Clinical Gastroenterology & Hepatology

Withdrawal of Immunomodulators After Co-treatment Does Not Reduce Trough Level of Infliximab in Crohn's Disease Patients

Play Episode Listen Later Apr 2, 2015 14:19

A study in the March 2015 issue of CGH finds that withdrawal of immunomodulators after at least 6 months of co-treatment with infliximab does not reduce the trough levels of infliximab in patients with Crohn's disease.

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Development of Fecal Microbiota Transplantation

Play Episode Listen Later Apr 2, 2015 17:36

An article in the February issue of CGH looks at solutions to issues concerning fecal microbiota transplantation, and challenges involving this increasingly common procedure that still remain. Dr. Kuemmerle speaks with author Dr. Alexander Khoruts.

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Gastrointestinal Bleeding After Implantation of Ventricular Assist Devices

Play Episode Listen Later Feb 13, 2015 14:36

An article in the January issue of CGH investigated the incidence, etiology, and outcome of GI bleeding in patients with ventricular assist devices. Dr. Kuemmerle speaks to co-author Dr. John Vargo of the Cleveland Clinic.

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Mesalamine Dosage and Fecal Calprotectin in Patients With Quiescent Ulcerative Colitis

Play Episode Listen Later Nov 26, 2014 15:20

A study in the November issue of CGH investigated whether increasing doses of mesalamine reduces concentrations of fecal calprotectin in patients with quiescent ulcerative colitis. Dr. Kuemmerle speaks to author Dr. James D. Lewis.

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How Gastroenterologists Can Demonstrate Value

Play Episode Listen Later Oct 15, 2014 19:24

An AGA Board Strategic Update article in the October issue of CGH discusses recent changes to how a gastroenterologist demonstrates value in the era of the Affordable Care Act. Dr. Kuemmerle speaks to Dr. Lawrence Kosinski.

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Restarting Infliximab in IBD Patients with Prior Loss of Response

Play Episode Listen Later Sep 8, 2014 17:32

An article and accompanying editorial in the September issue of CGH discuss reinitiating infliximab therapy for inflammatory bowel disease patients after a period of discontinuation. Dr. Kuemmerle speaks w/ editorial co-author Dr. Maria T. Abreu.

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Evolution of Hepatitis C Virus Treatment

Play Episode Listen Later Aug 4, 2014 16:36

An editorial in the August issue of CGH discusses changing treatment methods for Hepatitis C Virus infection over the last several years. Dr. Kuemmerle speaks to first author Dr. Fasiha Kanwal of Baylor College of Medicine.

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Management of Dyslipidemia as a Cardiovascular Risk Factor in NAFLD Patients

Play Episode Listen Later Jul 2, 2014 11:03

An article in the July issue of CGH looks at management of dyslipidemia as a cardiovascular risk factor in patients with nonalcoholic fatty liver disease (NAFLD). Dr. Kuemmerle speaks to Dr. Kathleen Corey

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PPIs and NSAID–Related Lower Gastrointestinal Adverse Events

Play Episode Listen Later Jun 11, 2014 13:44

A commentary in the June issue of CGH looks at the effect of proton pump inhibitors (PPIs) and nonsteroidal anti-inflammatory drugs (NSAIDs) on the lower gastrointestinal tract. Dr. Kuemmerle speaks to author Dr. Francis KL Chan.

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History, Genetics, and Strategies for Cancer Prevention in Lynch Syndrome

Play Episode Listen Later May 1, 2014 17:34

A review article in the May issue of CGH looks at the major advances in risk assessment, molecular genetics, DNA mutational analyses, and cancer prevention and management of Lynch syndrome over the last 100 years; with guest Dr. Fay Kastrinos

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Prevalence of Eosinophilic Esophagitis in the U.S.

Play Episode Listen Later Apr 2, 2014 15:45

Eosinophilic esophagitis (EoE) has become a major cause of upper gastrointestinal morbidity in children and adults. A study in the April issue of CGH estimates the prevalence of EoE in the United States. Dr. Kuemmerle speaks to author Dr. Evan S. Dellon

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DNA Testing and Molecular Screening for Colon Cancer

Play Episode Listen Later Mar 21, 2014 24:48

An “Advances in Translational Science” article in the March issue of CGH looks at the future of DNA testing and molecular screening for colon cancer. Dr. Kuemmerle speaks with author Dr. John M. Carethers of the University of Michigan Dept of Medicine

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New Anticoagulant and Antiplatelet Agents

Play Episode Listen Later Feb 4, 2014 24:02

An article in the February issue of CGH offers a primer for gastroenterologists on the use of new anticoagulant and antiplatelet agents. Dr. Kuemmerle speaks with author Dr. Geoffrey M. Forbes

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A Study of Allogeneic Mesenchymal Stromal Cells for Luminal Crohn's Disease Refractory to Biologic Therapy

Play Episode Listen Later Jan 13, 2014 17:23

A phase 2 study in the January 2014 issue of CGH investigated the efficacy of allogeneic mesenchymal stromal cells in patients with luminal Crohn's disease. Dr. Kuemmerle speaks with author Dr. Geoffrey M. Forbes

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Reconsidering Diverticular Disease

Play Episode Listen Later Dec 3, 2013 11:43

A study in the December CGH finds that constipation and a low-fiber diet are not associated with diverticulosis. A related "Perspectives in Clinical Gastroenterology and Hepatology" article reconsiders conventional wisdom about diverticular disease.

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Interpretation and Management of Hepatic Abnormalities in Pregnancy

Play Episode Listen Later Nov 5, 2013 16:36

A review in the November issue of CGH provides a practical guide to evaluation and management of pregnant patients with abnormal liver chemistries or function. Dr. Kuemmerle speaks to Dr. Mary E. Rinella

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Bile Acid Malabsorption in the Colon

Play Episode Listen Later Oct 3, 2013 16:25

Two related articles appear in the October issue of CGH: "Methods for Diagnosis of Bile Acid Malabsorption in Clinical Practice” and “Bowel Functions, Fecal Unconjugated Primary and Secondary Bile Acids, and Colonic Transit in Patients With IBS.”

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Coagulation in Liver Disease: A Guide for the Clinician

Play Episode Listen Later Sep 7, 2013 25:03

An article in the September issue of CGH summarizes the pathophysiology of hemostasis in liver disease, describes pros and cons of lab tests for those patients, and outlines the optimal management of hemostasis for various clinical scenarios.

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Internet Liability for Gastroenterologists

Play Episode Listen Later Aug 1, 2013 20:48

An article in the August CGH discusses the dangers and advantages physicians should consider when utilizing the internet and social media in their medical practices or private communications. Dr. Kuemmerle speaks to Dr. Andrew D. Feld.

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Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Nonalcoholic Fatty Liver Patients

Play Episode Listen Later Jul 5, 2013 16:45

A study in the July issue of CGH compares the colonic microbiome and volatile organic compound metabolome of obese nonalcoholic fatty liver disease patients with that of healthy-weight individuals. Dr. Kuemmerle speaks to author Dr. Kevin P. Rioux.

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Cost-Effective Treatment for Crohn's Disease Patients Who Lose Responsiveness to Infliximab

Play Episode Listen Later Jun 4, 2013 16:09

A study in the June issue of CGH looks at whether a test-based or empiric dose-escalation strategy is more cost-effective for treating Crohn's disease patients who have stopped responding to Infliximab. Dr. Kuemmerle speaks to Dr. Fernando S. Velayos.

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Side Effects and Complications of Long-Term PPI Use or Fundoplication for GERD Treatment

Play Episode Listen Later May 3, 2013 24:43

Two articles in the May issue of CGH look examine side effects and complications of long-term proton pump inhibitor use, and fundoplication for GERD treatment. Dr. Kuemmerle discusses the pros and cons of each approach with the authors of these articles.

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Reassessing the Risks and Benefits of Thiopurines in Crohn's Disease

Play Episode Listen Later Apr 4, 2013 19:43

An editorial in the April issue of CGH takes a new look at the risks and benefits of thiopurines in treating Crohn's disease. Dr. Kuemmerle speaks to Dr. Stephen B. Hanauer of the University of Chicago Medical Center

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Placental Transfer of Anti–Tumor Necrosis Factor Agents in Pregnant Patients with Inflammatory Bowel Disease

Play Episode Listen Later Mar 1, 2013 14:39

A study in the March issue of CGH evaluated 31 pregnant women with IBD who receive Anti-TNF agents to determine transfer rates of the drugs to the fetus via the placenta. Dr. Kuemmerle speaks to Dr. Uma Mahadevan.

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Variation of Adenoma Prevalence by Age, Sex, Race, and Colon Location in a Large Population

Play Episode Listen Later Feb 1, 2013 14:35

A study in the February issue of CGH evaluated the prevalence of adenomas detected by sex, age, race/ethnicity, and colon location in a large population. Implications of these findings for screening and quality programs are discussed.

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Promises, Delivery, and Challenges of Inflammatory Bowel Disease Risk Gene Discovery

Play Episode Listen Later Jan 4, 2013 15:46

An “Advances in Translational Science” article in the February issue of CGH looks at promises, delivery, and challenges of IBD risk gene discovery. Dr. Kuemmerle speaks with Dr. Steven Brant

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Unfolding the Plot of Obscure Gastrointestinal Bleeding

Play Episode Listen Later Dec 4, 2012 14:28

Two studies in the December issue of CGH report potentital positive findings in treatment of obscure gastrointestinal bleeding. Dr. Kuemmerle speaks to the author of an accompanying editorial, Dr. Shajan Peter.

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How a Practice Chooses an Electronic Health Record

Play Episode Listen Later Nov 2, 2012 20:52

An article in the November issue of CGH provides guidance to GI practitioners who are transitioning to electronic health records. Dr. Kuemmerle speaks to author Dr. Michael L. Weinstein.

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Diagnosis and Management of Eosinophilic Esophagitis

Play Episode Listen Later Sep 28, 2012 25:42

An article in the October issue of CGH reviews the latest approach to diagnosis of eosinophilic esophagitis (EoE) and presents consensus diagnostic guidelines. Dr. Kuemmerle speaks to author Dr. Evan S. Dellon.

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A Gastroenterologist's Guide to Probiotics

Play Episode Listen Later Aug 30, 2012 15:19

A “Perspectives in Clinical Gastroenterology and Hepatology” article in the September issue of CGH provides condition-specific rationale for using probiotic therapy and literature-based recommendations. Dr. Kuemmerle speaks to author Dr. Matthew A. Ciorba

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Alanine Aminotransferase Confounds Use of Transient Elastography to Diagnose Fibrosis in Patients with Chronic Hepatitis C Virus Infection

Play Episode Listen Later Aug 1, 2012 17:36

In patients with hepatitis c virus infection and early-stage fibrosis, increased levels of alanine aminotransferase was found to correlate with liver stiffness among patients in the lowest strata of fibrosis. Dr. Kuemmerle speaks with Dr. Nezam Afdhal.

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Practice Management: The Road Ahead

Play Episode Listen Later Jun 27, 2012 27:05

As CGH welcomes a new Board of Editors in the July 2012 issue, Dr. Kuemmerle speaks to Dr. John I. Allen, new section editor of Practice Management: The Road Ahead, in a special, wide-ranging interview about the future of GI practice.

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Risk of Colorectal Cancer in Patients with Ulcerative Colitis

Play Episode Listen Later Jun 1, 2012 13:57

A meta-analysis of population-based cohort studies to determine the risk of colorectal cancer in patients with ulcerative colitis appears in the June issue of CGH. Dr. Kuemmerle speaks to author Dr. Tine Jess.

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Telbivudine Prevents Vertical Transmission From HBeAg-Positive Women With Chronic Hepatitis B

Play Episode Listen Later Apr 24, 2012 14:01

Telbivudine reduces hepatitis B virus (HBV) DNA and normalizes levels of alanine aminotransferase (ALT) in patients with chronic hepatitis B (CHB). A study in the May issue of CGH by Dr. Calvin Pan investigates its use in preventing vertical transmission.

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Determinants of Serum Alpha-Fetoprotein Levels in Hepatitis C–Infected Patients

Play Episode Listen Later Mar 27, 2012 16:33

A study in the April issue of CGH examines determinants of serum alpha fetoprotein (AFP) levels in hepatitis C–infected patients. Dr. Kuemmerle speaks to author Dr. Hashem B. El-Serag.

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Colorectal Neoplasia Risk in Patients with Colonic Crohn's Disease and Concomitant Primary Sclerosing Cholangitis

Play Episode Listen Later Mar 1, 2012 12:10

A study in the March issue of CGH looks at whether primary sclerosing cholangitis is also a risk factor for colorectal dysplasia or cancer in patients with Crohn's disease of the colon. Dr. Kuemmerle speaks with senior author Dr. Roger Chapman

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Current Options for Ambulatory Surgery Centers

Play Episode Listen Later Feb 21, 2012 14:31

A Practice Management article in the January 2012 issue of CGH outlines three major options for owners of ambulatory surgery centers (ASCs) to deal with decreased reimbursements and rising costs. Dr. Kuemmerle speaks with author Dr. Lawrence R. Kosinski

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Adverse Events Do Not Outweigh Benefits of Combination Therapy for Crohn's Disease in a Decision Analytic Model

Play Episode Listen Later Dec 22, 2011 19:31

Adverse Events Do Not Outweigh Benefits of Combination Therapy for Crohn's Disease in a Decision Analytic Model. Dr. Kuemmerle speaks to the first author of this study in the January issue of CGH, Dr. Corey Siegel.

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Use of Fecal Microbiota Transplantation to Treat Clostridium difficile Infection

Play Episode Listen Later Dec 1, 2011 15:45

A “Perspective” article in the December issue of CGH looks at the rationale, methods, and use of fecal microbiota transplantation as treatment for Clostridium difficile infection. Dr. Kuemmerle speaks to co-author Dr. Christina Surawicz.

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Using Transjugular Intrahepatic Portosystemic Shunts (TIPS) for Complications of Cirrhosis

Play Episode Listen Later Nov 1, 2011 18:15

A look at new information in the November issue of CGH concerning Transjugular Intrahepatic Portosystemic Shunts (TIPS) for complications of cirrhosis. Dr. Kuemmerle speaks to Dr. Arun Sanyal of Virginia Commonwealth University

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Factors That Predict Relief from Upper Abdominal Pain After Cholecystectomy

Play Episode Listen Later Oct 1, 2011 20:11

Upper abdominal pain in patients with gallstones is often treated by cholecystectomy but frequently persists. A study in the October issue of CGH found factors that determine patients' odds for relief. Dr. Kummerle speaks to author Dr. Johnson L. Thistle

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Immune Dysfunction and Infections in Patients with Cirrhosis

Play Episode Listen Later Sep 1, 2011 16:59

A review article in the September issue of CGH looks at the pathogenesis of infections and immune dysfunction in patients with cirrhosis. Dr. Kuemmerle speaks to author K. Rajender Reddy of the University of Pennsylvania Health System

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Early Fluid Resuscitation in Acute Pancreatitis: Strategies and Reduced Morbidity

Play Episode Listen Later Aug 2, 2011 12:23

Early Fluid Resuscitation Reduces Morbidity Among Patients With Acute Pancreatitis; Lactated Ringer's Solution Reduces Systemic Inflammation Compared With Saline in Patients With Acute Pancreatitis. Dr. Kuemmerle interviews author Dr. Timothy B. Gardner

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Prevalence of Primary Biliary Cirrhosis–Autoimmune Hepatitis Overlap Syndrome

Play Episode Listen Later Jul 6, 2011 13:29

A study in the July CGH looked to diagnose the primary biliary cirrhosis (PBC)–chronic autoimmune hepatitis (AIH) overlap syndrome and their level of overlap at a tertiary referral center. Dr. Kuemmerle speaks with Dr. Marshall M. Kaplan.

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Treatment of Ulcerative Colitis to Achieve Mucosal Healing

Play Episode Listen Later Jun 3, 2011 17:13

Mucosal healing predicts late outcomes after the first course of corticosteroids for newly diagnosed ulcerative colitis, according to a study in the June CGH. Dr. Kuemmerle speaks to the author of an accompanying editorial, Dr. David T. Rubin

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Symptoms May Not Indicate Failure of Anti–Tumor Necrosis Factor Therapy in Crohn's Disease

Play Episode Listen Later May 6, 2011 21:17

A Perspective article in the May issue of CGH examines the challenges of monitoring patients with Crohn's disease who remain symptomatic despite anti–tumor necrosis factor therapy. Dr. Kuemmerle speaks to author Dr. William Sandborn

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Noncardiac Chest Pain: Evaluation and Treatment

Play Episode Listen Later Apr 5, 2011 18:34

An “Education Practice” article in the April issue of CGH looks at a clinical scenario involving evaluation and treatment of noncardiac chest pain. Dr. Kuemmerle speaks with author Dr. David Katzka.

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Renal Dysfunction as a Predictor of Mortality in Cirrhotic Patients with Spontaneous Bacterial Peritonitis

Play Episode Listen Later Mar 18, 2011 14:26

A study in the March issue of CGH identifies renal dysfunction as the primary independent predictor of mortality in cirrhotic patients with spontaneous bacterial peritonitis (SBP). Dr. Kuemmerle speaks to study author Dr. Guadalupe Garcia–Tsao

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Diminutive Polyps Found During Colonoscopy: How Should They Be Evaluated and Removed?

Play Episode Listen Later Feb 18, 2011 16:48

An Education Practice article in the February issue of CGH looks at a clinical scenario involving evaluation and removal of diminutive polyps found during colonoscopy

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Liver Biopsy Rarely Needed for Diagnosing Typical Laboratory Features of Autoimmune Hepatitis

Play Episode Listen Later Jan 20, 2011 12:27

A study in the December issue of CGH sought to clarify the importance of histologic analysis of biopsy samples in the diagnosis and management of patients with autoimmune hepatitis (AIH). Dr. Kuemmerle speaks to study co-author Dr. Keith Lindor

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Liver Disease in HIV-Infected Individuals

Play Episode Listen Later Dec 1, 2010 18:56

A review in the December issue of CGH examines the causes of liver disease among the HIV-infected population in the era of antiretroviral therapy (ART). Dr. Kuemmerle speaks to author Dr. Jennifer Price.

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