Podcasts about FMT

Introduction In this solo episode, Darin dives into a practice that has been both revered and misunderstood across history: the enema. From ancient Egypt and Mayan rituals to Ayurveda and modern biohacking, enemas have long been used as tools for cleansing, hydration, and targeted healing. Darin shares his own two-decade experience with enemas — from parasite cleanses to coffee enemas — and explores the science, history, and red flags you need to know. This is not medical advice, but an invitation to learn from ancient wisdom and consider how these practices might support your own healing journey.     What You'll Learn 00:21 – Why enemas have been used for thousands of years, from Egypt to the Maya 01:33 – Parasite cleansing, hydration, and creating an environment for balance 02:38 – Pharaohs' “shepherds of the king's rectum” and enemas in ancient medical texts 03:20 – Ayurveda protocols for cleansing, oils, and elimination support 04:25 – The Maya's ritual use of enemas, including psychoactive delivery 05:22 – Enemas as lifesaving hydration in medical history (Murphy's Drip) 06:30 – FDA-approved microbiome enemas and rapid constipation relief 07:24 – Parasite cleanses, detox protocols, and Darin's own experiences 08:38 – Why we all live with parasites and how enemas help restore balance 09:19 – Ancient wisdom vs. modern medicine: why we need both 10:19 – Coffee enemas, liver support, detox, and peristalsis stimulation 11:20 – Lights turning back on: Darin's personal benefits from enemas 12:20 – Red flags: who should not do enemas (IBD, bleeding, surgeries, etc.) 13:47 – The importance of fiber, microbiome support, and daily practices 15:21 – Why Darin does two enemas a week and how they “turn the lights back on” 16:32 – Closing reflections: enemas as ancient tools for hydration, cleansing, and microbiome health     Thank You to Our Sponsors: Therasage: Go to www.therasage.com and use code DARIN at checkout for 15% off Our Place: Toxic-free, durable cookware that supports healthy cooking. Use code DARIN for 10% off at fromourplace.com.     Find More from Darin Olien: Instagram: @darinolien Podcast: SuperLife Website: https://superlife.com Book: Fatal Conveniences     Key Takeaway “From the pharaohs to Ayurveda to modern biohacking, enemas have always been about accessing the body in powerful ways. Used with care and wisdom, they can reawaken ancient practices of cleansing, hydration, and healing.”     Bibliography & Sources Egypt / Antiquity: Hektoen Int'l on the Shepherd of the Rectum; overview of Egyptian proctology terms. Encyclopedia Pub Ayurveda (Basti): Classical reviews and practitioner summaries of Nirūha/Anuvāsana, indications, and protocols. IJRAPCalifornia College of Ayurveda Maya ritual enemas: Carod-Artal review (2015) and De Smet et al. on ritual enemas/psychoactives; museum/archaeological overviews with ceramic scenes. ScienceDirect+1 Rectal rehydration / proctoclysis: Wilderness case report of successful rectal ORS in hemorrhagic shock; historical review of proctoclysis as standard therapy (late 19th–early 20th c.). SAGE JournalsPMC Constipation/impaction patient education: Cleveland Clinic guidance on when/how enemas are used. Cleveland Clinic Parasite obstruction (Ascaris): pediatric surgical series noting hypertonic saline enemas for colonic worm disentanglement; newer case discussions. Lippincott JournalsPMC Microbiome therapy (powerful modern rectal route): FDA approval docs and clinical literature for REBYOTA(enema) and FMT efficacy. U.S. Food and Drug AdministrationCleveland Clinic Journal of Medicine Risks & what to avoid: FDA safety communication on phosphate enemas; case report of coffee-enema proctocolitis; reviews cautioning routine “colon cleansing.” U.S. Food and Drug AdministrationPMC

What happens when a preventable infection takes the life of someone you love? In this episode, Christian John Lillis shares the heartbreaking story of losing his mom to C. difficile, a bacterial infection, and how that loss inspired his mission to fight back. He talks about what everyone needs to know about C. diff: the warning signs, how it spreads, the importance of early treatment and steps we can all take to prevent it becoming more serious. This is more than a story of loss—it's a call to action for awareness, advocacy and protecting our loved ones. Lindsey Parsons, your host, helps clients solve gut issues and reverse autoimmune disease naturally. Take her quiz to see which stool or functional medicine test will help you find out what's wrong. She's a Certified Health Coach at High Desert Health in Tucson, Arizona. She coaches clients locally and nationwide. You can also follow Lindsey on Facebook, Tiktok, X, Instagram or Pinterest or reach her via email at lindsey@highdeserthealthcoaching.com to set up your free 30-minute Gut Healing Breakthrough Session. Show Notes

In this VETgirl online veterinary continuing education podcast, we chat with Jenessa A. Winston, DVM, PhD, DACVIM (SAIM), Associate Professor of Small Animal Medicine at the Ohio State University about the importance of microbiome for and beyond, gut health. What is the microbiome, and what type of gastrointestinal (GI) microorganisms are we talking about? How does GI microbiome apply to us in clinical daily practice? What role does the GI microbiome play with acute hemorrhagic diarrheal syndrome to chronic enteropathy to parvovirus, and does fecal microbiota transplantation (FMT) help too? Tune in to learn about how you can support microbiome and the whole patient's health!Sponsored By: Hills

Dr. Sumanta (Monty) Pal and Dr. Arielle Elkrief discuss the clinical relevance of the gut microbiome in cancer immunotherapy and the importance of antibiotic stewardship, as well as interventions currently being explored to treat gut dysbiosis and optimize immunotherapy response. TRANSCRIPT Dr. Sumanta (Monty) Pal: Hi everyone, I'm Dr. Monty Pal, welcoming you to the ASCO Daily News Podcast. I'm a medical oncologist. I'm a professor and vice chair of academic affairs at the City of Hope Comprehensive Cancer Center in Los Angeles.  Today we're here to discuss one of my favorite topics, which is the gut microbiome. It's almost hard to avoid the gut microbiome nowadays if you look at medical literature within oncology. It's an emerging phenomenon, but there are a couple of individuals that I would really define as pioneers in the field. And one of them is actually with me today, Dr. Arielle Elkrief, to discuss the clinical relevance of the gut microbiome, particularly amongst patients receiving immunotherapy, although I imagine our conversation today will take many twists and turns. Arielle is an assistant professor and clinician scientist in the Department of Oncology at the University of Montreal, and she is co-director of the CHUM Microbiome Center there.  FYI for the listeners, we have our full disclosures in the transcript of this episode.  Arielle, thank you so much for joining us today. Dr. Arielle Elkrief: Thanks so much, Monty. This is going to be amazing. Dr. Sumanta (Monty) Pal: Well, I have to tell you what sort of inspired me to bring you on as a guest. It was one of many things, but it was this really terrific ASCO Educational [Book] article that you wrote. Now, I have to tell you, I've read all the articles sort of cover to cover in the book, and they're always a wonderful primer, so if our audience is studying for board research or something of that sort, it's a terrific resource to go through. I have to tell you, this piece on the gut microbiome that you wrote is nothing short of a masterpiece. If you read this cover to cover, it's actually going to give you, I think, a sense of the current state and future state of the field. I wanted to start by just sort of beginning with sort of the origin story for a lot of this, which is this association between the gut microbiome and immunotherapy response. This takes us back several years to this pivotal series of papers in Science. Maybe you could walk our audience through that. Dr. Arielle Elkrief: Absolutely. Well, thank you so much for your kind words about the ASCO [Educational] Book. It was a team effort with a lot of key opinion leaders in the field, so I'm really glad to learn that you've liked it.  Moving backwards in terms of how we came to understand that the gut microbiome is essential to priming a response to cancer immunotherapy actually goes back to 2015 and seminal papers that looked at what happens when we take mice that are germ-free mice that have never been exposed to a microbiome. These are mice that are born by cesarean section and essentially live in a bubble. And when we give those mice tumors and treat them, in the first papers with anti-CTLA-4 treatment, we realized that these antibodies don't work at all. And that was the first observation that the presence of a gut microbiome was essential to mounting an anti-cancer immune response. When we supplemented those same mice with beneficial bacteria or feces from responder patients, we were able to restore the response to immunotherapy. And so those were really the first preclinical observations that made us understand the critical role of the microbiome in immunotherapy response. Moving a little bit in the future, we examined the fecal microbiome composition using shotgun metagenomic sequencing in different cohorts of patients with solid tumors, namely lung cancers, kidney cancers, and also skin tumors like melanoma, and found that patients who responded to immunotherapy had a distinct microbiome that was characterized by beneficial bacteria compared to patients who experienced resistance to immunotherapy that had a dysbiotic or diseased microbiome. Dr. Sumanta (Monty) Pal: So, you know, it's interesting, these techniques that we're using to sequence the gut, they're a little bit different. So I wonder if you can give the audience a quick primer on these techniques that you're so well versed in, shotgun metagenomic sequencing, 16S rRNA sequencing. If you had to describe this in 30 seconds, which is a tall task, how would you do that? Dr. Arielle Elkrief: That's a tall task. Much of what we know about the microbiome initially came from a technique called 16S rRNA sequencing. This is a technique that amplifies the 16S region and basically tells you at the genus level what's going on at the level of bacterial composition. This technique is fast, relatively cheap, and can be performed on a laptop computer, which is excellent. The problem is that it's prone to a lot of technical variations. Different primers might give you different results, and you're really limited at the genus resolution. You can't get a good resolution in terms of species, and we're learning that different species from the same genus might have different physiological properties, and the same thing goes at the strain level. So when we really zone in and look at inter-species changes, we're seeing that these actually have specific functions in the host. So that brings us to metagenomic sequencing, which is a whole genome sequencing, next-generation sequencing based method that looks at the whole composition and gives you information not only on bacteria, but you might also get fungal and viral properties. You can zoom in on the strain level. You can also get functional output, so we can examine what the metabolic properties of specific species or strains might look like. The negative aspects of shotgun metagenomic sequencing is that it takes a lot of computational power in order to analyze the results and it might take a little bit longer. And certainly, within the clinical setting, not something that's feasible yet.  And that brings us to more novel point-of-care biomarker tools that we've collaborated in developing along with Dr. Laurence Zitvogel and Dr. Lisa Derosa at Gustave Roussy, that learning from the shotgun metagenomics results designed a probe using quantitative PCR which looks for this specific bacteria we know to be important and developed a ratio of harmful bacteria to beneficial bacteria. This is called the TOPOSCORE, and it actually is able to predict quite nicely the response to immunotherapy using a stool sample and a really good turnaround time of almost 72 hours. Dr. Sumanta (Monty) Pal: That was a perfect overview and a lot of information in a short amount of time. It also makes you take out your high school biology textbooks, doesn't it, to understand that the bacterial ribosome, right, is a different size and shape, and that's what we're sequencing here. But these techniques I think are incredibly important, and I'm glad you actually discussed this, this RT-PCR based strategy of calculating the TOPOSCORE. It lends itself to this phenomenon of dysbiosis, and I think for our audience, that's going to be an important term to understand as time goes on. There's the normal healthy gut and then there's this phenomenon of dysbiosis, which is, I guess, simply put, an unhealthy gut. But tell us about, you know, how often you see dysbiosis in a cancer patient, maybe versus a normal healthy adult. Dr. Arielle Elkrief: So, I think we can split up your question into two parts. One is we know from cohort studies and population level-based studies that the microbiome of patients with cancer is distinct from healthy patients or healthy people. And we know that because of the global composition. We also think that there are diversity metrics that lend themselves to being described as dysbiotic. But we do know that the microbiome of people with cancer is distinct from healthy volunteers. That's the first point.  In terms of how frequently dysbiosis occurs in patients with cancer, it's not very well defined. We know that even among healthy people, there is a certain level of dysbiosis. Laurence in her talk mentioned that to be about 10% to 20%. And the other fascinating component is that when we're thinking about dysbiosis and the cancer associated microbiome, in terms of the species that are enriched, it's quite striking that a lot of these dysbiotic or negative bacteria are also found to be enriched in patients with metabolic disease, like cardiovascular disease, for example. And so it's unclear if dysbiosis is the cause or consequence, but there definitely seems to be a general pattern of disease when looking at the microbiome compared to healthy people. Dr. Sumanta (Monty) Pal: That's interesting. So, I'll tell you, my second favorite portion of your article, and I'll tell you my favorite portion as well in the context of this podcast, but my second favorite part was the section around antibiotic stewardship. You know, the utilization of antibiotics in a very pragmatic fashion amongst our patients. Can you describe why that's so critical in the context of the microbiome? Dr. Arielle Elkrief: Antibiotics can disrupt the gut microbiome composition. We know this from mouse studies, but also cohort studies of patients that are exposed to antibiotics. And most importantly, we know that patients who are exposed to antibiotics, either before or during the immunotherapy period, have significantly worse progression-free survival and overall survival to immunotherapy. And this is true for immunotherapy in the monotherapy setting, but also when combined with chemotherapy. What's striking is that when we look at patients who are just treated with chemotherapy, we don't see the negative outcome of antibiotics on outcome and progression-free survival and overall survival, suggesting that the negative impact of antibiotics on outcomes is really specific to immunotherapy backbones. The other important point is that this negative signal is maintained even after adjusting for standard prognostic variables in the specific malignancies that we're looking at. And then most importantly, at the mechanistic level, we were able to actually pinpoint the mechanism behind this antibiotic related dysbiosis. And we see this with a bloom of negative bacteria which induces a loss of MAd-CAM, which is an endothelial gut checkpoint immune marker, and that causes an efflux of immunosuppressive T cells, which are usually in the gut, to go straight into the tumor where they make the tumor unamenable to an immunotherapy response. And so now we finally have the mechanism as to why antibiotics are harmful and why we need to practice antibiotic stewardship. Dr. Sumanta (Monty) Pal: And just to be clear for the audience, I mean, if a patient needs antibiotics, they need antibiotics. But perhaps it just suggests that, and we have, I suppose, this predilection as oncologists, just for the minor cold or cough or what have you, we maybe should be a little bit more cognizant of whether or not antibiotics are truly necessary. Is that fair? Dr. Arielle Elkrief: Absolutely. So what we're advocating for is antibiotic stewardship, and this is the clear recommendation that we can make. So that means confirming a bacterial infection. If it's there and antibiotics are indicated, to choose the most narrow spectrum for the shortest course and constantly re-evaluate the indication of antibiotics. And of course, we need to work with our colleagues in infectious diseases who've done incredible work in antibiotic stewardship. And all along this process we also need to be mindful of other medications and polypharmacy, such as proton pump inhibitors or narcotics, for example, we think that these other medications which are frequently prescribed in our cancer population can also potentially have negative impacts on the microbiome and immunotherapy response. Dr. Sumanta (Monty) Pal: I think that's a terrific summary and big guidance for the audience.  I promised you I'd tell you my favorite part of your article, and this is this huge table. I think the table is two and a half pages long, if I remember correctly, but it's an awesome table, and I highly recommend our audience to check this out. It lists literally every therapeutic trial for the microbiome under the sun. And so it begins with the approach of fecal microbiota transplant, which I'm going to ask you to tell us about in a second, but it also hinges on a lot of really cool sort of novel therapies, live bacterial products, mixes of different microbial products. Maybe take us through this whole approach of FMT (fecal microbiota transplantation). I actually wasn't aware of the dozens of trials that you listed there in this space. It seems like it's a very active area of research. Dr. Arielle Elkrief: Definitely. So, as you alluded to, FMT or fecal microbiota transplantation is the most well studied and direct way to modify the patient's microbiome. This technique aims to replace the patient's dysbiotic microbiome with that of a healthy microbiome, either from a healthy donor volunteer that's been heavily screened, or from a patient who experienced response to immunotherapy. And, as three landmark studies so far that have been published demonstrated the potential of FMT to reduce primary resistance or secondary resistance to immunotherapy, and this has been in melanoma.  We also recently reported on the results of our FMT-LUMINate trial, which looked at patients with lung cancer and melanoma. Once again, FMT, when combined with immunotherapy was safe and led to a higher proportion of responses than we would normally expect.  We're now also looking at randomized trials that have come out. So the first being the TACITO trial in kidney cancer, which compared FMT plus pembrolizumab and axitinib to placebo in patients with RCC, and again, FMT was safe and feasible and also led to an increased progression-free survival at one year, meeting the study's primary endpoint.  And so, so far, there's a wealth of data really showing the promise of FMT when combined with immunotherapy, and we're now in the process of conducting larger randomized trials, including in melanoma with the CCTG (Canada Cancer Trials Group) in our ME17 or Canbiome2 trial, where we're going to be enrolling 128 patients with metastatic melanoma to receive FMT and standard of care immunotherapy compared to standard of care immunotherapy alone. Dr. Sumanta (Monty) Pal: You're very humble, so I've got to highlight for our audience. This was a mega grant that Arielle received to fund really the largest prospective exploration of FMT that will exist to date. So I'm really excited about that. I wish this was something we could participate in stateside.  Before we jump into the other approach, which is live bacterial products and mixes thereof, where do you see FMT going? I think that one of the perceived challenges with FMT is that it's hard to implement, right? You need to have a really robust framework when it comes to gastroenterology, the preparation's challenging. Is there a way to envision FMT use being more generalized? Dr. Arielle Elkrief: Those are great questions. So we're lucky in Canada to work with pioneers in FMT, Michael Silverman, Saman Maleki, and John Lenehan in London, Ontario, who had this really robust FMT healthy donor screening program, which literally screens for every pathogen under the sun, and we haven't had any problems with feasibility or implementing FMT in Canada. But I think that once we're going to hopefully start doing larger scale, randomized phase three studies, that we might run into problems with scalability. And I think also with regards to reproducibility, and that's the feedback that we're getting from some regulatory authorities, especially at the level of the FDA, where there are some concerns around inter- and intra-donor variability because, of course, we can't guarantee that every fecal sample is going to be the same. So that has really pushed the field to think about other strategies, such as live biotherapeutic products which take modified FMT or bacteria from stools from either healthy donors or from responder patients and basically turn them into drugs that are regulated as drugs and can then be studied in the context of investigational new drugs or products. Dr. Sumanta (Monty) Pal: I like this and, you know, I do think that there's a future for it. We just have to kind of put our heads together and figure out how to get over all of these logistical hurdles, but, you know, I agree, I think your group and others have demonstrated, especially with this trial that you're fanning out all throughout Canada, that it can potentially be done.  This is a topic that could probably go on for another couple of hours, right, especially based on the size of the table that you put together in this brilliant article, but tell us about live bacterial products or LBPs, as we call them these days. What's the current status, what's the future there? And maybe I'll give you less than two minutes here, although again, I realize it's a two-hour topic. Dr. Arielle Elkrief: You're probably better suited to speak about that because you've been one of the pioneers in terms of this. So we can think about LBPs in terms of single strain organisms, like CBM588 for an example, which your group did some amazing work in showing that, in a randomized setting, that this led to better responses than we would expect compared to just work with controls. We also know that LBPs can have multiple strains, up to 30. We're collaborating with a company called Cannabis Bioscience that is actually working on much larger communities of consortia. And so we're really excited about the direction that that's taking in terms of taking these LBPs and developing them from the drug perspective. In addition to LBPs, we know that there are other ways that we can change the microbiome, notably prebiotics, which are compounds which can have a beneficial impact on the microbiome. And one of these is camu camu, which I know your group is leading a clinical trial looking at camu camu and kidney cancer, and we're excited to see how that compares to FMT or LBPs, because that might be a potentially scalable alternative. Dr. Sumanta (Monty) Pal: That's awesome. What a terrific overview, and that was less than two minutes. I don't know how you did it. That's terrific.  Arielle, this has been such an insightful conversation. I just want to thank you for, again, a terrific article in the ASCO Educational Book. I highly recommend all of our listeners to go there and check it out, and also for sharing all these terrific insights on the podcast today. Dr. Arielle Elkrief: Thank you so much, Monty. Dr. Sumanta (Monty) Pal: And thanks to our listeners, too. If you value the insights that you heard today on the ASCO Daily News Podcast, please rate, review, and subscribe wherever you get your podcasts. Thanks, everyone. Disclaimer: The purpose of this podcast is to educate and to inform. This is not a substitute for professional medical care and is not intended for use in the diagnosis or treatment of individual conditions. Guests on this podcast express their own opinions, experience, and conclusions. Guest statements on the podcast do not express the opinions of ASCO. The mention of any product, service, organization, activity, or therapy should not be construed as an ASCO endorsement. Find out more about today's speakers:    Dr. Sumanta (Monty) Pal  @montypal Dr. Arielle Elkrief Follow ASCO on social media:     @ASCO on Twitter    ASCO on Bluesky   ASCO on Facebook     ASCO on LinkedIn     Disclosures:    Dr. Sumanta (Monty) Pal:   Speakers' Bureau: MJH Life Sciences, IntrisiQ, Peerview  Research Funding (Inst.): Exelixis, Merck, Osel, Genentech, Crispr Therapeutics, Adicet Bio, ArsenalBio, Xencor, Miyarsian Pharmaceutical  Travel, Accommodations, Expenses: Crispr Therapeutics, Ipsen, Exelixis  Dr. Arielle Elkrief: Honoraria: AstraZenica, Bristol-Myers Squibb, Merck, EMD Serono Consulting or Advisory Role: Bristol-Myers Squibb Research Funding (Inst.): Kanvas Bioscience, AstraZeneca, Merck Other Relationship: Royal College of Surgeons and Physicians of Canada, Cedar's Cancer Center (Henry R. Shibata Fellowship), Canadian Institutes of Health Research (CIHR)

In this episode of the Ageless Future podcast, host Cade Archibald dives deep into the gut-brain connection and how detoxing the digestive system can revitalize the immune system, boost energy, and improve mental clarity. Cade explains how gut imbalances, toxin overload, and vagus nerve dysfunction can lead to chronic fatigue, inflammation, neurodegeneration, and other health challenges. He shares practical strategies such as targeted peptides, mitochondrial support, and anti-inflammatory nutrition, along with a four-week gut-brain detox action plan to heal the gut lining, restore microbial balance, and optimize detox pathways. Listeners also learn about advanced treatments like umbilical cord plasma therapy and fecal microbiota transplants, as well as simple daily habits to strengthen the gut-brain axis for long-term vitality. www.agelessfuture.com

Dominate C. diff! Learn to distinguish colonization from infection, select first-line therapies, and counsel patients on recurrence prevention and microbiome recovery. We're joined by IDSA past president and expert on foodborne and intestinal infections, Dr. Cindy Sears (Johns Hopkins University) for a comprehensive update on Clostridioides difficile (C. diff, Cdiff, CDAD, CDI). Claim CME for this episode at curbsiders.vcuhealth.org! Patreon | Episodes | Subscribe | Spotify | YouTube | Newsletter | Contact | Swag! | CME Show Segments 00:00 Intro 03:00 Guest bio and hobby 04:25 Case of Charles Fleur Fontaine 06:00 Risk factors and epidemiology 08:00 Antibiotic hierarchy of risk 10:00 Diagnosis, testing strategies 14:00 Defining severity 17:30 Treatment options 20:00 Microbiome recovery strategies 24:00 Probiotics and postbiotics 27:00 Infection control counseling 30:00 C. diff and colon cancer 32:00 Recurrent C. diff strategies 35:00 Why some FMT and bezlotoxumab were discontinued 38:00 Microbiota replacement therapies 43:00 Prophylaxis strategies 45:00 Future therapies and ongoing research 47:00 Audience Q&A 52:00 Outro Credits Written and Produced by: Matthew Watto, MD, FACP  Cover Art and Infographic by: Hosts: Matthew Watto MD, FACP; Paul Williams MD, FACP    Reviewer: Sai S Achi MD,MBA,FACP Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Technical Production: PodPaste Guest: Cynthia Sears MD Disclosures Dr. Sears reports no relevant financial disclosures. Dr. Williams financial relationships disclosed include a Merck grant or research support. This relationship has not ended. Sponsor: Mint Mobile  This year, skip breaking a sweat AND breaking the bank. Get this new customer offer and your 3-month Unlimited wireless plan for just 15 bucks a month at mintmobile.com/CURB  Sponsor: Panacea Financial Let Panacea Financial take the financial stress off your plate,so you can get back to doing what matters most. Visit panaceafinancial.com  Sponsor: FIGS Get15% off your first order at wearfigs.com with the code FIGSRX

In the episode of Ageless Future, we discuss groundbreaking exploration of Fecal Microbiota Transplantation (FMT) led by Drs. Jason Klop and Shaina Cahill from Novel Biome. They detailed how FMT is revolutionizing treatment for chronic, treatment-resistant conditions—ranging from GI disorders to neurological and autoimmune diseases—by restoring gut microbiome diversity. The discussion covered rigorous donor screening protocols, the three-phase treatment process (pretreatment, loading dose, maintenance), and why FMT outperforms probiotics. Real-world case studies showed improvements in digestion, cognition, sleep, and immune balance, with continued benefits months after treatment. The session also tackled treatment logistics, safety concerns, microbiome testing, and protocols for maintaining long-term success through diet and lifestyle. The collaborative concluded with strong enthusiasm for education, ethical sourcing, and integrating FMT into functional practices. www.agelessfuture.com

Jason Klop from Legacy Biome joins The Pet Parenting Reset podcast this week to talk about how Fecal Microbiota Transplant (FMT) can totally change the game for your dog's gut health. We dig into why FMT works for stuff like chronic diarrhea or low energy, and what makes Legacy Biome's approach—think super clean, natural sourcing—stand out. You'll get practical tips to weave FMT into your pet's routine for more vitality and less stress, all while keeping it holistic and real. Tune in to level up your pet parenting!Send us a text

Tuesday Headlines: Opposition Leader Sussan Ley admits "there is hunger and starvation in Gaza", New evidence released from Erin Patterson murder case, Thousands of murder, rape and assault cases to be re-examined due to DNA lab bungle, Property boom prompts surge in Australian millionaires to global high, Tesla awards chief executive Elon Musk $44 billion worth of shares. Deep Dive: You might have heard of donating blood and plasma, but what about donating your poo? Well it turns out your stool could help save lives in more ways than one. Right now in Australia poo donations are being used for fecal microbiota transplants, to help cure painful, debilitating and sometimes deadly diseases. In this episode of The Briefing, Tara Cassidy speaks with Kevin Young, an FMT recipient, about how the procedure saved his life, and Lifeblood’s Elizabeth Connolly on how it might be used in future. Follow The Briefing: TikTok: @thebriefingpodInstagram: @thebriefingpodcast YouTube: @LiSTNRnewsroom Facebook: @LiSTNR NewsroomSee omnystudio.com/listener for privacy information.

A new episode of FMT? In THIS economy?Join Rich, Dee and Steaky as they talk you through what's bene going on in their digital worlds this week.On this episode, we're joined by FMT alumni / royalty / all round good egg Callum for a podcast in thjree parts.Chapter 1: The Lionesses and how brilliant they areChapter 2 : Callum's FM meet-up and charity football match on August 16th at Slough townChapter 3: It all goes a bit (read: A LOT) off the rails. Squirrels. White Dog Poo. Just gets odd.VIVA LA FMT!Our links:linkre.ee/fmtpodCallum's links:twitch.tv/whycallumx.com/whycallum_Cupburger Mutual Aid:https://www.cupburger.org/https://opencollective.com/cupburger

#300 Today's guest is Dr. Andrea McBeth, a trailblazer in the world of microbiome therapeutics and the founder and CEO of Thaena — a company pioneering human-derived postbiotic solutions to support gut and whole-body health. Andrea holds a Bachelor's in Biochemistry with a focus on molecular biology from the University of San Diego, and earned her Doctorate in Naturopathic Medicine from the National University of Natural Medicine. Her early clinical work focused on functional GI disorders and autoimmunity, and she went on to launch one of the first stool banks for fecal microbiota transplantation to treat Clostridioides difficile infections. She's served as President of GastroANP and as adjunct faculty at NUNM, where she developed and taught graduate courses on the microbiome's role in nutrition. Passionate about bridging science and real-world healing, Andrea invented ThaenaBiotic, the first human-derived postbiotic supplement — and now leads the charge at Thaena to bring safe, scalable microbiome-based treatments to the world. In this episode, we explore: What regenerative health means in the context of human biology Why the microbiome is central to regeneration — and what a truly resilient gut ecosystem looks like How the microbiome supports repair and renewal throughout the body — from gut lining to immunity and even mood Which microbial species and metabolites stand out for their regenerative potential Daily habits and exposures that best nourish the microbiome and enhance its regenerative power Common lifestyle and environmental disruptors that undermine microbial diversity and function Whether the traditional health model focuses too heavily on eradicating pathogens (e.g., antibiotics, cleanses) instead of cultivating regeneration How Thaena is flipping the script through their unique product philosophy   You'll also hear from Dr. McBeth about the innovative postbiotics she's developed — including how Thaena sources and processes human-derived microbiome metabolites, what makes them safe, and how they differ from prebiotics, probiotics, and even FMT “crapsules.” And so much more.

Get your free verifiable CPD for this episode here >>> https://www.dentistswhoinvest.com/videos/dental-practice-market-outlook-2025-with-mr-luke-moore———————————————————————Curious about dental practice values in today's market? Wonder what's really happening with corporate buyers and whether NHS practices still command premium prices? The data might surprise you.Luke Moore, Head of Dental Elite's practice brokerage team, joins us to unpack the revealing findings from their annual dental market report—a comprehensive analysis representing roughly 25% of all UK dental practice transactions. This insider's view of completed sales (not just valuations) delivers eye-opening insights for anyone considering buying or selling a practice.We dismantle the prevailing "urban myth" that corporates dominate today's acquisition landscape. The reality? Independent dentists purchasing their first, second or third practices remain the primary buyers, while the largest groups have pivoted toward fewer, larger acquisitions with specific strategic focus.The conversation explores why mixed practices command the highest multiples from independent buyers (averaging 3.87x FMT), while private practices are the "jewels in the crown" for corporate buyers (averaging 7.36x EBITDA). Luke shares fascinating details about regional valuation disparities, with practices in recruitment-challenged areas selling for significantly lower multiples than their urban counterparts.Perhaps most revealing is the emerging trend of sellers prioritising complete payment at completion over potentially higher valuations with deferred components—a shift Luke attributes partly to mixed post-sale experiences reported by principals who've previously sold to larger groups.Whether you're a practice owner contemplating your exit strategy, an associate exploring ownership opportunities, or simply interested in the business of dentistry, this data-rich conversation provides crucial context for navigating today's complex dental marketplace.Earn complimentary verifiable CPD by completing the associated assessment through the link in our show notes.———————————————————————Disclaimer: All content on this channel is for education purposes only and does not constitute an investment recommendation or individual financial advice. For that, you should speak to a regulated, independent professional. The value of investments and the income from them can go down as well as up, so you may get back less than you invest. The views expressed on this channel may no longer be current. The information provided is not a personal recommendation for any particular investment. Tax treatment depends on individual circumstances and all tax rules may change in the future. If you are unsure about the suitability of an investment, you should speak to a regulated, independent professional. Investment figures quoted refer to simulated past performance and that past performance is not a reliable indicator of future results/performance.Send us a text

Dr. Sabine Hazen is a Gastroenterologist, Researcher, & CEO of Progena Biome. In this episode, she explains how fecal microbiota transplants (FMT) have the potential to treat Alzheimer's, Autism, Crohn's, Anxiety, Depression & Alopecia. She explains how it works, why mapping the microbiome is like mapping the human genome & interesting cases of personality changes post transplant. If you like this episode, you'll also like episode 188: BIOHACKING FOR DUMMIES: SUNSHINE, SLEEP & SHIVERS Guest: https://sabinehazanmd.com/ | https://x.com/SabinehazanMD | https://www.facebook.com/DoctorSabineHazan | https://www.instagram.com/dr.sabinehazan/ | https://www.linkedin.com/in/sabine-hazan-steinberg-md-5343b241/ | https://biomeboosters.com/ | https://progenabiome.com/ Host:  https://www.meredithforreal.com/  | https://www.instagram.com/meredithforreal/  | meredith@meredithforreal.com | https://www.youtube.com/meredithforreal  | https://www.facebook.com/meredithforrealthecuriousintrovert Sponsors: https://www.jordanharbinger.com/starterpacks/ | https://uwf.edu/university-advancement/departments/historic-trust/ 

Fecal transplants are an emerging new medical therapy that has been show to CURE cancer, Parkinson's, depression and anxiety, fibromyalgia, colitis and many more diseases both inside and outside of the gut. But this incredible (and kind of gross) procedure is taking the world by storm. It turns out that transplanting a healthy gut microbiome from one person to another can radically change their entire body, metabolism and even their personality.   TOPICS DISCUSSED: What fecal transplants are and how they work Diseases they can cure or mediate and why they're so effective How these came about (with some funchistory facts) Why they're so effective and how they work to alter your biology The benefits of FMT and how much it costs Safety vs efficacy  The potential doors this unlocks in the future   Leave us a Review: https://www.reversablepod.com/review   Need help with your gut? Visit my website gutsolution.ca to join a program: Get help now   Contact us: reversablepod.com/tips    FIND ME ON SOCIAL MEDIA: Instagram  Facebook  YouTube     Watch the Designer $hit documentary: Website: designershitdocumentary.com Watch the film: Buy or Rent   Studies on risks of FMT: PMC4986962

Fan Favorite: This episode originally aired on July 8, 2021. It's easy to quietly go through life never really facing yourself, your struggles and your fears. There is a solution to numb the pain of reality and move towards comfort where it's easier to accept things as they are no matter where you are. Mikhaila Peterson gracefully embodies the struggle of what it means to face yourself and all of your inadequacies and continue to push and explore through discomfort in pursuit of finding meaning while protecting what it means to be human, be a mother, be sexy and a successful business woman. SHOW NOTES: Accidental | Mikhaila talks about unplanned pregnancy at 23, career, & marriage [2:03] Anxiety & Chaos| Navigating stress from relationships and reducing chaos [7:17] Marriage | Mikhaila on the challenges of marriage before building foundation [10:12] Having Children | Is there a “right” time to have kids or only trade-offs to consider [14:54] Parenting Balance | How to balance an ambitious career and guilt free mothering [18:15] Criticism | Mikhaila on identifying where she could be wrong & being even keeled [25:28] Volatility | Mikhaila on how she's navigating her triggers and stress response [28:32] Self-Awareness | How Mikhaila began to notice her symptoms and reactions [33:18] Sex Appeal | Mikhaila on embracing her sex appeal and growing her business [38:12] Confidence | Having confidence & the borderline of being overly self conscious [51:12] Being Hardcore | What it takes to push self-limits and see what you can achieve [56:18] Having Impact | Mikhaila on getting “greedy” wanting to help many people [1:01:39] Pushing Limits | Finding balance to push too hard or being more reasonable [1:04:34] Burnout | Mikhaila on pushing through work you don't enjoy doing, outsourcing [1:10:18] Order & Chaos | Mikhaila on the navigating the balance of order and chaos [1:16:55] Discomfort | How to explore discomfort while building a brand vs. individual [1:19:46] Healthy Diets | Mikhaila on how she regulates diet chooses for her daughter [1:23:33] Carnivore Diet | Mikhaila on the benefits of an all beef diet on her body [1:29:00] FMT Experience | Mikhaila shares her experience with 10 FMT transplants [1:32:43] CHECK OUT OUR SPONSORS Vital Proteins: Get 20% off by going to ⁠https://www.vitalproteins.com⁠ and entering promo code IMPACT at check out Monarch Money: Use code THEORY at ⁠https://monarchmoney.com⁠ for 50% off your first year! Shopify: Sign up for your one-dollar-per-month trial period at ⁠https://shopify.com/impact⁠ Netsuite: Download the CFO's Guide to AI and Machine Learning at ⁠https://NetSuite.com/THEORY⁠ iTrust Capital: Use code IMPACTGO when you sign up and fund your account to get a $100 bonus at ⁠https://www.itrustcapital.com/tombilyeu⁠  Mint Mobile: If you like your money, Mint Mobile is for you. Shop plans at ⁠https://mintmobile.com/impact.⁠  DISCLAIMER: Upfront payment of $45 for 3-month 5 gigabyte plan required (equivalent to $15/mo.). New customer offer for first 3 months only, then full-price plan options available. Taxes & fees extra. See MINT MOBILE for details. ********************************************************************** LISTEN TO IMPACT THEORY AD FREE + BONUS EPISODES on APPLE PODCASTS:⁠ apple.co/impacttheory⁠ ********************************************************************** FOLLOW TOM: Instagram:⁠ https://www.instagram.com/tombilyeu/⁠ Tik Tok:⁠ https://www.tiktok.com/@tombilyeu?lang=en⁠ Twitter:⁠ https://twitter.com/tombilyeu⁠ YouTube:⁠ https://www.youtube.com/@TomBilyeu⁠ Learn more about your ad choices. Visit megaphone.fm/adchoices

Is the “poop pill” a possible treatment for small intestinal bacterial overgrowth (SIBO)? Pro-mask, pro-lockdown, pro-vax words come back to haunt their authors as Covid response critics appointed to key HHS positions; MAHA influencer Dr. Casey Means replaces original Surgeon General nominee; Rating Trump's new vaccine czar, oncologist Vinay Prasad; Is Laetrile effective for cancer? If you're eating a diet rich in fruits and vegetables, do you still need probiotics? Researchers tap an unusual source for antivenom against deadly snakebites—a snake handler who's survived multiple poisonings.

This episode features Dr. Gianluca Ianiro MD PhD, a gastroenterologist from the Fondazione A. Gemelli IRCCS and Università Cattolica del Sacro Cuore in Rome (Italy), speaking about how to advance gut microbiome testing for use in medicine. His interest in the gut microbiome began with the clinical observation that fecal microbiota transplantation (FMT) was remarkably […] The post Advancing gut microbiome testing for use in clinical practice, with Dr. Gianluca Ianiro MD PhD appeared first on International Scientific Association for Probiotics and Prebiotics (ISAPP).

Support your health journey with our private practice! Explore comprehensive lab testing, functional assessments, and expert guidance for your wellness journey. Find exclusive offers for podcast listeners at nutritionwithjudy.com/podcast. _____Dr. Neil and I dive into the complexity of the gut microbiome, challenging the notion that a single probiotic strain can fix everything. We explore how diversity—not one 'superbug'—may be the real key to gut health. We also unpack how fecal transplants work, why antibiotics often do more harm than good, and if fermented foods are necessary or ideal.Dr. Neil Stollman is a practicing gastroenterologist based in Oakland, California, and serves as voluntary faculty at UCSF. A pioneer in the field of fecal microbiota transplantation (FMT), he has been involved in gut microbiome research and treatment for over two decades. Known for his work with Clostridium difficile infection (CDI) and broader gut health issues, Dr. Stollman brings a balanced and often humorous perspective to microbiome science.We discuss the following:All about Dr. Neil StollmanThe importance of gut healthAll about AkkermansiaGlyphosate and other antimicrobial foodsFMT (Fecal Microbiota Transplantation)Getting sick from C. diff (Clostridioides difficile)Strengthening the MicrobiomeDo we need FermentsThoughts on giving antibiotics to people with C. diffSymptoms of H. pyloriThoughts on long-term PPI useWhy gut doctors prescribe PPIsThoughts on colon testsWhere to find Dr. Neil Stollman_____EPISODE RESOURCESWebsiteTwitterThe Sonnenburgs Fermented Food StudyOpenBiome (Stool Bank)NwJ Complete Wellness PanelComplete GI Map Stool Test_____WEEKLY NEWSLETTER 

Hospital-acquired c. diff infections—how to treat? Comparing ordinary dieting to intermittent fasting—which yields more weight loss? Metals from joint replacements may leak into brain; Why do seniors experience declines in their red blood cell counts? Weekend warriors rejoice—the equivalent amount of exercise crammed into two days equals mortality benefits of daily workouts; How to replenish low iron levels; Young anabolic steroid abusers risk premature heart problems.

Faecal transplant, also known as faecal microbiota transplantation or FMT, is the transfer of stool from a healthy donor to a patient with a disease. The idea is to restore the balance of bacteria in the gut, which can be disrupted by factors such as antibiotics, diet, or infection but it could potentially help with a range of problems from irritable bowel syndrome to Alzheimer's.  Why is faecal transplant used? How does faecal transplant work? How is faecal transplant performed? What are the risks of faecal transplant? In under 3 minutes, we answer your questions! To listen to the last episodes, you can click here: Could Britain ever rejoin the EU? What 5 foods can improve brain performance? What is pandemic skip? A podcast written and realised by Joseph Chance. First broadcast: 10/8/2023 Learn more about your ad choices. Visit megaphone.fm/adchoices

298 Dr Jason Hawrelak is a research scientist, educator, naturopath and Western herbalist with more than 18 years of clinical experience. Jason practices at Goulds Natural Medicine, a 136-year-old natural medicine apothecary and clinic located in central Hobart. He did his Honours and PhD degrees examining the causes of dysbiosis and the capacity of probiotics, prebiotics and herbal medicines to modify the gut microbiome and has written extensively in the medical literature on these topics – including 16 textbook chapters. He is on the Medical Nutrition Council of the American Society for Nutrition and was recently awarded a Fellowship from the American College of Nutrition for his significant contributions to the teaching and practice of nutrition in Australia and North America. Jason is also a Fellow of the Naturopaths and Herbalists Association of Australia. He is Chief Research Officer at ProbioticAdvisor.com, which offers a searchable database that enables easy, evidence-based prescribing of probiotic products and online resources for clinicians, and health-conscious members of the public, to learn more about the human microbiome and how they can positively influence these ecosystems. In this episode, we cover: What the faecal microbiome is made up of What faecal microbiota transplantation (FMT) is The history of FMT. Its use dates back to the 4th century in China and the 1950s Why it shows promise in inflammatory bowel disease Its impact on Parkinson's' disease and Alzheimer's The protocol/experience for patients and donors Jason's clinical experience with FMT and diet post-FMT The Healthy Gut Practitioner course (Naturopathic & Functional Medicine Approaches for GI Disorders Course). A course I am extremely excited to begin. See show notes for a special offer for the Love & Guts practitioner audience Show notes If you enrol in The Healthy Gut Practitioner course (Naturopathic & Functional Medicine Approaches for GI Disorders Course) using the following link https://tinyurl.com/yfy6kykp you will receive a free 1-year annual subscription to the Probiotic Advisor database and free access to one of Jason's other course Depression, Anxiety and the Gastrointestinal Tract Microbiota. Limited time offer only as there are only a few spaces available.    To access the free course, please email Helene (helene@probioticadvisor.com) after you enrol in The Healthy Gut Practitioner course (Naturopathic & Functional Medicine Approaches for GI Disorders Course). Helene will provide access to the Depression course and probiotics database as a bonus.   FMT Shop in the Netherlands discussed in the podcast   

In this episode of the Boost Your Biology podcast, Lucas Aoun interviews Dr. Adeel Khan, an expert in regenerative medicine and stem cell therapy. They discuss Dr. Khan's journey into the field, the limitations of conventional medicine, and the potential of regenerative therapies like platelet-rich plasma (PRP) and Muse stem cells. The conversation delves into the evolution of stem cell therapies, the mechanisms behind Muse cells, and the importance of complementary therapies to optimize health and healing. In this conversation, Adeel Khan and Lucas Aoun explore the themes of natural healing, mitochondrial function, and the role of peptides in health and longevity. They discuss how empowering the body's natural healing abilities can enhance health outcomes, the significance of mitochondrial function in aging, and the potential of peptides as a new frontier in supplementation. The conversation also delves into the importance of addressing chronic diseases, insulin sensitivity, and the accessibility of innovative therapies for proactive health management. They emphasize the need for better testing methods to understand mitochondrial dysfunction and the impact of trauma on weight loss efforts. In this conversation, Adeel Khan and Lucas Aoun delve into innovative approaches to gut health, including the use of peptides and fecal microbial transplants (FMT). They discuss the evolution of FMT technology, the interconnectedness of bodily systems through systems biology, and the importance of understanding immune system dynamics. The conversation highlights the need for updated health testing and the potential for targeted interventions to improve health outcomes. Adeel emphasizes the importance of educating doctors about these emerging therapies to enhance patient care.Relevant links:Dr. Adeel Khan's IG: https://www.instagram.com/dr.akhan/ Buy Lucas' NEW Herbal Supplement Here: https://www.inb4supps.com/ The information provided in this podcast episode is for entertainment purposes and is NOT MEDICAL ADVICE. The products presented and discussed in this podcast are explicitly only relevant to those who reside in the US. The statements and discussions held within this episode, are NOT approved by the TGA. If you have any questions about your health, contact a medical professional. This content is strictly the opinions of Lucas Aoun and is for informational and entertainment purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult with their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this content. All consumers of this content especially taking prescription or over-the-counter medications should consult their physician before beginning any nutritional, supplement or lifestyle program. Hosted on Acast. See acast.com/privacy for more information.

Several publications have described wondrous therapeutic effects of faecal microbiota transplant (FMT) on Clostridioides difficile infection. Yet the recent randomised trial assessing FMT in US veterans was terminated early for futility. In this episode, hosts Angela Huttner and Marc Bonten delve into the history, application, and complexities of FMT with experts Maria Vehreschild (Frankfurt University Hospital, Germany) and Dimitri Drekonja (Minneapolis Veteran Affairs Care System and University of Minnesota, US), who led the US trial. From the regulatory challenges and trial nuances to important new research, this conversation sheds light on a potentially revolutionary yet controversial treatment. Episode was edited by Kathryn Hostettler and peer-reviewed by Arjana Zerja (Mother Theresa University Hospital Centre, Tirana, Albania).Other mentions:EurFMTEuropean Directorate for the Quality of Medicines & HealthCare. Guide to the quality and safety of tissues and cells for human application. vol. 5th ed. EDQM Council of Europe; 2022. https://freepub.edqm.eu/publications/17/detail LiteratureDrekonja DM et al (2024) Clin Infect Dis, doi: 10.1093/cid/ciae467

Hi gang! Did someone order a podcast? Pretty sure you did. It's got your name on the delivery note. That's £12 please. Can't leave until you've paid me. FMT are back with more tales from the pixelated touchline. Join Rich, Dee and Jeb as they catch up on what's been going on in their virtual worlds this week. For the first time in a long time, we open up the FMT postbag and answer YOUR burning questions. Full English breakfasts, wonderkids, The Sims, time-travel, our favourite pod member. Nothing is off-limits (it is, we curated these questions very carefully) It's good to be back, ennit. Happy birthday, Steaky. VIVA LA FMT!

Hola! Hello! 'Ow do! Look who's back! FMT return with another episode about your favourite spreadsheet simulator. Join Rich, Dee and Steaky as they talk you through what's been going on in their digital worlds. On this weeks episode, the gang talk FM25 - we're due an update any minute now. NOW. ANY MINUTE. What are we hoping for? What do we want to see? When do we want it? Rich and Dee also test their ball knowledge on Steaky's FA Cup quiz and there's also far too much Thomas The Tank Engine chat. Or not enough. You decide. (Matt Berry's voice) VIVA LA FMT! Our links: linktr.ee/fmtpod

It's In the News.. a look at the top headlines and stories in the diabetes community. This week's top stories: Sana announces beta cell transplantation without the need for immunosuppresion drugs, Modular Medical teams up with Nudge BG for a brand new completely closed-loop system, the FDA moves forward to crack down on compounded Ozempic and Mounjaro, Dexcom and Abbott bury the legal hatchett for a while, and more.  Find out more about Moms' Night Out  Please visit our Sponsors & Partners - they help make the show possible! Learn more about Gvoke Glucagon Gvoke HypoPen® (glucagon injection): Glucagon Injection For Very Low Blood Sugar (gvokeglucagon.com) Omnipod - Simplify Life Learn about Dexcom  Edgepark Medical Supplies Check out VIVI Cap to protect your insulin from extreme temperatures Learn more about AG1 from Athletic Greens  Drive research that matters through the T1D Exchange The best way to keep up with Stacey and the show is by signing up for our weekly newsletter: Sign up for our newsletter here Here's where to find us: Facebook (Group) Facebook (Page) Instagram Twitter Check out Stacey's books! Learn more about everything at our home page www.diabetes-connections.com  Reach out with questions or comments: info@diabetes-connections.com Episode transcription with links:     Hello and welcome to Diabetes Connections In the News! I'm Stacey Simms and every other Friday I bring you a short episode with the top diabetes stories and headlines happening now. XX Big news from Sana Biotechnology. Their first in human study of islet cells without any immunosuppression appears to be a success. This is very early and hasn't yet been peer reviewed and published.. but after four weeks, there were no safety issues and the transplanted beta cells were producing insulin. Sana's CEO says  “As far as we are aware, this is the first study showing survival of an allogeneic transplant with no immunosuppression or immune-protective device in a fully immune competent individual. Safe cell transplantation without immunosuppression has the potential to transform the treatment of type 1 diabetes and a number of other diseases.”   I've reached out to Sana to get more on this.. love to talk to them soon.   https://www.bakersfield.com/ap/news/sana-biotechnology-announces-positive-clinical-results-from-type-1-diabetes-study-of-islet-cell/article_d0390fd6-99cb-53bd-b04d-9337121e01bf.html XX FDA says no for sotagliflozin as an adjunct to insulin therapy for glycemic control in adults with type 1 diabetes (T1D) and chronic kidney disease (CKD).  Studies showed a meaningful reduction in A1C but a meaningful increase in DKA. The FDA first rejected this in 2019 and was resubmitted last summer. But The advisory committee voted 11 to 3 against the approval of sotagliflozin stating that the benefits of sotagliflozin do not outweight the risks in adults with T1D and CKD. Sotagliflozin is currently approved under the brand name Inpefa to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with 1) heart failure; or 2) type 2 diabetes mellitus, CKD, and other cardiovascular risk factors.  According to Lexicon, Inpefa will continue to be manufactured and made available to patients. https://www.renalandurologynews.com/news/fda-denies-approval-of-zynquista-for-type-1-diabetes-and-ckd/ XX Two companies we've been following are teaming up.. Modular Medical has an FDA clear patch pump and Nudge BG has an adaptive full closed loop. They've announced a new partnership agreement. From the release: Modular Medical's easy-to-use and cost-effective MODD1 insulin pump technology. Our combined system is intended to nudge blood glucose by making small changes to insulin delivery based on estimated glucose inputs from a continuous glucose monitor." Familiar name to some of you, Lane Desborough is the founder of Nudge BG. He says this will be a fully automated system, no mealtime bolusing needed.   https://www.accesswire.com/957703/modular-medical-announces-licensing-and-partnership-agreement-with-nudge-bg XX Beta Bionics filed for an initial public offering on Monday. The company did not disclose the number of shares it will offer or the price range. Beta Bionics plans for shares to be listed on the Nasdaq under the ticker symbol “BBNX.” The Irvine, California-based company makes an insulin pump called the iLet Bionic Pancreas, which was cleared by the Food and Drug Administration in 2023. Beta Bionics plans to use the proceeds to grow its sales and manufacturing infrastructure and develop new features for its device.   https://www.medtechdive.com/news/beta-bionics-insulin-pump-files-ipo/736805/     XX Tandem Diabetes Care, Inc. signed a multi-year collaboration agreement with the University of Virginia Center for Diabetes Technology (UVA) to advance research and development efforts on fully automated closed-loop insulin delivery systems.   There's a long history here – UVA is where the Control IQ algorithm was developed.  This agreement seems to keep the team together for another decade. https://www.businesswire.com/news/home/20250107162995/en/Tandem-Diabetes-Care-Enters-Multi-Year-Research-Collaboration-with-UVA-Center-for-Diabetes-Technology-for-Development-of-Advanced-Insulin-Delivery-Systems XX New study says insulin is still the best treatment for gestational diabetes, compared to oral glucose-lowering medications. Metformin and gluburide are being closely looked at since they're easier to administer, less costly, and have better acceptance among patients. But this study says insulin was a bit better – slight more babies were born larger for the metformin group, and more moms had hypoglycemia. https://www.medpagetoday.com/obgyn/pregnancy/113651 XX In its Citizen Petition to the FDA, Novo Nordisk argued that there is no clinical need to allow compounding for liraglutide, the type 2 diabetes injection it sells as Victoza. Novo Nordisk last month filed a Citizen Petition with the FDA asking the federal agency to exclude its type 2 diabetes injection Victoza (liraglutide) from a proposed list of drugs eligible for compounding. https://www.biospace.com/fda/novo-launches-citizen-petition-to-block-compounded-victoza XX Bit of an update on compounded terzepatide and semaglutide. The FDA is allowing a grace period of 60 days before starting to enforce the end of allowing compounds of Mounjaro. Meanwhile, semaglutide remains on the FDA's shortage list for several dose strengths, though all doses have been reported as “available” since late October 2024. Compounding pharmacies, especially larger 503B “outsourcing facilities,” maintain they provide an essential public service by offering lower-cost versions of medications that can cost over $1,000 per month. Many insurers still refuse to cover brand-name GLP-1 products for weight loss. Yet  the FDA has reported hundreds of adverse event reports allegedly linked to compounded versions of these drugs, which do not undergo the same rigorous manufacturing inspections and clinical testing as approved brands.   https://www.drugdiscoverytrends.com/compounders-and-drugmakers-clash-over-compounded-weight-loss-drugs-with-fda-in-the-middle/ XX Interesting story here.. this study says a fecal transplant can help people with type 1 and severe gastroenteropathy. The researchers say diabetic gastroenteropathy commonly affects individuals with type 1 diabetes, causing debilitating symptoms like nausea, vomiting, bloating, and diarrhea; however, treatment options remain limited. Researchers conducted a novel clinical trial to test the benefits of FMT in adult patients with type 1 diabetes and severe symptoms of gastroenteropathy, who were randomly assigned to receive either FMT or placebo capsules as the first intervention. After four weeks, Compared with placebo, FMT led to significant changes in the diversity of the gut microbiome. https://www.medscape.com/viewarticle/fmt-shows-early-success-type-1-diabetes-bowel-issues-2025a10000bg XX A couple of weeks ago, listeners told me that the Dexcom geofencing issue we reported on seems to be resolved. Dexcom is now confirming this. Previously, if you had an issue with Dexcom G7 outside of your home country, you couldn't reinstall or use the app without customer support. As of last month, the geofencing issue has now been resolved with the latest Dexcom G7 2.6 app update. Can I travel with my Dexcom G7? | Dexcom XX Abbott and Dexcom settled all patent lawsuits related to continuous glucose monitors (CGMs). The two competitors, who lead the U.S. market for CGMs, agreed on Dec. 20 to resolve all outstanding patent disputes and not sue each other over patents for 10 years.   Dexcom and Abbott previously reached a settlement in 2014 related to their diabetes devices, which included a cross-licensing deal and an agreement not to sue each other until 2021. After that agreement expired, the companies filed a volley of patent lawsuits. https://www.medtechdive.com/news/abbott-dexcom-settle-cgm-patent-lawsuits/736300/  

Happy bloody New Year gang! It's 2025 and FMT are back - fighting fit and ready to podcast! Join Rich, Dee and Jeb as they talk you through what's been going on in their virtual worlds this week. On this episode, the gang get introspective. New Year means resolutions and the gang have loads of them - some FM-based, some not so FM based. We won't spoil anything here, but we will say this - Rich seems to bloody LOVE Elden Ring. It's good to be back. VIVA LA FMT! Our links: linktr.ee/fmtpod

“Fecal microbial transplants” treat someone's unhealthy gut with poop from someone else's healthy gut, and proponents of FMT claim it can help treat everything from IBS to autism. But if your doctor isn't ready to fill you up with someone else's poop, the internet will happily oblige.  Guest:  Luke Winkie, Slate staff writer who published “The Poop Broker.” Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Disclosure in Podcast Description: A Bond Account is a self-directed brokerage account with Public Investing, member FINRA/SIPC. Deposits into this account are used to purchase 10 investment-grade and high-yield bonds. As of 9/26/24, the average, annualized yield to worst (YTW) across the Bond Account is greater than 6%. A bond's yield is a function of its market price, which can fluctuate; therefore, a bond's YTW is not “locked in” until the bond is purchased, and your yield at time of purchase may be different from the yield shown here. The “locked in” YTW is not guaranteed; you may receive less than the YTW of the bonds in the Bond Account if you sell any of the bonds before maturity or if the issuer defaults on the bond. Public Investing charges a markup on each bond trade. See our Fee Schedule. Bond Accounts are not recommendations of individual bonds or default allocations. The bonds in the Bond Account have not been selected based on your needs or risk profile. See https://public.com/disclosures/bond-account to learn more. Learn more about your ad choices. Visit megaphone.fm/adchoices

“Fecal microbial transplants” treat someone's unhealthy gut with poop from someone else's healthy gut, and proponents of FMT claim it can help treat everything from IBS to autism. But if your doctor isn't ready to fill you up with someone else's poop, the internet will happily oblige.  Guest:  Luke Winkie, Slate staff writer who published “The Poop Broker.” Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Disclosure in Podcast Description: A Bond Account is a self-directed brokerage account with Public Investing, member FINRA/SIPC. Deposits into this account are used to purchase 10 investment-grade and high-yield bonds. As of 9/26/24, the average, annualized yield to worst (YTW) across the Bond Account is greater than 6%. A bond's yield is a function of its market price, which can fluctuate; therefore, a bond's YTW is not “locked in” until the bond is purchased, and your yield at time of purchase may be different from the yield shown here. The “locked in” YTW is not guaranteed; you may receive less than the YTW of the bonds in the Bond Account if you sell any of the bonds before maturity or if the issuer defaults on the bond. Public Investing charges a markup on each bond trade. See our Fee Schedule. Bond Accounts are not recommendations of individual bonds or default allocations. The bonds in the Bond Account have not been selected based on your needs or risk profile. See https://public.com/disclosures/bond-account to learn more. Learn more about your ad choices. Visit megaphone.fm/adchoices

Have you ever been told to "get your head out of the ozone" or accused of being "full of...well, you know"? This week's Fur Real episode flips those phrases on their heads in the most fascinating way! We're thrilled to welcome the legendary Dr. Margo Roman, a renowned veterinarian and a pioneer in Ozone Therapy and Fecal Microbiota Transplantation (FMT). Join us as Dr. Roman takes us on an eye-opening journey through the history and remarkable benefits of these groundbreaking therapies. Discover the cutting-edge tools hiding in the veterinary toolbox and learn how they can revolutionize the way you care for your furry companions. Dr. Roman's expertise is as enlightening as it is practical—you won't want to miss a second of this transformative conversation. Your pet's health (and maybe your curiosity) will thank you! www.furrealpodcast.com         www.mashvet.com      www.mbrt.life ig @thefurrealpodcast      @mainstanimalservices Speical thanks to J Jig Cicero @jjigcicero for our music intro and outro..you rock!!! Special thanks to Jake Olson  jfolson.music@gmail.com for awesome sound editing  and to our supporters: www.prepvet.com  Stem cells for pets

If you're watching your child struggle despite trying everything the conventional medical system has to offer, this episode could change everything. In this episode, I continue the conversation with Miriam Gimal (make sure to listen to part 1 first), who's revolutionizing autism treatment through your child's gut health. If you've noticed your child's symptoms getting worse despite traditional interventions, or if you're frustrated by treatments that only mask the symptoms, this conversation will open your eyes to what's really going on beneath the surface. You'll discover why your child's diet might be the key you've been missing, and how simple changes could lead to breakthrough improvements. Miriam shares her innovative "Ret Rot Ret" protocol—a practical approach that's helping parents just like you identify hidden triggers and reduce inflammation naturally. Whether you're new to the autism journey or have tried everything else, this episode will equip you with actionable strategies that go beyond traditional behavioral therapy. From groundbreaking treatments like FMT to practical dietary changes you can start today, you'll learn why the gut-brain connection could be the missing piece in your child's wellness puzzle. Join us to discover how parents around the world are finding new hope through holistic approaches that address the root cause of autism symptoms. Your path to helping your child thrive starts here. 00:00 Introduction 03:00 Miriam Jamal's Journey and the Power of Mothers 06:00 Challenges in Recognizing Autism Symptoms 09:00 Discovering Key Interventions in Panamá 12:00 The Role of the Microbiome in Autism 15:00 Identifying Hidden Infections and Immune System Deficits 18:00 Health as Layers: Addressing the Root Cause 21:00 The Role of Food and Diet in Recovery 24:00 Red, Rot, Red: A Rotating Diet Strategy 27:00 The Truth About Stem Cells and Inflammation 30:00 Fecal Microbiota Transplants (FMT): The Holy Grail 33:00 Building a Comprehensive Protocol in Panamá 36:00 Not Just Autism: Broader Applications 39:00 Overcoming Medical Barriers and Taking Action 42:00 Final Words: Diagnosis Is Not a Prognosis   Check us out on social media: drefratlamandre.com/instagram drefratlamandre.com/facebook drefratlamandre.com/tiktok   Check out Miriam's social media:  Miriam Gimal IG user: @miriam_gimal  link: drefratlamandre.com/miriamig   The ABC for Autism user: @theabc4autism  Link: drefratlamandre.com/abc4autismig     

Hi gang! Hope you're well! FMT are back with more hot podin' for your eyes and ears. Join Rich, Jeb, Dee and Steaky as they talk you through what's been going on in their virtual worlds. On this weeks episode, the gang take you all the way back to the crazy days of... um... 2022 actually. Football Manager PVP was booming. Everybody wanted to be involved. But by the end of FM 2023, the game mode had died a death. We ask the big question: why? We also discover how incredibly well balanced we are as people as we discuss FM superstitions and Steak brings a new triva round to the party. SPOILER: Rich doesn't do very well. VIVA LA FMT! Our links: linktr.ee/fmtpod

Are you dealing with persistent diarrhea? Have you tested for or considered testing for C. Difficile (c.diff)? Gastroenterologist and c.diff expert Dr. Neil Stollman stops by the podcast to discuss testing for c.diff, how to heal, and Fecal Microbiota Transplant (FMT) options for common gut conditions. Learn more, watch now!  

How knowledgeable are you about the gastrointestinal microbiome? This complex and crucial community of microorganisms—including bacteria, viruses and fungi—live within an animal's body and is essential for digestion, immune system regulation, energy metabolism and more. Tune in to this insightful VetFolio Voice podcast episode and learn about the role of the gut microbiome on body systems, GI disease and weight management, plus find out how nutrition, nutritional support and fecal microbiota transplantation (FMT) influence it.

OH BOY! This has the potential to be special. For the first time ever, join THE ENTIRE FMTeam as they play arguably Rich's greatest ever creation: FMT-askmaster! The boys were set the task of completing one season in Germany managing Wolfsburg with some special challenges set by Rich (and helped in judgement by his right hand man "Little" Jebaroo) How did they get on? You'd better watch and find out. Stop reading. Start experiencing history. VIVA LA FMT! Our links: linktr.ee/fmtpod

Hi friends! Welcome back! We've missed you all terribly. FMT is back with another burning hot bowl of podcasting. This week, join Rich, Dee & Steaky as they talk you through what's been going on in their virtual worlds this week. On today's episode, we ask a question it feels like we haven't asked in a hot minute - how are you? With pod newbies Dee and Steak in the hotseat, we take the time to focus on the T in FMT and get to know the twins a little better and check in with our new pals. It's good to talk. We also find out more about Rich's misjudged decision to move to a depleted Juventus side, and flex our incredible ball knowledge with a little bit of very specific quizzing. This is a very nice episode where three very nice boys talk to eachother about slightly serious things, and that's a nice thing to do with friends. Give it a go. VIVA LA FMT! VIVA FRIENDS. Our links: linktr.ee/fmtpod

Ahoy there podcast boodarinos! FMT are back with another brand new episode! Join the brand new podcast rotation of Rich, Callum & Steak (hereafter known as Team Silly Goose) as they talk you through what's been going on in their virtual worlds. You've all heard of Barclaysmen, no? Well, this week FMT introduce you to the concept of Savesmen - players who encapsulate the quintessential FM experience. Rich, Callum and Steak have a good reminisce about their FM24 journeys and the players that made it special. Club legends or lads that were with them for a good time, not a long time - they all make the cut. Callum also brings a new feature to the table: Sausage Roles. Context only slows that one down. VIVA LA FMT! Our links: linktr.ee/fmtpod

Send us a textLess than 2 years ago, you'd likely never heard of GLP-1 mediations. Today, it's on the tip of everyone's tongue as the solution to weight management, has longstanding organizations like Weight Watchers on the verge of bankruptcy and is making employee benefits coverage for employers more difficult than ever due to the cost. How does it work? Why are so many people talking about it? What are the potential dangers? And are there safe, smart ways to proceed down this path?We are extremely fortunate today to have physician Dr. Sheri Poznanovic and nationally board-certified health & wellness coach Erin Chain join us on today's episode of The Coaching Lab podcast. Known as Dr. Sheri, Poznanovic is triple board certified in Nutrition, Lifestyle, and Obesity Medicine. After more than 15 years as a practicing pediatric ENT surgeon in Colorado, her career focus shifted to lifestyle, wellness, and nutrition counseling. She also has a Master of Science degree in Nutrition and Human Performance, and has had her work published in peer-reviewed journals. She is the founder of Optin Health & Nutrition, a comprehensive nutrition & lifestyle medicine practice in Colorado. Contact Optin via pozmd@optin4health.com or (303) 495-9013Erin Chain is a physical therapist and nationally board certified health & wellness coach. She works with Dr. Sheri on the lifestyle management side of the equation and brings an exceptional background to the table. For details about the functional mental toughness specialty certification, please see: https://www.catalystcoachinginstitute.com/education/specialty-certifications/OptIn is a comprehensive nutrition and lifestyle medicine practice focused on helping individuals reclaim their nutritional well-being and heighten their human performance through healthier living.  Whether you're seeking help with disease prevention and management, weight loss, or sports nutrition, OptIn's approach is always Optimized and Individualized to each client's needs.Erin is thrilled to discuss the use of Dr Brad Coopers FMT Model with coaches that are interested- please reach out to her at erin@catalystcoaching360.com- She is happy to set up a 15 minute complimentary call with coaches interested in incorporating the FMT model into their practice or patients interested  in learning more about Optin and the services we provide!Looking for weekly tips, tricks and turbo boosts to enhance your life? Sign up for the CATALYST COMPASS here, a brief weekly compilation of ideas, evidence-based concepts and encouragement to improve your personal and professional life! Info re earning your health & wellness coaching certification, annual Rocky Mountain Coaching Retreat & Symposium & more via https://www.catalystcoachinginstitute.com/ Best-in-class coaching for Employers, EAPs & wellness providers https://catalystcoaching360.com/ YouTube Coaching Channel https://www.youtube.com/c/CoachingChannel Contact us: Results@CatalystCoaching360.comTwitter: @Catalyst2ThriveWebsite: CatalystCoaching360.comIf you are a current or future health & wellness coach, please check out our Health & Wellness Coaching Community on Facebook: https://www.facebook.com/groups/278207545599218. This is a wonderful group if you are looking for encouragement, ideas, resources and more.

Fecal transplants are saving cancer patients at MD Anderson? In this episode of Docs Talk Shop, Dr. Gordon and I explore how a major breakthrough in microbiome science could open up new treatment possibilities for cancer patients.But the news is not all good--fecal transplants can also transfer obesity. We discuss how a patient who received an FMT from an obese donor gained weight, highlighting just how powerful and influential the microbiome is in regulating metabolism.We discuss the remarkable ability of bariatric surgery ("stomach stapling," for obesity) to resolve type 2 diabetes in just a few days—long before any weight loss occurs, and the mind-boggling reason for this counterintuitive occurrence.Lifting weights is better than psychotherapy? Believe it or not, resistance training is found to be 1.5 times more effective than medication or talk therapy for treating anxiety and depression. And also in the realm of psychiatry, we explore Morgellon's disease. Patients with this condition report colorful fibers growing from their skin. Long considered a psychiatric disorder with delusions, (a misdiagnosis that has confined patients wrongly to inpatient mental health institutions) recent research finds a link between the colorful fibers of Morgellon's and Lyme disease.Join us as we explore unexpected solutions to the toughest health challenges.References:Morgellons disease psychiatric condition or spirochetal infection? National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8647328/. Accessed September 24, 2024.Morgellons disease linked to infection. Dove Press. https://www.dovepress.com/getfile.php?fileID=69133. Accessed September 24, 2024.Links between Morgellons and Lyme disease. LymeDisease.org. https://www.lymedisease.org/links-morgellons-lyme-disease/. Accessed September 24, 2024.NAC alleviates OCD behaviors: Skin-picking, trichotillomania, etc. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10909310/. Accessed September 24, 2024.The nucleus accumbens and its role in reward, addiction, and pain. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975138/. Accessed September 24, 2024.Defecation increases athletic performance by increasing brain oxygenation. PubMed. https://pubmed.ncbi.nlm.nih.gov/37102434/. Accessed September 24, 2024.Bariatric surgery decreases breast cancer risk. MDedge. https://ma1.mdedge.com/obgyn/article/269409/breast-cancer/bariatric-surgery-may-reduce-breast-cancer-risk-some?ecd=WNL_EVE_240603_mdedge. Accessed September 24, 2024.Infectious agents and cancer. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10964319/. Accessed September 24, 2024.Infectious agents including SARS-CoV-2 linked to cancer. Frontiers. https://www.frontiersin.org/articles/10.3389/fcell.2022.8761Dawn Lemanne, MD Oregon Integrative OncologyLeave no stone unturned.Deborah Gordon, MDNorthwest Wellness and Memory CenterBuilding Healthy Brains

Send us a textThis special episode features a real, live coaching session with NBHWC nationally board-certified coach Sabryna Liddle, who has also earned her specialty certification in functional mental toughness & resilience (fMTc). Following the coaching session (session #2 with this client), Sabryna and Dr. Cooper will provide a debrief discussion for coaches who are curious about some of the specific elements of the fMT skills and how they were utilized throughout the coaching session.For details about the specialty certification in functional mental toughness & resilience, please see https://www.catalystcoachinginstitute.com/education/specialty-certifications/Looking for weekly tips, tricks and turbo boosts to enhance your life? Sign up for the CATALYST COMPASS here, a brief weekly compilation of ideas, evidence-based concepts and encouragement to improve your personal and professional life! Info re earning your health & wellness coaching certification, annual Rocky Mountain Coaching Retreat & Symposium & more via https://www.catalystcoachinginstitute.com/ Best-in-class coaching for Employers, EAPs & wellness providers https://catalystcoaching360.com/ YouTube Coaching Channel https://www.youtube.com/c/CoachingChannel Contact us: Results@CatalystCoaching360.comTwitter: @Catalyst2ThriveWebsite: CatalystCoaching360.comIf you are a current or future health & wellness coach, please check out our Health & Wellness Coaching Community on Facebook: https://www.facebook.com/groups/278207545599218. This is a wonderful group if you are looking for encouragement, ideas, resources and more.

In this enlightening episode of the Tick Boot Camp Podcast, hosts Matt Sabatello and special guest co-host Justin Lindorf sit down with Dr. Andrew Petersen, a Lyme-literate medical doctor with over 24 years of experience in treating chronic Lyme disease and other complex chronic illnesses. Dr. Petersen shares his unique journey into medicine, driven by a desire to "stick up for the little guy," and how he transitioned from family medicine to becoming a leading figure in Lyme disease treatment. Key Takeaways: Creating a Healing Environment: Dr. Petersen emphasizes that the key to overcoming chronic Lyme disease is creating an environment where the body can make more new cells than are being broken down, which promotes overall health and healing. Promoting Cell Growth and Repair: Ingredients for New Cell Formation: Ensuring the body has the necessary fats, proteins, carbohydrates, vitamins, minerals, oxygen, and water. Proper Signaling Molecules: Maintaining the presence of hormones, peptides, cytokines, interleukins, enzymes, growth factors, and neurotransmitters. Optimizing Cell Production: Addressing hormone and thyroid imbalances to enhance the body's ability to make new cells. Reducing Cell Death: Managing Microbes: Implementing strategies to reduce the microbial load, including Lyme-specific treatments and immune support. Detoxification: Actively managing and reducing environmental and internal toxins that contribute to cellular breakdown. Addressing Stress and Trauma: Implementing therapies to reduce the impact of psychological and physical trauma, which can trigger immune dysfunction. Mitigating Electromagnetic Frequencies: Reducing exposure to EMFs, which can disrupt cellular function and contribute to chronic illness. Fecal Implants and Microbiome Health: Dr. Petersen discusses the use of ThaenaBiotic, a processed and sterilized form of fecal microbiota transplant (FMT), to help restore a healthy microbiome. This approach aims to reintroduce beneficial bacteria to the gut, which can be crucial for patients with Lyme disease and other chronic conditions. Dr. Petersen's Journey: Learn about Dr. Petersen's unconventional path to becoming a DO, inspired by personal experiences and a dynamic biology professor. Understanding DO vs. MD: Dr. Petersen explains the differences between DOs (Doctors of Osteopathic Medicine) and MDs, and why he chose the osteopathic path. Challenges in Lyme Diagnosis: Dr. Petersen discusses the difficulties he faced in diagnosing Lyme disease during his early career, especially while working in tick-endemic areas without proper awareness or training. Integrative Approach to Healing: Dr. Petersen shares his holistic approach to treating Lyme disease, which includes addressing the key factors that contribute to chronic illness alongside Lyme-specific treatments. Justin Lindorf's Perspective: As a Lyme patient himself, Justin offers valuable insights into Dr. Petersen's compassionate and open-minded approach to patient care. Subscribe: Don't miss out on future episodes! Subscribe on Apple Podcasts or your favorite podcast platform. Join the Conversation: Have thoughts on this episode? Share your comments and questions with us on social media, or join our online community for ongoing discussions.

Not one of us are completely immune to an occasional episode of diarrhea. Whether you can trace it back to something you ate or an up tick in stress, liquid poop is not ideal. Kate and Megan are joined by a giant in the field of gastroenterology, Dr. Jessica Allegretti from Brigham & Women's Hospital in Boston, Massachusetts to do a deep dive discussion into diarrhea. Together, they discuss the various causes of diarrhea, from common infections and food intolerances to more chronic conditions like irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). Dr. Allegretti offers valuable insights into the concerns surrounding Clostridium difficile (C. diff) infections and the complexities involved in diagnosing and treating recurrent cases. We also explore cutting-edge research of live biotherapeutic products (LBPs) and their promising role in the innovative area of fecal microbiota transplantation (FMT) with the guidance of this world-renowned expert.  And, we couldn't discuss diarrhea without acknowledging the potential role of food, stress and the intricate relationship between our gut microbiome and our behaviors. Kate and Megan provide practical tips and tricks to the nutritional and behavioral management of this often times anxiety provoking symptom that leave all listeners feeling empowered with strategies when it comes to the runs. Whether you've had C.Diff, are managing IBS-D or just curious about this common symptom this episode is a must listen!  Tune in for practical insights and valuable strategies to improve your well-being and gut health. Read more: Diagnosis and Management of Clostridioides difficile Infection in Patients with Inflammatory Bowel DiseaseYale Medicine: C. Diff Infection overviewApproach to the Patient with Diarrhea and MalabsorptionLow FODMAP toolsDiaphragmatic breathing (video by Dr. Megan Riehl)Learn more about Kate and Dr. Riehl:Website: www.katescarlata.com and www.drriehl.comInstagram: @katescarlata @drriehl and @theguthealthpodcastOrder Kate and Dr. Riehl's book, Mind Your Gut: The Science-Based, Whole-body Guide to Living Well with IBS. The information included in this podcast is not a substitute for professional medical advice, examination, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider before starting any new treatment or making changes to existing treatment.

“Fecal microbial transplants” treat someone's unhealthy gut with poop from someone else's healthy gut, and proponents of FMT claim it can help treat everything from IBS to autism. But if your doctor isn't ready to fill you up with someone else's poop, the internet will happily oblige.  Guest:  Luke Winkie, Slate staff writer who published “The Poop Broker.” Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

“Fecal microbial transplants” treat someone's unhealthy gut with poop from someone else's healthy gut, and proponents of FMT claim it can help treat everything from IBS to autism. But if your doctor isn't ready to fill you up with someone else's poop, the internet will happily oblige.  Guest:  Luke Winkie, Slate staff writer who published “The Poop Broker.” Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

“Fecal microbial transplants” treat someone's unhealthy gut with poop from someone else's healthy gut, and proponents of FMT claim it can help treat everything from IBS to autism. But if your doctor isn't ready to fill you up with someone else's poop, the internet will happily oblige.  Guest:  Luke Winkie, Slate staff writer who published “The Poop Broker.” Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

“Fecal microbial transplants” treat someone's unhealthy gut with poop from someone else's healthy gut, and proponents of FMT claim it can help treat everything from IBS to autism. But if your doctor isn't ready to fill you up with someone else's poop, the internet will happily oblige.  Guest:  Luke Winkie, Slate staff writer who published “The Poop Broker.” Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

“Fecal microbial transplants” treat someone's unhealthy gut with poop from someone else's healthy gut, and proponents of FMT claim it can help treat everything from IBS to autism. But if your doctor isn't ready to fill you up with someone else's poop, the internet will happily oblige.  Guest:  Luke Winkie, Slate staff writer who published “The Poop Broker.” Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

“Fecal microbial transplants” treat someone's unhealthy gut with poop from someone else's healthy gut, and proponents of FMT claim it can help treat everything from IBS to autism. But if your doctor isn't ready to fill you up with someone else's poop, the internet will happily oblige.  Guest:  Luke Winkie, Slate staff writer who published “The Poop Broker.” Want more What Next TBD? Subscribe to Slate Plus to access ad-free listening to the whole What Next family and all your favorite Slate podcasts. Subscribe today on Apple Podcasts by clicking “Try Free” at the top of our show page. Sign up now at slate.com/whatnextplus to get access wherever you listen. Learn more about your ad choices. Visit megaphone.fm/adchoices

View the Show Notes Page for This Episode Become a Member to Receive Exclusive Content Sign Up to Receive Peter's Weekly Newsletter Colleen Cutcliffe is an expert in molecular biology and co-founder of Pendulum Therapeutics, a company working to develop treatments for a variety of diseases by targeting the microbiome. In this episode, Colleen delves into the complexity of the microbiome, how it is tested, and how it changes over time. She explores how probiotics, prebiotics, and postbiotics affect the gut and makes a compelling case that well-developed products have the potential not only to enhance gut health but also to positively influence overall metabolic well-being. Colleen emphasizes the significance of a high-fiber diet in sustaining a thriving gut microbiome, shares insights on minimizing microbiome damage during antibiotic use, provides tips for fostering and preserving a healthy gut, and much more. We discuss: Colleen's background and current focus [4:45]; The basics of the microbiome [7:15]; The study of the human microbiome [15:15]; Categories of bacteria, and the implications on health of the rapid evolution of bacteria [19:45]; Methods for measuring and understanding the microbiome, and key indicators of microbiome health [28:30]; The important role of fiber for promoting gut health through the production of butyrate [38:30]; The case for manipulating gut bacteria via fecal microbiota transplant (FMT) [45:00]; Dynamics of the microbiome: the gut-brain connection and how antibiotics, nutrition, stress, and more impact the microbiome's diversity and function [50:15]; Factors that influence the vaginal microbiome [55:15]; The effect of gut microbes on obesity and challenges with fecal transplants in people [58:45]; Beneficial strains of gut bacteria and strains commonly found in probiotics [1:01:15]; The difference between a probiotic and prebiotic, and how CFUs are a measure of the “active ingredient” [1:09:45]; Considerations about how probiotic strains are produced, and more on the meaning of CFU [1:14:15]; Mitigating the effect of antibiotics on the microbiome [1:22:30]; What do we know about the effect of artificial sweeteners on the gut microbiome? [1:30:00]; Why Akkermansia is a keystone strain with implications for metabolic health and an individual's response to dietary interventions [1:36:15]; The essential steps necessary to develop a robust probiotic for optimal health support [1:45:45]; How Akkermansia helps control blood glucose, and potential implications of Akkermansia in weight loss, diabetes management, and more [1:48:45]; Pendulum Therapeutics' commitment to rigorous product develop [2:06:30]; Details about the probiotic “Glucose Control” and other probiotics developed by Pendulum Therapeutics [2:13:00]; Further studies of Akkermansia that have been proposed or are underway [2:20:30]; and More. Connect With Peter on Twitter, Instagram, Facebook and YouTube