Podcasts about PBC

How do you decide when to move from first-line to second-line treatment for primary biliary cholangitis (PBC)? In this podcast, listen as experts Alan Bonder, MD, AGAF, and Aparna Goel, MD, discuss this question and more, including:How and when to measure treatment responseEvidence-based goals of therapyConsiderations for second-line treatmentNew agents for second-line treatment: PPAR agonistsPresenters:Alan Bonder, MD, AGAFAssociate Professor of MedicineMedical Director of Liver TransplantDepartment of GastroenterologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBoston, MassachusettsAparna Goel, MDAssociate Clinical Professor of MedicineDivision of Gastroenterology and HepatologyStanford UniversityPalo Alto, CaliforniaContent based on an online CME program supported by independent educational grants from Gilead Sciences, Inc., and Ipsen Biopharmaceuticals, Inc​.To learn more about PBC management, check out our program, Curbside Consults: Expert Insights on Challenges in PBC Management.Supported by educational grants from Gilead Sciences, Inc. and Ipsen Biopharmaceuticals, Inc

In this podcast, listen as experts Alan Bonder, MD, AGAF, and Aparna Goel, MD, discuss how they assess the symptoms of primary biliary cholangitis (PBC) and explore how new therapeutic agents may help alleviate symptom burden. Topics include:Strategies and tools for assessing pruritusNonpharmacologic and pharmacologic management of pruritusSecond-line agents and their impact on pruritusInvestigational treatments for pruritusPresenters:Alan Bonder, MD, AGAFAssociate Professor of MedicineMedical Director of Liver TransplantDepartment of GastroenterologyBeth Israel Deaconess Medical CenterHarvard Medical SchoolBoston, MassachusettsAparna Goel, MDAssociate Clinical Professor of MedicineDivision of Gastroenterology and HepatologyStanford UniversityPalo Alto, CaliforniaContent based on an online CME program supported by independent educational grants from Gilead Sciences, Inc., and Ipsen Biopharmaceuticals, Inc​.To learn more about PBC management, check out our program, Curbside Consults: Expert Insights on Challenges in PBC Management.

Are women being sold a myth about fitness during menopause? Michelle MacDonald sits down with Dr. Allan Bacon—a former surgeon turned physique coach—for a frank, science-backed conversation on women's health and fitness, the damaging fads targeting midlife women, and the importance of cultivating a healthy mindset over quick fixes. They explore the psychological traps of crash diets, the false promises of hormone-focused programs, and the influence of social media pseudoscience. Dr. Bacon breaks down how personal growth comes from evidence-based training, not magical shortcuts, and offers empowering truths about body composition, strength training, and navigating menopause with resilience and logic.Leave a rating for this podcast with one click https://ratethispodcast.com/michellemacdonald  WHAT TO LISTEN FOR0:38 Why Smart Women Fall for Fitness Fads3:14 Menopause Marketing A Feeding Frenzy11:44 Just Lift Heavy The Most Misleading Advice13:29 Do Men and Women Build Muscle the Same20:32 Age-Related Muscle Loss What's Really Happening28:22 Women Are Not Large Mice32:39 The SWAN Study Hope for Midlife Women GUEST: DR. ALLAN BACON, DDS, CPT, PBC, USAPL-CC, CNC, PN1Website | Instagram | YouTube | Facebook GroupCONNECT WITH MICHELLEWebsite | Instagram | YouTube | Facebook | X

Matt and EzRaw discuss the latest in boxing news including:News and NotesOscar De La Hoya says the media is bought and paid for and won't write and talk about certain newsOscar De La Hoya says Eddy Reynoso needs to be investigated?Oscar De La Hoya says Canelo vs Crawford will be during the day and not in prime timeOscar De Hoya states Golden Boy, PBC, and Matchroom are all working together to make fights and are not going anywhereTeofimo Lopez wears a PBC hat on his Instagram story with the date 8-16Turki Alasheik states he doesn't want anymore Tom and Jerry fightsJake Paul states he thinks Anthony Joshua, Ryan Garcia, and Canelo Alvarez are the most overrated boxersEddie Hearn says Turki does all the promotional ideas for his events and everyone else takes a back seatEZ Money Parlay of the Day, EzRaw Report Card, EzRaw BreakdownEzRaw BreakdownHitchins vs Kambosos Wardley vsHuni Mason vsNakathaliaEzra's Raw Hard CashMike's EZ moneyMatt's Best Bet.Rumor ReportQuick HitsOscar “La Migraña” Duarte vs. Kenneth “Bossman” Sims Jr. 8/2/25.Nonito Donaire return tonight vs Andres Compos -Souleymane Cissokho has officially been named the mandatory challenger to the winner of the July 19, PBC PPV on Prime bout between Mario Barrios and Manny Pacquiao.The winners of Rey Vargas vs. Carlos Castro and Bruce Carrington vs. Mateus Heita must fight each other afterThe WBC will order a bout between Interim WBC Junior Middleweight Champion Vergil Ortiz and Serhii Bohachuk. Ortiz previously defeated Bohachuk in August 2024.Edwin De Los Santos and Sampson Lewkowicz have agreed to mutually part waysFilip Hrgovic vs. David Adeleye 8/16 in SaudiThe WBO has officially ordered negotiations between Sam Noakes and Abdullah Mason for the vacant WBO Lightweight Championship. Parties have 20 days to reach agreement.Alan David Picasso vs. Kyonosuke Kameda on July 19 at the MGM Grand Garden Arena in Las Vegas as part of #PacquiaoBarriosKenshiro Teraji vs. Ricardo Sandoval, Antonio Vargas vs. Daigo Higa, Erick Rosa vs. Kyosuke Takami#MrOneTake's One TakeRead the latest news at Brunch BoxingThoughts or questions? Email us at brunchboxingqa@gmail.comHosts: Matt, and EzRawSocial: MikeProducer: Huey

Ryan Adamsfalse

Uuden pelikonsolin julkaisu on aina juhlan aikaa, mutta uuden PBC-jakson julkaisu onnistuu pilaamaan nämäkin juhlat. Uusimmassa jaksossa, viimeisessä ennen juhannustaukoa, kuulet juttua Switch 2:sta ja sen julkaisupeli Mario Kart Worldista. Tämän jakson jälkeen tosiaan apinalauma pitää pienen juhannustauon ja jos ei jokainen meistä huku, tulee uutta jaksoa taas ulos heinäkuun puolella. Kiitos ja anteeksi. (00:46:12) Uutiset: […]

It is easy to lose heart in the face of evil. Sometimes the evil that affects us can be distant – like being frustrated with politics. But sometimes it touches us directly. When it touches us directly, we need to prepare our minds to know how the Lord views and deals with such evil, as …

(0:00) Intro (1:49) About the podcast sponsor: The American College of Governance Counsel(2:36) Introduction by Professor Anat Admati, Stanford Graduate School of Business. Read the event coverage from Stanford's CASI.(4:14) Start of Interview(4:45) What inspired Karen to write this book and how she got started with journalism.(8:00) OpenAI's Nonprofit Origin Story(8:45) Sam Altman and Elon Musk's Collaboration(10:39) The Shift to For-Profit(12:12) On the original split between Musk and Altman over control of OpenAI(14:36) The Concept of AI Empires(18:04) About concept of "benefit to humanity" and OpenAI's mission "to ensure that AGI benefits all of humanity"(20:30) On Sam Altman's Ouster and OpenAI's Boardroom Drama (Nov 2023) "Doomers vs Boomers"(26:05) Investor Dynamics Post-Ouster of Sam Altman(28:21) Prominent Departures from OpenAI (ie Elon Musk, Dario Amodei, Ilya Sutskever, Mira Murati, etc)(30:55) The Geopolitics of AI: U.S. vs. China(32:37) The "What about China" Card used by US companies to ward off regulation.(34:26) "Scaling at All Costs is not leading us in a good place"(36:46) Karen's preference on ethical AI development "I really want there to be more participatory AI development. And I think about the full supply chain of AI development when I say that."(39:53) Her biggest hope and fear for the future "the greatest threat of these AI empires is the erosion of democracy."(43:34) The case of Chilean Community Activism and Empowerment(47:20) Recreating human intelligence and the example of Joseph Weizenbaum, MIT (Computer Power and Human Reason, 1976)(51:15) OpenAI's current AI research capabilities: "I think it's asymptotic because they have started tapping out of their scaling paradigm"(53:26) The state (and importance of) open source development of AI. "We need things to be more open"(55:08) The Bill Gates demo on chatGPT acing the AP Biology test.(58:54) Funding academic AI research and the public policy question on the role of Government.(1:01:11) Recommendations for Startups and UniversitiesKaren Hao is the author of Empire of AI (Penguin Press, May 2025) and an award-winning journalist covering the intersections of AI & society. You can follow Evan on social media at:X: @evanepsteinLinkedIn: https://www.linkedin.com/in/epsteinevan/ Substack: https://evanepstein.substack.com/__To support this podcast you can join as a subscriber of the Boardroom Governance Newsletter at https://evanepstein.substack.com/__Music/Soundtrack (found via Free Music Archive): Seeing The Future by Dexter Britain is licensed under a Attribution-Noncommercial-Share Alike 3.0 United States License

• ¡Ya es oficial canelo – Crawford pelearan el 13de septiembre en las vegas, así lo confirmó el tio turki!• A un mes de su regreso al boxeo profesional Manny Pacquiao es inducido al salón de la fama del boxeo…• En exclusiva el pac man nos abrió las puertas de su campamento…• A horas de conocer el resultado de la prueba “B” Mauricio Sulaiman presidente del cmb apoya a Jaime Munguia…• ¡Tras sy retiro recordaremos los mejores momentos de la carrera de Vasily Lomachenko!

#teofimolopez #gervontadavis #premierboxingchampions ThaBoxingVoice dives into the sizzling rumor: Has Teofimo Lopez Jr., the WBO junior welterweight champ, signed with Premier Boxing Champions? We unpack the buzz from X posts, including Lopez's PBC hat video with the '8.16' date, his plan to fight the Davis-Roach winner, and a fan's backlash over his racist remarks. Is this a new era for “The Takeover,” or just hype? Join us as we debate Lopez's next move, analyze his Times Square win, and explore PBC's stance. With exclusive insights, fan polls, and spicy takes, this episode is a must-listen for boxing fans craving the latest on this polarizing star. Tune in, vote, and let your voice be heard!

In this message, I look at the prayer of true pastors – that the people he preaches to will stand in the truths they are taught. 06.01.25.A.Pastors.Prayer.Tim.McCool.mp3

Corey Irbyfalse

#mannypacquiao #mariobarrios #premierboxingchampions Step into the ring with ThaBoxingVoice as we unpack the potential collapse of Premier Boxing Champions (PBC) with their Amazon Prime Video deal on the ropes. Why is PBC's PPV-heavy model driving fans away? With ESPN out after parting with Top Rank, and Netflix and Riyadh Season stealing the spotlight, what's next for stars like Gervonta “Tank” Davis? Joined by boxing insider Blake Avignon, we break down recent bouts, financial rumors, and boxing's shifting streaming landscape. Expect unfiltered takes, fan polls, and bold predictions on whether PBC can dodge a knockout. A must-listen for boxing fans craving the truth behind this pivotal moment! Subscribe now!

Everyone is looking for happiness. Being happy is a wonderful way to feel. But the reality of life is that happiness can be difficult to achieve and more difficult to hang onto. In this message, I look at how to find happiness in the context of Peter’s clear teaching on discipleship. 05.28.25.How.to.Find.Happiness.Tim.McCool

• ¡EDDY REYNOSO SOLO ENTRENA A MUNGUIA, EL NO ES RESPONSABLE MAS QUE, DE LO DEPORTIVO, SAUL ALVAREZ• ¡ARMANDO RESENDUZ DA LA CAMPANADA Y SE CORONA CAMPEON INTERINO EN 168 LIBRAS!• ¡MANNY PACQUIAO Y MARIO BARRIOS PRESENTARON SU PELEA EN ESTADOS UNIDOS!• HABRA REVANCHA ENTRE NAVARRETE Y CHARLY SUAREZ!• PITBILL CRUZ VS TASHIRO FIERRO PARA EL 19 DE JULIO• ¡A NUEVE AÑOS DE SU PARTIDA, RECORDAREMOS LA VIDA DE MUHAMMAD ALI!

Jesus tells us that in order for a man to find his life he must first lose it. That might seem like an unusual statement if we only look at it from a superficial perspective. In this sermon, Brother Luke looks at the life of Paul to get a better understanding of what it means …

Erin Blanchfield learned minutes before walkouts that Maycee Barber dropped out of the UFC Vegas 107 main event. LT and BC go over the circumstances regarding the last-minute cancellation and what this means for Barber's future. Also, what is next for Blanchfield? The fellas go over the rest of the card including Mateusz Gamrot's impressive win against Ludovit Klein. And Ramiz Brahimaj and Dustin Jacoby both notched first-round wins. Plus, the guys go over the results from the PBC card, news about a location change for Noche UFC and a look at this weekend's UFC 316 event.See omnystudio.com/listener for privacy information.

#PlantResendiz #CharloLaManna #calebplant On this explosive episode of #TBVPodcast, Thaboxingvoice dives into the May 31, 2025, PBC on Prime Video card from Las Vegas! We break down Caleb Plant defending his WBA interim super middleweight title against Armando Resendiz in a 12-round clash. Jermall Charlo returns against Thomas LaManna in a 10-round super middleweight bout, setting up a potential Plant showdown. Plus, we preview Yoenli Feliciano Hernandez vs. Kyrone Davis and Isaac Lucero vs. Omar Valenzuela. Join us for expert analysis, bold predictions, and the latest boxing buzz!

In the series from I Thessalonians, I look at a statement made by the Apostle Paul. He says that the church at Thessalonica was appointed to afflictions. When we are in the fire of afflictions, the heat shows what is in our heart. In this message, I look at how we face affliction and how …

Everyone agrees that the plant you grow will always be the same as the seed you plant. Corn seeds don’t yield apple trees. The Bible is clear that we will reap what we sow. If we sow to the flesh we will reap destruction. Our problem as children of God is not a lack of understanding this, but it comes …

Another weekend and another shocker main event, as Caleb Plant was upset in Las Vegas. We discuss that bout, the undercard and also fight cards for Golden Boy Promotions and Matchroom Boxing from Friday on the latest "Fight Freaks Unite Recap Podcast."Host T.J. Rives and insider Dan Rafael of his Fight Feaks Unite Substack and newsletter are back.The discuss.The PBC on Prime Video card Saturday in Las Vegasas little known Armando Resendiz upset Caleb Plant and wins the WBA interim 168 lb. title. Is this more verifcation that Plant's better days are behind him? And what does it do to the possible fight with super middleweight Jermall Charlo, who scored a TKO6 over Thomas "Cornflake" LaManna.They also talk the middleweight Yoenli Hernandez decisioning Kyrone Davis and also, junior middleweight Isaac Lucero with a quick TKO over Omar Valenzuela. Next a recap of the Golden Boy DAZN main event Friday in Las VegasSuper middleweight Bektemir Melikuziev wins a tremendous decision over Darius Fulghum in a WBA eliminator. More on this bout.Plus, there was a solid Matchroom DAZN card Friday in Guadalajara, MexicoLight heavyweight Khalil Coe TKO6 over Manuel Gallegos in a rematch and avenges his TKO loss. And, junior featherweight Murodjon Akhmadaliev earns a TKO8 against Luis Castillo and up next is Sept. 14 Naoa Inoue challenge for the undisputed 122 lb. belts.Some NewsDevin Haney-Teofimo Lopez back ON for Aug. 16th after Teofimo apologized to Turki Alashikh.The Manny Pacquiao-Mario Barrios full PPV undercard wsa announced Saturday in Vegas and the fighters met briefly with the media.Sadly, Hall of Famer Mike McCallum died in Las Vegas at age 68. One of the greats! He won titles at 154 lb., 160 lb., and 175 lb. We reminisceNostalgiaJune 1, 2019 – 6 years ago Sunday – late replacement opponent Andy Ruiz TKO7 Anthony Joshua in a massive upset to win the unified WBO/IBF/WBA heavyweight title in their first fight. Big Dan ringside at MSG. (Watch more on this huge upset on our Big Fight Weekend Youtube page)Hear it all on the "Fight Freaks Unite Recap Podcast" and make sure to follow/subscribe on Apple/Spreaker/Spotify, etc.!

Instant Reaction to Armando Resendiz' split decision win over Caleb Plant t win the WBA Super Middleweight Title. Plus a full breakdown on the PBC on Prime card.#ArmandoResendiz #plantreséndiz@toro_resendiz1 @premierboxing

Another weekend and another shocker main event, as Caleb Plant was upset in Las Vegas. We discuss that bout, the undercard and also fight cards for Golden Boy Promotions and Matchroom Boxing from Friday on the latest "Fight Freaks Unite Recap Podcast."Host T.J. Rives and insider Dan Rafael of his Fight Feaks Unite Substack and newsletter are back.The discuss.The PBC on Prime Video card Saturday in Las Vegasas little known Armando Resendiz upset Caleb Plant and wins the WBA interim 168 lb. title. Is this more verifcation that Plant's better days are behind him? And what does it do to the possible fight with super middleweight Jermall Charlo, who scored a TKO6 over Thomas "Cornflake" LaManna.They also talk the middleweight Yoenli Hernandez decisioning Kyrone Davis and also, junior middleweight Isaac Lucero with a quick TKO over Omar Valenzuela. Next a recap of the Golden Boy DAZN main event Friday in Las VegasSuper middleweight Bektemir Melikuziev wins a tremendous decision over Darius Fulghum in a WBA eliminator. More on this bout.Plus, there was a solid Matchroom DAZN card Friday in Guadalajara, MexicoLight heavyweight Khalil Coe TKO6 over Manuel Gallegos in a rematch and avenges his TKO loss. And, junior featherweight Murodjon Akhmadaliev earns a TKO8 against Luis Castillo and up next is Sept. 14 Naoa Inoue challenge for the undisputed 122 lb. belts.Some NewsDevin Haney-Teofimo Lopez back ON for Aug. 16th after Teofimo apologized to Turki Alashikh.The Manny Pacquiao-Mario Barrios full PPV undercard wsa announced Saturday in Vegas and the fighters met briefly with the media.Sadly, Hall of Famer Mike McCallum died in Las Vegas at age 68. One of the greats! He won titles at 154 lb., 160 lb., and 175 lb. We reminisceNostalgiaJune 1, 2019 – 6 years ago Sunday – late replacement opponent Andy Ruiz TKO7 Anthony Joshua in a massive upset to win the unified WBO/IBF/WBA heavyweight title in their first fight. Big Dan ringside at MSG. (Watch more on this huge upset on our Big Fight Weekend Youtube page)Hear it all on the "Fight Freaks Unite Recap Podcast" and make sure to follow/subscribe on Apple/Spreaker/Spotify, etc.!

Dr. John Sweetenham shares highlights from Day 3 of the 2025 ASCO Annual Meeting, including new research for the treatment of advanced renal cell carcinoma and 2 studies on novel approaches in non-small cell lung cancer. Transcript Dr. John Sweetenham: Hello, I'm Dr. John Sweetenham, the host of the ASCO Daily News Podcast, with my takeaways on selected abstracts from Day 3 of the 2025 ASCO Annual Meeting. Today's selection features studies addressing the treatment of advanced renal cell carcinoma and 2 studies exploring novel approaches in non-small cell lung cancer. My disclosures are available in the transcript of this episode. The first abstract is number 4505. This study, led by Dr. Toni Choueiri of the Dana-Farber Cancer Institute, describes the final analysis of the CheckMate 214 trial, which compared the combination of nivolumab and ipilimumab with sunitinib for the first-line treatment of advanced renal cell carcinoma. The ipi-nivo combination is approved for the frontline treatment of intermediate and poor-risk advanced renal cell carcinoma based on the primary analysis of the CheckMate 214 trial, which demonstrated a higher response rate and longer overall survival compared with sunitinib. Today's presentation provided the final safety and efficacy results for the trial with long-term follow-up of more than 9 years.  The intent-to-treat (ITT) population in this trial comprised 550 patients randomized to nivo and ipi versus 546 who received sunitinib. The final analysis showed sustained long-term benefit for the combination therapy. Patients given nivolumab plus ipi had a 29% reduction in the risk for death compared with sunitinib. For patients with intermediate or poor-risk disease, there was a 31% reduction in the risk of death.   The probability of remaining in response through 8 years was more than doubled with nivolumab plus ipilimumab versus sunitinib in the ITT population at 48% versus 19%, and in the intermediate and poor-risk population at 50% versus 23%. The other important observation is that patients with favorable-risk disease appeared to have a 20% reduction in the risk for death at 9 years and more durable responses. This suggests a possible delayed benefit for ipi and nivo in this group since these differences were not seen in the earlier analysis.   No new safety signals emerged with longer follow-up, and the results confirm the use of ipi and nivo as a standard front-line combination therapy in this disease. Since this combination has been in widespread use for some years, the results are not surprising although the subgroup analysis suggesting benefit in favorable-risk patients is likely to inform practice in the future.   Today's second abstract is number is 8506, which was presented by Dr. Tony Mok from the Chinese University of Hong Kong, describing results from the phase 3 HERTHENA-Lung02 trial. This trial compared the antibody-drug conjugate patritumab deruxtecan with platinum-based chemotherapy in patients with EGFR-mutated advanced non-small cell lung cancer following a third-generation tyrosine kinase inhibitor (TKI).  Patritumab deruxtecan, also known as HER3-DXd, comprises a fully human anti-HER3 IgG3 monoclonal antibody conjugated to a topoisomerase 1 inhibitor payload, and showed activity in a previous phase 2 trial in patients relapsing after EGFR TKI and chemotherapy.   In this phase 3 study, this agent was compared with platinum-based chemotherapy in eligible patients with an EGFR-activating mutation who had previously received 1 or 2 EGFR TKIs, at least one of which was a third-generation drug, with relapse or progression after this therapy. Five hundred and eighty-six patients were enrolled, with progression-free survival as the primary endpoint.  The primary analysis showed a 9-month progression-free survival of 29% for the experimental arm compared with 19% for platinum-based chemotherapy, for a hazard ratio of 0.77 and a P value of 0.011. With higher progression-free survival rates at 6 months and 12 months, HER3-DXd also had a better objective response rate (35.2% versus 25.3%) compared with platinum-based chemotherapy (PBC), and HER3-DXd also extended intracranial progression-free survival compared with PBC in patients with brain metastases, with a hazard ratio of 0.75. Grade 3 or more treatment-related adverse events occurred in 73% of patients treated with HER3-DXd and 57% of patients who received PBC. HER3-DXd had a higher rate of grade or more 3 thrombocytopenia, and drug-related interstitial lung disease occurred in 5% of patients in the HER3-DXd arm.   The follow-up will need more time to mature since no overall survival data are currently available, but definitely an agent to watch with interest. Moving on to today's final abstract, 8500, was presented by Dr. Pasi Jänne from the Dana-Farber Cancer Institute, describing results from the phase 2 portion of the KRYSTAL-7 study. This study is exploring the use of a potent KRAS inhibitor, adagrasib, in combination with pembrolizumab in patients with advanced or metastatic KRASG12C- mutated non-small cell lung cancer.  Adagrasib has already received accelerated approval in the U.S. for previously treated locally advanced or metastatic NSCLC with a KRASG12C mutation. A previous report from the KRYSTAL-7 study demonstrated encouraging activity in combination with pembrolizumab in the frontline setting for this patient group who also had more than 50% expression of PD-L1. The presentation today described efficacy and safety data for this drug combination across all PD-L1 expression levels.  One hundred and forty-nine patients with a median age of 67 years were treated with the combination, 104 of whom had PD-L1 expression level results available, representing the so-called biomarker population in this trial. The overall response rate for the entire study population was 44%. In the biomarker population, the overall response rate ranged from 36% in those with less than 1% PD-L1 expression to 61% for those with more than 50% expression. For all patients, the median response duration was just over 26 months, and the median progression-free and overall survival rates were 11 and 18.3 months respectively.    For the biomarker population, the median progression-free and overall survival were highest in those patients with more than 50% PD-L1. No new safety issues emerged from this analysis; the most frequent toxicities were nausea, diarrhea, and increases in transaminases. Immune-related toxicities included pneumonitis, hypothyroidism, and hepatitis. These are important results and the results of the phase 3 portion of KRYSTAL-7, which compares first-line therapy with adagrasib plus pembro versus pembro alone in the KRASG12C mutated/PD-L1 more than 50% group, will be informative. For those patients with lower levels of PD-L1 expression, the authors suggest that the treatment escalation may be beneficial, possibly including the addition of chemotherapy.  That concludes today's report. Thanks for listening and I hope you will join me again tomorrow to hear more top takeaways from ASCO25. If you value the insights that you hear on the ASCO Daily News Podcast, please remember to rate, review, and subscribe wherever you get your podcasts.  Disclaimer:  The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement.  Find out more about today's speaker:    Dr. John Sweetenham    Follow ASCO on social media:     @ASCO on Twitter    @ASCO on Bluesky    ASCO on Facebook    ASCO on LinkedIn     Disclosures:   Dr. John Sweetenham:    No relationships to disclose

Kyle Walkerfalse

Luke Thomas, Brian Campbell and the Morning Kombat crew are back on a Friday to preview this weekend's UFC Fight Night featuring Erin Blanchfield vs. Maycee Barber. The fellas go through the latest boxing headlines including PBC previews of Caleb Plant vs. Armando Resendiz and Jermall Charlo vs. Thomas Lamanna. Plus, Teofimo Lopez going after Turki Alalshikh in a social media outburst costs him. What do LT and BC make of the latest antics from Lopez? And the UFC might make a return to ESPN. Will it go over well with the fanbase? Happy Friday Donks!See omnystudio.com/listener for privacy information.

Most of the rhetoric today uses the second coming of Christ to strike fear in our minds. If a preacher says, “Are you ready for His coming?”, it usually refers to making sure you are eternally saved, so when He shows, you will be ready in that way. But the Bible teaches eternal salvation is …

A familiar fighter returns to the Las Vegas limelight, plus, some prominent fighters are in the news for the wrong reasons and we explain it all on the newest "Big Fight Weekend Preview Podcast."Host T.J. Rives and insider Dan Rafael are back aboard to go over everything.They begin with:A Recap of the Ohashi Promotions card on Wednesday in Yokohama, JapanYoshiki Takei TKO1 Yuttapong Tongdee and retains WBO bantamweight title.Plus, Eduardo Nunez wins easily in 12 rounds over Masanori Rikiishi and wins the vacant IBF junior lightweight title. Dan has a lot on both Next, a Preview of the PBC on Prime Video card Saturday night at Mandalay Bay in Las VegasCaleb Plant returns against little known. Armando Resendiz, 12 rounds, for Plant's WBA interim super middleweight title. More importantly is he's likely fighting Jermall Charlo next. Charlo first takes on. Thomas LaManna in a 10 rounds super middleweight bout. The boys discuss.NewsJaime Munguia tested positive for foreign testosterone in his system in a VADA test related to his May 3rd rematch win over Bruno Surace. What's going to happen now and does Surace get the no-contest ruling?  Dan has more on his reporting on the supposed Aug. 16 Teofimo Lopez-Devin Haney agreed to bout, but fight falling apart over Lopez's tweet storm in which he insulted Turki Alashikh. WHAT ARE WE DOING HERE?!Ryan Garcia undergoes right hand surgery, and the plans for Fall fight in limbo for now.Top Rank July 26th card officially announced, Xander Zayas-Jorge Garcia for vacant WBO junior middleweight title & featherweight Bruce “Shu Shu” Carrington vs. Mateus Heita for the vacant WBC interim title in the co-featureYudai Shigeoka, the former WBC strawweight titlist, posted to social media on Thursday to provide an update on older brother and former IBF strawweight titlist Ginjiro Shigeoka, including that he is breathing on his own.NostalgiaWe encourage you to find our Youtube page for some thoughts on HOFer Johnny Tapia, a fan favorite, who died back on May 27, 2012 – 13 years ago on Tuesday.Meanwhile, for all our podcat content keep it locked in on this feed on Apple/Spreaker/Spotify, etc.! 

Ep 179: The boys D-Rock and Joey D are back and better than ever for another great show! After a week's hiatus, flyweights Maycee Barber and Erin Blanchfield headline the Apex for UFC Vegas 107 in a number one contender showdown. We also discuss some PBC boxing with names like Caleb Plant and Jermall Charlo. As always, there will be combat sports news towards the end of the show. So, make sure you hit that like button; subscribe, rate, review, and leave a comment about what you'll be betting on this weekend.Watch On Youtube: https://www.youtube.com/live/pjxoFDSH2Zc?si=eyhbiWwN-10YP_ie#UFC #UFCVegas107 #Boxing #PBC #AKP179 #MMAPicks #FreePicksFollow Axe Kick Picks on X:@AxeKickPicksFollow Axe Kick Picks on IG:@akp_liveFollow the boys on X:Dylan: @rockk24Joey D: @10secondsleft_Follow the boys on IG:Dylan: @yorockk24Joey D: @10secondsleft_

A familiar fighter returns to the Las Vegas limelight, plus, some prominent fighters are in the news for the wrong reasons and we explain it all on the newest "Big Fight Weekend Preview Podcast."Host T.J. Rives and insider Dan Rafael are back aboard to go over everything.They begin with:A Recap of the Ohashi Promotions card on Wednesday in Yokohama, JapanYoshiki Takei TKO1 Yuttapong Tongdee and retains WBO bantamweight title.Plus, Eduardo Nunez wins easily in 12 rounds over Masanori Rikiishi and wins the vacant IBF junior lightweight title. Dan has a lot on both Next, a Preview of the PBC on Prime Video card Saturday night at Mandalay Bay in Las VegasCaleb Plant returns against little known. Armando Resendiz, 12 rounds, for Plant's WBA interim super middleweight title. More importantly is he's likely fighting Jermall Charlo next. Charlo first takes on. Thomas LaManna in a 10 rounds super middleweight bout. The boys discuss.NewsJaime Munguia tested positive for foreign testosterone in his system in a VADA test related to his May 3rd rematch win over Bruno Surace. What's going to happen now and does Surace get the no-contest ruling?  Dan has more on his reporting on the supposed Aug. 16 Teofimo Lopez-Devin Haney agreed to bout, but fight falling apart over Lopez's tweet storm in which he insulted Turki Alashikh. WHAT ARE WE DOING HERE?!Ryan Garcia undergoes right hand surgery, and the plans for Fall fight in limbo for now.Top Rank July 26th card officially announced, Xander Zayas-Jorge Garcia for vacant WBO junior middleweight title & featherweight Bruce “Shu Shu” Carrington vs. Mateus Heita for the vacant WBC interim title in the co-featureYudai Shigeoka, the former WBC strawweight titlist, posted to social media on Thursday to provide an update on older brother and former IBF strawweight titlist Ginjiro Shigeoka, including that he is breathing on his own.NostalgiaWe encourage you to find our Youtube page for some thoughts on HOFer Johnny Tapia, a fan favorite, who died back on May 27, 2012 – 13 years ago on Tuesday.Meanwhile, for all our podcat content keep it locked in on this feed on Apple/Spreaker/Spotify, etc.! 

King David desired to bring the ark of the covenant home to his new house in Jerusalem. This was a good thing. But the way David went about it, displeased the Lord. How many times do we have issues we deal with, and we go about it the wrong way? In this message, I look …

We play catch up with the reports surrounding Turki and his plans for Canelo-Crawford and Teofimo's beef with him. And we look to the PBC on Prime weekend card.

• ¡EL PELEADOR MEXICANO JAIME MUNGUÍA DIO POSITIVO A METABOLITOS EXÓGENOS DE TESTOSTERONA, TIENE 10 DÍAS PARA SOLICITAR EL ANÁLISIS DE LA PRUEBA B!• ¡MARCO BARRERA OPINA SOBRE EL REGRESO DE PACQUIAO!• ¡EDUARDO NÚÑEZ GANA POR DECISIÓN EN JAPÓN!• WILLIBALDO GARCIA SE LLEVA POLÉMICO FALLO SOBRE RENE CALIXTO!• ¡CANELO ÁLVAREZ PRESENTA SU TORNEO DE GOLF EN CDMX!

About MariaMaria is the CEO of Socrait, PBC, bringing 30 years of experience in education, including classroom teaching, online learning design, and EdTech innovation. After the sale of Coursetune, where she was co-founder and CEO, Maria just wanted to go back to teaching and embarked on an “adventure” into K-12 education as a teacher at Beehive Academy of Science and Technology. Her current work focuses on leveraging AI and advanced technologies to tackle some of the most pressing challenges in education today. Maria lives in Utah, where she enjoys hiking in slot canyons, camping in a tiny trailer, and being walked by her two huskies.Links AI Detective Gamehttps://socrait.com/getting-started/https://x.com/Socrait_PBChttps://socrait.com/about/ https://socrait.com/alpha100/About RachelleEducator, Keynote Speaker, Consultant, Attorney, and AuthorSubscribe to my ⁠newsletter⁠.Check out my ⁠blog⁠ and submit a guest blog.Contact me for speaking & training related to AI, AI and the law, Cybersecurity, SEL, STEM, and more!⁠bit.ly/thriveineduPD⁠Interested in a sponsored podcast or collaboration? Contact me! Rdene915@gmail.com

Have we been affected by worldwide deceptions like global warming or evolution? Or have we been affected by lying? Or what about slander or gossip? Have we experienced personal attacks during opportunities to minister? Have we ever dealt with betrayal? Have we refused to forgive others? Has our family been attacked in some way? Has …

In the final message of the May meeting, Elder Graham Sims speaks about the ways in which the Lord restores vision. Sometimes it can be in a physical way like Jesus did with the blind, but sometimes it can be spiritual vision. 05.04.25.Restoring.Vision.Graham.Sims

In the first message of our recent annual meeting, Elder Tim Lawrence of Bethel PBC near Nashville, preaches about sticking to the script, or scriptures. The Lord has preserved for us in His Word everything we need to know about Him and about how to navigate the pitfalls of this fallen world. 05.03.25.Sticking.to.the.Script.Tim.Lawrence

On this edition of the show, insider Dan Rafael is one on one with former IBF world super middleweight champ Caleb Plant.Plant, who defends the WBA's "interim super middleweight title" against Armando Resendiz in the main event of the PBC on Prime Video card on May 31 in Las Vegas, is looking to set up a fight later in the year against Jermall Charlo. Charlo is returning from a long layoff in the co-feature.They covered a variety of topics including, Caleb being in the ring with Canelo Alvarez in an undisputed 168 lb. title bout in 2022 and whether, he believes there could be a rematch down the line or not?It's all on this special edition of the "Fight Freaks Unite Podcast" on this feed and make sure to follow/subscribe on Apple/Spreaker/Spotify, etc.!And, also SEE this interview on our Big Fight Weekend Youtube page!

Discover how to recognize the burden of primary biliary cholangitis (PBC)-associated pruritus and make evidence-based treatment decisions to improve patient quality of life. Credit available for this activity expires: 5/22/26 Earn Credit / Learning Objectives & Disclosures: https://www.medscape.org/viewarticle/breaking-news-what-youre-itching-know-about-primary-biliary-2025a1000clq?ecd=bdc_podcast_libsyn_mscpedu

On this edition of the show, insider Dan Rafael is one on one with former IBF world super middleweight champ Caleb Plant.Plant, who defends the WBA's "interim super middleweight title" against Armando Resendiz in the main event of the PBC on Prime Video card on May 31 in Las Vegas, is looking to set up a fight later in the year against Jermall Charlo. Charlo is returning from a long layoff in the co-feature.They covered a variety of topics including, Caleb being in the ring with Canelo Alvarez in an undisputed 168 lb. title bout in 2022 and whether, he believes there could be a rematch down the line or not?It's all on this special edition of the "Fight Freaks Unite Podcast" on this feed and make sure to follow/subscribe on Apple/Spreaker/Spotify, etc.!And, also SEE this interview on our Big Fight Weekend Youtube page!

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It's another lighter weekend of action, although there is a prominent world title on the line in the Far East. We go over the matchups and have plenty of news, including Manny Pacquiao confirming his return and more on the "Big Fight Weekend Preview Podcast"Host T.J. Rives returns with insider Dan Rafael to go over it all on this edition.They start with the preview of the Queensberry DAZN card Saturday in Glasgow, ScotlandFormer undisputed 140 lb. champ Josh Taylor is back meeting a little known fighter in Ekow Essuman, in a welterweight clash. Does Taylor have anything left?Also, promising heavyweight Moses Itauma is on this card against little known Mike Balogun and it should be a big night for Itauma. The boys also preview the Kameda Promotions / ProBox TV main event Saturday in Osaka, JapanThis sees the return of American Angelo Leo against Tomoki Kameda, for Leo's IBF featherweight title in his first defense. Leo has big things in mind, but is going on the road in this one. Next, here briefly from former IBF 168 lb. champ Caleb Plant with DanPlant defends WBA interim super middleweight title vs. Armando Resendiz in the PBC on Prime Video main event May 31 at Mandalay Bay in Las Vegas News Pacquiao is officially back, and announces July 19th Mario Barrios fight on social media. His training has opened with Freddie Roach at Wild Card boxing club in L.A.Also, Dan is reporting that besides the bouts he's already reported that will be on the PPV (Fundora-Tszyu 2 and Pitbull-Fierro 2), the PPV will also include former 122 lb. and 126 lb. titlist  Brandon Figueroa vs. former title challenger Joey Gonzalez.Former IBF junior welterweight titlist Liam Paro will face Jonathan Navarro in a 10-rounder contracted at 144 pounds in the main event of a No Limit Boxing card on June 25 in Cairns, Australia. Paro's first fight since losing the IBF 140 title to Richardson Hitchins in December.And, we talk more about the death of all-time great Nino Benvenuti at 87 earlier this week.. The Italian legend was 1960 Olympic gold medalist, undisputed junior middleweight champion, two-time undisputed middleweight champion and was 2-1 in one boxing's most famed trilogies against Emile Griffith all for the undisputed 160 title. Some knowledge for the younger fans!Nostalgia May 22, 2010 – 15 years go on Thursday – the unfortunate fourth fight between featherweights Rafael Marquez and Israel Vazquez, who predictably got destroyed via KO3 in his final fight. and....May 22, 1993 – 32 years ago on Thursday – Roy Jones easy wiped out Bernard Hopkins in 12 rounds to win the vacant IBF middleweight title for his first world title in the co-feature of Riddick Bowe's easy KO2 in a mismatch with Jesse Ferguson to retain the heavyweight title. Goto our Big Fight Weekend Youtube paget to watch these here: https://www.youtube.com/@bigfightweekend9132/featuredAnd make sure to follow this podcast feed on Apple/Spreaker/Spotify, etc.! 

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OpenAI's recent announcement that its nonprofit would “retain control” of its for-profit business sounds reassuring. But this seemingly major concession, celebrated by so many, is in itself largely meaningless.Litigator Tyler Whitmer is a coauthor of a newly published letter that describes this attempted sleight of hand and directs regulators on how to stop it.As Tyler explains, the plan both before and after this announcement has been to convert OpenAI into a Delaware public benefit corporation (PBC) — and this alone will dramatically weaken the nonprofit's ability to direct the business in pursuit of its charitable purpose: ensuring AGI is safe and “benefits all of humanity.”Right now, the nonprofit directly controls the business. But were OpenAI to become a PBC, the nonprofit, rather than having its “hand on the lever,” would merely contribute to the decision of who does.Why does this matter? Today, if OpenAI's commercial arm were about to release an unhinged AI model that might make money but be bad for humanity, the nonprofit could directly intervene to stop it. In the proposed new structure, it likely couldn't do much at all.But it's even worse than that: even if the nonprofit could select the PBC's directors, those directors would have fundamentally different legal obligations from those of the nonprofit. A PBC director must balance public benefit with the interests of profit-driven shareholders — by default, they cannot legally prioritise public interest over profits, even if they and the controlling shareholder that appointed them want to do so.As Tyler points out, there isn't a single reported case of a shareholder successfully suing to enforce a PBC's public benefit mission in the 10+ years since the Delaware PBC statute was enacted.This extra step from the nonprofit to the PBC would also mean that the attorneys general of California and Delaware — who today are empowered to ensure the nonprofit pursues its mission — would find themselves powerless to act. These are probably not side effects but rather a Trojan horse for-profit investors are trying to slip past regulators.Fortunately this can all be addressed — but it requires either the nonprofit board or the attorneys general of California and Delaware to promptly put their foot down and insist on watertight legal agreements that preserve OpenAI's current governance safeguards and enforcement mechanisms.As Tyler explains, the same arrangements that currently bind the OpenAI business have to be written into a new PBC's certificate of incorporation — something that won't happen by default and that powerful investors have every incentive to resist.Full transcript and links to learn more: https://80k.info/twChapters:Cold open (00:00:00)Who's Tyler Whitmer? (00:01:35)The new plan may be no improvement (00:02:04)The public hasn't even been allowed to know what they are owed (00:06:55)Issues beyond control (00:11:02)The new directors wouldn't have to pursue the current purpose (00:12:06)The nonprofit might not even retain voting control (00:16:58)The attorneys general could lose their enforcement oversight (00:22:11)By default things go badly (00:29:09)How to keep the mission in the restructure (00:32:25)What will become of OpenAI's Charter? (00:37:11)Ways to make things better, and not just avoid them getting worse (00:42:38)How the AGs can avoid being disempowered (00:48:35)Retaining the power to fire the CEO (00:54:49)Will the current board get a financial stake in OpenAI? (00:57:40)Could the AGs insist the current nonprofit agreement be made public? (00:59:15)How OpenAI is valued should be transparent and scrutinised (01:01:00)Investors aren't bad people, but they can't be trusted either (01:06:05)This episode was originally recorded on May 13, 2025.Video editing: Simon Monsour and Luke MonsourAudio engineering: Ben Cordell, Milo McGuire, Simon Monsour, and Dominic ArmstrongMusic: Ben CordellTranscriptions and web: Katy Moore

In the Saturday morning message of our recent May meeting, Elder Graham Sims, pastor of Wilson Creek PBC near Franklin, TN, preaches from the first chapter of Ephesians. As a prison epistle, Paul wrote this to the troubled church at Ephesus, who apparently was beginning to forget their first love. Paul’s first few lines seek …

In the Saturday afternoon service, Brother Graham looks at Psalms 46 and observes how the Lord is our refuge. 05.03.25.God.is.Our.Refuge.Graham.Sims

In the final message on Saturday, Elder Tim Lawrence, member of Bethel Primitive Baptist Church of Nashville, TN, preaches about the miraculous ways that the Lord manifests Himself even now. 05.03.25.He.Will.Manifest.Himself.Tim.Lawrence

From the days of Isaac, when he asked his father Abraham, where was the Lamb, up until this very hour, the Lord will providentially make sure we are taken care of. This does not mean we should expect an easy life. But it does mean that the Lord is the Provider of all that we …

Romans 4:25 tells us that Jesus was delivered for our offenses and raised again for our justification. Do we recognize that we have sin? Or do we justify ourselves when it comes to our sin. I would rather acknowledge that I do have sin, and trust in the Lord Jesus for my justification in spite …

What is something that could happen to you today that would make you happy? A new car, becoming debt free, running into an old friend, or maybe finding out you are the heir to a fortune? It is an endless list of things we may say. How many of us would say that being corrected …