peluva.com/coachtara CHAPTERS: 00:00 Intro 00:05:05 – An open, no‑holding‑back conversation about sex, libido, and midlife.
 00:07:00 – How most young people get their "sex education" from porn because adults and schools avoid real conversations about sex and pleasure.
 00:08:17 – Dr. Sophocles debunks the Hollywood myth that women typically orgasm easily from penetrative sex alone and explains how misleading this is.
 00:09:11 – 70–90% of women need clitoral stimulation to orgasm and how shame and unrealistic expectations make many feel "broken."
 00:11:02 – The concept of the "bedroom gap": Viagra and support for male performance versus lack of equivalent attention to women's sexual needs.
 00:12:18 – Dr. Sophocles explains that orgasm releases endorphins, dopamine, and oxytocin and argues that being sexually active can be part of a longevity plan.
 00:20:00 – Practical advice to treat sex and intimacy like a non‑negotiable appointment, starting with G‑rated cuddling and rebuilding erotic connection gradually.
 00:49:31 – Why comprehensive, pleasure‑based sex education (with the Dutch example) leads to healthier sexual patterns and fewer unwanted outcomes.   WORK WITH TARA: Are You Looking for Help on Your Wellness Journey? Here's how Tara can help you: TRY MY APP FOR FREE: http://taragarrison.com/app INDIVIDUAL ONLINE COACHING: https://www.taragarrison.com/work-with-me CHECK OUT HIGHER RETREATS: https://www.taragarrison.com/retreats   SOCIAL MEDIA:  Instagram @coachtaragarrison TikTok @coachtaragarrison Facebook @coachtaragarrison Pinterest @coachtaragarrison   INSIDE OUT HEALTH PODCAST SPECIAL OFFERS: ☑️ Upgraded Formulas Hair Test Kit Special Offer: https://bit.ly/3YdMn4Z ☑️ Upgraded Formulas - Get 15% OFF Everything with Coupon Code INSIDEOUT15: https://upgradedformulas.com/INSIDEOUT15 ☑️ Rep Provisions: Vote for the future of food with your dollar! And enjoy a 15% discount while you're at it with Coupon Code COACHTARA: https://bit.ly/3dD4ZSv   If you loved this episode, please leave a review! Here's how to do it on Apple Podcasts: Go to Inside Out Health Podcast page: https://podcasts.apple.com/us/podcast/inside-out-health-with-coach-tara-garrison/id1468368093 Scroll down to the 'Ratings & Reviews' section. Tap 'Write a Review' (you may be prompted to log in with your Apple ID). Thank you!

Matt Roeske, the master of rabbit holes, is back for our third interview and as usual, this one does not disappoint.One of my goals is to encourage everyone to rethink what they already know (I put myself in that target audience) and Matt is definitely one to cause us to do just that.Many of us are seeing that what we have been told about pretty much everything is either a flat out lie or twisted in some regard. In this mind-expanding conversation, Matt once again challenges conventional wisdom on every level—from eating raw meat to understanding the real value of silver, from mouldy berries that heal to the suppressed knowledge of a man who cured himself of C in the 1970s.We also learn of the fascinating tree resin, Dragon's Blood. Truly one of mother nature's healers.Whether you're ready to question the food pyramid, rethink precious metals, or discover why your grandparents knew more about health than modern doctors, this conversation will shake your assumptions and offer practical solutions for true independence in 2026 and beyond.In today's show:5:11 - Silver at $90/ounce, highest ever, expected to keep rising due to Federal Reserve money printing6:35 - 2026 mirrors 1890s McKinley Tariffs playbook: tariffs, farmers struggling, precious metals surging - Trump quoted McKinley as inspiration10:17 - Asia blocked silver trade agreements, creating scarcity - bullion stores sold out everywhere11:30 - Germany's currency 1933-1950s was silver after hyperinflation destroyed paper money13:36 - Copper penny eliminated a month ago because copper value exceeded penny's face value16:05 - Matt's raw diet for 11-12 months: raw meat, raw milk, raw honey18:18 - How Matt's new diet activated his super smelling sense19:15 - Chemtrails deployed most heavily during full moons20:30 - Mouldy berries pull heavy metals from body21:01 - Aajonus Vonderplanitz healed afflictions with raw diet in 1970s-80s23:43 - Vonderplanitz said viruses are fake, parasites don't harm in 1980s-90s30:30 - The mysterious stories around Aajonus's death one year after Doctor's show appearance39:38 - Dr. Pottenger study: 900 cats on raw meat/milk became lions, cats on processed food became disabled and infertile44:10 - Pork and nitric oxide content and how Viagra replaced it46:51 - 5,000 PubMed studies show parasites grow in animals to eat heavy metals, not contagious51:10 - Mouldy berries create trippy, mushroom-like detox effect51:30 - Grandmothers traditionally added mouldy berries to soup, applesauce, raw milk for health52:30 - Penicillin shots as children and allergies to natural mould54:25 - Mouldy blueberries and heavy metals60:30 - Dragon's blood and severe eczema head-to-toe, receding gums60:50 - Dentists reported patients' gums regenerating with coconut oil and dragon's blood61:05 - Testimonial: arthritis inflammation 99% gone with four dragon's blood capsules daily64:07 - Electro culture book coming spring 2026 proving no scarcity exists65:43 - AI clones of Matt's voice/image scamming people, DO NOT purchase from these fake companies!and more!If you enjoyed this episode, please share if you dare and consider going to www.sovereigncollective.org/shop to check out my offerings and get a deal while supporting the podcast. I'll be adding more great offerings there over time.Matt is highly censored, so you'll have a hard time finding him on the major mainstream channels, or you'll have to look hard to find him.Peruse his site and use code Sascha10 to save on some goodies including Dragon's Blood:https://cultivateelevate.com/Matt posts on various platforms and does a regular live every week on Monday, among other videos and posts. Find him here:https://rumble.com/user/CultivateElevatehttps://odysee.com/@CultivateElevate:e2telegram: @ElevateThyMindhttps://www.instagram.com/cultivateelevate/--------------------------------------------Find me:Facebook: https://www.facebook.com/saschakalivoda/IG: https://www.instagram.com/saschaksays/Website: www.sovereigncollective.orgYou Tube: https://www.youtube.com/@saschasays/videosBitchute: https://www.bitchute.com/channel/Tfl1Zo021FcXEmail: sascha @ sovereigncollective.org

Broadcast from KSQD, Santa Cruz on 1-22-2026: An emailer from Canada asks about long-term Remicade (infliximab) use for her 16-year-old daughter's ulcerative colitis. Dr. Dawn explains the drug blocks tumor necrosis factor, which stops autoimmune attacks but also weakens infection defense—increasing risk of fungal infections, tuberculosis, and after about 10 years, slightly elevated blood cancer risk. She recommends the daughter practice good hygiene and mask in high-risk settings. For achieving full remission, she suggests vitamin D levels around 75-80, DHEA supplementation, strict gluten avoidance due to its pro-inflammatory effects, and working with a certified functional medicine practitioner to heal the gut and potentially withdraw medication. Dr. Dawn presents a case study of a 27-year-old woman with progressive weakness, pins-and-needles sensations, and impaired balance. Despite normal B12 blood levels, elevated homocysteine and methylmalonic acid revealed functional B12 deficiency from using 20-30 nitrous oxide whippets daily. Nitrous oxide oxidizes the cobalt atom in methylcobalamin, permanently inactivating the enzyme needed for myelin sheath maintenance. Treatment requires months of daily B12 injections with recovery taking up to 84 weeks. She warns that nitrous oxide also interacts dangerously with Viagra-type drugs (causing dangerous blood pressure drops), methotrexate, stimulants, hallucinogens, and respiratory depressants. She describes Canadian researchers developing a miniaturized 3D printer for vocal cord repair. After removing nodules that cause hoarseness, the device prints hydrogel along the wound to create a flat surface preventing keloid-like regrowth, rather like spackling a wall before healing occurs underneath. Dr. Dawn discusses lipoprotein(a), written as Lap(a), a genetic cardiovascular risk factor discovered in the 1960s. This relative of LDL carries a protein that promotes blood clots, thus raising heart attack and stroke risks. In a recent large survey, only about 14% of people have been screened despite its significance. New drugs like pelicarsin can reduce Lp(a) levels up to 80%,trials underway to confirm a benefit of reduced cardiac events. She notes tennis star Arthur Ashe had high Lp(a) contributing to his coagulopathy. A natural option is already available. She recommends lumbrokinase, derived from earthworms and used in traditional Chinese medicine, as an existing treatment that combats high Lp(a) and counteracts its procoagulant effects. The product Boluoke is commercially available, offering an alternative to high-dose niacin which causes intolerable flushing and diarrhea. Dr. Dawn reports research finding people with anxiety disorders have 8% lower choline levels in brain regions regulating emotion. Increasing choline could help. Choline sources include eggs (two eggs provide 300mg of the 500mg daily choline need), organ meats, salmon, soybeans, and lecithin supplements.

Join My Private Group: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://theaxioncollective.manus.space/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Email List: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://huntershealthhacks.beehiiv.com/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Get My Book On Amazon: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://a.co/d/avbaV48Download⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The Peptide Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://peptidecheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Download The Bioregulator Cheat Sheet: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://bioregulatorcheatsheet.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠1 On 1 Coaching Application: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamscoaching.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Book A Call With Me: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamscall.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Supplement Sources: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamssupplements.carrd.co/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Amazon Storefront: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.amazon.com/shop/hunterwilliams/list/WE16G2223BXA?ref_=cm_sw_r_cp_ud_aipsflist_R7QWQC0P1RACB2ETY3DY⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Socials:Instagram: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://www.instagram.com/hunterwilliamscoaching/⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Video Topic Request: ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠https://hunterwilliamsvideotopic.carrd.co/⁠⁠⁠⁠Today's episode is all about Viagra, but not in the way most people think about it. We're talking sildenafil for longevity, healthspan, and performance. The “little blue pill” has a reputation as an erectile dysfunction drug, but when you actually look at the mechanism and the data, it's doing way more than that.I've been a proponent of low-dose Cialis for a long time, and I still am. But lately I've been experimenting with rotating between Cialis and Viagra because I notice I can build a tolerance to Cialis over time. It still works, but I don't feel the performance benefits as strongly unless I push the dose higher. What I've found is that going four weeks on low-dose Cialis, then four weeks on low-dose Viagra, seems to keep me more responsive overall while still giving me the benefits that matter for longevity.In this episode, I break down the real mechanism. Sildenafil is a PDE5 inhibitor that amplifies nitric oxide signaling and raises cGMP throughout the body. That means systemic vasodilation, improved endothelial function, better blood flow to organs, and anti-thrombotic effects through reduced platelet activation. And the downstream effects get even more interesting. We're talking mitochondrial signaling through PKG, potential ischemic preconditioning effects, PGC-1α and mitochondrial biogenesis, AMPK activation, and dampening inflammatory pathways like NF-kB. This is why I think sildenafil deserves a seat at the longevity table, not just a spot in the performance category.Then we get into the human data and what I think is most compelling. Large datasets show associations with lower rates of cardiovascular events and lower all-cause mortality in PDE5 inhibitor users. We talk heart attacks, strokes, endothelial repair, and why this class may act like an exercise mimetic for certain people by improving hemodynamics and oxygen delivery. We also cover pulmonary benefits, including its FDA-approved use for pulmonary arterial hypertension, and why that matters for aging lungs, sleep apnea-related pulmonary issues, and even high-altitude physiology.The brain section is the one that makes most people stop and rethink everything. There are observational datasets suggesting meaningfully lower Alzheimer's and dementia incidence in sildenafil users, plus plausible mechanisms tied to cerebral blood flow, synaptic plasticity, inflammation reduction, and mitochondrial support inside the brain. I'm not saying it's a magic bullet. I am saying it's one of the more interesting repurposing conversations in longevity right now.

Pepper in Your Socks + Viagra to Stay Warm by Maine's Coast 93.1

Viagra Warmth and Tracking Your Partner- Full Show 1-20-26 by Maine's Coast 93.1

The best-seller herbal supplements we're covering today are yohimbe & horny goat weed. They placed #30 and 31 on the list we're using for this sequence of episodes. These two are marketed & sought-after as “male aphrodisiacs”, “testosterone boosters”, and even “herbal Viagra”. While it's true that each can “help” with some forms and manifestations of erectile dysfunction, in the short term or “in the moment”, they cannot correct the underlying issues… and might even make them worse.They're also quite potent, energetically speaking: heating, drying, and tonifying to a high degree. These qualities are primarily derived from potent constituents such as yohimbine and icariin. Each herb also possesses a multitude of other constituents apart from those more famous ones, which means its actions are diverse and in some cases self-contradictory.There's also a very serious problem in the supplement market for these herbs, which is that these products are frequently contaminated or adulterated. Many cases of ‘herbal' supplements for ED have been found to contain pharmaceutical drugs. In other words, that “herbal Viagra” was actually just… Viagra. Of the two of these herbs, Epimedium is significantly safer – but to be honest, we don't advise people to work with either of these plants. Other methods of addressing the issue at hand are more successful and more permanent, starting with herbal work to improve circulation and emotional steadiness. That's perhaps not as exciting as “herbal Cialis”, but it's safer and more realistic!CLICK HERE FOR FULL SHOW NOTES & REFERENCESIt's worth emphasizing that the majority of cases of erectile dysfunction, and several other types of sexual dysfunction or performance issues, are attributable to circulatory issues rather than hormonal imbalances. If you're looking for herbs to help with this trouble, and to address circulatory, blood, and heart health more broadly, then our course Cardiovascular Health is for you!Like all our offerings, this online video course comes with free access to twice-weekly live Q&A sessions with us, lifetime access to current & future course material, open discussion threads integrated in each lesson, an active student community, study guides, quizzes & capstone assignments, and more.If you have a moment, it would help us a lot if you could subscribe, rate, & review our podcast wherever you listen. This helps others find us more easily. Thank you!!Our theme music is “Wings” by Nicolai Heidlas.Support the showYou can find all of our online herbalism courses at online.commonwealthherbs.com!

Share your guest suggestions hereMail - connect@beerbiceps.comLink - https://forms.gle/aoMHY9EE3Cg3Tqdx9Check out BeerBiceps SkillHouse's YouTube 1O1 Course - https://youtube.beerbicepsskillhouse.in/youtube-101For all BeerBiceps vlog content Watch Life Of BeerBiceps - https://www.youtube.com/@LifeOfBeerBicepsBeerBiceps SkillHouse को Social Media पर Follow करे :-YouTube : https://www.youtube.com/channel/UC2-Y36TqZ5MH6N1cWpmsBRQ Instagram : https://www.instagram.com/beerbiceps_skillhouseWebsite : https://beerbicepsskillhouse.inFor any other queries EMAIL: support@beerbicepsskillhouse.comIn case of any payment-related issues, kindly write to support@tagmango.comLevel Supermind - Mind Performance App को Download करिए यहाँ से

Happy New Year!Join us for Part 1 of our first episode of the New Year where we have an honest Talk with the bros from the 90's Baby Podcast!In this episode, we talk with 90's Baby about what life was like growing up in the 1990s, how things have changed since then, and how our generation perceives the world today. There are funny stories and real talk about culture, life, and identity.IMO Podcast is about honest and real conversations. This episode will make you think, laugh, and remember your own childhood. If you grew up in the 90s or want to know what it was like, this video is for you.

Deux Belges s'arrêtent devant une déjection animale, à l'hôpital un patient prend un médicament "encore plus fort que le Viagra", et un Belge délivre à son ami le secret de la longévité de son couple... Découvrez les 3 histoires drôles du jour ! Tous les jours, en podcast, retrouvez une compilation des meilleures blagues de vos Grosses Têtes préférées.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

It's the first ever episode of Mark Martin Archive! Mark & his son Matt share some great stories celebrating Harry Gant & Kurt Busch, who are both going into the NASCAR Hall of Fame this year. Mark also discusses having Rodney Childers as a crew chief late in his career. Charlie Marlow has some questions from the audience like how did Mark recommended Matt Kenseth to Jack Roush? Did you know that Mark scored more points than any other NASCAR driver in the 1990's? And was it weird being sponsored by Viagra? Mark answers all these questions & more!#nascar #racing #markmartin

About 24.2% of U.S. men today screen positive for erectile dysfunction (ED), while global rates range from 3% to 76.5%, showing it's a common health problem that affects men of all ages A 2025 study in the American Journal of Clinical and Experimental Urology found that ED is influenced by genes that also raise risk for obesity, diabetes, heart disease, and addiction, tying erection problems to long-term heart health ED is usually multifactorial, with vascular, neurogenic, hormonal, and psychogenic forms, and is strongly associated with conditions like heart disease, obesity, sleep apnea, and depression, making it a powerful early warning sign that something deeper is wrong While drugs like Viagra can temporarily improve erections, they don't work for everyone and may be unsafe for men taking heart and lung medications Instead of relying solely on pills, addressing root causes with a heart-focused check-up, a metabolic-friendly diet, pelvic floor training, restorative sleep, enough sunlight and mindful supplementation can help restore sexual function without more drugs

Inserted Ad Free Dopey: www.patreon.com/dopeypodcastThis week on Dopey! For our post-Christmas Dopey episode we kick it off with a Christmas gift review and we read Spotify comments on the Alec Baldwin episode we shout out NANA/Lili Coffin hitting 6 years sober, and weaves in sponsor love. The return of White Tighties Jeremy Turner accidentally shooting Viagra and an email all about meth-fueled multi-day porn marathons that destroy skin and phones another about brutal long-term benzo withdrawal horrors, and a wild prison-submitted bath salts tale full of paranoia and fake-reality glitches.Then, at 25:42, Yellow Balloon recovery powerhouse Jen Dawson takes over with her unforgettable Southern story – from feeling like an outsider in a "normal" family, early prescribed Adderall and wild "nipple" psilocybin mushrooms, diving headfirst into '99 Phish tour life, crystal meth insanity, toxic soulmate drama (including a pistol-whipping incident), a venomous spider bite leading to near foot amputation and a pain-clinic fentanyl jackpot, research chemicals, shooting heroin, the devastating stillbirth of her son Dakota, a suicide attempt, multiple jail stints, and finally true surrender in a strict year-long program. Now 11 years sober, Jen shares how sweat lodges helped her connect with Dakota's spirit, rebuilding life with daughter Cyprus (now 18 and thriving), going to college, and finding lifelong community in the Yellow Balloon sober jam-band scene. Raw, funny, tragic, and deeply inspiring – peak Dopey.All That and MUCH MORE ON THIS HIPPY DIPPY FAR THE FUCK OUT NEW EPISODE OF THE GOOD OL DOPEY SHOW! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

RUNDOWN   Did you see Anthony Joshua knocking out Jake Paul in a Netflix spectacle that somehow guaranteed both fighters $92 million? While relieved to see Paul finally get hit for real, Mitch is stunned that global interest was strong enough to justify such an enormous payout for an eight-round exhibition. The segment becomes a blunt look at influencer economics, Netflix's business model, and why modern fame—not boxing legitimacy—now drives sports entertainment. Hotshot relives an on-air argument about whether Andy Gibb was a Bee Gee, while Mitch tells the story of getting yanked off a Syracuse DJ shift for interrupting a song to announce Andy Gibb's death. They pivot to Thursday night's Seahawks win over the Rams—Hotshot admits the overturned two-point conversion still feels "cheap," and Mitch argues the lack of urgency proves Seattle believed the play was designed as a forward pass until it wasn't. The segment ends with Mr. Playoffs logic: even if Seattle grabs the NFC's top seed, the Rams likely become the dangerous 5-seed and could boomerang right back into Seattle's divisional-round path. Ray Roberts joins Mitch for an intense Upon Further Review debate, rejecting the idea that the Rams are clearly better and arguing the two teams are neck-and-neck, winning in different ways. He points to Seattle's resilience, defensive toughness, and locker-room connectedness as unmeasurable traits that data and "eye tests" often miss, especially when a team keeps finding ways to win close games. The conversation drills into the overtime drive, the two-point conversion, Sam Darnold's growth, and whether the real breakthrough may be Clint Kubiak learning how best to deploy his quarterback under pressure. Henderson and Bevens dissect the Seahawks' improbable comeback over the Rams, with both pointing to belief, crowd energy, and elite special teams as the real difference-makers in a game Seattle otherwise struggled to control. The conversation zeroes in on Sam Darnold's fourth-quarter and overtime composure—ugly early, elite late—and whether that drive permanently shifts his ceiling against top competition. They also credit Sean McVay's adjustments for the Rams' offensive surge while arguing Seattle's defense and special teams ultimately tilted the outcome. Neuheisel reacts to the opening round of the College Football Playoff, arguing the Group of Five's lack of competitiveness will force structural change, possibly toward a separate championship or play-in model. He weighs quarterback decisions in the NIL era—suggesting Oklahoma's John Mateer should return to college for a more lucrative year—while breaking down Alabama's escape, Miami's survival, Oregon's dominance, and Ole Miss' surge behind Trinidad Chambliss. The segment closes with Michigan's coaching uncertainty, Neuheisel's skepticism about splash hires, and Taco Time honors for Reuben Bain and Chambliss after standout performances.   GUESTS   Ray Roberts | Former Seahawks offensive lineman; Seahawks Radio Network analyst Brady Henderson | Seahawks Insider, ESPN Jacson Bevens | Writer, Cigar Thoughts Rick Neuheisel | CBS College Football Analyst, Former Head Coach & Rose Bowl Champion   TABLE OF CONTENTS   0:00 | Jake Paul gets flattened, Netflix cashes in, and Mitch can't believe a YouTuber just made $92 million. 11:28 | BEAT THE BOYS - Register at MitchUnfiltered.com 16:10 | Bee Gees radio war leads into Seahawks–Rams controversy, "cheap" two-point chaos, and the nightmare math of a Rams playoff rematch. 39:24 | GUEST: Ray Roberts; Ray Roberts pushes back hard: Seahawks aren't inferior to the Rams—they're built differently and just as dangerous. 1:12:10 | GUEST: Seahawks No-Table; "Team of destiny" vibes, special-teams swings, and whether Sam Darnold unlocked the next level after Thursday's chaos. 1:40:24 | GUEST: Rick Neuheisel; Playoff reality check, transfer-market chaos, and why college football's structure is headed for another reset. 2:05:00 | Other Stuff Segment: UW football transfer portal departures (Adam Muhammad, Radlan Vines-Bright, Bryce Butler), NIL money gap between elite programs and UW, Flyers broadcaster hot-mic suspension, UW men's basketball losing to Seattle University again, Terence Crawford retirement, UW men's soccer national championship, Puka Nacua controversy and apology, Miles Jack arrest and welfare check incident, Johnny Manziel scratched from ESPN GameDay, Dick Van Dyke turning 100, Kristin Cabot Coldplay concert fallout and public statement, college football playoff GameDay guest switch, Seahawks playoff positioning and Rams avoidance scenarios RIPs: Greg Biffle, wife Christina Biffle, daughter Emma, son Ryder Dennis Dutton, son Jack Dutton, and Craig Wadsworth (private plane crash), Rob Reiner and wife Michelle Singer, Gil Gerard (Buck Rogers in the 25th Century), Anthony Geary (General Hospital's Luke), Carl Carlton ("She's a Bad Mama Jama"), Mike Campbell (former Mariners pitcher), Peter Green (Pulp Fiction, The Usual Suspects) Headlines: Trump wax statue removed from Texas museum after repeated punches, First female Viagra-style pill finally released after 30 years, Secretary of State Marco Rubio bans Calibri font at State Department, Woman charged for public sex act at a Winn-Dixie grocery store, Robocop statue installed in Detroit… then stolen.

The holiday season is here and in today's episode we are talking about giving and receiving gifts in your relationship. What does this ritual mean to you and which are you more comfortable with? George and Laurie share their thoughts and some of their favorite gifts and memories over the years. Laurie suggests that partners keep a running list of their loved ones' likes so when it comes time to get a gift you already have ideas handy. It's best if gifts are thoughtful and have your partner feel seen rather than buying something just because. Intentional gift-giving can spark connection and provide lasting memories. On the other hand, gifts that don't consider your partner or create pressure can lead to a negative cycle. What is one holiday gift or ritual that makes you feel good and inspires connection? Share with us on our instagram page! We wish all our listeners a happy holiday season and thank you for your continued  support! We hope you continue to listen in the new year and celebrate as we transition to our new brand Brave Love, Great Sex! Keep it hot and ho, ho, ho, y'all! Check out this episode's sponsors (and help the pod!): RexMD.com -- Reliable, discrete ED support! RexMD offers a simple, private path to get ED meds like Viagra, Cialis, or generics. RexMD is giving up to 95% off during the holidays! Call them today. Uberlube.com -- Laurie's long-time favorite personal lubricant! Simply the best! Learn more about your ad choices. Visit megaphone.fm/adchoices

Episode 1856 - brought to you by our incredible sponsors: Lucy - Level up your nicotine routine with Lucy. Go to Lucy.co/HARDFACTOR and use promo code (HARDFACTOR) to get 20% off your first order. Lucy has a 30-day refund policy if you change your mind RIDGE - Take advantage of Ridge's Biggest Sale of the Year and GET UP TO 47% Off by going to ⁠https://www.Ridge.com/HARDFACTOR⁠ #Ridgepod DaftKings - Download the DraftKings Casino app, sign up with code HARDFACTOR, and spin your favorite slots! The Crown is Yours - Gambling problem? Call one eight hundred GAMBLER Timestamps: (00:00:00) - NBA Jam and NBA Jam TE were so good, and 1856 was a big year for Dallas (00:10:07) - More mass shootings by psychopaths at Brown University and Boni Beach Hanukkah Celebration (00:24:57) - SCAMS - Which One's Worse: Congo Collapsing Bridge for $2M, or Messi Appearance in India turned riot?? (00:38:27) - Viagra for Women, literally the same drug works for them in lotion form, is finally being offered almost 30 years after viagra for men Thank you for listening!! Go to Patreon.com/hardfactor to join our community, get access to bonus pods, discord chat and much more - but Most Importantly: HADFD!! Learn more about your ad choices. Visit megaphone.fm/adchoices

Not satisfied with the traditional ‘agony aunts' tag line, you have come up with some hilarious (and slightly offensive) alternative names for William and Jordan. The boys also review the most iconic songs in musical theatre, the ins and outs of Viagra (no pun intended) and finish off with a large helping of Dick (Van Dyke) chat.If you want to get involved you can email us, and for more Sexted fun sign up to our free VIG&Diva newsletter. You can follow us and DM on Instagram and TikTok, and watch the latest episode every Tuesday and Friday on YouTube.Help I Sexted My Boss is presented by William Hanson and Jordan North. It is an Audio Always production. Hosted on Acast. See acast.com/privacy for more information.

LightSpeed VT: https://www.lightspeedvt.com/ Dropping Bombs Podcast: https://www.droppingbombs.com/   In this thrilling episode of Dropping Bombs, TikTok sensations Kaz Sawyer and Jalyn Handley—who boast over 20 million combined followers across platforms—reveal secrets on going viral, building empires, and wild encounters that could change everything. From Kaz's infamous Viagra prank that skyrocketed him overnight to Jalyn's emotional search for his biological family that hooked millions—these guys reveal the raw strategies behind their success.These aren't your typical influencers, they're entrepreneurs leveraging massive followings to build real businesses.   Discover why consistency beats perfection, how to turn followers into customers, and the mindset shift from brand deals to building empires. From Jaylyn's 30-person team and international supply chain to Kaz's music licensing agency pulling six figures monthly, they reveal strategies most creators never consider. Ready to stop being an employee and start building generational wealth? This raw conversation destroys every excuse keeping you from creator-level income.   Kaz's Links