Pharmacology Daily

Antidepressants demonstrate modest but real benefits for moderate-to-severe depression, with large meta-analyses showing consistent advantages over placebo and meaningful improvements in function for many patients, yet these gains are often smaller than portrayed and heavily influenced by high placebo responses.
The evidence base comes with important limitations, including publication bias, short trial durations, industry influence, and challenges in blinding, which can inflate perceived efficacy while understating long-term risks such as sexual dysfunction, emotional blunting, and weight gain reported more frequently in real-world surveys.
Navigating antidepressants requires pragmatic humility: they are a valuable tool for the right person at the right time when used with careful monitoring, deprescribing when appropriate, and combined with therapy and lifestyle changes, rather than as a one-size-fits-all solution or something to fear outright.