Podcasts about jama psychiatry

What if the reason so many of us are struggling right now isn't a lack of success… but a lack of connection to something deeper?Dr. Lisa Miller is a clinical psychologist, professor at Columbia University, and author of The Awakened Brain, and her research challenges something many of us have been taught to overlook: that spirituality isn't optional, and it isn't just religion… it's a core part of how we're wired. Her journey began at 26, on an inpatient psychiatric unit, where she watched the best available treatments fall short for people in their darkest moments. When the unit had no clergy for Yom Kippur, she showed up with her grandmother's prayer book and led a service in the back hall… and watched patients who had been despairing for months sit up, brighten, and begin to heal. That day set her on a 30-year scientific quest.What she found reframes how we think about mental health. Buried in the back of large national data sets was a single question: how personally important is spirituality or religion to you? When Dr. Miller ran the numbers, a strong personal spirituality, with or without religion, turned out to be 80% protective against addiction and 82% protective against completed suicide — more protective against the diseases of despair than anything else known to the clinical sciences. Twin studies show this capacity is one-third innate and two-thirds environmentally formed, which means every one of us is born with it, and every one of us can strengthen it. Her MRI research, published in JAMA Psychiatry, found that a sustained spiritual life builds cortical thickness across the regions of the awakened brain, protecting against the recurrence of depression.In this conversation with Dr. Michael Gervais, Lisa walks through the difference between achieving awareness and awakened awareness, the three neural circuits behind feeling loved, guided, and never alone, and how parents and leaders can put this science to work. Mike opens up about his own path… the early pull he felt toward a spiritual life, the pendulum swing toward achievement, and the hypocrisy he witnessed as a teenager that nearly cost him his connection to what Lisa calls the flame.In this conversation, we explore:Why spirituality is an inborn capacity, not a beliefThe single research finding that reframes how we think about mental healthThe difference between the achieving brain and the awakened brainThe three neural circuits behind feeling loved, guided, and never aloneWhy a sustained spiritual life physically strengthens the brainHow parents can support a child's natural spiritual awarenessWhy 90% of leaders made the most important decision of their lives through an awakened form of knowingHow to heal from spiritual injury when a bad messenger breaks your trustIf you've ever felt successful on paper but disconnected in your life, this conversation offers a science-backed way back to something deeper.Links & ResourcesThis episode is brought to you in part by our partner, Sunlighten, the company that has pioneered infrared sauna technology. Go to https://findingmastery.com/sunlighten to see how you can save up to $2,100 on their mPulse Intelligent Sauna.Subscribe to our Youtube Channel for more conversations at the intersection of high performance, leadership, and wellbeing: https://www.youtube.com/c/FindingMasteryGet exclusive discounts and support our amazing sponsors!Go to: https://findingmastery.com/sponsors/Subscribe to the Finding Mastery newsletter for weekly high performance insights: https://www.findingmastery.com/newsletterDownload Dr. Mike's Morning Mindset Routine: findingmastery.com/morningmindsetFollow on YouTube, Instagram, LinkedIn, and XDr. Lisa Miller's Books: The Awakened Brain and The Spiritual ChildSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Interview with Husseini K. Manji, MD, author of The 25-Year Evolution of Lithium as a Disease-Modifying Agent in Dementia: A Narrative Review. Hosted by John Torous, MD. Related Content: The 25-Year Evolution of Lithium as a Disease-Modifying Agent in Dementia

What if the same symptoms we see in combat veterans — the broken sleep, the irritability, the brain fog — were already quietly spreading through the healthiest, highest-performing people you know?In this episode of Health Longevity Secrets, Robert Lufkin MD sits down with Neil Markey — a former US Army Special Operations captain from the 75th Ranger Regiment turned McKinsey consultant, now the co-founder and CEO of Beckley Retreats and a Harvard Chan School student researching psychedelic-assisted integrated health. Neil walks us through his own journey out of post-combat trauma, the neuroscience of why psilocybin opens a rare window of neuroplasticity in the adult brain, and why he believes this work belongs upstream as preventative medicine for the well.CHAPTERS:00:00 — Introduction02:34 — From Mathlete to 75th Ranger Regiment02:50 — Iraq, WMDs, and the Pretense of War03:16 — Two Afghanistan Tours as a Ranger Captain07:14 — How Meditation Reached Him First11:49 — The Peer Group Where Everyone Was Secretly Breaking12:25 — Why the Environment Always Wins15:15 — The Neuroplasticity Window Psychedelics Open17:18 — Amanda Feilding and the Beckley Foundation18:20 — Why Set and Setting Decide the Outcome20:58 — The Fresh Snowfall Metaphor for the Brain24:09 — Preventative Medicine for the Well, Not Just the Broken32:18 — The Real Safety Profile of Psilocybin33:27 — Beckley as a Public Benefit Corporation39:38 — Bringing Rigor at Harvard Chan40:12 — Jamaica, the Netherlands, and the US Legal Path45:04 — A Green Beret's Son Finally Came to Him46:34 — Why Awe Beats BurnoutKEY TAKEAWAYS:• Psilocybin opens a measurable window of neuroplasticity in the adult brain• Set, setting, and integration determine outcomes far more than the compound itself• Psilocybin is non-toxic with low incident rates when used in controlled environments• The "betterment of the well" use case may be as transformative as clinical treatment• Oregon and Colorado have legalized supervised use; New Mexico and Massachusetts are next• Chronic stress in high-performers replicates many PTSD-like symptoms• Awe, empathy, and connection are measurable outcomes — and they beat burnoutSTUDIES & SOURCES MENTIONED:• Neil Markey — Beckley Retreats (use code LUFKIN for 10% off)• Beckley Foundation — Amanda Feilding's psychedelic research institute• Dr. Robin Carhart-Harris — UCSF Psychedelics Division• Johns Hopkins Center for Psychedelic & Consciousness Research• Oregon Psilocybin Services — first US regulated program• JAMA Psychiatry meta-analysis on psilocybin for depression (2023)• Harvard T.H. Chan School of Public Health⭐ Enjoying the show? Please leave a 5-star review on Apple Podcasts — it takes 30 seconds and helps more people discover the science of health and longevity. Thank you!New episodes every Tuesday & Thursday. Subscribe so you don't miss one.Continue this conversation on Substack: https://robertlufkinmd.substack.comLies I Taught In Medical School — Free sample chapter: https://www.robertlufkinmd.com/lies/Web: https://www.robertlufkinmd.comYouTube: https://www.youtube.com/robertlufkinmdX: https://x.com/robertlufkinmdInstagram: https://www.instagram.com/robertlufkinmd/TikTok: https://www.tiktok.com/@robertlufkinLinkedIn: https://www.linkedin.com/in/robertlufkinmd/

What if the anxiety, overthinking, people pleasing, emotional shutdown, hypervigilance, burnout, and relationship struggles you experience today… were never actually "you" to begin with? In this deeply personal and profoundly eye-opening solo episode, Darin Olien dives into the hidden nervous system programming formed between the ages of 0 and 8 that silently shapes our adult lives. Drawing from neuroscience, trauma research, attachment theory, epigenetics, somatic healing, and his own emotional breakthroughs, Darin explores how childhood experiences become subconscious operating systems that influence everything from relationships and stress responses to chronic disease and self-worth. This episode is a powerful roadmap toward healing. Darin breaks down the science behind trauma, the ACE study, nervous system dysregulation, emotional patterning, and neuroplasticity, while also sharing practical tools like somatic experiencing, expressive writing, EMDR, and Internal Family Systems to help listeners begin rewiring their emotional lives from the inside out. What You'll Learn How childhood experiences program the nervous system Why most adult emotional reactions are subconscious survival patterns The connection between trauma, stress hormones, and chronic disease How the nervous system stores emotional experiences in the body Why people pleasing, hypervigilance, burnout, and emotional shutdown develop The science behind neuroplasticity and rewiring the brain What the ACE Study revealed about childhood trauma and adult health How trauma impacts the amygdala, hippocampus, and stress-response systems Why emotional patterns are adaptations, not character flaws How epigenetics can pass trauma responses across generations The role of somatic experiencing in trauma healing Practical tools for emotional regulation and nervous system repair Chapters 00:00:03 – Welcome to SuperLife 00:00:32 – Sponsor: Bite Toothpaste and eliminating toxic plastic exposure 00:02:47 – Darin introduces emotional reactions and nervous system triggers 00:03:15 – A personal story about reacting vs responding in conflict 00:03:50 – Emotional shutdowns, rage, withdrawal, people pleasing, and overcorrection 00:04:19 – Darin's physical pain journey and emotional discoveries in 2025 00:04:42 – Birth trauma, childhood conditioning, and nervous system programming 00:05:04 – Why the ages of 0–8 are the most neurologically influential years 00:05:18 – Theta and delta brainwave states during childhood 00:05:55 – How children absorb emotional patterns without filters 00:06:22 – Childhood experiences becoming subconscious operating systems 00:06:44 – Adults unknowingly living through a 5-year-old nervous system 00:07:12 – Why this episode became deeply personal for Darin 00:07:35 – The neuroscience behind stress responses and emotional conditioning 00:08:17 – Brain development, neuroplasticity, and subconscious programming 00:09:13 – How the HPA axis, amygdala, and prefrontal cortex are shaped early in life 00:09:45 – Core childhood questions that program the nervous system 00:10:29 – Why adult stress responses originate in childhood environments 00:11:05 – Research showing childhood adversity alters brain structure and chemistry 00:11:18 – The ACE Study explained 00:11:49 – Why patients losing weight became emotionally overwhelmed 00:12:18 – The ten categories of adverse childhood experiences 00:13:02 – "The health crisis of America begins in childhood" 00:13:36 – How adverse childhood experiences increase disease risk 00:14:03 – Suicide, alcoholism, autoimmune disease, depression, and trauma correlations 00:14:37 – Chronic disease as a nervous system issue 00:15:04 – Survival mode, inflammation, hormonal dysregulation, and emotional scarcity 00:15:42 – Self-sabotage and emotional coping patterns explained 00:16:02 – Why your emotional patterns are not character flaws 00:16:22 – Childhood survival adaptations and nervous system intelligence 00:16:52 – Hypervigilance, people pleasing, rage, emotional shutdown, and fear 00:17:05 – Sponsor: Manna Vitality and frequency-based wellness 00:18:59 – Epigenetics and inherited trauma responses 00:19:22 – Cortisol regulation genes and hyperactive stress responses 00:19:51 – Holocaust survivors, inherited trauma, and generational nervous systems 00:20:19 – Why healing requires nervous system awareness—not just intellectual understanding 00:20:45 – "You were never supposed to get over it—you were supposed to heal from it" 00:21:01 – Real-life examples of subconscious nervous system programming 00:21:16 – Why receiving compliments can feel unsafe 00:21:30 – Darin's personal struggle with overachievement and scarcity programming 00:22:03 – Emotional neglect, chronic striving, and feeling "not enough" 00:22:16 – The nervous system roots of burnout and exhaustion 00:22:23 – Hair-trigger emotional reactions and hyperactive amygdala responses 00:22:38 – Chronic self-abandonment and losing personal boundaries 00:22:52 – Fear of intimacy, trust issues, and emotional safety 00:23:02 – "The body keeps the score" explained 00:23:22 – Trauma stored in posture, breath, digestion, immunity, and emotional regulation 00:23:43 – Harvard research on trauma-related brain changes 00:24:19 – The radical power of neuroplasticity and nervous system rewiring 00:24:48 – Why healing requires conscious participation 00:25:01 – Darin shares how healing changed decades of emotional pain 00:25:33 – Somatic Experiencing and Peter Levine's trauma work 00:25:57 – How animals discharge stress naturally 00:26:23 – Trauma as incomplete physiological responses frozen in the body 00:26:42 – Why humans suppress emotional discharge 00:27:16 – PTSD research and the effectiveness of somatic experiencing 00:27:41 – A step-by-step somatic grounding practice 00:28:14 – Why healing is more powerful with a regulated person beside you 00:28:38 – EMDR and reprocessing traumatic experiences 00:28:55 – Internal Family Systems and the "parts" inside the psyche 00:29:13 – Inner critics, overachievers, and nervous system adaptations 00:29:39 – Compassionately listening to emotional parts instead of suppressing them 00:29:51 – Expressive writing as a trauma healing practice 00:30:22 – The neuroscience behind emotional journaling 00:30:48 – A four-day expressive writing protocol for healing 00:31:05 – "You are not broken" 00:31:16 – Reprogramming the nervous system through love and safety 00:31:37 – Why deep healing happens in the presence of another regulated person 00:31:52 – Darin considers creating a future healing workshop 00:32:04 – Final reflections: "You are not what happened to you" 00:32:12 – Peace. Love. SuperLife. Thank You to Our Sponsors Bite Toothpaste: Go to trybite.com/DARIN20 or use code DARIN20 for 20% off your first order Manna Vitality: Go to mannavitality.com/ and use code DARIN12 for 12% off your order. Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien     Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness Key Takeaway "The emotional patterns, fears, reactions, and coping mechanisms that run your adult life are often survival adaptations created by your nervous system during childhood. They are not your identity. They are not permanent. And through awareness, somatic healing, emotional processing, nervous system regulation, and conscious repetition, those deeply rooted patterns can be rewritten into something healthier, freer, and more aligned with who you truly are." Bibliography/Sources Neuroscience & Early Programming Agorastos, A., Pervanidou, P., Chrousos, G. P., & Baker, D. G. (2019). Developmental trajectories of early life stress and trauma: A narrative review on neurobiological aspects beyond stress system dysregulation. Frontiers in Psychiatry, 10, Article 118. https://doi.org/10.3389/fpsyt.2019.00118 Bolton, J. L., Short, A. K., Simeone, K. A., Daglian, J., & Baram, T. Z. (2019). Programming of stress-sensitive neurons and circuits by early-life experiences. Frontiers in Behavioral Neuroscience, 13, Article 30. https://doi.org/10.3389/fnbeh.2019.00030 Shonkoff, J. P., & Boyce, W. T. (2024). Toxic stress and developmental programming of the HPA axis. Annual Review of Developmental Psychology. https://www.annualreviews.org/journal/devpsych Teicher, M. H., & Ohashi, K. (2023). Childhood trauma and reduced hippocampal, anterior cingulate, and corpus callosum volumes. JAMA Psychiatry. https://jamanetwork.com/journals/jamapsychiatry van der Kolk, B. A. (2014). The body keeps the score: Brain, mind, and body in the healing of trauma. Viking / Penguin. https://www.penguinrandomhouse.com/books/313183/the-body-keeps-the-score-by-bessel-van-der-kolk-md/ ACE Study & Adverse Childhood Experiences Felitti, V. J. (2002). The relation between adverse childhood experiences and adult health: Turning gold into lead. The Permanente Journal, 6(1), 44–47. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112216/ Felitti, V. J., & Anda, R. F. (2010). The relationship of adverse childhood experiences to adult health, well-being, social function, and healthcare. In R. Lanius, E. Vermetten, & C. Pain (Eds.), The impact of early life trauma on health and disease (pp. 77–87). Cambridge University Press. https://doi.org/10.1017/CBO9780511777042 Hillis, S., Mercy, J., Amobi, A., & Kress, H. (2023). Economic burden of health conditions associated with adverse childhood experiences among U.S. adults. JAMA Network Open, 6(12). https://jamanetwork.com/journals/jamanetworkopen Liu, Y., Croft, J. B., Chapman, D. P., et al. (2013). Associations between adverse childhood experiences and health outcomes in adults aged 18–59 years. PLOS ONE, 8(3), e58625. https://doi.org/10.1371/journal.pone.0058625 Epigenetics & Trauma Baratta, M. V., et al. (2021). Epigenetics of childhood trauma: Long term sequelae and potential for treatment. Neuroscience & Biobehavioral Reviews, 132, 1049–1063. https://doi.org/10.1016/j.neubiorev.2021.09.043 Jiang, S., Postovit, L., Cattaneo, A., Binder, E. B., & Aitchison, K. J. (2019). Epigenetic modifications in stress response genes associated with childhood trauma. Frontiers in Psychiatry, 10, Article 808. https://doi.org/10.3389/fpsyt.2019.00808 Provençal, N., & Binder, E. B. (2015). The effects of early life stress on the epigenome: From the womb to adulthood and even before. Experimental Neurology, 268, 10–20. https://doi.org/10.1016/j.expneurol.2014.12.001 Healing Modalities — Research Brom, D., Stokar, Y., Lawi, C., et al. (2017). Somatic experiencing for posttraumatic stress disorder: A randomized controlled outcome study. Journal of Traumatic Stress, 30(3), 304–312. https://doi.org/10.1002/jts.22189 Fratarolli, J. (2006). Experimental disclosure and its moderators: A meta-analysis. Psychological Bulletin, 132(6), 823–865. https://doi.org/10.1037/0033-2909.132.6.823 Gilbert, P. (2009). The compassionate mind: A new approach to life's challenges. New Harbinger Publications. https://www.newharbinger.com/9781572248403/the-compassionate-mind/ Justice Resource Institute. (2022). Evaluation of the efficacy of Internal Family Systems (IFS) therapy for trauma-related symptoms among complexly traumatized adults. ClinicalTrials.gov Identifier: NCT05155930. https://clinicaltrials.gov/ct2/show/NCT05155930 Kuhfuß, M., Maldei, T., Hetmanek, A., & Baumann, N. (2021). Somatic experiencing — effectiveness and key factors of a body-oriented trauma therapy. European Journal of Psychotraumatology, 12(1), Article 1929023. https://doi.org/10.1080/20008198.2021.1929023 Levine, P. A. (2010). In an unspoken voice: How the body releases trauma and restores goodness. North Atlantic Books. https://www.northatlanticbooks.com/shop/in-an-unspoken-voice/ Neff, K. D., & Germer, C. K. (2013). A pilot study and randomized controlled trial of the Mindful Self-Compassion Program. Journal of Clinical Psychology, 69(1), 28–44. https://doi.org/10.1002/jclp.21923 Pennebaker, J. W. (1997). Writing about emotional experiences as a therapeutic process. Psychological Science, 8(3), 162–166. https://doi.org/10.1111/j.1467-9280.1997.tb00403.x Rodenburg, R., Benjamin, A., de Roos, C., Meijer, A. M., & Stams, G. J. (2009). Efficacy of EMDR in children: A meta-analysis. Clinical Psychology Review, 29(7), 599–606. https://doi.org/10.1016/j.cpr.2009.06.008 Schwartz, R. C. (2021). No bad parts: Healing trauma and restoring wholeness with the Internal Family Systems model. Sounds True. https://www.soundstrue.com/products/no-bad-parts Shapiro, F. (2017). Eye movement desensitization and reprocessing (EMDR) therapy: Basic principles, protocols, and procedures (3rd ed.). Guilford Press. https://www.guilford.com/books/Eye-Movement-Desensitization-and-Reprocessing/Francine-Shapiro/9781462532766  

Você sabia que o animal com o sistema hormonal mais parecido com o da mulher é o elefante fêmea? E que os hormônios não afetam só o corpo — eles mudam quem você acredita que é?Neste episódio falamos de verdade sobre o que acontece com o seu corpo e o seu humor ao longo do ciclo menstrual, da gravidez, do pós-parto e da menopausa. Sem julgamento. Com ciência.O que você vai aprender:→ As 4 fases do ciclo e como cada uma muda sua personalidade, memória e desejo→ Por que o estrogênio afeta a serotonina — e o que isso tem a ver com a pia suja→ O que é matrescence e por que ninguém fala sobre isso→ Como a névoa mental da menopausa tem base neurológica documentada→ Um exercício de 30 dias para mapear seu próprio ritmo emocionalReferências citadas: Journal of Affective Disorders (2023), JAMA Psychiatry (2023), Developmental Cognitive Neuroscience (2022), pesquisadora Lisa Mosconi (The XX Brain).Esse episódio é para você que cansou de se perguntar "o que há de errado comigo?" — e quer começar a perguntar "o que meu corpo está me dizendo?"Compartilhe com uma amiga que precisa ouvir isso.

We've been taught that pain always means something is broken, but it's often just a "stuck" danger signal in the brain. To show us how to turn that signal off, Jill Stoddard talks with Alan Gordon, the founder of the Pain Psychology Center and author of The Way Out. Drawing on his own recovery from chronic pain, Alan explains how fear and conditioning keep us hurting even after we've healed.Through fascinating stories like the "construction worker" case and MRI surprise, they dive into the science of neuroplastic pain and the tools you can use to retrain your nervous system, build stress tolerance, and finally feel safe in your own body again.Listen and Learn:Alan's personal frustration with navigating a broken medical system and how that led to the discovery of a groundbreaking mind-body approach that offers lasting relief for chronic painHow your brain can misinterpret emotional stress or past memories as physical danger to create real, persistent pain even after an injury has fully healed The specific clues that can reveal whether your chronic physical pain is actually coming from your brain, and how to break the cycle of fear that keeps symptoms alive The reason why traditional recovery methods can fail when we ignore our internal state, and how "backward engineering" your physical tension can signal to your brain that the danger has passed Why the clinical evolution of Pain Reprocessing Therapy shifted from exploring unconscious emotions to targeting the brain's internal danger signals, and how modern neuroscience identifies the hidden driver keeping your physical symptoms alive Why somatic tracking outperforms traditional mindfulness Resources:The Way Out: A Revolutionary, Scientifically Proven Approach to Healing Chronic Pain https://bookshop.org/a/30734/9780593086858 Pain Psychology Center Website: https://painpsychologycenter.com/Follow the Pain Psychology Center on Social Media: https://instagram.com/thepainpsychologycenterhttps://www.facebook.com/painpsychologycenterTell Me About Your Pain - Podcast: https://podcasts.apple.com/us/podcast/tell-me-about-your-pain/id1503847664 The Pain Reprocessing Therapy Podcast: https://podcasts.apple.com/us/podcast/pain-reprocessing-therapy-podcast/id1785564399 TEDxAdelaide - Lorimer Moseley - Why Things Hurt: https://www.youtube.com/watch?v=gwd-wLdIHjsAbout Alan GordonAlan Gordon is the creator of Pain Reprocessing Therapy (PRT) and founder of the Pain Psychology Center. He developed PRT through years of clinical practice and research, and its efficacy has been validated in randomized controlled trials published in JAMA Psychiatry. He is the author of The Way Out: A Revolutionary, Scientifically Proven Approach to Healing Chronic Pain.Related Episodes:39. Chronic Pain with Adrianne Sloan75. Mindful Self-Compassion with Christopher Germer114. Way of Effortless Mindfulness with Loch Kelly155. Mindfulness and Recovery with Rebecca Williams177. Mind-Body Practices for Stress and Overwhelm with Rebekkah LaDyne201. Fierce Compassion with Kristin Neff336. Mindfulness and Living Expansively with Sharon Salzberg364. The Brain-Gut Connection with Megan RiehlSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Today's Headlines: Spirit Airlines quietly ceased to exist overnight Saturday — no warning, no functioning customer service, just stranded pilots, crew members, and passengers. The real culprit is fuel costs, which are also why you're paying $4.45/gallon nationally and Californians are staring down $6+ at the pump — up over a dollar from a year ago. Speaking of costs, Trump's war with Iran rolls on: he told Congress Friday that hostilities are officially "terminated" thanks to an April ceasefire, while simultaneously keeping a full naval blockade running in the Strait of Hormuz because Iran still poses a "significant threat" — and could "misbehave." A British cargo ship was attacked in the strait yesterday, Iran is playing toll booth operator for non-US ships, and actual diplomats are quietly exchanging drafts of a peace framework while Trump posts on Truth Social that Iran "has not yet paid a big enough price." He also mentioned, fairly casually, that the US will be taking over Cuba "almost immediately," so stay tuned. Back home, a federal appeals court froze the rule allowing abortion medication to be prescribed via telehealth and shipped to patients — a major win for the anti-abortion movement — and Alabama and Tennessee are both calling special legislative sessions to redraw congressional maps and dilute Black voter representation, following the Supreme Court's recent green light to do exactly that. A summer water crisis is also taking shape across Texas, New Mexico, Colorado, Utah, Wyoming, and Nevada thanks to dangerously low snowpack, with Corpus Christi already under restrictions — largely because the petrochemical companies consuming most of the local water supply are still very much open for business. On a lighter note, a new JAMA Psychiatry study identified three distinct ADHD subtypes using brain scans from over 1,100 children, including a third type defined by emotional dysregulation that activates an entirely different part of the brain, which could meaningfully change how doctors diagnose and treat patients. GameStop's CEO is attempting a $56 billion hostile takeover of eBay, and finally, The Devil Wears Prada 2 opened to $77M domestically and $156M internationally in its debut weekend, driven overwhelmingly by women, and reportedly achieved profitability in roughly 48 hours. Resources/Articles mentioned: NBC News: Spirit Airlines collapse strands travelers: What to know about refunds, rebooking and fares FOX Business: National average gas price reaches $4.45 before summer driving season Politico: Trump tells Congress the Iran war has ‘terminated' as legal deadline hits Axios: Trump says new strikes possible if Iran "misbehaves" AP News: Trump says the US will 'guide' stranded ships from the Strait of Hormuz, starting on Monday Newsweek: Donald Trump says US will take over Cuba ‘almost immediately' WIRED: This Summer, the American Water Crisis Becomes Real Axios: Appeals court limits abortion pill access NBC News: Alabama and Tennessee set special sessions to consider new congressional maps after Supreme Court ruling WaPo: Brain scans reveal 3 ADHD subtypes, including a more extreme form WSJ: GameStop Offers to Buy eBay for $56 Billion AP News: ‘The Devil Wears Prada' struts to first place with $77 million debut Subscribe to the Betches News Room and join the Morning Announcements group chat. Go to: betchesnews.substack.com Morning Announcements is produced by Sami Sage and edited by Grace Hernandez-Johnson Learn more about your ad choices. Visit megaphone.fm/adchoices

Psychiatrists are clashing over antidepressant withdrawal: clinic data shows up to 50% of long-term SSRI/SRI users face severe symptoms, while a major 2025 JAMA Psychiatry meta-analysis claims they're usually mild and brief. We break down both sides, expose the massive limitations in the studies, and reveal what this means for millions on these drugs.

Episode 220: Approach of Insomnia in Adults     ARREAZA: Today we are going to talk about how to approach sleep issues in adults — from the initial assessment all the way through treatment. And I think what is going to surprise a lot of our listeners is the changes in management in recent years, especially what is recommended as first-line therapy. So, let's jump right in. MOIRA: Sleep is one of those topics that touches every specialty, but Primary Care in particular, so I'm excited to dig into this. ARREAZA: Let's start with the big picture–statistics. How common are sleep problems in adults? MOIRA: Incredibly common. Chronic insomnia affects roughly 10% of the general population, and that number has only grown in recent years . During the COVID-19 pandemic, for instance, prevalence rates of insomnia symptoms were reported globally at 20 to 45% (wow). And, importantly, those sleep problems did not simply resolve once infection rates dropped, insomnia symptoms and fatigue have continued even as mood improves in people recovering from COVID-19 infection.  ARREAZA: Incredible that we are in 2026 and still talking about COVID-19. And we clinicians need to understand that insomnia isn't just an annoyance. It has long-term consequences. Also, financially, insomnia causes direct and indirect costs of up to $100 billion each year. MOIRA: Exactly. Insomnia is both a risk factor for, and a symptom of, several psychiatric disorders, and it is a predictor of death by suicide, making it an important target for intervention. It's highly comorbid with medical and psychiatric disorders and is associated with significantly increased healthcare utilization and costs. People with insomnia also perform more poorly on complex cognitive tasks. So, we're talking about a condition that affects cognition, mental health, physical health, and quality of life. ARREAZA: And yet, it still gets overlooked in many clinical encounters. Let's be honest, dealing with insomnia is not easy on patients… and doctors! MOIRA: That's the paradox. Primary care practitioners are often poorly informed about sleep disorders, which remain underdiagnosed and sub-optimally managed. In one Italian epidemiological survey, insomnia was reported by 64% of over 3,000 patients interviewed under general practitioners, with 20% reporting both nighttime and daytime symptoms. So, the patients are there, we're just not always asking the right questions or knowing what to do when they tell us about their sleep. ARREAZA: Great. Let's talk about assessment. In my experience, we need a full encounter to address sleeping issues. Patients tend to mention insomnia as you start walking out of the room. Let's say a patient tells us, "Doctor, I can't sleep," how de we approach this? MOIRA: The first step is a comprehensive sleep and health history. Clinical assessment should describe the sleep disturbance and elicit etiological and exacerbating factors. You want to understand the nature of the complaint; is it difficulty to fall asleep, difficulty staying asleep, early morning awakening, or some combination? How long has it been going on? What's the impact on daytime functioning? ARREAZA: That's why I think it should be addressed in a full encounter, if possible, because understanding the full extent of the problem requires time. We need to think about contributing factors too. MOIRA: Absolutely. Factors such as medications, medical disorders, and psychiatric disorders can all increase the risk for insomnia. You need to screen for comorbid conditions, depression, anxiety, PTSD, and chronic pain. Insomnia is actually both a risk factor for and a symptom of several psychiatric disorders. You also want to rule out other primary sleep disorders. Comorbid insomnia and sleep apnea, for example, is highly prevalent and debilitating. If someone has both insomnia and obstructive sleep apnea, treating only one without addressing the other may lead to suboptimal outcomes. ARREAZA: Now that you mention comorbid conditions, let's mention nocturia. I feel like it's very common with my older patients. MOIRA: Great point. Nocturia (waking from sleep at night to void) and chronic insomnia frequently co-exist in older adults, contributing synergistically to sleep disturbance. Treatments typically target either nocturia or insomnia rather than simultaneously addressing the shared mechanisms for these disorders. There's emerging work on integrated cognitive-behavioral treatment programs that address both conditions simultaneously, which is a promising direction. But at minimum, you should be asking about it, because if nocturia is driving the awakenings, you need to address that as part of the treatment plan. _____________________ References: Baglioni, C., Altena, E., Bjorvatn, B., Blom, K., Bothelius, K., Devoto, A., … & Riemann, D. (2019). The European Academy for Cognitive Behavioural Therapy for Insomnia: An initiative of the European Insomnia Network to promote implementation and dissemination of treatment. Journal of Sleep Research, 29(2). https://doi.org/10.1111/jsr.12967 Becker, P. (2022). Overview of sleep management during COVID-19. Sleep Medicine, 91, 211-218. https://doi.org/10.1016/j.sleep.2021.04.024 Bramoweth, A., Germain, A., Youk, A., Rodriguez, K., & Chinman, M. (2018). A hybrid type I trial to increase Veterans' access to insomnia care: study protocol for a randomized controlled trial. Trials, 19(1). https://doi.org/10.1186/s13063-017-2437-y Brewster, G., Riegel, B., & Gehrman, P. (2018). Insomnia in the Older Adult. Sleep Medicine Clinics, 13(1), 13-19. https://doi.org/10.1016/j.jsmc.2017.09.002 Conroy, D. and Ebben, M. (2015). Referral Practices for Cognitive Behavioral Therapy for Insomnia: A Survey Study. Behavioural Neurology, 2015, 1-4. https://doi.org/10.1155/2015/819402 Dzierzewski, J., Griffin, S., Ravyts, S., & Rybarczyk, B. (2018). Psychological Interventions for Late-Life Insomnia: Current and Emerging Science. Current Sleep Medicine Reports, 4(4), 268-277. https://doi.org/10.1007/s40675-018-0129-0 Fung, C., Huang, A., Markland, A., Schembri, M., Martin, J., Bliwise, D., … & Vaughan, C. (2024). A multisite feasibility study of integrated cognitive‐behavioral treatment for co‐existing nocturia and chronic insomnia. Journal of the American Geriatrics Society, 73(2), 558-565. https://doi.org/10.1111/jgs.19214 Gardner, D., Turner, J., Magalhaes, S., Rajda, M., & Murphy, A. (2024). Patient Self-Guided Interventions to Reduce Sedative Use and Improve Sleep. Jama Psychiatry, 81(12), 1187. https://doi.org/10.1001/jamapsychiatry.2024.2731 Garland, S., Vargas, I., Grandner, M., & Perlis, M. (2018). Treating insomnia in patients with comorbid psychiatric disorders: A focused review. Canadian Psychology/Psychologie Canadienne, 59(2), 176-186. https://doi.org/10.1037/cap0000141 Germain, A., Wolfson, M., Brock, M., O'Reilly, B., Hearn, H., Knowles, S., … & Wallace, M. (2023). Digital CBTI hubs as a treatment augmentation strategy in military clinics: study protocol for a pragmatic randomized clinical trial. Trials, 24(1). https://doi.org/10.1186/s13063-023-07686-2 Theme song, Works All The Time by Dominik Schwarzer, YouTube ID: CUBDNERZU8HXUHBS, purchased from https://www.premiumbeat.com/. Even without trying, every night you go to bed a little wiser. Thanks for listening to Rio Bravo qWeek Podcast. We want to hear from you, send us an email at RioBravoqWeek@clinicasierravista.org, or visit our website riobravofmrp.org/qweek. See you next week!

Nesta quarta-feira, analisamos marcos na saúde pública e na validação científica da tecnologia, começando pelo Dia Mundial da Doença de Chagas, que destaca o papel central das mulheres na eliminação desta patologia e na interrupção da transmissão congênita. Detalhamos um estudo longitudinal do JAMA Psychiatry sobre o impacto da idade no diagnóstico de TDAH e como intervenções precoces influenciam a trajetória escolar e reduzem comorbidades. Por fim, abordamos o lançamento do periódico NEJM AI na plataforma Ovid, um novo repositório com padrão ouro de revisão por pares dedicado a validar a inteligência artificial na prática clínica.Afya News. Informação médica confiável e atualizada no seu tempo.Fontes do episódio aqui:⁠https://portal.afya.com.br/podcasts/afya-news/15-04-2026

Die meisten Ratgeber beruhen auf Stress-Forschung aus den 90ern – und wurden für 30-Jährige geschrieben. Kein Wunder, dass die alte Cortisol-Formel ab 40 nicht mehr zu funktionieren scheint.In dieser Folge erfährst Du, wie chronischer Stress Dein Hormonsystem ab 40 aus dem Takt bringt, warum Östrogen und Testosteron als natürliche Stresspuffer schwächer werden – und warum die gleiche Belastung Dich mit 45 messbar härter trifft als mit 30.Dazu bekommst Du fünf evidenzbasierte Werkzeuge, die Du noch diese Woche umsetzen kannst. Eins davon kostet Dich fünf Minuten am Tag. Eins brauchst Du nur, wenn Du in der Mittagspause ohnehin essen willst. Und eins ist das am besten dokumentierte Anti-Stress-Werkzeug der letzten zehn Jahre – obwohl es fast nie in Stress-Ratgebern auftaucht.Diese Folge ist für Dich, wenn Du wissen willst, was sich an Deinem Körper ab 40 wirklich verändert – und was konkret dagegen hilft.____________*WERBUNG: Infos zum Werbepartner dieser Folge und allen weiteren Werbepartnern findest Du hier.____________

Interview with Hemant Bhargav, MD, PhD, author of Yoga for Opioid Withdrawal and Autonomic Regulation: A Randomized Clinical Trial. Hosted by John Torous, MD. Related Content: Yoga for Opioid Withdrawal and Autonomic Regulation

In this episode, Dr. Puder sits down with Franciska de Beer, MSc, first author of landmark HAMLETT-OPHELIA Consortium papers in JAMA Psychiatry, World Psychiatry, and Psychological Medicine. They dive deep into the psychiatrist effect in first-episode psychosis, revealing that individual psychiatrists explain approximately 10% of variance in positive symptom improvement and daily functioning, even after controlling for medication dose. The conversation explores groundbreaking HAMLETT findings on early antipsychotic tapering versus maintenance, dopamine supersensitivity after high-affinity D2 blockers, sex differences in treatment outcomes and clozapine levels during menopause, and why shared decision-making and reflective functioning matter more than ever in psychosis care.   By listening to this episode, you can earn 1.25 Psychiatry CME Credits. Link to blog Link to YouTube video

The Psych Review is back with the first episode of 2026 and the first episode of Season 9! The crew is lead by Greg through a deep dive into potential side effects that can occur in relation to stimulant use. We discuss changes in ADHD assessment and management over the years, and potential consequences related to the increasing use of stimulant medications (including psychosis).The reference for this episode is:Greg: Salazar de Pablo, Gonzalo et al. Occurence of Psychosis and Bipolar Disorder in Individuals with Attention-Deficit/Hyperactivity Disorder Treatment with Stimulants - a Systematic Review and Meta-Analysis. JAMA Psychiatry. 2025 ;82(11):1103-1112.The Psych Review was brought to you by Call to Mind, a telepsychiatry service that you can learn more about at www.calltomind.com.au. The original music in our podcast was provided by the very talented John Badgery, and our logo was designed by the creative genius of Naz.

Interview with Balázs Szigeti, PhD, author of Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions: A Systematic Review and Meta-Analysis. Hosted by John Torous, MD. Related Content: Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions

Interview with Christian S. Hendershot, PhD, and Klara R. Klein, MD, PhD, authors of Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial. Hosted by John Torous, MD. Related Content: Once-Weekly Semaglutide in Adults With Alcohol Use Disorder Semaglutide Shows Promise in Reducing Alcohol Cravings

PsychopharmaPearls is NEI's focused podcast series highlighting the clinical insights that can sharpen your prescribing decisions. In this episode, Dr. Andy Cutler talks with Dr. Lisa Harding about how to choose between IV ketamine and intranasal esketamine for patients with difficult-to-treat depression. They unpack the differences that truly matter in practice—from patient selection and monitoring to access, cost, and common missteps. Tune in for practical pearls you can immediately apply to select the right treatment for the right patient.  Lisa Harding, MD is a board-certified psychiatrist and nationally recognized depression specialist with deep expertise in interventional psychiatry. She has performed more than 4,000 procedures, including electroconvulsive therapy (ECT), intravenous ketamine, intranasal esketamine, and transcranial magnetic stimulation (TMS). Dr. Harding is known for her thoughtful approach to complex, treatment-resistant depression, integrating advanced somatic therapies, psychopharmacology, and psychotherapy. She serves as an Assistant Clinical Professor of Psychiatry at Yale University in New Haven, Connecticut.  Andrew J. Cutler, MD is a leading psychiatrist, psychopharmacology expert, and clinical researcher with decades of experience in CNS drug development. As Chief Medical Officer of Neuroscience Education Institute and EMA Wellness, he brings frontline clinical insight together with deep knowledge of the evidence base. Dr. Cutler is widely recognized for translating research into practical guidance for everyday practice and serves as a Clinical Associate Professor of Psychiatry at SUNY Upstate Medical University in Syracuse, New York.  Resources  Sanacora G et al. A Consensus Statement on the Use of Ketamine in the Treatment of Mood Disorders. JAMA Psychiatry 2017;74(4):399-405. doi:10.1001/jamapsychiatry.2017.0080  McIntyre RS et al. Synthesizing the Evidence for Ketamine and Esketamine in Treatment-Resistant Depression: An International Expert Opinion on the Available Evidence and Implementation. Am J Psychiatry 2021;178(5):383-399. doi:10.1176/appi.ajp.2020.20081251    Save $100 on registration for 2026 NEI Spring Congress with code NEIPOD26  Register today at nei.global/spring    Never miss an episode!

Psychedelics are having a cultural moment. Research is promising. Stories of healing are everywhere. But here's the truth: these experiences aren't magic cures. And they aren't right for every nervous system at every time.   In this episode, Elisabeth Kristof and Jennifer Wallace slow the conversation down. Instead of asking, "Do psychedelics heal trauma?" They explore a more grounded question: What becomes possible when psychedelic or peak somatic experiences are approached through the lens of nervous system safety, preparation, and integration?   If you've been curious about psychedelics, already had experiences, or feel unsure whether they're right for you, this episode offers nuance, research, and deep nervous system perspective. Because post-traumatic growth isn't about becoming someone new. It's about becoming more available to the life that's already waiting for you.   Topic Covered Why psychedelics may reorganize meaning, not just reduce symptoms How trauma fragments narrative and how safety allows integration The science of psychological flexibility and why it predicts long-term outcomes What "somatic journeying" is and why it can feel disorienting The importance of preparation, titration, and facilitator trust Why intensity does not equal healing Psychedelics vs antidepressants in research on connectedness Default Mode Network (DMN), identity rigidity, and belief updating Why creativity often emerges when survival softens The risks of over-reliance and "chasing the medicine" Why discernment and self-trust matter more than hype   Chapters  00:00 – Psychedelics Aren't Magic Cures
 03:00 – Meaning-Making & Narrative Reorganization
 08:58 – Psychological Flexibility & Emotional Capacity
 17:00 – Preparation, Somatic Journeying & Integration
 23:29 – Connectedness & Relational Repair
 34:33 – Identity, Neuro Tags & the Default Mode Network
 41:03 – Creativity as a Byproduct of Safety
 48:14 – Discernment, Industry Hype & Self-Trust   Calls to Action: Neurosomatic Intelligence is now enrolling : https://neurosomaticintelligence.com/nsi-certification Sacred Synapse: an educational YouTube channel founded by Jennifer Wallace that explores nervous system regulation, applied neuroscience, consciousness, and psychedelic preparation and integration through Neurosomatic Intelligence.    Wayfinder Journal: Track nervous system patterns and support preparation and integration through Neurosomatic Intelligence.   FREE 1 Year Supply of Vitamin D + 5 Travel Packs from Athletic Greens when you use my exclusive offer: https://www.drinkag1.com/rewired  Learn to work with Boundaries at the level of the body and nervous system at https://www.boundaryrewire.com Get a two-week free trial of neurosomatic training at https://rewiretrial.com Sources:    Amada, N., et al. "The Transformative Potential of Psychedelic Experiences: A Qualitative Analysis of Meaning-Making and Narrative Reorganization." Journal of Consciousness Studies, vol. 27, no. 7–8, 2020, pp. 122–150.   Carhart-Harris, Robin L., et al. "Neural Correlates of the Psychedelic State as Determined by fMRI Studies with Psilocybin." Proceedings of the National Academy of Sciences, vol. 109, no. 6, 2012, pp. 2138–2143.   Carhart-Harris, Robin L., et al. "The Entropic Brain: A Theory of Conscious States Informed by Neuroimaging Research with Psychedelic Drugs." Frontiers in Human Neuroscience, vol. 8, 2014, article 20.   Carhart-Harris, Robin L., et al. "Psilocybin with Psychological Support for Treatment-Resistant Depression: Six-Month Follow-Up." Psychopharmacology, vol. 235, no. 2, 2018, pp. 399–408.   Davis, Alan K., Roland R. Griffiths, and Frederick S. Barrett. "Psychological Flexibility Mediates the Relations between Acute Psychedelic Effects and Subjective Decreases in Depression and Anxiety." Journal of Contextual Behavioral Science, vol. 15, 2020, pp. 39–45.   Davis, Alan K., et al. "Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder: A Randomized Clinical Trial." JAMA Psychiatry, vol. 78, no. 5, 2021, pp. 481–489.   Erritzoe, David, et al. "Effects of Psilocybin Therapy versus Escitalopram on Depression and Emotional Connectedness in Major Depressive Disorder." The New England Journal of Medicine, vol. 384, 2021, pp. 1402–1411.   Griffiths, Roland R., et al. "Psilocybin Produces Substantial and Sustained Decreases in Depression and Anxiety in Patients with Life-Threatening Cancer: A Randomized Double-Blind Trial." Journal of Psychopharmacology, vol. 30, no. 12, 2016, pp. 1181–1197.   MacLean, Katherine A., Matthew W. Johnson, and Roland R. Griffiths. "Mystical Experiences Occasioned by the Hallucinogen Psilocybin Lead to Increases in the Personality Domain of Openness." Journal of Psychopharmacology, vol. 25, no. 11, 2011, pp. 1453–1461.   Watts, Rosalind, et al. "Patients' Accounts of Increased 'Connectedness' and 'Acceptance' after Psilocybin for Treatment-Resistant Depression." Journal of Humanistic Psychology, vol. 57, no. 5, 2017, pp. 520–564.   Weiss, B., et al. "Associations between Naturalistic Psychedelic Use, Psychological Insight, and Changes in Social Connectedness and Personality." Frontiers in Psychology, vol. 12, 2021, article 667987. Disclaimer: Trauma Rewired podcast is intended to educate and inform but does not constitute medical, psychological or other professional advice or services. Always consult a qualified medical professional about your specific circumstances before making any decisions based on what you hear. We share our experiences, explore trauma, physical reactions, mental health and disease. If you become distressed by our content, please stop listening and seek professional support when needed. Do not continue to listen if the conversations are having a negative impact on your health and well-being. If you or someone you know is struggling with their mental health, or in mental health crisis and you are in the United States you can 988 Suicide and Crisis Lifeline.   If someone's life is in danger, immediately call 911.   We do our best to stay current in research, but older episodes are always available. We don't warrant or guarantee that this podcast contains complete, accurate or up-to-date information. It's very important to talk to a medical professional about your individual needs, as we aren't responsible for any actions you take based on the information you hear in this podcast.   We invite guests onto the podcast. Please note that we don't verify the accuracy of their statements. Our organization does not endorse third-party content and the views of our guests do not necessarily represent the views of our organization. We talk about general neuro-science and nervous system health, but you are unique. These are conversations for a wide audience. They are general recommendations and you are always advised to seek personal care for your unique outputs, trauma and needs.   We are not doctors or licensed medical professionals. We are certified neuro-somatic practitioners and nervous system health/embodiment coaches. We are not your doctor or medical professional and do not know you and your unique nervous system. This podcast is not a replacement for working with a professional. The BrainBased.com site and RewireTrial.com is a membership site for general nervous system health, somatic processing and stress processing. It is not a substitute for medical care or the appropriate solution for anyone in a mental health crisis.   Any examples mentioned in this podcast are for illustration purposes only. If they are based on real events, names have been changed to protect the identities of those involved.   We've done our best to ensure our podcast respects the intellectual property rights of others, however if you have an issue with our content, please let us know by emailing us at traumarewired@gmail.com. All rights in our content are reserved.

Interview with Christian A. Webb, PhD, author of Predicting Adolescent Response to School-Based Mindfulness: A Secondary Analysis of the MYRIAD Trial. Hosted by John Torous, MD. Related Content: Predicting Adolescent Response to School-Based Mindfulness

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-470 Overview: Social media use is nearly ubiquitous among adolescents, raising concern about its role in rising rates of depression, anxiety, insomnia, and suicidality. Although prior evidence has been mixed, emerging studies offer new insights on the relationship between social media use and adolescent mental health. Join us as we review current literature and discuss potential strategies to mitigate negative impacts and improve outcomes. Episode resource links: Calvert E, Cipriani M, Dwyer B, et al. Social Media Detox and Youth Mental Health. JAMA Netw Open. 2025;8(11):e2545245. doi:10.1001/jamanetworkopen.2025.45245 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2840489   Clayborne ZM, Capaldi CA, Mehra VM. Associations between digital media use behaviours, screen time and positive mental health in youth: results from the 2019 Canadian Health Survey on Children and Youth. BMC Public Health. 2025;25(1):2303. Published 2025 Jul 3. doi:10.1186/s12889-025-22874-2 Grøntved A, Singhammer J, Froberg K, et al. A prospective study of screen time in adolescence and depression symptoms in young adulthood. Prev Med. 2015;81:108-113. doi:10.1016/j.ypmed.2015.08.009 Nagata JM, Memon Z, Talebloo J, et al. Prevalence and Patterns of Social Media Use in Early Adolescents. Acad Pediatr. 2025;25(4):102784. doi:10.1016/j.acap.2025.102784 Oberle E, Ji XR, Kerai S, Guhn M, Schonert-Reichl KA, Gadermann AM. Screen time and extracurricular activities as risk and protective factors for mental health in adolescence: A population-level study. Prev Med. 2020;141:106291. doi:10.1016/j.ypmed.2020.106291 Pieh C, Humer E, Hoenigl A, et al. Smartphone screen time reduction improves mental health: a randomized controlled trial. BMC Med. 2025;23(1):107. Published 2025 Feb 21. doi:10.1186/s12916-025-03944-z Riehm KE, Feder KA, Tormohlen KN, et al. Associations Between Time Spent Using Social Media and Internalizing and Externalizing Problems Among US Youth. JAMA Psychiatry. 2019;76(12):1266–1273. doi:10.1001/jamapsychiatry.2019.2325 Varona MN, Muela A, Machimbarrena JM. Problematic use or addiction? A scoping review on conceptual and operational definitions of negative social networking sites use in adolescents. Addict Behav. 2022;134:107400. doi:10.1016/j.addbeh.2022.107400 Woolf SH. The Youth Mental Health Crisis in the United States: Epidemiology, Contributors, and Potential Solutions. Pediatrics. 2025;156(5):e2025070849. doi:10.1542/peds.2025-070849 Xiang AH, Martinez MP, Chow T, et al. Depression and Anxiety Among US Children and Young Adults. JAMA Netw Open. 2024;7(10):e2436906. doi:10.1001/jamanetworkopen.2024.36906 BBC: Australia has banned social media for kids under 16. How will it work? https://www.bbc.com/news/articles/cwyp9d3ddqyo Guest: Susan Feeney, DNP, FNP-BC, NP-C   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-470 Overview: Social media use is nearly ubiquitous among adolescents, raising concern about its role in rising rates of depression, anxiety, insomnia, and suicidality. Although prior evidence has been mixed, emerging studies offer new insights on the relationship between social media use and adolescent mental health. Join us as we review current literature and discuss potential strategies to mitigate negative impacts and improve outcomes. Episode resource links: Calvert E, Cipriani M, Dwyer B, et al. Social Media Detox and Youth Mental Health. JAMA Netw Open. 2025;8(11):e2545245. doi:10.1001/jamanetworkopen.2025.45245 https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2840489   Clayborne ZM, Capaldi CA, Mehra VM. Associations between digital media use behaviours, screen time and positive mental health in youth: results from the 2019 Canadian Health Survey on Children and Youth. BMC Public Health. 2025;25(1):2303. Published 2025 Jul 3. doi:10.1186/s12889-025-22874-2 Grøntved A, Singhammer J, Froberg K, et al. A prospective study of screen time in adolescence and depression symptoms in young adulthood. Prev Med. 2015;81:108-113. doi:10.1016/j.ypmed.2015.08.009 Nagata JM, Memon Z, Talebloo J, et al. Prevalence and Patterns of Social Media Use in Early Adolescents. Acad Pediatr. 2025;25(4):102784. doi:10.1016/j.acap.2025.102784 Oberle E, Ji XR, Kerai S, Guhn M, Schonert-Reichl KA, Gadermann AM. Screen time and extracurricular activities as risk and protective factors for mental health in adolescence: A population-level study. Prev Med. 2020;141:106291. doi:10.1016/j.ypmed.2020.106291 Pieh C, Humer E, Hoenigl A, et al. Smartphone screen time reduction improves mental health: a randomized controlled trial. BMC Med. 2025;23(1):107. Published 2025 Feb 21. doi:10.1186/s12916-025-03944-z Riehm KE, Feder KA, Tormohlen KN, et al. Associations Between Time Spent Using Social Media and Internalizing and Externalizing Problems Among US Youth. JAMA Psychiatry. 2019;76(12):1266–1273. doi:10.1001/jamapsychiatry.2019.2325 Varona MN, Muela A, Machimbarrena JM. Problematic use or addiction? A scoping review on conceptual and operational definitions of negative social networking sites use in adolescents. Addict Behav. 2022;134:107400. doi:10.1016/j.addbeh.2022.107400 Woolf SH. The Youth Mental Health Crisis in the United States: Epidemiology, Contributors, and Potential Solutions. Pediatrics. 2025;156(5):e2025070849. doi:10.1542/peds.2025-070849 Xiang AH, Martinez MP, Chow T, et al. Depression and Anxiety Among US Children and Young Adults. JAMA Netw Open. 2024;7(10):e2436906. doi:10.1001/jamanetworkopen.2024.36906 BBC: Australia has banned social media for kids under 16. How will it work? https://www.bbc.com/news/articles/cwyp9d3ddqyo Guest: Susan Feeney, DNP, FNP-BC, NP-C   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com  The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.

We return to the podcast circuit in 2026 to examine Scott Galloway: NYU professor, prolific podcaster, and, more recently, part-time life coach for struggling young men.Joining him on an episode of Modern Wisdom with Chris Williamson, we are invited into one of the few remaining forbidden conversational spaces: men, masculinity, and men's problems. You may have been misled by the relentless popularity of Joe Rogan, Modern Wisdom, The Tucker Carlson Show, Triggernometry, The Diary of a CEO, Huberman Lab, and several dozen adjacent properties into thinking these topics are already discussed at length on a near-weekly basis. Alas, this turns out to be a dangerous illusion.In reality, even mentioning men's issues requires an extended ritual acknowledgement of women, failure to perform which risks immediate cancellation. Braving these cultural headwinds, we wade into manly dialogue about masculinity, sex differences, and male malaise. Along the way, we ponder the intricacies of culture war evolutionary psychology, anthropological wars over Man the Hunter, optimised dosages for manly whingeing, and whether making boys learn French verb conjugations qualifies as a human rights abuse.So get your notebooks ready for some important notes from two of the most masculine men in the modern male podcasting space. Men...LinksModern Wisdom: The War On Men Isn't Helping Anyone - Scott GallowayThe Diary of a CEO: Scott Galloway: We're Raising The Most Unhappy Generation In History! Hard Work Doesn't Build WealthAcademic papers ReferencedChanges in gender-based hiring bias (large meta-analysis): Schaerer, M., Du Plessis, C., Nguyen, M. H. B., Van Aert, R. C., Tiokhin, L., Lakens, D., … Gender Audits Forecasting Collaboration. (2023). On the trajectory of discrimination: A meta-analysis and forecasting survey capturing 44 years of field experiments on gender and hiring decisions. Organizational Behavior and Human Decision Processes, 179, 104280.Epidemiology of alcohol use disorder by marital status (US, NESARC-III): Grant, B. F., Goldstein, R. B., Saha, T. D., et al. (2015). Epidemiology of DSM-5 Alcohol Use Disorder: Results from the National Epidemiologic Survey on Alcohol and Related Conditions III. JAMA Psychiatry, 72(8), 757–766.Protective effects of marriage on life expectancy (US Medicare sample): Jia, H., & Lubetkin, E. I. (2020). Life expectancy and active life expectancy by marital status among older US adults: Results from the US Medicare Health Outcome Survey (HOS). SSM – Population Health, 12, 100642.Widowhood and well-being (contrary to claims of increased happiness): Adena, M., Hamermesh, D., Myck, M., & Oczkowska, M. (2023). Home alone: Widows' well-being and time. Journal of Happiness Studies, 24(2), 813–838.Meta-analysis of the widowhood effect on mortality (men and women): Shor, E., Roelfs, D. J., Curreli, M., Clemow, L., Burg, M. M., & Schwartz, J. E. (2012). Widowhood and mortality: A meta-analysis and meta-regression. Demography, 49(2), 575–606.Marriage and life satisfaction across the life course (multi-country): Mikucka, M. (2016). The life satisfaction advantage of being married and gender specialization....

Interview with Amy N. Cohen, PhD, and Matthew Chinman, PhD, authors of Tailored Weight Loss Programs for Adults With Serious Mental Illness: A Randomized Clinical Trial. Hosted by John Torous, MD. Related Content: Tailored Weight Loss Programs for Adults With Serious Mental Illness

Join Drs. Andy Cutler and Roger McIntyre as they discuss the most significant advancements in psychopharmacology over the past year. Their conversation highlights groundbreaking developments and innovations in the field of psychiatry.   Roger McIntyre, MD, FRCPC, is a globally recognized psychiatrist and psychopharmacologist who holds pivotal roles in academia, research, and leadership. His research primarily focuses on the phenomenology, neurobiology, and development of novel therapeutics for mood disorders. Dr. McIntyre is currently a Professor of Psychiatry and Pharmacology at the University of Toronto.   Andrew J. Cutler, MD, is a distinguished psychiatrist and researcher with extensive experience in clinical trials and psychopharmacology. He currently serves as the Chief Medical Officer of Neuroscience Education Institute and holds the position of Clinical Associate Professor of Psychiatry at SUNY Upstate Medical University in Syracuse, New York.  Resources  Thanarajah ES et al. Soft drink consumption and depression mediated by gut microbiome alterations. JAMA Psychiatry 2025;82(11):1095–1102. doi:10.1001/jamapsychiatry.2025.2579  Durgam S et al. Lumateperone as adjunctive therapy in patients with major depressive disorder: results from a randomized, double-blind, phase 3 trial. J Clin Psychiatry 2025;86(4):25m15848. doi: 10.4088/JCP.25m15848  Hendershot CS et al. Once-weekly semaglutide in adults with alcohol use disorder: a randomized clinical trial. JAMA Psychiatry 2025;82(4):395–405. doi: 10.1001/jamapsychiatry.2024.4789  Aron L et al. Lithium deficiency and the onset of Alzheimer's disease. Nature 2025;645:712–21. doi: 10.1038/s41586-025-09335-x  Never miss an episode!

In episode 70 we discuss an article about prescription stimulant misuse. Han B, Jones CM, Volkow ND, et al.Prescription Stimulant Use, Misuse, and Use Disorder Among US Adults Aged 18 to 64 Years. JAMA Psychiatry. 2025;82(6):572–581. We also discuss the ASAM toolkit for addressing problems at the pharmacy with buprenorphine, and results of the 2024 NSDUH study. ASAM:Addressing Issues at the Pharmacy with Buprenorphine Prescriptions Link to report pharmacy issues STATNews:Tobacco use, binge drinking decrease as Americans consume more marijuana, survey finds --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go tothis link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visitMI CARES. CME:https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music:composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer:Dr. Patrick Beeman A podcast fromArs Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook:@AddictionMedJC Facebook Group:Addiction Medicine Journal Club Instagram:@AddictionMedJC Threads:@AddictionMedJC YouTube:addictionmedicinejournalclub Twitter/X:@AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices

In our final episode of 2025 The Psych Review team are lead by Milla down the twisting rabbit hole that is inflammation in neuropsychiatry. The team discuss recent evidence around proposed inflammatory mechanisms that might underpin the psychiatric conditions we discuss every episode.The references for this episode are:Milla: Upthegrove, Rachel et al. Current Position and Future Direction of Inflammation in Neuropsychiatric Disorders, A Review. JAMA Psychiatry, volume 82, number 10, October 2025.The Psych Review was brought to you by Call to Mind, a telepsychiatry service that you can learn more about at www.calltomind.com.au. The original music in our podcast was provided by the very talented John Badgery, and our logo was designed by the creative genius of Naz.

La dépression légère à modérée ne nécessite pas toujours un traitement médicamenteux. De nombreuses études montrent que certains remèdes naturels, bien choisis, peuvent agir efficacement sur l'humeur, l'énergie et la motivation. Sans remplacer un suivi médical, ces solutions offrent une alternative douce et scientifiquement validée.Le plus célèbre d'entre eux est sans doute le millepertuis (Hypericum perforatum). Cette plante agit sur la sérotonine, la dopamine et la noradrénaline — trois neurotransmetteurs essentiels à la régulation de l'humeur. Plusieurs méta-analyses ont montré que, pour les dépressions légères à modérées, le millepertuis est aussi efficace que certains antidépresseurs chimiques, tout en provoquant moins d'effets secondaires. Mais prudence : il interagit avec de nombreux médicaments (pilule contraceptive, anticoagulants, etc.) et doit être pris sous supervision médicale.Autre allié puissant : l'exercice physique régulier. Selon une étude publiée dans JAMA Psychiatry, 30 minutes d'activité physique cinq fois par semaine réduisent les symptômes dépressifs presque autant qu'un traitement médicamenteux. Le sport stimule la sécrétion d'endorphines, de dopamine et de BDNF, une protéine qui favorise la régénération des neurones. En clair, bouger modifie la chimie du cerveau de manière durable et positive.L'alimentation joue également un rôle clé. Les régimes riches en oméga-3 (présents dans le saumon, les sardines ou les graines de lin) sont associés à un risque plus faible de dépression. Ces acides gras participent au bon fonctionnement des membranes neuronales. De même, une carence en vitamine D, fréquente en hiver, est liée à une baisse de moral. Un apport suffisant — via le soleil, les œufs ou les suppléments — peut aider à rétablir l'équilibre.Parmi les autres pistes validées par la science : la méditation de pleine conscience, qui réduit les rechutes dépressives de près de 40 % selon une étude de l'Université d'Oxford, et la luminothérapie, particulièrement efficace contre la dépression saisonnière. S'exposer chaque matin à une lumière blanche intense pendant 30 minutes régule la mélatonine et stabilise l'humeur.Enfin, le sommeil reste un pilier souvent négligé : se coucher à heures régulières et éviter les écrans le soir améliore la production naturelle de sérotonine.En somme, les antidépresseurs naturels les plus efficaces — sport, lumière, plantes, alimentation, méditation — agissent tous sur un même levier : restaurer l'équilibre biologique du cerveau, sans effets secondaires lourds. Une preuve que la nature et nos habitudes peuvent, parfois, rivaliser avec la chimie. Hébergé par Acast. Visitez acast.com/privacy pour plus d'informations.

In episode 66 we discuss an article about smoking during substance use disorder recovery.    Parks MJ, Blanco C, Creamer MR, et al. Cigarette Smoking During Recovery From Substance Use Disorders. JAMA Psychiatry. Published online August 13, 2025.     We also discuss how the White House is pressuring the FDA to fast-track nicotine products and shenanigans regarding alcohol in the upcoming FDA dietary guidelines.    Reuters: US FDA to fast-track nicotine pouch reviews amid White House pressure  Vox: RFK Jr. and the White House buried a major study on alcohol and cancer. Here's what it shows.  Draft Report: Scientific Findings of the Alcohol Intake & Health Study for Public Comment  ---  This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.  CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/   ---  Original theme music: composed and performed by Benjamin Kennedy  Audio editing: Michael Bonanno  Executive producer: Dr. Patrick Beeman  A podcast from Ars Longa Media  ---  This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.     The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.  ---  Email: addictionmedicinejournalclub@gmail.com   Facebook: @AddictionMedJC  Facebook Group: Addiction Medicine Journal Club  Instagram: @AddictionMedJC   Threads: @AddictionMedJC  YouTube: addictionmedicinejournalclub   Twitter/X: @AddictionMedJC    ---  Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices

A new study is making headlines — not because kids are on screens too much, but because many can’t stop. Dr Justin Coulson unpacks fresh research linking addictive screen use (not screen time itself) with anxiety, depression, and suicidal thoughts in teens. Learn what “addiction” really means, why it’s not an official diagnosis, and how to protect your child without constant conflict. KEY POINTS The latest data from the Adolescent Brain Cognitive Development Study shows addictive patterns of screen use — not hours online — are tied to poorer mental health. “Addictive” use means kids feel distress when not online, use screens to regulate emotions, or can’t stop even when it causes problems. There’s no official “screen addiction” diagnosis, but the behaviour patterns are real — and concerning. Justin shares practical strategies using the Three E’s of Effective Discipline to reduce conflict and foster healthy habits. Real-life example: how the Coulson family handled screen boundaries with collaboration, not control. QUOTE OF THE EPISODE “Time on a device isn’t the problem. It’s when kids can’t stop that their mental health starts to suffer.” RESOURCES MENTIONED Adolescent Brain Cognitive Development (ABCD) Study, JAMA Psychiatry, June 2024 Screen "addiction" and mental Health - Technosapiens Tools: Freedom App, Forest App, Brick, Unplug Childhood Framework: The Three E’s of Effective Discipline (Explore, Explain, Empower) ACTION STEPS FOR PARENTS Have a calm conversation about how and why your child uses screens. Model mindful use — show your own limits and honesty about the struggle. Create structure, not punishment — consistent times, agreed limits. Watch for red flags like irritability, secrecy, or big emotions when screens are removed. Offer alternatives — list 10+ enjoyable non-screen activities your child can choose from. See omnystudio.com/listener for privacy information.

Interview with Declan M. McLoughlin, PhD, author of Serial Ketamine Infusions as Adjunctive Therapy to Inpatient Care for Depression: The KARMA-Dep 2 Randomized Clinical Trial. Hosted by John Torous, MD. Related Content: Serial Ketamine Infusions as Adjunctive Therapy to Inpatient Care for Depression

Thank you to everyone who tuned into my live video! Join me for my next live video in the app.Trigger Warnings: Trump Disbands CongressSources:Democracy Now!democracynow.org/2025/10/8/adel…“Scary Precedent”: GOP Blocks Rep.-Elect Adelita Grijalva from Taking Seat Amid Epstein Files FightRepresentative-elect Adelita Grijalva, who won a special election for a House seat in Arizona two weeks ago, has still not been sworn in to Congress. Republican Speaker of the House Mike Johnson is blaming the government shutdown for the delay, even though he previously expedited the swearing-in of multiple Republicans who won their special elections before election results were even in. It's more likely, say supporters, that Grijalva is being held up to prevent what she has pledged will be her first act in Congress: adding her name to and thus triggering a vote on California Congressmember Ro Khanna's bill for the public release of files related to the federal investigation of sex trafficker Jeffrey Epstein. “She needs to get sworn in today,” says Khanna, adding that every day Grijalva is not seated in the House “is breaking precedent and depriving people of who they voted for.” Grijalva says, “This is an incredibly scary precedent to set. If you don't agree with the politics of the speaker, then they can keep you out of your duly elected office.” Khanna and Grijalva also discuss the legacy of Grijalva's late father, the longtime Arizona Congressmember Raúl Grijalva; the Trump administration's crackdown on immigration; right-wing attacks on freedom of the press; and more.AP Newsapnews.com/article/house-…Speaker Johnson keeps the House away as he fights to end the government shutdownHouse members' absence during the government shutdown is creating a political dilemma for Republican Speaker Mike Johnson and is testing his leadership.Chicago Tribunechicagotribune.com/2025/10/10/mik…Speaker Mike Johnson keeps the House away as he fights to end ...Mike Johnson is the speaker of a House that is no longer in session.POLITICOpolitico.com/news/2025/10/0…Mike Johnson sticks to no-show shutdown strategy as ... - Politico“There is absolutely no reason for the House to be out of session,” GOP Rep. Kevin Kiley said. “It's embarrassing.'Democratic Erosion Consortiumdemocratic-erosion.org/2025/04/18/how…How to Erode a Democracy: Hungary's Illiberal Turn Under OrbánThis blog post examines how Viktor Orbán has used media control, legal manipulation, and populist nationalism to methodically destroy Hungary's democratic institutions and turn the nation into the first “illiberal democracy” in the EU.NPRnpr.org/2025/04/20/nx-…Hungary's Orban demonstrates how to dismantle democracy - NPRThe dismantling of Hungary's democracy is a point of fascination for political scientists around the world — including those advising the Trump administration.cnncnn.com/2020/03/30/eur…Hungarian parliament votes to let Viktor Orban rule by decree ... - CNNHungary's parliament has voted to allow Prime Minister Viktor Orban to rule by decree indefinitely, in order to combat the coronavirus pandemic, giving the populist leader extra powers to unilaterally…CNNcnn.com/2025/10/08/pol…Tempers flare between Democratic senators and Speaker Johnson over Grijalva's swearing in and shutdown strategyArizona's Democratic senators got into a hallway confrontation with Republican House Speaker Mike Johnson on Wednesday as the government shutdown's eighth day dragged on.RFKjr & Autism: I Wrote a Foreword Just for YouSourcesCounter/neutral positions from regulators and clinical bodies* European Medicines Agency (EMA), PRAC communications on paracetamol in pregnancy: EMA has stated available evidence does not establish a causal link; use remains appropriate when clinically indicated at the lowest effective dose. Overview page: https://www.ema.europa.eu/en/medicines/human/referrals/paracetamol* (If needed: EMA general paracetamol product information hub where PRAC updates are posted.)* American College of Obstetricians and Gynecologists (ACOG). ACOG Guidance: Acetaminophen use during pregnancy. ACOG states evidence of neurodevelopmental harms is inconsistent and methodologically limited; acetaminophen remains appropriate when indicated. Practice Advisory/FAQ landing: https://www.acog.org/womens-health/faqs/medication-safety-during-pregnancySystematic reviews/meta-analyses with nuanced conclusions* Alemany S et al. Prenatal and postnatal exposure to acetaminophen and ADHD and autism spectrum symptoms in childhood: meta-analysis/pooled observational evidence. European Journal of Epidemiology (2021). Publisher page (Springer): https://link.springer.com/article/10.1007/s10654-021-00757-3U.S. federal perspective* U.S. FDA Drug Safety (Acetaminophen use in pregnancy). FDA has not concluded causality with autism; advises using the lowest effective dose for the shortest duration. Consumer/Drug Safety hub: https://www.fda.gov/consumers/consumer-updates/acetaminophen-overdose-and-liver-injury-know-ingredients-your-medicine* For pregnancy-specific FDA language, see: https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/medication-use-during-pregnancy-and-lactationSupportive association signals (observational; not proof of causality, few supportive links exist)* Ji Y et al. Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder. JAMA Psychiatry (2019). Link: https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2753510Evidence on emotional and social pain blunting* Social pain/evaluative processing: Experimental psychology studies have reported that standard doses of acetaminophen can reduce the distress of social rejection and blunt affective evaluations, suggesting overlap between physical and social pain processing in the brain. These findings support the idea that acetaminophen influences affective components of pain perception, though effect sizes are modest and not uniformly replicated across all paradigms. pbs​* Risk of overgeneralization: While these lab findings are provocative, they do not establish acetaminophen as a mood treatment. Regulatory and clinical bodies do not recommend acetaminophen for depression, and evidence for sustained antidepressant benefit is lacking. pbs This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit johnnyprofaneknapp.substack.com/subscribe

Uma notícia que pode mudar a forma como pensamos o tratamento de um dos transtornos mais desafiadores da psiquiatria. A semaglutida, amplamente utilizada no manejo da obesidade, parece ter resultados promissores no tratamento do Transtorno por Uso de Álcool. No episódio 331 do PQU Podcast, fazemos uma revisão crítica de um estudo recente publicado na JAMA Psychiatry sobre o assunto. Apresentamos os dados e trazemos nossa visão crítica sobre o que realmente significam: é evidência com opinião. Convidamos você, psiquiatra em formação, para escutar o episódio completo na sua plataforma preferida. Não perca!

You requested; we delivered. Lots of Science Fictions listeners have asked us to take a look into Donald Trump and RFK, Jr.'s recent claims about Tylenol (that is, paracetamol or acetaminophen—all the same thing). Does it cause autism?It turns out there's more to this than you might've thought—regardless of all the recent hype, a lot of very reputable scientists take the idea seriously. But should they? In this emergency podcast, we go through all the relevant studies.The Science Fictions podcast is brought to you by Works in Progress magazine. In the ad this week we mentioned “The Death Rays that Guard Life”, an article from Issue 20 of the magazine about far-UVC light and how—with a lot more research—it might be the next big thing for reducing the spread of germs in hospitals and classrooms. Find that and many other articles and podcasts at worksinprogress.co.Show notes* The FDA's September 2025 announcement on Tylenol and autism* The UK's Department of Health and Social Care announcement the same day* “The phrase ‘no evidence' is a read flag for bad science communication”, by Scott Alexander* 2003 theoretical paper with speculation about paracetamol and neurodevelopmental disorders* 2013 sibling control study in the International Journal of Epidemiology* “Ecological” study in Environmental Health from 2013 about circumcision rates, paracetamol, and autism* 2015 Danish seven-year follow-up study* 2019 cord blood study in JAMA Psychiatry* 2021 “consensus statement” on paracetamol and neurodevelopment* 2025 Japanese sibling-control study* 2024 very large Swedish sibling-control study* Study that sparked the current debate: the “Navigation Guide” review from Environmental Health* Description of what “Navigation Guide” is* STAT News on the evidence for a paracetamol-autism link; and on the controversy about the Dean of the Harvard School of Public Health* White House statement defending the existence of the link* BMJ article summing up the controversyCreditsThe Science Fictions podcast is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit sciencefictionspod.substack.com/subscribe

REFERENCES 1. Miller RV. Tylenol autism lawsuit. Lawsuit Information Center. September 21, 2025. Accessed September 25, 2025. https://www.lawsuit-information-center.com/tylenol-autism-lawsuit.html 2. Gerstein AS, Niederhelman EF. Harvard's public health dean was paid $150,000 to testify Tylenol causes autism. The Harvard Crimson. September 24, 2025. Accessed September 25, 2025. https://www.thecrimson.com/article/2025/9/24/autism-dean-public-health/ 3. Poll: Most Americans encounter health misinformation, and most aren't sure whether it's true or false. News Release. KFF. August 22, 2023. Accessed September 26, 2025. https://www.kff.org/covid-19/poll-most-americans-encounter-health-misinformation-and-most-arent-sure-whether-its-true-or-false/ 4. Prada D, Ritz B, Bauer AZ, et al. Evaluation of the evidence on acetaminophen use and neurodevelopmental disorders using the Navigation Guide methodology. Environ Health. 2025 Aug 14;24(1):56. doi: 10.1186/s12940-025-01208-0. 5. Ahlqvist VH, Sjöqvist H, Dalman C, et al. Acetaminophen use during pregnancy and children's risk of autism, ADHD, and intellectual disability. JAMA. 2024;331(14):1205–1214. doi:10.1001/jama.2024.3172 6. Alemany S, Avella-García C, Liew Z, et al. Prenatal and postnatal exposure to acetaminophen in relation to autism spectrum and attention-deficit and hyperactivity symptoms in childhood: meta-analysis in six European population-based cohorts. Eur J Epidemiol. 2021 Oct;36(10):993-1004. doi: 10.1007/s10654-021-00754-4. 7. Ji Y, Azuine RE, Zhang Y, et al. Association of cord plasma biomarkers of in utero acetaminophen exposure with risk of attention-deficit/hyperactivity disorder and autism spectrum disorder in childhood. JAMA Psychiatry. 2020;77(2):180–189. doi:10.1001/jamapsychiatry.2019.3259

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-452 Overview: The healthcare landscape is undergoing a sea change, significantly impacting established, evidence-based recommendations. Media coverage suggests that the HHS Secretary plans to release a report linking acetaminophen use during pregnancy with an increased risk of autism spectrum disorder (ASD) in offspring as well as linking maternal folate deficiency with ASD—associations that have not been supported by evidence. If promoted by public health agencies, such discrepancies pose a dilemma for clinicians who have relied on and trusted that guidance reflects evidence and is grounded in scientific methods. Join us to review the evidence on acetaminophen and ASD risk and learn strategies to ensure your practice is based on valid findings. Episode resource links: Ahlqvist VH, Sjöqvist H, Dalman C, et al. Acetaminophen Use During Pregnancy and Children's Risk of Autism, ADHD, and Intellectual Disability. JAMA. 2024;331(14):1205–1214. doi:10.1001/jama.2024.3172   Damkier, P., Gram, E. B., Ceulemans, M., Panchaud, A., Cleary, B., Chambers, C., Weber-Schoendorfer, C., Kennedy, D., Hodson, K., Grant, K. S., Diav-Citrin, O., Običan, S. G., Shechtman, S., & Alwan, S. (2025). Acetaminophen in Pregnancy and Attention-Deficit and Hyperactivity Disorder and Autism Spectrum Disorder. Obstetrics and gynecology, 145(2), 168–176. https://doi.org/10.1097/AOG.0000000000005802   Ji Y, Azuine RE, Zhang Y, et al. Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood. JAMA Psychiatry. 2020;77(2):180–189. doi:10.1001/jamapsychiatry.2019.3259   Hirota T, King BH.  Autism Spectrum Disorder: A Review. JAMA. 2023;329(2):157–168. doi:10.1001/jama.2022.23661   Liu, X., Zou, M., Sun, C., Wu, L., & Chen, W. X. (2022). Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression. Journal of autism and developmental disorders, 52(2), 522–539. https://doi.org/10.1007/s10803-021-04951-8   DSM-5-TR: Neurocognitive Disorders Supplement; October 2022. https://psychiatryonline.org/pb-assets/dsm/update/DSM-5-TR_Neurocognitive-Disorders-Supplement_2022_APA_Publishing.pdf https://www.npr.org/sections/shots-health-news/2025/09/06/nx-s1-5532143/hhs-responds-to-report-about-autism-and-acetaminophen Guest: Susan Feeney, DNP, FNP-BC, NP-C   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com   

Credits: 0.25 AMA PRA Category 1 Credit™   CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-452 Overview: The healthcare landscape is evolving rapidly, and clinicians are navigating conflicting guidance on established, evidence-based recommendations. Recent news suggest acetaminophen use during pregnancy causes autism spectrum disorder (ASD), which is not the consensus of medical experts based on available data. When guidance from various sources conflicts with established research, clinicians face challenges in providing evidence-based care. Join us to review the current evidence on acetaminophen and ASD risk.  Episode resource links: Ahlqvist VH, Sjöqvist H, Dalman C, et al. Acetaminophen Use During Pregnancy and Children's Risk of Autism, ADHD, and Intellectual Disability. JAMA. 2024;331(14):1205–1214. doi:10.1001/jama.2024.3172   Damkier, P., Gram, E. B., Ceulemans, M., Panchaud, A., Cleary, B., Chambers, C., Weber-Schoendorfer, C., Kennedy, D., Hodson, K., Grant, K. S., Diav-Citrin, O., Običan, S. G., Shechtman, S., & Alwan, S. (2025). Acetaminophen in Pregnancy and Attention-Deficit and Hyperactivity Disorder and Autism Spectrum Disorder. Obstetrics and gynecology, 145(2), 168–176. https://doi.org/10.1097/AOG.0000000000005802   Ji Y, Azuine RE, Zhang Y, et al. Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood. JAMA Psychiatry. 2020;77(2):180–189. doi:10.1001/jamapsychiatry.2019.3259   Hirota T, King BH.  Autism Spectrum Disorder: A Review. JAMA. 2023;329(2):157–168. doi:10.1001/jama.2022.23661   Liu, X., Zou, M., Sun, C., Wu, L., & Chen, W. X. (2022). Prenatal Folic Acid Supplements and Offspring's Autism Spectrum Disorder: A Meta-analysis and Meta-regression. Journal of autism and developmental disorders, 52(2), 522–539. https://doi.org/10.1007/s10803-021-04951-8   DSM-5-TR: Neurocognitive Disorders Supplement; October 2022. https://psychiatryonline.org/pb-assets/dsm/update/DSM-5-TR_Neurocognitive-Disorders-Supplement_2022_APA_Publishing.pdf https://www.npr.org/sections/shots-health-news/2025/09/06/nx-s1-5532143/hhs-responds-to-report-about-autism-and-acetaminophen Guest: Susan Feeney, DNP, FNP-BC, NP-C   Music Credit: Matthew Bugos Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com   

Send us a message with this link, we would love to hear from you. Standard message rates may apply.Screen time impacts our mental health in significant ways, with research suggesting particular risks for teens who spend more than three hours daily on social media.• Higher social media usage linked to increased rates of depression, anxiety, and stress• Teens more vulnerable to negative mental health effects than adults• Using social media to escape negative feelings raises mental health risks• Limiting social media to 30 minutes per day can lower depression and anxiety• Open conversations about online experiences help teens develop healthy digital habits• Unrealistic images and constant comparisons on social media harm self-worth• Adults experience similar but less pronounced negative effects from excessive screen time• Maintaining real-life relationships outside digital spaces provides important balance• Screen time isn't benign—moderation is key to protecting mental wellbeingCheck us out on Instagram, find us on Threads, or send us an email at yourcheckuppod@gmail.com.References1. Associations Between Time Spent Using Social Media and Internalizing and Externalizing Problems Among US Youth. Riehm KE, Feder KA, Tormohlen KN, et al. JAMA Psychiatry. 2019;76(12):1266-1273. doi:10.1001/jamapsychiatry.2019.2325.2. Impact of Social Media Use on Mental Health Within Adolescent and Student Populations During COVID-19 Pandemic: Review. Draženović M, Vukušić Rukavina T, Machala Poplašen L. International Journal of Environmental Research and Public Health. 2023;20(4):3392. doi:10.3390/ijerph20043392.3. Annual Research Review: Adolescent Mental Health in the Digital Age: Facts, Fears, and Future Directions. Odgers CL, Jensen MR. Journal of Child Psychology and Psychiatry, and Allied Disciplines. 2020;61(3):336-348. doi:10.1111/jcpp.13190.4. Addictive Screen Use Trajectories and Suicidal Behaviors, Suicidal Ideation, and Mental Health in US Youths. Xiao Y, Meng Y, Brown TT, Keyes KM, Mann JJ. JAMA. 2025;:2835481. doi:10.1001/jama.2025.7829.5. Exploring the Relationship Between Social Media Use and Symptoms of Depression and Anxiety Among Children and Adolescents: A Systematic Narrative Review. Saleem N, Young P, Yousuf S. Cyberpsychology, Behavior and Social Networking. 2024;27(11):771-797. doi:10.1089/cyber.2023.0456.6. Adolescents' Interactive Electronic Device Use, Sleep and Mental Health: A Systematic Review of Prospective Studies. Dibben GO, Martin A, Shore CB, et al. Journal of Sleep Research. 2023;32(5):e13899. doi:10.1111/jsr.13899.7. Relationship Between Depression and the Use of Mobile Technologies and Social Media Among Adolescents: Umbrella Review. Arias-de la Torre J, Puigdomenech E, García X, et al. Journal of Medical Internet Research. 2020;22(8):e16388. doi:10.2196/16388.Support the showSubscribe to Our Newsletter! Production and Content: Edward Delesky, MD & Nicole Aruffo, RNArtwork: Olivia Pawlowski

Interview with Sharmili Edwin Thanarajah, MD, author of Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations. Hosted by John Torous, MD. Related Content: Soft Drink Consumption and Depression Mediated by Gut Microbiome Alterations GLP-1 Receptor Agonists for Pharmacologically Induced Weight Gain

Most people retire with a solid income plan but no plan for a life they actually want to live. In this episode, I discuss the five human pillars that make retirement feel meaningful, not just financially viable: Purpose, Identity, Relationships, Structure, and Well-being. Expect punchy stories, research-backed insights, and practical prompts to start building a life worth funding. What you'll learn Why money ≠ meaning in retirement, and how outcomes beat incomes. The Five Pillars framework (Purpose, Identity, Relationships, Structure, Well-being) and how each one stabilises your next chapter. The hidden risk of identity loss after the job title disappears, and two better questions to ask yourself now. Why too much unstructured time can feel like freedom that turns to fog, and simple ways to add rhythm without losing flexibility. The science bits (in plain English): Only 27% of retirees report feeling very fulfilled day-to-day (Stanford Center on Longevity). A strong sense of purpose links to a 15% lower risk of death (JAMA Psychiatry). The Harvard Adult Development Study shows close relationships are the biggest predictor of long-term happiness. 1 in 4 experience mild to moderate depression post-retirement—often due to lost meaning, routine, and social contact (NHS). Challenge of the Week Score yourself 1–10 on each pillar: Purpose, Identity, Relationships, Structure, Well-being. Pick the lowest score and do one tiny action this week to move it up by one point (e.g., book coffee with a friend, start a 15-minute morning walk, schedule a creative hour, message someone to mentor). Small moves → big momentum. Resources & links Mentioned research (as cited in the episode): Stanford Center on Longevity — fulfilment in retirement JAMA Psychiatry (2020) — purpose & mortality risk Harvard Study of Adult Development — relationships & happiness NHS guidance/statistics — mental health in later life Want more? Connect with me on LinkedIn and share your Challenge of the Week answers. Buy my book The Retirement You Didn't See Coming Book a time for us to chat about your retirement plans Next episode “The Skill No One Taught You: Spending Money.” We'll get into guilt, scarcity, freedom, joy, and why many retirees have more than enough yet still struggle to spend with confidence.

Quick summaries of articles 51-60. Enjoy! 51. Fun Activities and Recovery Acuff, S. F., et al. A brief measure of non-drug reinforcement: Association with treatment outcomes during initial substance use recovery. Drug and Alcohol Dependence, 256, 111092. 52. Buprenorphine-precipitated Fentanyl Withdrawal Thakrar AP, et al. Buprenorphine-Precipitated Withdrawal Among Hospitalized Patients Using Fentanyl. JAMA Netw Open. 2024 Sep 3;7(9):e2435895. 53. Methadone Vs. Buprenorphine Nosyk B, Et al. Buprenorphine/Naloxone vs Methadone for the Treatment of Opioid Use Disorder. JAMA. 2024 Oct 17. 54. High Daily Doses of Buprenorphine Axeen S, et al. Association of Daily Doses of Buprenorphine With Urgent Health Care Utilization. JAMA Netw Open. 2024 Sep 3;7(9):e2435478. 55. How Buprenorphine Works in Pregnancy Caritis, Steve N. MD; et al. A Pharmacologic Evaluation of Buprenorphine in Pregnancy and the Postpartum Period. Journal of Addiction Medicine ():10.1097/ADM.0000000000001380, September 2, 2024. 56. How Many Quite Attempts Does It Take? Fontes RM, et al. Beyond the first try: How many quit attempts are necessary to achieve substance use cessation? Drug Alcohol Depend. 2024 Dec 8;267:112525. 57. What is Recovery? Zemore SE, et al. Understanding the Shared Meaning of Recovery From Substance Use Disorders: New Findings From the What is Recovery? Study. Subst Abuse. 2023 Sep 15;17:11782218231199372. 58. Semaglutide for Alcohol Use Disorder (The RCT) Hendershot CS, et al. Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2025 Feb 12:e244789. 59. Low-Dose Buprenorphine Initiation (Micro-induction) Suen LW, et al. Outpatient Low-Dose Initiation of Buprenorphine for People Using Fentanyl. JAMA Netw Open. 2025 Jan 2;8(1):e2456253. 60. Lisdexamfetamine for methamphetamine use disorder Ezard N, et al LiMA Investigator Group. Lisdexamfetamine in the treatment of methamphetamine dependence: A randomised, placebo-controlled trial. Addiction. 2024 Dec 19. --- This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES. CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/ --- Original theme music: composed and performed by Benjamin Kennedy Audio editing: Michael Bonanno Executive producer: Dr. Patrick Beeman A podcast from Ars Longa Media --- This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice. The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group. --- Email: addictionmedicinejournalclub@gmail.com Facebook: @AddictionMedJC Facebook Group: Addiction Medicine Journal Club Instagram: @AddictionMedJC Threads: @AddictionMedJC YouTube: addictionmedicinejournalclub Twitter/X: @AddictionMedJC --- Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities. Learn more about your ad choices. Visit megaphone.fm/adchoices

Interview with Anna D. Ratzliff, MD, PhD and Andrew J. Saxon, MD authors of Collaborative Care for Opioid Use Disorder in Primary Care: A Hybrid Type 2 Cluster Randomized Trial. Hosted by John Torous, MD. Related Content: Collaborative Care for Opioid Use Disorder in Primary Care

Concerned about screen time—both your kids' and your own? Perhaps you're navigating the decision of when to give your child a phone, or maybe you're rethinking past choices. While we all strive for improvement in managing screen time, our aim isn't to condemn technology or advocate for device-free living.Today, we welcome Dr. Ryan Sultan, an internationally recognized, double board-certified psychiatrist who directs the Sultan Mental Health Informatics and Adaptation Lab at Columbia University. Dr. Sultan offers expert guidance on discussing algorithms and short-form content with your children, fostering independent thinking. We'll also delve into the spread of misinformation and reactionary content, as well as the correlation between screen time and depression. Tune in for his practical advice on immediate steps you can take to help your kids gain better control over their screen time, even if they're already knee deep.(00:00:58) Welcome Dr. Ryan Sultan to the podcast.(00:04:25) If you only get one thing out of this conversation, THIS is it.(00:09:28) What is actually happening in the brain when we're using our phones? (00:15:27) Talking to our kids about algorithms.(00:21:20) When to introduce screens to kids and what age to give a phone.(00:26:16) Neurodivergence and devices: a higher risk group.(00:30:12) Heavy social media use and depression, anxiety,and suicidal ideation.(00:33:31) Multiplayer video games: are they social media?(00:36:10) Setting boundaries: a medium between doing nothing and taking it all away.(00:43:28) Sultan Lab Big Data for social media and mental health guidelines.(00:48:18) Parents, we need regulation and it's NOT impossible.(00:53:42) Summary and what to implement in your household right now to get better control over screen time.(00:56:00) Where to find Dr. Ryan Sultan. Integrative Psychiatry is a psychiatry practice that takes a holistic, collaborative approach to mental health care. The Columbia-trained clinical team provides expert, evidence-based treatment for ADHD, anxiety, depression, substance use, eating disorders, and other mental health conditions. The clinicians combine psychotherapy, research-supported psychotropic medications, and expertise as adult, adolescent, and child psychiatrists to deliver patient-centered care that meets each individual's unique needs—supporting long-term mental well-being and overall wellness.The practice is led by Dr. Ryan Sultan, an internationally recognized, double board-certified psychiatrist. He also serves as an Assistant Professor of Clinical Psychiatry at Columbia University, where he leads the Sultan Mental Health Informatics and Adaptation Lab.To learn more, visit Integrative Psychiatry or Sultan Lab. References:Sultan, R. S. (2017). Off-Label Prescribing of Antipsychotics for Youths: Who Should Be Treated? Psychiatric Times, 34(9), 26.Sultan, R. S., Liu, S. M., Hacker, K. A., & Olfson, M. (2021). Adolescents with Attention-Deficit/Hyperactivity Disorder: Adverse Behaviors and Comorbidity. Journal of Adolescent Health, 68(2), 284-291.Sultan, R. S., Saunders, D. C., & Veenstra-VanderWeele, J. (2025). Protective Effects of ADHD Medication on Real-World Outcomes. JAMA Psychiatry.Want to leave the TTSL Podcast a voicemail? We love your questions and adore hearing from you. https://www.speakpipe.com/TheThickThighsSaveLivesPodcast⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The CVG Nation app, for ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠iPhone⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠The CVG Nation app, for Android⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Our ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Fitness FB Group⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠.⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Thick Thighs Save Lives Workout Programs⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Constantly Varied Gear's ⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠Workout Leggings⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠⁠

What does it mean to be free? It's a question that's puzzled philosophers for millennia. But what does it mean to be metabolically free? If you've ever felt hangry, crashed after a meal, or dealt with type 2 diabetes, you've experienced the opposite — metabolic imprisonment.My guest today, Ben Azadi, knows this firsthand. In 2008, Ben was obese and unhealthy, struggling to find answers. After shedding 80 pounds and turning his health around, he dedicated his life to helping others do the same. Today, he's a functional health expert, bestselling author, and the founder of Keto Kamp, a global brand empowering people to use ancient healing tools like fasting and the ketogenic lifestyle. His new book, Metabolic Freedom: A 30-Day Guide to Restore Your Metabolism, Heal Hormones & Burn Fat, lays out the blueprint to reclaim your health.In this episode, we dive into:What metabolism really is — and why “slow” or “fast” metabolism may be a mythA groundbreaking study that disproves the idea that metabolism slows with ageWhy fasting insulin is a better marker of health than weight or glucose aloneThe surprising power of “Vitamin G” — gratitude — on your metabolic functionBen's top daily habits and biohacks to supercharge your metabolismBen's approach is all about education over medication — empowering you to take control, rather than outsourcing your health. Ben has also made a personal impact on a member of my family.Links:

Interview with Sameer Jauhar, PhD, author of Incidence and Nature of Antidepressant Discontinuation Symptoms: A Systematic Review and Meta-Analysis. Hosted by John Torous, MD. Related Content: Incidence and Nature of Antidepressant Discontinuation Symptoms

Interview with Aaron Alexander-Bloch, MD, PhD, and Kevin Y. Sun, BA, authors of Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence. Hosted by John Torous, MD. Related Content: Polygenic Risk, Psychopathology, and Personalized Functional Brain Network Topography in Adolescence

Contributor: Jorge Chalit-Hernandez, OMS3 Educational Pearls: Psychedelics are being studied for their therapeutic effects in mental illnesses, including major depressive disorder, post-traumatic stress disorder, anxiety, and many others Classic psychedelics include compounds like psilocybin, LSD, and ayahuasca MDMA and ketamine are often included in psychedelic research, but have a different mechanism of action than the others Their mechanism of action involves agonism of the 5HT2A receptor, among others Given their resurgence, there is an increase in recreational use of these substances A recent study assessed the risks of recreational users developing subsequent psychotic disorders Individuals who visited the ED for hallucinogen use had a greater risk of being diagnosed with a schizophrenia spectrum disorder in the following 3 years Hazard ratio (HR) of 21.32 After adjustment for comorbid substance use and other mental illness, the hazard ratio was 3.53 - still a significant increase compared with the general population They also found an elevated risk for psychedelics when compared to alcohol (HR 4.66) and cannabis (HR 1.47) The study did not assess whether patients received antipsychotics or other treatments in the ED References Lieberman JA. Back to the Future - The Therapeutic Potential of Psychedelic Drugs. N Engl J Med. 2021;384(15):1460-1461. doi:10.1056/NEJMe2102835 Livne O, Shmulewitz D, Walsh C, Hasin DS. Adolescent and adult time trends in US hallucinogen use, 2002-19: any use, and use of ecstasy, LSD and PCP. Addiction. 2022;117(12):3099-3109. doi:10.1111/add.15987 Myran DT, Pugliese M, Xiao J, et al. Emergency Department Visits Involving Hallucinogen Use and Risk of Schizophrenia Spectrum Disorder. JAMA Psychiatry. 2025;82(2):142-150. doi:10.1001/jamapsychiatry.2024.3532 Summarized & Edited by Jorge Chalit, OMS3 Donate: https://emergencymedicalminute.org/donate/  

Interview with Pim Cuijpers, PhD, author of Cognitive Behavior Therapy for Mental Disorders in Adults: A Unified Series of Meta-Analyses. Hosted by John Torous, MD Related Content: Cognitive Behavior Therapy for Mental Disorders in Adults

In episode 58 we discuss a randomized controlled trial of semaglutide for alcohol use disorder.    Hendershot CS, Bremmer MP, Paladino MB, Kostantinis G, Gilmore TA, Sullivan NR, Tow AC, Dermody SS, Prince MA, Jordan R, McKee SA, Fletcher PJ, Claus ED, Klein KR. Once-Weekly Semaglutide in Adults With Alcohol Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2025 Feb 12:e244789.     We also discuss benzodiazepine tapering guidelines and new ways to use Sublocade.    ASAM Clinical Practice Guideline on Benzodiazepine Tapering  Sublocade label changes  ---  This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.  CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/  ---  Original theme music: composed and performed by Benjamin Kennedy  Audio editing: Michael Bonanno  Executive producer: Dr. Patrick Beeman  A podcast from Ars Longa Media  ---   This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.   The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.  Email: addictionmedicinejournalclub@gmail.com   Facebook: @AddictionMedJC  Facebook Group: Addiction Medicine Journal Club  Instagram: @AddictionMedJC   Threads: @AddictionMedJC  YouTube: addictionmedicinejournalclub   Twitter/X: @AddictionMedJC   Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.  Learn more about your ad choices. Visit megaphone.fm/adchoices

In this episode Dr's J and Santhosh do a deep dive and chew the fat on the facts about ozempic, wegovy and the current crop of weight loss drugs. Along the way they cover gila monsters, synthetic insulins, lizard venom salesmen, ozempic and wegovy differences, cardioprotective and neuroprotective effects, ozempic pregnancies, addiction and reward treatment, kidney protection, prevention of brain shrinkage, alzheimers delay ozempic face and more! So sit back and relax as we cover the many faces of ozempic!Further ReadingJournal reference: JAMA Psychiatry DOI: 10.1001/jamapsychiatry.2024.4789https://www.nejm.org/doi/10.1056/NEJMoa2208601https://www.imperial.ac.uk/news/255214/weight-loss-drug-slow-alzheimers-decline/https://pubmed.ncbi.nlm.nih.gov/35180937/https://www.nature.com/articles/d41586-024-01564-whttps://www.nejm.org/doi/full/10.1056/NEJMoa2307563Support Us spiritually, emotionally or financially here! or on ACAST+travelmedicinepodcast.comBlueSky/Mastodon/X: @doctorjcomedy @toshyfroTikotok: DrjtoksmedicineGmail: travelmedicinepodcast@gmail.comSpotify: https://open.spotify.com/show/28uQe3cYGrTLhP6X0zyEhTPatreon: https://www.patreon.com/travelmedicinepodcast Supporting us monthly has all sorts of perks! You get ad free episodes, bonus musical parody, behind the scenes conversations not available to regular folks and more!! Your support helps us to pay for more guest interviews, better equipment, and behind the scenes people who know what they are doing! https://plus.acast.com/s/travelmedicinepodcast. Hosted on Acast. See acast.com/privacy for more information.

Measles cases are rising in Texas and New Mexico, with most infections occurring in unvaccinated individuals and public health officials warning of further spread. A new study in JAMA Psychiatry found that semaglutide significantly reduces alcohol craving and heavy drinking, suggesting a potential new treatment for alcohol use disorder. Research confirms that self-sampling for HPV is as effective as speculum-based exams, improving accessibility for women with disabilities and underserved populations. With the FDA's recent approval, self-collection could revolutionize cervical cancer screening in the U.S.