Podcasts about Naltrexone

Naltrexone is often a first-line medication for AUD. It works as an opioid receptor antagonist, reducing the rewarding effects of alcohol and decreasing cravings. Patients frequently report that alcohol becomes less pleasurable while taking the medication. Oral naltrexone is typically dosed at 50 mg daily, while a long-acting injectable formulation is also available. Avoid use in patients taking opioids and use caution in significant liver dysfunction. Acamprosate helps maintain abstinence by modulating glutamate and GABA neurotransmission. Chronic alcohol use disrupts the balance between excitatory and inhibitory pathways in the brain, and acamprosate helps restore equilibrium. It is primarily eliminated renally, making it a useful option in patients with liver disease. The most common adverse effect is diarrhea. Disulfiram works through a completely different mechanism. It inhibits aldehyde dehydrogenase, causing acetaldehyde accumulation when alcohol is consumed. This can lead to flushing, nausea, vomiting, headache, and hypotension. Because of this aversive reaction, patient motivation and adherence are critical for success. Be sure to check out our free Top 200 study guide – a 31 page PDF that is yours for FREE! Support The Podcast and Check Out These Amazing Resources! NAPLEX Study Materials BCPS Study Materials BCACP Study Materials BCGP Study Materials BCMTMS Study Materials Meded101 Guide to Nursing Pharmacology (Amazon Highly Rated) Guide to Drug Food Interactions (Amazon Best Seller) Pharmacy Technician Study Guide by Meded101

FILM FEST TIX: https://buytickets.at/thedopeyfoundation/2216905 PATREON: www.patreon.com/dopeypodcast workithealth.com/dopey This week on Dopey Wednesday,! We begin with a Father's Day rant about dads texting each other, calls his father Alan live on the show, argues about masculinity, the Knicks championship, post-Knicks withdrawal, the Dopey Film Festival, and whether Seymour is allowed to come. Dave also reads Patreon and Spotify comments about Todd's sister Allie, Todd's apartment, Dopey socks, and listener reactions. Then the episode shifts into a live Workit Health/Dopey event with the great Amy “Dopey Dres” Dresner, author of My Fair Junkie. Amy talks brutally and hilariously about long-term recovery when life does not magically become beautiful: losing her father, mother, and cat in a short period of time, checking herself into a psych ward with ten years sober, surviving suicidal ideation, epilepsy, seizures, brain meds, isolation, grief, and the nightmare comedy of American healthcare. Dave and Amy get into harm reduction, MAT, 12-step recovery, writing through trauma, being funny in the middle of misery, shame, forgiveness, isolation, suicidal thoughts, and why connection is still the only real way out. It's classic Dopey: funny, dark, honest, messy, sad, useful, and somehow hopeful. All that and more on a weird new dopey! Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.

Dr. Deb Muth 00:02What if I told you that before a single drop of chemotherapy goes into a cancer patient’s body, we can take a blood sample, grow their actual living cancer cells in a lab, and test 70 different drugs against those cells, all outside the patient’s body, to find out which ones actually work. And what if I told you that the conventional oncology doesn’t routinely use this test? Well, today we’re going to talk about why that matters and we’re going to go through and I’m going to share a story that is very personal to me. It’s about a 38 year old man with a rare complex cancer diagnosis and the precision testing that is helping to keep that cancer from progressing. Stay with me. This is one that is going to change how you think about cancer treatment. Dr. Deb Muth 01:05You guys can put a little ad right in here before we start the next segment here. Hey everybody, welcome back to Let’s Talk Wellness Now. I’m Dr. Deb and today we’re going deep. I mean really deep. It’s some of the most cutting edge cancer testing I have ever seen in clinical practice. Now, normally I don’t talk about cancer. And I would not be sharing this story if it was anyone other than my own family. I do have permission to share and talk about this publicly. So I want to do this. I want to make sure that I share this message. And he is giving his blessing to share this story because we both believe that it can save lives. So his name is Cameron. He’s 38 years old. And he is my son-in-law. And two years ago, he came to me with a small lymph node underneath his arm and a bullseye rash. So of course, being the lime literate person that I am, my first inclination was to say, yeah, this makes sense. You have an enlarged lymph node because you have this bullseye rash. You got bit by the tick. Let’s keep an eye on it. If it doesn’t go away, let me know. So Fast forward a year and a half later, he comes to me and says, mom, what do you think about this? This thing is getting a little bit larger. And I said, yeah, it’s a little larger. Not sure. Let’s keep an eye on it. He wasn’t feeling anything. All his labs looked okay. And then one day he was out chopping wood and he started getting numbness in that arm and he felt it again. And it had exploded in size. And so after some evaluation with my daughter and him, we decided to do a ultrasound. And we thought what was going to come back was a fatty tumor. It felt like one looks like one responded to one. He’s 38 years old. He’s healthy. There’s nothing in our mind that’s ever thinking the result that we’re going to get back. Dr. Deb Muth 03:28Is a possible lymphoma. Needless to say, we were shocked by that ultrasound result. And we go fast forward, we have the biopsy. I requested a total excisional biopsy. I was told by the oncologist that that was old school. They don’t do that that way anymore. And I need to stay out of this. I need to let the experts take care of this because that’s what they do best. And this came from a breast surgeon here in Wisconsin. And so I stepped back for a moment. I let him do his biopsy and what came back was adenocarcinoma of an unknown origin. Had we excised the entire lymph node, we would have had more tissue to work with. I think we could have gotten a better diagnosis. So over the course of the next two and a half, three months, we have some more imaging done. We have some more testing done. They send a pathology out to Mayo Clinic. And what continues to come back is this incongruent test results. If anybody’s ever had this, it’s extremely frustrating. One test shows lymphoma. Now it shows breast cancer. Then the next week it shows estrogen receptor HER2 positive breast cancer. Two weeks later, another test comes back and it says, no, it’s not HER2, it’s triple negative breast cancer. And now it looks like it’s out of the lymph nodes. Now it looks like it’s in the lymph nodes. And we do a PET scan and they can’t find cancer anywhere except in this axilla area. But now we find a lymph node on the right side. So it must have spread.Let’s go ahead and do a biopsy on that. And so they biopsy the right side and the right side comes back with nothing other than tattoo ink. Now, all of this is kind of crazy. I am not a cancer specialist. I want to start by saying that I am not a cancer specialist. What I am sharing today is from a mother-in-law’s perspective, from a medical detective’s perspective, I do know how to do research. I do know how to find answers. And so what I’m going to share with you Dr. Deb Muth 05:54Is totally my opinion and totally my experience. And I’m not telling anybody to do anything different than what their doctors are telling them to do. But I am telling you to ask questions. So I go deep down the rabbit hole and find out that Tattoo Ink can appear like metastatic cancer on a PET scan. And we all know everybody gets tattoos today. They’re all over everyone. And yet we’re not thinking about how this tattoo ink can cause problems for us down the road, not to mention that there are heavy metals in them and it’s a toxin and it’s creating an inflammatory process in your body that your body’s constantly trying to get rid of. So the surgeon says to us, well, yes, that’s normal that that lymph nodes inflamed. It’s normal that there’s tattoo ink in it. The body’s doing what it’s supposed to do. It’s trying to get rid of a toxin. Okay. I will agree with that, but My son-in-law is covered with tattoos everywhere. And why didn’t we mention the tattoo ink that was found in the left axilla? We are only mentioning it in the right axilla. So there’s a lot of controversy, a lot of confusion. Many of you would never know any of this because A, you either don’t look at your lab results. And if you do, you don’t understand what you’re looking at. And that creates a problem for us, right? You don’t know what questions to ask. So we go into the doctor and the doctor tells us you have cancer and we’re going to swoop you in. And in the next two weeks, you’re going to be doing chemotherapy and radiation. And six months from now, we’re going to be doing surgery and there’s no time for questions and you’re scared shitless and you’re just doing what you can to survive. And I get that. And I totally understand that. And I appreciate that. But I’m telling you that If that is your choice, that is your choice. But as you’re doing that, take the time to ask the right questions. When this happened to us, there was a lot of challenging things with the oncology team. Nobody bothered to allow them to be a partner in their care. They dictated their care, but didn’t allow them to be a partner. So, Dr. Deb Muth 08:17Here’s what most oncologists do when patients get a cancer diagnosis. They look at the tumor type, they look at the stage, they look up the NCC guidelines, the National Comprehensive Cancer Network, and they follow the algorithm. Now, I have an enormous respect for conventional oncology. I really do. Working with cancer is probably one of the hardest things in medicine that anyone can do. The advances in this field over the last 10 years have been remarkable. But here’s my issue. Standard treatment assumes your cancer is the same as the cancer in the clinical trial that created the guidelines. It’s assuming that you and your cancer are the exact same as everyone else. You are the unique fingerprint, not the cancer. And this is the problem because your cancer is unique, just as unique as if you had your fingerprint taken, the mutations driving your tumor, the drugs your cancer cells are sensitive to, the metabolic vulnerabilities of your cancer. These are all different from the person sitting next to you in the chemo suite that has the same triple negative breast cancer or HER2 positive breast cancer or prostate cancer or colon cancer that you have. So what do do about that? Well, in my world, in the integrative medicine world, we test precisely, intelligently with the tools that most oncologists have never heard of. Or if they have, they haven’t incorporated it into their treatment modality for a variety of reasons. Either it’s not acceptable by the organization that they work for, they don’t understand it, They’re not going to be able to change their protocol anyway because they have to follow the NCCN protocol. So they don’t do it or they use a portion of it and they don’t do anything outside the protocol. So today I want to cover three things with you, three tools that we used that I think every cancer patient should be asking for when they start treatment or wherever you are in treatment at this point. Dr. Deb Muth 10:44you need to have these tests done. I don’t have any affiliation with any of these companies. I don’t get paid to tell you any of this. So let me just start by saying that I understand the chemistry behind these and how important it is to give you precision cancer treatment. And that’s why I’m talking about them today. The first one we’re going to talk about is the North Star response. This is your cancer surveillance score in the blood. How much cancer is circulating in the blood. The North Star Select, your cancer’s genomic blueprint from a blood draw. And the Datar Cancer Genetic Chemoscale, the live cell drug sensitivity test that tells us which drugs actually kill your cancer. So let’s go. Let’s dive into this. Let me just take a drink here. I’m going to cough a little bit. I apologize. I have this horrible tickle. It just never seems to go away, but that is not for today to discuss. So what is all of this? OK, the North Star response is a test that was developed by a company called Billion to One. And yes, that name is intentional because of the precision involved. It’s a next generation sequencing test, meaning it reads DNA at an incredibly detailed level. And it looks at something called methylated circulating tumor DNA or methylated CT DNA. Now let me break this down in plain English for you, because this can get a little overwhelming. When the cancer cells die or shed, they release tiny fragments of DNA into your bloodstream. We call this cell-free DNA or CFDNA, and it’s hidden within that cell-free DNA. And there are fragments that come from tumor cells. We call those CT DNA or circulating tumor DNA. Here’s what makes North Star’s response different. Rather than just looking for mutations in that tumor DNA, which is what most liquid biopsies do, and a liquid biopsy is just a blood test, Dr. Deb Muth 13:03This test looks at something called methylation patterns. Think of methylation like a dimmer switch on a gene. In healthy cells, certain genes are switched on and off in a very predictable way. In cancer cells, those dimmer switches go haywire. And cancer DNA has a characteristic hypermethylation, meaning switches are turning on and should be off or off and they should be on. And these patterns are essentially a cancer fingerprint in the blood. Now the North Star response scans more than 2000 locations in the genome for these cancer specific methylation patterns. And then it adds them all up into a single number called the tumor methylation score or TMS. So for Cameron, Cameron’s blood which was drawn on April 20th, 2026, his baseline tumor methylation score came back at 13. Now here’s the critical thing, to understand this was his baseline test, his starting point. And the real power of this test is in serial monitoring, meaning we run it again and again and again over time. And if that number goes up, the cancer activity is likely increasing. If it goes down, we’re likely suppressing the tumor activity. And if it stays flat or falls, that’s telling us that the disease is responding. So this is now in the blood. We have an actual fingerprint and every test from here forward will be compared to this number. Now let’s talk a little bit about this because I was not familiar with this test at all. I wasn’t sure what to expect. I wasn’t sure what to do with it. I did not order this test. He’s working with Inveda Medical and they are fabulous over there. I will tell you that from the beginning. This is coming from a practitioner and from a mother-in-law. They were absolutely wonderful to us. So when I saw this North Star, I didn’t know, should it be zero? Should it be a hundred? And when I talked to the doctor, he said, Dr. Deb Muth 15:29This number is actually really good. An average person walking around who’s never been diagnosed with cancer, who doesn’t have cancer, their number will be between 75 and 100. Cameron’s was 13. I think that’s fantastic. But what was the first question that went through my head? It’s probably the same question that you guys are doing. How can he have cancer with a number of 13 when it’s less than the normal average? And if we’re supposed to use this to track what’s happening with his cancer, how are we going to do that once we remove the cancer? Is this number going to go to zero? And it could possibly do that. And we may not be able to use this to track whether or not the disease is actually gone. But what we can do is use this to track over the course of his lifetime to see if the cancer cells are coming back long before we detect them on imaging. And that’s the huge part of this.So this is not a test that just anybody should go out and get because you’re worried about cancer. It is a test that should be done in somebody that is already diagnosed with cancer. So let’s start by making sure we explain that, okay? So imagine if every time your cancer cells are active and they’re shedding and they’re multiplying and they’re fighting back, they’re leaving a signature in your blood not just any signature, but a specific chemical tag that says, cancer’s here. That’s what the North Star Response Test reads. Those tags across thousands of locations and gives us a single score. So we track that score over time like a thermometer for your tumor. If it goes up, we get concerned. If it stays stable or goes down, we celebrate. And we can catch a change in the blood often months before it will show up on a scan. Pretty important when we’re talking about surveilling somebody for cancer returning, when we’re worried about it, and everybody knows the cancer patient is always worried after they get that clean bill health that something’s gonna come back, and most of the time they’re told that there is no way for them to determine that or know that from a blood test. And here is the blood test that can tell us, yes, it can. Dr. Deb Muth 17:51So I would really encourage you guys to talk to your oncologist about this. If you can’t find an oncologist that will do this, talk to an integrative cancer doctor. They will most likely be familiar with it. If not, ask them to find it for you and order it for you. So next, let’s talk about that genetic blueprint because North Star Select is a different test also by billion to one run on the same blood draw, but this one is doing something completely different. This is a comprehensive genomic liquid biopsy. Liquid biopsy just means blood tusks, meaning it’s looking for specific mutations in 84 cancer related genes, all from a blood sample, no biopsy needle, no surgery, just a blood draw. It looks for CNVS, single nucleotide variants, tiny one-letter typos in the DNA code. It looks for indels, small insertions or deletions in the DNA. It looks for copy number changes, the sections of the genomes that are duplicated or deleted. It looks at fusions. So when two genes incorrectly link together to create a dangerous hybrid, MSI status, micro satellite instability, which tells us whether immunotherapy is likely to work. And it has extraordinary sensitivity. It can detect a mutation that represents as little as 0.15 % of cell free DNA in the bloodstream. That is an almost impossibly small signal in the ocean of genetic noise. So what did this show for Cameron? This is where Cameron’s case gets clinically fascinating and where it tells the story of how his cancer is being held in check. Two major mutations were identified as actionable. One was called CRAS G12C. Dr. Deb Muth 20:11And it’s a variant-ELI fraction at 0.1%. Now, CRAS, if you’ve spent any time in integrative oncology, you’ve heard this name. CRAS is one of the most well-known oncogenes in cancer biology. Think of it like an accelerator pedal in the car. In a healthy cell, CRAS pushes the cell to grow when it receives the signal to do so. And then it stops. In cancer, crass gets stuck in the go position, like on the accelerator, foot on the accelerator, to the floor, going as fast as you can around that track, right? But it’s stuck there permanently. It doesn’t turn off and it’s supposed to be turning off. The G12C variant specifically is a mutation at a very precise location. Position 12 of the CRAS protein, where a glycine is replaced by cysteine. And this matters because CRAS G12C is now a drugable target. There are FDA approved drugs specifically designed to lock this mutation into its inactive state, essentially putting a foot on the brake. Now those are drugs like, and I’m gonna slaughter these names, Sordisib, a brand name is Lumacras, and Atacras, the brand name is Crastol. Neither is yet FDA approved for breast cancer, but they are approved for lung and colorectal cancer with CrasG2C. And Cameron’s tests identified 10 active clinical trials within a region that he could potentially qualify for with this mutation. The fact that his CRAS G12C is circulating at only 0.1%. That is a very low fraction. We call that a VAF, V-A-F, very low fraction. And it tells us something important. It means that this mutation is present in a small subclone of the tumor. It’s not the overall tumor burden. So either way, when we identify, we know it’s there. Dr. Deb Muth 22:37We can catch it and we can watch it. Now, here’s another interesting thing that we saw. His TP53 was at 0.23%. This is a tumor suppressor gene, the guardian of genome. And this gene is responsible for telling damaged cells to either repair themselves or self-destruct. And when it mutates as it is here in the position R196Q, that guardian goes off duty. The cell no longer has a reliable mechanism to prevent uncontrolled growth. So TP53 mutations are present in roughly 50 % of all human cancers. And there’s currently no FDA approved drug directly targeting the TP53 but there are clinical implications. TP53 mutant tumors may respond differently to chemotherapy and several investigational approaches, including TP53 vaccines and aurora kinase inhibitors are under active investigation. So we are seeing things happen in this part of cancer right now. Now there’s something called the VUS list and we are watching This is what we’re watching. beyond those two actionable mutations, NORSTAR Select identified what we call variants of an unknown significance, VUS, adenocarcinoma of an unknown significance, ACUP. These are mutations where we don’t yet have enough clinical evidence to determine whether they’re driving cancer or not, but we watch them. So on our mutation list was CDH1, a gene linked to hereditary gastric and lobular breast cancer, CDKN2A, a tumor suppressor cell cycle regulator, CDK12, involved in DNA repair, EGFR, ERBB, this is HER2 receptor, tyrosine kinases. Dr. Deb Muth 24:55I thought this one was pretty interesting since he had an IHC that showed a three plus HER2, but then when we confirmed it with FISH, FISH showed that was negative, but now we’re actually seeing genes expressing this HER2. So is there a HER2? Is there not a HER2? This is really important because if we don’t get these diagnoses right in cancer the first time, people will spend months and years treating the wrong type of cancer with the wrong type of medication. And this may be in part why some people do better than others. If we get it right out of the gate, they do good. If we don’t get it right out of the gate, they don’t do so good. Very important to have the actual genetic makeup of the tumor that’s growing in somebody. Now last, we have something called Notch C1, NRAS and RAF1. These are key pathway components. Now all of these were at very low baffs under 0.5%. These are just whispers, not shouts, but whispers that this cancer is excreting, but your body is listening. We have to be listening. We have to be able to watch these things and monitor these. Now here’s another note of clinical interest. It was an androgen receptor positive cancer. So also detected as a VUS.We know from tissue pathology that Cameron’s tumor was androgen receptor positive. So seeing this in circulation confirms that this AR expression of the cells are present in the bloodstream and that an anti-androgen approach remains worth considering. What that means is suppressing the testosterone. What all of you know I’m about ready to say is that I hate ever suppressing hormones, especially in a 38 year old male. That is not necessarily a good thing. So before we go suppressing hormones willy-nilly, we have to know that it’s the right thing to do. And we have to be able to combat all of the complications that are going to result of that. A 38-year-old male with no testosterone could lead to heart disease down the road, could lead to bone loss, could lead to dementia, Alzheimer’s. Not to mention the sexual side effects that are going to be present. And in a man that is very, very Dr. Deb Muth 27:20Difficult for someone to manage. So you have to be very specific and you want to be very, very diligent about what you’re doing in these cases like this. Now the MSI status was not detected. This tells us that cancer is not a microsatellite instability high, meaning that standard monotherapy may have a lower baseline response of probability and the strategic integration that we’re working with with in Vita could create an immunogenesis genicity becomes even more critical. So immunotherapy is going to be very critical in a cancer case like this and working with somebody that understands that and can carefully navigate that, especially if you have an autoimmune disease like Hashimoto’s or lupus, this is all very, very pristine and has to be looked at very carefully and done very diligently in order for somebody to do this without overstimulating that immune system and causing more problems. So when we looked at the blood and found this DNA fingerprint of the cancer cells circulating in the body, from that, what we see exactly is the genetic switches that are stuck on. They’re stuck on in the wrong position. This tells us which drugs were designed to fix exactly that problem. And it opens the door to clinical trials built for these specific mutations. It also gives us a list of things to watch for over time. And if one of those tiny little signals starts to grow, we know that cancer is gaining a ground in that area. And if it shrinks or disappears, we know we’re winning. This is like, I cannot tell you how exciting this is in the cancer world and the medical world because this is really pristine cancer therapy that we’re dealing with here. And to be able to have this is just so important to life saving events in treating cancer. So. Dr. Deb Muth 29:41Let’s talk about something called the Dittar Chemoscale. This is the battle before the battle. Okay, so I’ve saved the most remarkable test for last, and this is one from a company called Dittar Cancer Genetics. They’re based out of the UK. They are CAP and CLIA certified, which means it meets the rigorous standards required for clinical laboratory testing in the US. And this test is called the ChemoScale. And it is a live cell chemosensitivity assay. So let me explain exactly what that means because it sounds complex, but the concept is actually quite elegant. When we drew the blood from Cameron, the Dittar’s laboratory isolated what are called circulating tumor associated cells or CTACs. And these are actually living cancer cells and they’re associated cells that are traveling through his bloodstream. Excuse me. So let’s think about that for a moment. Real live cancer cells isolated from a blood draw. Those living cancer cells were placed into a lab environment and exposed to over 70 different drugs, both conventional chemotherapy agents and what we call repurposed drugs. I’ll talk more about those in a minute. The lab then measured how many of those cancer cells were killed by each drug expressed as a percentage of cell death. So the scale runs from zero to a hundred and below 25%, that drug doesn’t work well against any type of cancer in that person. Might work great in somebody else, but in that particular person’s cancer that they have, it’s not gonna work so great. Anything that’s 25 to 50 % is intermediate and above 50 % is a high response. And that’s really where Dr. Deb Muth 31:43we want to be. We want to see anything higher than 50 % because that’s a great medication that can be used to kill the cancer. This is not a theoretical test. This is not based on tumor’s genetic sequence and the computer algorithm that predicts the drug response. This is a HIS actual tumor cell being killed or not being killed in real time. That is the difference. So in traditional chemotherapy, we have our protocols. If you have triple negative breast cancer, if you have HER2 positive breast cancer, if you have prostate cancer, if you have colon cancer, here’s the protocol that you’re going to use because that’s the type of cancer you have. That’s what’s been studied. Now, the problem is most of these cancers have mutated over time, especially depending on how long they’ve been in your body, because that’s what they do to try to survive. They have to change so they can survive because your immune system’s constantly trying to kill them. And so this is a really important thing. And if we don’t take an individual into response or into our thought process when we’re creating these protocols, we may give a drug that doesn’t work at all towards that cancer and you just wasted seven cycles of chemotherapy with a drug that never would have worked in the first place or had such low resistance to it that it’s now just created side effects for you but did nothing to the cancer. And then we pull out another drug and we try that. And then we pull out another drug and we try that. Instead of us knowing precisely what we can use and what we can do. And this goes for both the conventional world and the alternative world. In the alternative world of cancer, we use things like IV vitamin C and tumeric and lately ivermectin and fenbendazole and mendendazole and all kinds of other things. And if we are not truly aware that this is going to do anything, we could be wasting somebody’s time and money. So I love that this test is available. I want to walk you through a little bit about what Dr. Deb Muth 34:01we are what we saw in our case, because I think this can make a big impact on people to ask the right questions. So this particular blood test looked at several different drugs. Cameron had sensitivity from 44 % up to 61 % on different medications. Now he was really lucky. The three main drugs that they would use to treat his cancer he had greater than a 50 % response to. So that was great. However, the drugs that were recommended for him to use out of the gate had less than 50 % activity. So he would have had one drug that was really good, one drug that was not so good. And we don’t know what the outcome would have been, right? So I think this is such an incredible, incredible test to have done. This is critical friends. I’m telling you if his oncologist had chosen the two drugs based on the general guidelines for his tumor, his cells would have largely not survived. But because we ran this test, we know. So we know to avoid the drugs that won’t work and we focus on the firepower where it really counts. So I want to also talk about this repurposed drug result because this is where it gets integrated for us. Now, this section is what I want everyone in our community, our Let’s Talk Wellness community, our members to understand. This is where conventional medicine and integrative medicine intersect in a peer-reviewed clinical validated way. So the Dittar test looks at live cancer cells against what they call repurposed drugs, meaning pharmaceuticals and natural compounds that were developed for the purposes, for other purposes, like it could be an antibiotic, it could be an herbal medicine, it could be all kinds of things, vitamins, whatever. But they have demonstrated anti-cancer activity in research. And when we’re talking about integrative medicine, this is a lot of where we get Dr. Deb Muth 36:26The integrative protocols from because these particular drug compounds are known for having anti-cancer benefits. And so that’s how integrative protocols get developed. But again, it could be just like medication, like cancer drugs. If your body doesn’t have a susceptibility to it, then you’re using a product that’s not necessarily going to work. And we all know we cannot take everything that somebody recommends just simply because it has an anti-benefit to whatever it is we’re treating. There’s only so many supplements you can take. There’s only so many things you can do before you get burnt out on taking it. We call it supplement fatigue. And so we want to be very precise with what we’re doing and target this very specific area. So one of the things that showed up really, really well for our case was artemisium, sweet wormwood. It’s an anti-malarial drug that has very potent anti-cancer effects. Now I found this extremely interesting in Cameron’s case because he does have a positive tick-borne illness called Babesia. And this is one of the things that we use to treat Babesia. The other thing I think is very interesting in this case is we are studying how parasites affect cancer these days. And that’s how Ivermectin, Fenbendazole, and Menbendazole have all gotten thrown into the treatment of cancer. And so for this drug or this herb to be sensitive to this type of cancer is really intriguing to me in the world of parasites and how parasites are truly decreasing the body’s immune system and causing cancer to grow. Another thing that worked, showed up really well for him was Valprolac acid. It’s an anti-seizure drug with HDAC inhibitor properties, and this disrupts cancer cell gene expression. There was a soy formula that showed up really well. Naltrexone, you guys have heard me talk about low dose naltrexone, LDN. This actually stimulates an endogenous opioid immune response feeling, and this drug actually showed up really well. Dr. Deb Muth 38:49Something as simple as quercetin. It’s an anti-inflammatory. This is a crass inhibitor in some studies. So this is really important. I’m sure most of you have heard about the benefits of green tea and green tea also actually has anti-angiogenic or anti-cancer benefits to it. Hydroxychloroquine, very popular drug. It’s another anti-malarial drug. So again, now we have two anti-malarial drugs that are susceptible to this type of cancer. And on top of it, he has a positive babesia test. So just saying, you got to connect the dots sometimes. You got to think outside the box sometimes. Metformin is very well known as a anti-proliferative in cancer. We use it to suppress the sugar because sugar feeds cancer. Nobody should be eating sugar if they have cancer. So this one showed up as well. And then CBD, we all know of the benefits of THC, the Rick Simpson oil, and CBD can be tested to see if that is beneficial to a particular cancer cell. This is different than THC. THC works very differently in cancer. CBD is your healthy component of it. It’s the part of the marijuana plant that does not make you high. So very important here. So now let me be very clear, because I always try to be very clear. This is not FDA approved. I’m going to repeat that. This is not FDA approved. This test is a laboratory developed test, not FDA cleared. These results represent in vitro testing, meaning in a lab, not inside the human body. And the results can differ in what we call in vivo, inside the body. And this is why I always say work with a qualified clinician who can interpret these results in full clinical context. But here’s why this matters. We now have evidence, live evidence of a cancer cell that shows sensitivities to compounds that are accessible, relatively safe, and some of which he may already be using, which some of them we were. Dr. Deb Muth 41:13We were already using some of them, which made us sit back and say, this cancer has been in there for two years. If it’s a triple negative breast cancer, it’s supposed to be an aggressive breast cancer that should have spread to a different organ already after two years. It is not, it has stayed in one spot. Also interesting in this case is that there is no breast tumor that they could find anywhere. This was all confined to the axilla into the lymph node. So to have this growing for this period of time with such a small tumor marker number, that 13 that we talked about in the North Star test originally, and to see some mutations, there’s a lot of questions to this particular case. And there are lots of questions to everybody’s cancer case. They are not all straightforward cancer cases. So this is what’s important to understand this fingerprint of these cancer cells so that you can identify exactly, exactly what’s going on and treat it exactly the correct way. Super important. So this kind of information gives us the direction in an integrative protocol. It’s not guessing. This is not eat more tumor, I can hope for the best. This is personalized tumor specific precision guided integrative oncology. It is very precise. There are several countries, several clinics like this around the country that offer this type of therapy. If it’s something that you’re interested in doing, I would encourage you to look at in Vita Medical. Hope for Cancer is another great facility. There are several great facilities around the country. Like I said, that could put together an integrative approach for you if this is something that you are thinking about doing. If you’re looking for answers, if you’re in stage four or stage three and you are not getting the results that you want to get, you want to look at a different approach. You want to do a combo approach of integrative medicine and traditional medicine and alternative medicine. Dr. Deb Muth 43:37I think this is so important to look at and have experts on your team. You know, in our case, Cameron’s cancer is very complex. It’s genomically aggressive in its presentation, yet it’s not progressing to distant areas, which is so wonderful. And I want to be careful here. I can’t tell you with certainty that this is any one thing. Biology is complex. Cancer is adaptive. It’s trying to survive. That’s what it is supposed to do. It is changing its shape. It’s changing its genetic structure. It’s changing everything to try to survive and try to hide against your immune system. Now we are not even close to the finish line in our journey, but what I can tell you is that what the integrative precision approach has done that standard care alone might not do. I can tell you that today and I will share our journey along the way for any of you that are going through this that want to look at a different approach as well because I think it’s important to have this information. So first of all, we know the tumor’s fingerprint. North Star response gives us that TMS score. so we can track it over time. And if the cancer tries to gain ground, we’ll see it in the blood before a scan, we’ll show it. We know the cancer’s genetic vulnerability. We know how to handle the DNA now. We know the watch list of things to look for. And when those signals start to grow, we have a roadmap of how to address it next, how to change it. We know which drugs will automatically work against the tumor cells. We’re not guessing based on a tumor type. We tested the cells. We know how many drugs in the commercial world and in the repurposed world will and will not work. And this is going to guide the treatment protocol that we walk forward with. So we’re not giving him drugs that won’t work or have a low response. Dr. Deb Muth 45:55We’re avoiding them completely and that matters because every ineffective drug is a dose of toxicity with no benefit. There is no lie to this. Chemotherapeutic drugs are toxic. That’s how they kill the cells, but they kill the good cells and the bad cells. And if we can avoid using a drug that’s not going to work, that is so important. And then we’re layering in those repurposed and natural compounds with proven activity against specific cells. This is not complementary fluff. This is biologically active tumor tested precision medicine. Very, very important. So here is what I need you all to know and what I want you to walk away with today. If you or someone you love is facing a cancer diagnosis before treatment starts, before the first infusion goes in, I want you to ask these questions so quick. Go grab something to write with. Pause this if you need to, because this is really, really important for you to do that. And we’re going to take a break for just a second while you guys go and do that. We’re going to give you a word from our sponsor, and then we’re going to come back. And I’m going to give you the four questions that I want you to ask specifically of your medical team so that you have the answers and the ammunition that you need to work with. So we’ll be right back. Dr. Deb Muth 47:29All right, everybody, welcome back. I hope you got your pencil, your paper, your pen, your phone, whatever you’re going to take notes with because this is important. So I’m to give you four questions that I want you to ask your medical team before you get started. Question one, can we do a chemo sensitivity test before we choose a chemotherapy regime? Ask specifically about DATAR, D-A-T-A-R. cancer genetics, Oncostat Plus, or a similar functional chemosensitivity platform. Very, very important to ask those specific things. All right, question two. Can we do a comprehensive liquid biopsy to identify actionable mutations and monitor tumor burden? Ask about North Star Select, Billion to One, Guardian 360, or Foundation One Liquid CDX? I’m gonna say those for you one more time, because I said them kind of fast. North Star Select by Billion to One, Guardian 360 or Foundation One Liquid CDX? Okay, question three. Can we establish a baseline tumor methylation score, TMS, so we have a surveillance marker to track over time? and ask specifically about the North Star Response Test. All right, question four. Is there an integrative oncology center that can layer precision guided natural compounds alongside conventional treatment? Research institutes like Inveda Medical Center, CTA CA Integrative Medicine, or Hope for Cancer, these people are doing integrative medical miracles. Let me tell you, I have researched every one of them. I have spoken to each of them individually before we made our decision of who we were going to work with. They are all fantastic. You want to work with an integrative nurse practitioner who understands oncology. And if you’re working with an integrative practitioner, you want to ask them these same questions about this test so that you can get the best outcome. Dr. Deb Muth 49:56For what you’re dealing with. You are allowed to ask these questions. You are allowed to want more information from that protocol that was designed for the average patient. You’re not average and your cancer is not average either. And your care doesn’t have to be. You do not have to settle for the same thing that the person sitting next to you in the IV suite is dealing with when you both have different cancers excreting different genetic material. This is so incredibly important. want to make sure you understand precision medicine is what changes the lives for people every single day, every single day. So I started this episode by telling you about a 38 year old man with a cancer that baffled conventional medicine and integrative medicine, an occult primary that was not found complex genetic genomic profile, a presentation that in many hands might have resulted in a one size fits all treatment protocol and a prayer. And instead we ran the tests, we mapped the fingerprint, we watched the cells, we guided the protocol, and we are still fighting with precision, with data, with intelligence. This is what Let’s Talk Wellness is all about not giving up. This is what not accepting we don’t know as a final answer and demanding the level of scrutiny and personalization that every cancer patient deserves. So if this episode resonates with you, please share it because somewhere out there, there is a person who is about to get the wrong chemotherapy because no one ran the right test. And maybe, just maybe, that This episode will be the reason someone asks the right question at the right moment. If you’re going through something like this, you need a group, you need somebody to connect with, please join our free Facebook group called Seen At Last. It is where we support one another, we share this information, we share knowledge, and we help people for free support and ask the right questions. Dr. Deb Muth 52:23And if you’re inclined in your heart to pray, pray for Cameron, we could use every ounce of prayer. If you are in a position where you can help support this journey financially, we do have a fund going in free funder. I can post the link below. Every little bit helps. If you have $5, $500, it doesn’t matter. We’re raising money for this treatment. And along the way, I am documenting every step of what we’re going through so I can provide more episodes like this for you guys to share the outcome and share what our journey is like so that it can help the next person along. I really always believe that whatever happens to us happens to us because we’re meant to share it. That’s why I’ve shared my personal journey. I’m sharing his personal journey and we want to help other people. So until next time, I’m Dr. Deb. Keep asking questions, keep advocating, and never ever accept being unseen.The post Episode 274 – Stop Guessing on Chemotherapy: The Live Cell Test Most Doctors Miss first appeared on Let's Talk Wellness Now.

SPONSORS: 1) MARS MEN: For a limited time, our listeners get 50% off FOR LIFE, Free Shipping, AND 3 Free Gifts at Mars Men at https://Mengotomars.com JOIN PATREON FOR EARLY UNCENSORED EPISODE RELEASES: https://www.patreon.com/JulianDorey CLIPPERS DISCORD: https://discord.gg/8QmWEKJ3BT (***TIMESTAMPS in description below) ~ Ben Westhoff is an investigative journalist and one of the most respected experts on the fentanyl crisis in America. His 2019 book, Fentanyl, Inc. exposed the entire fentanyl market problem to the mainstream FOLLOW BEN: IG: https://www.instagram.com/ben.westhoff/?hl=en BOOK: https://a.co/d/03cARvfi DOC: https://www.antagonistfilm.com/ FOLLOW JULIAN DOREY YT: https://www.instagram.com/julianddorey/ X: https://x.com/juliandorey JULIAN YT CHANNELS - SUBSCRIBE to Julian Dorey Clips YT: https://www.youtube.com/@juliandoreyclips - SUBSCRIBE to Julian Dorey Daily YT: https://www.youtube.com/@JulianDoreyDaily - SUBSCRIBE to Best of JDP: https://www.youtube.com/@bestofJDP ****TIMESTAMPS**** 00:00 - Fentanyl Inc., Rave Deaths, China Labs 08:50 - Undercover in China, Suspicious Lab Visit, CCP Rebates 22:51 - Capitol Hill Testimony, Fentanyl Analogs, India Precursors 29:55 - Naltrexone, Vivitrol, Addiction Treatment, Methadone Business 39:49 - Psychedelics, Capitalism, Naltrexone Documentary, Dark Web Dealers 49:29 - Fent-Laced Coke, Antagonist, Percy Menzies, Vivitrol Trials 58:18 - AA, Opioids, Alcohol, Compulsive Behaviors, Naltrexone Critics 01:10:32 - Addictive Personalities, Purdue Pharma, Suboxone Pill Mills 01:11:10 - Standard American Diet, Veganism, Factory Farming, New Holocaust 01:23:43 - Factory Farming, Forks Over Knives, Subsidies, Protein Obsession 01:39:29 - McDonald's Subsidies, Vegan Costs, Grocery Prices, Sports Gambling 01:48:14 - Silk Road, Bitcoin, Gold, Dark Web Dealers 01:58:45 - Online Drug Markets, Snowden, FISA, Hip Hop Journalism 02:08:08 - Eazy-E, Cancel Culture, Substack, NuWaubians, MF DOOM 02:21:05 - Afrika Bambaataa, Music Journalism, Kanye, Narratives 02:29:01 - Streaming, West Coast Hip Hop, Jimmy Iovine, Tupac 02:40:53 - Interscope Records Scandals CREDITS: - Host, Editor & Producer: Julian Dorey - COO, Producer & Editor: Alessi Allaman - https://www.youtube.com/@UCyLKzv5fKxGmVQg3cMJJzyQ - In-Studio Producer: Joey Deef - https://www.instagram.com/joeydeef/ Julian Dorey Podcast Episode 434 - Ben Westhoff Learn more about your ad choices. Visit podcastchoices.com/adchoices

Check Out BioVitalis Peptides: https://biovitalis.org/ (Use Promo Code: GSD10 for 10% off)   Check Out Jim Brown's Substack Blog: https://substack.com/@forj   *Disclaimer: This NOT medical advice. Please make sure to seek your own medical professional for medical advice.   On this Podcast we break down our personal "Forever Peptides" vs the Peptides we cycle and/or the peptides we use at specific times of the year or as needed. We also dive into questions we received over the past week on peptides, nutrition, TRT, etc... If you have any questions, please send me an email Joshua@GSDMode.com and here are the questions we jump into this week:   -Question: When are you guys going to do a gear podcast? (I asked if He had any specific questions on "Gear") yeah I'd say a good first cycle , thoughts on tren ?, is it worth it low dose maybe ? Mast .   -Question: question: Your thoughts on using Trenbolone Enanthate at 150mg/week, instead of using Testosterone Cypionate 150mg/week for TRT?    Question: Hey guys! Once again thanks for all the great info! I just had my shoulder surgery yesterday and started my aggressive healing protocol this morning. I am in an adductor sling for the next 6 weeks. I start PT in a week, but I can take my arm out to breath and clean in 72 hrs. Can I pin my lats or tricep? I want to administer the bpc as close as possible but atm I can't seem to do it one handed and in my current state. I have been sticking to my stomach but I know the closer the better.   Question: Really appreciate all the great practical information. Could I please have your opinion on the compound Tesofensine. Any info will greatly appreciated. Thank you   Question: Hi Josh, Hi Jim. Amazing work all the time Gentlemen! Have you heard of / researched taking LDN (low-dose Naltrexone) for inflammation reduction? And, have you heard of / researched FLGR-242, a modified version of Follistatin-344, which has been available to the public since approximately November of 2025.   Question: I've been taking 200 mcg of cjc 1295 and 200 mcg of ipamorelin before bed 5 days on and 2 days off for about a month. I was not sleeping well on the nights i took it. 2 days ago I started taking1mg of tesamorelin and 200mcg of ipa before bed and cjc and ipa in the morning. I woke up with a headache both mornings. I was take half the amount of tesa and see what happens. Just curious what you thought was causing the headache. Thanks for all the good info guys!   Question: I've been on Reta for 4 months and have lost 15 pounds and 2 belt sizes, but my blood pressure is up and was a little high when I started it. If I stop Reta what should I take instead? I am going to start Tesa and wolverine stack for injury and to address gut problems. Still need to lose 30 pounds from waist up! 57 years old. Thanks!   Question: Hi guys! You talked about SS-31 and MOTS-C and running one before the other. I'm currently running SS-31 and planning to add in MOTS-C after a few weeks. I'm hearing that adding in NAD+ on opposite days of MOTS-C is beneficial. Have either of you done this? And if so, would you suggest that I add in the MOTS-C first and then a couple of weeks later, the NAD+? What are your thoughts? Thanks so much!   Question: Is there anywhere to look at the Reta statin data for plaque? My buddy had a widowmaker at 46 last month; it has me worried about my heart health at 54. I have a mild blockage in my LAD. I am on Tirz and a statin as is. If there is a way to reduce it at all I would be willing. Thanks!! Love the show!

In this episode of Beyond The Abstract, Dr. Manish Jha stops by to talk about his new article Craving, Impulsivity, and Subsequent Methamphetamine Use With Naltrexone-Bupropion Versus Placebo: Findings From a Randomized Clinical Trial featured in the March/April issue of the Journal of Addiction Medicine.   Article Link: Craving, Impulsivity, and Subsequent Methamphetamine Use With Naltrexone-Bupropion Versus Placebo: Findings From a Randomized Clinical Trial

Welcome Back! Today we are discussing the medication Naltrexone and its uses in psychiatry. References: https://www.ncbi.nlm.nih.gov/books/NBK534811/https://pubmed.ncbi.nlm.nih.gov/24825644/https://pubmed.ncbi.nlm.nih.gov/26798982/https://www.nejm.org/doi/full/10.1056/NEJMct0801733https://pubmed.ncbi.nlm.nih.gov/26798982/

This week Vic is joined by journalist and podcaster Katie Herzog to talk about the winding, messy road many of us take trying to figure out our relationship with alcohol.Katie shares what her drinking looked like during Covid, how it quietly ramped up behind closed doors, and the strange mental gymnastics of hiding drinking from partners and pretending your fine and dandy, when really... it's all falling apart.They talk about the moment when drinking stops feeling fun and starts feeling lonely, the awkward reality of not quite connecting with AA, and the long search for something — anything — that might actually help.Eventually that search led Katie to Naltrexone, a medication used to reduce the brain's reward response to alcohol. For Katie, discovering it changed everything. Over time it helped rewire the habit loop, take away the obsessive pull toward drinking, and slowly create something she hadn't felt in a long time… freedom from alcohol.The experience was so transformative that Katie went on to write a book about it, exploring the science, the stigma, and why conversations about medication and sobriety can be so surprisingly controversial.It's an honest chat about finding your own path, challenging recovery dogma, and the strange relief of realising there might be more than one way to get sober.Find out more about Katie and buy her book here -drinkyourwaysober.comhttps://www.amazon.com/dp/163774739Xhttps://www.simonandschuster.com/books/Drink-Your-Way-Sober/Katie-Herzog/9781637747391follow her on twitter here - @kittypurrzog

In this episode ,Will, Paul and John discuss medications for Alcohol use disorder (AUD) . In this episode, we unpack the evidence-based pharmacotherapies that support recovery, including Naltrexone, Acamprosate, and Disulfiram and more. This is a practical, stigma-aware conversation focused on improving outcomes—because effective treatment for alcohol use disorder should be accessible and evidence-based.Don't forget to leave a rating so others can find us and send any questions to LiverHealthPOD@gmail.com

Naltrexone is an FDA-approved drug that helps people beat addiction by blocking the effects of opioids and alcohol. Yet it's not as widely known, or used, as the emergency overdose reversal drug naloxone, known by the brand name Narcan. St. Louis journalist Ben Westhoff's new documentary “Antagonist” explores why. Westhoff and Assisted Recovery Centers of America President Percy Menzies join us to discuss why naltrexone is so effective at treating opioid and alcohol misuse and how the drug got sidelined by big money interests.

André, The Impulsive Thinker™, sits down with Amber Harper to share her moving journey at the intersection of ADHD and addiction. Amber—a seasoned data analyst, writer, and co-founder of ADHDandAddiction.com—gets real about how her ADHD diagnosis shifted her recovery process and offered new hope. They discuss denial, anger, relapse, and why recovery looks different for ADHD Entrepreneurs. If you've ever used alcohol or food to cope, Amber's honest perspective and tips on community support will hit home. Listen to learn how understanding your ADHD can change your relationship with addiction and open the door to true personal growth.  

Holiday Stress tops tax season stressWhat would Dr. Hoffman say?Is berberine truly efficacious?My doctor recommends I drink alcohol to reduce stress and improve circulation

What do you think of thiamine as a treatment for Parkinson's?Is there a natural thyroid medicine you recommend that is not pork-derived?Please discuss the COVID-19 vaccine and cardiology issuesCan you help my granddaughter with guttate psoriasis?

Katie Herzog spent 15 years trying everything: AA, therapy, CBT, SMART Recovery, moderation management, swapping booze for weed. Nothing stuck. And in the back of her mind, she always knew she'd start drinking again. It was just a question of when. Then she found the Sinclair Method—a protocol where you take a medication called naltrexone, wait an hour, and drink. It sounds too simple. It sounds like cheating. But is it? Katie's been completely sober for three years. In this conversation, we dig into the science of how naltrexone rewires your brain, why the first three months don't look like much, and why realistic expectations might be the most important factor in whether this works for you. In this episode, we cover: → Katie's 15-year journey through AA, therapy, misdiagnosis, and desperation—and why the idea that abstinence is the only path kept her stuck for years → What the Sinclair Method actually is and how naltrexone blocks the endorphin rush that makes drinking feel good → The difference between "reward drinkers" and "relief drinkers"—and who TSM is best suited for → Why Katie's first attempt with naltrexone failed (and what she did differently the second time) → AND MUCH MUCH MORE. This episode is for you if: You've tried AA or other programs and they didn't stick The idea of "never drinking again" feels impossible You're curious about medication-assisted approaches but don't know where to start You're exhausted by the mental chatter—always thinking about drinking whether you're drinking or not You want to understand ALL the options, not just the abstinence-only path About the book: Drink Your Way Sober: A Science-Based Method to Break Free from Alcohol releases September 30th and is available on Amazon and at independent bookstores. Connect with Katie Herzog: Website: drinkyourwaysober.com Podcast: Blocked and Reported If you are ready to get support from a community of women who are co-creating this change with intention and clarity— Click here to BOOK A DISCOVERY CALL.  Find me on: YouTube: @HangoverWhisperer TikTok: @hangoverwhisperer Instagram: @thehangoverwhisperer  X (Twitter) : @NotAboutTheAlc   Transcript  

Ep. 701: Mr. Harrison's Confessions | Chapters 15-19 Book talk begins at 12:20 Let's just say: gossip is blooming faster than the primroses. --------------------------------------------------------------- 1:46 - Naltrexone 3:01 - Don't forget to send us your crafty videos 03:23 - BOOKMARKS sign up through November 21st, send by December 6 for International and 13th for in-country — link: https://bit.ly/bookmark-exchange 4:04 - Philly fabric stores video (send info on your local/indie fabric stores for us to share!): 05:50 - I saw Guillermo del Toro's FRANKENSTEIN 7:00 - Frankenstein's Gay Maker: James Whale, The Queen of Hollywood 12:20 - BOOKTALK 15:48 - Fire Screens BOOK/WATCH PARTIES coming up in 2025: 46:48 - all parties are at 8pm Eastern: Nov 20th— Random Harvest (movie) Dec 18th — Lamb: The Gospel According to Biff, Christ's Childhood Pal by Christopher Moore (book) *CraftLit's Socials* • Find everything here: https://www.linktr.ee/craftlitchannel • Join the newsletter: http://eepurl.com/2raf9 • Podcast site: http://craftlit.com • Facebook: https://www.facebook.com/CraftLit/ • Facebook group: https://www.facebook.com/groups/craftlit • Pinterest: https://www.pinterest.com/craftlit/ • TikTok podcast: https://www.tiktok.com/@craftlit • Email: heather@craftlit.com • Previous CraftLit Classics can be found here: https://bit.ly/craftlit-library-2023 *SUPPORT THE SHOW!* • CraftLit App Premium feed bit.ly/libsynpremiumcraftlit (only one tier available) • PATREON: https://patreon.com/craftlit (all tiers, below) ——Walter Harright - $5/mo for the same audio as on App ——Jane Eyre - $10/mo for even-month Book Parties ——Mina Harker - $15/mo for odd-month Watch Parties *All tiers and benefits are also available as* —*YouTube Channel Memberships* —*Ko-Fi* https://ko-fi.com/craftlit —*NEW* at CraftLit.com — Premium Memberships https://craftlit.com/membership-levels/ *IF you want to join a particular Book or Watch Patry but you don't want to join any of the above membership options*, please use PayPal.me/craftlit or CraftLit @ Venmo and include what you want to attend in the message field. Please give us at least 24 hours to get your message and add you to the attendee list. • Download the FREE CraftLit App for iOS or Android (you can call or email feedback straight from within the app) • Call 1-206-350-1642

This week, Molly welcomes back Ian Andersen, co-founder of Sunnyside, for a timely and thought-provoking conversation on the evolving landscape of alcohol health and behavior change. Ian shares the backstory of Sunnyside's growth from its origins during the pandemic to the recent launch of Sunnyside Med, a new initiative designed to support individuals seeking more structure and support in reducing their alcohol consumption.If you're feeling challenged during “More Sober October,” or you've ever felt like you're behind the curve while the media insists everyone is drinking less, this episode offers reassurance, insight, and practical next steps.What You'll Learn:Why Sunnyside was founded and how its inclusive, non-prescriptive model fills a critical gap in alcohol supportWhat Sunnyside Med is and who it's designed to helpThe disconnect between public alcohol trends and personal strugglesHow the cultural narrative around moderation is evolvingWhy sustainable change requires systems, not shameThe psychological barriers that often prevent progress and how to overcome themQuotable Moments“We don't want to be the food scale or calorie counter of alcohol. We want to be a guide, not a judge.” – Ian Andersen“Just because the news says people are drinking less, doesn't mean you feel less stuck.” – Molly WattsResources and LinksLearn more about Sunnyside: www.sunnyside.coGet details on Sunnyside Med: https://www.joinsunnysidemed.com/Visit Molly's site for courses and coaching: www.mollywatts.comLow risk drinking guidelines from the NIAAA:Healthy men under 65:No more than 4 drinks in one day and no more than 14 drinks per week.Healthy women (all ages) and healthy men 65 and older:No more than 3 drinks in one day and no more than 7 drinks per week.One drink is defined as 12 ounces of beer, 5 ounces of wine, or 1.5 ounces of 80-proof liquor. So remember that a mixed drink or full glass of wine are probably more than one drink.Abstinence from alcoholAbstinence from alcohol is the best choice for people who take medication(s) that interact with alcohol, have health conditions that could be exacerbated by alcohol (e.g. liver disease), are pregnant or may become pregnant or have had a problem with alcohol or another substance in the past.Benefits of “low-risk” drinkingFollowing these guidelines reduces the risk of health problems such as cancer, liver disease, reduced immunity, ulcers, sleep problems, complications of existing conditions, and more. It also reduces the risk of depression, social problems, and difficulties at school or work. ★ Support this podcast ★

Addiction doesn't always look like rock bottom—and recovery doesn't have to mean all or nothing. In this episode, Lyndsay Soprano sits down with Katie Lain for a powerful conversation about alcohol, family patterns, and the complicated truth about what healing from addiction can actually look like.They dive into the neuroscience of alcohol use and the way it hijacks the brain's reward system, challenging the outdated narrative that addiction is simply a lack of willpower. Katie shares her personal experience and introduces the Sinclair Method, a treatment approach that uses naltrexone to gradually reduce alcohol cravings—without requiring total abstinence from day one.Lyndsay and Katie also talk about the emotional layers of drinking: early exposure, social pressure, generational trauma, and the quiet shame that keeps so many people stuck. This episode is about choice, compassion, and giving yourself permission to explore recovery in a way that feels honest and sustainable.Tune in if you've ever questioned your relationship with alcohol—or if you're ready to let go of the idea that healing only counts if it looks a certain way.Find Katie Lain Online Here:Website: thrivealcoholrecovery.comInstagram: @thrivealcoholrecoveryFacebook: Thrive Alcohol RecoveryLinkedIn: Katie LainYouTube: Thrive Alcohol RecoveryPodcast: Thrive Alcohol RecoveryFind The Pain Game Podcast Online Here:Website: thepaingamepodcast.comInstagram: @thepaingamepodcastFacebook: The Pain Game PodcastLinkedIn: Lyndsay SopranoYouTube: The Pain Game PodcastEpisode Highlights:(00:00) Introduction to Chronic Pain and Alcoholism(02:06) Personal Stories of Alcohol and Family Influence(06:12) Understanding Alcohol Addiction and the Brain(10:16) The Sinclair Method Explained(15:17) The Journey to Recovery and Finding Freedom(20:08) The Challenges of Alcohol Consumption and Social Norms(24:42) Advocacy and Awareness for the Sinclair Method(28:39) Low Dose Naltrexone and Pain Management

THROWBACK: Katie Herzog*****This is a THROWBACK episode with guest Katie Herzog.*****Katie first appeared on the show on December 23, 2024.The book she was writing at that time, and that we talked about, IS NOW AVAILABLE!'Drink Your Way Sober' is available everywhere, and we are giving 4 copies away in this episode!Take a walk with me down Fascination Street as I get to know Katie Herzog. Katie is a well-known and respected journalist who has written for publications including: The Stranger, The Atlantic, Reason, Medium, and more. She is also a co-host of the very popular podcast Blocked and Reported; with her friend and fellow journalist Jesse Singal. In this episode, Katie and I chat about where and how she grew up, and what informed her journalistic endeavors. I do grill Katie about some of the crazy stories from her past that I found. We touch briefly on her time working for NPR, and she enlightens me about The Internet Archive, and The Way Back Machine. Then we get into her podcast. Again, it's called Blocked and Reported and she tells me about why she started it, and why she is glad she didn't start it sooner. Finally, we dive into her new book. It doesn't have a name quite yet but should be released around October of 2025. This book chronicles her journey of drinking herself sober. You read that right. That's a very fascinating concept, and she tells me all about how she came to find this path, and why she felt the need to share her experience in the form of her very first book. Make sure you check out her podcast, it is a lot of fun, and be sure to stay tuned for her book around October of 2025.

Thank you for joining us for our 2nd Cabral HouseCall of the weekend! I'm looking forward to sharing with you some of our community's questions that have come in over the past few weeks…   Chrissy: Hi dr Cabral Is it ok to that estrogel and progesterone for menopause if you have lymphoedema ? Or will it make it worse .. kind regards Chrissy                                                                                                                                                    Kay: Hi Dr. Cabral- What are your thoughts on Metformin combined w Naltrexone topiramate and Vit B12 for Tx of PCOS? My 31 y.o. daughter has tried over the last few years to manage her PCOS w traditional Chinese herbs, acupuncture, yoga & pilates which have only given her limited success. Her HbA1c were in the pre-diabetic range. She lives in the NYC area w a demanding job. Now, working w a Functional Med provider, her tests showed high levels of cortisol throughout the day & hormonal imbalances. Weekend hikes & being near nature on occasion have helped her stress levels as shown by her Oura ring data. After about a month of the Rx regimen, she has noticed an improvement in her HbA1c and has hired a personal trainer. For true, sustainable wellness, what do you recommend?                                       Becky: Hi Dr. Cabral! Thank you for ALL that you do and thank you for using your story to help heal others! I am an IHP2 and need advice. I am working with a client, she is in her mid 30s and she has had horrific breath and overall dryness of her entire body since a child. Her dad and siblings have the same issues along with her oldest daughter. She has tried EVERY imaginable product to fix her breath with zero success. She has done the 21 day detox, & is finishing up the CBO Protocol with H.Pylori & will be starting the Finisher. She did a HTMA last year with someone else but nothing alarming. She is hopeless that her breath can't be fixed. What is your suggestion as to what direction we should go next? She does not drink filtered water, is on birth control & an anti depressant. THANKS!!!!            Kayley: I am 24 yrs old 5'2" 123lbs. I have diagnosed Rheumatoid Arthritis that has severely impacted my life. I currently take Methotrexate, Plaquenil, Folic Acid, and Folinic Acid. I am struggling with debilitating fatigue, and my IBS has recently flared up. Is there anything you would suggest doing to improve energy levels?                               Amanda: Does chiropractic treatment benefit children diagnosed with ADHD?     Thank you for tuning into this weekend's Cabral HouseCalls and be sure to check back tomorrow for our Mindset & Motivation Monday show to get your week started off right! - - - Show Notes and Resources: StephenCabral.com/3509 - - - Get a FREE Copy of Dr. Cabral's Book: The Rain Barrel Effect - - - Join the Community & Get Your Questions Answered: CabralSupportGroup.com - - - Dr. Cabral's Most Popular At-Home Lab Tests: > Complete Minerals & Metals Test (Test for mineral imbalances & heavy metal toxicity) - - - > Complete Candida, Metabolic & Vitamins Test (Test for 75 biomarkers including yeast & bacterial gut overgrowth, as well as vitamin levels) - - - > Complete Stress, Mood & Metabolism Test (Discover your complete thyroid, adrenal, hormone, vitamin D & insulin levels) - - - > Complete Food Sensitivity Test (Find out your hidden food sensitivities) - - - > Complete Omega-3 & Inflammation Test (Discover your levels of inflammation related to your omega-6 to omega-3 levels) - - - Get Your Question Answered On An Upcoming HouseCall: StephenCabral.com/askcabral - - - Would You Take 30 Seconds To Rate & Review The Cabral Concept? The best way to help me spread our mission of true natural health is to pass on the good word, and I read and appreciate every review!  

Transforming Alcohol Recovery with the Sinclair Method: A Conversation with Katie LainIn this episode of the Samantha Parker Show, Samantha sits down with Katie Lain, founder of Thrive Alcohol Recovery, to discuss her decade-long struggle with alcohol and how discovering the neuroscience-based Sinclair Method transformed her life. Katie shares her journey from binge drinking to becoming an advocate for medication-assisted treatment and the Sinclair Method, which uses Naltrexone to help reduce alcohol cravings and promote controlled drinking. The episode covers the brain science behind alcohol addiction, the inefficacy of many traditional abstinence-based treatments, and how Katie turned her recovery into a mission-driven business. They also discuss the importance of finding the right treatment, whether it's AA, the Sinclair Method, or another path, and emphasize the need for individual motivation and gradual lifestyle changes for sustainable recovery.00:00 Introduction to the Samantha Parker Show00:21 Katie Lane's Journey with Alcohol01:03 Discovering the Sinclair Method03:37 How the Sinclair Method Works06:10 Effectiveness and Challenges of the Sinclair Method19:20 The Role of Faith and Purpose in Recovery21:08 Life After Alcohol25:26 Hangover Struggles and Daily Challenges25:46 Inspiration Behind Thrive Alcohol Recovery26:20 Documenting the Journey on YouTube26:47 The Evolution of Thrive Alcohol Recovery28:08 Stigma and Labels in Alcohol Recovery30:28 Exploring Different Recovery Options31:36 The Role of Community and Support34:50 Changing Drinking Trends Among Youth36:50 Rapid Fire Questions and Personal Insights42:17 Encouragement and Resources for RecoveryStep into Your Sober Era! Are you ready to embrace a life of clarity and empowerment? ✨ Check out Sam's Sober Club on Substack for journals, tips, community and more [Subscribe Now ➔] Sam's Sober CLUB | Samantha Parker | Substack Want to Work with The Samantha Parker for Content Management CLICK HERE Follow me on TikTok https://www.tiktok.com/@samanthaparkershow YouTube https://www.youtube.com/@thesamanthaparker Instagram https://www.instagram.com/thesamanthaparker/

Welcome back to Ditch the Labcoat. Today's episode dives deep into a topic that's been quietly reshaping lives and families across the globe: gambling addiction. Host Dr. Mark Bonta sits down with Dr. Daniela Lobo, a leading expert in addiction psychiatry, to explore just how dramatically gambling—especially online and sports betting—has surged in prevalence, fueled by intensive marketing and made even more accessible by the pandemic's isolation.Together, Dr. Bonta and Dr. Lobo break down the reality behind those flashy ads and glossy casino images, peeling back the curtain on the true costs of problem gambling. They explore not just the personal financial and mental fallout, but the ripple effects that devastate families, drive up debt, worsen mental health struggles, and even intersect with substance use disorders. As gambling apps, sports betting, and even crypto-trading continue to blur the lines between entertainment and addiction, the doctors unpack why so many young adults—and increasingly, teens—find themselves hooked.Dr. Lobo shares practical insights for recognizing gambling problems, supporting loved ones, and opening honest conversations with kids. Most importantly, they question whether the billions gained in gambling revenue are truly worth the social and health costs we're only beginning to acknowledge.If you've ever wondered what really drives gambling addiction, how to spot it, or what responsible action looks like for individuals and society, you won't want to miss this eye-opening, evidence-based conversation. Let's ditch the lab coat and get real about gambling in our modern age.Episode LessonsGambling Addiction: Not a Choice — A medical disorder with devastating consequences, not a weakness or bad habit.Online Gambling's Rapid Expansion — Pandemic and marketing fueled a surge, making betting more accessible than ever.Marketing Drives Gambling Behaviors — Aggressive ads and sports integration normalize betting, increasing risks across all ages.Health Impact Beyond Money — Gambling harms mental, emotional, and even physical health, adding layers of stress.Younger Generations at Risk — Sports and digital platforms expose youth to gambling without proper safeguards.Overlap With Other Addictions — Gambling often co-occurs with mental health and substance use disorders.Paths to Treatment and Recovery — Counseling, family support, financial planning, and early intervention provide hope.Financial Ruin and Family Toll — Hidden gambling devastates households, with debt triggering further destructive cycles.Policy and Regulation Matter — Weak oversight allows profit-driven expansion while shifting costs to families.Prevention Through Education — Open dialogue and awareness reduce risks, counter marketing, and build resilience.Episode Timestamps03:21 – Addiction's Evolving Forms: Gambling Alert 07:08 – COVID-19's Impact on Gambling Behavior 11:56 – Gambling's Mental and Physical Toll 13:48 – Accessibility Fuels Gambling Issues 18:03 – Teens, Gambling, and Sports Obsession 22:25 – Problem Gambling's Significant Impact 25:36 – Gambling Disorders and Mental Health 29:18 – iGaming Self-Exclusion & Support 30:30 – Supporting Families with Addicted Loved Ones 36:00 – Modern Gambling: Signs and Challenges 39:02 – Gambling and Risk Awareness Conversation 42:33 – Understanding Moderation and Gambling Risks 45:23 – Ethics of Gambling Expansion 47:03 – Cautionary Insights on Gambling AppsDISCLAMER >>>>>>    The Ditch Lab Coat podcast serves solely for general informational purposes and does not serve as a substitute for professional medical services such as medicine or nursing. It does not establish a doctor/patient relationship, and the use of information from the podcast or linked materials is at the user's own risk. The content does not aim to replace professional medical advice, diagnosis, or treatment, and users should promptly seek guidance from healthcare professionals for any medical conditions.   >>>>>> The expressed opinions belong solely to the hosts and guests, and they do not necessarily reflect the views or opinions of the Hospitals, Clinics, Universities, or any other organization associated with the host or guests.    Disclosures: Ditch The Lab Coat podcast is produced by (Podkind.co) and is independent of Dr. Bonta's teaching and research roles at McMaster University, Temerty Faculty of Medicine and Queens University. 

You may recognize Katie Herzog's journalism and podcasting, but did you also know she's soon-to-be famous for her alcoholism? For years she hid it from the world and her exceptionally gullible wife, but now she tells all in a new book which even longtime twelve-stepper Nina finds persuasive. Can you quit booze while happily retaining your character defects? What is Naltrexone? Does everyone get a “buzz” from drinking? Does Nina get pleasure from anything? Plus: amusing recollections of drunken episodes and blackouts, getting older and more isolated, extinguishing desires, AA vs. Al-Anon, Kokomo, Kokomo, why you should never apologize, and tips on how to hide both drinking and smoking from your spouse!Links:Drink Your Way Sober by Katie Herzog: https://www.drinkyourwaysober.com/The Sinclair Method: https://www.sinclairmethod.org/what-is-the-sinclair-method-2/Syn-Anon documentary: https://www.hbomax.com/shows/synanon-fix/a27b5e0a-68eb-48e2-baa6-2b0f01d5b8be Get full access to Heterodorx Podcast at heterodorx.substack.com/subscribe

Katie Herzog, co-host of the Blocked & Reported podcast, returns to Walk-Ins Welcome to discuss her new book Drink Your Way Sober. She and Bridget have a frank conversation about alcoholism, the steps you take to hide it from your loved ones, Katie's realization that it would kill her, and how Naltrexone helped her drink her way sober and banished the desire to drink, something she'd never experienced before. They cover how the drug works, why it won't work for everyone, the difference between drinking habits, reward drinkers vs. relief drinkers, their current addictions, why Perimenopause is just a branding term, driverless cars, Pee-wee Herman, the wild world of Mormon influencers who party without a drop, how to deal with family members who want to read the book you wrote, why as a writer, the impulse to self-protect is weaker than the impulse to tell a good story. Order Katie's book here: https://bit.ly/WiW-DrinkYourWaySober --------------------------------------------------------------------- Sponsor Links: - Quest offers 100+ lab tests to empower you to have more control over your health journey. Choose from a variety of test types that best suit your needs, use code PHETASY to get 25% off - https://www.questhealth.com - In Brad vs. Everyone, host Brad Polumbo covers the most interesting and entertaining stories in our politics and on the internet from a center-right, independent perspective - https://spoti.fi/42KTKTw --------------------------------------------------------------------- Walk-Ins Welcome with Bridget Phetasy - Podcast Bridget Phetasy admires grit and authenticity. On Walk-Ins Welcome, she talks about the beautiful failures and frightening successes of her own life and the lives of her guests. She doesn't conduct interviews—she has conversations. Conversations with real people about the real struggle and will remind you that we can laugh in pain and cry in joy but there's no greater mistake than hiding from it all. By embracing it all, and celebrating it with the stories she'll bring listeners, she believes that our lowest moments can be the building blocks for our eventual fulfillment. ---------------------------------------------------------------------- PHETASY IS a movement disguised as a company. We just want to make you laugh while the world burns. https://www.phetasy.com/ Buy PHETASY MERCH here: https://www.bridgetphetasy.com/ For more content, including the unedited version of Dumpster Fire, BTS content, writing, photos, livestreams and a kick-ass community, subscribe at https://phetasy.com/ Twitter - https://twitter.com/BridgetPhetasy Instagram - https://www.instagram.com/bridgetphetasy/ Podcast - Walk-Ins Welcome with Bridget Phetasy https://itunes.apple.com/us/podcast/walk-ins-welcome/id1437447846 https://open.spotify.com/show/7jbRU0qOjbxZJf9d49AHEh https://play.google.com/music/listen?u=0#/ps/I3gqggwe23u6mnsdgqynu447wvaSupport the show

In this episode, we explore extended-release naltrexone for opioid use disorder, examining its unique role as a pure antagonist in patients who require safety-sensitive careers. How do we successfully navigate the challenging initiation period when patients must be opioid-free for a week? Faculty: Smita Das, M.D. Host: Richard Seeber, M.D. Learn more about our memberships here Earn 1 CME: Pharmacologic Management of Opioid Use Disorder Examining the Efficacy of Extended-Release Naltrexone OUD

In this episode, we explore how to choose between methadone, buprenorphine, and naltrexone for opioid use disorder treatment. With over 100,000 overdose deaths annually, how do we match the right medication to save each patient's life? Faculty: Smita Das, M.D. Host: Richard Seeber, M.D. Learn more about our memberships here Earn 1 CME: Pharmacologic Management of Opioid Use Disorder Tailored Patient Assessment: A Key to Effective OUD Treatment  

Click here to watch this episode on YouTube! If you've ever wondered whether medication could help you drink less — or you've tried naltrexone and felt disappointed — this episode is for you. I'm joined by Katie Lain, founder of Thrive Recovery and a fierce advocate for the Sinclair Method — a science-backed approach that uses naltrexone to reduce alcohol cravings over time. Katie shares her personal story of going from daily binge drinking to finding freedom without needing to get sober. She's also going to explain what most people get wrong about relying on medication alone to change their relationship with alcohol. If you've been stuck in the “gray area” — drinking more than you want to, but not seeing yourself as an alcoholic — you'll love this conversation. You'll walk away with a big-picture understanding of what it takes to rewire the brain for lasting change, and how to move through the messy middle of behavior change without shame, guilt, or black-and-white thinking. Katie Lain is the founder of Thrive Alcohol Recovery. You can find her @thrivealcoholrecovery on YouTube, Instagram, Linked-In and Facebook.  Want daily updates from me? TikTok: @hangoverwhisperer Instagram: @thehangoverwhisperer Twitter (X): @NotAboutTheAlc YouTube: @hangoverwhisperer   Click here to BOOK A DISCOVERY CALL if you're ready to fully commit to your personal growth and do the work to get emotionally sober. Side effects include an 80 percent reduction in drinking.   —Do you want coaching from Colleen on a situation you're struggling with? Click here to submit your question. Your name will not be mentioned on air!  Email  

In this episode of the Sober Motivation Podcast, host Brad welcomes Jane, who shares her compelling journey of growing up surrounded by alcohol, struggling to fit in, and eventually becoming dependent on alcohol herself. She recounts her early experiences with alcohol, the impact of her father's drinking, and her own struggles with binge drinking and blackouts. Jane talks about her attempts to moderate her drinking, the escalation in her twenties and thirties, and the impact on her relationships and motherhood. Despite the normalization of drinking in her circle, Jane eventually seeks help, leading her to Alcoholics Anonymous and ultimately finding sobriety with the help of Naltrexone. Now over two years sober, Jane discusses how she changed her life, started a business, and is helping others, particularly the youth, navigate their own journeys with alcohol.   ----------- Jane's Instagram: https://www.instagram.com/letsgetapedi/

In episode 62 we discuss the article “Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients with Alcohol Use Disorder.” Magane KM, et al.Oral vs Extended-Release Injectable Naltrexone for Hospitalized Patients With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Intern Med. 2025 Jun 1;185(6):635-645. We also discuss reduced overdose deaths and changes in buprenorphine labelling to include higher doses. NPR:Drug deaths plummet among young Americans as fentanyl carnage eases Federal Register:Modifications to Labeling of Buprenorphine-Containing Transmucosal Products for the Treatment of Opioid Dependence --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go tothis link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visitMI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music:composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer:Dr. Patrick Beeman A podcast fromArs Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode, we explore groundbreaking head-to-head research comparing topiramate and naltrexone for alcohol use disorder, revealing surprising equivalence in effectiveness. Could the off-label option actually be as good as our FDA-approved standard for treating problematic drinking? Faculty: David Gorelick, M.D. Host: Richard Seeber, M.D. Learn more about our membership here Earn 0.5 CME: Quick Take Vol. 69 Can Topiramate Replace FDA-Approved Medications for Alcohol Use Disorder?

Listen in as Joseph Kim, MD, MPH, MBA; Manish Shah, MD; Martha Grugel, MA, discuss how they manage the prior authorization process for antiobesity agents to improve the quality of their care delivery, including:The information to collect during patient visitsThe available resources to help you submit prior authorizationsThe supporting documents that are often necessary to accompany prior authorizationsHow to address denials and appealsWhen to access manufacturer-based or foundation-based financial assistancePresentersJoseph Kim, MD, MPH, MBAPresidentQ Synthesis, LLCNewtown, PennsylvaniaManish Shah, MDClinical Associate Faculty MS1 PreceptorUniversity of Florida College of MedicineGainesville, FloridaMartha Grugel, MAMedical AssistantWesley Chapel, FloridaLink to full program: https://bit.ly/45P0v8z

This is a free preview of a paid episode. To hear more, visit smokeempodcast.substack.comNancy and Sarah are joined by Katie Herzog, co-host of the Blocked and Reported podcast and author of an up-and-coming book on quitting booze, Drink Yourself Sober. They talk about getting canceled, navigating public backlash, and why Katie's drinking tale is different from Sarah's — she used Naltrexone, an opioid-blocker, to help quit. They discuss AA, the meaning of the word “alcoholic,” the nature of addiction, and why there's no wrong way to get sober.Also on tap:* Jesse Singal, analyzed* If you walk into the online arena, expect to get gored* Helen Lewis, epic BARpod co-host* Dan Savage is brilliant, but can he help us understand “freak offs”? (Please?)* The Onion was once sold for $10,000?* Andy Mills, top-tier man!* Missing Twitter, pre-Elon* Do NOT type your name into BlueSky * When Katie realized she had a drinking problem* “Science may one day accomplish this, but it hasn't done so yet”* Sarah breastfed until what age?* The Sinclair method* Fun drunk v. sleepy drunk* The tragic death of Jonathan Joss* Sarah was Katie's AA sensitivity reader* Naltrexone, the Ozempic of booze* Sarah learns a new phrase: “pharmacological extinction”* “My life is monumentally better than when I was drinking”* AA founder Bill Wilson = weirder than you think* Writing a recovery book is a weird form of insurance* GETTING FREE* That Salon personal essay Katie can't get off the Internet* Piled on by Milo Yiannapoulos, oh the irony* Katie is fine being cringe* RIP, William LangewiescheSo much wisdom in this podcast, but the best parts are for paid subscribers

In this episode, we discuss the fundamentals of treating opioid and alcohol use disorders with medication-assisted approaches. We review how to understand addiction as self-regulation with substances and how healthcare providers can leverage familiar medications alongside specialized treatments to help patients recover.We also discuss• Addiction fundamentally involves helping patients shift from self-regulating with substances to self-regulating without them• Distinguishing opioid dependence (physical brain chemistry changes) from opioid use disorder (psychological addiction)• Buprenorphine as a partial agonist that blocks other opioids, reduces cravings, and decreases overdose risk by 70%• Three FDA-approved medications for alcohol use disorder: disulfiram , naltrexone, and acamprosate• Off-label medications like gabapentin and topiramate can enhance alcohol use disorder treatment• Understanding the fentanyl crisis and emergence of counterfeit pills containing dangerous synthetic opioids• Addressing stigma through person-first language and recognizing addiction as a disorder of executive functioningTo contact Dr. Grover: ammadeeasy@fastmail.com

Today's episode is for the woman who's doing everything right—and still feels like she's falling apart.   Colleen sits down with Laurie James, somatic coach and author of Sandwiched: A Memoir of Holding On and Letting Go to talk about what happens when your nervous system hits a breaking point. Laurie ended up in the hospital—twice—after leaving a toxic marriage, raising four daughters, dating again, writing a book, and trying to heal.   This is a raw, honest conversation about how success can hide trauma, why “pushing through” is often dissociation in disguise, and how to regulate your nervous system before your body takes matters into its own hands.  

Listen in as our expert panel discusses medications for management of opioid use disorder. They'll review strategies to optimize buprenorphine use and clarify the role of methadone and naltrexone.Special guest:Tyler J. Varisco, PharmD, PhDUniversity of Houston College of Pharmacy Assistant Professor, Department of Pharmaceutical Health Outcomes and PolicyAssistant Director, The PREMIER CenterYou'll also hear practical advice from panelists on TRC's Editorial Advisory Board:Stephen Carek, MD, CAQSM, DipABLM, Clinical Associate Professor of Family Medicine for the Prisma Health/USC School of Medicine Greenville Family Medicine Residency Program at the University of South Carolina School of Medicine, GreenvilleCraig D. Williams, PharmD, FNLA, BCPS, Clinical Professor of Pharmacy Practice at the Oregon Health and Science UniversityFor the purposes of disclosure, Dr. Varisco reports a financial relationship [cardiology, inflammatory bowel disease] with HEALIX Infusion Therapy (research consultant).The other speakers have nothing to disclose.  All relevant financial relationships have been mitigated.This podcast is an excerpt from one of TRC's monthly live CE webinars, the full webinar originally aired in March 2025.TRC Healthcare offers CE credit for this podcast. Log in to your Pharmacist's Letter, Pharmacy Technician's Letter,or Prescriber Insights account and look for the title of this podcast in the list of available CE courses.Claim CreditThe clinical resources mentioned during the podcast are part of a subscription to Pharmacist's Letter, Pharmacy Technician's Letter, and Prescriber Insights: FAQ: Management of Opioid Use DisorderChart: Treatment of Opioid WithdrawalFAQ: Treatment of Acute Pain in Opioid Use DisorderFAQ: Meds for Opioid OverdoseSend us a textIf you're not yet a subscriber, find out more about our product offerings at trchealthcare.com. Follow, rate, and review this show in your favorite podcast app. Find the show on YouTube by searching for ‘TRC Healthcare' or clicking here. You can also reach out to provide feedback or make suggestions by emailing us at ContactUs@trchealthcare.com.

In this compelling episode of the Alcohol Minimalist Podcast, Molly reconnects with Katie Lain, founder of Thrive Alcohol Recovery, to explore the power of neuroscience-based strategies for changing your relationship with alcohol. Katie shares her personal recovery story and how the Sinclair Method, a treatment protocol that uses the medication naltrexone, gave her a new lease on life.This conversation goes beyond the medication to highlight the vital role of mindset, habit formation, and long-term commitment to behavior change. Molly and Katie discuss the real-world challenges people face in recovery, the importance of self-compassion, and how small, sustainable steps create the most lasting transformation.What You'll Learn in This Episode:How the Sinclair Method works and why it's effective for both binge and daily drinkersWhy medication is a support tool, not a standalone solutionThe mental space that opens up when cravings start to fadeThe average timeline to regain control and build a peaceful relationship with alcoholUnique challenges for binge drinkers, including compliance and thought patternsThe critical importance of mindset and identifying unconscious beliefsWhat to expect on the journey: setbacks, progress, and learning to keep goingWhy self-compassion and curiosity are non-negotiables for long-term changeKey Message: Naltrexone can be a powerful part of the journey, but it must be paired with thought work, intentional habit-building, and a willingness to take small steps forward—even after setbacks. There is no one-size-fits-all approach, and both Molly and Katie emphasize that you don't have to wait until alcohol becomes a serious problem to start creating change.Resources Mentioned:Learn more about Thrive Alcohol Recovery: thrivealcoholrecovery.comKatie Lain on YouTube, Instagram, and other social platformsMolly's coaching programs and podcast archive: www.mollywatts.comLet's Connect:Website: www.mollywatts.comInstagram: @alcoholminimalistFacebook: Join the Alcohol Minimalists GroupLow risk drinking guidelines from the NIAAA:Healthy men under 65:No more than 4 drinks in one day and no more than 14 drinks per week.Healthy women (all ages) and healthy men 65 and older:No more than 3 drinks in one day and no more than 7 drinks per week.One drink is defined as 12 ounces of beer, 5 ounces of wine, or 1.5 ounces of 80-proof liquor. So remember that a mixed drink or full glass of wine are probably more than one drink.Abstinence from alcoholAbstinence from alcohol is the best choice for people who take medication(s) that interact with alcohol, have health conditions that could be exacerbated by alcohol (e.g. liver disease), are pregnant or may become pregnant or have had a problem with alcohol or another substance in the past.Benefits of “low-risk” drinkingFollowing these guidelines reduces the risk of health problems such as cancer, liver disease, reduced immunity, ulcers, sleep problems, complications of existing conditions, and more. It also reduces the risk of depression, social problems, and difficulties at school or work. ★ Support this podcast ★

If you've ever been told that birth control is your only option for endometriosis, PMS, or unexplained infertility—you're not alone. In this episode of Cycle Wisdom, Dr. Monica Minjeur explores an unexpected yet powerful tool in restorative reproductive medicine: Low Dose Naltrexone (LDN).LDN was originally developed for opioid addiction, but at much lower doses, it's gaining traction for its ability to regulate the immune system, reduce inflammation, and increase natural endorphins—all without suppressing your body's natural hormone systems.Through the emotional story of Charlotte, a 33-year-old therapist worn down by chronic pain and hormonal chaos, we explore how LDN helped her break free from the cycle of monthly suffering and find renewed hope.Dr. Minjeur dives into:

Dr. Jake explores an innovative, low-risk alternative to traditional steroid treatments for autoimmune conditions: Low Dose Naltrexone (LDN). Originally developed in higher doses for treating addiction, Naltrexone is now showing promising results as an immune modulator at very low doses. Learn how LDN works to calm the immune system, reduce inflammation, and help the body restore balance naturally, without the harsh side effects associated with steroids.What You'll Learn:What is Low Dose Naltrexone (LDN)? A quick background on how it went from addiction treatment to immune modulator.How LDN Helps Autoimmune Conditions: From rheumatoid arthritis to Hashimoto's and beyond—see how it can reduce flare-ups and inflammation.LDN vs. Steroids: Why LDN might be a safer, long-term alternative to steroids for immune regulation.Who Can Benefit? Dr. Jake discusses which autoimmune patients might see the most benefit from LDN therapy.Join Dr. Jake as he dives into the research, shares patient success stories, and explains how LDN could be a life-changing option for those struggling with autoimmune conditions. If you're searching for a gentler approach to manage autoimmunity, this episode is for you!Want to get ahold of Dr Jake? visit us at https://integrativemedica.com

On December 6th, 2023, I made the scariest—and most transformative—decision of my life. I chose to believe in myself. Not in a "feel-good" kind of way, but in a way that demanded action before certainty and courage before confidence. This episode is a personal snapshot from that turning point—a moment when I faced fear, financial dependence, and self-doubt… and decided to move forward anyway.   Today, I'm walking you through the 3 emotional skills that built my resilience—not just for leaving my marriage, but for building a seven-figure business, creating a powerful community, and helping high-achieving women like you change their relationship with alcohol… and themselves.   In this episode, you'll learn:

Naltrexone has been used to treat alcohol use disorder for 30 years, ever since researcher Dr. Joseph Volpicelli identified its effectiveness. In this podcast we are joined by both Dr. Volpicelli and Jonathan Hunt-Glassman, the founder of Oar Health, an organization that supports the combination of medication and psychosocial supports to assist people seeking to change their relationship to alcohol.   Dr. Joseph Volpicelli runs the Volpicelli Center and is a University of Pennsylvania's Medical Scientist Training Program graduate, receiving both his doctorate of medicine and psychology.  In this podcast Jonathan shares his and others personal stories of successfully making changes by using Naltrexone and other supports. For Dr. Volpicelli, it comes down to the medication helping individuals make the best choices for themselves when it comes to alcohol use, and the positive steps that he sees patients make in their recovery journeys.   

I saw a NEW ad on TV claiming that new product from a company called Oar Health was a cure for alcoholism or that it would help someone stop drinking. I looked into it, and first off, it is an OLD medication called Naltrexone, but it was being portrayed as a new treatment. I thought the whole thing was very disingenuous. I had to hop on and give my two cents. Please let me know what you think in the comments. GET THE FULL LIST OF SOURCES FOR FREE AND BECOME A PREMIUM MEMBER ON SUBSTACK: https://rebunked.substack.com Get my New Album “Universal Basic Awesome” with unreleased track and MERCH at https://RebunkedRecords.com ALL THE MUSIC VIDEOS: https://youtube.com/@RebunkedRecords INSTAGRAM: https://www.instagram.com/rebunkednew  TWITTER: https://twitter.com/rebunkednews TELEGRAM: https://t.me/Rebunkednews Start your Heavy Metal Detox: https://TruthTRS.com Tip Jar: https://GiveSendGo.com/Rebunked    Rebunked on Substack: https://Rebunked.substack.com      Rebunked News is happy to shout out: Supercharge your health with the amazing supplements at Chemical Free Body! https://chemicalfreebody.com/?rfsn=7505813.fa2d09  VALUE-FOR-VALUE DONATION: https://Rebunked.news  VENMO: https://account.venmo.com/u/rebunked  CASHAPP: https://cash.app/$rebunked  PAYPAL: https://Paypal.me/Rebunked  T-SHIRTS: https://Rebunked.news/Shirts

I am delighted to have Dr. Jill Valerias, an Alaskan-based practitioner, joining me on the show for a two-part series on low-dose Naltrexone. I have been eager to explore this topic for quite some time, and Dr.Valerias is the perfect expert to guide us. In Part 1, she clarified what low-dose Naltrexone is and explained its uses. In Part 2 today, we dive into its safety, the correct dosages, and lab monitoring. How Low-Dose Naltrexone helps with dermatologic conditions: It dampens or lessens immune reactions It can reduce the sensitivity It alleviates rashes. Dr. Jill Valerius Bio: Dr. Jill Valerius is a dual board-certified physician in Family and Integrative Medicine with an additional certification in Functional Medicine. She has been practicing family medicine for over 20 years and, over time, has realized that focusing on diet, lifestyle, and nutrition are the only ways to treat and avoid chronic diseases effectively. Through listening, educating, and empowering patients, she has been able to help patients reverse and avoid chronic medical problems and unnecessary prescription medications. Her mission is to educate and empower people to avoid and reverse health problems, allowing them to live happy, healthy, and full lives. In This Episode: How LDN works to provide pain relief The immune-modulating effects of LDN How LDN reduces inflammation How LDN impacts sleep, pain, and overall well-being Various autoimmune conditions that LDN can treat   What is the typical dosing regimen for LDN? The tools Dr.Valerius uses to monitor and improve cognitive function in older patients and those she uses to help patients relax and improve their focus     Links and Resources: Use code HEALGUT to get 10% off GI Support Use CODE BERBERINE to get 10% off Berberine Use code COQ10 to get 10% off COQ10 Follow Your Longevity Blueprint  On Instagram| Facebook| Twitter| YouTube | LinkedIn Get your copy of the Your Longevity Blueprint book and claim your bonuses here Find Dr. Stephanie Gray and Your Longevity Blueprint online   Follow Dr. Stephanie Gray  on Facebook| Instagram| Youtube | Twitter | LinkedIn Integrative Health and Hormone Clinic Podcast production by Team Podcast  Guest Social Media Links: Now Health on Facebook Now Health on Instagram   Jill Valerius on Instagram  Relative Links for This Show: LDN Science LDN Research Trust Now Health Your Longevity Blueprint Products: Berberine Support COQ10 GI Support

I am thrilled to have Dr. Jill Valerias, an Alaskan-based practitioner, joining me for a two-part series on low-dose Naltrexone. I've been eager to explore this topic for quite some time, and Dr.Valerias is the perfect expert to guide us. Get ready for a fascinating discussion as we dive into Part 1 today. What can Low Dose Naltrexone be used for? Boosting immunity Chronic pain Fibromyalgia Autoimmune diseases. Dr. Jill Valerius Bio: Dr. Jill Valerius is a dual board-certified physician in Family and Integrative Medicine with an additional certification in Functional Medicine. She has been practicing family medicine for over 20 years and, over time, has realized that focusing on diet, lifestyle, and nutrition are the only ways to treat and avoid chronic diseases effectively. Through listening, educating, and empowering patients, she has been able to help patients reverse and avoid chronic medical problems and unnecessary prescription medications. Her mission is to educate and empower people to avoid and reverse health problems, allowing them to live happy, healthy, and full lives. In This Episode: What is Low Dose Naltrexone (LDN)? What is LDN used for? How Dr.Bahari discovered the concept of using LDN in the 1980s How LDN tricks the body into producing more endorphins to reduce chronic pain and inflammation The benefits of LDN for treating autoimmune conditions Links and Resources: Use code GLUTATHIONE to get 10% off GLUTATHIONE Use code MOOD to get 10% off 5HTP Use code MAGNESIUM to get 10% off MAGNESIUM Follow Your Longevity Blueprint  On Instagram| Facebook| Twitter| YouTube | LinkedIn Get your copy of the Your Longevity Blueprint book and claim your bonuses here Find Dr. Stephanie Gray and Your Longevity Blueprint online   Follow Dr. Stephanie Gray  on Facebook| Instagram| Youtube | Twitter | LinkedIn Integrative Health and Hormone Clinic Podcast production by Team Podcast  Guest Social Media Links: Now Health on Facebook Now Health on Instagram   Jill Valerius on Instagram  Relative Links for This Show: LDN Science LDN Research Trust Now Health Your Longevity Blueprint Products: Glutathione  5 HTP Magnesium Chelate

I am thrilled to reconnect with Esher Blum today. She is an integrative dietitian and menopause expert who has helped 1000s of women master menopause through nutrition, hormones, and self-advocacy. We begin today's conversation by looking at the disparities in menopause care for women, the midlife suit of armor, and the importance of developing mental strength and maintaining bone density. We explore the impact of meno-washing, facial estrogen, foods for menopausal health, and strategies to address facial aging, including peptides, lasers, and collagen peptides. We also dive into carb tolerance, testosterone, and low-dose Naltrexone, and Esther shares her hormone replacement journey and some of the common challenges she sees as an integrative dietitian.  You will love this valuable and insightful conversation with your fan-favorite, Esther Blum. IN THIS EPISODE YOU WILL LEARN: How disparities in menopausal care impact women- especially those in rural areas The difficulties women face in finding capable clinicians to prescribe HRT Esther explains her concept of the midlife suit of armor.  Why women in menopause must maintain their muscle mass How meno-washing gets used in marketing to target products toward menopausal women  The benefits of using vaginal estrogen on the face Various anti-aging techniques and the value of vitamin C, vitamin A, and peptide therapies for skin health Why women in perimenopause and menopause must consume enough protein to build muscle, maintain bone density, and support cognitive function How hormonal changes in menopause disrupt the microbiome  How testosterone can improve women's mood, energy, and body composition Connect with Cynthia Thurlow   Follow on Twitter Instagram LinkedIn Check out Cynthia's website Submit your questions to support@cynthiathurlow.com Connect with Esther Blum On her website   On Instagram Esther's Trainings Previous Episodes Mentioned: Ep. 264 Peri/Menopause as a Natural Function of Aging: See you later, Ovulator! with Esther Blum Ep. 334 Hormone Insights: Advocacy, Trends, and Tips for 2024 with Esther Blum

Today, I have the privilege of connecting with an exceptional friend and colleague, McCall McPherson!  McCall's profound expertise in thyroid health has paved the way for a revolutionary approach to functional medicine. As the visionary behind the cutting-edge Modern Thyroid Clinic in Austin, Texas, and a former TEDx speaker, she joins me to discuss the intricate differences between Grave's Disease and Hashimoto's.  In this episode, we also delve into the unique treatment methods of the Modern Thyroid Clinic and the crucial role of comprehensive lab work support. Our conversation ventures into disordered eating, the detrimental effects of yo-yo dieting, and the starvation diet mentality, emphasizing the significance of metabolic potency. We also explore the impact of synthetic oral contraceptives, the importance of informed consent in hormone resets, and the merits of hormone replacement therapy.  My discussion with McCall encompasses a wide range of strategies that include the utilization of low-dose Naltrexone, GLP-one agonists, fasting techniques, and the pervasive effects of fear-driven food restrictions and weight loss resistance.  Join me as I share our enlightening conversation that promises to leave you informed and inspired! IN THIS EPISODE YOU WILL LEARN: What is Grave's Disease, and how is it treated? What are the symptoms of Grave's Disease? What they do at the Modern Thyroid Clinic to reduce Grave's antibodies. How Naltrexone acts in the body, and what it does for thyroid patients. McCall discusses the supplements she uses for thyroid and explains why she will not use compounded thyroid medication. How disordered eating has crept into the intermittent fasting space. How the hormonal shifts during perimenopause can lead to weight gain. Why is it essential to allow blood sugar to drop, retrain itself, and tap into your fat stores? McCall discusses the labs she prefers using for individuals with some degree of weight loss resistance or presumed metabolic inflexibility. What is the net impact of oral contraceptives? Some common reasons for women becoming weight loss resistant. McCall shares her perspective on iodine. About McCall McCall McPherson is the Founder of Modern Thyroid Clinic, a thyroid-centered functional medicine practice in Austin, Texas, and the owner and Chief-Hope-Giver of Thyroid Nation. She is a physician assistant, TEDx speaker, and thyroid expert by way of being a thyroid patient. Her passion is helping women rebuild their lives from the devastating effects of thyroid and hormonal disorders. Her philosophy is simple: There is no reason to still have thyroid symptoms. Connect with Cynthia Thurlow Follow on Twitter Instagram LinkedIn Check out Cynthia's website Connect with McCall McPherson On her website On Facebook TikTok YouTube Instagram Sign up for McCall's courses

Katie HerzogTake a walk with me down Fascination Street as I get to know Katie Herzog. Katie is a well-known and respected journalist who has written for publications including: The Stranger, The Atlantic, Reason, Medium, and more. She is also a co-host of the very popular podcast Blocked and Reported; with her friend and fellow journalist Jesse Singal. In this episode, Katie and I chat about where and how she grew up, and what informed her journalistic endeavors. I do grill Katie about some of the crazy stories from her past that I found. We touch briefly on her time working for NPR, and she enlightens me about The Internet Archive, and The Way Back Machine. Then we get into her podcast. Again, it's called Blocked and Reported and she tells me about why she started it, and why she is glad she didn't start it sooner. Finally, we dive into her new book. It doesn't have a name quite yet but should be released around October of 2025. This book chronicles her journey of drinking herself sober. You read that right. That's a very fascinating concept, and she tells me all about how she came to find this path, and why she felt the need to share her experience in the form of her very first book. Make sure you check out her podcast, it is a lot of fun, and be sure to stay tuned for her book around October of 2025.

Are you curious to know if plant medicines like psilocybin and pharmaceuticals like naltrexone can reduce your cravings for alcohol?   For women who live and work in mainstream America, the fear of flying to Costa Rica for a psychedelic ceremony ranks right below the fear of telling your doctor how much you really drink.    And so we hide. Because the truth could cost us our career or our kids, force us into expensive rehabs and brand us as alcoholics for the rest of our lives.   Today I'm talking to Amy Devenny, a hairdresser turned activation coach who struggled for years to control her drinking. She's tried staying sober for years at a time, microdosing with psilocybin and most recently, taking naltrexone.   We're having a radically raw conversation about the steps we must take to help ourselves and what it really looks like to overcome alcohol use disorder.   For more information on how to access Naltrexone legally from a board-certified physician through the privacy of an on-line service, listen to It's Not About the Alcohol EP119 Is naltrexone effective in alcohol dependence?   Click here to TAKE THE QUIZ: Do you have a drinking problem or a thinking problem?   You might also enjoy EP25 Plant Medicines Psilocybin and Ayahuasca for Alcohol Use Disorder with Omar Pinto   Find Amy @amydevennyrocks on Instagram   What daily updates from me? Find me on TikTok @hangoverwhisperer and IG @thehangoverwhisperer     If you're ready to fully commit to your personal growth and do the work to get emotionally sober (side effects include an 80 percent reduction in drinking), click here to BOOK A DISCOVERY CALL. You'll walk away from our call with a clear understanding of how to get the skills you need to transform your life.  

Broadcast from KSQD, Santa Cruz on 11-07-2024: Dr. Dawn opens with a guided deep breathing exercise to help listeners manage stress and maintain emotional balance in challenging times. She helps an emailer understand a stress test result for a 72-year-old patient, explaining ST changes, ischemia, and the importance of follow-up angiography tests for heart health evaluation. The show addresses another email from a listener asking for advice about managing alcohol use in an 85-year-old dementia patient. Dr. Dawn discusses medical detox options and medications like Naltrexone for treatment. Dr. Dawn explores the use of low-dose Naltrexone for chronic pain management, particularly in diabetic neuropathy and fibromyalgia. She discusses cataract formation risks associated with St. John's Wort and also mentions the adverse interaction between prostate medications and cataract surgery which increases the risk of complications. Make sure your ophthalmologist knows you are on prostate medications The show features an in-depth explanation of A1 versus A2 milk proteins, their digestive impacts, and potential inflammatory effects in the body. Dr. Dawn concludes with groundbreaking research on creating viable oocytes from stem cells in mice, discussing implications for future fertility treatments.

Broadcast from KSQD, Santa Cruz on 11-07-2024: Dr. Dawn opens with a guided deep breathing exercise to help listeners manage stress and maintain emotional balance in challenging times. She helps an emailer understand a stress test result for a 72-year-old patient, explaining ST changes, ischemia, and the importance of follow-up angiography tests for heart health evaluation. The show addresses another email from a listener asking for advice about managing alcohol use in an 85-year-old dementia patient. Dr. Dawn discusses medical detox options and medications like Naltrexone for treatment. Dr. Dawn explores the use of low-dose Naltrexone for chronic pain management, particularly in diabetic neuropathy and fibromyalgia. She discusses cataract formation risks associated with St. John's Wort and also mentions the adverse interaction between prostate medications and cataract surgery which increases the risk of complications. Make sure your ophthalmologist knows you are on prostate medications The show features an in-depth explanation of A1 versus A2 milk proteins, their digestive impacts, and potential inflammatory effects in the body. Dr. Dawn concludes with groundbreaking research on creating viable oocytes from stem cells in mice, discussing implications for future fertility treatments.

Join us as we review recent practice-changing articles on preventive PCI, andexanet alfa for ICH, aspirin for fatty liver, naltrexone in cirrhosis, pivmecillinam for UTI, cefepime vs pip-tazo, MDRO decolonization, microplastics and MACE, and more! Fill your brain hole with a delicious stack of hotcakes! Featuring Paul Williams (@PaulNWilliamz), Rahul Ganatra (@rbganatra), Nora Taranto (@norataranto) and Matt Watto (@doctorwatto). Claim CME for this episode at curbsiders.vcuhealth.org! Episodes | Subscribe | Spotify | Swag! |Mailing List | Contact | CME! Credits Written and Hosted by: Rahul Ganatra MD, MPH; Nora Taranto MD; Paul Williams, MD, FACP, Matthew Watto MD, FACP Cover Art: Matthew Watto MD, FACP Reviewer: Rahul Ganatra MD, MPH; Emi Okamoto MD Technical Production: Pod Paste Showrunners: Matthew Watto MD, FACP; Paul Williams MD, FACP Show Segments Intro, disclaimer Preventive PCI Andexanet alfa for ICH Aspirin for MASLD Naltrexone for AUD in cirrhosis Pivmecillinam for UTI MDRO decolonization Cefepime vs pip/tazo Microplastics Pax-NO-vid Outro Sponsor: Freed You can try Freed for free right now by going to freed.ai. And listeners of Curbsiders can use code CURB50 for $50 off their first month. Sponsor: ACP MKSAP Learn more about ACP MKSAP at acponline.org/acpmksap  Sponsor: Litter Robot  Whisker is currently offering $50 off Litter-Robot bundles. As a special offer to listeners of the show, go tostopscooping.com/CURB and use promo code CURB to save an additional $50 on any Litter-Robot bundle.

Andy Mills' new podcast Reflector is now available. Episode 1 concerns Naltrexone, a drug that actually works to stop alcohol cravings, and yet 12-Step programs are much more popular, despite being much less effective. He also talks about media capture and the great podcast fake enthusiasm epidemic. Produced by Joel Patterson and Corey Wara Email us at thegist@mikepesca.com To advertise on the show, visit: https://advertisecast.com/TheGist Subscribe to The Gist Subscribe: https://subscribe.mikepesca.com/ Follow Mikes Substack at: Pesca Profundities | MikePesca | Substack Learn more about your ad choices. Visit podcastchoices.com/adchoices