Podcasts about melanomas

In this episode, Therese Markow and Dr. Deborah Lang discuss the rise of skin cancer, particularly melanoma, and its causes. Dr. Lang explains that skin cancers are derived from different skin cells: basal cell carcinoma and squamous cell carcinoma, both linked to UV exposure, and melanoma, which can be UV-independent and linked to genetic susceptibility. Dr. Lang emphasizes the importance of early detection and personalized medicine, noting that melanoma can metastasize early. She also highlights the role of genetic mutations in cancer development and the impact of funding cuts on cancer research.    Key Takeaways: There are three major types of skin cancer. About 80% are basal cell carcinomas.  Because we are living longer, we have an increased chance of cancer. However, other reasons for increased skin cancer include increased UV exposure and tanning beds.  We are all born with moles, but if you notice a change or have a lot (such as over 100), it is worth getting them checked out.  Between 5 and 25 minutes of sun exposure per day is enough for your vitamin D production (less for lighter skin). However, sunlight has other benefits for your health and circadian rhythm.    "Melanomas are derived from a different type of cell - from cells that produce pigment called melanocytes. While this type of cancer is much rarer than basal cell carcinoma or squamous cell carcinoma, it is the most lethal type of skin cancer." —  Dr. Deborah Lang   Episode References:  NIH: https://www.nih.gov/  American Cancer Society: https://www.cancer.gov/  Leo Foundation: https://leo-foundation.org/en/    Connect with Dr. Deborah Lang: Professional Bio: https://profiles.bu.edu/Deborah.Lang  LinkedIn: https://www.linkedin.com/in/deborah-lang-691158208/  ResearchGate: https://www.researchgate.net/scientific-contributions/Deborah-Lang-38651370    Connect with Therese: Website: www.criticallyspeaking.net Threads: @critically_speaking Email: theresemarkow@criticallyspeaking.net   Audio production by Turnkey Podcast Productions. You're the expert. Your podcast will prove it.  

Melanoma treatment has advanced significantly over the past decade, and it continues to evolve. In this special Melanoma Monday episode, we are joined by Kendra Rodriguez, PharmD, PGY2 Oncology Pharmacy Resident at UW Medical Center / Fred Hutchinson Cancer Center, to explore where we are now in the treatment landscape—and what's on the horizon.Kendra walks through recent data from the NADINA and SWOG S1801 trials, and shares how care teams can start preparing for the shift in management to the neoadjuvant setting. You'll hear what it takes to manage complex therapies for resectable cutaneous melanoma, and how to engage patients through thoughtful communication and collaboration.CE Activity Description:The purpose of this CE activity is to describe the pathophysiology and literature behind the shift of pharmacotherapeutic management to the neoadjuvant setting in resectable cutaneous melanoma. As novel mechanisms have been sought after and approved within this disease state, attention will be given to assess the clinical utility of the first-in-class tumor-infiltrating lymphocyte, lifileucel, in addition to its logistical considerations requiring multidisciplinary coordination.Learning Objectives:Summarize the pathophysiology behind neoadjuvant treatment in cutaneous melanoma and the literature supporting its useDiscuss the novel agent lifileucel for its efficacy in cutaneous melanoma treatment and the logistics related to its useDisclosures:No relevant financial relationships for the following faculty and reviewers:• Kendra Gee-Rodriguez, PharmD• Ginger Blackmon, PharmD• Daisy Doan, PharmDClaim credit: https://www.lecturepanda.com/r/CutaneousMelanoma

Skin cancer is the most common form of cancer, and melanomas are the most serious form of this disease. “And we project an increase every year of 20 to 30 percent more cases,” said Merve Hasanov, MD, a James skin cancer and melanoma expert whose research focuses on how melanomas metastasize and spread to the brain. In this episode, Hasanov describes how exposure to ultraviolet light from the sun is the leading cause of all the different types of skin cancer, and that family history is another indicator. “Sun exposure creates a cumulative risk over a lifetime and some people, with a fair complexion, are at higher risk,” she said. Precautions that reduce risk “are decreasing your exposure to the sun, using sun block and reapplying every 50 to 90 minutes and avoiding tanning beds, which use UV rays,” Hasanov said. “Wear a hat or long sleeves, and, even when it's cloudy or during the winter the UV rays are coming from the sun.” Advances in treatment have led to better outcomes for patients, especially when melanomas are detected in the earlier stages, before they have metastasized and spread to other parts of the body. Because of this, “it's now recommended that you should, once a year, get a thorough dermatological exam,” Hasanov said, and she also explained the A-B-C-D-E method of detecting skin cancer: asymmetry, border, color, diameter and evolving. Immunotherapy has been a big breakthrough for the treatment of melanomas. “Melanomas have a lot of molecular and genetic changes that can be recognized by the immune system,” she explained. “But cancer cells are smart and can shut down the immune system. But immune checkpoint inhibitors [in immunotherapy drugs] take the brakes off the immune system so the T cells better recognize and kill cancer cells.” Hasanov said that the melanomas in 10 to 12 percent of patients diagnosed in the early stages of their disease will eventually metastasize and travel to the brain. “My research focuses on detecting this earlier when we have better treatment options and survival rates,” she said. Hasanov and her lab have developed a scoring system to determine which early-stage melanoma patients are most likely to develop brain metastasizes. These patients can then be screened on a regular basis. “We're hoping that this information will lead to better guidelines and trying to spread this information to more physicians and oncologists.”

El melanoma es una de las manifestaciones de la piel más peligrosas que pueden tener su origen en un exceso de exposición al sol, pero no es el único peligro. De cuidades estivales y enfermedades asociadas al sol hablamos esta noche con Rebeca Gonzáles Guerrero, investigadora en el Centro Mediterráneo de Medicina Molecular en Niza (Francia). Con nuestra sección de naturaleza del catedrático José Luis Viejo, más noticias y la canción de la invitada terminamos el programa.Escuchar audio

In this third episode of the Rash Decisions melanoma series, Dr George Moncrieff and Dr Roger Henderson guide you through "The Art of Melanoma Spotting" in primary care. They'll upskill you on the essential techniques for early melanoma detection, emphasising the key role of dermatoscopy and mole mapping. Our experts also share their thoughts on UVA and UVB exposure whilst exploring the complexities of sunblock usage, debunking common myths and providing practical advice for you to pass on to your patients.  Tune in to gain the expertise needed to spot early melanomas confidently and improve patient outcomes in your practice.   Thank you to our kind sponsor AproDerm, who provide a comprehensive range of quality emollients designed for the management of dry skin conditions, including eczema, psoriasis and ichthyosis.   To simplify the process of finding the most suitable emollient for each patient, they have developed a remarkable solution: the AproDerm Emollient Starter Pack. This pack conveniently combines all four of their emollients in a single prescription, enabling patients to identify their ideal emollient more efficiently, aiding both compliance and adherence.   Find out more: https://aproderm.com/aproderm-emollient-starter-pack/    LI: https://www.linkedin.com/company/fontus-health-ltd/   Got some feedback for us? Please rate and review Rash Decisions to help us keep creating educational podcasts for you.   Is there a dermatology topic you'd like us to explore? Email us at info@aproderm.com, and we'll do our best to cover it.  The views expressed in this podcast are of Dr George Moncrieff and Dr Roger Henderson. Fontus Health has not influenced, participated, or been involved in the programme, materials, or delivery of educational content.  Episode Resources:   Reduced Melanoma After Regular Sunscreen Use: Randomized Trial Follow-Up: https://ascopubs.org/doi/10.1200/JCO.2010.28.7078  

Do you use ABCD to diagnose malignant melanomas? You may be contributing to the 84% of obviously benign melanomas that are referred to secondary care. Or even worse, you could be missing over two thirds of melanoma.  Dr George Moncrieff and Dr Roger Henderson scrutinise ABCD in this podcast episode, working through each letter of the acronym to decipher the helpfulness of distinguishing malignant melanomas from benign lesions in primary care and explaining how much more useful E, F and G are.   When you finish this episode you'll feel more confident in your diagnosis with Dr Moncrieff's comprehensive diagnostic criteria. In addition, you'll find out when you need to decide the next steps on a lesion immediately and where you have 3 to 4 months to make a decision. Thank you to our kind sponsor AproDerm, who provide a comprehensive range of quality emollients designed for the management of dry skin conditions, including eczema, psoriasis and ichthyosis.   To simplify the process of finding the most suitable emollient for each patient, they have developed a remarkable solution: the AproDerm Emollient Starter Pack. This pack conveniently combines all four of their emollients in a single prescription, enabling patients to identify their ideal emollient more efficiently, aiding both compliance and adherence.   Find out more: https://aproderm.com/aproderm-emollient-starter-pack/    LI: https://www.linkedin.com/company/fontus-health-ltd/   Got some feedback for us? Please rate and review Rash Decisions to help us keep creating educational podcasts for you.   Is there a dermatology topic you'd like us to explore? Email us at info@aproderm.com, and we'll do our best to cover it.  Episode Resources:   Survival with nonmelanoma skin cancer in Germany: https://pubmed.ncbi.nlm.nih.gov/26676514/   The views expressed in this podcast are of Dr George Moncrieff and Dr Roger Henderson. Fontus Health has not influenced, participated, or been involved in the programme, materials, or delivery of educational content.   

“Over half of all our referrals to dermatology are for suspected skin cancer.  But this is the alarming thing, only 6% of those referrals turn out to be either a melanoma or a squamous cell carcinoma...” Dr George Moncrieff.  So, as primary care physicians, how can we help to reduce the percentage of benign melanoma referrals?  You can start by listening to this podcast where your hosts Dr George Moncrieff and Dr Roger Henderson discuss:   The current incidence statistics for malignant melanomas and how these have changed over the past 5 decades  Who is actually at risk? Looking at genetic make-up, age, gender, skin colour, hair colour and family history  External risk factors, including ultraviolet light, explaining the difference between UVA and UVB  Our approach to diagnosis, questioning if ABCDE is dangerously flawed.  “Everyone expects us to get this one right”, (Dr Moncrieff), so this podcast episode is not one to be missed!  Thank you to our kind sponsor AproDerm, who provide a comprehensive range of quality emollients designed for the management of dry skin conditions, including eczema, psoriasis and ichthyosis.   To simplify the process of finding the most suitable emollient for each patient, they have developed a remarkable solution: the AproDerm Emollient Starter Pack. This pack conveniently combines all four of their emollients in a single prescription, enabling patients to identify their ideal emollient more efficiently, aiding both compliance and adherence.   Find out more: https://aproderm.com/aproderm-emollient-starter-pack/    LI: https://www.linkedin.com/company/fontus-health-ltd/   Got some feedback for us? Please rate and review Rash Decisions to help us keep creating educational podcasts for you.   Is there a dermatology topic you'd like us to explore? Email us at info@aproderm.com, and we'll do our best to cover it.  The views expressed in this podcast are of Dr George Moncrieff and Dr Roger Henderson. Fontus Health has not influenced, participated, or been involved in the programme, materials, or delivery of educational content.  Episode Resources:   International Prevalence of Indoor Tanning: A Systematic Review and Meta-analysis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4117411/  An Exploration of the Use and Impact of Preventive Measures on Skin Cancer: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9025621/   Association of UV Radiation Exposure, Diagnostic Scrutiny, and Melanoma Incidence in US Counties: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531098/    

En el Día Mundial del Melanoma, tenemos la oportunidad de profundizar en un tema crucial para la salud pública: el melanoma, un tipo agresivo de cáncer de piel. Que aún hoy sigue siendo un desconocido para los ciudadanos .

En el Día Mundial del Melanoma, tenemos la oportunidad de profundizar en un tema crucial para la salud pública: el melanoma, un tipo agresivo de cáncer de piel. Que aún hoy sigue siendo un desconocido para los ciudadanos.

Šomēnes startējusi kampaņa „Stājies saulessardzē”, kas neaicina sargāt sauli, bet tieši otrādi - pasargāt sevi no saules stariem. Tās laikā ikviens tiek aicināts simboliski stāties saulessardzē un mācīties, kā sevi un savus tuvos pasargāt no saules starojuma kaitīgās ietekmes. Par melanomas mēneša pasākumiem un ādas vēža profilaksi saruna raidījumā Kā labāk dzīvot. Raidījuma viešņas: biedrības „Soli priekšā melanomai dibinātāja Sondra Zaļupe, dermatologs, biedrības "Dermatologi pret ādas vēzi" valdes priekšsēdētājs, "Derma Clinic Riga" valdes priekšsēdētājs Raimonds Karls un dermatoloģe Anda Apine. Raimonds Karls vērtē, ka cilvēku zināšanu līmenis gadu no gada par saules ietekmi ir uzlabojies, bet ir vēl, kur augt. "Ja runājām konkrētāk, ļoti daudzi apzinās, ka saules aizsardzība ir vajadzīga, daudzi apzinās, ka saulē nevajadzētu būt dienas vidū. Tās ir aksiomas, ko atkārtojam. Bet ir jāiet tālāk, ir arī jāizglīto iedzīvotāji, kas ir saules ultravioletais indekss, kuram vajadzētu sekot līdzi. Varbūt arī mediji laika ziņās šajās saulainajās dienās varētu informēt, pasakot: "Šodien saules ultravioletais indekss ir augsts." Tālāk mums būtu jāizglīto, ko nozīmē augsts, ko nozīmē vidējs un kāda būtu darbība katrā no šīm situācijām," norāda Raimonds Karls. Ārsts arī norāda, ka mēs dzīvojam nelielā ilūzijā par to, ka saules pie mums nav, ka esam bāli.  "Jāsaprot, ka dienas vidū arī Latvijā saules ir daudz. Paskatieties, mēs visur esam salikuši saules kolektorus un baterijas un iegūstam gana daudz saules šajos mēnešos," norāda Raimonds Karls. Nevajadzētu plānot tagad doties uz siltajām zemēm un pavadīt laiku pludmalē no rīta līdz vakaram, un ja es nebūšu apdedzis, mans atvaļinājums nebūs izdevies. "Vēl viens liels mīts, kas mums ir, ka saule un D vitamīns ir ļoti vienāds. D vitamīna ražošana un iedegums ir pretēji proporcionāli - D vitamīns mūsu ādā veidojas, kamēr mēs vēl neesam ieguvuši iedegumu. Kad esam iedeguši, šī stacija veras ciet, jo dabīgi āda ir iekārtota tā, ka D vitamīna ražotne samazinās. Nevajag arī šo mītu izmantot kā advokātu, kāpēc es tik daudz laika pavadu saulē," skaidro Raimonds Karls. Arī jebkura darbošanās saulē - zāles pļaušana, sportošana - ir saules staru uzkrāšana.

Uber for Dog-Walkers Tobi Skovron has created an App that will summon a vetted dog-walker. He touts his high-end service as the next step in the evolution of pet-based technology. Listen Now Protecting Your Pet From The Sun Our pets are at a higher risk than we are for sun-related Melanomas. You need to protect them from the sun, even if they're indoor animals. Dogfather Joey Villani and Dr. Debbie share what you need to know for your pet's safety and well being. Listen Now 10-Year-Old Hero This week's Hero Person will charm you! She's just a little girl. But she has a huge heart for the animals. Samantha Frenck created a 501c3 non-profit that brings toys and blankets, among other things, to shelter animals. Listen Now Pet Friendly Cities Forbes went in search of America's most pet-friendly places to live. The criteria included having the best landlords, lowest pet fees and most pet specialty stores and services. You might be surprised which city topped the list. Listen Now Pet Store Switch What happens when you switch the pets in a pet store for animals from a shelter? Would the customers notice? A pet store in Brazil partnered with local pet shelters to secretly switch those pricey purebreds for rescues. Then the store went a step further and simply gave the shelter pets away to worthy families. Listen Now Read more about this week's show.

QIMR Berghofer researchers have found that nearly a third of melanomas picked up during routine skin checks may not be harmful.The findings highlight the need for further research to determine why some melanomas appear to stay dormant and undetected for long period of time.It also may lead to more accurate diagnostic tools which might spare some people the anxiety associated with a melanoma diagnosis. Professor David Whiteman, who led the study, said the results suggest up to 29 per cent of melanomas detected during skin checks may never have come to light if that person wasn't screened.

There is a lot of confusion and controversy around sun and melanoma. Should you avoid the sun, or should you try to get more sun? Find out. Dr. Berg's Keto and IF Lab: https://www.facebook.com/groups/drbergslab/ How to Bulletproof your Immune System FREE Course: https://bit.ly/39Ry3s2 FREE MINI-COURSE ➜ ➜ Take Dr. Berg's Free Keto Mini-Course! ADD YOUR SUCCESS STORY HERE: https://bit.ly/3z9TviS Find Your Body Type: https://www.drberg.com/body-type-quiz Talk to a Product Advisor to find the best product for you! Call 1-540-299-1557 with your questions about Dr. Berg's products. Product Advisors are available Monday through Friday 8 am - 6 pm and Saturday 9 am - 5 pm EST. At this time, we no longer offer Keto Consulting and our Product Advisors will only be advising on which product is best for you and advise on how to take them. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. Dr. Berg's Website: http://bit.ly/37AV0fk Dr. Berg's Recipe Ideas: http://bit.ly/37FF6QR Dr. Berg's Reviews: http://bit.ly/3hkIvbb Dr. Berg's Shop: http://bit.ly/3mJcLxg Dr. Berg's Bio: http://bit.ly/3as2cfE Dr. Berg's Health Coach Training: http://bit.ly/3as2p2q Facebook: https://www.facebook.com/drericberg Messenger: https://www.messenger.com/t/drericberg Instagram: https://www.instagram.com/drericberg/ YouTube: http://bit.ly/37DXt8C Pinterest: https://www.pinterest.com/drericberg/

CME credits: 2.25 Valid until: 12-10-2023 Claim your CME credit at https://reachmd.com/programs/cme/panel-critical-considerations-in-the-use-of-icis-in-high-risk-resectable-melanomas/14380/ tbd

The summer months can be exciting for those who had a harsh winter season. Be careful with the sun exposure and learn more to help maintain healthy skin. Take advantage of an exclusive podcast offer today by visiting http://www.invitehealth.com/podcast. For more information on the products or studies mentioned in this episode, as well as a complete transcript of the audio, click here

In this podcast we will cover the basics of melanomas which all general practcioners should know about with Mayuri Ramnarain.

In this podcast we will cover the basics of melanomas which all general practcioners should know about with Mayuri Ramnarain. Stanleur Capital: Medical practice and personal financial solutions

Muskuļi cilvēka ķermenī ikdienas veic darbu, kuru mēs nereti uztveram kā pašsaprotamu. Kā darbojas muskuļi mūsu ķermenī un kā mēs ar savu dzīves veidu varam veicināt vai arī apgrūtināt to darbu, raidījumā Zināmais nezināmajā skaidro Latvijas Universitātes Sporta zinātnes programmas vadītāja, asociētā profesore Līga Plakane. Tapusi jauna bezkontakta melanomas skrīninga iekārta Ādas vēža jeb melanomas savlaicīga diagnostika ir viens no būtiskākajiem nosacījumiem, lai to veiksmīgi ārstētu. Medicīnā jau tiek lietoti dermatoskopi ādas veidojumu pārbaudei, taču nesen pētnieku komanda nākusi klajā ar jaunu bezkontakta melanomas skrīninga iekārtu. Tā ļautu veikt precīzu, vienkāršu un ātru ādas veidojumu analīzi jebkuram lietotājam bez iepriekšējām zināšanām. Kā tad iekārta darbotos un kam tā īpaši noderētu? Par multispektrālu bezkontakta melanomas skrīninga iekārtu stāsta jaunuzņēmuma “Bdetect” vadītājs, ekonomikas doktora kandidāts Ronalds Skulme, inženierzinātņu doktors Rīgas Tehniskajā universitātē Dmitrijs Bļizņuks, kā arī Latvijas Universitātes Atomfizikas un spektroskopijas institūta Biofotonikas laboratorijas vadošā pētniece Ilze Ļihačova. Saskaņā ar starptautisku publikāciju datiem melanoma ir tas ļaundabīgais audzējs, kas izraisa lielāko daļu ar ādas vēzi saistīto nāves gadījumu. Katru gadu visā pasaulē melanoma izraisa aptuveni 55 000 nāves gadījumu. Ādas veidojumu pārbaudei dermatologi un onkologi lieto dermatoskopus, bet tāpat var rasties grūtības atšķirt, vai tā tiešām ir melanoma, vai arī kāds labdabīgs veidojums. Risinājumu meklējuši arī Latvijas pētnieki, ievācot datus un galarezultātā izstrādājot iekārtu melanomas diagnostikai, kas strādā bezvadu režīmā un piedāvā arī citas tehniskas priekšrocības. Viena no iekārtas izstrādātājiem, pētniece Ilze Ļihačova uzsver tieši ādā esošo pigmentu analīzes nozīmi, lai ieraudzītu melanomu un pieņemtu lēmumu par diagnozi. Šie pigmenti jeb hromoforas ir melanīns, ko redzam dzimumzīmēs, un tās var būt tumši, gaiši, oranžīgi brūnas. Otrs pigments ir hemoglobīns, kas atrodams asins sastāvā. Melanomas skrīninga iekārtu šobrīd piedāvā jaunuzņēmums “Bdetect”. Melanomas skrīninga iekārta prezentēta arī Baltijas biznesa tehnoloģiju izstādē “RIGA COMM”. Plašāku informāciju par iekārtu var iegūt, apmeklējot jaunuzņēmuma mājas lapu.

Australia has one of the highest rates of skin cancer in the world, but a pilot study has found a way to detect melanomas early, with a little help from a smartphone camera.

ASCO 2021 - Melanomas by

Dr. Peter Bittar, MD interviewed by Harrison Nguyen, MD, FAAD

Rūpes par sevi un laicīgs speciālista apmeklējums var novērst draudus ne tikai veselībai, bet arī dzīvībai. Kā pasargāt sevi no melanomas un kā ārstēšanas procesā panākt vislielāko efektivitāti? Kas ir melanoma, kā iespējamo saslimšanu var pamanīt un kur vērsties pēc palīdzības skaidro Rīgas Stradiņa universitātes asociētā profesore, onkoloģe, ķīmijterapeite un imunoloģe Rīgas Austrumu klīniskās universitātes slimnīcā Simona Doniņa un dermatologs, biedrības "Dermatologi pret ādas vēzi" valdes priekšsēdētājs Raimonds Karls. Simona Doniņa norāda, ka noteikti jāpievērš uzmanība jebkuram ādas veidojumam, kas mainās vai parādās no jauna. Diemžēl Latvijā trūkst dermatologu, lai vienkārši profilakses pēc vērstos pie ārsta. Latvijā tāpat kā pasaulē pieaug melanomas pacientu skaits un pieaug arī to cilvēku skaits, kas mirst no ādas vēža. Tā kā viens no veidiem, kā iegūt melanomu ir saules, Raimonds Karls aicina lietot saules aizsarglīdzekļu lietošana. "Ja izvēlamies līdzekļus, ko esam iegādājušies aptiekās, tie ir droši un nekaitīgi. Saules aizsardzībai ir ļoti liela nozīme, sākot no bērna vecuma, pieaugušajiem un arī senioriem," atzīst Raimonds Karls. "Nopirkt ir pirmais solis, lietot ir otrais solis, trešais – jālieto pareizi. Jāatceras, ja no rīta, atnākot uz pludmali, uzklāju saules aizsargkrēmu, tas nenozīmē, ka esmu pasargāts visu dienu." Ārsts arī atgādina, ka arī mērķtiecīgi nesauļojoties, bet dienas vidū darbojoties ārā – dārzā vai sportojot, ir jālieto saules aizsargkrēms. Protams, var izvēlēties tieši dienas vidū neiet saulē, bet Latvijas iedzīvotāji bieži neseko šim ieteikumam. "Mēs paši sev esam radījuši mītu, ka mums ir īsa vasara, ka mums nekas no vasaras nav, mums ir zaļā ziema, bet, ja mēs noliekam kaut vai avīzi uz palodzes, mēs redzam, kas ar to notiek jau vakarā. Ja mēs saulē ejam 50, 60, 70 gadus, iedomājieties, ko āda cenšas izdarīt, lai to visu atjaunotu un šos bojājumus novērstu," vērtē Raimonds Karls. Melanomas pacientu atbalsta biedrības" Soli priekšā melanomai" mārketinga projektu koordinatore Sondra Zaļupe un melanomas pacientu atbalsta biedrības "Soli priekšā melanomai" vadītāja Olga Valciņa stāsta par šī gada Melanomas mēneša norisēm. Par akciju "Balts ir skaisti!" un iespējam pārbaudīt ādas veidojumus stāsts arī programmā Pēcpusdiena. Olga Valciņa bilst, ka vislabākās zāles pret bailēm un nedrošību ir vizīte pie ārsta. Ja melanomu atklāj laicīgi, cilvēkam ir 98 % izredzes, ka cilvēkam vairs nekad par to nebūs jādomā.  

Par melanomas riskiem un ādas aizsardzības no saules stariem nozīmi tiek runāts arvien plašāk, taču neskatoties uz izglītojošo informāciju, melanomas saslimšanu skaits ik gadu turpina pieaugt. Turklāt joprojām pastāv daudz mītu par saules staru iedarbību uz ādu un saules aizsarglīdzekļu lietošanu. Tāpat aktuāls ir jautājums, kā tas ietekmē D vitamīnu uzņemšanu, kas tiek sintezēts ādā, saskaroties ar saules statiem. Par šiem un citiem ar ādas veselību un sauli šajā BENU Akadēmijas podkāsta epizodē runāsim ar ārstu dermatologu, dermatoloģijas klīnikas Derma Clinic Riga vadītāju, Raimondu Karlu, un BENU Aptiekas farmaceiti Baibu Prinduli. Sarunu vada Valdis Melderis.

Chengyu Liang is a world-renowned researcher with almost 17,000 citations. Her research explores basic mechanisms underlying fundamental cellular processes in the development of cancer and infectious disease. In short, Dr Liang is working to understand how to prevent melenomas (skin cancer) - work which has huge implications on the overall goal of defeating cancers. This podcast aims to take Dr Liang's complex research and break it down in to bitesize chunks that you can understand at home. Listen in as we explore the role of melanin in protecting against cancer, the difficulty in establishing risk-factors, and why the issue of skin-cancer doesn't gain as much publicity as it should. Enjoy!

Volume 11 Issue 25 of @Oncotarget reported that this study aimed to define the mutation profile of SUM in Caucasians. Next-generation sequencing-based genomic analysis was used to identify frequently mutated loci in 50 cancer-related genes in 31 SUM primary tumors. The most abundant mutations in SUM were found in KIT – in 13% of cases and NRAS – also in 13%, while BRAF - only in 3% of cases. The authors' findings confirmed a high frequency of KIT and NRAS mutations in SUM, as well as a low incidence of BRAF mutations. They reported novel KRAS, CTNNB1, TP53, ERBB2, and SMAD4 mutations in SUM. Dr. Aneta Borkowska from The Maria Sklodowska-Curie National Research Institute of Oncology said "Across all human cancers, cutaneous malignant melanoma (MM) genome has one of the highest prevalence of somatic mutations." At the same time, NRAS mutations are detected in approximately 20% of MM and are more commonly reported in melanomas developing in the skin with chronic sun exposure. WHO Classification of Skin Tumours recognizes the most common acral melanoma histotype is acral lentiginous melanoma, followed by nodular cutaneous melanoma and superficial spreading melanoma. Cutaneous MM located on the acral part of extremities - hand and foot melanoma - comprises a rare group within all melanomas in Caucasians. Whole-genome sequencing study shown that structural changes and mutational signature of acral melanomas were dominated by different than other MMs sites. SUM seems to be not related to sun exposure, however, in Australian Melanoma Genome Project UVR signatures on acral melanomas occurred most frequently in subungual parts. The Borkowska Research Team concluded in their Oncotarget Research Paper, "Our study offers new insights into the genetics SUM subtype, for understanding pathogenesis and providing potential biomarkers for future studies. Molecular testing is now widely used in patients with advanced melanoma in the process of therapeutic decisions. Mutations reported in melanoma cells provide starting points for the development of the rational design of novel therapies, including immunotherapy agents. They also may provide to find the molecular pathogenesis and natural history of subtypes of this heterogeneous disease. We confirmed that SUM have different than other cutaneous melanomas genetic profile, which due to its rareness and lack of studies should be subjected to further analyzes in multicenter studies." Sign up for free Altmetric alerts about this article DOI - https://doi.org/10.18632/oncotarget.27642 Full text - https://www.oncotarget.com/article/27642/text/ Correspondence to - Aneta Borkowska - anetame@gmail.com Keywords - melanoma, acral melanoma, subungual melanoma, nail apparatus melanoma, SMAD4 About Oncotarget Oncotarget is a weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit http://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact MEDIA@IMPACTJOURNALS.COM 18009220957x105

Katru gadu vairākiem simtiem Latvijas iedzīvotāju tiek atklāts ļaundabīgs ādas audzējs – melanoma. Šīs slimības pacientu atbalsta biedrība „Soli priekšā melanomai” rīko izglītojošu kampaņu "Balts arī ir skaisti". Melanomas pacientu atbalsta biedrības "Soli priekšā melanomai" dibinātāja Sondra Zaļupe norāda, ka maijs ir izsludināts par melanomas mēnesi un biedrība kopā ar dermatolgiem informēs, ka cilvēkiem sevi pasargāt. Biedrības mājaslapā pieejams jaunās kampaņas buklets, kā arī būs vēl papildus informācija, kā sevi pasargāt šajā laikā, kad daudz laika pavadām brīvā dabā, dārzā vai pastaigās. Sondra Zaļupe mudina katram pašam sekot līdzi veidojumiem, kas parādās uz ādas, sargāt sevi no saules, neuzturēties tiešos saules staros, izvēlēties apģērbu ar garām piedurknēm vai starām, nesāt cepuri un saulesbrilles, kā arī lietot saules aizsargkrēmus. Dermatologs Raimonds Karls norāda, ka melanoma uz ādas var attīstīties arī tādās vietās, kas sauli nemaz nav redzējušas. „Nedzīvosim ilūzijā, ka Latvijā nav saules. Latvijā saule ir, ir gana daudz saules. Tas, ka ir vēss, tas nav ekvivalents ultraviolētam starojumam, tas, kas ir vēss, nenozīmē, ka nav ultravioletā starojuma. Nevajag likt vienādības zīmi starp gaisa tempereratūru un ultraviolēto indeksu," skaidro Raimonds Karls. Tāpat ārsts norāda, ka arī dūmakainā laikā ir saule un var just ultraviolēto staru ietekmi.

Talk to a Dr. Berg Keto Consultant today and get the help you need on your journey (free consultation). Call 1-540-299-1557 with your questions about Keto, Intermittent Fasting or the use of Dr. Berg products. Consultants are available Monday through Friday from 8:30 am to 9 pm EST. Saturday & Sunday 9 am to 5 pm EST. USA Only. Take Dr. Berg's Free Keto Mini-Course! Today we're going to talk about sun exposure and melanoma. On the one hand, there's a push to have everyone avoid the sun. On the flip side, 69 % of the population has vitamin D insufficiency. Research indicates that: • Non-burning sun exposure is associated with a decreased risk of melanomas. • Getting too much sun, like a sunburn, is associated with doubling the risk of melanomas. • Outdoor workers have lowered incidences of melanoma than indoor workers. Realize that vitamin D has a protective function that may help protect from the potential damage to your DNA that the sun can cause. Dr. Eric Berg DC Bio: Dr. Berg, 51 years of age is a chiropractor who specializes in weight loss through nutritional & natural methods. His private practice is located in Alexandria, Virginia. His clients include senior officials in the U.S. government & the Justice Department, ambassadors, medical doctors, high-level executives of prominent corporations, scientists, engineers, professors, and other clients from all walks of life. He is the author of The 7 Principles of Fat Burning. FACEBOOK: fb.me/DrEricBerg?utm_source=Podcast TWITTER: http://twitter.com/DrBergDC?utm_source=Podcast YOUTUBE: http://www.youtube.com/user/drericberg123?utm_source=Podcast DR. BERG'S SHOP: https://shop.drberg.com/?utm_source=Podcast MESSENGER: https://www.messenger.com/t/drericberg?utm_source=Podcast DR. BERG'S VIDEO BLOG: https://www.drberg.com/blog?utm_source=Podcast

Today we have a guest from the IGMM, she discusses her project and past internships. The paper reviewed can be found at DOI: 10.1111/pcmr.12743

Melanoma ir ļaundabīgs ādas audzējs, kurš Latvijā ik gadus skar aptuveni 200 cilvēku. Par tā izplatības tendencēm, jaunākajām diagnostikas un ārstēšanās iespējām, kā arī profilaksi runājam raidījumā Kā labāk dzīvot. Raidījuma viesi: dermatologs, Latvijas Dermatoskopijas biedrības priekšsēdētājs Raimonds Karls, ķirurgs onkologs Latvijas Onkologu asociācijas valdes loceklis Guntis Ancāns, medicīnas doktore onkoloģe imunoloģe Simona Doniņa un melanomas pacientes - Sondra Zaļupe un Olga Valciņa. Sondra Zaļupe un Olga Valciņa ir nodibinājušas melanomas pacientu biedrību. Šobrīd ir izzveidota mājas lapa “Soli priekšā melanomai”, kurā aicina anonīmi aizpildīt anketu, kas palīdzētu saprast, cik ir saslimušo un ko kopā var paveikt. Biedrība vēlas veidot tematiskus informatīvus pasākumus kopā ar profesionāļiem, kas var palīdzēt cilvēkiem, kas saslimuši ar melanomu, kas var skaidrot situāciju pacientu līdzcilvēkiem. Biedrības darbības pamatprincipi būs – pacients ir pirmajā vietā, risinājumi, nevis problēmas, dati un fakti, nevis viedokļi un kurš tad, ja ne es. Ar tiem plašāk var iepazīsties arī mājaslapā. Speciālisti atgādina: Latvijā pēdējos 5-7 gadus melanomas slimnieku skaists ir virs diviem simtiem. Problēma ir aktuāla, jo valstī melanomu parasti atklāj vēlīnā stadijā, tas nozīmē sliktāku prognozi ārstēšanai. Galvenie riska faktori: gaiša āda un esam pakļauti ultravioletajam starojumam, gan dabīgam, gan mākslīgam. Āda jāpārbauda agrīni un savlaicīgi. Jo agrāk atklāj ļaundabīgu veidojumu, jo labāk. Viena no pazīmēm, ko min, kas varētu liecināt par melanomu, ir atipiskas dzimumzīmes. Raimonds Karls norāda, ja cilvēkam ir daudz pigmentēto veidojumu uz ādas, tie jāpārbauda, tipisks vai atipisks, lai ar to nodarbojas ārsts. Ādas vēža attīstībai ir divi scenāriji: iepriekš ir bijusi dzimumzīme, kas sākusi mainīties, bet tie ir 15-20% visu gadījumu. Visbiežāk audzējs sākas kā jauns veidojums, kas ar laiku pārvēršas, jo ilgāks laiks paiet, jo aktīvāk audzējs aug. Ārsti reģistrē ap 220 melanomas pacientu gadā, diemžēl zaudē katru gadu ap 90 cilvēku. Bieži melanomu diagnosticē samērā jauniem cilvēkiem. Viņi kūtri apmeklē ārstu, veselībai pievērš mazāk uzmanības. Slimību galvenokārt iegūst dzīves laikā, pārmantojamība ir reta.

Episode 5 features Christopher J. Miller, MD, FACMS, Director of the Penn Dermatology Oncology Center and Associate Professor of Dermatology at the Hospital of the University of Pennsylvania. Dr. Miller discusses two recent studies, Melanomas of the head and neck have high local recurrence risk features and require tissue rearranging reconstruction more commonly than BCC and SCC: A comparison of indications for microscopic margin control prior to reconstruction in 13,664 tumors and The 'Rule of 10s' versus the 'Rule of 2s': High complication rates after conventional excision with postoperative margin assessment of specialty site versus trunk and proximal extremity melanomas. Both were published in the Journal of the American Academy of Dermatology in late 2018.

In this episode, we're joined by MD/PhD student Matthew Dankner to discuss his paper "Dual MAPK inhibition is an effective therapeutic strategy for a subset of class II BRAF mutant melanoma" published in the June 2018 issue of Clinical Cancer Research.

Wow, Sunbeds are emotive! No, not the ones that holiday companys now allow you to book in advance so there's no more running down with the towel early doors on hols to ensure your spot, I mean the electric ones in salons. Why do we find sunbeds so difficult and yet burning on the beach "part of the holiday"? Here, I interview Gill Perkins of The Sunbed Association to get her view on tanning, the risk of Melanomas and a whole host of other things that I did not know about tanning. If you're in the sun this summer, listen to this first. You'll understand why sunburn is just so bad for your skin long term.

Minería de bitcoins, detección precoz de melanomas y marketing digital son los temas de este episodio de Me gustan los lunes. ¿Sabes que es la minería de bitcoins y como es de potente la red de ordenadores que custodian esa cadena de bloques? ¿Como se puede prevenir el cáncer de piel mediante inteligencia artificial y un smartphone? ¿Qué es el márketing digital y que llevo a Juan Merodio a irse a vivir a Toronto? Estos son los temas que puedes escuchar en el episodio treinta y tres de Me Gustan los Lunes Puedes contactar con nosotros en nuestro email: hola@singularshirts.com a través de twitter @SingularShirts por Facebook o a través de nuestra página web https://singularshirts.com Puedes ver los enlaces a los temas que tratamos y la lista con las canciones en el post de este episodio en nuestro blog.

Prof Robert speaks with ecancer at WIN 2017 about tackling class-associated toxicity and drug resistance with combination therapies based on tyrosine kinase inhibition.

Tonight we discussed pigmented things that grow on the skin - moles and melanomas. We also discussed the techniques plastic surgeons use to create better looking scars. We also discussed scar revisions to improve their appearance.

In this podcast episode, Professor Dorothy Bennett discusses her research into cell senescence, melanomas and the related genetics. Melanomas are an aggressive form of skin cancer that develops from moles. Professor Bennett and her colleagues have been investigating the genetics of melanomas and the markers that could help distinguish melanomas, and moles that are developing…

Does your horse have stubborn or unsightly tumors or skin growths, and you're not sure what to do next?

A new twin study compared traditional long scar facelifts with the new short scar versions. Listen to what I say about this important study. We also discussed moles and melanomas. We also discussed sunscreen safety. We also discussed Microneedling for wrinkles.

Skin cancers are really prevalent in Australia. This is a tough and broad subject, but it's also super important! Find out what Squamous cell carcinomas, Basal cell carcinomas and Melanomas are with Hamed and Andy

Uber for Dog-Walkers Tobi Skovron has created an App that will summon a vetted dog-walker. He touts his high-end service as the next step in the evolution of pet-based technology. Protecting Your Pet From The Sun Our pets are at a higher risk than we are for sun-related Melanomas. You need to protect them from the sun, even if they're indoor animals. Dogfather Joey Villani and Dr. Debbie share what you need to know for your pet's safety and well being. 10-Year-Old Hero This week's Hero Person will charm you! She's just a little girl. But she has a huge heart for the animals. Samantha Frenck created a 501c3 non-profit that brings toys and blankets, among other things, to shelter animals. Pet Friendly Cities Forbes went in search of America's most pet-friendly places to live. The criteria included having the best landlords, lowest pet fees and most pet specialty stores and services. You might be surprised which city topped the list. Pet Store Switch What happens when you switch the pets in a pet store for animals from a shelter? Would the customers notice? A pet store in Brazil partnered with local pet shelters to secretly switch those pricey purebreds for rescues. Then the store went a step further and simply gave the shelter pets away to worthy families. …and of course, the Dream Team is answering your pet-related questions toll-free at 1-866-405-8405. More this week

This podcast partitions patients with early melanoma into those with very favorable features and compares them to those with a higher risk for dying of metastatic melanoma.

Guest: Bertil Damato,  FRCS, FRCOphthProfessor of OphthalmologyRoyal Liverpool University HospitalLiverpool, UK

Eleven uveal melanomas were analyzed using comparative genomic hybridization (CGH). The most abundant genetic changes were loss of chromosome 3, overrepresentation of 6p, loss of 6q, and multiplication of 8q. The smallest overrepresented regions on 6p and 8q were 6pterp21 and 8q24qter, respectively. Several additional gains and losses of chromosome segments were repeatedly observed, the most frequent one being loss of 9p (three cases). Monosomy 3 appeared to be a marker for ciliary body involvement. CGH data were compared with the results of chromosome banding. Some alterations, e.g., gains of 6p and losses of 6q, were observed with higher frequencies after CGH, while others, e.g., 9p deletions, were detected only by CGH. The data suggest some similarities of cytogenetic alterations between cutaneous and uveal melanoma. In particular, the 9p deletions are of interest due to recent reports about the location of a putative tumor-suppressor gene for cutaneous malignant melanoma in this region.