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Dr. Deb Muth 00:00:09 Hi there, how are you? Bob Miller 00:00:10 Excellent! Pedaling as fast as humanly possible, but doing okay. Dr. Deb Muth 00:00:14 Good, good. Well, I’m looking forward to our conversation today. This should be amazing. Bob Miller 00:00:20 Yeah, it should be a lot of fun. Dr. Deb Muth 00:00:22 Yeah, anything that’s off-limits for you in, our conversation? Bob Miller 00:00:28 No. Dr. Deb Muth 00:00:29 Okay, anything you want me to make sure we cover for you? Bob Miller 00:00:33 Well, I mean, is it okay if we put a little plug-in for our software? Dr. Deb Muth 00:00:35 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:36 Yeah. Dr. Deb Muth 00:00:37 Absolutely. Bob Miller 00:00:38 Hey, can we… can we do a screen share? Yes, we can. Yeah, because I want to show you some maps, and… Dr. Deb Muth 00:00:43 Okay. Things like that, yeah, so… Perfect. So just let me know when you want to do screen share. Bob Miller 00:00:48 Okay. Dr. Deb Muth 00:00:49 And yeah, feel free to plug your software wherever you want to. Bob Miller 00:00:53 Okay, well, good. Let me pull up a, a slide for that, and give me one second, I just want to shut the door to my office to get the noise down. Dr. Deb Muth 00:01:01 No worries. Bob Miller 00:01:16 And, how should I refer to you? Dr. Debb? Dr. Muth, what do you like? Dr. Deb Muth 00:01:18 Dr. Deb is great, or Deb, either way, I’m pretty informal, so… Bob Miller 00:01:22 Yeah, and… Bob is fine for me. Okay. Yeah. Yeah, there you go. Why people feel like they need this, son. Special name, it’s like, seriously. Dr. Deb Muth 00:01:33 Right? I agree. Bob Miller 00:01:35 When I work with my clients, it’s like, Dr. Millison, just, just bop, just, just bop. Dr. Deb Muth 00:01:41 Yep, that’s how I am, too. Just call me Deb, it’s good. Dr. Deb Muth 00:01:44 They feel a little awkward with that, you know? They’re not used to that, but… Bob Miller 00:01:48 Alright. And you’re a naturopath, medical doctor. Dr. Deb Muth 00:01:52 A nastropathic doctor and a nurse practitioner. Oh, nice. Yeah, so I got the best of both worlds, right? Bob Miller 00:01:58 Yeah, damn. Okay. Alright, so here we go… There we go. Alright, so I got that ready, and then I will do a, I will do a screen share. I think you’re gonna really, appreciate what we’ve come up with. We’ve come up with the concept of, Cellular CPR. Dr. Deb Muth 00:02:23 Oh, nice! Bob Miller 00:02:24 And that is, construct the cell membrane, Protect the cell membrane. And restore it if it’s damaged. Dr. Deb Muth 00:02:32 Love that. Bob Miller 00:02:34 I love that. Yeah, so that’s what we’re focusing on, and then how, You know, we want to get to the point that, you know, most people think of genetics, they think of, like, 23andMe or Ancestry. Dr. Deb Muth 00:02:44 Yeah. Bob Miller 00:02:45 And then you have the professional geneticists who are looking at, you know, odd things that could create a disease. We’re looking at functional genomics. Dr. Deb Muth 00:02:54 Which is so much better. Bob Miller 00:02:56 Yeah. Are you familiar with what we do here, or… Dr. Deb Muth 00:02:58 A little bit, a little bit. So, it’ll be new to me, too, so I’m excited. Bob Miller 00:03:03 And how much time do we have? Dr. Deb Muth 00:03:04 We have an hour, give or take a little bit on either side. Do you have a hard stop anywhere? Bob Miller 00:03:10 No, no, I put a, I moved my clients around, and I don’t have anybody till, 3.30, so we’re good. Okay. Dr. Deb Muth 00:03:16 Perfect. Alright. Bob Miller 00:03:18 It’s like we’re getting started early as well, so… Dr. Deb Muth 00:03:19 Yeah, we’re getting started a little bit early, so that’s good. Bob Miller 00:03:22 Yeah, I just got my office cleaned up, so… Dr. Deb Muth 00:03:23 Okay, good. All right, are you all set to get started? Bob Miller 00:03:28 I’m good to go, my friend. Dr. Deb Muth 00:03:29 I’m gonna just record a little intro and a little bit of a, hook for people, and then we’ll get started. I’ll ask you to kind of tell us a little bit about yourself, and then we’ll just take this conversation wherever it’s supposed to go. Bob Miller 00:03:39 Okay, you got it. Dr. Deb Muth 00:03:40 Alright, sounds good. So what if the reason you’re not healing isn’t your diet, your supplements, or your labs, but it’s actually your genes? Dr. Bob Miller is uncovering how genetic variants, when combined with modern toxins, explain why some of us stay sick no matter what we try. Today, we’re talking genetic pathways, detox blocks, and the new science every wellness warrior needs to know. Welcome back to Let’s Talk Wellness Now, the show where we uncover the root causes of chronic illness, exploring cutting-edge regenerative medicine, and empower you to heal from the inside out. I’m Dr. Deb, your medical detective, and today, our guest, Dr. Bob Miller, is a true pioneer in functional genomics. He’s a board-certified traditional naturopath and the founder of Neutrogenetic Research Institute. And he’s the leading groundbreaking research on how genetic variants influence chronic illness, inflammation, and detoxification. His work has been recognized on international stages, uncovering links between genetic expression and conditions like Lyme disease, mast cell activation, or MCAS, and mitochondrial dysfunction. I’m so excited to talk to Dr. Bob today. He is gonna reveal some things that even I don’t know about, so I’m excited to learn alongside of you guys. So… Dr. Bob, let’s get started. Tell us a little bit about yourself, and kind of how you got on this journey. Bob Miller 00:05:04 Well, that’s, that’s interesting. I was sort of like a mid-career coming to the natural health field, because in my early 30s, I found myself with a severe case of ulcerative colitis. Bob Miller 00:05:15 And I was in the hospital for 21 days. probably within hours of death, pleading to death. And they told me I’ve got one option, and that is cut out the colon and wear a bag. Didn’t sound like a lot of fun. Dr. Deb Muth 00:05:27 Not an option I would want. Bob Miller 00:05:29 So, you know, the medical folks wasn’t real happy with me, but I said, yeah, I’d like to explore some alternative things.Never thinking that I’d get into this field, and then I just, you know, worked with some herbalists and things that I found absolutely fascinating. So, that’s how I got into this around 30 years ago. And, haven’t looked back since, and just having a… having a blast as we now move into how our genetics impacts things. So, that’s what we’re gonna… that’s what we’re gonna talk about today. Dr. Deb Muth 00:05:58 I’m excited to talk about this genetic thing. When you started over 30 years ago, what kind of patience and problems first inspired you to dig deeper into that root cause healing and kind of get into the genetic piece of it? Bob Miller 00:06:10 Sure. Well, you know, as a… now, I’m in a part of the country called Lancaster County, Pennsylvania, where there’s a lot of Amish and Mennonite, and they gravitate towards these things.So, this is their first thing to do, and that doesn’t work, then they’ll go other routes. So, you know, back then, we just saw typical, you know, a little tired, constipation. You know, a little bit of fatigue, arthritis, those kind of things. But things have changed dramatically over the years, as people are now getting more chronically sick. You know, it’s worse than it’s ever been. And what we’re finding is the, the culprits Primarily is mold exposure and Lyme disease. When people get those two together, they’re just… it’s an inflammatory cascade that nobody can seem to unravel. So that’s where we spend a lot of our time. And we’re also spending a lot of time looking at mental health, like ADD, ADHD. And, we give… this year I’ll be speaking at three autism conferences. And we can dig into that a little bit as to why we think we’re seeing such a dramatic increase. And aside from autism, that used to be 1 out of 1,000, now it’s 1 out of 33, or 23. You know, we’re also seeing dramatic increases in ADD, ADHD. People are stressed out. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. And today, I think we’ll have the time to actually go through and show how environmental factors combine with genetics to cause that to happen. So we’ll… we should have a fun visit here today. Dr. Deb Muth 00:07:37 This should be a fun visit. We can cover lots of topics. I am so excited. So, you founded Nutri Genetic Research Institute in 2015. What did you hope to accomplish, and what kind of surprised you in your findings so far about that? Bob Miller 00:07:51 Well, you know, let’s back up at what, you know, genetics is used for. Everybody’s familiar with 23andMe and Ancestry that, you know, tells you where your ancestors came from. Then you have your professional geneticists. I mean, these are people with a degree in genetics. And they’ll look for, you know, very odd sort of things that are prone to relate to a disease. So there are disease-related genetics. Well, in functional, we don’t look at either of those. We look at For example, how you’re breaking down your fats and utilizing them. How you’re recycling your glutathione. How you might be handling your iron. And none of those are disease-causing on their own.And none of those are disease-causing on their own. But when they pile up on you, and then combine that with environmental factors, that’s when things start to go south on us. So, that’s what we’re doing, we’re looking at patterns. And our first foray into this was, we did studies on Lyme disease. And our first foray into this was, we did studies on Lyme disease. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. So, we looked at, like, I think 50 people with Lyme disease. We looked at their genome. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. And we found patterns that were more evident in those with Lyme. Now, this doesn’t… these genetics don’t mean you get Lyme, it just means if you get Lyme, you react worse to it. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. So, as you know, some people get Lyme, they go on a round of antibiotics, and they’re done. Others have a little more struggle, and then others are struggling terribly for years. So there’s an old adage of genetics loads the gun, environment pulls the trigger. Dr. Deb Muth 00:09:14 Yeah, that is so true, and I think when we’re talking about Lyme and mold and things like that, we forget sometimes that our genetics can predispose us to be more sensitive to those things, and if we have genetic pathways where we don’t clear things properly, it’s harder for us to get them out of the body. And then you add on that whole rain barrel effect that we’ve always used as a functional medicine term, right? If the barrel’s half full, you’re okay. If it’s full, and now it’s spilling over, it’s a bigger problem. Have you guys found, too, that some of these environmental things actually are changing the genetics of people, or how they’re processing their own genetics? Bob Miller 00:09:53 Well, let’s go back to, Genetics 101. But we’ll go back a little bit further. So, what an interesting mechanism, what a miracle the body is. Bob Miller 00:10:03 Fats, carbohydrates, proteins, drink water, breathe air, expose the sunlight, and somehow everything gets made. I mean, when you just step back and think about that, it’s like, It’s pretty darn amazing. Dr. Deb Muth 00:10:15 I always tell women, you know, the fact that we get pregnant and we have healthy pregnancies and births is a miracle, because if we had to try to control that, that wouldn’t work so well. Bob Miller 00:10:25 Right. Well, that’s another miracle. These microscopic sperm and egg, human being, 9 months later, it’s like. But even inside of us. We are making our hair, our skin, our nails, our blood vessels, our ATP, our energy, it’s all being created. Well, that gets created by enzymes. So, enzymes take one substance, combine it with something else, and make something new. Then another enzyme comes along and does the same thing. Your DNA is the instructions on how to make the enzymes. So, when we are conceived. If it’s a, if it’s a female, of course, it’s the XX, the two chromosomes. You know, we’ve… everybody’s seen those… the genetics that… Listed pair. So, if it’s a female, the father donated the X enzyme. And the mother has no choice but to give the eggs, so that’s female. If the father donates the Y, you have a male that’s in chromosome number 1. Then 2 through 23 is the rest of the instructions on how to make enzymes. So, what can happen? We can get what are called SNPs, single nucleotide polymorphisms. And SNPs just mean that the instructions to make the enzyme’s not quite as good. So, if one parent gives a SNP on the making of an enzyme, The enzyme’s fine. It works. But, general rule of thumb, It may only work at 70-80% of efficiency. Now, a good analogy is think of an 8-cylinder and a 6-cylinder car. If parents give you good information, that’s like having an 8-cylinder car. If one parent gives you that snip, it’s like having a 6-cylinder car. Now, is a 6-cylinder car a fine car? Sure. It’ll get you from point A to point B, but it’s just going to have the power of an 8-cylinder. Then if both parents give you a SNP on the same enzyme, it may be 30-40%, and that’s like having a 4-cylinder car. Sits in the driveway, looks the same, puts gas in it, everything. But if you’ve got a 4-cylinder car. Probably not a good idea to go cross-country pulling a trailer behind you up and down mountains. Dr. Deb Muth 00:12:29 This is true. Bob Miller 00:12:32 So… We can get an 8-cylinder, 6-cylinder, or 4-cylinder enzyme. Now, if it’s not under a lot of stress, if that 4-cylinder car is just taking you to the bank and the grocery store. It’s just as good as an 8-cylinder car. But if you gotta pull that trailer, and there’s a lot of stress on it, being mountains, it’s gonna struggle. Now, there’s one other little caveat to this, and that is some genetic mutations are gain-of-function. They actually work faster. Now, we have enzymes that do all kinds of things. We have enzymes that make and recycle our antioxidants, but we also have enzymes that make inflammation. No, that’s a good thing, because if we get a virus or bacteria, if you didn’t make inflammation to kill it, well, we’d all die of infection. So, you know, we tend to think of free radicals as bad, antioxidants as good. They both play an important role. But interestingly, some of the major enzymes that make inflammation, they can be overactive. They can be turbocharged. And when they’re stimulated by environmental toxins, they overreact. Bob Miller 00:13:40 And therein lies the problem. When they overreact, we have a problem. Bob Miller 00:13:46 So, if we have genes that overreact when stimulated. And then the enzymes that take care of inflammation are underactive. Then you’re gonna be more inflamed. You know, the majority of people that, you know, come for functional medicine Or naturopathic help, or… Inflammation that they can’t seem to get under control. Dr. Deb Muth 00:14:06 Right. Bob Miller 00:14:07 And we will be, you know, during this hour, we’re going to look at some of the pathways that make that happen. So, what we can do then, we can’t change our genetics. When you’re conceived, that’s the hand you’re dealt. When your life would be over, if someone would take some tissue and measure, it’d be exactly the same as conception. Does it change. Bob Miller 00:14:28 The enzyme’s ability to do its job may be compromised. Because remember I said there’s a, the enzyme takes a cofactor. So an enzyme takes substance A, cofactor, make substance B. Well, if that cofactor’s not there, the enzyme’s not going to work either. So, you could have an 8-cylinder car, and if there’s no gas in it, it’s not going anywhere. So… It’s the strength of the enzyme, it’s the cofactor to do the A to B conversion. And that’s what we’re going to get into. So, many people say, well, where did these SNPs come from? Nobody knows for sure. Sometimes they’re what’s just called de novo, when the sperm and egg go together, the instructions get mixed up a little bit. We do believe a lot of it came from a long time ago, when we were almost wiped out by sexually transmitted diseases. And those STDs were altering the genes when the conception, in other words, when the sperm went into the egg, the STDs were interfering. And causing the problem, so… I often joke, if you want to blame somebody. Blame your great-great-great-great-great-great-great-grandparents for, being a bit promiscuous, so… Dr. Deb Muth 00:15:31 Yeah, for being… having a little too much fun, right? Bob Miller 00:15:35 So, we don’t know for sure, but, you know, there are some that, But most of the SNPs that we get inherit from our parents. So, if you look at a child. And you look at the SNPs. 99.9% of the time, it came from one of the parents. Dr. Deb Muth 00:15:50 In identical twins, do they have the exact same identical makeup? Bob Miller 00:15:54 Yep, Dr. Deb Muth 00:15:56 But not in fraternal twins, correct? Bob Miller 00:15:59 No, no, those could be different, Jeff. Dr. Deb Muth 00:16:00 It could be different because they have different sacs, they’re not sharing that same genetic makeup. Bob Miller 00:16:04 Yeah, so keep in mind, both your mother and your father have, you know, the two And so you get one from one parent, one from another. Dr. Deb Muth 00:16:13 So… Bob Miller 00:16:14 Interesting situation. I had, 3, 3 boys. And, we were looking at an enzyme related to breaking down oxalates. Now, the mother and father each had one SNP, and that’s called heterozygous. Three boys, and they all come together, they’re Amish boys, they’re a lot of fun. And I looked at their genomes, and the one boy didn’t have any SNPs at all. And one had won. And the other one had two. Dr. Deb Muth 00:16:41 Interesting. Bob Miller 00:16:42 So, we don’t quite know how these things get handed off, but with the parents each having one, you could have a child with none, one, or two. So, the one, his ability to break down oxalates, which is fine. The other one was slightly impaired, and the other one was dramatically impaired. So, you can have 3 children, and it all depends what the parents have. Now, if a parent has a homozygous, or 2 copies. And the other parent has nothing. Every child will have one. Okay. If both parents are homozygous, that they both have two, Every child will have two. Dr. Deb Muth 00:17:19 too. Bob Miller 00:17:20 Yes, so that’s the way it works, but, you know, but it’s somewhat rare that both parents are homozygous on an enzyme, but it can happen. Dr. Deb Muth 00:17:27 Do we think that infections today, like Lyme disease or mold exposure, things like that, if the parent, the woman, primarily, I’m thinking, is pregnant, and she actively has these infections. Can those infections affect the genetics, kind of like a past sexual transmission did where we thought back in the day? Bob Miller 00:17:47 Yeah, I… I mean, I’m not that much of a geneticist to answer that for sure, but my thought would be no, that at conception, the pattern’s made. Dr. Deb Muth 00:17:55 Okay. And then that’s… that’s the hand you’re dealt. Bob Miller 00:17:58 Yeah. So, I tell people we have good news and bad news. The good news is we can compensate for the weakness. The bad news is we can compensate for the weakness. Dr. Deb Muth 00:18:09 That is so very true. Bob Miller 00:18:11 Yeah, we can’t, because I often get asked, so we’ll do some things now, and we’ll check my genes again, and they’ll be better. It’s like, nope. Dr. Deb Muth 00:18:18 Oh, – – Bob Miller 00:18:19 You gotta play the hands you’re dealt, so… Dr. Deb Muth 00:18:21 That’s right. Bob Miller 00:18:22 You can test your genetics… if you’re looking at the same enzyme, you can test it every year. It’s not gonna change. It’s like the blueprint. Dr. Deb Muth 00:18:30 It’s good and bad, right? It’s the one test you only have to do once in your lifetime. Bob Miller 00:18:34 No, unless, you know, like, our. Dr. Deb Muth 00:18:36 All the time. Bob Miller 00:18:37 Yeah, now our test looks at, called the Functional Genomic Analysis Test of your genomic Resource. We look at 220,000 steps. Dr. Deb Muth 00:18:46 Wow, that’s a lot. Bob Miller 00:18:47 That’s not all of them. Dr. Deb Muth 00:18:49 Right. Bob Miller 00:18:50 So, maybe in the next year, we’re gonna come out with our third version of the chip. And then, if someone wants to get those new things that weren’t on it, they’d have to repeat. But whatever we measured is gonna stay the same. Dr. Deb Muth 00:19:03 That’s a lot of SNPs to look at. Bob Miller 00:19:05 Keeps us busy. Dr. Deb Muth 00:19:06 But there’s still, but there’s still SNPs that we. Bob Miller 00:19:09 That we’d like to have that we don’t have, so… Bob Miller 00:19:11 We started out with version 1 on our genetic test, then we worked with version 2, and we’re already compiling a list of what version 3 would look like. So if somebody has our version 2, And we’re saying, you know what, it’d be nice if we could see these, well, then you’d repeat, but it won’t change what you already know, so… Dr. Deb Muth 00:19:29 Got it, got it. So, when you started out, and you started looking at the research of Lyme disease and chronic infections, which detox pathways are most important for people who struggle with those conditions? Bob Miller 00:19:43 Okay. You know what might make sense as we do a screen share, and I’ll actually show you the pathway. Does that make sense? Bob Miller 00:19:48 Alright, so… let’s see if I… let me just press the share… Dr. Deb Muth 00:19:52 Yep, you should just be able to press share. Bob Miller 00:19:54 And… number 2. Okay. Are we seeing the screen there? Bob Miller 00:20:01 Okay. Dr. Deb Muth 00:20:02 So, this is a map that we made. Bob Miller 00:20:05 And by the way, this is not… All-inclusive of all the things we look at, but we believe this is a core issue. So, where we’re going to start here, there’s something called the microglia. And the microglia are glial cells. They’re in the brain and the central nervous system. And they’re very interesting little creatures, because most of the time, and this is just a drawing of what they sort of look like. Most of the time, they’re in what’s called the M2 anti-inflammatory mood. What that means, these little guys pick up dirt, debris, Recycle them. Turns on an enzyme called interleukin-10 that’s anti-inflammatory. And just kind of does general housekeeping. And just kind of does general housekeeping. However, when a trigger comes along. However, when a trigger comes along. They… it’s the same glial cell, but it moves over to a very pro-inflammatory enzyme. A pro-inflammatory glial cell. And it triggers these 3 enzymes, Actually, these four. That are pro-inflammatory. Tumor necrosis vector alpha, Interleukin-6. NF Kappa B, Inos. Now, these create inflammation. So you might think, well, why is that good? Well, if you have some foreign invader, virus, bacteria coming in, parasite. If you didn’t have these guys coming to the rescue, you would just die of infection. So, these guys are your friend unless they’re your worst enemy. Because TNFA, and we’ll show you when we actually do a demo account, TNFA can be overactive. So, in other words, it over-responds. Interleukin-6 can be overactive. And if Kappa-B can be overactive. The INOS, and I’ll explain each of these as we go through a demo, can be overactive. Now, what that means is, you’re very good at killing virus and bacteria. But this is where autoimmune disease comes in, and just inflammatory conditions. Now, this is just speculation, but we think what happened is, as you know. Thousands of years ago, we didn’t have refrigeration, we didn’t have sewer, we didn’t have pure water, and we didn’t have antibiotics. So, if you made it to 40, you were an old-timer, because everybody was dying of infection. So, what we believe happened is, by what’s called natural selection, Having these overactive. A thousand years ago was to your advantage. Dr. Deb Muth 00:22:31 Hmm. Bob Miller 00:22:32 But now… We have pure water, we have refrigeration, we have sewers, we have antibiotics. But now we have environmental factors that are stimulating them. Now it’s to our disadvantage. And we’ll talk about that a little bit as it relates to the hemochromatosis genes and maybe the G6PD. Dr. Deb Muth 00:22:48 Yep. Bob Miller 00:22:49 Now, why are we becoming so inflamed? Let’s look at the triggers. Now, one of my, favorite expressions is. I was born all the way back in 1954. Dr. Deb Muth 00:23:01 And it was a different world back then. Bob Miller 00:23:05 These are some of the triggers. And we’ll get into these, but right now, high fructose corn syrup, And the high-fat diet. High fructose corn syrup only came about in 1968. So now we’re being exposed to high fructose corn syrup. Then… we didn’t have these, these viruses like COVID. Dr. Deb Muth 00:23:26 Yeah. Bob Miller 00:23:27 Now, there’s now pretty strong evidence that COVID Was actually, you know, made as a gain of function. It’s debated, and I’m not taking an opinion on it, but there’s some people who believe Lyme disease was also a part of experimentation. Dr. Deb Muth 00:23:40 Go. Bob Miller 00:23:41 Then we have molds, and it appears as though mold is getting stronger. you know, 20 years ago, when I was seeing folks, mold wasn’t on the radar. I would say 7 out of the 10 folks we speak to today have mold problems. Yeah, 20 years ago, we talked more about mold allergy being an issue versus mold toxicity being an issue. Right. So… I know some folks are, you know, speculating what’s happening, but one of the theories out there is that EMF is strengthening mold. I don’t know if you ever heard that theory, and I don’t… Dr. Deb Muth 00:24:13 I have. Bob Miller 00:24:14 I’m not claiming it’s true, but it’s an interesting theory. Then even, you know, your black mold from water-damaged buildings. Then our air pollution is getting worse. We’re getting more toxic metals. Dr. Deb Muth 00:24:26 You know, if we have a… Bob Miller 00:24:27 You know, we’re gonna look back someday and say, what were we thinking, smearing aluminum into our armpits? The, what were we doing putting mercury in our teeth? Then, you know, glyphosate. When I was a kid, there was no glyphosate. So, all of these herbicides and pesticides. Polychlorinated biphenols, And then EMF. So, we love our cell phones, you know, and I think unless you, or in the middle of the desert, or down in a cave, you’re being exposed to EMF somewhere. So, you know, we have our cell phones with us, we have, We have Wi-Fi, the towers are everywhere. And we don’t know long-term, but we may find that this can… this creates some inflammation. And I don’t know if you get any folks, but do you have any folks that have… are they EMF sensitive? Dr. Deb Muth 00:25:16 Oh yeah, we have a whole bunch of them. Bob Miller 00:25:18 Yeah, and then if you have any TBIs, So, plenty of things here. that will stimulate into the microglia, M1. Now, you could say, well. We’re all pretty much exposed to the same thing. Why do some people get hit harder than others? So here’s where we’re gonna start. There’s an enzyme called Nrf2 and RF2. And Nrf2 is the enzyme that senses when there’s inflammation. And turns on hundreds of anti-inflammatory enzymes. We’ll show when we do the demo, you can have genetic weakness on NERF2. And NERF2 inhibits and slows down microglia M1. supports M2. Now, if it’s not complicated enough, there’s an enzyme called KEEP1. And KEEP1 inhibits NRF2. And you can actually have gain of function on keep 1, that makes Keap 1 stronger. So… A lot of the people who land on my doorstep So… A lot of the people who land on my doorstep Both parents gave a mutation on KEEP1, making it overactive. Both parents gave a mutation on KEEP1, making it overactive. Dr. Deb Muth 00:26:31 Hmm. Dr. Deb Muth 00:26:31 Hmm. Bob Miller 00:26:32 Suppressing Nrf2, nerve 2 might be weak. So, nobody’s putting the brakes on, M1. And by the same token, Nerve 2 supports M2. Then there’s a process called mTOR and autophagy. mTOR stands for mammalian tard of rapamycin, the growth of new cells. And then autophagy, taking our dead cells and recycling them. We need a balance between the two of them. If we didn’t have mTOR, the sperm and the egg would never become the baby, the baby would never become the adult, we wouldn’t make new cells. But our cells are constantly, you know, the old cells dying off. Autophagy is where we take that debris from the cell and recycle it, just like a farmer Plows the crop under at the end of the year. The dead plant then becomes the fuel for the spring, your dead cell becomes the fuel for the spring, and that’s autophagy. So we’re gonna look back someday and say, what were we thinking? We give our animals growth hormones so they get fatter faster. Oh my. So, we consume those animals, and inventory runs faster. Now, for anybody who’s, You know, maybe above 40, 45 years old. Think back when you were 12, and what did girls look like? They were primarily flat-chested little girls. Now they look like 16-year-olds. Because environmentally, we’re jacking up mTOR. So, mTOR stimulates microglia M1, suppresses microglia M2. Probably 80% of the folks we visit with. This is the part of the problem. NRF2 is weak. mTOR is strong. Environmental factors come along. And this guy gets carried away. He doesn’t do that burst and move back. Stays here. We’re calling that How environmental factors create a locked-in, pro-inflammatory. and neurotoxic phenotype. In other words, once it starts, it just keeps… Feeding upon itself. Alright, so what happens now when microglia is overactive. it triggers these 3 enzymes, TNFA, N of kappa B, And interleukin-6. Each one of these can have genetics that make them run stronger. Then it stimulates an enzyme called NLRP3, Which makes what are called inflammasomes. Now, guess what inflammasomes can be? Your best friend or your worst enemy? Because they will, if you’ve got, again, a virus or bacteria, or possibly even some bad cells in the body. They will zap them. Well, that’s good. Unless it’s overactive. Unless it’s overactive. And then what it does, through interleukin-1 beta, makes excess glutamate. And then what it does, through interleukin-1 beta, makes excess glutamate. Anxiety, gut inflammation, OCD, ADD, autism. And, you know, glutamate, we’ll talk about that a little bit, but glutamate makes you intelligent, highly motivated go-getter. but can also be excitatory. And then, look what it does. Let’s see, do I have the drawing tool here? Yes, I do. Okay. So, it comes down through here, Makes the glutamate. Comes back up through here. through the ADORA 2A enzyme, Then we’ve got a feedback loop that feeds upon itself. Then, through interleukin-18, we make histamine. and mast cells. And then through histamine receptor site number 1, we come back and spin it. And now you’ve just got this spinning feedback loop. So, the glutamate will make you anxious, the histamine will give you allergies and make you anxious. And you’re allergic to everything, and you’re feeling horrible. Now, it doesn’t end there, Dr. Dad. It then goes on to make something called gast dermins that creates pyroptosis, where it actually starts punching a hole in the cell membrane. And you’re only going to be as healthy as your cells are. Just a little background. You know, we’re made up of trillions of cells, and each one of them has what’s called a lipid bilayer, made from lipids, which comes from fats. And you’re only going to be as healthy as those membranes are. So that’s why we coined an interesting phrase. Cellular CPR. Construct the cell. Protect the cell. And restore the cell membrane. And we believe that’s going to be revolutionary in the functional medicine world. So… It’s not hard to figure out that if you start punching holes in the cell membrane, that’s not a good thing, okay? Bob Miller 00:31:22 Now… There’s an interesting molecule called NAD. Thicotide adenoside dinucleotide. And anybody who’s in the, you know, listening to the health podcasts and things, they’re… They’re, they’re learning about NAD. And I’m going to show you a chart later, all the good things that NAD does, but For the most part, it helps what’s called sirtuins. And sirtuins are quite interesting. If anybody’s looking at longevity. The sirtuins is where they’re looking at.Because sirtuins turn on good things. Turn off bad things. And I’ll show some charts on that later. So for right here, this sirtuin uses NAD, to slow down NF-kappa-B. CERT 2 uses NAD to slow down an ORP3. So, if we’ve got genetic weakness on these, or we don’t have enough NAD, We don’t hold this pathway back. Make sense? Dr. Deb Muth 00:32:24 Yeah, makes perfect sense. Bob Miller 00:32:25 Now, I’ll show this a little bit later. So, people are like, oh, well, I’m gonna start taking some NAD. Dr. Deb Muth 00:32:31 Right. Bob Miller 00:32:32 And there’s functional doctors who give NAD intravenous. It was just this morning, I was talking to a woman who said, Oh my gosh. I went and got intravenous NAD, and it took me a month to recover from that. Dr. Deb Muth 00:32:45 Hmm. Bob Miller 00:32:46 what happens is, and I’ll show this in a little more detail, there’s an enzyme called CD38, that’s stimulated by NF-kappa-B. And it takes NAD, To make intracellular calcium. that stimulates NLRP3 and actually makes things worse. So, if we have this guy upregulated, and I’ll show a chart what does that. taking NAD will make you worse. Again, when I go into the software, I’ll show you that whole pathway, so… I would encourage people, you know, just don’t go out and start taking massive amounts of NAD, you know, stick your toe in the water, see how you do. Because everything you’ve heard about, how good it is, is true, unless this guy says, oh, thank you very much, let me make more inflammation. Now, this might be part of our innate immune system, that if we have some pathogen that’s gonna kill us. By golly, we want that to happen. But if this is happening by environmental factors, Then it’s detrimental. So the immune system that protected us a thousand years ago now might be turning on us because of the environmental factors that we showed earlier. All right. Then there’s an enzyme called PARP that’s NAD-dependent, and that actually repairs strain breaks in your DNA. Now, the next thing that happens… is there’s an enzyme called NADPH oxidase that gets stimulated. and something called INOS. Now, I’m sure most people know about nitric oxide. It’s a gas that dilates your blood vessels. That’s why sometimes they’ll even give people drugs, nitroglycerin, to boost their nitric oxide. That’s why people are doing beetroots and other things to boost their nitric oxide. But there’s an OS3 enzyme that makes the nitric oxide that’s good for blood flow. But there’s an INOS That makes nitric oxide to kill pathogens. probably might be the third or fourth time I’ve said this. That’s a good thing, unless it isn’t. So, if it’s killing some pathogen, great. It was just misfiring. it combines… With superoxide that’s made by this enzyme, and makes something called peroxynitrite, which is one nasty free radical that chews you up and spits you out. So, the NOx enzyme, NADPH oxidase, uses NADPH, To make this free radical called superoxide. If we have time, we’ll get into it. NADPH is what your body needs to recycle your antioxidants.So, I coined the phrase, the NADPH steel. Where the NOX enzyme takes this very important NADPH, And rather than being useful, makes superoxide. Now, again, is that fine if you’ve got some bacteria to kill? Of course. But if it’s just chronically running, it’s just making all this chronic inflammation. Then it makes something called hydrogen peroxide. And we need to clear hydrogen peroxide by 3 enzymes, catalase, thyroid reduction. And glutathione peroxidase. If we have genetic issues on here, or we don’t have the cofactors. There’s something called the Fenton reaction, discovered in 1895 by Dr. Fenton. Where hydrogen peroxide combines with iron to make what are called hydroxyl radicals. And guess what they do? They create lipid peroxides, That damages your cell membranes. Now, again, the body’s pretty darn amazing. We have glutathione, And here’s where your body’s taking glutathione and recycling it. But look who’s needed to recycle it. NADPH. So, if this guy up here is chewing it up, We don’t recycle our glutathione. And then an enzyme called glufon peroxidase 4, Takes this damaged lipid and repairs it. So, here we’ve got this protecting, we want to protect it by not having this happen. But then we also need this guy to do the restoration. So, there’s a lot that can go wrong in here, Dr. Deb. Dr. Deb Muth 00:37:07 There’s a lot that could go wrong. And I can imagine some of my listeners are thinking that lipid peroxidase, is that the same thing as what they’re thinking of when we talk about lipids and cholesterol? Is that the same process that’s happening there? Bob Miller 00:37:22 Well, no, no, the lipids can be used to make cholesterol, but here we’re talking about where they’re going to build the cell membrane. And they’re being… and they’re being, destroyed. If anybody would like to see a visual representation of this, just go on YouTube. And type in, ferrooptosis Animation. cool little video, it’s about 3 minutes long, and it shows the lipids coming over, being oxidized, and now GPX4 fixes them, so… YouTube, Pharaoptosis Animation, cute little video. It’s just that really… Shows vividly what we’re… what we’re talking about here. Now, this is… Dr. Deb Muth 00:37:59 And so this is very common, too. Like, a lot of people do hydrogen peroxide IVs. Dr. Deb Muth 00:38:04 And so, if somebody doesn’t know their genetics, they could have a problem with doing those, just like they could doing the NADHIVs, correct? Bob Miller 00:38:13 Sure, yeah, yeah, yeah. So, I’ve talked to so many, you know, of course, the hydrogen peroxide kills pathogens. I mean, that’s what it does. So… but I’ve spoken to so many people that said. I had one client that said they’ve never been the same after having one hydrogen peroxide infusion. Dr. Deb Muth 00:38:30 Interesting. Bob Miller 00:38:31 Yeah. So… it can be… I see why people use it, because it. Bob Miller 00:38:36 pathogens, But on the other hand. And now’s a good time to speak about… I don’t have it on here, but there’s a, there’s an enzyme called the HFE gene. And that is what causes you to absorb iron. And there’s mutations in it that cause something called hemochromatosis. Were you overabsorb iron? Now, true hemochromatosis is when both parents give you a mutation. But there’s now growing evidence even a heterozygous can cause a little bit more iron absorption, not to the human chromatosis point, but overabsorption. So, if you overabsorb iron, And you have too much hydrogen peroxide that’s not cleared, All kinds of inflammation. Now, what’s happened is sometimes this inflammation Will damage the red blood cells. And some well-meaning doctor says, oh, you need some iron. And they take iron and it makes it worse. So, can’t tell you how many people I’ve said, you’ve got the overabsorption of iron, and they say, well, that can’t be right, because I’m low in iron. Well, that could be because it’s being chewed up here. Dr. Deb Muth 00:39:40 Sure. GPX1 and TXN turn it into, to water. The, catalase turns it into water and oxygen. Dr. Deb Muth 00:39:58 Now, I see a lot of my clients who have mutations or SNPs on that GPX gene, on that glutathione gene. And they really struggle to clear a lot of their toxins. Bob Miller 00:40:12 Sure. Dr. Deb Muth 00:40:14 Yeah, absolutely. Well, GPX4. Bob Miller 00:40:18 is what, repairs, but you can see GPX1 Is what uses glutathione. To turn hydrogen peroxide. So, but it all depends upon having enough glutathione. Dr. Deb Muth 00:40:30 Yeah. Bob Miller 00:40:31 Well, guess who controls making a glutathione? Dr. Deb Muth 00:40:34 Nerf 2. Bob Miller 00:40:37 So, if you have a keep one weakness, or strength to two… I’m sorry, keep one is too strong. Nrf2 is too weak. You don’t make glutathione. So, when a lot of people do that, it’s like, well, I’m gonna take glutathione. Dr. Deb Muth 00:40:51 Right. Bob Miller 00:40:52 And some do great, and some do poorly. You know, because… and I’ll show this on one of the other charts. You can see here that the, The glutathione has to be recycled. And if we don’t recycle it, it actually turns into superoxide free radical. So… NADPH are the cofactors, For taking the oxidi… here’s oxidized glutathione, here’s reduced. So, this is a good glutathione. After it does its job, you can see it becomes oxidized.We need to recycle it. Well, if we have weakness on the enzyme that does that, or a weakness in Nrf2, or not enough NADPH. The oxidized glutathione never gets recycled. So, I’ve talked to a lot of people who said, oh, glutathione made me so sick, and say, well. Dr. Deb Muth 00:41:43 Yeah. Bob Miller 00:41:44 You need it, but you need to recycle it. Dr. Deb Muth 00:41:46 Can you speak for just a brief moment, too, about MTHFR? That is a very popular gene, it’s all over social media as the major gene, but can you speak to a little bit about that, and how that fits into this whole process of things? Because it is just such a small piece. Dr. Deb Muth 00:42:04 understanding genetics. Bob Miller 00:42:06 Yeah, to be honest, it drives me nuts. Dr. Deb Muth 00:42:08 Me too. Bob Miller 00:42:11 Alright, so… You know, there are people on social media I won’t say what I think, I’ll be kind. But… But the, And, you know, they might mean well. But they talk about, if you have MTHFR and COMT and PEMT, that’s… oh my goodness, that’s horrible, and we’ll fix that for you, and you’ll be fine. Bob Miller 00:42:36 it just irritates me to no end. And it really could get anybody who’s doing this legitimately in trouble. I mean, I’m afraid someday, you know, there might be some cracking down on this kind of nonsense. Now, to answer your question about MTHFR. Dr. Deb Muth 00:42:51 I mean, it really is, but I’ll tell you what, why don’t we hold that thought until I go to another map and I can actually… Okay. Bob Miller 00:42:56 But the real… the cliff notes is the MTHFR puts a methyl group on your folate, which is needed, but it has gotten way, way, way too much attention. And people learn they have MTHFR, and they start taking a multivitamin with methylfolate, then they take a B vitamin with methylfolate. Dr. Deb Muth 00:43:13 And they’re pushing it too hard. Bob Miller 00:43:15 Yeah. So I can’t tell you how many people I’ve helped by saying, stop it. Dr. Deb Muth 00:43:20 Yeah, take less of it. Bob Miller 00:43:21 Take less of it, yeah. So, yeah. Yeah, there’s a… If somebody, say, ranked the enzymes at their level of importance, MTHFR might be 40 or 50 on a scale of 100, you know. Keep one Nerf two. big deals. Dr. Deb Muth 00:43:40 deals. Bob Miller 00:43:41 NQO1 that I didn’t even talk about yet, NQO1, takes your, NA… your NAD goes into NADH, To make electrons for the electron transport chain. you need NQ01 to bring that back. If that’s not working, and I’ll show you on the NAD map how disastrous that can be. Now, the next piece is here, and I think You know, if you talk to any school teachers and say, if you’ve taught for more than 10 years, how are the kids today? Every one of them says, more ADD, ADHD, more autism. Just look at human beings, we’ve never been so agitated. You know, everybody, and it might be a social media thing, but people take a position on something, and if anybody doesn’t share that position, they view them as the enemy. Dr. Deb Muth 00:44:29 And it’s kind of scary what’s happening to us. Bob Miller 00:44:33 So, we can’t agree to disagree anymore. We see anybody who has a differing opinion as the enemy. And, you know, there was… there’s people that didn’t have Christmas dinners together, because they had political differences, like… Dr. Deb Muth 00:44:44 Excuse me. Bob Miller 00:44:45 can’t you put your political differences aside to have Christmas together, you know? Dr. Deb Muth 00:44:49 Right? Bob Miller 00:44:50 become that, you know, no matter what your position is, and I’m not saying anyone’s right or wrong, I’m just saying. You know, in the old days, they used to say that the Republicans and Democrats in Congress would argue policy and then go have dinner together. And now everybody’s all up in arms, angry. Dr. Deb Muth 00:45:05 Yeah. Bob Miller 00:45:06 So… There’s likely multiple reasons for that. But let me show you one of them. That, you know, to what degree this is… very important, we don’t know, but I think We’re beginning to believe this is very important. So, there’s something… there’s a neurotransmitter called GABA. And God buys the don’t worry, relax, be happy. Chill. Okay. Dr. Deb Muth 00:45:31 Nobody has enough of that anymore. Bob Miller 00:45:33 Well, yeah, you’ll be surprised what I’m gonna show you. So, let me see if I can find a, Let me see if I can find the right slide here. Let me look for it here. So, there’s something called a GABA receptor site. And here you can see… This is a neuron, and this is where you, The neuron normally is excitatory. However, there’s normally low chloride in the neuron. Dr. Deb Muth 00:46:09 Hmm. Bob Miller 00:46:10 So, GABA itself is neither relaxing. For excitatory, all GABA does, it opens up what’s called a chloride channel. And then chloride, which has a negative charge, will flow into the neuron. Follow me there? Dr. Deb Muth 00:46:26 Yep. Bob Miller 00:46:27 And as it does, it changes this from a positive charge to a negative charge, And it’s relaxing. and inhibitory. Dr. Deb Muth 00:46:34 Hmm. Bob Miller 00:46:36 Now, on the other hand, there’s enzymes called NKCC1, That will push chloride in. and KCC2 that will bring chlor… oops and bring chloride out. And then there’s a sodium channel. And, sodium has a positive charge. And glutamate will push that in. So, as long as this is happening. And GABA says, receptor sites, open, chloride goes in, Chill. However, If NKCC1 Pushes extra chloride in. KCC2 doesn’t pull it out. and GABA hits the receptor site, the GABA comes flowing out, Sodium comes in, And now it’s excitatory. So Gabba didn’t change. GABA just opened the receptor site, that’s all it does. Dr. Deb Muth 00:47:33 Yeah. Bob Miller 00:47:34 But it’s the chloride balance that’s going to determine whether this is relaxing or not. Now, these are the things that go along with when they lose that KCC2 or gain NKCC1. Pain and sensitivity, burning electrical, neuropathic pain. Normal touch hurts. Sound and light sensitivity. Tinnitus can flare. Headaches and migraines. Seizure tendency. Body jolts. Spasticity, cramps, stiffness, startle reflex. Trouble falling asleep, non-restorative sleep. Anxiety, stress, reactivity, that’s what we have now. Hyperarousal, panic-like surges, irritability, racing thoughts. Brain fog, slowed processing, working memory slip-ups. Mental fatigue. Episodes of racing hearts, sweaty palms, guts on edge. Those are all the things that happen when this GABA switch occurs. Now, here’s what happens, and this is what I’m going to be presenting at an autism conference. When you have a newborn, they need that NKCC dominant to develop. By early childhood, it should… or, sorry, early adulthood. we should move over to the KCC dominant, that’s the taking the chloride out. Nice-looking 25-year-old boys, functioning very well. However, when we get microglia M1 upregulated. Because of environmental toxins, processed foods, Tylenol, aluminum. they stay in NKCC1 dominant, and there’s ADD, ADHD, Autism, the whole spectrum. because… They’ve not moved over to the… They’ve not moved over to the KCC2. And again, this is caused by… Environmental factors. Stimulating the microglia. And then, interleukin-1, interleukin-18 weakens KCC2, interleukin-1 beta, Strengthens NKCC1. high chloride. We open up the chloride channel, In Rebell Excitatory. So, I think when, When the pediatricians get ahold of this, they’re going to be very excited to know that This could be why we’re seeing such a rise, and not just autism, but ADD, ADHD, anxiety, the whole shit mess. Dr. Deb Muth 00:49:58 thing. Bob Miller 00:49:59 Yeah, so… and you can see NF-kappa-B stimulates that. These stimulate it, and I think that’s why everyone’s getting so anxious. Now, there’s a little bit more to it, and we’ll get into this when we look at some of the maps, but… The, the glutamate, Which is excitatory. will stimulate the NMDA receptor, make more glutamate, And glutamate will inhibit KCC2. And then we also need an astrocyte To, take both ammonia And glutamate, and… Turn them back into glutamine. And I’m going to talk to you a little bit about arachidenic acid, and if we have too much arachidenic acid. or TNFA is upregulated, that doesn’t happen. Ammonia goes up, and there may be multiple reasons for this, but this is a reason why some of the autistic kids do flapping. Dr. Deb Muth 00:50:49 Hmm. Bob Miller 00:50:50 Because they’re not clearing their ammonia. And you can tell if somebody has high ammonia by… they get that old person smell, you know. Dr. Deb Muth 00:51:00 Yup. Bob Miller 00:51:01 your vehicle cycle’s not taking out the, the ammonia. Now, last pathway here. There’s growing interest in mast cell activation. So, back here, we talked about peroxynitride. And that will stimulate mast cells, and those are white blood cells that are your best friend, unless they’re your worst enemy. Then it’ll make histamine. And there’s enzymes called histidine decarboxylase that’ll make more. Dr. Deb Muth 00:51:28 I’m sure everybody’s heard of DAO, the enzyme that degrades histamine. Yep. Bob Miller 00:51:31 We can have genetic weakness, we don’t make that. There’s an enzyme called histamine and methyltransferase, That, That breaks down the histamine. Then if we don’t do that, it’ll get stuck in the histamine receptor site. And then it’ll make something called, renin. Which will cause angiotensinogen to turn into angiotensin. One, that turns into angiotensin II,And that’s where people make aldosterone, where they’ll get the, The swollen ankles and high blood pressure. But interestingly, there’s an enzyme called ACE2, that takes this guy and turns it into angiotensin 1-7, Which is anti-inflammatory and also inhibits… TNFA. Now, you can have weakness on ACE2, But… and anybody’s saying, that sounds familiar? Dr. Deb Muth 00:52:25 That’s where COVID comes in, using ACE2. Bob Miller 00:52:28 And now we just found there’s literature that if you get COVID long enough, it can actually make ACE2 not be able to work as well. So look what it does. It comes down here, stimulates the NADPH oxidase, More superoxide. More peroxynitrite. And we’re on a cycle here. We’ve actually named this the Home Cycle Hypothesis, the proposed feed-forward loop. That just keeps feeding on itself. All being caused by… Primarily, The environmental factors. But hitting those who have genetic weakness the hardest. That’s why. Dr. Deb Muth 00:53:08 To the people. Bob Miller 00:53:09 Don’t live in a moldy house. One person is sick as can be, and the other person says, well, you must be imagining things, because I don’t feel anything. Dr. Deb Muth Yeah. Same thing with long haul, right? Two people can both get sick, one gets sick and never seems to recover, and somebody else gets sick, and they have absolutely no problems with it at all. Bob Miller 00:53:30 Sure. Well, think about it, if you get COVID, and ACE2 is weak, and some of this other stuff is going on. This thing just starts feeding upon itself. Dr. Deb Muth 00:53:38 Keep creating more inflammation, more complications, nothing’s calming down. Bob Miller 00:53:43 Yeah. Now, you, you ask about, MTHFR. So, this is the, this is the, the software called Functional Genomic Analysis. There’s a demo report we have. So, let’s talk a little bit about, MTHFR. So, we actually have a map called a methylation map. Now, what happens is, when you do your saliva test, you, you know, you spit, you put some saliva. in a collection kit, goes to a lab, takes out the DNA data, sends it to the computer, and now you can actually see it visually. Okay. So, it’s gonna take a second for this, data to load up, it’s, and each of these Circles, each of these ovals, is an enzyme. And the data gets loaded up to see where it is. So, until it gets loaded up here, I didn’t preload this. There it goes. So… The primary thing about methylation is There’s a nasty substance called homocysteine that, if it’s too high, can really be detrimental. The body takes methylfolate, and combines with methyl B12, To bring this back up to methionine. And then through the MAT genes, we make SAMI, S-adml methionine. Which is involved in so many processes. Then after it does its thing, it turns back into homocysteine. And this thing needs to keep spinning around. That’s why, you know, it’s a good idea to keep homocysteine at, do you have a number that you’d like? 7, 8? What do you like for a number? Dr. Deb Muth 00:55:24 Yeah, I like mine below 7. Bob Miller 00:55:26 Yeah. So if the homocysteine goes too high. It, caused all kinds of problems. So, here’s where you ask about the MTHFR. So, here you can see on this individual. I click on MTHFR, and you can see it comes up here, here’s the C677. And you can see here where it says, variants. I’ll… I’ll draw in case somebody’s having a hard time seeing that. So, you can see there’s nothing in there. That means there’s no genetic mutations. If one parent would have given a mutation, there’d be a 1. If both parents did, there’d be a 2. Now, here’s why Yes, methylation is important, I’m not saying it isn’t important, but look at this MTHFRC677. In my software. Only 42.5% of the population does not have a mutation. 44.7% have won. 12.9 have 2. So, this isn’t some rare, oh my god, I’m gonna die… Kind of thing, yeah. Dr. Deb Muth 00:56:27 Right. Bob Miller 00:56:28 So, And then what happens is that, and again, I’m not dismissing methylation, I… we could do a whole show on methylation. Bob Miller 00:56:36 get it. But I think that what people are doing is they’re, they’re learning about MTHFR, they get it measured, they panic. They start taking massive amounts of methylfolate, which many times is to their detriment. Dr. Deb Muth 00:56:50 Well, it’s… and isn’t it true, too, with MTHFR, like, you have to also look at MTR, MTRR, and the more we stack up of those, the more complicated than MTHFR can be. It’s not… it’s not as simple as just saying MTHFR 677 versus 1298. It’s more complex than that, kind of like what you’ve already shown with some of the other things. There’s more to it than just that one little sliver. Bob Miller 00:57:17 Oh, sure, well, let’s take a look. So, remember I said there’s a cofactor? One of the cofactors is called FAD. Just a Bob Miller observation, that’s all. But when people have trouble with their riboflavin and they don’t have enough FAD, They’re doing much worse than people who have just a C677. So, right here, you could have perfect C677th. And if you don’t have the cofactor, it’s not gonna work, okay? Dr. Deb Muth 00:57:48 And as you said, there’s an MTR enzyme. Bob Miller 00:57:51 that takes methylfolate and methyl B12, to spin it around. So, here on this individual. here’s your… here’s your B vitamins, or I’m sorry, your B12s. There’s an enzyme called TCN1 that takes it from the stomach into the blood. Then there’s other enzymes that take it from the blood into the tissue. And if you’re having trouble here. Well, then you’re not going to have this working, so… Even if you don’t have MTHFR, And you have MTR, like this, no, I’m sorry, this person doesn’t. But they have the MTRR, and then they don’t have enough B12, this isn’t gonna work, aside from that. And then there’s a middle pathway. And then there’s enzymes called the MAT1. they take the methionine to the salmon. If that’s not working, we stick… we get stuck in methionine. So, it’s, it’s not just an MTHFR. And then, one of the things that people forget about. is through these CBS enzymes and CTH, We make cysteine, which is needed to make glutathione. The master antioxidant. So, it really is that… I call it the, The 3D chess game played underwater. Dr. Deb Muth 00:59:07 It really is. I mean, I see people who have CVS, COMT, glutathione, MGHFR genes. And some of them function just fine. Like, they have Like, I look at this person and I’m like, oh my gosh, I don’t know how they’re functioning because they’re double mutated on so many pathways, but yet they don’t have a lot of symptoms, they don’t have a lot of complications. Somehow their body has figured out a way to adapt to what it has so it can stay alive and it can function at a high functioning level. Bob Miller 00:59:36 Yeah, and they may be, you know, eating right? Yeah. Staying out of a moldy house. reducing stress. So, it’s diet, it’s stress, it’s genetics, environmental factors. So, yeah, we can’t just say somebody’s gonna be good or somebody’s gonna be bad. You know, some people get scared, oh, I got all these, it’s like, well… Bob Miller 00:59:56 Are you living in a moldy house? You know, and if you live in a moldy house and your glucuronidation pathway doesn’t do well, or if you’re, you know, a smoker, or you’re constantly eating junk food, I mean, all. Bob Miller 01:00:07 things come together. Although, you know, when we focus on genetics, we’re well aware that this is just a piece of it. You know, you could have identical twins, Genetically, and if one… Is exposed to mold and smokes and drinks and stressed out. They’re gonna be a whole lot sicker than their sibling. Bob Miller 01:00:28 Yep. Dr. Deb Muth 01:00:29 Yeah, it’s that concept of taking twins, and one gets raced with one family, and one gets raced with another family, and they don’t have the same… problems that… that each other have, you know? It’s a very unique situation, we don’t think about that enough. Bob Miller 01:00:44 Alright, so again, genetics loads the gun, environment pulls the trigger. So, if you’ve got a loaded gun, but you don’t have the triggers, you’re okay. Dr. Deb Muth 01:00:53 Yeah. Bob Miller 01:00:54 Yeah. So, remember I said I was going to talk about NAD? So, here’s NAD, and what it does, it turns into NADH. And what NADH does, it, Comes down this pathway, what’s called the electron transport chain. And that makes your ATP, that’s your energy. So, if this wasn’t working, we wouldn’t be alive, because we wouldn’t have energy. So it donates an electron, that’s why it’s called electron transport chain. So, we need NAD, To make this, to make the energy. But remember I said that NQ01, this would probably be, like, on my top 10 list of… Bob Miller 01:01:36 Much more important than MTHFR. This one takes NADH back to NAD. If we’re stuck over here, We’re low in this NAD+, But what happens is, NQO1 also provides CoQ10. And CoQ10 Is what’s needed for the electron transport chain to flow. So if we get too many electrons up here. And they don’t turn them into energy. They make a nasty free radical called superoxide. Okay. Now, NAD plus also makes NADPH, And that is needed. Remember I said we need to recycle our antioxidants. So, if we have a problem with FAD from riboflavin. Yeah, we don’t have enough NADPH, Glutathione’s not getting recycled, and you’re gonna be inflamed. And you take glutathione, you’ll feel worse. There’s another enzyme called thimoredoxin. Same thing, needs NADPH and FAD. And same way with your nitric oxide, there’s an enzyme called NOS3, That makes the nitric oxide that dilates your blood vessels. And if we don’t have enough NADPH or fat, You’re gonna make superoxide. Rather than nitric oxide. Now, remember

Jordan's back from Soccer Aid with tales from the dressing rooms. Not to be outdone on dressing room chat, William's been hard at work preparing for his West End debut and has an update on his bevel. The boys also help you with your dilemmas involving changing hairdressers, massage parlour faux pas, and how to confront your partner over his secret stash of Viagra.If you want to get involved you can email us, and for more Sexted fun sign up to our free VIG&Diva newsletter. You can follow us and DM on Instagram and TikTok, and watch the latest episode every Tuesday and Friday on YouTube.Help I Sexted My Boss is presented by William Hanson and Jordan North. It is an Audio Always production. Hosted on Acast. See acast.com/privacy for more information.

ham sliced so thin you could read a newspaper through it

Max Verstappen is vliegensvlug thuis, talloze straffen in de pitstraat, een onnavolgbare Kimi Antonelli en woede bij George Russell. Vanuit The Harbour Club in Vinkeveen:•⁠ ⁠Presentator Frank Evenblij•⁠ ⁠F1-commentator Olav Mol•⁠ ⁠⁠Radio DJ Rob van Someren•⁠ ⁠⁠Nederlands meest controversiële F1-analist Ronald Molendijk Disclaimer: Alle gebruik van hetgeen in deze podcast ‘F1 aan Tafel’ wordt opgemerkt is ongeoorloofd zonder expliciete schriftelijke toestemming ter zake verkregen van Grand Prix Radio en met inachtneming van een duidelijke bronvermelding met link.See omnystudio.com/listener for privacy information.

This is Part 1 of a five-part miniseries on Tim Griesheimer's life. Tim is by far one of the most popular guests we've had on the show, so this series dives even deeper into his life featuring new stories about gang life, prison, identity, trauma, and redemption. In this episode, Tim shares the early chapters of his life, from growing up in an abusive household to finding acceptance in the streets, gang culture, and eventually prison. Tim opens up about what it was like being white while running with mostly Black friends and Blood gang members, how racial dynamics differed between Ohio and Texas, and the controversy around using the n-word. He also describes childhood violence, early crime, carrying guns as a kid, shootouts, and how he became drawn to the outlaw lifestyle before his first prison sentence. Topics include: -Growing up in Ohio and Texas -Childhood abuse and street life -Being white around Blood gang members -Saying the n-word and facing consequences -Early gun violence and shootouts -Racial tension in Texas -First experiences with prison politics -Finding identity through crime and gang culture Go Support Tim! IG: https://www.instagram.com/tattoos_bykriminalkustoms/ This Episode Is #Sponsored By The Following: Hims! To get simple, online access to personalized, affordable care for ED, Hair Loss, Weight Loss, and more, visit https://hims.com/connect Prescription required. See website for details and important safety information. Sildenafil is the generic version of Viagra®. Viagra® is a registered trademark of Viatris Specialty LLC. Hims is not affiliated with or endorsed by Viatris. Join The Patreon For Bonus Content! https://www.patreon.com/theconnectshow 00:00 From a Troubled Home to the Streets 01:01 Introducing Tim Griesheimer's Story 04:47 Connecting with People and Early Social Traits 07:09 Nature vs. Nurture and Developing an Outlaw Mentality 10:27 Embracing the Streets: Stealing and Early Crimes 13:01 Fighting, Survival, and Street Cred 17:08 Shootouts and Guns at a Young Age 21:12 Gang Affiliations: Bloods, Crips, and Neighborhood Politics 25:48 This Episode Is Sponsored By Hims 27:38 Reflecting on Gang Life, Family Bonds, and Military Ambitions 33:13 Childhood Abuse and Family Trauma 36:50 Violence at Home and Resentment Toward Parents 41:13 Cycles of Abuse: Family History 43:14 Moving Between States & Unstable Upbringing 45:27 Culture Shock: Racial Dynamics in Texas vs. Ohio 48:00 Experiencing Prejudice from Both Black and White Communities 50:01 First Time Going to Prison – Facing Reality 54:01 Arrival at the Most Dangerous Texas Prison 56:11 Navigating Prison Politics and Racial Pressure Learn more about your ad choices. Visit podcastchoices.com/adchoices

I tillegg til Viagra-spons - Debatten om blomstrede kjoler - Terapi fra Viken Fiber Episoden kan inneholde målrettet reklame, basert på din IP-adresse, enhet og posisjon. Se smartpod.no/personvern for informasjon og dine valg om deling av data.

For decades, men had Viagra. Women were told to relax and have a glass of wine. That imbalance in pharmaceutical innovation is finally changing, but it hasn't been easy.In this episode, I talk with Sabrina Johnson, the founder and CEO of Dare Bioscience the only publicly traded pharmaceutical company focused entirely on women's healthcare. We discuss why the pharmaceutical industry has historically avoided investing in women's sexual health, the stigma and sexism that surrounds female arousal and pleasure, and what it actually takes to develop and bring products to market.Sabrina walks us through the development of Dare to Play, a topical cream for sexual arousal that's coming soon, the science behind how it works, and the extensive clinical trials required to prove safety and efficacy. We also discuss other products in development a probiotic for vaginal health and a once-a-month vaginal ring for menopause with estradiol and progesterone. This is about changing what's possible for women's health.From regulatory hurdles to cultural stigma, the barriers to innovating in women's sexual health are real. In this conversation, we explore how companies can create real world solutions that actually work for women's lives, the importance of rigorous clinical testing, and why investing in women's health matters. We dive into the science, the business side, and how you can support this work.Highlights:Only 1% of private investment in pharmaceutical development goes to companies innovating solely for women which is why there's so little funding and so many gaps.The stigma is real: one NPR station refused to air an interview because Sabrina said the word "vagina" too many times.Dare to Play increases blood flow to genital tissue for sensation and lubrication the same mechanism as Viagra, but in cream form. The major innovation was developing specialized delivery technology to get sildenafil through skin and manufacturing at pharmaceutical grade standards rather than compounding standards.Dare worked with the SEC and NASDAQ to create a direct public offering so anyone can invest with just $250, not just institutional investors.I hope this episode inspires you to think differently about women's health innovation and what's possible when we demand better. If you believe in the work DARE is doing, you can support it. You don't have to donate you can become an investor with as little as $250. All the information on how to do that will be below.Get in touch with Sabrina:WebsiteBecome an InvestorInstagramLinkedInTikTokGet in Touch with Me:WebsiteInstagramYoutubeSubstack

its not a joke anymore. im on the roof and its not funny anymore. im green. Hims connects you with licensed healthcare providers online, giving you simple access to legitimate ED options from home. No awkward appointments, no pharmacy lines.Just complete a simple online intake, and a provider will review your information to determine if treatment is right for you. If prescribed, your treatment ships directly to your door in discreet packaging.That includes Sildenafil, also known as Generic for Viagra®, available through Hims at up to 95% less than the brand-name version. And if that option isn't right for you, there are additional treatment options available—so you can find what works best for your body.Get HimsSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

On this week's episode, Will helps Scotty with the sound board, and JP does not like it. Is Derek's absence overrated or underrated, and what are some taglines for Viagra. where is the weirdest place you have done the dirty and could you have s dead battery smoke doctor in your house? Enjoy another episode and keep on laughing.

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Former federal inmate Eric King joins to expose what life is really like inside ADX Florence, America's most notorious supermax prison. After being sentenced to 10 years for firebombing a politician's office in 2014, King says he endured brutal treatment in federal custody, including beatings, starvation, solitary confinement, four-point restraints, and years of communication restrictions. In this episode, Eric opens up about his radicalization in Kansas City, the Ferguson protests, his federal case, surviving violent prison politics, fighting a guard in self-defense, winning at trial, and later being sent to ADX Florence in what he believes was retaliation. He also explains the psychological toll of extreme isolation, the myths surrounding ADX, how prisoners communicate inside, and what it took to rebuild his life after release. Eric is the author of A Clean Hell: Anarchy and Abolition Inside America's Most Notorious Dungeon, a firsthand account of survival, resistance, and humanity inside the federal prison system. Topics include: -Eric King's childhood and political awakening -Ferguson, direct action, and his federal charges -Violence, solitary confinement, and prison retaliation -Life inside ADX Florence -The psychological effects of extreme isolation -Reentry, trauma, family, and healing after prison Go Support Eric! Book: https://pmpress.org/index.php?l=product_detail&p=1872 IG: https://www.instagram.com/supportericking/ This Episode Is #Sponsored By The Following: Hims! To get simple, online access to personalized, affordable care for ED, Hair Loss, Weight Loss, and more, visit https://hims.com/connect Prescription required. See website for details and important safety information. Sildenafil is the generic version of Viagra®. Viagra® is a registered trademark of Viatris Specialty LLC. Hims is not affiliated with or endorsed by Viatris. Cash App! Download Cash App Today: https://capl.onelink.me/vFut/1ekoiacn #CashAppPod. Cash App is a financial services platform, not a bank. Banking services provided by Cash App's bank partner(s). Prepaid debit cards issued by Sutton Bank, Member FDIC. See terms and conditions at https://cash.app/legal/us/en-us/card-agreement. Cash App Green, overdraft coverage, borrow, cash back offers and promotions provided by Cash App, a Block, Inc. brand. Visit http://cash.app/legal/podcast for full disclosures. Join The Patreon For Bonus Content! https://www.patreon.com/theconnectshow 00:00 Eric King Introduction 02:00 Eric's Early Life & Radicalization 06:00 Growing Up: Crime, Poverty, and Activism 12:00 Losing Faith & Early Legal Troubles 18:00 Protest, Ferguson, and Political Activism 21:06 This Episode Is Sponsored By Hims 22:41 The Crime: Ferguson Response & Arrest 29:00 Prison: First Experiences & Racial Politics 34:00 Surviving Prison Culture & Targeting 40:00 Abuse by Guards & Florence Medium Incident 45:42 This Episode Is Sponsored By Cash App 47:00 Torture, Four-Point Room & Transfer Hell 53:00 Isolation, Violence, and Solitary Life 01:00:00 Fighting Back: Resistance & Prison Protests 01:14:00 Second Trial: Self-Defense, Winning in Court 01:20:00 ADX Florence: Punishment & Reprisal Transfers 01:28:00 Arriving at ADX: Conditions and Isolation 01:37:00 ADX Daily Life & Psychological Impact 01:49:00 Punitive System, Corruption, and Quota Reality 01:56:00 Surviving Isolation: Mental Discipline & Gratitude 02:00:00 Reentry: Life After Prison & Its Challenges 02:06:00 Reflection: Regrets, Growth, and Activism Now 02:12:00 ADX Realities, Mythbusting & Book Release 02:18:00 ADX Procedures, High-Profile Inmates & Closing Learn more about your ad choices. Visit podcastchoices.com/adchoices

If Part 1 was about the field of sexual medicine, Part 2 is about the marriage at the center of it. Dr. Jenni Skyler and Daniel Lebowitz return to their conversation with Dr. Irwin and Sue Goldstein, and this time, the questions get more personal. How do you stay married for fifty years? What does great sex actually look like across the decades? And what happens when a woman who has spent her career in sexual medicine starts experiencing low desire herself? Sue Goldstein opens up about her own journey through peri-menopause and the slow erosion of her libido- what she calls "duty sex", and the medications that brought not just her sex drive back, but a playfulness in her marriage she hadn't realized had gone missing. She walks listeners through her menopause toolbox of five treatments, explains why she's "76 and feels like she's in her 50s", and dismantles the lingering fears from the Women's Health Initiative that have kept generations of women in what she calls hormone prison. Dr. Irwin shares his own daily protocols for sexual health, why he believes most older men are leaving capacity on the table, and the surprising data from their own clinic- that more than half the Vyleesi prescriptions they write are off-label for men. They explore why dopamine is dopamine, regardless of gender. The reality of persistent genital arousal disorder. And a remarkable story of a teenage horseback rider whose chronic arousal turned out to be a herniated disc. This episode is full of practical wisdom, clinical innovation, and one of the most real conversations about long-term love you'll hear all year. The Goldsteins' secret to fifty years of marriage? Best friends, good sex, and the willingness to keep trying new things — including a chocolate sauce on the day before you change the sheets. Irwin Goldstein, MD, IF (he/him/his). Director, San Diego Sexual Medicine 5555 Reservoir Drive, Suite 300, San Diego, CA 92120, Director, Sexual Medicine, UC San Diego Health East Campus, San Diego, CA. Clinical Professor of Urology, University of California at San Diego. Voluntary Clinical Professor of Obstetrics, Gynecology and Reproductive Services Past President, International Society for the Study of Women’s Sexual Health. Past President, Sexual Medicine Society of North America. Editor Emeritus, Sexual Medicine Reviews, The Journal of Sexual Medicine, International Journal of Impotence Research. Phone: 619 265-8865 - Mobile: 619 987-7432. Email: dr.irwingoldstein@gmail.com. http://www.sandiegosexualmedicine.com. Like us on Facebook: https://www.facebook.com/SDSexMed. X: http://twitter.com/SDSexualMedSee omnystudio.com/listener for privacy information.

How did Ozempic, Prozac, & Viagra get their names?... It's the wild world of drug-naming.Now is the perfect time to ask your landlord to cut your rent… We got the receipts & playbook.Google's Search Bar is history's most profitable feature… But last week it got plastic surgery.Plus, the hot new vacation trend is lights-off… Dark Sky Vacations have never been brighter.$GOOG $NVO $MARNEWSLETTER:https://tboypod.com/newsletter OUR 2ND SHOW:Want more business storytelling from us? Check our weekly deepdive show, The Best Idea Yet: The untold origin story of the products you're obsessed with. Listen for free to The Best Idea Yet: https://wondery.com/links/the-best-idea-yet/NEW LISTENERSFill out our 2 minute survey: https://qualtricsxm88y5r986q.qualtrics.com/jfe/form/SV_dp1FDYiJgt6lHy6GET ON THE POD: Submit a shoutout or fact: https://tboypod.com/shoutouts SOCIALS:Instagram: https://www.instagram.com/tboypod TikTok: https://www.tiktok.com/@tboypodYouTube: https://www.youtube.com/@tboypod Linkedin (Nick): https://www.linkedin.com/in/nicolas-martell/Linkedin (Jack): https://www.linkedin.com/in/jack-crivici-kramer/Anything else: https://tboypod.com/ About Us: The daily pop-biz news show making today's top stories your business. Formerly known as Robinhood Snacks, The Best One Yet is hosted by Jack Crivici-Kramer & Nick Martell. Hosted on Acast. See acast.com/privacy for more information.

Did JLR get his car repairs done? Why do public bathroom toilet seats have a gap in the front? In a new Netflix docuseries Michael Jackson's child molestation Trial is going to be revisited. Rover enjoyed using his bidet at bankruptcy box. Has JLR taken his Viagra?See omnystudio.com/listener for privacy information.

B2 has her 1 week follow up. Weiner mobile race. Duji had to buy a new water pump. Charlie's friend saw something shocking in the parking garage. A Tennis pro begs for an emergency bathroom break mid-math during the French Open. A woman was killed by an umbrella while eating at a restaurant. Duji needs to get a car for Gia in the next two weeks. Ferrari just released a new electric car. Did JLR get his car repairs done? Why do public bathroom toilet seats have a gap in the front? In a new Netflix docuseries Michael Jackson's child molestation Trial is going to be revisited. Rover enjoyed using his bidet at bankruptcy box. Has JLR taken his Viagra? During a college woman's softball game on ESPN, Texas vs. Arizona State, a wild comment was heard during the broadcast. Woman who is paragliding is struck by a plane. A woman in Florida passed away after she was attacked by two pitbulls.See omnystudio.com/listener for privacy information.

Text- und textilsicher: Zu Roland Kaiser eskalieren bei der Schlagernacktparty. Der verflixte Diäten-Mechanismus. Krebs für Rotwein? Herzlich willkommen zur Wochenschau mit Suse und Hajo Schumacher und diesen Themen: Niedlich: Erdogan und Putin: Autokraten eskalieren an Pfingsten. Fröhlich, optimistisch, leicht - ein Kanu-Wochenende wie Deutschland. Mit Prospekten gegen Nazis. Das schäumende Zwergflußpferdmädchen. Kriegt die SPD jetzt eine Brandmauerdebatte? Shoutout an Lissy und Kalle: Dankgottesdienst unterm Basketballkorb. Israels loose canon Ben-Gvir. Wann platzt Timmy? Zelten für die Freundschaft. Pestizide im Bordeaux: Krebs für Rotwein? Die Kriegerin und die Männer. Enhanced Games: "Nimm lieber Viagra, Schatz." Paddeln: der ultimative Beziehungstest. Vorgestellt: Die Ochsenzungensandbiene. Plus: Neuer Läuferkrimi von Michael Meisheit und Hajo erscheint. Staffel 2, Folge 42.Shownotes:Am 2.6.2026 stellen Hajo und Michael stellen den neuen Achilles-Krimi vorHier den kostenlosen MutMach-Newsletter abonnierenDie MutMacher auf steady unterstützenHier gehts direkt zu Suses Workshops Der MutMachPodCast auf InstagramPodcast Elefantenrunde mit Frank Stauss und HajoPauls Band Udo Butter und das Team mit allen AuftrittsterminenBücher:Suse SchumacherDie Psychologie des Waldes, Kailash Verlag, 2024Michael Meisheit + Hajo SchumacherLaufende Ermittlungen - großartige Krimi-Reihe mit dem Berliner Kommissar Peer Pedes.Band 1, 2 und 3 erscheinen bei Droemer Knaur. Band 3 in wenigen Wochen.Kostenlose Meditationen für mehr Freundlichkeit (Metta) und Gelassenheit (Reise zum guten Ort) unter suseschumacher.deWir bedanken uns bei Markus C. Hurek für das tolle Coverfoto. Hosted on Acast. See acast.com/privacy for more information.

The response to our first episode on penis performance problems was so big that we knew we had to come back for round two. In this episode, we're getting into the practical stuff: what to do in the moment when things aren't going as planned, how to keep your sex life feeling connected and fun even when performance issues are in the mix, and how both partners can show up for each other without making everything weird.

Patrick Bet-David and Dr Paul Saladino walk through the timeline of modern “quick fix” breakthroughs, from the birth control pill and breast implants to Viagra, GLP‑1 weight loss drugs and the explosion of Botox. Saladino argues the real frontier now is peptides, including GLP‑1s and growth‑related compounds, which can deliver dramatic short term changes but come with poorly understood long term tradeoffs for hormones, muscle, fertility and aging.

If you were at university or school with Jane and Fi, come forth! We want to hear all about it.Jane's sourced her emergency shorts, which can only mean one thing: there's a heatwave coming. Jane and Fi chat God's plan, the miracle of Peckham, sturdy bras, the side effects of Viagra, troublesome house rabbits, and splashback tiles. Plus, former alt-right political commentator and YouTuber Lauren Southern discusses abandoning the manosphere and the dangers of the internet. Lauren's memoir is called 'This Is Not Real Life'. Jane and Fi are signing off for a long bank holiday of Tummy Time. They'll reconvene on Tuesday. Our next book club pick will be a collection of short stories! 'Interpreter of Maladies' is by Jhumpa Lahiri. You can check out our YouTube channel here: https://www.youtube.com/@OffAirWithJaneAndFOur new playlist 'Coiled Spring' is up and running: https://open.spotify.com/playlist/4tmoCpbp42ae7R1UY8ofzaOur most asked about book is called 'The Later Years' by Peter Thornton.If you want to contact the show to ask a question and get involved in the conversation then please email us: janeandfi@times.radioFollow us on Instagram! @janeandfiPodcast Producer: Eve SalusburyExecutive Producer: Rosie Cutler Hosted on Acast. See acast.com/privacy for more information.

La différence entre des marrons et du viagra, un sondage qui mesure l'attractivité sexuelle de DSK et deux soldats qui tentent d'assassiner Adolf Hitler... Écoutez dans ce podcast 3 des meilleures blagues racontées par les Grosses Têtes de Laurent Ruquier. Tous les jours, en podcast, retrouvez une compilation des meilleures blagues de vos Grosses Têtes préférées.Hébergé par Audiomeans. Visitez audiomeans.fr/politique-de-confidentialite pour plus d'informations.

In this episode, Dr. Rena Malik sits down with Dr. Irwin Goldstein to explore the complex effects of commonly prescribed medications—like SSRIs and finasteride—on sexual function. They break down the science behind persistent sexual side effects, new diagnostic ultrasound techniques, and the challenges patients face in navigating these risks. Listeners gain crucial insights into medication-induced sexual dysfunction and the importance of thoughtful, informed healthcare decisions. Become a Member to Receive Exclusive Content: renamalik.supercast.com Schedule an appointment with me: https://www.renamalikmd.com/appointments ▶️Chapters: 00:00 SSRIs and sexual dysfunction00:23: Irreversible neuronal changes01:13: Risks vs. benefits of SSRIs02:23: PSSD timing and presentation05:12: 5-alpha reductase inhibitors06:13: PFS and comparison to PSSD09:01: Penile fibrosis and ultrasound12:42: Erection hardness scale14:11: Viagra study and publication18:06: Sexual medicine gaps in gynecology Let's Connect!: WEBSITE: http://www.renamalikmd.com YOUTUBE: https://www.youtube.com/@RenaMalikMD INSTAGRAM: http://www.instagram.com/RenaMalikMD TWITTER: http://twitter.com/RenaMalikMD FACEBOOK: https://www.facebook.com/RenaMalikMD/ LINKEDIN: https://www.linkedin.com/in/renadmalik PINTEREST: https://www.pinterest.com/renamalikmd/ TIKTOK: https://www.tiktok.com/RenaMalikMD ------------------------------------------------------ DISCLAIMER: This podcast is purely educational and does not constitute medical advice. The content of this podcast is my personal opinion, and not that of my employer(s). Use of this information is at your own risk. Rena Malik, M.D. will not assume any liability for any direct or indirect losses or damages that may result from the use of information contained in this podcast including but not limited to economic loss, injury, illness or death. Learn more about your ad choices. Visit megaphone.fm/adchoices

Dr. Irwin Goldstein didn't set out to become a pioneer of sexual medicine. He was a biomedical engineer turned urology resident who, as he tells it, asked one stupid question during a 1976 surgery: "Could you explain the physiology of erection to me?" The surgeon shrugged. Irwin spent the next decade figuring it out. Along the way, he co-discovered that nitric oxide, the elephant of our air, is what makes erections possible. He published the first paper on it in 1991. Seven years later, he became the first author on the New England Journal of Medicine paper that introduced Viagra to the world. But that's only half the story. The other half is Sue Goldstein, Irwin's college sweetheart turned partner in life, parenting, and eventually the practice itself. Sue spent decades raising their family while quietly absorbing the science her husband brought home. She is now an AASECT-certified educator, a published researcher, and one of the most outspoken patient advocates in the field. Together, they run San Diego Sexual Medicine, a clinic where every patient gets a three-hour visit, full education, and an entire team practicing what they call true bio-psycho social care. In this first half of our two-part conversation, Dr. Jenni Skyler and Daniel Lebowitz sit with the Goldsteins and explore how a field gets built, and how it still leaves so many patients behind. They cover prostate cancer and the silent erectile crisis that follows it. The buccal grafting innovation that's helping women with severe vestibular pain finally get answers. Why women, on average, see ten or twelve doctors before they get a real diagnosis. And Sue's pet peeve, medical gaslighting and what to do when a doctor says "there's nothing that can be done." This is a conversation for anyone who has ever felt unheard by a clinician, dismissed by their own body, or convinced they were the problem. The Goldsteins want you to know — you're not. You just haven't been to the right office yet. Irwin Goldstein, MD, IF (he/him/his)Director, San Diego Sexual Medicine5555 Reservoir Drive, Suite 300, San Diego, CA 92120Director, Sexual Medicine, UC San Diego Health East Campus, San Diego, CAClinical Professor of Urology, University of California at San DiegoVoluntary Clinical Professor of Obstetrics, Gynecology and Reproductive ServicesPast President, International Society for the Study of Women’s Sexual HealthPast President, Sexual Medicine Society of North AmericaEditor Emeritus, Sexual Medicine Reviews, The Journal of Sexual Medicine, International Journal of Impotence Researchphone: 619 265-8865fax: 619 265-7696mobile: 619 987-7432dr.irwingoldstein@gmail.comhttp://www.sandiegosexualmedicine.comLike us on Facebook: https://www.facebook.com/SDSexMedtwitter.com/SDSexualMedSee omnystudio.com/listener for privacy information.

TISS is a weekly podcast where Varun, Kautuk & Aadar discuss crazy "facts" they find on the internet. Come learn with them... or something like that.This week, the boys are talking about 'Unbelievable Origin Stories'To support TISS, check out our Instamojo: www.instamojo.com/@TISSOPFollow #TISS Shorts where we put out videos: https://bit.ly/3tUdLTCYou can also check out the podcast on Apple podcast, Spotify and Google podcast!https://shorturl.at/hfQZXhttp://apple.co/3neTO62http://spoti.fi/3blYG79http://bit.ly/3oh0BxkCheck out the TISS Sub-Reddit: https://bit.ly/2IEi0QsCheck out the TISS Discord: / discord  Buy Varun Thakur's 420 Merch - http://bit.ly/2oDkhRVSubscribe To Our YT Channels:Varun - https://bit.ly/2HgGwqcAadar - https://bit.ly/37m49J2Kautuk - https://bit.ly/3jcpKGaNeville - https://bit.ly/2HfYlWyFollow Us on Instagram:Varun -   / varunthakur  Aadar -   / theaadarguy  Kautak -  / cowtuk  Neville -  / nevilleshahChapters:00:00 Kautuk's Ligament Tear 01:02 Dedicated “Segue-jeet” Ray 01:33 The Tear Story 06:32 Intro 07:03 Origin of Potholes 09:26 Bollywood Postmortem Tour 09:59 Lie Detector Inventor 12:34 Why Chainsaws Were Invented 15:32 Smoke Alarm Invention 16:40 Wireless Baby Stroller 21:13 Teddy Bear Origins 23:28 From Canvas to Jeans 27:34 Velcro Innovation 28:29 Vaseline Origins 29:10 Creating Braille 30:18 Padman & Pads 31:08 Mario & Mustaches 31:57 Accidental Inventions 33:37 Invention of Sandwiches 35:15 Weird Ketchup Inventions 38:25 Milind Soman's Swim Expedition 40:01 Microwave Discovery 44:15 Invention of AC 45:08 Printing Press Origins 48:13 Pringles Can Design 50:50 Potato Chips by Spite 51:44 €3 Award-Winning Wine 53:51 Hitachi's Accidental Blunder 56:04 Frisbee Origins 57:12 Viagra's Real Purpose 58:02 Evolution of Botox 01:00:17 Discovery of Boba 01:02:10 Origins of Famous Phrases 01:03:18 Sandal Soap Origins 01:04:21 Origin of Shampoo 01:04:40 “Buttering” Someone 01:05:02 “Cat Got Your Tongue?” 01:05:18 Parle-G During War 01:06:08 “The Whole 9 Yards” 01:06:57 Creation of Thums Up 01:08:16 Creation of Fanta 01:08:49 Why Hulk Is Green 01:09:54 Art & Technology 01:10:30 Evolution of Art 01:12:24 Evolution of Art (Contd.) 01:13:52 Why Flaws Are Memorable 01:15:37 Google's Big Mistake 01:16:07 Movie Color Differences 01:17:29 The Old Monk Phenomenon 01:19:14 Just Water 01:20:46 Engage & Comment Please 01:21:42 OutroEdit & Thumbnail - MetaFX Studio

Our guests this week are two accomplished sexuality professionals – Ms. Sue Goldstein and Dr. Irwin Goldstein. Ms. Sue Goldstein, a graduate of Brown University, is Sexuality Educator and Clinical Research Manager at San Diego Sexual Medicine (SDSM), responsible for sexual medicine educational programming and clinical research. She works with the SDSM team to develop clinical research projects, write protocols and oversee clinical trials. Ms. Goldstein co-authored When Sex Isn't Good to provide education and empowerment to women with sexual dysfunction. She is an associate editor of Textbook of Female Sexual Function and Dysfunction, and Female Sexual Pain Disorders, and author of multiple peer reviewed papers. Ms. Goldstein is past president of the International Society for the Study of Women's Sexual Health (ISSWSH). She served on committees in the International Society for Sexual Medicine (ISSM) and Sexual Medicine Society of North America (SMSNA). She is also a member of the American Association of Sex Educators, Counselors and Therapists (AASECT), the Association of Clinical Research Professionals (ACRP) and the International Society for Medical Shockwave Therapy. Ms. Goldstein, an ISSWSH Fellow, received the Distinguished Service Award from ISSWSH in 2017 as well as from SMSNA in 2017, and along with her husband, the Transformatory Team Award from ISSM in 2024. Dr. Irwin Goldstein has been involved with sexual dysfunction research since the late 1970s. He has authored more than 380 publications as well as multiple book chapters and edited 7 textbooks in the field. His interests include surgery for dyspareunia, sexual health management post cancer treatment, persistent genital arousal disorder/genital dysesthesia, physiologic investigation of sexual function, and diagnosis and treatment of sexual dysfunction in all genders. Dr. Goldstein is Director of Sexual Medicine at University of California San Diego East Campus, and sees patients in his private practice, San Diego Sexual Medicine. He is a Clinical Professor of Urology and Voluntary Clinical Professor of Obstetrics, Gynecology, & Reproductive Sciences at University of California San Diego. He is past Editor-in-Chief of the International Journal of Impotence Research, The Journal of Sexual Medicine, and Sexual Medicine Reviews. He is Past President of the International Society for the Study of Women's Sexual Health (ISSWSH) and the Sexual Medicine Society of North America (SMSNA). He holds a degree in engineering from Brown University and received his medical degree from McGill University. The World Association for Sexual Health awarded the Gold Medal to Dr. Goldstein in 2009 in recognition of his lifelong contributions to the field, in 2012 he received the ISSWSH Award for Distinguished Service in Women's Sexual Health, in 2013 he received the Lifetime Achievement Award from the SMSNA, and in 2014 he received the Lifetime Achievement Award from the International Society for Sexual Medicine (ISSM). He is happily married to his college sweetheart Sue, and together they have three children and five grandchildren. Sue and Irwin Goldstein have been titans in the field of sexology for some time now; they were there on May 14, 1998 when the first article on sildenafil (Viagra) was published with Irwin Goldstein as the first author. Listeners, if you would like to reach out to Ms. Sue Goldstein and/or Dr. Irwin Goldstein, check out the San Diego Sexual Medicine website! If you want to catch up on other shows, just visit our website and please subscribe! We love our listeners and welcome your feedback, so if you love Our Better Half, please give us a 5-star rating and follow us on Facebook and Instagram. It really helps support our show! As always, thanks for listening!  

Charlie is a shade of pink. Rover says he will walk his marathon in 45 days or less. The AC is broken back at home. Putting condiments in the fridge. The Pee Poo Poo Man. Krystle's daughter is graduating. B2 is having surgery today. JLR has not yet taken his Viagra. Charlie takes his Klonopin before going to the dentist. Calling 911 because there is a snake in your yard. 1-877-Kars4Kids. Crash documentary on Netflix. Duji's kid wants to skip school.See omnystudio.com/listener for privacy information.

Apparently younger men are absolutely feral for confident older women

Send us Fan MailIn this episode of Causes or Cures, Dr. Eeks speaks with Dr. Judson Brandeis, a board-certified urologist, sexual medicine specialist, surgeon, author, and founder of BrandeisMD, about erectile dysfunction, sexual wellness, aging, intimacy, and the rapidly growing men's penile enhancement industry.Dr. Brandeis discusses his recent clinical research exploring whether nitric oxide boosting supplements may work synergistically with medications like Viagra to improve erectile function, as well as broader issues surrounding circulation, lifestyle, vascular health, mental health and sexual performance.He also describes 10 things men can do right now to improve their sexual health.The conversation explores:What causes erectile dysfunction (ED) and why it becomes more common with agingThe role blood flow and nitric oxide play in erectionsHow ED can sometimes signal broader cardiovascular, metabolic or psychological issuesThe difference between prescription ED drugs and supplementsSide effects and limitations of Viagra and CialisShockwave therapy and other emerging approaches in sexual medicine “Sexspan” and maintaining sexual health later in life  Relationship dynamics, intimacy, and communication  Men understanding women's bodies and sexuality after menopause  The psychology and emotional impact of erectile dysfunction  Concerns surrounding the supplement industry and “male enhancement” products The difference between FDA approved medications and dietary supplementsDr. Brandeis also discusses his “P-Long” protocol, which he describes as a safe and effective way to increase the length, girth and function of a healthy man's penis.Dr. Judson Brandeis is a board-certified urologist, surgeon, medical researcher, author, and physician educator with more than 25 years of experience in urology and men's sexual health. Over his career, he has performed thousands of surgeries, helped pioneer surgical robotics, and served as Chief of Urology at John Muir Hospital and Hill Physicians for over a decade. Dr. Brandeis attended Brown University, earned his MD from Vanderbilt University, received a Howard Hughes research award at Harvard Medical School, and completed his surgery and urology residency at UCLA. In recent years, his work has focused on men's wellness, sexual medicine, erectile function, intimacy, and “sexspan,” with an emphasis on helping men improve quality of life, physical intimacy, and overall health as they age.You can learn more about Dr. Brandeis and his work at:BrandeisMDWork with me? Perhaps we are a good match. Keep Causes or Cures Ad-Free with Listener SupportYou can contact Dr. Eeks at bloomingwellness.com.Follow Eeks on Instagram here.Follow Public Health is WeirdOr Facebook here.On Youtube.Or TikTok.SUBSCRIBE to her Newsletter here! (the bits not posted on socia media)Support the show

A conversation with Dr. Arthur Burnett“Optimizing sexual function is one of the most important things men can do to increase their overall health and happiness.”We welcome Dr. Arthur Burnett to the conversation, one of the world's leading urological surgeons, educators and a pioneer in surgery and men's health.His discovery of the role of Nitric Oxide in the erectile function helped make Viagra possible, his surgical work transformed prostate cancer care, and his career has consistently challenged how medicine treats men's bodies and concerns. Who better to talk us through how stigma and silence are shaping men's health outcomes?It's time to talk.—We spoke about why sexual health is one of the most overlooked warning signs in modern medicine, how time-limited primary care visits mean physicians avoid sexual health conversations, how men's reluctance to seek care is reinforced, not corrected, by the system, and how access gaps disproportionately affect Black men and marginalized groups.Follow me on Instagram and Facebook @ericfethkemd and checkout my website at www.EricFethkeMD.com. My brand new book, The Privilege of Caring, is out now on Amazon! https://www.amazon.com/dp/B0CP6H6QN4

This week we discuss the relevance of mascots in professional sports. Do they even have a place anymore and should they persist?For our This Week In Baseball, we discuss Cy Young reaching 500 wins. This milestone is bonkers and will never be surpassed, but just how unreachable is it?Our Hall of Famer this week is Cleveland Pitcher Bob Lemon. Was his good stretch good enough to warrant a place in Cooperstown next to his rotation mate?In our singlular parting shot this week discusses the post-Thomson firing resurgence of the Phillies and if they dug themselves too big a whole to recover this season.Enjoy our new crop of weekly commercials featuring Barbasol, William Frawley for Major League Baseball, and Rafael Palmeiro for Viagra.Please join us as we discuss baseball topics and we continue our mission to make The Hall small. We hope you'll enjoy the ride.TimestampsThis Week In Baseball - 15:07Hall of Fame Discussion - 29:13Parting Shot - 45:54

Carl Johnson grew up in the streets of Baltimore during the same era HBO was filming The Wire — but while the world watched the show, Carl lived the reality. In this episode, Carl breaks down what The Wire got right and wrong, how Baltimore's open-air drug markets really operate, why the city became such a major heroin and fentanyl hub, and how the collapse of the old street-code changed the game forever. He also opens up about his own past in the streets, his mentor's connection to the real Barksdale family, the violence that shaped Baltimore's reputation, and why fentanyl has made today's drug trade more dangerous than ever. Now out of the game, Carl works in recovery and helps others struggling with addiction through the Baltimore Recovery Alliance. This is a raw, unfiltered look inside one of America's most infamous cities — from someone who survived it and turned his life around. We all watched The Wire. Carl Johnson lived it. Go Support Carl! Recovery Program: https://baltimorerecoveryalliance.com/ This Episode Is #Sponsored By The Following: Hims! To get simple, online access to personalized, affordable care for ED, Hair Loss, Weight Loss, and more, visit https://hims.com/connect Prescription required. See website for details and important safety information. Sildenafil is the generic version of Viagra®. Viagra® is a registered trademark of Viatris Specialty LLC. Hims is not affiliated with or endorsed by Viatris. Join The Patreon For Bonus Content! https://www.patreon.com/theconnectshow 00:00 Meet Carl: From Baltimore Streets to Rehab Counselor 03:45 Intro: The Wire & Baltimore's Unique Drug Market 07:07 Fentanyl Takes Over: Shifts in Baltimore's Drug Trade 13:47 Opiates, Rehab, and Open Air Markets 24:33 How the Drug Game Runs: Corners, Crews, and the Feds 32:14 Baltimore's Changing Landscape: Projects, Gentrification 38:11 This Episode Is Sponsored By Hims 39:47 Abandoned Buildings and Homicide Culture 50:25 Guns, Violence, and Life on the Corners 01:03:41 Life Lessons from the Streets: The Barksdale Legacy 01:11:15 Getting Into the Game: Carl's Early Hustles 01:19:55 Crack vs. Heroin: Insider Secrets, Hustle Hierarchies & Survival 01:34:32 Prison, Probation, and the Turning Point 02:05:31 Rehab, Redemption & Breaking Cycles 02:21:55 Addiction, Policy & Baltimore Recovery Alliance Learn more about your ad choices. Visit podcastchoices.com/adchoices

Emer McLysaght and Sarah Breen discuss with Ivan six things which they think should be better known. Emer McLysaght & Sarah Breen are co-authors of the Aisling series. Oh My God, What a Complete Aisling was the bestselling fiction title of 2017 in Ireland and its sequel, The Importance of Being Aisling, won the award for best popular fiction book at the 2018 Irish Book Awards. The third book in the series, Once, Twice, Three Times an Aisling, won the same award the following year and the fourth book in the series, Aisling and the City, won again in 2021. The final book in the series, Aisling Ever After, was published in Autumn 2023 and was an instant number one bestseller. Combined, the Aisling books have sold more than 400,000 copies to date. Their new novel is Our Deadly Summer, which is available at https://www.waterstones.com/book/our-deadly-summer/emer-mclysaght/sarah-breen/9781526692153. In 2015 Ireland legalised a number of Class A drugs for 24 hours because of a loophole in legislation. An Irishman invented cheese and onion crisps at his kitchen table in 1954 The Irish language Nearly all the world's Viagra is made in a small Irish town  Ireland is the only country in the world to have had a female, democratically elected head of state be succeeded by another female, democratically elected head of state, and both were called Mary  Republic of Loose This podcast is powered by ZenCast.fm

Ross Stevenson and Hamish McLachlan are on a desperate search for a sponsor and may have just found the answer! And no.... it's not Hame's suggestion of Viagra.PLUS Hame is in the market for Ross' latest underperforming Horse. GET INVOLVED EMAIL: twoeachway@taptmedia.com.au FOLLOW us on Instagram! TWO EACH WAY INSTAGRAMSee omnystudio.com/listener for privacy information.

Ross Stevenson and Hamish McLachlan are on a desperate search for a sponsor and may have just found the answer! And no.... it's not Hame's suggestion of Viagra.PLUS Hame is in the market for Ross' latest underperforming Horse. GET INVOLVED EMAIL: twoeachway@taptmedia.com.au FOLLOW us on Instagram! TWO EACH WAY INSTAGRAMSee omnystudio.com/listener for privacy information.

La sérendipité, c'est le fait de découvrir quelque chose d'extrêmement important… alors qu'on cherchait autre chose. Le mot vient d'un vieux conte persan, Les Trois Princes de Serendip, dans lequel les héros font des découvertes heureuses par hasard grâce à leur sens de l'observation.Et l'histoire des sciences regorge de découvertes nées de ce type d'accident.Le cas le plus célèbre est sans doute celui de la Pénicilline. En 1928, Alexander Fleming étudie des bactéries lorsqu'il remarque qu'une moisissure a contaminé une de ses boîtes de laboratoire. Normalement, cela devrait ruiner l'expérience. Mais Fleming observe quelque chose d'étrange : autour de la moisissure, les bactéries ont disparu. Il vient sans le savoir de découvrir le premier antibiotique moderne, qui sauvera des dizaines de millions de vies.Autre exemple fascinant : le four à micro-ondes. Dans les années 1940, l'ingénieur Percy Spencer travaille sur des radars militaires lorsqu'il remarque qu'une barre chocolatée dans sa poche a fondu près d'un appareil émettant des micro-ondes. Intrigué, il teste du maïs… qui éclate en pop-corn. Le micro-ondes est né.La sérendipité est également à l'origine du Viagra. Au départ, les chercheurs développent cette molécule pour traiter l'angine de poitrine et l'hypertension. Le médicament fonctionne mal pour le cœur… mais les patients masculins signalent un effet secondaire inattendu particulièrement marqué. Les chercheurs comprennent rapidement le potentiel commercial gigantesque de cette “erreur”.Même les célèbres Post-it résultent d'un accident. Chez 3M, un chimiste nommé Spencer Silver tente de créer une colle ultra-puissante. Il obtient exactement l'inverse : une colle très faible, repositionnable, qui semble inutile. Des années plus tard, un collègue réalise qu'elle serait parfaite pour fabriquer des marque-pages adhésifs. Les Post-it deviennent un produit mondial.Enfin, impossible de ne pas citer les rayons X. En 1895, Wilhelm Röntgen expérimente avec des tubes électriques lorsqu'il remarque qu'un écran fluorescent s'illumine mystérieusement à distance. Il comprend qu'un rayonnement inconnu traverse certains matériaux… y compris le corps humain. Quelques semaines plus tard, il réalise la première radiographie de l'histoire : la main de sa femme.Ces découvertes rappellent une chose essentielle : dans la science, le hasard favorise surtout les esprits capables de remarquer l'inattendu. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Houston street hustler Jugg sits down with to tell the unbelievable story of how he helped fuel the hydrocodone pill explosion across Louisiana and Texas during the early opioid epidemic. From moving thousands of pills a week out of Houston pain clinics to watching entire communities fall into addiction, Jugg gives a raw firsthand account of the rise of “lean culture,” pill trafficking, doctor shopping, Roxy 30s, and the transition into today's fentanyl crisis. In this interview, Jugg breaks down: -How Houston pain clinics operated during the opioid boom -Making millions trafficking hydrocodone and Roxy pills -Drug culture in Houston and Louisiana in the 2000s -The rise of lean, syrup, and pill addiction -Corrupt clinics, pharmacies, and doctor shopping -Prison, street politics, and surviving the game -Why fentanyl changed everything -His life after prison running trucking businesses and podcasts This is one of the wildest untold stories from the Southern opioid epidemic — straight from someone who lived it. Go Support Jugg! IG: https://www.instagram.com/juggwdh YouTube: @wdhtv2 This Episode Is #Sponsored By Superpower! Head to https://superpower.com and use code CONNECT at checkout for $20 off your membership. Unlock your new health intelligence. 100+ biomarkers. Every year. Detect early signs of 1,000+ conditions. #superpowerpod Hims! To get simple, online access to personalized, affordable care for ED, Hair Loss, Weight Loss, and more, visit https://hims.com/connect Prescription required. See website for details and important safety information. Sildenafil is the generic version of Viagra®. Viagra® is a registered trademark of Viatris Specialty LLC. Hims is not affiliated with or endorsed by Viatris. Hell Fresh! Go to https://hellofresh.com/connect10fm now to Get 10 Free Meals + a Free breakfast for Life! One per box with active subscription. Free meals applied as discount on first box, new subscribers only, varies by plan. That's HelloFresh dot com slash connect10fm to Get 10 Free Meals + free breakfast for Life. Join The Patreon For Bonus Content! https://www.patreon.com/theconnectshow 00:00 Ground Floor of the Pill Game 01:45 Introducing Jugg: Origins & Early Hustle 03:30 Family Ties & Teenage Hustling 05:27 Crack, Pills & Generational Drug Shifts 08:17 The Houston Move & Pain Clinics 11:17 The Hydrocodone Boom 14:07 The Pill Market: Operations & Economics 19:07 Scaling Up: Distribution, Profits & Players 20:45 This Episode Is Sponsored By Superpower 232:29 From Weed to Pills: Business Evolution 28:07 Doctor Shopping & Law Enforcement Crackdown 29:56 This Episode Is Sponsored By Hims 31:38 Switching to Roxys & New Market Challenges 35:37 Effects on Community & Pill Culture 39:34 This Episode Is Sponsored By Hello Fresh 41:05 The Pharmacy System & Regulatory Changes 45:07 Crossing Over: Racial Lines & Generational Impact 48:57 Legal Troubles & Escalating Risks 53:07 Prison Time & Lessons Learned 01:00:17 Fake Pills & Fentanyl Danger 01:04:57 Rap Life vs. Hustle Life 01:10:47 Life after the Game: Trucking & Entrepreneurship 01:14:57 Logistics, Trucking, and Felon-Friendly Careers 01:19:17 Reflections, Community & Closing Thoughts Learn more about your ad choices. Visit podcastchoices.com/adchoices

Bruce Bruce jokes about Viagra in his Netflix special, "I Ain't Playin'".

Your low testosterone may not be caused by aging as much as you think. Hidden inflammation, poor sleep, and even your daily eating habits could be quietly destroying your hormone levels without you realizing it.In this episode, you will discover the biggest natural testosterone boosters that actually work and why many men focus on the wrong solutions first. You will also learn when lifestyle changes may no longer be enough and how your body changes with age. If you want more energy, better performance, and real answers about your hormone health, this episode is one you cannot afford to miss.Tune in now and learn how to take control of your testosterone naturally.--------------Key TakeawaysViagra often fails due to improper use.Timing is critical for best results.High-fat meals reduce effectiveness.Wait at least one hour after eating.Give it six to eight proper attempts.Avoid increasing dosage without guidance.Follow a consistent protocol every time.Confidence improves with repeat success.Not all men respond to Viagra.Address root causes for long-term results.--------------Resources mentioned:Viagra Checklist for Lasting VitalityModern Man CribMediterranean DietGood Morning Wood SmoothieRenew with Dr. Anne--------------Curious about how you can boost your bedroom game and build lasting confidence? Check out the course at getwoodnow.com and start your journey to feeling like yourself again!--------------If you enjoyed this episode and want to learn more and get more tips, subscribe to The Modern Man newsletter for exclusive content delivered straight to your inbox! https://dranne.co/themodernman--------------Follow Me On:InstagramTwitterFacebookTikTokYouTube--------------For all links and resources mentioned on the show and where to subscribe to the podcast, please visit https://truongrehab.com/natural-testosterone-boost-men-health--------------Want to regain control of your sex life? It's time to reverse the effects of ED on your life. Join the Modern Man Club and embark on your journey to complete recovery and community.--------------Reveal the FREE treatment most men ignore that solves thousands of erectile dysfunction cases every year, plus the 5 biggest mistakes you must avoid if you want to say goodbye to your ED. Uncover it all in my free eBook, available to download now.https://dranne.co/ebook

Here's a meandering mess of a conversation all about nothing, AI, Baristas, Kindness, Free Burritos, Viagra, Chocolate Supplements and so much more. Please blame AI for how far off the rails this goes. Enjoy! 

JB has a massive story for the Saturday Rub, but first Bily gets us underway with the All Sports Report - including a welcome Government backflip. Two-Time North Melbourne Premiership star Glenn Archer joins the boys ahead of the 1996 Premiership reunion this weekend - and to find the whereabouts of his missing 300th game jumper. Topics Brownless wants to know about your idiot mate, Max Gawn is in studio before the Dees take on West Coast, and we have an Idiot Song themed around Billy's distaste for technology. The best caller of everything Jack Heverin is in with some NBL news - explaining why two coaches have left, and if Patty Mills will play in the NBL. Finally, Billy has a Viagra joke that he's definitely told before... but never this badly.See omnystudio.com/listener for privacy information.

The boys are back and waste no time on the JP Morgan fiasco featuring an office sex slave, Viagra pellets, and seductive cannons. From there it's full clown world: a Kamala donor sprints through a metal detector at the White House Correspondents' Dinner waving a shotgun while the President, VP, and half the succession line sip cocktails in the same Hilton where Reagan got shot. Then a California winery millionaire gets trampled to death by the very elephants he flew to Africa to murder for sport. Nature keeps receipts. And because the week wasn't deranged enough, Iran, with its navy gone and economy on life support, decides dolphin suicide bombers are the answer.

It started with a gut feeling… and a suspicious pill bottle.

It started with a gut feeling… and a suspicious pill bottle.

Something feels off, and the results you expected just aren't happening. You followed the instructions, took the pill, and still ended up frustrated and confused.The truth is, there's a hidden pattern most men completely miss when using ED medication, such as Viagra, and it changes everything. Once you understand it, the difference can be immediate and surprisingly simple. This episode uncovers the exact mistakes that quietly sabotage your results and shows you how to turn things around fast.Tune in now and discover what's really going on behind the scenes.--------------Key TakeawaysViagra often fails due to improper use.Timing is critical for best results.High-fat meals reduce effectiveness.Wait at least one hour after eating.Give it six to eight proper attempts.Avoid increasing dosage without guidance.Follow a consistent protocol every time.Confidence improves with repeat success.Not all men respond to Viagra.Address root causes for long-term results.--------------Resources mentioned:Viagra Checklist for Lasting VitalityModern Man CribMediterranean DietGood Morning Wood SmoothieRenew with Dr. Anne--------------Curious about how you can boost your bedroom game and build lasting confidence? Check out the course at getwoodnow.com and start your journey to feeling like yourself again!--------------If you enjoyed this episode and want to learn more and get more tips, subscribe to The Modern Man newsletter for exclusive content delivered straight to your inbox! https://dranne.co/themodernman--------------Follow Me On:InstagramTwitterFacebookTikTokYouTube--------------For all links and resources mentioned on the show and where to subscribe to the podcast, please visit https://truongrehab.com/viagra-not-working-fix-protocol--------------Want to regain control of your sex life? It's time to reverse the effects of ED on your life. Join the Modern Man Club and embark on your journey to complete recovery and community.--------------Reveal the FREE treatment most men ignore that solves thousands of erectile dysfunction cases every year, plus the 5 biggest mistakes you must avoid if you want to say goodbye to your ED. Uncover it all in my free eBook, available to download now.https://dranne.co/ebook

A todo hombre adulto nos pega la curiosidad de saber qué se siente tomar la pastilla azul u alguna otra que te fortalezca al amigo. Pues bien hoy te diremos las reales consecuencias de abusar de estas pastillas y lo que puedes hacer para reemplazarlas de forma natural. Mantente al día con los últimos de 'El Bueno, la Mala y el Feo'. ¡Suscríbete para no perderte ningún episodio!Ayúdanos a crecer dejándonos un review ¡Tu opinión es muy importante para nosotros!¿Conoces a alguien que amaría este episodio? ¡Compárteselo por WhatsApp, por texto, por Facebook, y ayúdanos a correr la voz!Escúchanos en Uforia App, Apple Podcasts, Spotify, y el canal de YouTube de Uforia Podcasts, o donde sea que escuchas tus podcasts.'El Bueno, la Mala y el Feo' es un podcast de Uforia Podcasts, la plataforma de audio de TelevisaUnivision.

The "mothership" of American finance is currently weathering a storm of graphic allegations and legal counter-punches. In this episode of Chaos Culture Radio, we break down the high-profile lawsuit filed by former JPMorgan analyst Chirayu Rana against Executive Director Lorna Hajdini.While the initial headlines painted a picture of "sexual slavery" and drugging, new details from the bank and Hajdini's defense team suggest a much more complex story of workplace dynamics and a failed multimillion-dollar exit package.In this episode, we discuss:The "John Doe" Reveal: How the anonymous accuser was identified as 35-year-old Chirayu Rana and why he left his new job just weeks before filing this suit.The Graphic Allegations: Breaking down the claims of "Rohypnol and Viagra" drugging, racial slurs like "Asian fish head," and the alleged coercion that Rana claims turned him into a "sex slave."The "Socially Awkward" Defense: Why colleagues are describing Rana as competent but "socially awkward," while defending Hajdini as a "top performer" with no direct power over Rana's bonus or promotion.JPMorgan's Internal Probe: Why the bank's HR and legal teams found "no merit" to the claims after reviewing emails and phone records, and why Rana reportedly refused to cooperate with the internal investigation.The "Money Move": Analyzing reports that Rana attempted to negotiate a massive exit package in 2025 before taking his claims to the New York County Supreme Court.The First Amendment & Privacy: How a lawsuit filed under a pseudonym went viral and the impact of "Internet Trial" on corporate reputations.Episode Quote: "Lorna categorically denies the allegations... she has never even been to the location where the alleged assault supposedly took place." — Hajdini's Legal Team.Become a supporter of this podcast: https://www.spreaker.com/podcast/chaos-culture-radio--3078307/support.Follow Chaos Culture Radio for real conversations that move culture forward.New episodes every week.Share this episode with someone who needs to hear it.

A round-up of the main headlines in Sweden on April 30th 2026. You can hear more reports on our homepage www.radiosweden.se, or in the app Sveriges Radio. A round-up of the main headlines in Sweden on April 30th 2026. You can hear more reports on our homepage www.radiosweden.se, or in the app Sveriges Radio.

Send us a text & leave your email address if you want a reply!Is there an actual cure for erectile dysfunction? In this episode, Dr. Jeff Nuziard of Regen Max says yes, and he has a 97% success rate and a patent to back it up. Jeff breaks down why pills like Viagra and Cialis eventually stop working (hint: it is a tissue problem, not a blood flow problem), and walks us through the four-step regenerative protocol that rebuilds erectile tissue from the inside out using shockwave therapy, laser collagen remodeling, testosterone optimization, and a patented stem cell biologic injected directly into the spongiosum. We also get into why this same science applies to women dealing with clitoral atrophy, lost orgasmic sensitivity, and vaginal dryness, plus an honest take on what peptides like PT-141 and GHK-Cu can and cannot do. If you or someone you love has been told to just manage ED rather than fix it, this episode is going to change the conversation entirely.KEY TAKEAWAYS:The real cause of ED is spongiosum tissue degeneration, not poor blood flowTestosterone decline triggers collagen loss, which dries out erectile tissue over timePDE-5 inhibitors (Viagra, Cialis) stop working when there is no tissue left to absorb bloodA four-step regenerative protocol can restore full erectile function, including for post-prostatectomy patientsWomen experience the same tissue breakdown as clitoral atrophy and vaginal relaxation syndrome, and respond even faster to treatmentOral collagen supplements do not reach erectile tissue; direct injection is the only delivery that worksThe full Regen Max program is $10,000 for one year, all-inclusive, with financing availableLINKS, RESOURCES, BLOGS, & VIDEO VERSIONS OF THE EPISODE CAN BE FOUND HERE ROOTED IN DESIRE. A Journey Back to Your Feminine Essence If you're a heart-centered woman ready to embody your femininity, awaken your sacred sexuality, and fall deeply in love with yourself, this immersion is for you. Register: https://www.sexreimagined.com/rooted-in-desire THE MALE GSPOT & PROSTATE MASTERCLASS. This is for you if… You've heard of epic anal orgasms, & you wonder if it's possible for you too. Save 20% Coupon PODCAST20.  AWAKEN AROUSAL OIL LUBRICANT | Reach new levels of intimacy with our arousal oil, formulated for the female body. Once applied, this topical oil works with your body to enhance sensation and "o's," helping you reach states of euphoric pleasure.Support the showFREEBIE- Introduction to Tantric Kissing Video and WorkbookSxR WebsiteDr. Willow's WebsiteLeah's Website 

Tantôt juré, tantôt à l'Elysée, tantôt derrière des platines, SML reçoit sur les fauteuils de camping Kiddy Smile ou Mimi Smize pour les intimesPour venir assister à un enregistrement cliquez super fort sur ce lienCalme toi :Laura Laarman : directrice de production et direction techniqueAntonia Louveau : community managementLucie Meslien : illustration animation Lou Poincheval : chargée de productionCaroline Bérault : illustrations Manon Carrour : vignette Joanna & Gaspar : générique Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

Welcome back to today's Friday Review where I'll be breaking down the best of the week!     I'll be sharing specifics on these topics:     Stainless Steel Blender Jar (product review) Recovery Determines Results (tip of the week) Early Morning Workers (research) Viagra Use for Leigh Syndrome      For all the details tune in to today's Cabral Concept 3724 – Enjoy the show and let me know what you thought!   - - - For Everything Mentioned In Today's Show: StephenCabral.com/3724 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!