Podcasts about PBC

Rejoice, the Lord Is King! - Psalm 47 Ryan Adams

On the segment of "Real Talk", the Ring Gang crew discuss PBC debuting on DAZN

Juan shares his thoughts and feelings about the latest news in the sport of boxing. Shakur Stevenson signs with Zuffa, PBC signs with DAZN, Richardson Hitchins signs an affidavit.

With this podcast, featuring audio from a Medical Minute webcast, expert faculty Maria Londoño, MD, PhD, discusses how recent clinical trial and real-world data can improve treatment plans for patients with PBC. Listen now and visit the program page to download the accompanying slides. Topics covered include: Real-world Evidence for Treatment with PPAR Agonists PPAR Agonists for People With Prior Second-line Treatment PPARs Agonists for People With ALP 1.00-1.67x ULN Biochemical Response and Liver Stiffness Get access to all of our new podcasts by subscribing to the Decera Clinical Education Medical Specialties Podcast on Apple Podcasts, YouTube Music, or Spotify. Presenters:  Maria Londoño, MD, PhD Consultant Hepatologist Hospital Clinic Barcelona Associate Professor University of Barcelona Barcelona, Spain Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Episode SummaryRecorded live at the San Diego Angel Conference finale at SDSU, Eric Ries — author of The Lean Startup — sits down with product leader and founder coach Vidya Dinamani to unpack his new book, Incorruptible. His argument: there's a gravitational force that pulls even mission-driven companies toward decay — “the making of money without the creating of value” — and the more successful you get, the bigger a target you become. Eric walks through how it happens (stack-ranking by ROI, the “what would investors want” ghost in every meeting, Groupon's two-emails-a-day spiral), why the fix has to come earlier than anyone wants (“it's too early until it's too late”), and the concrete governance moves that keep the great ones honest. Along the way: the San Diego origin story of Costco, Cloudflare giving away its best paid feature, Anthropic's long-term benefit trust, a hard-nosed take on AI, and a health insurer whose customer-service reps act like guardian angels.Key Topics* Corruption as “making money without creating value”* The gravity that pulls companies from mission to mediocrity* Costco's San Diego origin — and why FedMart died* Why stack-ranking by ROI buries the work that builds trust* “It's too early until it's too late” — protecting the mission in time* The PBC filing and binding your board to the mission* AI as a “Dunning-Kruger factory,” and how to actually use it* “Love” as an operating framework: the Devoted Health storyLinks & Resources* Incorruptible* The Lean Startup* Long-Term Stock Exchange (LTSE)* San Diego Angel ConferenceConnect on LinkedIn* Neal Bloom * Eric Ries* Vidya Dinamani This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit risingtidepartners.substack.com/subscribe

In this episode, Lukie and Dakota start with the news. Four-division titleholder Shakur Stevenson signed with Zuffa Boxing. With rumors that Oleksandr Usyk and Devin Haney may sign with Zuffa, is the takeover imminent? What are the guys' thoughts on this? Then, we shift to PBC announcing a deal with DAZN, which would have seemed unheard of before this year. Is this a direct response to Zuffa Boxing? They announced a few fights (without official fight dates), but in August WBA welterweight champ Rolando Romero will face Teofimo Lopez. The guys give early thoughts on this fight.The guys recap a very light week of boxing. Murat Gassiev stopped late-sub Peter Kadiru in six rounds. Kadiru filled in for Gassiev's original opponent, 2016 French Olympic gold medalist Tony Yoka, but was outgunned. Also, Artem Suslenkov stopped former contender Joe Joyce in what should be Joyce's last pro fight. The ending was very sad. Then, we look ahead. Another light week of boxing.Super middleweight Diego Pacheco faces Immanuwel Aleem. It is a DAZN main event bout, and the return of boxing to the Dignity Health Sports Park in Carson, California. Lightweight Andy Cruz will face Abraham Montoya, after his original opponent, Albert Bell, fought Abdullah Mason on short notice earlier this month. Middleweight Frank Espinoza and lightweight Sammy Contreras Jr are notable prospects to watch, but a good 50-50 fight to watch for is Saul Sanchez vs. unbeaten Bruno Rios. Heavyweight Leo Atang is someone I keep wondering just how good he is, too. In the U.K., welterweight Harlem Eubank is in tough against David Papot, and on ProBox TV an assortment of fights including Bryan Flores vs. Jonathan Navarro, junior middleweight Kevin Anton vs. Vladimir Hernandez, and Charly Suarez vs. Manuel "Tino" Avila.Timestamps:0:00 Shakur to Zuffa Boxing12:03 PBC to DAZN20:55 Teofimo Lopez vs Rolando Romero29:30 Joe Joyce, Murat Gassiev40:00 Diego Pacheco returns46:40 undercard56:37 Other stuff

Who Is Your Fortress? - Psalm 46 Ryan Adams

The boxing world delivered another week of huge headlines, and we're breaking down everything on this episode of Ringside Reporter! We recap DAZN's heavyweight card from Moscow as Murat Gassiev defends his WBA "Regular" Heavyweight Title against Peter Kadiru, plus Joe Joyce returns against Artem Suslenkov in a pivotal heavyweight showdown. We also discuss UFC 329, featuring Conor McGregor's return against Max Holloway, and what it could mean for combat sports as a whole. Then it's time for the biggest stories in boxing:

We're back and ready for a lighter weekend where the most prominent fight is in Russia, of all places. But, we've got a huge name joining us to discuss his new multi-fight promotional deal, and fight news, as well. It's all part of the "Big Fight Weekend Preview Podcast!' Host T.J. Rives is back with insider Dan Rafael of his Fight Freaks Unite Substack and Newsletter are ready to go over it all.First, they preview of Saturday's IBA/Epic Sports card on DAZN in MoscowMurat Gassiev vs. Peter Kadiru, for Gassiev's WBA “regular” heavyweight title. We go over the matchup with the last minute repladcement German and the tepid impact the fight will likely have, but it's a fight for a portion of the heavyweight crown.In the co-feature Englishman Joe Joyce vs. Russian prospect Artem Suslenkov, 10 rounds, heavyweights. Does Joyce have anything left or will the Russian mow him down?Then, hear Shakur Stevenson one on one with DanHe is interviewed hours after the Thursday announcement of his signing with Zuffa Boxing. They disucss what it means for his next fight and when, etc.? Next, some newsWBA welterweight titlist Rolly Romero vs. Teofimo Lopez announced, presser was Thursday in LA. Aug. 22 at T-Mobile Arena. We go over it.Also announced at their presser – PBC/DAZN deal. We go over some of the details and is it eventually the end of PBC on Amazon Prime?The back and forth over the timing of Fury-Joshua continues – Turki Alashikh says the fight will be in the U.K. if the main event is at 2 a.m. London time to accommodate U.S. prime time on Netflix, there's usually an 11 pm local time  curfew for Wembley events. What are we doing here?!Former unified heavyweight titleholder Andy Ruiz Jr., who has boxed just three times this decade, will return to the ring to fight on DAZN after signing a multi-fight promotional contract with Matchroom Boxing.And, the WBO a expected has ordered lineal/unified light heavyweight champion Dmitry Bivol and interim titlist Callum Smith to begin negotiating the mandatory fight.Hear it all on the "Big Fight Weekend Preview" and make sure to follow/subscribe on Apple/Spreaker/Spotify, etc.!

We're back and ready for a lighter weekend where the most prominent fight is in Russia, of all places. But, we've got a huge name joining us to discuss his new multi-fight promotional deal, and fight news, as well. It's all part of the "Big Fight Weekend Preview Podcast!' Host T.J. Rives is back with insider Dan Rafael of his Fight Freaks Unite Substack and Newsletter are ready to go over it all.First, they preview of Saturday's IBA/Epic Sports card on DAZN in MoscowMurat Gassiev vs. Peter Kadiru, for Gassiev's WBA “regular” heavyweight title. We go over the matchup with the last minute repladcement German and the tepid impact the fight will likely have, but it's a fight for a portion of the heavyweight crown.In the co-feature Englishman Joe Joyce vs. Russian prospect Artem Suslenkov, 10 rounds, heavyweights. Does Joyce have anything left or will the Russian mow him down?Then, hear Shakur Stevenson one on one with DanHe is interviewed hours after the Thursday announcement of his signing with Zuffa Boxing. They disucss what it means for his next fight and when, etc.? Next, some newsWBA welterweight titlist Rolly Romero vs. Teofimo Lopez announced, presser was Thursday in LA. Aug. 22 at T-Mobile Arena. We go over it.Also announced at their presser – PBC/DAZN deal. We go over some of the details and is it eventually the end of PBC on Amazon Prime?The back and forth over the timing of Fury-Joshua continues – Turki Alashikh says the fight will be in the U.K. if the main event is at 2 a.m. London time to accommodate U.S. prime time on Netflix, there's usually an 11 pm local time  curfew for Wembley events. What are we doing here?!Former unified heavyweight titleholder Andy Ruiz Jr., who has boxed just three times this decade, will return to the ring to fight on DAZN after signing a multi-fight promotional contract with Matchroom Boxing.And, the WBO a expected has ordered lineal/unified light heavyweight champion Dmitry Bivol and interim titlist Callum Smith to begin negotiating the mandatory fight.Hear it all on the "Big Fight Weekend Preview" and make sure to follow/subscribe on Apple/Spreaker/Spotify, etc.!

This episode is brought to you by PPV.COM!  (0:00) - Intro  (3:48) - PBC to join DAZN  (10:33) - Latest Tyson Fury vs. Anthony Joshua  (17:50) - FanDuel weekend picks and odds  (29:14) - 2026 Year in Review  (32:45) - 2026 Mid Year Awards

This episode is brought to you by PPV.COM!  (0:00) - Intro  (3:48) - PBC to join DAZN  (10:33) - Latest Tyson Fury vs. Anthony Joshua  (17:50) - FanDuel weekend picks and odds  (29:14) - 2026 Year in Review  (32:45) - 2026 Mid Year Awards

The Marriage of the King - Psalm 45 Ryan Adams

Why Are You Sleeping, O Lord? - Psalm 44 Ryan Adams

We are back off a lighter weekend in the ring to talk about the chaotic opponent situation for Oscar Collazo's planned strawweight title fight in California and plenty of fight news, too, on the latest "Fight Freaks Unite Recap Podcast!"Host T.J. Rives returns iwth insider Dan Rafael of his Fight Freaks Unite Substack and newletter have their insight and takes.First, they recap Saturday's Golden Boy DAZN main event in Oceanside, CaliforniaCollazo TKO2 over late replacement, Neider Valdez in what turned out to be flyweight non-title fight. We have more on the whole mess with an opponent and what's next for him? Dan also has more briefly on the undercard fights, too.Next, a recap Saturday's Queensberry DAZN main event in Southampton, EnglandJunior lightweight Ryan Garner W12 Michael Magnesi, wins vacant WBC interim title in a very competitive bout. Dan gives his thoughts. Then, some newsThe nastiness of Oscar De La Hoya/Golden Boy's feud with unbeaten contender Vergil Oritz over his contract status may be worked out before the scheduled arbitration for mid July. We have more on the situation and can Ortiz finally get back in the ring?Next, Floyd Mayweather faces two felonies for writing a bad check for $200,000 for a watch in Las Vegas as well as lawsuit from CSI, which has his rights for the Tyson exhibition and Pacquiao rematch, because he took a $4.5 million advance and they say he has breached the contract; they have filed indistrict court in NY to stop his exhibition vs. Mike Zambidis in Athens, Greece, scheduled for this coming Saturday.It's a Done deal, presser on Monday -- heavyweight Moses Itauma and Filip Hrgovic will meet August 29 (DAZN PPV or DAZN Ultimate) at The O2 in London. Hrgovic signed the deal on Friday.Also, PBC announces Spence-Tszyu Prime Video PPV undercard (July 25 in U.S. prime time, Sunday July 26 in Sydney, Australia). It's US vs Australia -- Jermall Charlo, for his first fight in 14 months and third fight since 2021, will face Koen Mazoudier in a 10-round super middleweight fight. Stephen Fulton vs. Liam Wilson in a 12-round junior lightweight fight. 2024 Australian Olympian and middleweight prospect Callum Peters vs. TBA in a 10-rounder The WBA CLAIMS in a statement that it will reduce titles as it had once done AND announced the elimination of the bridgerweight division.Talks going on for a three-belt cruiserweight unification bout between WBA/WBO champ David Benavidez and WBC titleholder Noel Mikaelian. How realistic is this for later in the year?And, the Egyptian Professional Boxing Association denied Rico Verhoeven's appeal of his controversial 11th-round stoppage by lineal/unified heavyweight champion Oleksandr Usyk on May 23 at the Pyramids in Giza, Egypt.It's all part of the "Fight Freaks Unite Recap Podcast" and make sure to follow/subscribe to this feed on Apple/Spreaker/Spotify, etc.! 

We are back off a lighter weekend in the ring to talk about the chaotic opponent situation for Oscar Collazo's planned strawweight title fight in California and plenty of fight news, too, on the latest "Fight Freaks Unite Recap Podcast!"Host T.J. Rives returns iwth insider Dan Rafael of his Fight Freaks Unite Substack and newletter have their insight and takes.First, they recap Saturday's Golden Boy DAZN main event in Oceanside, CaliforniaCollazo TKO2 over late replacement, Neider Valdez in what turned out to be flyweight non-title fight. We have more on the whole mess with an opponent and what's next for him? Dan also has more briefly on the undercard fights, too.Next, a recap Saturday's Queensberry DAZN main event in Southampton, EnglandJunior lightweight Ryan Garner W12 Michael Magnesi, wins vacant WBC interim title in a very competitive bout. Dan gives his thoughts. Then, some newsThe nastiness of Oscar De La Hoya/Golden Boy's feud with unbeaten contender Vergil Oritz over his contract status may be worked out before the scheduled arbitration for mid July. We have more on the situation and can Ortiz finally get back in the ring?Next, Floyd Mayweather faces two felonies for writing a bad check for $200,000 for a watch in Las Vegas as well as lawsuit from CSI, which has his rights for the Tyson exhibition and Pacquiao rematch, because he took a $4.5 million advance and they say he has breached the contract; they have filed indistrict court in NY to stop his exhibition vs. Mike Zambidis in Athens, Greece, scheduled for this coming Saturday.It's a Done deal, presser on Monday -- heavyweight Moses Itauma and Filip Hrgovic will meet August 29 (DAZN PPV or DAZN Ultimate) at The O2 in London. Hrgovic signed the deal on Friday.Also, PBC announces Spence-Tszyu Prime Video PPV undercard (July 25 in U.S. prime time, Sunday July 26 in Sydney, Australia). It's US vs Australia -- Jermall Charlo, for his first fight in 14 months and third fight since 2021, will face Koen Mazoudier in a 10-round super middleweight fight. Stephen Fulton vs. Liam Wilson in a 12-round junior lightweight fight. 2024 Australian Olympian and middleweight prospect Callum Peters vs. TBA in a 10-rounder The WBA CLAIMS in a statement that it will reduce titles as it had once done AND announced the elimination of the bridgerweight division.Talks going on for a three-belt cruiserweight unification bout between WBA/WBO champ David Benavidez and WBC titleholder Noel Mikaelian. How realistic is this for later in the year?And, the Egyptian Professional Boxing Association denied Rico Verhoeven's appeal of his controversial 11th-round stoppage by lineal/unified heavyweight champion Oleksandr Usyk on May 23 at the Pyramids in Giza, Egypt.It's all part of the "Fight Freaks Unite Recap Podcast" and make sure to follow/subscribe to this feed on Apple/Spreaker/Spotify, etc.! 

What Do Yoy Say When You're Hopeless? - Psalms 42 & 43 Ryan Adams

In the Bible profile series, I come to one of the sons of Jacob. The life of Joseph was fraught with disappointment and tragedy, much of which was brought on by bad parenting. But there are beautiful and glorious glimpses of our Savior in the life of Joseph. Joseph

When it comes to studying our Bibles, one important concept we need to understand is the difference between an eternal salvation and a salvation related to the here and now. While it is the finished work of Christ alone that saves us from an eternal hell, there are many things we can do on this …

The way we worship is important to God. For 5 chapters in I Corinthians, the Holy Spirit directed Paul to write about the things that should and should not occur during worship. In this message, I look at this important teaching about what God expects out of us when we publicly worship Him. Tarry

Much debate has occurred over the meaning of the pruning of the vine in John 15. If we simply take the plain words of Jesus in their context, we will learn the valuable lesson He is teaching. In this message, I look at the meaning of the true Vine and how the pruning of the …

Faith Without Favoritism - James James 2: 1-13 Ben Coggin

We are back with a recap of the big win by Jesse "Bam" Rodriguez to caputre a world title, we have plenty of fight news and we have a titlle for the NY Knicks in Pro Basketball and the host is headed on a vacation! We cover it all on the "Fight Freaks Unite Recap Podcast!"Host T.J. Rives is back with insider Dan Rafael of his Fight Freaks Unite Substack and newsletter to give their insight and takes on it all.Dan MUST talk first about his Knicks finally, finally, after 53 years winning the NBA title Saturday night in San Antonio. Has he gotten memorabilla already? Will he be at the parade on Thursday through Manhattan? It's all discussed.T.J. cares only slightly, as he lives in Florida and is headed on a CRUISE with his family after this show!So we are ready to get to it!First, a recap of the Sataurday night Matchroom Boxing main event at Glendale, ArizonaJesse “Bam” Rodriguez KO6 Antonio Vargas and wins WBA bantamweight title. Bam is rolling and is one of the best in the sport. Now, will he get the mega-fight with Naoya Inoue next or not? The guys go over everything. Then, some newsAnnouncement during the Saturday Matchroom card that super middleweight Diego Pacheco will headline against Immanuwel Aleem on July 26 at the Dignity Health Sports Park in Carson, California. Andy Cruz vs. Albert Bell IBF lightweight eliminator in the co-feature.  No is done yet, but PBC is working to make WBA junior welterweight titlist Gary Antuanne Russell to make his second defense against Isaac “Pitbull” Cruz (the WBC interim titlist) in late August or September.  Heavyweight Moses Itauma's summer date has been moved to Aug. 29 in London but the hunt is still on for an opponent as Filip Hrgovic has turned down the fight for August. T.J. wonders on all levels WHAT ARE WE DOING HERE with Itauma, who needs rounds and credibility not fighting more regularly.Next, talks are going on for a mandatory fight between WBA lightweight titlist Gervonta "Tank" Davis and Floyd Schofield. How realistic is this for either of them.Opponents set for Edgar Berlanga and Richardson Hitchins on Zuffa Boxing's NYC debut card July 26 at Madison Square Garden Theater. Berlanga will take on two-time middleweight title challenger Steven Butler and Hitchins, moving up to welterweight, will face Ricardo Salas. Dan has more on the matchups.It's all part of the "Fight Freaks Unite Recap Podcast" and make sure to follow/subscribe on Apple/Spreaker/Spotify, etc.! 

We are back with a recap of the big win by Jesse "Bam" Rodriguez to caputre a world title, we have plenty of fight news and we have a titlle for the NY Knicks in Pro Basketball and the host is headed on a vacation! We cover it all on the "Fight Freaks Unite Recap Podcast!"Host T.J. Rives is back with insider Dan Rafael of his Fight Freaks Unite Substack and newsletter to give their insight and takes on it all.Dan MUST talk first about his Knicks finally, finally, after 53 years winning the NBA title Saturday night in San Antonio. Has he gotten memorabilla already? Will he be at the parade on Thursday through Manhattan? It's all discussed.T.J. cares only slightly, as he lives in Florida and is headed on a CRUISE with his family after this show!So we are ready to get to it!First, a recap of the Sataurday night Matchroom Boxing main event at Glendale, ArizonaJesse “Bam” Rodriguez KO6 Antonio Vargas and wins WBA bantamweight title. Bam is rolling and is one of the best in the sport. Now, will he get the mega-fight with Naoya Inoue next or not? The guys go over everything. Then, some newsAnnouncement during the Saturday Matchroom card that super middleweight Diego Pacheco will headline against Immanuwel Aleem on July 26 at the Dignity Health Sports Park in Carson, California. Andy Cruz vs. Albert Bell IBF lightweight eliminator in the co-feature.  No is done yet, but PBC is working to make WBA junior welterweight titlist Gary Antuanne Russell to make his second defense against Isaac “Pitbull” Cruz (the WBC interim titlist) in late August or September.  Heavyweight Moses Itauma's summer date has been moved to Aug. 29 in London but the hunt is still on for an opponent as Filip Hrgovic has turned down the fight for August. T.J. wonders on all levels WHAT ARE WE DOING HERE with Itauma, who needs rounds and credibility not fighting more regularly.Next, talks are going on for a mandatory fight between WBA lightweight titlist Gervonta "Tank" Davis and Floyd Schofield. How realistic is this for either of them.Opponents set for Edgar Berlanga and Richardson Hitchins on Zuffa Boxing's NYC debut card July 26 at Madison Square Garden Theater. Berlanga will take on two-time middleweight title challenger Steven Butler and Hitchins, moving up to welterweight, will face Ricardo Salas. Dan has more on the matchups.It's all part of the "Fight Freaks Unite Recap Podcast" and make sure to follow/subscribe on Apple/Spreaker/Spotify, etc.! 

In the Bible Profile series, I look at Jacob, one of the twin sons of Isaac. His life was much more dramatic than his father’s. In this message, I consider Jacob’s lies, his ladder, his Lord and his loss. Jacob

Pull up a chair because this solo episode is serving all the behind-the-scenes tea on what's really happening at Pivot Ball Change. From clients we've said goodbye to (and the lessons learned along the way) to exciting new additions to the roster, this quarterly business report breaks down the current state of PBC with total transparency. You'll also get a peek into how the work schedule is shifting for summer, what's being delegated, and how the 4 F's are shaping life and business right now.Key Topics Covered:Why one client turned into a two-episode "one and done" and how to spot short-term vs. long-term client relationships early on.How the client selection process has evolved and why there's more room to be selective now than in the early days of the business.The story behind losing a long-standing launch client and the direction their show decided to go.A roundup of all the new podcast clients, what their shows are about, and what the editing and production process looks like for each.How one client funds their podcast editing through grant money.The simplest (and most affordable) production package offered, coming in at just $20 per episode.What makes a dream client and which type is the absolute favorite to work with.Summer schedule shifts, childcare realities, and how work hours and tasks are being restructured.The 4 F's: Fiction, Fun, Fashion, and Fitness, and how they're all connecting this season.Links & Resources:Healthier, Happier, Smarter Podcast: https://podcasts.apple.com/us/podcast/healthier-happier-smarter-wisconsin-voices-on-the/id1886495272?l=zh-Hant-TWListen to Elena's Episode Here: https://www.pivotballchange.com/podcast-1/70Listen to Shannon's Episode Here: https://www.pivotballchange.com/podcast-1/66The Slow Living Era Podcast: https://podcasts.apple.com/us/podcast/the-slow-living-era-moving-motherhood-and-building/id1896558785Nourish Move Love Workouts: https://www.instagram.com/nourishmovelove/Smash Burgers: https://grumpyrecipes.com/smash-burgers/?utm_source=Pinterest&utm_medium=organicLet's Connect!Book Your Podcast Consultation Today: https://www.pivotballchange.com/servicesLaunch Your Podcast with Pivot Ball Change: https://www.pivotballchange.com/servicesFollow Pivot Ball Change on Instagram: https://www.instagram.com/pivotballchange/Visit Pivot Ball Change's Website: https://www.pivotballchange.com/Riverside: https://riverside.sjv.io/c/6950782/2183832/28064

Good morning from Pharma Daily: the podcast that brings you the most important developments in the pharmaceutical and biotech world. Today, we dive into a series of groundbreaking advancements and strategic maneuvers reshaping the landscape of drug development and patient care. In recent news, Moderna and Merck & Co. have reported substantial progress in cancer treatment with their Phase 2b trial results involving Intismeran Autogene combined with Keytruda. This combination therapy, leveraging the innovative mRNA vaccine technology alongside Keytruda, has shown a remarkable 49% reduction in recurrence risk for high-risk melanoma patients. This synergy not only enhances therapeutic options in melanoma but also underscores the transformative potential of mRNA vaccines beyond infectious diseases, suggesting a new frontier for oncology treatments. Bristol Myers Squibb has also made significant strides with its Phase 3 trial results for Izalontamab Brengitecan, an antibody-drug conjugate. This therapy has demonstrated a 40% reduction in death risk among patients with triple-negative breast cancer—an aggressive subtype with historically limited treatment options. The success of this bispecific antibody targeting Trop2 highlights the advancing trend towards precision medicine, where therapies are increasingly tailored to specific genetic and molecular profiles, promising improved patient outcomes. Turning to business developments, Rallybio's merger with Avenzo Therapeutics through a reverse merger transaction marks a notable consolidation trend within the industry. Supported by a $215 million private placement, this merger aims to accelerate drug discovery and development in oncology, emphasizing the importance of strategic collaborations in enhancing therapeutic pipelines. Similarly, MindMaze Therapeutics is streamlining operations post-merger by refocusing on core competencies aligned with broader industry trends towards specialization. Regulatory updates have been equally dynamic. Shionogi's Xocova (Ensitrelvir) has received FDA approval for post-exposure prophylaxis against COVID-19 following successful Phase 3 trials. As a small-molecule protease inhibitor, Xocova enriches the therapeutic arsenal against COVID-19 and reflects ongoing efforts to manage infectious diseases even as the pandemic wanes. Strategic partnerships are further shaping the industry landscape. The collaboration between ASCO and Ryght AI aims to enhance breast cancer trial site selection using artificial intelligence. This initiative signifies a growing trend towards integrating AI and machine learning technologies in clinical trial optimization to streamline processes and improve efficiency—an essential endeavor as trials become more complex and data-driven. Additionally, Sanofi's integration of AI via field agents to enhance efficiencies across business facets highlights how AI adoption is accelerating and promises to reshape drug development processes and patient care strategies significantly. Meanwhile, challenges persist. The FDA's rejection of Cingulate's CTX-1301 due to manufacturing concerns underscores the rigorous regulatory environment that companies navigate. Similarly, Roche's Persevera trial missing its primary endpoint in breast cancer treatment highlights the inherent risks involved in drug development. In scientific advancements, Gilead Sciences has made progress with Livdelzi in treating primary biliary cholangitis (PBC), a rare liver disease. The Phase 3 trial success points to ongoing innovation in rare disease treatments—a critical area for enhancing patient outcomes. On another front, Contraline is advancing its male birth control candidate after securing $92.5 million in funding. This first-in-class topical contraceptive fills a significant gap in male contraceptive options, demonstrating an increasing focus on diversifying reproductive health solutions. In strategic shifts within the industry, Merck is reducing its workforce as part of a broader $3 billion cost-cutting strategy aimed at optimizing operations while investing in innovation and technology. At ASCO 2026, Celcuity shared ambitions to revolutionize breast cancer treatment paradigms through innovative pathway targeting, while GSK introduced a new approach for rare gut cancers—conditions that have seen little advancement over decades. Such initiatives highlight critical roles innovative research plays in oncology. In summary, these developments reflect a vibrant period for the pharmaceutical and biotech sectors characterized by scientific innovation, strategic mergers, regulatory milestones, and ongoing clinical trials that collectively promise to enhance patient care. Emphasis on personalized medicine, expansion of mRNA technology into oncology, and AI-driven efficiencies are poised to redefine approaches across therapeutic domains while navigating stringent regulatory standards and market dynamics that require strategic agility and robust R&D pipelines. Thank you for tuning into Pharma Daily—your source for insightful updates from the world of pharmaceuticals and biotechnology. Stay connected for more groundbreaking news and analysis shaping the future of healthcare.Support the show

What Are You Waiting For? - Revelation 21 - 22:5 Kyle Walker

In this message from the book of James, I look at how we are taught to judge not and grudge not one another. If we as Christians would apply this simple teaching, it would enrich our lives toward the Lord and one another. 05.17.26.Judge.Not.Grudge.Not.Tim.McCool

The Learning Leader Show with Ryan Hawk Read my NEW BOOK -- The Price of Becoming -  www.LearningLeader.com/Becoming Eric Ries is the author of The Lean Startup, one of the most influential business books of the past 25 years, and the founder of the Long-Term Stock Exchange, the first new U.S. exchange to both list and trade multiple stocks since NASDAQ launched 50 years ago. His new book is Incorruptible. Key Learnings The more successful a company becomes, the more valuable it is as a target. Companies are worth stealing and taking over. Most founders are naive about this and don't understand what's coming for them. They've been following the so-called best practices about how companies should be built, structured, and governed. Most of those best practices are value-destroying. Sol Price was a lawyer before he became an entrepreneur. He believed a lawyer had a fiduciary duty to put the client's interests before his own. So when he became a retailer, he asked: "Who's my client?" The customer. He treated the customer as the person he would rather die than betray. When competitors sold a product for less, he'd put up signs in his own store: "Don't buy this from me. You can get it cheaper somewhere else." He capped his margins at 14 percent. He paid above-market wages. It is so much easier to destroy than to create. One day, Sol came into work and couldn't get into his office because the locks had been changed. Investors had pushed him out and forced Fedmart to practice retail best practices. Within seven years, they bankrupted the company. We've built an economy that rewards people for cost-cutting without holding them accountable for the consequences to trustworthiness, brand, or culture. The origin story of Costco: Sol took two weeks off, then leased the office upstairs from Fedmart and started Price Club. One of the young guys who left with him, Jim Sinegal, had worked his way up from stock boy. Jim eventually started his own company using the Sol ethos. A few years later, their companies merged to form what we now call Costco. Wall Street routinely calls Costco the exception to every rule. Wall Street analysts say things like: "At Costco, they take money that rightfully belongs to shareholders and instead invest it in the customer experience." As if that's a criticism. Costco endures because it's protected by a governance fortress. A series of worst practices that resist outside pressure structurally. The $1.50 hot dog has been the same price since 1986. A McDonald's Big Mac was $1.60 in 1986. Today that same Big Mac in California is over $7. Costco sells more hot dogs than every Major League Baseball stadium in America combined. If they raised the combo to $7, it would be a billion dollars of extra net income. They could do it. They choose not to. "If you raise the price of the effing hot dog, I will kill you. So figure it out." Jim Sinegal said it to his COO in 2008 when costs were rising. Figure it out. Costco vertically integrated the hot dog supply chain. They own hot dog production plants in multiple cities. They worked deals with soda vendors. They did all that extra work for the privilege of not making more money on the hot dog. Harder is easier. "When you take the hard road, when you make a principled commitment, you get these almost unbelievable values. Because you're generating the most underrated and most valuable asset in all of business: trustworthiness." "Easy choices, hard life. Hard choices, easy life." Jerzy Gregorek, Olympic weightlifter. "Everybody wanna be a bodybuilder. Nobody wanna lift these heavy ass weights." Ronnie Coleman, eight-time Mr. Olympia. Everyone wants the outcome. Nobody wants to do the actual thing. Culture and mission can be cultivated, not commanded. Most leaders get this wrong. They say "I'm in charge of my team." But can you command your team to have integrity? Can you command it to have a particular culture? You have to make consistent, responsible choices, just like cultivating health in your body. Get reps. Eric gave practice talks at a Hobee's restaurant at 7 AM to six people just to get the reps. Caring and trying to do a good job is so unbelievably rare. That alone is a competitive advantage. Feedback tells you something about the person giving it, not about yourself. If someone reads Eric's manuscript and says, "This book sucks," he hasn't learned anything about the book. He's learned this person doesn't like this kind of book. When he stopped arguing with negative customer reviews and started studying who they came from, he noticed patterns. People 16 and younger loved the product. People 16 and older hated it. He learned who his product was for. Separate qualitative from quantitative feedback. Qualitative is for hypothesis generation. Quantitative is for hypothesis validation. When test readers told him a chapter wasn't working, that was qualitative. When the platform data showed nobody was getting past that chapter, that was quantitative. You need both to know what to fix. It is always too early until it's too late. Eric tells the story of a multibillion-dollar founder he warned before his IPO. The founder talked to his bankers, lawyers, and CFO. They told him Eric was a downer. The founder went public anyway with conventional governance. Five months later, his stock dropped 90 percent, and he was ousted. The best time to plant a tree is 40 years ago. The second-best time is today. Eric's checklist for building an incorruptible company: Encode your mission into the corporate charter. Most founders have never read their charter. If your mission statement says one thing but your legal charter says another, you're lying. The easiest fix: file a public benefit corp filing (PBC). Two pages. 44 states. Your lawyer can do it tomorrow. Identify your fiduciary commitments. Who would you rather die than betray? Is it your customers? Your employees? Product quality? You decide. If your answer is nobody, you're a sociopath. The whole book is for the people who actually want to accomplish something. Align your employees to that mission. Make sure everybody on the team is committed to the same fiduciary priority. Create a director's oath. Like the Hippocratic Oath for doctors, but for your board. They must pledge to commit to the company's mission. Board betrayal and investor pressure are leading causes of death of companies in the modern world. Make the directors accountable to somebody. Power without accountability is corrosive to the human spirit. Novo Nordisk is governed by a nonprofit foundation. Patagonia is governed by a perpetual purpose trust. John Lewis Partnership in the UK is governed by an employee ownership trust. IKEA, Vanguard, and REI all have these structures. The data shows these companies are dramatically more stable and higher performing than conventional structures. You are not stuck in traffic. You are traffic. People love to blame the system. But you're not just a passenger. You're part of what creates the system. Where you work. What you buy. What you give your attention to. Every one of those choices is fueling somebody's company, somebody's algorithm, somebody's bonus. The richest people in the world spend billions on PR because they know your individual choices matter. Use that power. Eric's champagne moment a year from now: a grassroots movement around Incorruptible. This book won't get wall-to-wall media coverage. It's antagonistic to people in power. So Eric hopes readers will hand it to their founders, their bosses, their friends. If consumers and employees start demanding, "I want to work in an incorruptible company," that's the toast. Reflection Questions What is your equivalent of Costco's hot dog? The one commitment you'd defend even when it's financially painful, even when the easy move would be to abandon it? Have you ever read your corporate charter, or the foundational document of your team or department? Does what's actually written match what you say you stand for? Where in your work or life would the harder short-term path build something more durable in the long run? Are you willing to lift the heavy weights? More Learning #258: Jesse Itzler: Creating Your Life Resume & Living Outside the Box #529: James Clear: Setting Up Your Future Self & Becoming an Optimist #565: Noah Kahan: The Art of Asking For What You Want Podcast Chapters 00:00 The Price of Becoming - Pre-Order Now!  01:03 Meet Eric Ries  02:55 Is It Possible to Build an Incorruptible Company?  04:04 Why Culture Alone Won't Save You  05:13 Sol Price, Fedmart, and the Locks That Got Changed  07:56 Why Wall Street Calls Costco the Exception  09:11 The $1.50 Hot Dog Story  13:59 Harder Is Easier: The Principle Behind It All  16:48 Why Governance Is Just Soul Craft  19:50 Building the First New Stock Exchange Since Nasdaq  22:33 Eric's Communication Style: Reps, Not Talent  30:52 The Opportunity Hiding in Broken Markets  31:59 How to Know Which Feedback to Listen To  35:39 Qualitative vs. Quantitative: Why You Need Both  37:23 The Whole Foods Cautionary Tale  40:25 The Founder's Checklist for Building Something Durable  43:44 Encode Your Mission Into the Corporate Charter  47:35 You Are Not Stuck in Traffic. You Are the Traffic.  52:37 The Champagne Question: A Grassroots Movement  55:27 James Clear, Author's Equity, and the Future of Publishing 56:43 EOPC

The God of History - Ezra 1 - 2 Cory Varden

When someone is in darkness, light brings vision and hope. Jesus’ ministry was a “great light” in a very dark place. Not only from a spiritual standpoint, but the actual region into which Jesus carried out most of his public ministry, was known for great darkness. In this message, I look at the great Light …

It is not unusual for a child to fantasize about being a superhero. The idea of flying or having super strength appeals to the imagination. Have you ever thought about what it would have been like to be Jesus? To have the ability to heal the sick, raise the dead, walk on water, and turn …

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Assurance and Its Fruits - 1 John 5: 13-21 Ryan Adams

It is easy to provoke people to anger or to provoke someone to become upset. But is altogether another activity to provoke others to love and to good works. In this message in the one anothering series, I look at this important subject. 05.03.26.Consider.One.Another.Tim.McCool

Whether it’s painting the Sistine Chapel, carving the faces of Mount Rushmore, or playing the piano, the hands of men are capable of incredible things. As impressive as they are, men’s hands can’t touch what the hands of Christ did. From the healing touch given to the leper, to holding our eternal salvation secure, truly …

Here is the first message from our recent annual meeting. Lic. Jonah Lowrance shares a wonderful opening message at the meeting. We can say what we think about God’s word and although it may be true, it might not carry a lot of weight. But in this sermon, Brother Jonah shares what Jesus Himself said …

In the 2nd message of the annual meeting, Elder Michael Hattaway looks at two questions, both found in Matthew 16. Jesus asked, “Whom do men say that I am?” And then he asked the apostles – “Whom do you say that I am?” 05.02.26.Msg.2.Two.Questions.Jesus.Asked.Michael.Hattaway

In the afternoon service of the annual meeting, Brother Jonah Lowrance presents a message from Paul’s final letter, written before he died. 05.02.26.Msg.3.Pauls.Final.Letter.Jonah.Lowrance

In the final message of the day, Elder Michael Hattaway preaches from Revelation 19, focusing on the truth that is proclaimed in heaven – The Lord God omnipotent reigneth. 05.02.26.Msg.4.The.Lord.God.Omnipotent.Reigneth.Michael.Hattaway

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Ryan Adamsfalse

Practically everyone has a cell phone. And those who do not are wishing they did. The original Greek word for “voice” is the word we have today as “phone.” In that sense, Christ has a phone (Voice) that is an irresistible call. In this message I look at the cell phone call of Christ. 04.26.26.Jesus.Cell.Phone.Tim.McCool

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Most of us have seen a video with the caption POV. That caption is telling us to frame our minds to see something from a certain point of view. How often do we look at situations in life from God’s point of view? Oftentimes in the Bible we find good, well meaning people having the …

Have you ever compared your disobedient thoughts to a criminal on the run? In the same way a criminal must be overpowered, apprehended, and taken into captivity…so must our sinful thoughts. Every wicked deed begins with a wicked thought. In this sermon Brother Luke looks at what the Bible says about taking our thoughts captive. …

Today I am sharing with you the latest message in the “One Anothering” series. To love one another as Christ loved His people is the goal of discipleship. It identifies God’s children. And the NT is filled with specific ways we are to love one another. In this message, I look at increasing, abounding and …

In the “One Anothering” series, I look at what might be the most important of the loving one anothers – be kind, tenderhearted and forgiving. I wonder how much revival our churches would experience if we daily loved one another in this way. 04.12.26.Kind.Tenderhearted.and.Forgiving.Tim.McCool

The Bible describes our life on the earth as leaves that fade or grass that withers. In the same way that plants change with the season, so do our lives as time marches forward. We start as young tender leaves in the spring of life and quickly find ourselves in the winter season, where strength …