Podcasts about Metabolome

Metabolome – an intermediary linking the environmental exposures and life-course health. The metabolome refers to the complete set of small-molecule chemicals found within in organisms including cells, tissues, and biofluids. Luennon tekstivastine: https://www.utu.fi/fi/yliopisto/akateemiset-juhlat/professoriluennot/marraskuu-2024/matej-oresic

Guerra, DJ. 2024. lecture notes Leach, Donovan. 1967 "Mountain Jam" Allman Brothers https://youtu.be/w9ZubobGMLs?si=uHLon1CvCiCSiqtX --- Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Metabolism plays an important role in our day to day lives. Our metabolism changes over time as we age, with conditions such as osteoarthritis and in people who are above a healthy weight. The study of the small molecules chemicals in biological samples or the study of metabolomics is an emerging field in research. On this week's episode of Joint Action, we are joined by Ron June and Hope Welhaven to discuss the role of the metabolome in osteoarthritis. Dr Ron June is a Professor and bioengineer based at Montana State University, USA. His research interests include osteoarthritis and biomechanics. He also recently founded a company, OpenBioWorks, seeking to provide commercial metabolomic profiling services.Dr Hope Welhaven's research focusses on investigating the metabolism of musculoskeletal tissues during times of health and disease, such as osteoarthritis. She uses mass spectrometry-based techniques including metabolomics and imaging to identify and examine metabolic mechanisms involved in disease progression. RESOURCESJournal articles· The metabolome of individuals with knee osteoarthritis is influenced by 18-months of an exercise and weight loss intervention and sex: the IDEA trialCONNECT WITH USTwitter/X: @ProfDavidHunter @jointactionorgInstagram: @ProfDavidHunterEmail: hello@jointaction.info Hosted on Acast. See acast.com/privacy for more information.

They're some of the healthiest foods available, so why do vegetables cause bloating for many people? I'll break down what causes our stomach to bloat and suggest effective, researched-backed solutions. Tune-in! If you have any questions or topics you would like covered in the future, let me know in the comments!   Watch/Read Next… How to Heal Your Gut with the Low FODMAP Diet: https://drruscio.com/low-fodmap/ A Step-By-Step Guide to the Low FODMAP Diet: https://drruscio.com/low-fodmap-diet/ Standard Low FODMAP Downloadable Guide: https://drruscio.com/wp-content/uploads/2020/02/5bStandard-Low-FODMAP-Diet-2020-5.pdf Vegetarian Low FODMAP Downloadable Guide: https://drive.google.com/file/d/1r_O3SicImc7RFdgqvLiueTUcr_HgYoyL/view Monash App: https://www.monash.edu/monash-innovation/news/success-stories/fodmap How to Use Probiotics for Leaky Gut: https://drruscio.com/probiotics-for-leaky-gut/ How to Relieve Bloating: https://drruscio.com/how-to-relieve-bloating/ How to Balance Hormones: https://drruscio.com/how-to-balance-hormones/   Timestamps 00:00 Intro  00:22 Why veggie bloat happens 03:58 Bloating and FODMAPS 05:03 Overgrowths and dysbiosis 06:55 Inflammation and leaky gut 08:14 Histamine intolerance  10:22 Serotonin and female hormones  11:30 The efficacy of the low FODMAP diet 14:07 How to rehab the gut   Featured Studies  Management of Chronic Abdominal Distension and Bloating: https://pubmed.ncbi.nlm.nih.gov/32246999/   Abdominal Bloating in the United States: https://pubmed.ncbi.nlm.nih.gov/36396061/ U.S. Householder Survey of Functional Gastrointestinal Disorders: https://pubmed.ncbi.nlm.nih.gov/8359066/ Prevalence and Associated Factors of Bloating: https://pubmed.ncbi.nlm.nih.gov/37315866/ Evaluation Of Carbohydrate and Fiber Consumption: https://pubmed.ncbi.nlm.nih.gov/31141064/ Short Chain Carbohydrates Alters the Pattern of Gas Production and Genesis: https://pubmed.ncbi.nlm.nih.gov/20659225/ Influence of Low FODMAP-Gluten Free Diet: https://pubmed.ncbi.nlm.nih.gov/34261437/ Impact of Saccharomyces Boulardii on Bacterial Overgrowth: https://pubmed.ncbi.nlm.nih.gov/36630947/ Symptoms of Patients with IBS Undergoing a Low-FODMAP Diet: https://pubmed.ncbi.nlm.nih.gov/34371976/ FODMAPs Alter Symptoms and the Metabolome of Patients with IBS: https://pubmed.ncbi.nlm.nih.gov/26976734/ High FODMAP Diet Causes Barrier Loss: https://pubmed.ncbi.nlm.nih.gov/34618688/ Effect of Diet on Gastrointestinal Endocrine Cells in IBS Patients: https://pubmed.ncbi.nlm.nih.gov/28849091/ Efficacy of a Low FODMAP Diet in IBS: https://pubmed.ncbi.nlm.nih.gov/34376515/ Challenges of the Low FODMAP Diet For Managing IBS: https://pubmed.ncbi.nlm.nih.gov/32468985/ Gut Symptoms during FODMAP Restriction and Food Challenges during FODMAP Reintroduction: https://pubmed.ncbi.nlm.nih.gov/37375587/ Effects of Probiotics Administration on Lactose Intolerance in Adulthood: https://pubmed.ncbi.nlm.nih.gov/37225575/ The Effect of a Short-Term Physical Activity  on Abdominal Bloating: https://pubmed.ncbi.nlm.nih.gov/33868611/ Get the Latest Updates Facebook - https://www.facebook.com/DrRusciodc Instagram - https://www.instagram.com/drrusciodc/ Pinterest - https://www.pinterest.com/drmichaelrusciodc    DISCLAIMER: The information on this site is not intended or implied to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified healthcare provider before starting any new treatment or discontinuing an existing treatment. Music featured in this video: "Modern Technology" by Andrew G, https://audiojungle.net/user/andrew_g  *Full transcript available on YouTube by clicking the “Show transcript” button on the bottom right of the video.

References Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids2014.Volume 1841, Issue 9, Pages 1241-1246 Guerra-graduate lipid lectures --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Today in Episode 153, I share with you a recent study published by Amin and colleagues in JAMA Psychiatry this year. This study includes over 125,000 people to correlate the plasma metabolome containing 249 metabolites to the diagnosis of major depressive disorder. I share additional clinical trials to take these findings and give us all some actionable information. Tune in for details!Main Reference: Amin et al. JAMA Psychiatry. 2023;80(6):597-609Want to buy me a coffee to say thanks for the episode? You can do so via Venmo or Patreon below.Venmo ID: Steph-CalPatreon: https://www.patreon.com/join/DrSCaligiurihttps://www.buymeacoffee.com/drscaligiuriFollow me on social media to see the papers I cite in this week's episode:IG: Dr.SCaligiuriFB: ThePeoplesScientistTwitter: DrSCaligiuriLinkedin: Stephanie CaligiuriTikTok: Dr.SCaligiuri Hosted on Acast. See acast.com/privacy for more information.

Lege Sjur Even Aunmo er opptatt av å følge med på forskning. I denne episoden forteller han om problemene med å leve av planter. Planter har nemlig forsvarsmekanismer mot å bli spist. De kan dessuten stjele mineraler, trigge immunsystemet, tilføre tungmetall og gi næring til kreft. Selv foretrekker han et kosthold bestående utelukkende av animalske produkter. Han synes det er beklagelig at rådene har blitt politiske gjennom at de har tatt inn klimasaken, fremfor at de er en mest mulig sann fremstilling av hva ulike typer mat gjør med kroppen. Aunmo legger frem forskningsevidens som peker i motsatt retning av kostholdsrådene norske myndigheter har lagt frem nylig. Han har mange suksesshistorier fra pasienter med autoimmune sykdommer, diabetes og andre sykdommer, som har blitt friske etter at de sluttet å spise bestemte typer planter, produkter fra planter eller utelukket dem helt fra kosten.Sjur Even Aunmo: • youtube.com • facebook.comGrønnsaker uten noen kjent form for gluten: • hodekål, blomkål, brokkoli, paprika, rødbeter, bladbete, squash, potet, søtpotet, gulrøtter, gresskar, romano-salat, indisk bladsennep, spinat, grønnkål • Obs: Selv om disse plantene ikke inneholder gluten, finnes det andre stoffer i dem som er uheldige. Paprika, for eksempel, hører til søtvier-familien, sammen med potet og tobakk. De forsvarer seg mot mennesker, dyr og insekter med lektiner og solanin. Spinat inneholder mye oksalat som stjeler kalsium fra kroppen. Det finnes igjen i nyrestener og mistenkes for å stimulere brystkreft. Grønnsaker inneholder druesukker, som er et viktig næringsstoff for kreft. Grønnsaker som vokser over bakken inneholder ofte mindre sukker enn de som vokser under bakken. De minst usunne grønnsakene på listen synes å være hodekål, blomkål og brokkoli, på tross av at disse danner goitrin, et stoff som motvirker dannelsen av stoffskiftehormon.Diverse kilder: • Mindre kjøtt, mer plantebasert: Her kommer De nordiske ernæringsanbefalingene 2023 • Helsedirektoratets kostråd • The Seven Countries Study (søk) • Paleo diet (søk) • Keto diet (søk) • Carnivore diet (søk)› Relaterte AJP-episoder: • AJP 61 | Sjur Even Aunmo – Fikk sparken for å snakke om bivirkningerRelatert forskning:› FETT› https://doi.org/10.1136/bmj.e8707 Use of dietary linoleic acid for secondary prevention of coronary heart disease and death: evaluation of recovered data from the Sydney Diet Heart Study and updated meta-analysis› https://doi.org/10.1136/bmj.i1246 Re-evaluation of the traditional diet-heart hypothesis: analysis of recovered data from Minnesota Coronary Experiment (1968-73)› https://doi.org/10.3945/ajcn.2009.27725 Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease› https://doi.org/10.1186/s12937-017-0254-5 The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials› https://doi.org/10.1016/j.jacc.2020.05.077 Saturated Fats and Health: A Reassessment and Proposal for Food-Based Recommendations: JACC State-of-the-Art Review› http://dx.doi.org/10.1136/openhrt-2014-000196 Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis› http://dx.doi.org/10.1136/bmjebm-2019-111180 Fat or fiction: the diet-heart hypothesis› https://www.mn.uio.no/ibv/tjenester/kunnskap/plantefys/leksikon/h/herdet-fett.html› https://doi.org/10.1046/j.1471-4159.1997.68052092.x 4-Hydroxynonenal-Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease› https://doi.org/10.1016/j.freeradbiomed.2006.07.021 Induction of mitochondrial nitrative damage and cardiac dysfunction by chronic provision of dietary ω-6 polyunsaturated fatty acids› https://doi.org/10.1038/s41467-018-05614-6 Dietary stearic acid regulates mitochondria in vivo in humans› http://dx.doi.org/10.17140/AFTNSOJ-1-123 Oxidation of Polyunsaturated Fatty Acids and its Impact on Food Quality and Human Health› https://doi.org/10.1194/jlr.M026179 Dietary oxidized n-3 PUFA induce oxidative stress and inflammation: role of intestinal absorption of 4-HHE and reactivity in intestinal cells› https://doi.org/10.1021/jf049207s Effect of the Type of Frying Culinary Fat on Volatile Compounds Isolated in Fried Pork Loin Chops by Using SPME-GC-MS› STATINER (KOLESTEROLSENKENDE STOFFER)› http://dx.doi.org/10.1136/bmjopen-2018-023085 Statins for the primary prevention of cardiovascular disease: an overview of systematic reviews› http://dx.doi.org/10.1136/bmjopen-2014-007118 The effect of statins on average survival in randomised trials, an analysis of end point postponement› https://doi.org/10.1001/archinternmed.2010.182 Statins and All-Cause Mortality in High-Risk Primary Prevention: A Meta-analysis of 11 Randomized Controlled Trials Involving 65 229 Participants› https://www.felleskatalogen.no/medisin/lipitor-upjohn-eesv-pfizer-560999› https://www.felleskatalogen.no/medisin/zocor-organon-565655› https://www.legemiddelhandboka.no/L8.15.1/Statiner› https://www.bmj.com/campaign/statins-open-data Statins - a call for transparent data› https://doi.org/10.1001/archinternmed.2011.625 Statin Use and Risk of Diabetes Mellitus in Postmenopausal Women in the Women's Health Initiative› https://doi.org/10.1007/s40264-017-0620-4 Amyotrophic Lateral Sclerosis Associated with Statin Use: A Disproportionality Analysis of the FDA's Adverse Event Reporting System› https://doi.org/10.1001/jamainternmed.2020.6084 Evaluation of Time to Benefit of Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years› https://doi.org/10.1016/j.atherosclerosis.2022.07.003 Statin therapy for the primary prevention of cardiovascular disease: Cons› http://doi.org/10.1161/STROKEAHA.121.034576 Lipid-Lowering Therapy and Hemorrhagic Stroke RiskLipid-Lowering Therapy and Hemorrhagic Stroke Risk› KJØTT› https://www.acpjournals.org/doi/full/10.7326/M19-0622 Effect of Lower Versus Higher Red Meat Intake on Cardiometabolic and Cancer Outcomes A Systematic Review of Randomized Trials› https://doi.org/10.3945/ajcn.116.142521 Total red meat intake of ≥0.5 servings/d does not negatively influence cardiovascular disease risk factors: a systemically searched meta-analysis of randomized controlled trials› https://doi.org/10.3945/ajcn.113.062638 Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studies› FISK› https://doi.org/10.1093/jn/nxab112 Biomarkers and Fatty Fish Intake: A Randomized Controlled Trial in Norwegian Preschool Children› https://doi.org/10.1007/s12016-013-8363-1 Fish Allergy: In Review› KOLESTEROL› http://dx.doi.org/10.1136/bmjopen-2015-010401 Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review› https://doi.org/10.1016/j.mehy.2018.09.019 Inborn coagulation factors are more important cardiovascular risk factors than high LDL-cholesterol in familial hypercholesterolemia› PMID: 18277343 ApoB/ApoA1 ratio and subclinical atherosclerosis› https://doi.org/10.1016/0021-9150(89)90130-5 Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages› https://doi.org/10.1161/01.CIR.93.7.1346 Cigarette Smoking Potentiates Endothelial Dysfunction of Forearm Resistance Vessels in Patients With Hypercholesterolemia: Role of Oxidized LDL› https://doi.org/10.1161/01.CIR.97.20.2012 Passive Smoking Induces Atherogenic Changes in Low-Density Lipoprotein› https://doi.org/10.1016/j.atherosclerosis.2008.04.046 Smoking and smoking cessation—The relationship between cardiovascular disease and lipoprotein metabolism: A review› https://doi.org/10.1161/ATVBAHA.113.300156 Smoking and Cardiovascular Disease› https://doi.org/10.3402/fnr.v59.29240 LDL biochemical modifications: a link between atherosclerosis and aging› https://doi.org/10.1016/j.cjca.2017.07.015 Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies› https://doi.org/10.1054/plef.2000.0204 Why is glycated LDL more sensitive to oxidation than native LDL? A comparative study.› KARBOHYDRAT› https://www.helsedirektoratet.no/rapporter/anbefalinger-om-kosthold-ernaering-og-fysisk-aktivitet/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf/_/attachment/inline/2f5d80b2-e0f7-4071-a2e5-3b080f99d37d:2aed64b5b986acd14764b3aa7fba3f3c48547d2d/Anbefalinger%20om%20kosthold%20ern%C3%A6ring%20og%20fysisk%20aktivitet.pdf› FRUKTOSE› https://doi.org/10.1016/j.jhep.2021.02.027 Fructose- and sucrose- but not glucose-sweetened beverages promote hepatic de novo lipogenesis: A randomized controlled trial› https://doi.org/10.1093/ajcn/nqaa332 Effects of fructose restriction on liver steatosis (FRUITLESS); a double-blind randomized controlled trial› https://doi.org/10.5223/pghn.2021.24.5.483 The Relationship between Daily Fructose Consumption and Oxidized Low-Density Lipoprotein and Low-Density Lipoprotein Particle Size in Children with Obesity› KUNSTIG SØTNING› https://doi.org/10.1016/s0378-8741(99)00081-1 Effects of chronic administration of Stevia rebaudiana on fertility in rats› https://doi.org/10.1371/journal.pone.0000698 Intense Sweetness Surpasses Cocaine Reward› https://doi.org/10.1016/j.cell.2022.07.016 Personalized microbiome-driven effects of non-nutritive sweeteners on human glucose tolerance› https://doi.org/10.1289/ehp.8711 First Experimental Demonstration of the Multipotential Carcinogenic Effects of Aspartame Administered in the Feed to Sprague-Dawley Rats› https://doi.org/10.1289/ehp.10271 Life-Span Exposure to Low Doses of Aspartame Beginning during Prenatal Life Increases Cancer Effects in Rats› DIABETES› https://doi.org/10.1001/jama.295.6.655 Low-Fat Dietary Pattern and Risk of Cardiovascular DiseaseThe Women's Health Initiative Randomized Controlled Dietary Modification Trial – se side 661, økt hjerte/kar-risk sfa. Lavfett-diett› https://doi.org/10.3945/ajcn.110.010843 Effects of a low-fat dietary intervention on glucose, insulin, and insulin resistance in the Women's Health Initiative (WHI) Dietary Modification trial› https://doi.org/10.1007/s11745-008-3274-2 AOCS Lipids (lavranket journal) Carbohydrate Restriction has a More Favorable Impact on the Metabolic Syndrome than a Low Fat Diet› https://doi.org/10.1161/ATVBAHA.114.303284 Small Dense Low-Density Lipoprotein-Cholesterol Concentrations Predict Risk for Coronary Heart Disease- ArtThromVas prospektiv kohort› https://doi.org/10.1097/MOL.0b013e328306a057 Glycation as an atherogenic modification of LDL : Current Opinion in Lipidology› https://doi.org/10.1016/0021-9150(93)90084-8 Glycosylated low density lipoprotein is more sensitive to oxidation: implications for the diabetic patient?› https://doi.org/10.2337/diabetes.55.02.06.db05-1103 Loss of Endothelial Glycocalyx During Acute Hyperglycemia Coincides With Endothelial Dysfunction and Coagulation Activation In Vivo› https://doi.org/10.1016/S0895-7061(00)01260-7 Blood viscosity and blood pressure: role of temperature and hyperglycemia› https://doi.org/10.2337/dc13-1374 Blood Viscosity in Subjects With Normoglycemia and Prediabetes› https://doi.org/10.1007/s00592-017-1004-z Elevated 1-h post-challenge plasma glucose levels in subjects with normal glucose tolerance or impaired glucose tolerance are associated with whole blood viscosity› https://doi.org/10.1080/09674845.2010.11730293 Blood viscosity at different stages of diabetes pathogenesis.› DIABETES-DEMENS› https://doi.org/10.1212/WNL.53.9.1937 Diabetes mellitus and the risk of dementia - The Rotterdam Study› https://doi.org/10.1016/S1474-4422(05)70284-2 Lancet Neurology 2006, sysrew lavere evidensgrad. Risk of dementia in diabetes mellitus: a systematic review› https://doi.org/10.1111/j.1445-5994.2012.02758.x Diabetes as a risk factor for dementia and mild cognitive impairment: a meta-analysis of longitudinal studies› https://doi.org/10.1016/j.arr.2019.100944 Diabetes mellitus and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 144 prospective studies› https://doi.org/10.1177/193229680800200619 Alzheimer's Disease is Type 3 Diabetes—Evidence Reviewed› https://doi.org/10.3390/ijerph120708281 Evaluating the Association between Diabetes, Cognitive Decline and Dementia› https://doi.org/10.3390/ijms21030934 Ketone Bodies Promote Amyloid-β1–40 Clearance in a Human in Vitro Blood–Brain Barrier Model› https://doi.org/10.1038/s41574-018-0048-7 Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications› https://doi.org/10.1038/s41586-020-2247-3 APOE4 leads to blood–brain barrier dysfunction predicting cognitive decline› DIABETES NYRESYKDOM› https://doi.org/10.2337/diacare.27.2007.S79 Nephropathy-in-Diabetes Nephropathy in Diabetes› Diabetic Nephropathy: Diagnosis, Prevention, and Treatment› https://doi.org/10.1016/S0272-6386(96)90538-7 Diabetic nephropathy in type II diabetes› DIABETES ØYESYKDOM› https://doi.org/10.1016/S0140-6736(09)62124-3 Diabetic retinopathy› https://doi.org/10.1016/S2213-8587(18)30128-1 Incidence and progression of diabetic retinopathy: a systematic review› DIABETES HJERTE- OG KAR-SYKDOM› https://doi.org/10.1001/jamacardio.2020.7073 Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women› PLANTE-ANTINÆRINGSSTOFF, VERN OG GIFT› https://doi.org/10.1016/j.foodchem.2008.01.056 Food Chemistry 2008 Bioaccessibility of Ca, Mg, Mn and Cu from whole grain tea-biscuits: Impact of proteins, phytic acid and polyphenols› https://doi.org/10.1002/mnfr.200900099 Phytate in foods and significance for humans: food sources, intake, processing, bioavailability, protective role and analysis.› https://doi.org/10.1046/j.1440-6047.1999.00038.x Oxalate content of foods and its effect on humans› https://doi.org/10.1104/pp.109.2.347 Lectins as plant defense proteins.› https://doi.org/10.1016/j.taap.2009.03.012 Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction› https://doi.org/10.1038/s41531-018-0066-0 Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat› https://doi.org/10.1016/S0140-6736(05)79894-9 Identification of intact peanut lectin in peripheral venous blood› https://doi.org/10.1136/bmj.318.7190.1023 Do dietary lectins cause disease?› https://doi.org/10.1016/S0015-0282(16)54596-8 Lectin binding of endometrium in women with unexplained infertility› https://doi.org/10.1016/S0271-5317(88)80133-7 Changes in organs and tissues induced by feeding of purified kidney bean (Phaseolus vulgaris) lectins› https://doi.org/10.3390/molecules20022014 Insecticidal Activity of Plant Lectins and Potential Application in Crop Protection› https://doi.org/10.1210/endo-113-6-1921 Bound Lectins that Mimic Insulin Produce Persistent Insulin-Like Activities› https://doi.org/10.1042/BJ20071137 Contribution of leptin receptor N-linked glycans to leptin binding› https://doi.org/10.1111/j.1365-2249.2007.03368.x Potato lectin activates basophils and mast cells of atopic subjects by its interaction with core chitobiose of cell-bound non-specific immunoglobulin E› https://doi.org/10.1002/(SICI)1521-4141(199903)29:03 Dietary lectins can induce in vitro release of IL-4 and IL-13 from human basophils› https://doi.org/10.1016/j.ekir.2018.07.020 Secondary Oxalate Nephropathy: A Systematic Review› http://dx.doi.org/10.1136/gut.16.3.193 The effect of tea on iron absorption.› PMID: 1862 Disler PB, Lynch SR, Torrance JD, et al. The mechanism of the inhibition of iron absorption by tea. The South African Journal of Medical Sciences. 1975 ;40(4):109-116.› https://doi.org/10.1016/0887-2333(95)00113-1 Effects of saponins and glycoalkaloids on the permeability and viability of mammalian intestinal cells and on the integrity of tissue preparationsin vitro› https://doi.org/10.1079/BJN2002725 The biological action of saponins in animal systems: a review› http://doi.org/10.1093/carcin/bgp082 Lung tumor promotion by curcumin› https://doi.org/10.3945/ajcn.2009.26736M Cancer incidence in vegetarians: results from the European Prospective Investigation into Cancer and Nutrition (EPIC-Oxford)› https://doi.org/10.3382/ps.0550716 Antithyroid Activity of Goitrin in Chicks› https://doi.org/10.1016/s0278-6915(82)80294-9 Hepatic effects of R-goitrin in in Sprague-Dawley rats› https://doi.org/10.1002/ana.24448 Vagotomy and subsequent risk of Parkinson's disease --> https://doi.org/10.1038/s41531-018-0066-0› Ingestion of subthreshold doses of environmental toxins induces ascending Parkinsonism in the rat› http://doi.org/10.1056/NEJMra2010852 Salicylate Toxicity› https://doi.org/10.1021/jf0113070 Relationship between Cyanogenic Compounds in Kernels, Leaves, and Roots of Sweet and Bitter Kernelled Almonds› https://doi.org/10.1179/146532810X12637745451951Cyanide poisoning caused by ingestion of apricot seeds› https://doi.org/10.3390/toxins11060324 Ricin: An Ancient Story for a Timeless Plant Toxin› https://doi.org/10.1016/j.taap.2009.03.012Effects of wheat germ agglutinin on human gastrointestinal epithelium: Insights from an experimental model of immune/epithelial cell interaction› GLUTEN› https://doi.org/10.1080/00365520500235334 Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines› https://doi.org/10.1053/j.gastro.2008.03.023 Gliadin Induces an Increase in Intestinal Permeability and Zonulin Release by Binding to the Chemokine Receptor CXCR3› https://doi.org/10.1016/j.jprot.2017.03.026 A curated gluten protein sequence database to support development of proteomics methods for determination of gluten in gluten-free foods› https://doi.org/10.1111/jgh.13703 What is gluten?› https://doi.org/10.1186/s41043-015-0032-y The opioid effects of gluten exorphins: asymptomatic celiac disease› https://doi.org/10.1016/j.peptides.2015.07.013 Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects› SOYA› https://doi.org/10.1271/bbb.70516Soymorphins, novel μ opioid peptides derived from soy β-conglycinin β-subunit, have anxiolytic activities.› TILSETNINGSSTOFFER› https://doi.org/10.3233/NHA-170023 A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity› https://doi.org/10.1053/j.gastro.2021.11.006 Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome› https://doi.org/10.1002/ijc.21925 Processed meat consumption, dietary nitrosamines and stomach cancer risk in a cohort of Swedish women› KETOGENISITET/KREFT› https://oslo-universitetssykehus.no/behandlinger/pet-undersokelse› https://stanfordhealthcare.org/medical-tests/p/pet-scan/what-to-expect.html› https://www.sciencedirect.com/topics/medicine-and-dentistry/warburg-effect› https://doi.org/10.1016/j.tibs.2015.12.001 The Warburg Effect: How Does it Benefit Cancer Cells?› https://doi.org/10.1080/01635581.2019.1650942 Feasibility, Safety, and Beneficial Effects of MCT-Based Ketogenic Diet for Breast Cancer Treatment: A Randomized Controlled Trial Study› https://doi.org/10.1093/jnci/djs399 Dietary Glycemic Load and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings From CALGB 89803› https://doi.org/10.18632/aging.101382 Ketogenic diet in cancer therapy› IATROGENISITET› https://doi.org/10.1111/eci.12834 How to survive the medical misinformation mess› https://doi.org/10.1111/jlme.12068 Institutional Corruption of Pharmaceuticals and the Myth of Safe and Effective Drugs› https://doi.org/10.1136/bmj.f3830 Why we can't trust clinical guidelines› https://doi.org/10.1016/S0140-6736(15)60696-1 Offline: What is medicine's 5 sigma?› https://apjcn.nhri.org.tw/server/apjcn/procnutsoc/1990-1999/1995/1995%20p1-10.pdfLast ned episodenInnspilt: 2023-07-18Publisert: 2023-07-28Støtte Antijantepodden?Liker du arbeidet vi gjør, og vil bidra til at vi lager flere episoder?Finn ut hvordan du kan gi noe tilbake ved å gå til antijantepodden.com!Meld deg på vårt nyhetsbrev

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.07.26.550629v1?rss=1 Authors: Li, W., Tu, J., Zheng, J., Das, A., Yan, Q., Jiang, X., Ding, W., Bai, X., Lai, K., Yang, S., Yang, C., Zou, J., Diwan, A. D., Zheng, Z. Abstract: Chronic low back pain (LBP) is the leading cause of global disability. Vertebral bone marrow lesions (BMLs), one etiological factor for chronic LBP, are MRI signal changes in the vertebral bone marrow that extend from the disc endplate. The adipogenesis of bone marrow mesenchymal stem cells (BM-MSCs) could explain fatty replacement (FR) in normal bone marrow. FR is the most common type of BMLs. Here we show how the gut microbiome and serum metabolome change and how they interact in LBP patients with or without FR. The serum metabolome of chronic LBP patients with FR is characterized by decreased levels of branched-chain amino acids (BCAAs), which correlate with a gut microbiome that has important capability to regulate BCAA degradation pathway. Ruminococcus gnavus, Roseburia hominis and Lachnospiraceae bacterium 8 1 57FAA are identified as the main species driving the association between biosynthesis of BCAAs and BM-MSCs metabolism in LBP with FR individuals. In vitro work demonstrates that BCAAs can induce the adipogenesis of BM-MSCs by activating the SIRT4 pathway. Our findings provide a deep insight into understanding the role of the disturbed gut ecosystem in FR and LBP. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Dr. Thomas Metz, Ph.D. ( https://www.pnnl.gov/people/thomas-o-metz ) is Senior Scientist, Laboratory Fellow and Principal Investigator, in the Integrative Omics group, within the Biological Sciences Division, of the Pacific Northwest National Laboratory (PNNL), where his research focuses on development and applications of high throughput metabolomics and lipidomics methods, in conjunction with proteomics, to answer various biological questions. Currently, Dr. Metz is the director of the Pacific Northwest Advanced Compound Identification Core within the NIH Common Fund Metabolomics Program, co-PI of the Proteomics Laboratory for The Environmental Determinants of Diabetes in the Young consortium, Lead of the PNNL m/q Initiative, and an adjunct faculty member in the Department of Biochemistry and Biophysics at Oregon State University. With a BS in Biology, Frostburg State University, a BS in Chemistry, San Jose State University, and a PhD in Chemistry, University of South Carolina, Dr. Metz's work has resulted in more than 180 publications to date. Pacific Northwest National Laboratory is one of the United States Department of Energy national laboratories, managed by the Department of Energy's Office of Science. They are focused on advancing the frontiers of knowledge, taking on some of the world's greatest science and technology challenges. Distinctive strengths in chemistry, Earth sciences, biology, and data science are central to their scientific discovery mission and their research lays a foundation for innovations that advance sustainable energy through decarbonization and energy storage and enhance national security through nuclear materials and threat analyses. PNNL collaborates with academia in fundamental research and with industry to transition technologies to market. Support the show

Today we are talking about the exposome. This is a crucial topic that needs to be discussed. Once you understand this concept – and I get that it may not sound like a sexy topic. But trust me – once you understand this - you can't unlearn it – it will be lifechanging. We're first going to define what exactly is the exposome. Then we're going to discuss the ramifications of the exposome – why does it matter - and finally we're going to talk about what you can do to improve your odds. Just a quick disclaimer that this podcast is meant for educational purposes only and is not meant to diagnose or be a substitute for medical advice from your practitioner. **Follow me on Instagram: https://www.instagram.com/thefunctionalnursepractitioner/ ** Level up your products: https://www.ewg.org/ewgverified/ **Interesting articles for more information** The Exposome and Toxicology: A Win–Win Collaboration: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9019839/pdf/kfab149.pdf Associations between the Maternal Exposome and Metabolome during Pregnancy: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901044/pdf/ehp9745.pdf The Exposome Paradigm to Understand the Environmental Origins of Mental Disorders: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9590645/pdf/ap-22-4-171.pdf Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237327/pdf/fpubh-10-871140.pdf Epigenetic Regulation in Exposome-Induced Tumorigenesis: Emerging Roles of ncRNAs: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9032613/pdf/biomolecules-12-00513.pdf Exposome and Immunity Training: How Pathogen Exposure Order Influences Innate Immune Cell Lineage Commitment and Function: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697998/pdf/ijms-21-08462.pdf Advancing tools for human early lifecourse exposome research and translation (ATHLETE): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8683140/pdf/ee9-5-e166.pdf The Socio-Exposome: Advancing Exposure Science and Environmental Justice in a Post-Genomic Era: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5604315/pdf/nihms838202.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.16.520731v1?rss=1 Authors: Bartlome, S., Xiao, Y., Ross, E., Dalby, M. J., Berry, C. C. Abstract: Breast cancer is the leading cause of cancer mortality in women worldwide and commonly metastasizes to the bone marrow, drastically reducing patient prognosis and survival. In the bone marrow niche, metastatic cells can enter into a dormant state, thereby evading immune surveillance and treatment, and can be reactivated to enter a proliferative state due to poorly understood cues. Mesenchymal stromal cells (MSCs) maintain cells in this niche partly by secreting extracellular matrix and paracrine factors and by responding to regenerative cues. MSCs also produce extracellular vesicles (EVs) that carry a range of cargoes, some of which are implicated in cell signalling. Here, we investigate if the changing metabolic state of MSCs alters the cargoes they package into EVs, and how these changing cargoes act on dormant breast cancer cells (BCCs) using an in vitro BCC spheroid model and a scratch assay to create a regenerative demand on MSCs. Our findings show that EVs produced by standard MSCs contain glycolytic metabolites that maintain BCC dormancy. When MSCs are placed under a regenerative demand and increase their respiration to fuel differentiation, these metabolites disappear from the EV cargo and their absence encourages rapid growth in the BCC spheroids. This work implicates EVs in cancer cell dormancy in the bone marrow niche and indicates that pressures on the niche, such as regeneration, can be a driver of BCC activation. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

https://psychiatry.dev/wp-content/uploads/speaker/post-9787.mp3?cb=1663689895.mp3 Playback speed: 0.8x 1x 1.3x 1.6x 2x Download: Association Between Human Blood: Journal of the American Society of Hematology Metabolome and the Risk of Psychiatric Disorders – PubMed YimingFull EntryAssociation Between Human Blood Metabolome and the Risk of Psychiatric Disorders – PubMed

What is microbiological memory and what does it have to do with Diabesity? https://www.frontiersin.org/articles/10.3389/fmicb.2018.01379/full The Microbiological Memory, an Epigenetic Regulator Governing the Balance Between Good Health and Metabolic Disorders Christian A. Devaux1,2* and Didier Raoult1 The microbiome and Type 2 Diabetes Can we inherit type two diabetes? Who is Albert Stunkard ? The spark of the diabesity epidemic These are the guidelines that made the diabesity epidemic worse Ztime Podcast Emotional Wellbeing, Physical wellbeing, relationship wellbeing, financial wellbeing, community wellbeing. Ztime Podcast. Dr. Andres Zuleta, Andres Zuleta MD, Dr. Zuleta Diabetes and obesity epidemic. Diabetes remission, Type 2 Diabetes How did we get to this obesity epidemic Dietary goals for the United States / prepared by the staff of the Select Committee on Nutrition and Human Needs, United States Senate. United States. Washington : U.S. Govt. Print. Off., 1977. http://hdl.handle.net/2027/uiug.30112023368936 George Mcgovern The genetics of type 2 diabetes. Parental olfactory experience influences behavior and neural structure in subsequent generations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923835/ Reversing Behavioral, Neuroanatomical, and Germline Influences of Intergenerational Stress https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326876/

In this episode, the team discuss the metabolome; the billions of tiny molecules that our cells produce every second. Scientific understanding of the metabolome has leapt forward, opening the door to a better understanding of how to treat disease, how to live a healthier lifestyle and even how trauma can be passed down via our metabolites. Today's episode is brought to you by SCIEX.  Read more from this podcast: Wellness and Illness From a Precision Quantification Perspective Disease Biomarker Discovery Infographic What's Your (Metabo)Type?  Trauma Impacts the Metabolism in Ways That Can Be Inherited

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2020.09.10.289561v1?rss=1 Authors: Kim, L.-J., Chalmers, T. J., Smith, G. C., Das, A., Poon, E. W. K., Wang, J., Tucker, S. P., Sinclair, D. A., Quek, L.-E., Wu, L. E. Abstract: Nicotinamide mononucleotide (NMN) is a prominent strategy to raise nicotinamide adenine dinucleotide (NAD+) levels, where it is assumed that exogenous NMN is directly incorporated into NAD+ by the canonical recycling pathway. This redox cofactor is required across evolution, including bacteria in the gut microbiome, which can de-amidate NMN to nicotinic acid mononucleotide (NaMN). Here, we sought to determine whether orally delivered NMN undergoes microbial de-amidation into NaMN prior to its uptake. We designed NMN isotopologues with 13C and 15N labelling at strategic positions to indicate incorporation into the NAD+ metabolome via the amidated or deamidated pathways, which were delivered to animals treated with antibiotics to deplete the gut microbiome. We provide evidence for NMN de-amidation by the microbiome prior to its incorporation in vivo. Microbiome depletion increased the overall abundance of NAD+ metabolites, suggesting a competition relationship. Strikingly, treatment with labelled NMN profoundly increased the production of unlabelled NAD+ precursors, suggesting that exogenous NMN impacts the NAD metabolome through indirect means, rather than through its direct incorporation. These results suggest the gut microbiome moderates and alters the assimilation of orally delivered NMN. Copy rights belong to original authors. Visit the link for more info

Million dollar bills for Coronavirus treatments -- we need a national healthcare system! Safe levels of coffee drinking, which has good antioxidant properties; Mea culpa for confusing Omega 3 and Omega 6 in discussion of seed oils last week; New research for drugs and berberine to lower cholesterol; More research reviews from the virtual IFM conference: Dr. Nathan Price, Institute for Systems Biology -- Detailed health monitoring reveals the Metabolome and interactions with the microbiome; Genetic complexities in lowering cholesterol; Omega 3 oils are bad if you have ALS -- A heavy metals effect? The very difficult problem of good design for nutrition research -- The central question is What To Eat to be healthy! Promising new treatment for Turettes Syndrome; Herpes virus and Alzheimers research using minibrain cell cultures

Million dollar bills for Coronavirus treatments -- we need a national healthcare system! Safe levels of coffee drinking, which has good antioxidant properties; Mea culpa for confusing Omega 3 and Omega 6 in discussion of seed oils last week; New research for drugs and berberine to lower cholesterol; More research reviews from the virtual IFM conference: Dr. Nathan Price, Institute for Systems Biology -- Detailed health monitoring reveals the Metabolome and interactions with the microbiome; Genetic complexities in lowering cholesterol; Omega 3 oils are bad if you have ALS -- A heavy metals effect? The very difficult problem of good design for nutrition research -- The central question is What To Eat to be healthy! Promising new treatment for Turettes Syndrome; Herpes virus and Alzheimers research using minibrain cell cultures

Dr. Ted Achacoso is the founding pioneer of "Health Optimization Medicine and Practice" which is the clinical framework of the detection and correction of imbalances at the level of the metabolome. Dr. Ted is board certified in both anti-aging medicine and nutritional medicine in Paris. He is also trained in medical informatics, medical statistics, and artificial intelligence. He was trained in pharmacology, toxicology, neurology, and he maintains a tricontinental practice in health optimization medicine. He also formulated Blue Cannatine, of the Troscriptions brand, which is one of the most sought after nootropics in the biohacking world. I am so grateful that he took the time to have this conversation and share his knowledge with all of us! As this extremely informative conversation lasted 3 hours, I have split it into two episodes so you guys can fully absorb the information that Dr. Ted shares with us. In part 1 of this episode we go into health optimization medicine and what that means from a clinical standpoint and at the individual level. We also talk about everything from balancing hormones, balancing the metabolome, epigenetics, and mental health. This is a fully jam-packed hour of learning. Make sure to tune into next week's episode, where Dr. Ted and I actually get into more of the esoteric aspects of health and medicine. We talk a lot about personal development and spiritual health. On this episode we discuss: - Why chronic diseases are just signs/symptoms of aging - How the body is made up of a number of interacting organisms - Inter-kingdom crosstalk between bacteria and human cells - organisms can directly influence our DNA - How we can use our understanding of epigentics to fine tune our environmental inputs - How our microbiota changes based on where we live - The concerns behind rising levels of mercury and cadmium in our environment - nnEMF exposure and it's influence on the microbiota - Endocrine disrupter compounds - Why it's important to get your body to a healthly baseline first, before optimizing with "fun biotech" - Why you will respond better to nootropics if your neurotransmitters are in balance - What healthy brain function and balanced neurotransmitters look like, and what to aim for before trying nootropics. - How to use correlative statistics to effectively measure your neurotransmitter levels by looking at your metabolites. - The importance of assessing your current levels of vitamins and then supplement accordingly. - Why it's important to go to your doctor visits prepared with questions, lab tests, and requests that apply to your individual needs and interests - Framing your health as your most valuable asset - Understanding that healing and balancing can take time and is not always immediate - The Horvath epigenetic clock and telomere age testing - Connect with Dr Ted: - BioBalance Institute: https://biobalanceinstitute.com/ - HOMe/HOPe Associate: www.homehope.org - Health Optimization Medicine and Practice: www.facebook.com/healthoptimizationmedicine - TroScriptions Instagram: https://instagram.com/troscriptions Connect with Kayla: - Instagram: https://instagram.com/biocurious_kayla?igshid=13k16wei10ytd - Web: https://www.biocuriouskayla.com Sponsors: The Genius Brand: https://thegeniusbrand.com/?rfsn=3471709.90104c Listener discount code: BIOCURIOUS Biostrap: https://biostrap.com/select-your-set?ref=kaylaosterhoff Listener discount code: BIOCURIOUS20 Thrive Probiotics: https://justthrivehealth.com/?rfsn=2974814.0ee52f Listener discount code: BIOCURIOUS --- Send in a voice message: https://anchor.fm/biocurious/message

We are excited to bring you a fascinating interview about our microbiome with Pedram Shojai from Well.org this week! Tune in to understand how our microbiome is the ecosystem of our lives. You’ll learn how your gut health affects your immunity and mental health. And the new fascinating discoveries being made about the bacteria in our tissues and organs and how they support healthy function. You don’t want to miss Pedram’s tips for ensuring you tend a happy healthy microbiome. It all starts in 3...2...1!   * * *   Dr. Pedram Shojai is a man with many titles. He is the founder of Well.Org, the NYT Best Selling author of The Urban Monk, Rise and Shine, and The Art of Stopping Time. He’s the producer and director of the movies “Vitality,” “Origins.” And “Prosperity.” In his spare time, he’s also a Taoist Abbot, a doctor of Oriental medicine, a Kung Fu world traveler, a fierce global green warrior, an avid backpacker, a devout alchemist, a Qi Gong Master, and an old school Jedi bio-hacker working to preserve our natural world and wake us up to our full potential.   The Ecosystem of Life - Your Microbiome Science has now shown is that we are much more intimately connected with all the life on the planet than we ever knew through the bacteria, viruses, protozoa, nematodes, even parasites that live inside our body. There's RNA and DNA that we can now analyze on these bugs and understand how they support many human functions. These functions are actually attributed to these bacteria that are co-existing with us. The word is symbiosis. All of this life in and around us is part of what makes us human and without it, we collapse, and we fall ill. If you don't have proper gut health and you're not supporting the life inside of you, there are entire systems that are collapsing that are leading to inflammation and chronic disease.   Where It All Begins The first inoculation of our microbiome is as we come through the birth canal. 30% of mom's breast milk are these oligosaccharides that get secreted by mom. They are indigestible by baby. They're specifically designed to feed the bacteria in the baby's gut. Now fast forward here, you need to eat the fiber, vegetables, phytonutrients, and all these things that these bacteria eat, not for you but for the bacteria. If we put them first and understand how to feed them, they take care of us and in turn we get less illness, less chronic disease, we have more energy, things work.   Every Tissue, Every Organ In The Body Has Bacteria Associated With It Researchers found that women with tumors in their breasts had a different mix of bacteria living in the tissue compared with women who did not have tumors. The research team discovered for the first time that healthy breast tissue contains more of the bacterial species Methyl bacterium. It is blowing the doors open on everything we know about medicine and this is just the beginning.   The Microbiome and Your Immunity About 70% or so of our immune system is around our guts, it's called the gut associated lymphatic tissue. The bacteria are acting as the sentinels between the outside world and the inside world and telling the immune system that everything is good. You can't heal if your immune system is constantly battling and that all starts in the gut and that all has to do with how the microbiome is informing the immune system to either attack or to relax and it will do so based on what is in there.   What Lifestyles Are Destroying Our Microbiome and Causing Leaky Gut? Standard American Diet Not enough prebiotics to feed the good bacteria. Food allergies like gluten and dairy.   Why Leaky Gut Matters Once you start creating inflammation and tears in the lining of the gut, there are food particles that will sneak through and the immune system says, "Hey, you're not supposed to be on this side." It will start to create antibodies to those food particles as foreign invaders. This is how food allergies are created. Creates systemic inflammation throughout the body.   How to Improve Your Microbiome Work with a Functional Medicine Doctor. Analysis of your microbiome. You look at how we need to eat and ‘who’ we need to feed. Include indigestible fiber in your daily diet. You consume a variety of fermented foods and prebiotic foods with every single meal and you adjust for feeding the bacteria that help you thrive. Reduce sugar in your diet. By bringing down the bacteria, specifically like the yeast and bad bacteria that thrive on sugars in particular, you'll start to notice a difference very quickly. Increase fiber intake.   Benefits of a Healthy Microbiome Brain fog dissipates. Anxiety and depression reduced. Energy levels increase. Excess weight is released.   What Role Do Parasites Play in Gut Health? We're finding that there's certain parasites that help bring down your blood sugar. Certain parasites will help you offset certain disease processes. The research in new and ongoing in this area.     Deeper Dive Resources   Interconnected Docuseries https://of535.isrefer.com/go/start/Organixx/podcast-20190424   Well.org https://www.well.org/   Viome - At Home Gut Microbiome Testing https://www.viome.com/   Metabolome https://en.wikipedia.org/wiki/Metabolome   Symbiosis https://en.wikipedia.org/wiki/Symbiosis   Cleveland Clinic Researchers Find Link Between Bacterial Imbalances and Breast Cancer https://newsroom.clevelandclinic.org/2017/10/05/cleveland-clinic-researchers-find-link-between-bacterial-imbalances-and-breast-cancer/   What prebiotic foods should people eat? https://www.medicalnewstoday.com/articles/323214.php   11 Probiotic Foods That Are Super Healthy https://www.healthline.com/nutrition/11-super-healthy-probiotic-foods   Gut-associated lymphoid tissue https://en.wikipedia.org/wiki/Gut-associated_lymphoid_tissue   Intestinal permeability https://en.wikipedia.org/wiki/Intestinal_permeability   Candidiasis https://www.health.harvard.edu/a_to_z/candidiasis-a-to-z   The Institute for Functional Medicine https://www.ifm.org/   The Hygiene Hypothesis http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.570.9502&rep=rep1&type=pdf https://www.livescience.com/54078-hygiene-hypothesis.html

We are excited to bring you a fascinating interview about our microbiome with Pedram Shojai from Well.org this week! Tune in to understand how our microbiome is the ecosystem of our lives. You’ll learn how your gut health affects your immunity and mental health. And the new fascinating discoveries being made about the bacteria in our tissues and organs and how they support healthy function. You don’t want to miss Pedram’s tips for ensuring you tend a happy healthy microbiome. It all starts in 3...2...1!   * * *   Dr. Pedram Shojai is a man with many titles. He is the founder of Well.Org, the NYT Best Selling author of The Urban Monk, Rise and Shine, and The Art of Stopping Time. He’s the producer and director of the movies “Vitality,” “Origins.” And “Prosperity.” In his spare time, he’s also a Taoist Abbot, a doctor of Oriental medicine, a Kung Fu world traveler, a fierce global green warrior, an avid backpacker, a devout alchemist, a Qi Gong Master, and an old school Jedi bio-hacker working to preserve our natural world and wake us up to our full potential.   The Ecosystem of Life - Your Microbiome Science has now shown is that we are much more intimately connected with all the life on the planet than we ever knew through the bacteria, viruses, protozoa, nematodes, even parasites that live inside our body. There's RNA and DNA that we can now analyze on these bugs and understand how they support many human functions. These functions are actually attributed to these bacteria that are co-existing with us. The word is symbiosis. All of this life in and around us is part of what makes us human and without it, we collapse, and we fall ill. If you don't have proper gut health and you're not supporting the life inside of you, there are entire systems that are collapsing that are leading to inflammation and chronic disease.   Where It All Begins The first inoculation of our microbiome is as we come through the birth canal. 30% of mom's breast milk are these oligosaccharides that get secreted by mom. They are indigestible by baby. They're specifically designed to feed the bacteria in the baby's gut. Now fast forward here, you need to eat the fiber, vegetables, phytonutrients, and all these things that these bacteria eat, not for you but for the bacteria. If we put them first and understand how to feed them, they take care of us and in turn we get less illness, less chronic disease, we have more energy, things work.   Every Tissue, Every Organ In The Body Has Bacteria Associated With It Researchers found that women with tumors in their breasts had a different mix of bacteria living in the tissue compared with women who did not have tumors. The research team discovered for the first time that healthy breast tissue contains more of the bacterial species Methyl bacterium. It is blowing the doors open on everything we know about medicine and this is just the beginning.   The Microbiome and Your Immunity About 70% or so of our immune system is around our guts, it's called the gut associated lymphatic tissue. The bacteria are acting as the sentinels between the outside world and the inside world and telling the immune system that everything is good. You can't heal if your immune system is constantly battling and that all starts in the gut and that all has to do with how the microbiome is informing the immune system to either attack or to relax and it will do so based on what is in there.   What Lifestyles Are Destroying Our Microbiome and Causing Leaky Gut? Standard American Diet Not enough prebiotics to feed the good bacteria. Food allergies like gluten and dairy.   Why Leaky Gut Matters Once you start creating inflammation and tears in the lining of the gut, there are food particles that will sneak through and the immune system says, "Hey, you're not supposed to be on this side." It will start to create antibodies to those food particles as foreign invaders. This is how food allergies are created. Creates systemic inflammation throughout the body.   How to Improve Your Microbiome Work with a Functional Medicine Doctor. Analysis of your microbiome. You look at how we need to eat and ‘who’ we need to feed. Include indigestible fiber in your daily diet. You consume a variety of fermented foods and prebiotic foods with every single meal and you adjust for feeding the bacteria that help you thrive. Reduce sugar in your diet. By bringing down the bacteria, specifically like the yeast and bad bacteria that thrive on sugars in particular, you'll start to notice a difference very quickly. Increase fiber intake.   Benefits of a Healthy Microbiome Brain fog dissipates. Anxiety and depression reduced. Energy levels increase. Excess weight is released.   What Role Do Parasites Play in Gut Health? We're finding that there's certain parasites that help bring down your blood sugar. Certain parasites will help you offset certain disease processes. The research in new and ongoing in this area.     Deeper Dive Resources   Interconnected Docuseries https://of535.isrefer.com/go/start/Organixx/podcast-20190424   Well.org https://www.well.org/   Viome - At Home Gut Microbiome Testing https://www.viome.com/   Metabolome https://en.wikipedia.org/wiki/Metabolome   Symbiosis https://en.wikipedia.org/wiki/Symbiosis   Cleveland Clinic Researchers Find Link Between Bacterial Imbalances and Breast Cancer https://newsroom.clevelandclinic.org/2017/10/05/cleveland-clinic-researchers-find-link-between-bacterial-imbalances-and-breast-cancer/   What prebiotic foods should people eat? https://www.medicalnewstoday.com/articles/323214.php   11 Probiotic Foods That Are Super Healthy https://www.healthline.com/nutrition/11-super-healthy-probiotic-foods   Gut-associated lymphoid tissue https://en.wikipedia.org/wiki/Gut-associated_lymphoid_tissue   Intestinal permeability https://en.wikipedia.org/wiki/Intestinal_permeability   Candidiasis https://www.health.harvard.edu/a_to_z/candidiasis-a-to-z   The Institute for Functional Medicine https://www.ifm.org/   The Hygiene Hypothesis http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.570.9502&rep=rep1&type=pdf https://www.livescience.com/54078-hygiene-hypothesis.html

Robert Martindale, MD, PhD, discusses the metabolome of the microbiome, including case studies.

A paper in the March 2018 issue of Clinical Chemistry describes a liquid chromatography tandem mass spectrometry procedure for multi-steroid profiling in Cushing syndrome and other disorders.  The lead author of that study is Dr. Graeme Eisenhofer, who is professor and the Chief of the Division of Clinical Neurochemistry at the Institute for Clinical Chemistry and Laboratory Medicine at the Technical University in Dresden, Germany.  He is our guest in this podcast.

Get ready because this episode takes us 5-10 years into the future - where Big Data meets Alzheimer's. But the future is already here! Dr Nathan Price PhD is the associate director of the highly esteemed Institute for Systems Biology (ISB) and co-founder of it's spin-off company Arivale - a leading company in the Scientific Wellness space. ISB and Providence St. Joseph Health, a 50 hospital system to which ISB is affiliated, have particularly focused on solving Alzheimer’s and have invested millions of dollars into research in finding both cures and prevention programs. Dr Price gives us an intro to the concept of "Scientific Wellness" and it's role in creating health and predicting and preventing disease.  Scientific Wellness - refers to technologies that quantify and assist to enhance health in the human body.  Using methods of measurement called "Computational Biology" this approach builds models to make sense of disease and resilience states and gain insights from vast amounts of information generated using computer technology.  This information can be from a person's genes or gene expression products or even the bugs in their stool and saliva. In some cases these methods may even try to make sense of data streams collected by a variety of sensor-based information (for example, from a FITBIT).   All of this information can be overwhelming to handle and requires "supercomputing" capacity which companies like Arivale and ISB possess. Dr Price and I discuss how all of this information comes together in the case of Alzheimer's disease in the form of "dense dynamic personal data clouds" and how this will likely be important in solving the Alzheimer's puzzle.  Dense dynamic personal data clouds - refer to huge data sets that are followed on individuals over time to help predict and prevent disease. The first such project was called the "Pioneer 100." While some of these data collections are investigational at this time, the near term goal is to leverage these data to practical help people get better or possible prevent Alzheimer's.  In order to make sense of an individual's information, his/her genome need to be compared against what is know about Alzheimer's in the highly touted Genome Wide Association Studies (GWAS).  GWAS data are important because they tell you about gene variations that are associated with a variety of aspects of Alzheimer's disease. Fortunately, there is good GWAS data for Alzheimer's and based on this, Dr Price and his team at Arivale believe that this will help track the manifestation of Alzheimer's disease based on tracking way the way genes express in a variety of other measurable data from a human being. This information is collected from multiple levels of a person including stool, saliva, urine, blood and potentially more. The variety of levels of "Omic" information is aggregated then with the assistance of computer technology is made sense of in the form of a "dense dynamic personalized data cloud." Other Interesting Topics discussed in this episode Connections between diabetes type 2 and Alzheimer's a Where stem cells might have a role in treatment. CRISPR technology - the benefits and ethical questions of gene-editing technology. I want to highlight CRISPR in this summary because of how significant it appears it will be in the future of achieving real health on multiple levels.  CRISPR is a gene-editing tool - that Dr Price calls one of the most exciting developments in biology in his generation. CRISPR is a simple technique for gene editing that allows someone to effectively "pull out" risky genes at the stem cell level, fix them, and put them back. But, Dr Price also considers the ethics and potential unintended consequences. Changing the paradigm of how clinical research is done in the Information Age.  In the age of Personalized Medicine the paradigm of the single pill for a single ill is being challenged and a new approach for clinical trials is emerging with ISB amongst the leaders of this emerging paradigm.  Find out more about Dr Price's work here: The Institute for Systems Biology Arivale

Hosts: Vincent Racaniello, Michael Schmidt, Elio Schaechter and Michele Swanson.   The TWiM team discusses how measles vaccination protects against other infectious diseases, and links between bacterial biofilms and colon cancer. Subscribe to TWiM (free) on iTunes, Stitcher, RSS, or by email. You can also listen on your mobile device with the Microbeworld app. Links for this episode Measles vaccination prevents all-cause infectious disease (Science) Master of contagion (The Loom) Video: Measles incidence to immunomodulation (Science) FAQ: Adult vaccines Metabolism links biofilms and colon cancer (Cell Metab) Scripps Center for Metabolomics Scripps metabolite database Image credit Sponsors for this episode: SciMedSolutions, ICAAC-ICC Send your microbiology questions and comments (email or mp3 file) to twim@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twim.  

Some of the most powerful and useful things in our world come from plants. Who knew they could help us unlock some of the biology's mysteries - all using an approach of mapping biological pathways! ---------- Find us online! Facebook: http://www.facebook.com/MITK12 Twitter: http://www.twitter.com/MITK12Videos http://k12videos.mit.edu ---------- made with love at MIT Creative Commons: CC BY-NC-SA http://k12videos.mit.edu/terms-and-conditions Hosted and written by: Anastassia Bobokalonova Additional scripting: Elizabeth Choe, George Zaidan Executive producer: Elizabeth Choe Director: George Zaidan Editor: Per Hoel (http://perhoel.org/) Production assistants: Conor Olmstead, Ryan Pelletier Doodles by Elizabeth Choe, animated by Per Hoel Special thanks: Valentina Carballo, Jing-Ke Weng, Whitehead Institute Music: Easy Math (http://www.premiumbeat.com/royalty_free_music/songs/easy-math) Rattle your Cage by Karckatoa (http://freemusicarchive.org/music/krackatoa/The_Universal_Fluff_Theory/Krackatoa-The_Universal_Fluff_Theory-06-Rattle_your_Cage) Images: Boston metro map (http://en.wikipedia.org/wiki/Massachusetts_Bay_Transportation_Authority#mediaviewer/File:MBTA_Boston_subway_map.png) Metabolome network image (http://www.helmholtz-muenchen.de/en/eus/research/abiotic-stress-resistance-and-resource-use-efficiency/plant-metabolome-analysis/index.html) Satellite image JAXA (https://twitter.com/Astro_Soichi)

A study in the July issue of CGH compares the colonic microbiome and volatile organic compound metabolome of obese nonalcoholic fatty liver disease patients with that of healthy-weight individuals. Dr. Kuemmerle speaks to author Dr. Kevin P. Rioux.

Hosts: Vincent Racaniello and Kathy Spindler Guests: Nels Elde and Tom Shenk Vincent and Kathy recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Nels and Tom about their work on the evolution of virus-host conflict and how viruses influence the cell metabolome. Links for this episode:  A cross-species view on viruses (Curr Op Virol) Pox has got a squeeze box (TWiV 198) Saturated fatty acids needed for CMV (PLoS Path) CMV and HSV metabolomes differ (PLoS Path) Video of this episode - view at YouTube Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv

Hosts: Vincent Racaniello and Rich Condit Vincent and Rich discuss recovery of a hepatitis B viral genome from a 16th century Korean mummy, and personal omics profiling of an individual over a 14 month period. Links for this episode: Tracing HBV to the 16th century (Hepatology) HBV on TWiV Precautions with ancient DNA (Science) Personal omics profile over 14 months (Cell) A geneticist's research turns personal (NY Times) Mike Snyder on Futures in Biotech The DASH diet TWiV on Facebook Letters read on TWiV 187 Weekly Science Picks Rich - The Checklist by Atul GawandeVincent - Artologica Listener Pick of the Week David - Cracking your genetic code (Nova)Josh - The nuclearization of biology is a threat to health and security (pdf) Send your virology questions and comments (email or mp3 file) to twiv@twiv.tv, or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

Background: Genome-wide association studies (GWAS) with metabolic traits and metabolome-wide association studies (MWAS) with traits of biomedical relevance are powerful tools to identify the contribution of genetic, environmental and lifestyle factors to the etiology of complex diseases. Hypothesis-free testing of ratios between all possible metabolite pairs in GWAS and MWAS has proven to be an innovative approach in the discovery of new biologically meaningful associations. The p-gain statistic was introduced as an ad-hoc measure to determine whether a ratio between two metabolite concentrations carries more information than the two corresponding metabolite concentrations alone. So far, only a rule of thumb was applied to determine the significance of the p-gain. Results: Here we explore the statistical properties of the p-gain through simulation of its density and by sampling of experimental data. We derive critical values of the p-gain for different levels of correlation between metabolite pairs and show that B/(2*alpha) is a conservative critical value for the p-gain, where a is the level of significance and B the number of tested metabolite pairs. Conclusions: We show that the p-gain is a well defined measure that can be used to identify statistically significant metabolite ratios in association studies and provide a conservative significance cut-off for the p-gain for use in future association studies with metabolic traits.