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Featuring perspectives from Dr Karim Fizazi, Dr Daniel George and Dr Elisabeth I Heath, moderated by Dr Heath, including the following topics: Tolerability of capivasertib and management of associated side effects — Question from Neeraj Agarwal, MD, FASCO (0:00) Case: A man in his early 70s with Type 2 diabetes presents with metastatic hormone-sensitive prostate cancer with widespread bone metastases and PTEN deficiency on next-generation sequencing and receives relugolix/darolutamide — Rana R McKay, MD, FASCO (8:39) CME information and select publications
Alberta is one Canadian craft beer scene that we haven't tapped into enough, so we're fixing that right now - we were stoked to sit down with one of the most hyped breweries in Calgary. Production Manager and Head Brewer Donovan Fast leads the liquid for Eighty-Eight Brewing Co., and he joined Cee and Nate to chat about his international craft brewing career that took him from Manitoba to Germany to Alberta, what he learned from the classic German brewers, how he landed the Head Brewer job before Eighty-Eight opened (and has been the sole Head Brewer in their history), how the Calgary craft beer scene has grown over the years, how Eighty-Eight went from a Belgian-style brewery to a more modern, IPA-focused brewery and COVID's effect on that decision, the slew of awards they've won, their core-to-seasonal beer release strategy, his thoughts on Canada-wide distribution and Eighty-Eight's approach, their interprovincial collaborations, how their eighth anniversary went, and the future of the brewery. They got into six absolute bangers from Eighty-Eight: Midnight Downtown Rice Lager, Hammer Pants West Coast Pale Ale, Hi-Fi Hazy IPA, Pop Rocks Fruited Sour with pink guava + berries, Wave Pool Tropical IPA, and Party All The Time Double NEIPA. This was so dope - more Alberta content on the way! BAOS Podcast Subscribe to the podcast on YouTube | Website | Theme tune: Cee - BrewHeads
Frank Beckx begon een jaar geleden als topman bij Voka, het Vlaams netwerk van ondernemingen. Trends heeft deze week het netwerk en de machtsbasis van de nieuwe gedelegeerde bestuurder in kaart gebracht. Adjunct-hoofdredacteur Jan De Meulemeester legt uit. Hosts: Laurens Bouckaert en Jan De Meulemeester Trends is een podcastkanaal van de redactie van Trends.--- --- Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
How did you learn about computers? And how in depth was your education? For some the answer is the Bi-Tran Six: an educational machine released in 1965. This was one of the first computer trainers, and it represents a very interesting take on design. It's a machine that's small, simple, and can even be disassembled while running. But exactly how was it designed, and what was it used for? What makes the Bi-Tran Six so different from other machines? Like Advent of Computing? Then check out the after show! Adjunct of Computing is now LIVE: YouTube Spotify Apple Podcasts
The Elective Rotation: A Critical Care Hospital Pharmacy Podcast
Show notes at pharmacyjoe.com/episode1161 In this episode, I'll discuss acetazolamide instead of metolazone as an adjunct to loop diuretics.
The Elective Rotation: A Critical Care Hospital Pharmacy Podcast
Show notes at pharmacyjoe.com/episode1160 In this episode, I'll discuss Acetazolamide instead of metolazone as an adjunct to loop diuretics.
Featuring perspectives from Dr Terence Friedlander, Dr Matthew Galsky, Dr Shilpa Gupta and Prof Andrea Necchi, moderated by Dr Friedlander, including the following topics: Case: A patient with T4 disease, pelvic wall involvement and a positive pelvic node treated as metastatic disease with enfortumab vedotin and pembrolizumab attains a complete response on imaging after 6 cycles (0:00) Case: A man with muscle-invasive bladder cancer who receives neoadjuvant chemotherapy with durvalumab receives positive circulating tumor DNA results before cystectomy and negative results after surgery (7:41) CME information and select publications
Featuring perspectives from Dr Terence Friedlander, Dr Matthew Galsky, Dr Shilpa Gupta and Prof Andrea Necchi, moderated by Dr Friedlander, including the following topics: Case: A man in his early 80s with non-muscle-invasive bladder cancer (NMIBC) monitored by repeat TURBTs develops localized muscle-invasive bladder cancer and enrolls in a clinical trial of neoadjuvant enfortumab vedotin with pembrolizumab (0:00) Case: A man in his late 70s with newly diagnosed NMIBC with carcinoma in situ (CIS) receives BCG induction and experiences relapse of CIS during BCG maintenance (9:24) CME information and select publications
One of the newest breweries in Ontario (at the time of recording) is Prince Edward County's Aurum. Meaning "gold" in Latin, their slogan "Drink Gold" is incredibly appropriate for a brewery that focuses mostly on German and Czech-style Lagers and Ales. Co-Founder and Head Brewer Prat joined Cee and Nate to chat about his eclectic beer history - from India to Ontario, how he met his Co-Founder Joe and how they came across the space that turned into Aurum, why they chose the County and why they focus on the styles that they do, Prat's experiences in Germany and the Czech Republic that shaped what he brews, the beauty of LUKR taps and educating the public about mlíko pours, the drinking preferences of their locals in the County, how the fellow breweries in PEC have embraced them and collaborated with them, and their approach to distribution. They got into six killer Aurum brews - Rybička 8° Czech Pale Lager, Denní 12° Czech-style Pilsener, Lys French Inspired Pils, Himmel Bavarian-style Wheat Beer, Nü-01 Dry-Hopped Lager, and Sequoia West Coast Pils collaboration with All My Friends. This was fantastic - excited to follow their journey! BAOS Podcast Subscribe to the podcast on YouTube | Website | Theme tune: Cee - BrewHeads
Het Brusselse autoleasebedrijf LIZY kondigde vanochtend op onze site trends.be aan dat ze een megabedrag van 300 miljoen euro gaan bijtanken. Adjunct-hoofdredacteur van Trends Jan De Meulemeester legt uit. Hosts: Jan De Meulemeester en Jens Leen Trends is een podcastkanaal van de redactie van Trends.--- --- Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Featuring perspectives from Dr Karim Fizazi, Dr Daniel George and Dr Elisabeth I Heath, moderated by Dr Heath, including the following topics: Treatment approach for AKT-mutated prostate cancer — Question from Neeraj Agarwal, MD, FASCO (0:00) Case: A man in his late 60s with de novo metastatic hormone-sensitive prostate cancer with widespread skeletal metastases and PTEN loss on next-generation sequencing receives relugolix/darolutamide with chemotherapy and experiences PSA decline that plateaus at approximately 1 ng/mL — Rana R McKay, MD, FASCO (10:29) CME information and select publications
Featuring perspectives from Dr Karim Fizazi, Dr Daniel George and Dr Elisabeth I Heath, moderated by Dr Heath, including the following topics: Role of PTEN deficiency in tumorigenesis of prostate cancer and optimal approach to PTEN assessment — Question from Neeraj Agarwal, MD, FASCO (0:00) Case: A man in his late 60s with a history of nonmetastatic hormone-sensitive prostate cancer (HSPC) that progressed to metastatic HSPC with PTEN loss by next-generation sequencing of primary archival tissue from 2017 receives abiraterone for 2 years — Rana R McKay, MD, FASCO (8:26) CME information and select publications
It feels like almost every year we end up taking some sort of a short pause over the summer for obvious reasons, but in 2026, it was a little longer than usual. Both Cee and Nate were off galavanting across the globe, so we figured the best way to ease back into the pod was to run through all the shenanigans they got up to. Here's some teasers to get you going: Nate spent time in glorious Mexico soaking up the few beer options available, along with sampling a much wider variety of fire in Rimouski and Saint-Flavie in Quebec. Cee, on the other hand, was going nuts in places like California, England, Scotland, Wales, Germany, Thailand, Australia, France and Italy. The fellas told some stories from their travels and covered the beers they got into, along with some obligatory coffee talk. They got into a gang of beers that each represented places they went. Nate cracked Dos Equis Lager Especial, Tecate Original, Le Ketch Dock 151 NEIPA, and Bad Bones Ambulance NEIPA. Cee got into Crowns & Hops The Dopest Hazy IPA, Innis & Gunn Caribbean Rum Cask Scottish Red Ale, Hofbräuhaus München Dunkel, Banks Cantina Mexican Lager, Kronenbourg 1664 Lager, and Birra Moretti Italian Lager. This was a fun one - happy to be back! BAOS Podcast Subscribe to the podcast on YouTube | Website | Theme tune: Cee - BrewHeads
België is vandaag een hockeyland om rekening mee te houden. De Red Lions werden wereldkampioen, Europees kampioen en olympisch kampioen. Ook de Red Panthers behoren steeds meer tot de internationale top. Maar dat succes is niet uit de lucht komen vallen. Amper twintig jaar geleden was hockey in België nog grotendeels een amateuristische sport, vooral bekend binnen een beperkt aantal clubs en regio's. Adjunct-hoofdredacteur Jan De Meulemeester duidt het verhaal achter onze Belgische hockeysuccessen. Hosts: Jan De Meulemeester en Jens Leen Trends is een podcastkanaal van de redactie van Trends.--- --- Hosted by Simplecast, an AdsWizz company. See pcm.adswizz.com for information about our collection and use of personal data for advertising.
Binary is synonymous with digital computing. But is it the only way to crunch numbers? The short answer is no. The long answer, well, that's today's topic. Today we are talking about ternary, aka base 3. From it's early uses in the 19th century, to actual computers, and even theoretical designs; ternary proves to be a difficult topic to track down... and a very unique one. Selected sources: https://www.mortati.com/glusker/fowler/fowlerbio.htm - Information and a reconstruction of Fowler's contraption https://dl.acm.org/doi/epdf/10.1145/776378.776392 - Part I of the TERNAC papers, rationale! Like Advent of Computing? Then check out the after show! Adjunct of Computing is now LIVE: YouTube Spotify Apple Podcasts
Featuring perspectives from Dr Terence Friedlander, Dr Matthew Galsky, Dr Shilpa Gupta and Prof Andrea Necchi, moderated by Dr Friedlander, including the following topics: Case: A woman in her late 60s with T3N0 upper tract urothelial carcinoma that was resected has no evidence of disease on imaging, receives negative circulating tumor DNA results and elects observation instead of adjuvant treatment (0:00) Case: A man in his late 70s with PD-L1-negative high-grade muscle-invasive bladder cancer who is ineligible for cisplatin because of poor renal function undergoes cystectomy (10:12) CME information and select publications
Featuring perspectives from Dr Terence Friedlander, Dr Matthew Galsky, Dr Shilpa Gupta and Prof Andrea Necchi, moderated by Dr Friedlander, including the following topics: Case: A healthy man in his early 70s who received several different lines of therapy for non-muscle-invasive bladder cancer (NMIBC), wants to avoid radical cystectomy and does not want pembrolizumab (0:00) Case: A man in his late 70s with newly diagnosed NMIBC with carcinoma in situ (11:20) CME information and select publications
This is your All Local 4pm update for August 8th, 2026.
In 1950 Northrup unveiled their MAgnetic Drum DIgital Differential Analyser. The machine is a wild piece of technology; a rendering of an analog computer in digital encoding. But how did we get here? How did a project to guide a missile lead to a mass produced computer? And what does it have to do with suspiciously dry martinis? Selected Sources: https://sci-hub.st/10.1109/MAHC.2003.1179869 - 2003 paper on MADDIDA Like Advent of Computing? Then check out the after show! Adjunct of Computing is now LIVE: YouTube Spotify Apple Podcasts
In part three of this series, Dr. Aaron Zelikovich discusses the clinical outcomes seen during and after the acute infection and how these findings can guide physicians in counseling their patients. Show citation: Solomon T, Hooper C, Easton A, et al. Safety and efficacy of adjunct dexamethasone in adults with herpes simplex virus encephalitis in the UK (DexEnceph): a multicentre, observer-blind, randomised, phase 3, controlled trial. Lancet Neurol. 2026;25(2):136-146. doi:10.1016/S1474-4422(25)00454-5
Sermons from First Parish Unitarian Universalist of Arlington Massachusetts
Rev. Carolyn Patierno, Adjunct Minister, preaching Worship service given June 7, 2026 Prayer by Rev. Dr. Jonipher Kwong, Interim Lead Minister https://firstparish.info/ First Parish A liberal religious community, welcoming to all First gathered 1739 Join us for our final in-person worship service of the program year as Rev. Carolyn Patierno asks: How does faith carry us to higher ground especially in times when we feel we are desperately treading water? What does that mean as UUs? The First Parish Intergenerational Orchestra and the First Parish Choir, with accompanist Ken Seitz, will offer music as we bid farewell to this program year. Offering and Giving First The Giving First program donates 50% of the non-pledge offering each month to a charitable organization that we feel is consistent with Unitarian Universalist principles. The program began in November 2009, and First Parish has donated over $200,000 to more than 70 organizations. For June, July, and August of 2026, the Pink Haven Coalition will share half the offering collected during Sunday worship at First Parish. Pink Haven is a coalition of trans organizers, mutual-aid groups, progressive faith organizations, queer associations, and individual justice-lovers who are working together to create networks of safety and direct support for trans beloveds and their families who need to relocate, access healthcare across state lines, or stay as safe as possible where they are.. We know that liberation is a group project and that no one is free until everyone is free. We proclaim that trans lives are sacred. Pink Havens' work centers trans lives and experiences, particularly the lives and experiences of BIPOC trans and gender expansive people. Learn more at their website: https://www.pinkhaven.org/. The remaining half of your offering supports the life and work of this Parish. To donate using your smartphone, you may text "fpuu" to 73256. Then follow the directions in the texts you receive.
Sun protection you can eat? Yes, you heard that right. This week, we're joined by Dr. Noreen Galaria as she walks us through the many facets of the polypodium leaf. Listen in as she discusses sun protection, supplement standards, and the very latest research on conventional and traditional treatments. Each Thursday, join Dr. Raja and Dr. Hadar, board-certified dermatologists, as they share the latest evidence-based research in integrative dermatology. For access to CE/CME courses, become a member at LearnSkin.com. Noreen Galaria, MD FAAD is a board certified Dermatologist with a laser and cosmetic fellowship and has been practicing for over 20 years. After spending time as an academic dermatologist; training residents and doing research and publishing papers she moved into private practice 15 years ago and opened 3 offices outside of the DC area. Her research spans both conventional allopathic medicine and evidence based naturopathic therapies with a focus on integrative dermatologic care. She is also the CEO and Founder of Inner Glow Vitamins (A Dermatologist and Plastic surgeon developed brand of skin nutraceuticals). ¹ Research on polypodium has been published and presented at leading dermatology conferences, including the American Academy of Dermatology (AAD) and the Society for Pediatric Dermatology (SPD). Archives of Dermatological Research (2025) 317:580. https://doi.org/10.1007/s00403-025-04055-8 | Thakker S, Hussain A. J Am Acad Dermatol. 2025;93(3 Suppl):AB320. | Hakim C, et al. Presented at SPD 50th Annual Meeting; July 2025; Seattle, WA.
I've been browsing old compur surveys and trying to build up a comprehensive data set. What I've found is a little surprising: between late 1945 and 1949 only 10 new computers entered service. Once we get to the 50s that number explodes. What's going on here? What caused the gap between the first digital machines and the explosion of computers in the 50s? In this episode I try to answer that question by finding out just what was going on during this digital gap. Like Advent of Computing? Then check out the after show! Adjunct of Computing is now LIVE: YouTube Spotify Apple Podcasts
Could ketogenic therapy help people with schizophrenia spectrum disorders engage more successfully with CBT? A new conceptual framework explores this powerful adjunctive approach.CBTp is considered a gold-standard treatment for schizophrenia spectrum disorders, but many patients struggle to initiate, participate in, and complete it. Cognitive deficits, sleep disturbances, low distress tolerance, and ongoing psychotic symptoms can all stand in the way. In this conversation, Dr. Bret Scher sits down with licensed clinical social worker Nicole Laurent to discuss her recently published paper in Frontiers in Psychology, exploring how ketogenic metabolic therapy could help bridge that gap.In this conversation, you'll learn:Why CBTp is so cognitively demanding and where patients tend to struggleHow ketogenic therapy may reduce key barriers like sleep issues, distress tolerance, and cognitive impairmentWhat a conceptual analysis paper is and why it matters for shaping future researchHow clinicians and researchers can begin integrating these ideas into practiceWhether this framework could extend to CBT for depression, OCD, and anxietyThis discussion opens the door to thinking about ketogenic therapy not only as a direct treatment for psychiatric symptoms, but as a powerful adjunctive tool that could help patients engage more fully with the rest of their care.
Sermons from First Parish Unitarian Universalist of Arlington Massachusetts
Rev. Carolyn Patierno, Adjunct Minister, preaching Worship service given May 24, 2026 Prayer by Rev. Carolyn Patierno, Adjunct Minister https://firstparish.info/ First Parish A liberal religious community, welcoming to all First gathered 1739 As the nation honors the war-dead, it is as important to honor the way of peace, especially in this war-torn time. Join us this Memorial Day weekend as Adjunct Minister Rev. Carolyn Patierno reflects on peace in this moment. Offering and Giving First The Giving First program donates 50% of the non-pledge offering each month to a charitable organization that we feel is consistent with Unitarian Universalist principles. The program began in November 2009, and First Parish has donated over $200,000 to more than 70 organizations. For May 2026, The First Pioneer Valley Dream Center will share half the offering collected during Sunday worship at First Parish. The First Pioneer Valley Dream Center, based in Springfield, MA, provides essential services like food and clothing at no cost to struggling families and individuals from all walks of life. Living their call to love and serve God and others, their goal is to inspire hope and empower lives. One of their services is to provide purpose-driven volunteer work to the residents of the local correctional facility where one of our First Parish members was housed recently. This member nominated the organization in recognition of their excellent work and in gratitude for the care and support they offered her during her service at the Dream Center. Learn more at their website: https://firstpvdreamcenter.org/. The remaining half of your offering supports the life and work of this Parish. To donate using your smartphone, you may text "fpuu" to 73256. Then follow the directions in the texts you receive.
On this episode, I speak wtih Léonard Boussioux — Assistant Professor, Foster School of Business; Adjunct, Paul G. Allen School of Computer Science & Engineering, UW. PhD, MIT (machine learning & operations research). Co-founder of Universal AI. "Professor Leo," as his students call him, is a leader in AI education, research, experimentation, and adoption. He and I are on the Foster AI Taskforce, and sat down for this conversation in August of 2025. Leo rejects the career advice you've heard your entire life: pick a lane, specialize, go deep. His counter-argument is that AI now lets you be — in his words — a specialist of everything. In this conversation, we dig into what that actually means for MBA students, career switchers, and anyone trying to figure out how to use AI without offloading their thinking to it. We cover how Leo teaches non-coders to ship working products in a single class session, how he uses six different AI models to plan a vacation (and why), the new category of jobs emerging around human-AI collaboration, and why the people who panic about AI are usually the ones who haven't played with it yet. 3 Key Takeaways 1. Drive the AI. Don't delegate to it. The students who get worse at thinking are the ones who treat AI as a ghostwriter. The ones who get sharper treat it as a collaborator — pushing it in specific directions, rejecting outputs, iterating. 2. Build something this weekend. Reading about AI is not learning AI. Leo's students — most with zero coding background — ship working websites and games in a single class. Vibe coding tools like Lovable have collapsed the gap between idea and prototype to minutes. If you're an MBA recruiting into product, strategy, or consulting, the ability to prototype your own thinking is now a baseline skill, not a bonus. 3. The new jobs are at the human-AI seam. Automation creates a new category of work: deciding where humans belong in the loop, designing the workflows, catching the 5% of edge cases that have outsized consequences. Moderator, orchestrator, AI workflow consultant — these roles barely existed two years ago. Position yourself there. Learn more about Leo at https://leobix.com, or on LinkedIn.
Probiotics: A Promising Adjunct to Non-surgical Periodontal Therapy?By Today's RDH ResearchOriginal article published on Today's RDH: https://www.todaysrdh.com/probiotics-a-promising-adjunct-to-non-surgical-periodontal-therapy/Need CE? Start earning CE credits today at https://rdh.tv/ce Get daily dental hygiene articles at https://www.todaysrdh.com Follow Today's RDH on Facebook: https://www.facebook.com/TodaysRDH/Follow Kara RDH on Facebook: https://www.facebook.com/DentalHygieneKaraRDH/Follow Kara RDH on Instagram: https://www.instagram.com/kara_rdh/
Featuring proceedings from a live event on January 9, 2026, held adjunct to the 2026 ASCO Gastrointestinal Cancers Symposium and moderated by Dr Samuel J Klempner, including the following topics: Treatment approach for metastatic HER2-negative, claudin 18.2-positive, microsatellite instability-high gastroesophageal (GE) cancer (0:00) Duration of chemotherapy for patients with advanced GE cancers receiving nivolumab/chemotherapy (3:06) Younger patient with metastatic PD-L1-positive gastric cancer (5:29) CME information and select publications
What connects IBM, the NSA, the Third Reich, and high fidelity recordings of symphonies? The answer is: magnetic drum memory. Join me as I lose all track of scope and plot to discovery just how and why magnetic drum memory was invented. Like Advent of Computing? Then check out the after show! Adjunct of Computing is now LIVE: YouTube Spotify Apple Podcasts
There was a time when "adjunct" meant "cheap beer." One of America's largest breweries even paid millions of dollars to run television commercials during the Super Bowl accusing another of America's largest breweries of using worse adjuncts than they themselves used.Oh, what a world!But for craft breweries, an ingredient is an ingredient. What if adjuncts added flavor? What if adjuncts actually cost more than malted barley? What if adjuncts could tell a story of time and place?Corn and rice aren't cheap anymore. They have a history. They tell a story. And good breweries know how to use ingredients to tell the story of great beer. Visit AllAboutBeer.com for more podcasts, to read original articles, and to get info on upcoming events.Click here to support independent journalism covering the beer industry.This Episode is Sponsored by:All About BeerAt All About Beer, we're honored to share the stories that define the beer community, and we couldn't do it without the generous support of our underwriting sponsors. Their commitment helps sustain independent beer journalism, allowing us to highlight the people, places, and passion behind every pint. Their partnership ensures these stories continue to inspire, connect, and celebrate the craft we all love. Join our underwriters today and help make an impact on independent journalism covering the beer industry.Host: Don TseGuests: Doug Reiser, Tom Beckmann, Chris PiscitelloSponsors: All About BeerTags: Rice, Corn, Brewing Photo: by Don Tse
From the very earliest days of what we now know as craft beer, flavor has been a defining factor and a guiding mantra for brewers casting themselves against the monolith of light macro lager that dominated American brewing for so many decades. If you track it back, fruits and spices have been ingredients in beer for as long as beer has been made, so this modern era of craft brewing is more rediscovery than revolution. But there's no denying that familiar and enticing, or even exotic and intriguing, flavors have been an incredible draw in bringing people into the fold who might never have considered themselves beer drinkers. Of course, the ways we can add those fruit and spice flavors to beer have evolved significantly from the earliest days of craft brewing, and brewers now have tools to target and dial in fruit and spice notes with incredible precision—something that is increasingly important as brewers explore low-ABV and nonalcoholic beers and beverages. In this episode, produced in partnership with Amoretti, we explore best practices for delivering flavor impact that's noticeable, authentic, seamless, and artful, but that also works to support the bottom line for breweries facing ever-increasing input costs. Joining the discussion are: Michael Lalli, brewmaster, Krebs Brewing and Prairie Artisan Ales (Krebs, Oklahoma) Micah Rush, R&D manager, The Bruery and Offshoot Beer (Placentia, California) Nic Bortolin, brewmaster and brand ambassador, Amoretti To connect directly with Nic Bortolin for questions or more information, please email him at Nic@amoretti.com.
Attia Qureshi examines negotiation not simply as a business skill, but as a core leadership capability that shapes influence, alignment, and decision-making. Drawing on experience across consulting, startups, academia, and international development, she explains why many capable professionals struggle in negotiations despite strong analytical skills. The discussion explores several practical themes: why preparation is often undervalued, how fear and emotional reactions affect judgment under pressure, and why negotiation should be treated as a skill built through repetition rather than theory alone. Qureshi also distinguishes influence from manipulation, emphasizing that durable cooperation is built through trust, reciprocity, and understanding shared interests. The episode covers organizational alignment, stakeholder management, rejection, and emotional resilience, including lessons from work in Colombia helping farming communities transition away from coca production. Throughout the conversation, Qureshi argues that effective negotiators are not necessarily the most aggressive or persuasive, but the ones who can stay disciplined, build trust, and navigate difficult conversations with clarity and composure. This episode offers practical insights for leaders seeking to improve negotiation, relationship management, and organizational effectiveness in both professional and personal settings. Attia Qureshi is an adjunct at the Ford School of Public Policy and previously at MIT's Sloan School of Management and Ross School of Business. The founder of Attia Qureshi Consulting, where she supports companies through negotiation, conflict resolution, and organizational strategy. Get Attia's book, Never Settle, here: https://tinyurl.com/2fyjhb5m Claim your free gift: Free gift #1 McKinsey & BCG winning resume www.FIRMSconsulting.com/resumePDF Free gift #2 Breakthrough Decisions Guide with 25 AI Prompts www.FIRMSconsulting.com/decisions Free gift #3 Five Reasons Why People Ignore Somebody www.FIRMSconsulting.com/owntheroom Free gift #4 Access episode 1 from Build a Consulting Firm, Level 1 www.FIRMSconsulting.com/build Free gift #5 The Overall Approach used in well-managed strategy studies www.FIRMSconsulting.com/OverallApproach Free gift #6 Get a copy of Nine Leaders in Action, a book we co-authored with some of our clients: www.FIRMSconsulting.com/gift
Caroline Bicks joins Writer's Voice to talk about Monsters in the Archives, her fascinating exploration of Stephen King's private papers, creative process, and the deep emotional fears beneath his horror fiction. Then Marie Adelmann discusses Adjunct, her darkly funny and painfully real novel about precarious academic labor, student debt, and the exploitation built into today's university system. Two compelling conversations about fear, power, and survival in contemporary American life.
In 1947 Raytheon signed a contract to make their first computer. It would be their last... at least for many many years. The fruits of this contract was RAYDAC. Early digital computers were odd, to say the least. And RAYDAC distinguishes itself. From zig-zag delay lines to hunting tapes to freon cooling, it truly is a unique machine. Selected Sources: https://ed-thelen.org/McGee_Book-4.2.2.pdf - McGee on his experience programming RAYDAC https://sci-hub.st/10.1109/JRPROC.1948.232626 - A Digital Computer for Scientific Applications https://www.jstor.org/stable/2002859 - The Logical Design of RAYDAC Like Advent of Computing? Then check out the after show! Adjunct of Computing is now LIVE: YouTube Spotify Apple Podcasts
Dr Stacey A Cohen from Fred Hutchinson Cancer Center in Seattle, Washington, Dr Jenny Seligmann from the University of Leeds in the United Kingdom and Dr Christopher Lieu from the University of Colorado Cancer Center in Aurora review clinical findings from the 2026 ASCO Gastrointestinal Cancers Symposium relevant to the management of localized colorectal cancer. CME information and select publications here.
Featuring perspectives from Dr Stacey A Cohen, Dr Christopher Lieu and Dr Jenny Seligmann, moderated by Dr Lieu, including the following topics: Role of circulating tumor DNA (ctDNA) testing in the escalation of treatment for Stage II and deescalation for Stage III colon cancer (0:00) Impact of timing on the clinical relevance of ctDNA minimal residual disease test results in localized colorectal cancer (8:58) Approach to managing Stage III colon cancer with ctDNA-positive results after adjuvant treatment (13:35) CME information and select publications
Featuring perspectives from Dr Jaffer A Ajani, Dr Samuel J Klempner, Dr Rutika Mehta and Dr John Strickler, moderated by Dr Klempner, including the following topics: Role of PD-L1 status, tumor histology and pulmonary disease in selection of immune checkpoint inhibition as up-front therapy (0:00) Impact of metastatic site and autoimmune disease on clinical decision-making in the use of immune checkpoint inhibition (5:56) Biomarker assessment approach and treatment selection (10:50) CME information and select publications
The image of a mainframe is almost always accompanied by it's companion: the magnetic tape drive. For decades magnetic tape served as the medium of choice for computing. It was faster than punch cards, and more available than hard drives. But where did it come from? Is it a borrowed technology like the vacuum tube? Like Advent of Computing? Then check out the after show! Adjunct of Computing is now LIVE: YouTube Spotify Apple Podcasts
Send us Fan MailIn this Journal Club episode, Daphna presents the F-NeoBright trial — a pilot feasibility and safety study out of Hungary exploring intranasal fresh breast milk administration in neonates with moderate to severe HIE undergoing therapeutic hypothermia. With so few adjunct therapies available beyond cooling, the idea of harnessing breast milk's rich bioactive components — including neurotrophic growth factors, cytokines, and multipotent stem cells — to support the developing brain is both compelling and refreshingly low-risk. Daphna walks us through the protocol, the feasibility outcomes, and why 100% of approached families consented, including those who had never planned to breastfeed. Sometimes the simplest intervention really is the right one!----F-NEO-BRIGHT: feasibility and safety of intranasal fresh breast milk in neonatal encephalopathy. Tarjanyi E, Jermendy A, Szabo M, Brandt FA, Szasz B, Nyilas N, Meder U.Pediatr Res. 2026 Mar 3. doi: 10.1038/s41390-026-04847-2. Online ahead of print.PMID: 41776367Support the showAs always, feel free to send us questions, comments, or suggestions to our email: nicupodcast@gmail.com. You can also contact the show through Instagram or Twitter, @nicupodcast. Or contact Ben and Daphna directly via their Twitter profiles: @drnicu and @doctordaphnamd. The papers discussed in today's episode are listed and timestamped on the webpage linked below.Enjoy!
Featuring perspectives from Dr Stacey A Cohen, Dr Christopher Lieu and Dr Jenny Seligmann, moderated by Dr Lieu, including the following topics: Adjuvant treatment planning for Stage II or III microsatellite instability-high colon cancer (0:00) Roles of circulating tumor DNA (ctDNA), POLE mutations and advanced age in adjuvant treatment planning (6:08) Role of ctDNA in adjuvant treatment planning for Stage III colon cancer (12:31) CME information and select publications
Featuring perspectives from Dr Haley Ellis, Prof Eric Van Cutsem and Dr Zev Wainberg, moderated by Dr Lionel A Kankeu Fonkoua, including the following topics: Gastroesophageal cancer (0:00) Recurrent colorectal cancer (5:43) Colorectal cancer with brain metastases (9:59) CME information and select publications
In which we discuss GPSS: the General Purpose Simulation Language. As for as languages go, this is a unique one. It's designed for certain types of simulations. It's code is just a handy way to feed a flowchart into a computer. It's design is closer to an analog computer than it is to a programming language. Yet GPSS is Turing Complete. Step inside and prepare to be... confused! The big source of the show: https://dl.acm.org/doi/epdf/10.1145/960118.808382 - The Development of GPSS Like Advent of Computing? Then check out the after show! Adjunct of Computing is now LIVE: YouTube Spotify Apple Podcasts
Featuring perspectives from Dr Jaffer A Ajani, Dr Samuel J Klempner, Dr Rutika Mehta and Dr John Strickler, moderated by Dr Klempner, including the following topics: Older patient with metastatic claudin 18.2-positive gastroesophageal (GE) cancer (0:00) Management of nausea and vomiting with zolbetuximab for GE cancer (9:37) Younger patient with metastatic claudin 18.2-positive, PD-L1-positive GE cancer (15:34) CME information and select publications
Featuring perspectives from Prof Karim Fizazi and Dr Daniel George, moderated by Dr Elisabeth I Heath, including the following topics: Introduction (0:00) Clinical Implications of and Appropriate Strategies to Identify PTEN Deficiency in Prostate Cancer — Dr George (3:25) Targeting AKT in Metastatic Prostate Cancer — Prof Fizazi (32:54) Tolerability and Other Practical Considerations with Capivasertib — Dr Heath (1:03:15) CME information and select publications
What if the secret to thriving in life and business could be learned from the baseball diamond?In this powerful episode of Thrive LouD, Lou Diamond welcomes back acclaimed baseball writer and author Ken Davidoff for an eye-opening conversation about his newest book, "101 Lessons from the Dugout: What Baseball and Softball Can Teach Us About the Game of Life."Fittingly recorded LIVE in studio on Opening Day!!Discover why Ken Davidoff walked away from a 30-year sportswriting career at the top of his game and how a random call from his agent opened the door to a new adventure in teaching, mentoring, and authorship. The episode dives deep into how the life lessons found between the foul lines can impact coaches, parents, leaders, and young athletes alike. Hear the behind-the-scenes stories about crafting the book alongside pediatrician Dr. Harley Rothbard, the power of collaboration, and the surprising writing process that turned daily deadlines into an enjoyable pursuit.You'll also hear Ken Davidoff's Mount Rushmore of greatest games he ever covered (some with national, historic significance), what he misses most about journalism, and, of course, the real-life lesson from the game that changed his approach forever.Episode Timestamps:[00:00] Introduction and welcome[00:42] Ken Davidoff's background in baseball journalism[02:09] Adjunct teaching and career shift[02:41] Why Ken Davidoff left sportswriting and how the book project began[03:23] Blending perspectives: the inspiration behind "101 Lessons from the Dugout"[04:11] Translating baseball lessons to life and the story of the “stretch”[05:44] Who the book is for—players, coaches, parents, leaders[06:47] Pro athletes, leadership, and lessons for players[08:06] Ken Davidoff's writing process and collaboration with his co-author[09:30] Editing the book and feedback process[11:25] Lessons that didn't make the cut[12:03] Promoting the book and leveraging relationships[13:11] What Ken Davidoff misses (and doesn't miss) about journalism[14:42] Is there another book on the way?[15:21] Where to find Ken Davidoff and the book[16:21] Fun Street: favorite sports moments, activities, and lessons[22:13] Ken Davidoff's favorite life lesson: "Small Ball"[23:26] Personal memorabilia and closing thoughts[25:19] Outro and where to connectGet ready to see the game—and life itself—in a whole new way!
Featuring perspectives from Dr Stacey A Cohen, Dr Christopher Lieu and Dr Jenny Seligmann, moderated by Dr Lieu, including the following topics: Neoadjuvant immunotherapy for localized rectal cancer (0:00) Surveillance in neoadjuvant immunotherapy for localized rectal cancer (8:14) Determining a treatment strategy for resectable colon cancer (12:35) CME information and select publications
In part two of this series, Dr. Aaron Zelikovich discusses the clinical implications for patients with HSV encephalitis. Show citation: Solomon T, Hooper C, Easton A, et al. Safety and efficacy of adjunct dexamethasone in adults with herpes simplex virus encephalitis in the UK (DexEnceph): a multicentre, observer-blind, randomised, phase 3, controlled trial. Lancet Neurol. 2026;25(2):136-146. doi:10.1016/S1474-4422(25)00454-5
The Olivetti Programma 101 isn't quite like any other machine. On first glance it looks like a big desktop calculator. Inside, it's a purebred computer... but strange one. It uses twisted spring steel for memory, has no addresses, and it's machine code looks more like a spell than a program. It's existence is due, in no small part, to a man being very mean to GE engineers. Like Advent of Computing? Then check out the after show! Adjunct of Computing is now LIVE: YouTube Spotify Apple Podcasts
In part one of this series, Dr. Aaron Zelikovich discusses the trial design and primary results. Show citation: Solomon T, Hooper C, Easton A, et al. Safety and efficacy of adjunct dexamethasone in adults with herpes simplex virus encephalitis in the UK (DexEnceph): a multicentre, observer-blind, randomised, phase 3, controlled trial. Lancet Neurol. 2026;25(2):136-146. doi:10.1016/S1474-4422(25)00454-5 Show transcript: Dr. Aaron Zelikovich: Welcome to today's Neurology Minute. My name is Aaron Zelikovich. I'm a neuromuscular specialist at Lenox Hill Hospital in New York City. Today, we'll discuss part one of a three-part series reviewing a recent article titled Safety and Efficacy of Adjunct Dexamethasone in Adults with Herpes Simplex Virus Encephalitis in the United Kingdom (DexEnceph) Study, a multicenter observer-blind randomized phase three control trial published in Lancet Neurology. In the first episode, we'll focus on the trial design and primary results. In part two, we'll discuss the clinical implications for patients with HSV encephalitis, and in part three, discuss the outcomes seen across the trial during and after an acute infection. Overall, the study found that adjunct dexamethasone did not improve outcomes in patients with CSF-confirmed HSV encephalitis. But importantly, it also did not worsen outcomes. Prior research that was non-randomized and retrospective of 45 patients with HSV encephalitis found that patients did not receive corticosteroids had worse outcomes. A different randomized trial looking at dexamethasone and HSV encephalitis was only able to recruit 41 patients and was stopped prematurely due to the lack of recruitment. Prior to the study, there was no clear evidence that adjunct steroids with acyclovir improved outcomes in HSV encephalitis. The Dex and phase three randomized clinical trial performed in the United Kingdom at 53 hospitals recruited patients from 2016 to 2022. They screened over 1,400 patients of which only 94, or 6%, were enrolled. Patients were randomized to either acyclovir only or acyclovir and intravenous dexamethasone. In order to be randomized, patients had to have a febrile illness with new onset seizure or new focal neurological sign or altered mental status as well as a positive HSV type one or two PCR from the CSF. The primary outcome for this study was the Wechsler Memory Scale Type Four Auditory Memory Index Score which was collected at 26 weeks. It had a range of 40, which is the worst outcome, to a range of 160 which was considered normal. 81 patients were included in the modified intention-to-treat analysis. Of the 13 patients, six were lost to follow-up, and seven withdrew consent. There were 39 patients in the dexamethasone group and 42 in the acyclovir-only group in the final analysis. The primary outcome of the Wechsler Memory Scale had similar scores in both groups. 71 in the dexamethasone group and 69 in the control group with a P value of 0.76. The safety profile was similar in both groups, and there were no additional safety signals found in the dexamethasone-treated group. At 26 weeks, there were 12 deaths from HSV encephalitis, six from each group, as well as a similar time to discharge between both cohorts. The DexEnceph clinical trial did not show any clear clinical benefit for dexamethasone with regards to clinical outcomes but also didn't show any increased safety concerns compared to only acyclovir. In part two, we will discuss the implications of this trial in patients with undifferentiated encephalitis and the role that steroids play in patients that HSV encephalitis is suspected. Thank you so much, and have a wonderful day.