Podcasts about Neurotoxicity

He reveals how food packaging, seafood, and meat concentrate microplastics and forever chemicals, risking brain and endocrine health. #Microplastics #FoodToxins #BrainHealth #EnvironmentalHealth

Understand how parasites, spike protein, mold, and detox strategies like glutathione and colonics impact cognition and gut-brain health. #ToxinDetox #MoldAwareness #GutBrainAxis #NeuroInflammation

Autism, ADHD, and Alzheimer's rates rise with glyphosate use. Families and doctors report dramatic recovery on organic diets. #AutismRecovery #NeuroHealth #GMOImpact

What if one of the biggest health threats on Earth… is something you can't see, taste, or even fully measure yet? In this urgent solo episode, Darin breaks down the rapidly escalating crisis of microplastics and nanoplastics infiltrating our bodies, water systems, and environment. What was once dismissed is now being acknowledged at the highest levels, with government agencies scrambling to understand and contain the damage. From plastics crossing the blood-brain barrier to disrupting hormones and carrying toxic chemicals deep into human tissue, this episode exposes the hidden cost of modern convenience, and more importantly, gives you practical, immediate actions you can take to protect yourself and your family. What You'll Learn Why microplastics are now considered a global health emergency How plastics accumulate in your body and environment The shocking truth about nanoplastics crossing the blood-brain barrier How plastics act as endocrine disruptors affecting hormones The connection between plastics and inflammation, fertility, and disease Why tap water and bottled water are both major exposure sources The role of PFAS ("forever chemicals") in long-term health damage How to filter and detox microplastics from your body Emerging science on breaking down plastics using bacteria and plants Simple, actionable steps to dramatically reduce your exposure Chapters 00:00:00 – Welcome to SuperLife 00:02:12 – Opening: committing to a clean, conscious life 00:02:27 – Fatal conveniences and why awareness matters 00:02:46 – Government officially flags microplastics as a crisis 00:03:04 – $100M+ initiatives to understand plastic contamination 00:03:38 – Microplastics in drinking water and daily exposure 00:04:20 – Plastics found in babies and human brains 00:04:45 – Why we still don't understand the full damage 00:05:08 – Nanoplastics crossing the blood-brain barrier 00:05:33 – Plastics as endocrine disruptors 00:06:02 – Hormonal imbalance, inflammation, and toxicity 00:06:30 – PFAS and the "forever chemical" crisis 00:06:59 – The #1 rule: stop using single-use plastic bottles 00:07:27 – Hidden dangers of "BPA-free" plastics 00:07:58 – Why you can no longer trust tap water 00:08:30 – The importance of high-quality water filtration 00:09:11 – Reverse osmosis systems and best practices 00:10:17 – Detox strategies: sweating and sauna use 00:10:59 – Fiber and plant-based diets binding toxins 00:11:24 – Medicinal mushrooms and beta glucans 00:11:52 – Microbes that break down plastic polymers 00:12:32 – Plant-based flocculants (okra, fenugreek) removing plastics 00:13:20 – Bio-sponges and advanced filtration innovations 00:13:46 – Magnetic separation technology 00:14:27 – Microplastics from clothing and laundry systems 00:15:16 – AI-assisted filtration and regulatory changes 00:15:55 – Light-activated breakdown of plastics 00:16:03 – Boiling water to remove up to 90% of microplastics 00:16:33 – Practical emergency water filtration methods 00:16:59 – Creating a low-toxicity lifestyle at home 00:17:20 – Final message: take control and protect your health 00:17:32 – Outro     Thank You to Our Sponsors Tru Niagen – Boost NAD+ levels for cellular health and longevity. Get 20% off with code DARIN20 at truniagen.com. Shakeology – Shakeology-All in One Nutrition: Get 15% off with code SUPERLIFE at Shakeology.com.     Join the SuperLife Patreon: This is where Darin now shares the deeper work: - weekly voice notes - ingredient trackers - wellness challenges - extended conversations - community accountability - sovereignty practices Join now for only $7.49/month at https://patreon.com/darinolien     Connect with Darin Olien: Website: darinolien.com Instagram: @darinolien Book: Fatal Conveniences Platform & Products: superlife.com New Show: Roadmap to Happiness     Key Takeaway: "We are living in a world where convenience has quietly introduced toxins into nearly every aspect of our lives, but you are not powerless. The moment you become aware, you can take action. And the small choices you make every day: what you drink from, how you filter your water, what you put into your body, can dramatically shift your long-term health and your family's future."     Bibliography/Sources: The News Hook — EPA CCL6 & STOMP Initiative Chemical & Engineering News. (2026, April 3). US government targets microplastics for research and potential drinking-water regulation. American Chemical Society. https://cen.acs.org Environmental Protection Agency. (2026, April 2). EPA takes bold action to ensure drinking water is safe from microplastics, pharmaceuticals, and potential hidden contaminants [Press release]. https://www.epa.gov/newsreleases Environmental Protection Agency & Department of Health and Human Services. (2026, April 2). EPA, HHS announce historic actions to protect Americans from microplastics and safeguard drinking water [Press release]. https://www.epa.gov/newsreleases Inside Climate News. (2026, April 3). EPA flags microplastics as 'priority' water contaminants, but the move doesn't guarantee regulation. https://insideclimatenews.org National Public Radio. (2026, April 2). EPA flags microplastics, pharmaceuticals as contaminants in drinking water. https://www.npr.org STAT News. (2026, April 2). EPA to put microplastics on study list of contaminants in drinking water. https://www.statnews.com The New Lede. (2026, April 2). EPA flags microplastics as 'priority' contaminants in drinking water. https://thenewlede.org U.S. Government. (2026). Public comment docket: EPA-HQ-OW-2022-0946. https://www.regulations.gov The Science — Brain Invasion & Cellular Damage ACS Environment & Health. (2025). Neurotoxicity of micro- and nanoplastics: A comprehensive review of CNS impacts. American Chemical Society. https://pubs.acs.org Journal of Nanobiotechnology. (2025). Maternal nanoplastic exposure led to impaired neuronal development in the fetal cortex. Springer Nature. PubMed Central. (2023). Micro-/nanoplastics breach the blood-brain barrier: Biomolecular corona's role revealed. National Institutes of Health. https://pmc.ncbi.nlm.nih.gov PubMed Central. (2024). A review on micro- and nanoplastics in humans: Translocation of barriers and potential health effects. National Institutes of Health. https://pubmed.ncbi.nlm.nih.gov PubMed Central. (2025). Overall effects of microplastics on brain. National Institutes of Health. https://pmc.ncbi.nlm.nih.gov ScienceDirect. (2025). Mechanisms of micro- and nanoplastics on blood-brain barrier crossing and neurotoxicity. Elsevier. https://www.sciencedirect.com The Science — Endocrine Disruption & Gut Health eClinicalMedicine. (2026). Phthalates attributed to nearly 2 million preterm births globally. The Lancet. Frontiers in Cellular and Infection Microbiology. (2024). Microplastics, human health, and the gut microbiome. Frontiers. https://www.frontiersin.org Frontiers in Endocrinology. (2023). A review of the endocrine disrupting effects of micro and nano plastic in mammals. Frontiers. International Journal of Molecular Sciences. (2025). Micro- and nanoplastics as disruptors of the endocrine system. MDPI. https://www.mdpi.com PubMed Central. (2025). Microplastics, endocrine disruptors, and oxidative stress. National Institutes of Health. Solutions — Filtration & Global Removal Technologies ACS Applied and Environmental Microbiology. (2024). Eco-microbiology: Discovering biochemical enhancers of PET biodegradation by Piscinibacter sakaiensis. American Chemical Society. ACS Omega. (2025). Thermostability and activity improvements of PETase from Ideonella sakaiensis. American Chemical Society. Environmental Science & Technology Letters. (2024). Drinking boiled tap water reduces human intake of nanoplastics and microplastics. American Chemical Society. https://doi.org/10.1021/acs.estlett.4c00081 Srinivasan, R., et al. (2025). Fenugreek and okra polymers as treatment agents for the removal of microplastics from water sources. ACS Omega. https://doi.org/10.1021/acsomega.4c07476 Yoshida, S., et al. (2016). A bacterium that degrades and assimilates poly(ethylene terephthalate). Science.  

Parents and clinicians are often faced with an important question: is anesthesia safe for young children? In this episode, medical student Kaavya Gudapati is joined by Dr. Maria Valeria Carrasquero and Dr. Ana Mavarez to review the current evidence on anesthesia exposure and the developing brain, and to provide practical guidance for clinical decision-making and family counseling. Specifically, they will: Review the FDA warning regarding repeated or prolonged anesthesia exposure in children under 3 years of age Compare key findings from animal studies and human clinical trials Summarize major studies including PANDA, MASK, and GAS Discuss strategies for counseling families and addressing parental concerns Identify considerations for timing of elective versus urgent procedures Review approaches to minimize exposure and explore potential neuroprotective strategies Special thanks to Dr. Heather Byrd and Dr. Rebecca Yang for peer reviewing this episode. CME available free with sign up: Link coming soon! References: 1. Vinson AE, Houck CS. Neurotoxicity of Anesthesia in Children: Prevention and Treatment. Curr Treat Options Neurol 2018; 20:1–10. https://doi.org/10.1007/S11940-018-0536-Z/TABLES/1. 2. Hansen TG. Anesthesia-related neurotoxicity and the developing animal brain is not a significant problem in children. Pediatric Anesthesia 2015; 25:65–72. https://doi.org/10.1111/PAN.12548. 3. O'Leary JD. Human Studies of Anesthesia-Related Neurotoxicity in Children: A Narrative Review of Recent Additions to the Clinical Literature. Clin Perinatol 2019; 46:637–45. https://doi.org/10.1016/j.clp.2019.08.001. 4. FDA Drug Safety Communication: FDA review results in new warnings about using general anesthetics and sedation drugs in young children and pregnant women | FDA n.d. https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-review-results-new-warnings-about-using-general-anesthetics-and (accessed August 28, 2025). 5. FDA Drug Safety Communication: FDA approves label changes for use of general anesthetic and sedation drugs in young children | FDA n.d. https://www.fda.gov/drugs/drug-safety-and-availability/fda-drug-safety-communication-fda-approves-label-changes-use-general-anesthetic-and-sedation-drugs (accessed August 28, 2025). 6. SmartTots. SmartTots consensus statement on the use of anesthetic and sedative drugs in infants and toddlers.Published 2015. Updated 2017. Accessed September 17, 2025. https://smarttots.org 7. Sun LS, Li G, Miller TLK, Salorio C, Byrne MW, Bellinger DC, et al. Association between a single general anesthesia exposure before age 36 months and neurocognitive outcomes in later childhood. JAMA - Journal of the American Medical Association 2016; 315:2312–20. https://doi.org/10.1001/JAMA.2016.6967. 8. Warner DO, Zaccariello MJ, Katusic SK, Schroeder DR, Hanson AC, Schulte PJ, et al. Neuropsychological and behavioral outcomes after exposure of young children to procedures requiring general anesthesia: The mayo anesthesia safety in kids (MASK) study. Anesthesiology 2018; 129:89–105. https://doi.org/10.1097/ALN.0000000000002232. 9. McCann ME, Berde C, Soriano S, Marmor J, Bellinger D, de Graaff JC, et al. Neurodevelopmental outcome at 5 years of age after general anaesthesia or awake-regional anaesthesia in infancy (GAS): an international, multicenter, randomised controlled equivalence trial. Lancet 2019; 393:664. https://doi.org/10.1016/S0140-6736(18)32485-1. 10. Davidson AJ, Disma N, de Graaff JC, Withington DE, Dorris L, Bell G, et al. Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): An international multicentre, randomised controlled trial. The Lancet 2016; 387:239–50. https://doi.org/10.1016/S0140-6736(15)00608-X. 11. Reighard C, Junaid S, Jackson WM, Arif A, Waddington H, Whitehouse AJO, et al. Anesthetic Exposure During Childhood and Neurodevelopmental Outcomes: A Systematic Review and Meta-analysis. JAMA Netw Open 2022;5: e2217427. https://doi.org/10.1001/JAMANETWORKOPEN.2022.17427. 12. Jadhav U, Bhanushali J, Sindhu A, Shiv Kiran Reddy B, Toshniwal A, Rashmika M. A Comprehensive Review of Pediatric Obstructive Sleep Apnea: From Assessment to Intervention 2025. https://doi.org/10.7759/cureus.78051. 13. Andropoulos DB. Neuroprotective strategies in anesthesia-induced neurotoxicity. Best Pract Res Clin Anaesthesiol 2023; 37:52–62. https://doi.org/10.1016/J.BPA.2022.11.005. 14. Ji F, Sun J, Sun L, et al. Effects of Dexmedetomidine and Remifentanil on Neurodevelopmental Outcomes After Sevoflurane Anesthesia in Infants: A Randomized Clinical Trial. Anesthesiology. 2025. 143(4), 827–834. https://doi.org/10.1097/ALN.0000000000005634 15. Saynhalath, R, Disma, N, Taverner, FJ et al. on behalf of the TREX (Trial Remifentanil DEXmedetomidine) Consortium. Short-term Outcomes in Infants after General Anesthesia with Low-dose Sevoflurane/Dexmedetomidine/Remifentanil versus Standard-dose Sevoflurane (the TREX Trial). Anesthesiology 141(6): p 1075-1085, December 2024. | DOI: 10.1097/ALN.0000000000005232 16. Ing C, Warner DO, Sun LS, Flick RP, Davidson AJ, Vutskits L, McCann ME, O'Leary J, Bellinger DC, Rauh V, Orser BA, Suresh S, Andropoulos DB. Anesthesia and Developing Brains: Unanswered Questions and Proposed Paths Forward. Anesthesiology. 2022 Mar 1;136(3):500-512. doi: 10.1097/ALN.0000000000004116. PMID: 35015802.

EPA experts admit neurotoxicity at doses near 2ppm, with common U.S. exposures far above safe margins. #ToxicLevels #NeuroSafety #EPAConcession #FluorideLimit

In this heartfelt and wide-ranging episode, host Bryan reconnects with Jim Bergmann of measureQuick after nearly three years apart. The reunion is anything but ordinary — Jim opens up about a serious battle with non-Hodgkin's B-cell lymphoma that sent him through not one but two rounds of chemotherapy, ultimately requiring a cutting-edge CAR-T cell immunotherapy treatment at the Cleveland Clinic. Jim shares the remarkable medical journey of having his T cells extracted, genetically modified in a Maryland lab, and reintroduced into his body to permanently attack cancer cells. Now past the critical six-month remission milestone, Jim is back, healthy, and more motivated than ever to push the HVAC diagnostics industry forward. From his medical comeback, the conversation transitions naturally into what Jim loves most: the world of HVAC diagnostics and the evolution of measureQuick. After years of defending a per-use pricing model that the market simply didn't embrace, Jim candidly admits the old model wasn't working. With the help of business partner Eric Preston (formerly of TruTech Tools), the team overhauled the software's pricing structure in February — a move that has since driven 90%+ customer retention and accelerated growth significantly. The new focus is squarely on "time to value," streamlining workflows so technicians reach key diagnostic reports faster than ever before. A significant portion of the episode dives into how measureQuick is thoughtfully integrating artificial intelligence. Rather than chasing AI trends, Jim and his team — including AI specialist Ben Reed — took a deliberate approach: identifying the precise areas where AI genuinely helps technicians without creating distractions. The standout use case is label identification, where AI reads equipment labels and auto-populates system profiles. Jim is refreshingly candid about AI's limitations in HVAC diagnostics, explaining that the field variability of real-world systems (varying line set lengths, mismatched equipment, non-standard airflow conditions) makes purely AI-driven diagnostics unreliable. Instead, measureQuick leans on first-principle modeling and non-dimensional mathematics to generate objective, data-driven results. The episode closes with a thought-provoking discussion about the state of the HVAC industry at large. Bryan and Jim tackle the growing influence of private equity consolidation, the persistent problem of technicians skipping probe deployment, the difference between clearing faults and actually fixing them, and the importance of commissioning and retro-commissioning equipment to manufacturer design intent. Throughout it all, the conversation is anchored by a shared belief: that measuring everything — in business and on the job — is the foundation of genuine, lasting improvement. It's a must-listen for any HVAC professional or business owner who wants to understand where the industry is headed. Topics Covered Jim's cancer diagnosis: non-Hodgkin's B-cell lymphoma and the progression from standard chemo to aggressive relapse CAR-T cell immunotherapy explained: how T cells are extracted, genetically modified, and reintroduced to fight cancer permanently Jim's recovery at the Cleveland Clinic and surpassing the critical six-month remission milestone Neurotoxicity as a side effect of CAR-T therapy and what that experience was like The pivot away from measureQuick's per-use pricing model and the dramatic improvement in retention after switching The "time to value" philosophy driving measureQuick's new hybrid workflow interface How measureQuick is integrating AI — and where AI falls short in real-world HVAC diagnostics Label identification as the most practical current AI application in field diagnostics Why AI is highly sycophantic and the danger of relying on subjective, internet-sourced training data for HVAC decisions The power of measureQuick's proprietary measurement data and target zones as a foundation for AI summaries First-principle modeling and non-dimensional mathematics: why brand-agnostic diagnostics work The importance of deploying all nine probes on every air conditioning service call Benchmarking vs. commissioning vs. retro-commissioning: the three layers of equipment assessment Design temperature difference: measuring evaporator and condenser delta-T as engineering benchmarks How ECM motors mask airflow problems — and why that leads to premature motor failure and higher energy costs The two "elephants in the room": incomplete probe deployment and clearing faults without fixing them Why clearing a fault in measureQuick without addressing the root cause is like putting duct tape over a check engine light How poor installation practices in high-growth markets (Florida, Texas, Arizona, Las Vegas) have created widespread system deficiencies The role of private equity in HVAC consolidation and why many PE firms add cost without adding value Why implementing field measurement systems like measureQuick is the missing link for PE-owned and independent shops alike The legacy mode vs. new mode toggle in the upcoming measureQuick update — no forced UI changes for existing users How measureQuick helps newer technicians become productive faster and helps seasoned technicians be more consistent The importance of presenting diagnostic findings to homeowners and helping them understand what the numbers actually mean   Learn more about measureQuick at https://measurequick.com/.  Have a question that you want us to answer on the podcast? Submit your questions at https://www.speakpipe.com/hvacschool. Purchase your tickets or learn more about the 7th Annual HVACR Training Symposium at https://hvacrschool.com/symposium. Subscribe to our podcast on your iPhone or Android. Subscribe to our YouTube channel. Check out our handy calculators here or on the HVAC School Mobile App for Apple and Android.

Internal admissions from CDC and EPA show agreement with findings that fluoride causes brain damage in animal studies. #FluorideRisk #CDCAdmissions #Neurodamage #BrainToxins

Wireless tech wasn't tested for long-term safety. Learn how EMFs disrupt your biology and why “non-ionizing” doesn't mean harmless. #EMFHealth #WirelessRisks #CellRadiation #HealthTalks

Honeycutt reveals how glyphosate contaminates crops, animal feed, and vaccines—posing long-term risks to immune and neurological health. #GlyphosateExposure #ToxicFood #HealthRisk

Understanding and Treating Complex Illnesses with Dr. Neil Nathan, author of “Toxic 2nd Edition: Heal Your Body from Mold Toxicity, Lyme Disease, Multiple Chemical Sensitivities, and Chronic Environmental Illness.” Dr. Nathan shares his expertise on the multifaceted nature of chronic illnesses, which often defy simple categorization and may be misdiagnosed as psychiatric issues. The discussion covers the impact of environmental toxins, electromagnetic fields, and infections like Lyme disease and long COVID. Dr. Nathan also highlights the importance of understanding inflammation's complex pathways and offers suggestions for both elimination of root causes and restoration of immune system functionality. The episode provides insights into new diagnostic tools and treatment methodologies for persistent and intrusive health issues.

Dr. Alison Christy and Dr. Jennifer L. McGuire discuss neuroimaging findings linked to ICANS, exploring whether specific imaging patterns correlate with distinct neurologic symptoms.  Show citation:  McGuire JL, Pinto S, Erdogan EN, et al. Neuroimaging Findings in Children and Young Adults With Neurotoxicity After CAR T-Cell Therapy for B-Cell Malignancies. Neurology. 2025;105(7):e214086. doi:10.1212/WNL.0000000000214086 

Dr. Alison Christy and Dr. Jennifer L. McGuire discuss neuroimaging findings linked to ICANS, exploring whether specific imaging patterns correlate with distinct neurologic symptoms.  Show citation:  McGuire JL, Pinto S, Erdogan EN, et al. Neuroimaging Findings in Children and Young Adults With Neurotoxicity After CAR T-Cell Therapy for B-Cell Malignancies. Neurology. 2025;105(7):e214086. doi:10.1212/WNL.0000000000214086 

Dr. Alison Christy talks with Dr. Jennifer L. McGuire about neuroimaging findings linked to ICANS, exploring whether specific imaging patterns correlate with distinct neurologic symptoms.  Read the related article in Neurology®.  Disclosures can be found at Neurology.org.  

Featuring an interview with Dr Beth Faiman, including the following topics: Clinical practice background and historical view of treatment for multiple myeloma (MM) (0:00) Fundamental principles associated with chimeric antigen receptor (CAR) T-cell therapy (7:19) Sequencing of CAR T-cell therapy and bispecific antibodies in the MM treatment landscape (9:00) Patient eligibility to receive CAR T-cell therapy (13:23) Differentiating among approved CAR T-cell therapies for MM (18:18) Durability of responses to CAR T-cell therapy for MM (24:01) Neurotoxicity with CAR T-cell therapies for MM (26:26) Minimal residual disease monitoring in MM (29:39) Support systems for the management of toxicities associated with CAR T-cell therapy (35:10) Patients with MM experiencing durable responses to CAR T-cell therapy (43:11) NCPD information and select publications

Most people think electroshock therapy was abandoned decades ago. The unfortunate truth is it's still widely used, with well over 100,000 (probably much higher) Americans receiving ECT every year.Yet the devices have never been properly safety tested.In this episode, Dr. Roger McFillin sits down with Sarah Price Hancock, a certified rehabilitation counselor, educator, and survivor who underwent 116 ECT treatments. Sarah lost 85–90% of her memories from the first 36 years of her life, developed neurological complications, and later learned her original psychiatric symptoms weren't even a mental illness.Life After ECT website Dr. Roger McFillin / Radically Genuine WebsiteYouTube @RadicallyGenuineDr. Roger McFillin (@DrMcFillin) / XSubstack | Radically Genuine | Dr. Roger McFillinInstagram @radicallygenuineContact Radically GenuineConscious Clinician CollectivePLEASE SUPPORT OUR PARTNERS15% Off Pure Spectrum CBD (Code: RadicallyGenuine)10% off Lovetuner click here

The growing spectrum of neurotoxicities related to targeted cancer therapies can present a challenge for radiologists. In this AJR Conversation, Neuroradiology Imaging Senior Editor Carlos Zamora, MD, PhD, speaks with Alvand Hasankhani, MD, about his team's recently published article addressing the critical role of neuroimaging in detecting and differentiating neurotoxicity syndromes associated with common and emerging cancer therapies.

In this episode of ASTCT Talks, Dr. Rahul Banerjee sits down with Dr. Kenneth Lim and Dr. Yi Lin of Mayo Clinic to discuss a critical and emerging topic in CAR T-cell therapy: delayed neurotoxicities following cilta-cel treatment in multiple myeloma. They break down the clinical features of nerve palsies and Parkinsonism-like symptoms, share diagnostic and treatment strategies and explore emerging predictive markers like absolute lymphocyte count. Given that cilta-cel is increasingly being used in second-line myeloma treatment and is even being studied in first-line treatment to replace stem cell transplantation, this conversation is a timely and insightful look at improving patient outcomes in CAR T-cell therapy.

In this week's episode, we'll learn more about the identification and characterization of stem cell-like leukemia blasts using single cell multi-omics, cyclophosphamide as a treatment for non-immune effector cell-associated neurotoxicity in patients treated with B-cell maturation antigen, or BCMA, targeted CAR T-cell therapies, and how differences in glycosylation affect the clearance of human plasma-derived and recombinant von Willebrand factor concentrates.Featured Articles:Single-cell panleukemia signatures of HSPC-like blasts predict drug response and clinical outcomeCyclophosphamide mitigates non-ICANS neurotoxicities following ciltacabtagene autoleucel treatmentEnhanced α2-3–linked sialylation determines the extended half-life of CHO-rVWF

Heavy Metals and Mineral Deficiencies: Their Link to Migraines. In this episode of Intelligent Medicine, Nutritionist Leyla Muedin discusses the correlation between heavy metals, trace mineral deficiencies, and migraines. Recent studies from researchers in the Netherlands and Turkey highlight significantly higher levels of lead and cobalt, and lower levels of zinc and selenium in migraine sufferers compared to healthy controls. Leyla explains the impact of neurotoxicity, oxidative stress, hormonal disruption, and impaired detoxification pathways on migraines. She also explores the benefits of zinc and selenium supplementation in reducing the frequency and severity of migraines. Overall, the episode underscores the importance of addressing mineral imbalances and toxic metal exposures in migraine management.

In this episode, we talk with Dr. Hassan Alkhateeb, a hematologist from the Mayo Clinic Transplant Center, about CAR T-cell therapy. Dr. Alkhateeb walks us through the basics of this groundbreaking immunotherapy and how it has evolved as a treatment option for various cancers. CAR T-cell therapy involves collecting a patient's T cells and re-engineering them in the lab to target and destroy cancer cells. This therapy has shown promise in treating blood cancers like B-cell acute lymphoblastic leukemia (ALL), non-Hodgkin lymphoma, multiple myeloma, and even solid tumors like synovial sarcoma.The origins of CAR T therapy date back to 2011, with the first FDA-approved product arriving in 2017. Since then, the therapy has rapidly expanded to treat more conditions. Dr. Alkhateeb explains that while CAR T is often seen as a last-resort treatment, especially in cases where patients have not responded to other therapies, early referral to CAR T specialists is becoming more common. This shift can improve outcomes, as earlier intervention allows for better preparation and potentially more effective treatment.He outlines the evaluation process for CAR T therapy, which is similar to that for bone marrow transplants but focuses on assessing the patient's overall health and suitability for cell collection rather than matching a donor. The cells are then modified in a lab, a process that typically takes two to three weeks. Dr. Alkhateeb notes that manufacturing failures are rare, affecting about 3% of cases.Post-treatment, patients must be monitored closely for side effects such as drops in blood counts, risk of infections, and specific complications like cytokine release syndrome (CRS) and neurotoxicity. These side effects can be severe but are generally manageable with the right care. Caregivers play a crucial role in this process, especially since patients need to stay near the treatment center for an extended period.Dr. Alkhateeb also shares inspiring success stories, including one patient with a particularly challenging form of leukemia who achieved remission and is now back to living a normal life. This highlights the life-saving potential of CAR T therapy and its impact on patients who otherwise have limited options.As we conclude, Dr. Alkhateeb emphasizes the importance of early referrals to specialized centers with experience in CAR T therapy. He expresses optimism about the future of cancer treatment, noting that advancements in this field are providing new hope for patients and their families. We are grateful for his insights and encourage listeners to stay informed about emerging therapies like CAR T, which are transforming the landscape of cancer care.Links:Mayo Clinic Transplant Center: https://www.mayoclinic.org/departments-centers/transplant-centerCAR T-Cell Therapy Information: https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/car-t-cellFDA Approval Information on CAR T Therapies: https://www.fda.gov/news-events/press-announcements/fda-approves-first-car-t-cell-therapyThis season is made possible thanks to our sponsors:Kite, a Gilead company: http://www.kitepharma.com/and Bristol Myers Squibb's CAR T support services program:https://www.celltherapy360.com/ Follow the nbmtLINK on Instagram! https://www.instagram.com/nbmtlink/Or visit our website at https://www.nbmtlink.org/

In this episode of Marrow Masters, we hear the journey of married couple Dave and Laurie Brock, as they share their experience with CAR T-cell therapy— one Dave very recently underwent. The Brocks provide an inspiring and honest account of navigating this complex treatment process. Dave, diagnosed with multiple myeloma in 2015, had an eight-year remission following a stem cell transplant. When he relapsed earlier this year, his doctor, Dr. Abdullah at the University of Kansas Medical Center, recommended CAR T-cell therapy, which had just been FDA-approved for patients in his position. Dave recalls his surprise that what once felt like a “futuristic” option was now available and could be pursued immediately.As Dave began CAR T- cell therapy, he leaned on advice he received early in his treatment: maintain a positive attitude, be informed, and work closely with his healthcare team. Physical fitness played a crucial role in his journey, allowing him to hike and stay active, which he believes aided his recovery. However, the therapy wasn't without challenges. He experienced significant fatigue, developed Bell's palsy as a side effect, and had to constantly monitor for signs of neurotoxicity.Laurie  is Dave's "care partner," not "care giver." And she describes the intensive nature of navigating CAR T- cell therapy. She monitored Dave around the clock, prepared their home with stringent health protocols, and managed the complexities of his medication and appointments. Laurie's commitment required self-sacrifice; she isolated from family and even stopped going to the gym to protect Dave from exposure to illness. However, she also found unexpected joy in the time spent alone with Dave, as they grew closer through shared activities and humor.Both Dave and Laurie emphasize gratitude—appreciating their medical team, the support of their community, and the positive outcomes of CAR T-cell therapy. Their care team was deeply invested in their success, with doctors even celebrating with them on day 31 when test results confirmed Dave was in remission. Dave reflects on how fortunate he feels for his proximity to the clinic and his medical staff's expertise, acknowledging the importance of clinical trials and the contributions of previous patients in advancing treatments like CAR T.The episode closes with Dave's reminder: we're all in this together, underscoring the value of community, support systems, and the role that clinical trials play in the ongoing advancements in cancer treatment.  He also shares his gratitude for anyone who's participated in a clinical trial.  Without them, he wouldn't have had the opportunity to undergo this cutting-edge treatment. This season is made possible thanks to our sponsors:Kite, a Gilead company: http://www.kitepharma.com/and Bristol Myers Squibb's CAR T support services program:https://www.celltherapy360.com/ Follow the nbmtLINK on Instagram! https://www.instagram.com/nbmtlink/Or visit our website at https://www.nbmtlink.org/

Become a member, FREE for 30 days! https://hayliepomroy.com/member   What if the toxins in your everyday life were silently impacting your brain health? In this episode, I'm excited to talk with Dr. Gordon Crozier, an osteopathic doctor and expert in neurotoxicity. Recognized for his compassionate approach and honored with the Most Compassionate Doctor award, Dr. Crozier offers valuable insights into how toxins impact our brain and overall health. We also explore the critical role of personalized, compassionate care and the promising future of peptide therapy. Dr. Crozier emphasizes that it's never too late to take control of your health and that small, consistent steps can lead to significant improvements. Gain valuable insights on how to advocate for your health, understand the importance of empathy in healthcare, and learn about the latest advancements that could change the future of medicine.   Tune in to the Fast Metabolism Matters Podcast – Neurotoxicity Explained with Dr. Gordon Crozier.   Enjoy this episode? Subscribe to Fast Metabolism Matters and leave a 5-star review.   Get a free supplement and nutrition program today. https://hayliepomroy.com/podcast   Sign up for the 10-Day Cleanse Challenge here! https://hayliepomroy.com/cleanse    Get a FREE hard copy of the Fast Metabolism Diet book! https://hayliepomroy.com/freebook   Become a certified Fast Metabolism Health Coach NOW! https://hayliepomroy.com/fmdc   Dr. Gordon Crozier, a Doctor of Osteopathic Medicine from Des Moines University, spent over twenty years in Obstetrics and Gynecology. He's known for his compassionate care, receiving multiple awards including "Most Compassionate Doctor" and recognition as a leading Obstetrician and Gynecologist. Recently honored as "Clinician of the Year" by the International Brain Research for his work in neurotoxicity and neurodegenerative diseases, Dr. Crozier also pursued advanced integrative medicine training and mastery in Peptides. At Crozier Clinic, he specializes in biotoxin illness, autoimmune disorders, and chronic diseases, focusing on personalized, holistic care.   Instagram: https://www.instagram.com/drgordoncrozier?igsh=MWhveGMwOGd6Nm1rZA== LinkedIn: https://www.linkedin.com/in/drcrozier/ YouTube: https://www.youtube.com/@dr.gordoncrozier8325 Website: https://crozierclinic.com/   #Neurotoxicity #BrainHealth #ToxinFree #OsteopathicMedicine #HolisticHealth #WellnessJourney #Detoxify #ProtectYourHealth #Neurotoxicology #COVID #CompassionateHealthcare #Peptides #HealthPodcast #CompassionateCare  

Become a member, FREE for 30 days! https://hayliepomroy.com/member   What if the toxins in your everyday life were silently impacting your brain health? In this episode, I'm excited to talk with Dr. Gordon Crozier, an osteopathic doctor and expert in neurotoxicity. Recognized for his compassionate approach and honored with the Most Compassionate Doctor award, Dr. Crozier offers valuable insights into how toxins impact our brain and overall health. We also explore the critical role of personalized, compassionate care and the promising future of peptide therapy. Dr. Crozier emphasizes that it's never too late to take control of your health and that small, consistent steps can lead to significant improvements. Gain valuable insights on how to advocate for your health, understand the importance of empathy in healthcare, and learn about the latest advancements that could change the future of medicine.   Tune in to the Fast Metabolism Matters Podcast – Neurotoxicity Explained with Dr. Gordon Crozier.   Enjoy this episode? Subscribe to Fast Metabolism Matters and leave a 5-star review.   Get a free supplement and nutrition program today. https://hayliepomroy.com/podcast   Sign up for the 10-Day Cleanse Challenge here! https://hayliepomroy.com/cleanse    Get a FREE hard copy of the Fast Metabolism Diet book! https://hayliepomroy.com/freebook   Become a certified Fast Metabolism Health Coach NOW! https://hayliepomroy.com/fmdc   Dr. Gordon Crozier, a Doctor of Osteopathic Medicine from Des Moines University, spent over twenty years in Obstetrics and Gynecology. He's known for his compassionate care, receiving multiple awards including "Most Compassionate Doctor" and recognition as a leading Obstetrician and Gynecologist. Recently honored as "Clinician of the Year" by the International Brain Research for his work in neurotoxicity and neurodegenerative diseases, Dr. Crozier also pursued advanced integrative medicine training and mastery in Peptides. At Crozier Clinic, he specializes in biotoxin illness, autoimmune disorders, and chronic diseases, focusing on personalized, holistic care.   Instagram: https://www.instagram.com/drgordoncrozier?igsh=MWhveGMwOGd6Nm1rZA== LinkedIn: https://www.linkedin.com/in/drcrozier/ YouTube: https://www.youtube.com/@dr.gordoncrozier8325 Website: https://crozierclinic.com/   #Neurotoxicity #BrainHealth #ToxinFree #OsteopathicMedicine #HolisticHealth #WellnessJourney #Detoxify #ProtectYourHealth #Neurotoxicology #COVID #CompassionateHealthcare #Peptides #HealthPodcast #CompassionateCare  

In this week's podcast, Neurology Today's editor-in-chief highlights a new workgroup's recommendations on biomarkers for diagnosing Alzheimer's, AI's ability to track Parkinson's severity from brief videos, and the latest research on how racism leads to neural changes and accelerated aging.

In this bonus episode Ryan highlights some of the great episodes done in 2023 and compiles ALL of the stump the toxicologist segments from 2023 into one easy to consume episode. Test your toxicology differential skills with more than six poisoning cases. Check out the actual episodes for more information in the show notes on each of the poisonings. 

Featuring perspectives from Dr John N Allan, Dr Brad S Kahl, Ms Robin Klebig and Ms Mollie Moran, including the following topics: Introduction (0:00) First-Line Therapy for Chronic Lymphocytic Leukemia (CLL) (11:44) The Impact of Comorbid Conditions on the Choice of First-Line Therapy for Newly Diagnosed CLL (18:08) Toxicities and Other Practical Considerations with Venetoclax-Based Treatment (25:17) The Selection and Sequencing of Therapies for Relapsed/Refractory CLL (35:45) The Tolerability of Available Bruton Tyrosine Kinase (BTK) Inhibitors (40:43) The Potential Role of Therapy Combining BTK Inhibitors and Venetoclax (48:48) Bispecific Antibodies as a Treatment Option for Non-Hodgkin Lymphoma (1:04:19) Cytokine Release Syndrome and Neurotoxicity with Bispecific Antibodies (1:06:25) Other Tolerability and Toxicity Issues with Bispecific Antibody Therapy (1:10:44) Bispecific Antibodies for the Management of Follicular Lymphoma (1:18:19) The Role of Bispecific Antibody Therapy in the Treatment of Diffuse Large B-Cell Lymphoma (1:24:17) Other Practical Considerations with the Use of Bispecific Antibodies (1:40:59) NCPD information and select publications

The impact of heavy metals and ultra-processed foods on cognitive decline is a serious public health issue backed by extensive scientific research. By understanding the sources, mechanisms, preventive measures, and detoxification methods, we can take steps to protect our brain health and advocate for a cleaner, safer environment.Heavy metals, such as lead, mercury, arsenic, and cadmium, are naturally occurring elements found in the Earth's crust. While some, like iron and zinc, are essential for biological functions in trace amounts, others are purely toxic. These metals can enter our bodies through various pathways—contaminated food and water, industrial emissions, and even household products. In addition to heavy metals, the consumption of ultra-processed foods has also been linked to cognitive decline. Ultra-processed foods are characterized by their high content of sugar, unhealthy fats, salt, and artificial additives. A study published in the journal Neurology has shown that diets high in ultra-processed foods are associated with an increased risk of cognitive impairment.The study found that individuals who consumed the highest amounts of ultra-processed foods had a 28% faster rate of cognitive decline compared to those who consumed the least. These foods can cause inflammation and oxidative stress in the brain, similar to the effects of heavy metals. This inflammation and stress can lead to damage in brain areas involved in learning, memory, and executive function.Key Findings:Inflammation: Ultra-processed foods can promote systemic inflammation, which affects brain health. Chronic inflammation is a known risk factor for neurodegenerative diseases like Alzheimer's and dementia.Oxidative Stress: The high levels of refined sugars and unhealthy fats in ultra-processed foods can increase oxidative stress in the brain, leading to neuronal damage and cognitive decline.Nutrient Deficiency: These foods often lack essential nutrients necessary for brain health, such as omega-3 fatty acids, vitamins, and minerals, which are crucial for maintaining cognitive function.Sign up to Noa's NEW 360 Wellness course and receive a 15% coupon code when you mention Raising the New Earth Podcast! Click the link here: https://naturallynoa.com/coursesWe thrive in community - and we'd love you to be part of ours!Join the conversation @raisingthenewearth on IG , YouTube- or all other podcast platforms and learn more at www.raisingthenewearth.comDISCLAIMER: By watching/listening to this post including but not limited to video, text, reel, audio, (“Post”) you understand and agree to the following: This Post is for General information purposes ONLY. We are not liable for any loss, death, property damage, or bodily injury, based on your use or interpretation of the information in this Post. This Post should not be construed as a promise of benefits, a claim of cures, or a guarantee of results to be achieved.

DNS 221 Dave Crosland & Scott McNally react to Jesse James West interviewing Dave, then knock out your listener questions! TIME STAMPS BELOW

In this episode, Dr. Jill sits down with esteemed neurologist, Dr. Raymond Singer, to discuss an important topic that affects us all - protecting our brains from neurotoxins. Our brains play a critical role in our everyday lives, influencing our memory, concentration, reaction time, sleep, thinking, and even language abilities. However, due to various factors such as environmental pollutants, certain medications, and even everyday household products, our brains can be exposed to neurotoxins that can negatively impact their functions. Key Points ✅ Neurotoxicity is a cause of brain damage. Common symptoms can include problems with memory, concentration, reaction time, sleep, thinking, language, as well as depression, confusion, personality changes, fatigue, and numbness of the hands and feet. Many types of nervous system disorders could be caused by neurotoxicity, including numerous neurologic and psychiatric disorders. ✅ Applied neurotoxicology is a cross disciplinary study, requiring training, education, or experience in both toxicology and neuropsychology. An understanding of applied neurotoxicology is necessary for the correct diagnosis and treatment of neurotoxicity. Dr. Raymond Singer Dr. Raymond Singer is a board-certified forensic neuropsychologist, specializing in neurotoxicology. He has testified in several groundbreaking litigation cases, expanding the rights of people to get compensation for neuropsychological injuries from neurotoxic chemicals. He served as an expert witness in the landmark agentWitness in the landmark Agent Orange Vietnam Veterans Litigation, which resulted in the largest settlement at that time for toxic chemical injuries. He recently was featured in an opinion by the United States Supreme Court.

In this episode of The Lisa Ann Experience, join host Lisa Ann as she dives into the world of water fluoridation with the insightful Brenda Staudenmaier. Brenda, one of the driving forces behind the lawsuit you can follow online at FluorideLawsuit.com which shares groundbreaking information about the harmful effects of fluoride in our drinking water.Get ready for an eye-opening conversation as Brenda Staudenmaier uncovers the hidden truths and controversies surrounding water fluoridation. Learn about the research, the stories, and the questions that the documentary brings to light. Whether you're a concerned citizen or simply curious about the impact of fluoride on our health, this episode is a must-listen.Tune in for a thought-provoking exploration of 'Fluoride on Trial' and gain valuable insights into a topic that affects us all. The Lisa Ann Experience brings you another compelling episode that goes beyond the surface, delivering knowledge and awareness to empower you in making informed decisions about your water consumption.The episode closes with the help of curious listeners with the Ask Lisa Ann mailbag. - Follow Lisa Ann: https://thereallisaann.social Follow Ticket Rev: https://twitter.com/TicketRev https://instagram.com/ticketrev https://tiktok.com/@ticketrev https://twitter.com/ticketrev

References Nat Commun. 2022; 13: 4435. Nat Commun 2020; 11: 35 Hayward, J. 1971. "You Can Never Go Home" Moody Blues. https://youtu.be/mUhboF8d1x0?si=IX4iP_W0f3uR65qo Jagger, Richards, Oldham. 1964. "As Tears Go By". Marianne Faithful. https://youtu.be/S8EykQaZ8CU?si=X42TiNsveR7rwdHB --- Send in a voice message: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/message Support this podcast: https://podcasters.spotify.com/pod/show/dr-daniel-j-guerra/support

Today I'm speaking with Dr. Pompa, a doctor who specializes in cellular detox.  We discuss his personal health struggles and how they inspired him to create his thriving practice. We also dive deep into the importance of finding the root cause for your symptoms, addressing hormone resistance, and what harmful oils you should be avoiding in your diet. "When you remove the cause, you can watch all of a sudden the body just start this healing process that it was unable to do."   In this episode, you will learn the following:   The importance of addressing the root cause of health issues Dr. Pompa's five-step approach to fixing the cell The limitations of certain tests and treatments in functional medicine The detrimental effects of vegetable and canola oil on health   Links and Resources Join FASTer Way at www.fasterwaytofatloss.com Don't forget to check out fasterwayshop.com Follow Amanda on Instagram: https://www.instagram.com/amandatress Connect with Dr. Pompa: https://drpompa.com/ Watch Dr. Pompa's webinar: https://pompaprogram.com/

In episode 60 of the Summits Podcast, Vince Todd, Jr. is joined by Dr. Jenny Belsky of Riley Hospital for Children. Tune in as Dr. Belsky shares her research on decreasing the detrimental side effects children and teens experience while receiving cancer therapy, now funded by the Heroes Foundation Team JOEY fund. For more on Dr. Belsky's research, visit https://www.heroesfoundation.org/pediatric-cancer-researcher-will-use-30k-from-team-joey-to-make-patient-journeys-less-painful/. Subscribe to the audio version of the Summits Podcast https://summitspodcast.fireside.fm Find out more about the Heroes Foundation https://www.heroesfoundation.org Find out more about The Brookfield Group https://thebrookfieldgroup.com Discover Platform 24 co-working https://www.platform24.co What's your cancer story? Hosted by cancer survivor and philanthropist Vince Todd, Jr., Chairman and Co-Founder of the Heroes Foundation, and Heroes Foundation Board Member Daniel Abdallah, the Summits Podcast is a place for people to share their stories. Everyone has a cancer story. From battling a deadly disease to caring for a loved one, when we rise up and face life's greatest challenges, we see with a new vision, feel with a greater passion, and think with a deeper perspective. Along the way, paths cross, journeys intersect, and missions converge. For Vince Todd, it was his own cancer diagnosis that led him and his wife, Cindy, to launch the Heroes Foundation to provide meaningful support to cancer patients, education to promote cancer prevention, and resources to advance research for a cure. What started with friends and family grew into a community. The Summits Podcast is an extension of that community. Our stories are what bring us together. Artists, athletes, doctors, business people - we're all family members, community leaders, and activists. Everyone has a story. Anyone can inspire. No one battles alone. Join the conversation. Let's climb the summit together.

Star fruit contains a neurotoxin known as caramboxin that can cause irreversible brain damage at high enough doses.

Join the Benzodiazepine Survey Research Team for a lively roundtable discussion about their research, the findings from the survey, and their latest paper which formally introduces the term benzodiazepine-induced neurological dysfunction, or BIND. Benzodiazepine use and discontinuation are associated with nervous system injury and negative life effects that continue after discontinuation, according to the article “Long-term consequences of benzodiazepine-induced neurological dysfunction: A survey” published June 29, 2023, in the open access journal PLOS ONE.The research team in attendance includes A. J. Reid Finlayson, MD, D E Foster, BA, Christy Huff, MD, Peter R. Martin, MD, MSc, and Alexis D. Ritvo, MD, MPH, along with moderator Angela Peacock, MSW.CHAPTERS00:00 Introductions (Peacock)06:02 Where It All Started (Huff)07:27 Intro to the 3rd Paper (Ritvo) 09:15 Recognizing BIND Differentiation (Foster)09:51 Is Withdrawal and BIND Different? (Martin)12:00 Limitations and Research (Finlayson)13:32 Delphic Process for Determining BIND (Ritvo) 16:23 Appropriateness of the Term BIND (Finlayson) 16:44 BIND Definition (Ritvo)17:18 Neuroadaptation & Neurotoxicity (Martin)20:40 Adverse Life Events (Ritvo) 22:22 What's Next for the Team? (Martin)24:45 What About Other Psych Drugs? (Ritvo)28:12 Any New Research Projects? (Foster) 28:44 Narrative Study of Benzo Buddies (Huff)29:22  Scoping Literature Review on Long-Term Benzo Effects (Ritvo)30:35 Overuse, Effectiveness, & Mental Health (Finlayson)32:17 Toxicity of Benzodiazepines (Martin) 34:54 Confusing for Doctors Too (Martin)36:11 Most Symptoms Are New (Martin)37:44 Large Data Analysis (Finlayson) 38:04 Any Research on Actual Neurology (Martin)38:55 Important to Narrow Down Symptoms of BIND (Finlayson) 39:17 Long Term Effects of Benzos & Other Psych Drugs (Finlayson)41:31 Neurotoxicity & Hope / People Do Heal (Foster)42:41 People Do Heal / She Is Healed (Huff)43:18 Connections with Others (Finlayson)45:16 It's Hard on Doctors Too (Martin)49:40 Marathon Not a Sprint (Ritvo)51:47 That's a Wrap (Peacock)52:22 Acknowledgments (Foster)REFERENCESNEW PUBLICATION (3rd Paper / Focus of Roundtable)— Ritvo A, Foster DE, Finlayson R, Silvernail B, Martin P. Long-term consequences of benzodiazepine-induced neurological dysfunction: A Survey. PLOS ONE. June 29, 2023. https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0285584. OTHER PUBLICATIONS ON THE BENZODIAZPINE SURVEY OF 2018/2019— Reid Finlayson AJ, Macoubrie J, Huff C, Foster DE, Martin PR. Experiences with benzodiazepine use, tapering, and discontinuation: an Internet survey. Therapeutic Advances in Psychopharmacology. 2022;12. doi:10.1177/20451253221082386. https://journals.sagepub.com/doi/full/10.1177/20451253221082386. — Huff C, Finlayson AJR, Foster DE, Martin PR. Enduring neurological sequelae of benzodiazepine use: an Internet survey. Therapeutic Advances in Psychopharmacology. 2023;13. doi:10.1177/20451253221145561. https://journals.sagepub.com/doi/10.1177/20451253221145561. BIND INFOMORMATION— BIND Definition (The Alliance for Benzodiazepine Best Practices) — https://benzoreform.org/BIND — Basics of BIND (Easing Anxiety) — https://easinganxiety.com/BINDBENZODIAZEPINE RESOURCES— The Alliance for Benzodiazepine Best Practices — https://benzoreform.org — Benzodiazepine Information Coalition (BIC) — https://benzoinfo.com — Easing Anxiety (The Benzo Free Podcast) — https://easinganxiety.com — The Benzodiazepine Action Work Group (BAWG) — https://benzoaction.org— A Peacock Consulting (Angela Peacock) — https://apeacockconsulting.com **************************************************************Produced by Easing Anxiety (The Benzo Free Podcast)https://easinganxiety.com **************************************************************DISCLAIMERAll content provided in this video is for general informational purposes only and should never be considered medical or health advice. The presenters in this roundtable are not engaged in rendering medical, health, psychological, or any other kind of personal or professional services. Health-related information provided is not a substitute for medical advice and should not be used to diagnose or treat health problems or to prescribe any medical devices or other remedies. Never disregard medical advice or delay in seeking it.Please visit Easing Anxiety's website for our complete disclaimer at https://www.easinganxiety.com/disclaimer. PRODUCTION CREDITSEasing Anxiety is produced by…Denim Mountain Presshttps://www.denimmountainpress.com 

Huberman Lab Key Takeaways Check Out the Huberman Lab Podcast Episode Page & Show NotesCurious about Andrew Huberman's recipe for good sleep? Read more hereRead the full notes @ podcastnotes.orgIn this episode, I discuss Methyl​enedioxy​methamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and empathy, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTDS, neuroplasticity, mental health and psychiatry. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman Helix Sleep: https://helixsleep.com/huberman ROKA: https://roka.com/huberman HVMN: https://hvmn.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) MDMA “Ecstasy” (00:04:37) Sponsors: Helix Sleep, ROKA, HVMN (00:08:18) MDMA History & Synthesis; Legality (00:14:45) MDMA, Methamphetamine (Meth), Dopamine & Serotonin (00:23:30) MDMA vs Psychedelics vs Ketamine (00:26:54) MDMA & Serotonin 1B Receptor, Subjective Feelings, Trauma (00:33:36) Sponsor: AG1 (Athletic Greens) (00:34:51) Amygdala & Threat Detection, Pro-Social Behavior, MDMA Dosages (00:45:48) Interoception, MDMA & Post-Traumatic Stress Disorder (PTSD) (00:52:36) Long-Term Effects, Threat Detection & PTSD (00:56:14) MDMA, Social Connection & Empathy; Meth, SSRIs (01:06:10) Sponsor: LMNT (01:07:22) Oxytocin & MDMA (01:16:10) Safety & Neurotoxicity; Recreational Use, Caffeine & Fentanyl (01:26:36) Is MDMA Neurotoxic?; Poly-Pharmacology, Body Temperature (01:37:07) Post-MDMA “Crash”, Prolactin & P‑5‑P (01:43:07) PTSD & Trauma; Talk Therapy, SSRIs (01:54:09) PTSD Treatment: Talk Therapy + MDMA (02:02:46) MDMA & Addiction; Dissociative PTSD & Empathy (02:09:47) Side-Effects?, MDMA Efficacy & Legality (02:15:22) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

In this episode, I discuss Methyl​enedioxy​methamphetamine (MDMA), which is also commonly known as “ecstasy” or “molly,” including how it works in the brain to cause short- and long- term-shifts in emotional processing and its clinical applications for the treatment of post-traumatic stress disorder (PTSD), alcohol and other substance-use addictions. I discuss the neuronal mechanisms for how MDMA elevates mood, empathy, motivation, social engagement, and empathy, and reduces “threat detection” and how these effects can synergistically support talk therapy. I also explain the ongoing debate about the potential neurotoxicity of MDMA, myths about the origins and treatments for post-MDMA “crash,” the evolving legal landscape around MDMA use for clinical purposes, and I caution recreational users about the extremely dangerous additives (e.g., fentanyl) now commonly found in black market MDMA. This should be of interest to those curious about MDMA, neuropharmacology, the origins of emotional processing in the brain, empathy, PTDS, neuroplasticity, mental health and psychiatry. For the full show notes, visit hubermanlab.com. Thank you to our sponsors AG1: https://athleticgreens.com/huberman Helix Sleep: https://helixsleep.com/huberman ROKA: https://roka.com/huberman HVMN: https://hvmn.com/huberman LMNT: https://drinklmnt.com/huberman Momentous: https://livemomentous.com/huberman Timestamps (00:00:00) MDMA “Ecstasy” (00:04:37) Sponsors: Helix Sleep, ROKA, HVMN (00:08:18) MDMA History & Synthesis; Legality (00:14:45) MDMA, Methamphetamine (Meth), Dopamine & Serotonin (00:23:30) MDMA vs Psychedelics vs Ketamine (00:26:54) MDMA & Serotonin 1B Receptor, Subjective Feelings, Trauma (00:33:36) Sponsor: AG1 (Athletic Greens) (00:34:51) Amygdala & Threat Detection, Pro-Social Behavior, MDMA Dosages (00:45:48) Interoception, MDMA & Post-Traumatic Stress Disorder (PTSD) (00:52:36) Long-Term Effects, Threat Detection & PTSD (00:56:14) MDMA, Social Connection & Empathy; Meth, SSRIs (01:06:10) Sponsor: LMNT (01:07:22) Oxytocin & MDMA (01:16:10) Safety & Neurotoxicity; Recreational Use, Caffeine & Fentanyl (01:26:36) Is MDMA Neurotoxic?; Poly-Pharmacology, Body Temperature (01:37:07) Post-MDMA “Crash”, Prolactin & P‑5‑P (01:43:07) PTSD & Trauma; Talk Therapy, SSRIs (01:54:09) PTSD Treatment: Talk Therapy + MDMA (02:02:46) MDMA & Addiction; Dissociative PTSD & Empathy (02:09:47) Side-Effects?, MDMA Efficacy & Legality (02:15:22) Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Social Media, Neural Network Newsletter Title Card Photo Credit: Mike Blabac Disclaimer

In part 2 of a 2-part series, Dr. Claudia Zbrzeski discusses the relevant labs, imaging, and EEG data seen in ICANS, as well as prevention and treatment strategies. 

MedLink Neurology Podcast is delighted to feature selected episodes from BrainWaves, courtesy of James E Siegler MD, its originator and host. BrainWaves is an academic audio podcast whose mission is to educate medical providers through clinical cases and topical reviews in neurology, medicine, and the humanities, and episodes originally aired from 2016 to 2021. Originally released: February 20, 2020 Immune checkpoint inhibitors have revolutionized cancer treatment. Unlike chemotherapy, which essentially includes cellular toxins that can cause widespread and unnecessary tissue damage, checkpoint inhibitors are used to train the body's natural immune system to fight off cancer. And while they are extraordinarily effective options for patients with malignant disease, they are not without risk. Every day, we are learning more and more about the autoimmune side effects of these novel therapies. This week on the BrainWaves Podcast, Dr. Justine Cohen (University of Pennsylvania) shares her experience managing patients with checkpoint inhibitor neurotoxicity. Produced by James E Siegler and Justine Cohen. Music courtesy of Jon Watts, Kai Engel, and Kevin McLeod--as well as a cameo appearance by the Checkpoints. Unless otherwise mentioned in the podcast, no competing financial interests exist in the content of this episode. Sound effects by Mike Koenig and Daniel Simion. BrainWaves' podcasts and online content are intended for medical education only and should not be used for clinical decision-making. Be sure to follow us on Twitter @brainwavesaudio for the latest updates to the podcast. REFERENCES Bhatia S, Tykodi SS, Thompson JA. Treatment of metastatic melanoma: an overview. Oncology (Williston Park) 2009;23(6):488-96. PMID 19544689 Cohen JV, Buchbinder EI. The evolution of adjuvant therapy for melanoma. Curr Oncol Rep 2019;21(12):106. PMID 31768772 Cohen JV, Wang N, Venur VA, et al. Neurologic complications of melanoma. Cancer 2020;126(3):477-86. PMID 31725902 Graus F, Dalmau J. Paraneoplastic neurological syndromes in the era of immune-checkpoint inhibitors. Nat Rev Clin Oncol 2019;16(9):535-48. PMID 30867573 Hottinger AF. Neurologic complications of immune checkpoint inhibitors. Curr Opin Neurol 2016 ;29(6):806-12. PMID 27653290 Wick W, Hertenstein A, Platten M. Neurological sequelae of cancer immunotherapies and targeted therapies. Lancet Oncol 2016;17(12):e529-41. PMID 27924751 Zekeridou A, Lennon VA. Neurologic autoimmunity in the era of checkpoint inhibitor cancer immunotherapy. Mayo Clin Proc 2019;94(9):1865-78. PMID 31358366 Zubiri L, Allen IM, Taylor MS, et al. Immune-related adverse events in the setting of PD-1/L1 inhibitor combination therapy. Oncologist 2020;25(3):e398-404. PMID 32162817  We believe that the principles expressed or implied in the podcast remain valid, but certain details may be superseded by evolving knowledge since the episode's original release date.

In part 1 of a 2-part series, Dr. Andy (Ho Wing) Chan discusses the clinical recognition and diagnosis of Immune Effector Cell-Associated Neurotoxicity Syndrome (ICANS).  

Dr. Rachna Malani discusses the potential neurotoxicity associated with CAR-T therapy.    

Dr. Derek Stitt talks with Dr. Rachna Malani, about the potential neurotoxicity associated with CAR-T therapy.

Other than infection, what do you think about as other causes of fever? How can you distinguish sepsis from drug fever from antibiotics? What medications are most likely to cause neurotoxicity? What are some risk factors? How do you think about goals of care with patients? Show notes & Transcript:  https://bit.ly/3Rs57I9Sponsor: Visit www.medmastery.com/coreim for 15% off on all subscriptionsDiscount code: "coreim" Time stamps02:50 Deep Dive #113:12 Deep Dive #226:39 Deep Dive RecapTags: IM Core, CoreIM, antibiotics, CMO, DNR/DNI, sepsis, reflection, grey matters