Podcast appearances and mentions of carol watson

Hello and welcome back to another episode of B Bin Horror! On this week's episode we talk about the 1982 Horror/Slasher, Friday the 13th Part III. Friday the 13th Part III was directed by Steve Miner and written by Martin Kitrosser and Carol Watson. The film stars Dana Kimmell, Paul Kratka and Richard Brooker. On this week's episode the guys talk about the film and what the original script looked like, Dylan's theory on the characters not wiping, the importance of the mask and they also talk about the pregnant girl drinking and smoking. If you like what you hear please follow us on Instagram and Facebook @bbinhorror. You can also send us emails at bbinhorror@gmail.com and please don't forget to subscribe to B Bin Horror on whatever podcast platform you listen on! *B Bin Horror theme music - "Uprising" by Karl Casey @ White Bat Audio*

"The vascular surgeons had felt like, 'The patients are going to you before they come to us and ... why don't we just take you on?' And there was sort of an interest in trying to get me to join up with them, but I told them 'I'm not trained ..." So if I had wanted, I could have ended up in the department of surgery as a nonsurgeon surgeon."—Arthur Waltman, MD, FSIRIn this episode, part of the ongoing celebration of the Society of Interventional Radiology (SIR) 50th anniversary, host Warren Krackov, MD, FSIR, speaks with one of his early mentors, interventional radiology pioneer Arthur Waltman, MD, FSIR, and his wife Carol Watson about the very days of interventional radiology at Mass General, his work with Stanley Baum, MD, FSIR, and others, how the specialty and SIR have grown over the decades, and more. Related resources:SIR 50th Anniversary homepageContact us with your ideas and questions, or read more about about interventional radiology in IR Quarterly magazine or SIR's Patient Center.(c) Society of Interventional Radiology.Support the show

After being killed in Friday the 13th Part III 3D (1982), Jason Voorhees spontaneously revives, escapes from the hospital and returns to Crystal Lake to slaughter more fun-lovin' teens.  Directed by Joseph Zito. Screenplay by Barney Cohen from a story by Bruce Hidemi Sakow. Based on characters by Victor Miller, Ron Kurz, Martin Kitrosser and Carol Watson. Starring Erich Anderson, Judie Aronson, Peter Barton, Kimberly Beck, Corey Feldman, Crispin Glover and Ted White. FOLLOW US ON LETTERBOXD - Zach1983 & MattCrosby Thank you so much for listening! E-mail address: greatestpod@gmail.com Please follow the show on Twitter: @GreatestPod Subscribe on Apple Podcasts / Podbean This week's recommendations: Crystal Lake Memories (Streaming Rental) Midsommar (Showtime)

We've also been asked to host the talks for the Cavan Christian Women's Conference talks from 2022, the speaker was Dr Carol Watson. The first one was recorded live but unfortunately the fire alarm went off and so the second one wasn't recorded live but Carol kindly recorded it afterwards.

Meet Carol Watson, RN, ND, and Health & Body Confidence Coach. Dr. Carol empowers women who are "done with diets" and are ready to let go of the struggle, shame, and guilt that consumes them while shedding some unwanted pounds. Her clients learn to love themselves into a body they can be proud of, regardless of the number on the scale! Listen as Dr. Carol shares the wisdom she gained on her journey to becoming a successful coach, mentor, and entrepreneur. Connect with Dr. Carol: Website - www.TCDrCarol.com/cleanlivingcoach Instagram - https://www.instagram.com/drcarolwatson/ Facebook - https://www.facebook.com/drcarolwatson Linkedin - https://www.linkedin.com/in/drcarolwatson/ Connect with Honor: Email - honoritcoaching@gmail.com Website - www.honoritcoaching.com Facebook - https://www.facebook.com/honor.j.garrett/ Instagram: - https://www.instagram.com/honorgarrett/ Linkedin - https://www.linkedin.com/in/honor-garrett-a3a54561/ Clubhouse - www.clubhouse.com/honorit YouTube - https://www.youtube.com/channel/UC4sPSXbvm74NC7Qf2OyDtSw/videos

NOTE: THIS IS A MATURE PODCAST FOR ADULTS. ADULT LANGUAGE IS USED AND ADULT THEMES ARE DISCUSSED. Two longtime friends spoil, review, and provide their opinions on "Friday the 13th Part 3" directed by Steven Miner, and written by Martin Kitrosser and Carol Watson, while touching on topics such as the kills within the movie, best movie/tv franchises, and 3D.

The vast majority of teachers experience their preparation programs at a tradition university under the guidance of a dedicated group of Faculty. Dr. Carol Watson is one of the Faculty members at Kutztown University. Dr. Watson talks with us about her approach to preparation programming, some of the experiences she shares with her students, and the research that underpins this approach. Plugs include Deliberate Optimism by Debbie Silver, Words Their Way, White Fragility by  Robin DiAngelo, Help Us Begin by Jen Cort, and FieldTrip.com. Music by Ketsa.

HYBRID WORK MODEL  The debate of returning to on-site work locations vs. continuing to work from home looms. As employees were so abruptly thrust into the remote work experience in March 2020, working from home is no longer the major inconvenience that it used to be. Join this discussion with guest expert, Carol Watson, Chief Inclusive Officer at Burson, Cohn & Wolfe, as the country reopens with employees & employers creating a new normal concerning the look, location and logistics of the workplace. Learn more about your ad choices. Visit megaphone.fm/adchoices

Ket tells Kim about the 4th installment of their Friday the 13th series with The Final Chapter written by… everyone. All the writers. We learn that Tommy is the founder of Spirit Halloween's mask collection. We are revisited by the magical towel from all the way back in episode two! All the while, we discover that Jason can fly. Most importantly, we'll learn if Kim will live or die in Friday the 13th: The Final Chapter. Dir. Joseph Zito Writers Victor Miller, Ron Kurz, Martin Kitrosser, Carol Watson, Barney Cohen, Bruce Hidemi Sakow, Sean S. Cunningham Check out Black Women Are Scary Podcast! Follow @blackwomenarescary Donate to their next season! Listen to season 1 of our new horror trivia pod! KIM AND KET'S SURVIVE THE CELLAR link.chtbl.com/kkstc New episodes every other Monday     KKSAM Facebook Discussion Group!! "Sammies Stay Alive... Maybe" www.facebook.com/groups/kksampodcast   Get acquainted with all things KIM & KET at www.kimandketstayalive.com  Chat with the girls at kksampodcast@gmail.com Peep the girls on Instagram:  @kksampodcast Twit the girls on Twitter:  @kksampodcast Book the face of the girls on Facebook:  @kksampodcast Wear the shirts of the girls from the MERCH Store:  kimandketstayalivemaybe.threadless.com Support the girls on PATREON at:  www.patreon.com/kimandketstayalivemaybe Ok we'll see ourselves out. Thanks for listening! xo and #StayAlive, K&K       Proud members of the Dread Podcast Network

We continue our Around the World in 20 Years journey with Carol Watson, the Chief Inclusion Officer at global communications agency BCW. Previously, worked at Carol Diversity Best Practices and Working Mother Media, where she was at the time a Senior Director of Global Advisory and Consulting. There she was responsible for advising and consulting 200+ mid- to large-sized organizational leaders at all levels on how to best leverage proven and innovative diversity initiatives and sustainable culture change strategies. Carol also co-founded the marketing and media industry initiative Inclusive100 with She Runs It, which brings together the advertising, media and marketing ecosystem to benchmark workforce, workplace and inclusive culture progress and share best practices with 30+ marketing organizations participating quarterly. Carol Watson has a deep understanding of the business approach to embedding inclusion and the metrics-driven practices of building and nurturing a truly inclusive organization. We talk quite a bit about this in our conversation, how DEI is both an art and science and how in this innovative DEI landscape, having a baseline understanding of the art and science is still critical. FULL SHOW NOTES & TRANSCRIPT: https://languageandculture.com/around-the-world-in-the-world-in-20-years-with-carol-watson-bcw/ GUEST INFO: Put LinkedIn here, or company website. RESOURCES: https://www.linkedin.com/in/carolawatson/ LCW LINKEDIN: https://www.linkedin.com/company/language-&-culture-worldwide/ LCW FACEBOOK: https://www.facebook.com/LanguageAndCultureWorldwide

Join us for our review of the 1982 Slasher Film, Friday the 13th Part III. Directed by Steve Miner and written by Martin Kitrosser and Carol Watson.

Dr. Carol Watson on Loving Yourself   In this episode, Dr. Carol shares her transformation journey. When Dr. Carol achieved National Marketing Director in 2004, she was “well over 300 pounds” and she not only struggled with a food addiction but also with shame. Dr. Carol shares her story of losing more than 130 pounds since 2014 and learning that loving herself is the key to loving others. This isn’t just a story of body change; this is a story of mindset and heart change. No matter who you are and no matter your struggle, you will be encouraged by Dr. Carol. She is a force; her invitation to all of us is to see ourselves as God sees us. When we do, not only will our life change but God will be able to work through us to impact many lives.  Disclaimer: Juice Plus+ does not claim to cure or treat any specific disease or symptoms and makes no income promises regarding the business.

Kim tells Ket about the third installment of their journey through Friday the 13th with part III in 3D starring  Dana Kimmell (https://www.imdb.com/name/nm0454011/?ref_=tt_ov_st_sm) , Tracie Savage (https://www.imdb.com/name/nm0767394/?ref_=tt_ov_st_sm) , and Richard Brooker (https://www.imdb.com/name/nm0111777/?ref_=tt_ov_st_sm) . And we finally get some hockey mask up in this piece! Ket learns that being the daughter of a horse girl is really gonna come in handy when barn science is needed. The girls also really hope there is a chiropractor at Crystal Lake. So let’s stroke the fire, #sammies! Most importantly, we’ll learn if Ket will live or die in Friday the 13th Part III 3D. Dir. Steve Miner Writers Martin Kitrosser, Carol Watson           KKSAM Facebook Discussion Group!! "Sammies Stay Alive... Maybe" https://www.facebook.com/groups/kksampodcast     Get acquainted with all things KIM & KET at www.kimandketstayalive.com (http://www.kimandketstayalive.com/)   Chat with the girls at kksampodcast@gmail.com Peep the girls on Instagram:  @kksampodcast (http://www.instagram.com/kksampodcast/) Twit the girls on Twitter:  @kksampodcast (https://twitter.com/kksampodcast) Book the face of the girls on Facebook:  @kksampodcast (https://www.facebook.com/kksampodcast) Wear the shirts of the girls from the MERCH Store:  https://kimandketstayalivemaybe.threadless.com Support the girls on PATREON at:  http://www.patreon.com/kimandketstayalivemaybe Ok we'll stop now. Thanks for listening! xo and #StayAlive, K&K       Proud members of the Dread Central Podcast Network

Kim tells Ket about the third installment of their journey through Friday the 13th with part III in 3D starring  Dana Kimmell, Tracie Savage, and Richard Brooker. And we finally get some hockey mask up in this piece! Ket learns that being the daughter of a horse girl is really gonna come in handy when barn science is needed. The girls also really hope there is a chiropractor at Crystal Lake. So let's stroke the fire, #sammies! Most importantly, we'll learn if Ket will live or die in Friday the 13th Part III 3D. Dir. Steve Miner Writers Martin Kitrosser, Carol Watson           KKSAM Facebook Discussion Group!! "Sammies Stay Alive... Maybe" www.facebook.com/groups/kksampodcast     Get acquainted with all things KIM & KET at www.kimandketstayalive.com  Chat with the girls at kksampodcast@gmail.com Peep the girls on Instagram:  @kksampodcast Twit the girls on Twitter:  @kksampodcast Book the face of the girls on Facebook:  @kksampodcast Wear the shirts of the girls from the MERCH Store:  kimandketstayalivemaybe.threadless.com Support the girls on PATREON at:  www.patreon.com/kimandketstayalivemaybe Ok we'll stop now. Thanks for listening! xo and #StayAlive, K&K       Proud members of the Dread Central Podcast Network See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

In our second episode, we feature PHL Diversity Brain Box and Lead Generation Committee members Tami Sortman, Vice President of the Philadelphia Gay Tourism Caucus, Janice Sykes-Ross, Director of The Belmont Mansion and Carol Watson, General Manager Kimpton Hotel Palomar Philadelphia. The Brain Box Committee guides PHL Diversity’s journey of innovation by creating new ideas, concepts, and practices. The Lead Generation Committee cultivates and filter leads to increase Philadelphia's share of the diverse/multicultural meetings and conventions. Together, they are producing our upcoming webinar “Welcoming Multicultural Meetings and Conventions Back: How Philadelphia’s Transportation Hubs are Preparing for Visitors” scheduled for Wednesday, October 14th.

Episode Notes Welcome to the Cower Hour, where every two weeks Briar and Nora take you on a journey into horror! This episode, we dip back into the Jason well with 1982's Friday the 13th Part III (in 3D)!! Written by Martin Kitrosser, Carol Watson, Petru Popescu (uncredited), and directed by Steve Miner! Next Episode: Van Helsing (2004)!! Follow Briar on Twitter at twitter.com/weregazelle! Follow Nora on Twitter at twitter.com/NeitherNora or twitter.com/xoetics!

Some sobering statistics emerged from the recent #Inclusive100 survey of the media/marketing industry: Women and people of color are actually declining in the executive ranks. In this conversation with survey creators, Lynn Branigan, president and CEO of She Runs It, and Carol Watson, senior director at Diversity Best Practices, tell MediaVillage how we can do better and get it right - starting with the need to benchmark where we're at now.  Learn about the three goals of "100" that inspired their #Inclusive100 survey. “Companies really want to know how to  move forward. ... You can't just say you've been doing a lot, you have to measure, and understand what's happening with LGBTQ shifts, disability, veterans...all of those things. It's a very holistic, data-based approach which has been really missing in the marketplace. ...It’s like going to the doctor for your annual checkup. It's not a five-minute visit, it’s a great diagnostic scan and we all have to take our medicine,” Watson says. Learn why marketing + measurement are the biggest drivers of success through this podcast, and through MediaVillage’s Advancing Diversity initiative. In fact listen to the previous interviews with all of this year’s inductees to the Advancing Diversity Hall of Honors. There will be more coverage on MediaVillage of the forthcoming Honors, Council meeting, the Diversity Job Meet-Up and the Creative Tensions® experience all taking place during CES on January 8th in Las Vegas.

The first ten installments of the classic horror franchise are served up in one fun and continuous tale. When you think of epic sagas of the human spiritrich treasure troves of narrative excellence,and pure storytelling dynamite you naturally think of Friday the 13thNormally I write my own stories, but this time I had a little help from the writers and directors of the friday the 13 films, Sean Cunningham, Victor Miller, Steve Miner, Ron Kurz, Martin Kitrosser, Carol Watson, Joseph Zito, Barney Cohen, Danny Steinmann, David Cohen, Tom Mcloughlin, John Carl Buechler, Manuel Fidello, Daryl Haney, Rob Hedden, Adam Marcus, Jay Huguely, Dean Lorey, James Isaac, and Todd Farmer. produced and edited by J—j-j-jeff D-d-d-davidsonmusic by:A2-Tactile by Rien Virgule Bio-Unit - ApexSilicone Transmitter - FurnaceArbus- I was a Cyborg from Outer SpaceTheme music by Chelsea OxendinePlease subscribe through Buzzsprout, Stitcher, Spotify, or iTunesFind me on social media on Instagram Facebook and Twitter, or email me direct at AScaryHomeCompanion@gmail.comSupport the show (https://www.patreon.com/ascaryhomecompanion)

There's just not enough female voices. When it comes to business, and property in particular, the quota is not high enough. On today's show, we've got two powerful female voices that are able to help in that area. Carol Watson and Lisa Smith, are not only inspirational business women, but are causing waves of success in different parts of the property world, and they've now launched their very own podcast too! The Life Balance Podcast. Carol and Lisa chat about their lives, their businesses, their strategies, their experiences, and their desire to have more female voices speak up, and their mission and legacy for using property and business to leave a positive mark on the world and help many people benefit from that success. FOR FULL EPISODE AND RESOURCES VISIT OUR WEBSITE Don't ask why. Ask, why not... Women in business, women in property, glass ceilings, the maternal piece, and wanting it all... From the odd one out at a networking event, to speaking at the front of the room... Sourcing, refurbs, investors, and land developments... Working with someone with the same values and principles...

In this episode we discuss the 1982 classic, Friday the 13th Part 3. Directed by Steve Minor, written by Martin Kitrosser and Carol Watson, and starring Dana Kimmell, Tracie Savage and Richard Brooker.

Who can really get involved in property, business and investing? That's a theme that's come from many listeners' questions in recent weeks. Can I do it? Can anyone do it? Is property investing not some old, dull world dominated by old white men at the end of their corporate lives with tons of pension cash to buy discounted properties? What about me; have asked our female listeners. Will having these young kids stop me from having my own business; have asked our newbie parent listeners. Do I need to wait; have asked our young listeners. The short answer is no... In today's show, Richard sits down with inspirational Carol Watson, and they cover the trail she's blazing in the world of property. Her childhood, her background, and the experiences that formed her mindset and approach to life. They cover the juggling act of being focused and determined with clearly defined goals, but yet also being open and relaxed about change, and twists in the road. From the sourcing of individual deals for investor clients, to being a shareholder in a major land and new build development project, Carol tells her story and shows how you the listener can jump into the exciting, different, and rewarding world of property... FOR FULL EPISODE AND RESOURCES VISIT OUR WEBSITE The childhood experiences that helped Carol form her skills and strategies that help her succeed in business... Balancing the focused determination to chase a goal, with a laid-back response to change... The world of property investing is not the domain of fusty old white men with lots of money... Mindset, curiosity, and hunger: the fuel behind success... Networking and connecting: how to grow beyond the circle you're in... From sourcing individual deals for clients, to being part of large scale land and new build developments...

Carol Watson’s Greenhouse and Landscaping is a jewel in Lafayette, NY, a farming community not far from Syracuse. The Greenhouse is home to exotic plants, waterfalls, garden art, and unique pots. It’s a magical oasis, and Carol hosts several events here, including Celebration of the Senses, which showcases local musicians, artists and chefs. She donates the proceeds to local charities, such as the Rescue Mission and Symphoria. She also hosts a popular Greenhouse Yoga class. You can find out more about this beautiful sanctuary at: CarolWatsonGreenhouse.com. Find out more about the Zestful Aging Podcast at NicoleChristina.com. You can become a patron of the Show at Patreon.com.

Carol Watson, General Manager at the Kimpton Hotel Palomar, joins the PHL Diversity podcast to discuss her unconventional path to the top and highlight the importance of diversity within positions of influence, providing advice to young professionals on how to accomplish their goals and achieve success.

This episode unpacks some of the many challenges associated with changing gender norms. Part 1: The paradoxical nature of change creates challenges Part 2: What are the wider conditions needed to facilitate change? Part 3: Even if change is happening, there are powerful forces pushing back Interviewees (May also appear in the previous and following episode) Carol Watson, independent researcher Dr Florence Kyoheirwe Muhanguzi, Senior Researcher, Makerere University, Uganda Paola Pereznieto, Research Associate, ODI Dr Fiona Samuels, Senior Research Fellow, ODI

Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr. Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. Today we will be discussing the pooled analysis results of the 10 ODYSSEY Trials with important implications for the reduction of lipids in major cardiovascular events. But first, here's your summary of this week's journal. The first paper provides experimental data on vascular disease that brings into focus the critical roles of transcription factors such as GATA2 in the maintenance of endothelial cell function, as well as the role of selected microRNAs as a novel player of vascular regulation. In this study by first author Dr. Hartman, corresponding author Dr. Thum from Hanover Medical School, and colleagues, authors used GATA2 gain and loss of function experiments in human umbilical vein endothelial cells to identify a key role of GATA2 as a master regulator of multiple endothelial functions, and this via microRNA-dependent mechanisms. Global microRNA screening identified several GATA2-regulated microRNAs, including miR-126 and miR-221. GATA2 deficiency led to vascular abnormalities, whereas supplementation with miR-126 normalized vascular function. In a mouse model of carotid injury, GATA2 was reduced and systemic supplementation of miR-126-coupled nanoparticles enhanced miR-126 availability in the carotid artery and improved reendothelialization of injured carotid arteries in vivo. In summary, GATA2-mediated regulation of miR-126 and miR-221 has an important impact on endothelial biology. Thus, modulation of GATA2 and its targets miR-126 and miR-221 represents a promising therapeutic strategy for the treatment of vascular diseases. The next study is the first to show that current smokers from the general population have lower levels of circulating cardiac troponin I, a seemingly paradoxical observation given the known detrimental cardiovascular impact of cigarette smoking. First author Dr. Lyngbakken, corresponding author Dr. Omland, and colleagues from the University of Oslo used data from the large population-based HUNT study, in which cardiac troponin I was measured in 3,824 never smokers, 2,341 former smokers, and 2,550 current smokers. Current smokers had significantly lower levels of cardiac troponin I than never smokers and former smokers, an association that remains significant even after adjustment for potential confounders. The authors also found an association between increasing concentrations of troponin I and clinical endpoints, namely acute myocardial infarction, heart failure, and cardiovascular death in the total cohort. However, this association was attenuated in current smokers and was significantly weaker than in never or former smokers with a p for interaction of 0.003. The prognostic accuracy of troponin I as assessed by C-statistics was lower in current smokers than in never smokers. Troponin I provided no incremental prognostic information to the Framingham Cardiovascular Disease risk score in the current smokers. Together, these results suggest that mechanistic pathways other than those involving subclinical myocardial injury may be responsible for the cardiovascular risk associated with current smoking. Future studies are needed to determine whether a lower cardiac troponin I threshold should be considered for exclusion of myocardial infarction in smokers or whether prognostic tools other than measurement of cardiac troponins should be utilized when evaluating risk of future events in current smokers. The next study contributes to our understanding of cardiomyocyte signaling in response to ischemic injury. In the study by first author Dr. [Wool 00:05:04], corresponding author Dr. [Ju 00:05:04] from Tongji University School of Medicine in Shanghai, and colleagues, authors sought to understand the role of low-density lipoprotein receptor-related proteins 5 and 6 as well as beta-catenin signaling in the heart. They did this using conditional cardiomyocyte-specific knockout mice who had surgically induced myocardial infarction. They found that deletion of lipoprotein receptor-related proteins 5 and 6 promoted cardiac ischemic insults. Conversely, deficiency of beta-catenin, a downstream target, was beneficial in ischemic injury. Interestingly, although both insulin-like growth factor-binding protein 4 and Dickkopf-related protein 1 are secreted beta-catenin pathway inhibitors, the former protected the ischemic heart by inhibiting beta-catenin, whereas the latter enhanced the injury response mainly through inducing lipoprotein-related protein 5 and 6 endocytosis and degradation. These findings really add to our understanding of the beta-catenin signaling pathway in ischemic injury and suggests that new therapeutic strategies in ischemic heart disease may involve fine-tuning these signaling pathways. The next paper from the International Consortium of Vascular Registries is the first study allowing an assessment of variations in repair of abdominal aortic aneurysms in 11 countries over 3 continents represented by the Society of Vascular Surgery and European Society for Vascular Surgery. Dr. Beck from University of Alabama-Birmingham School of Medicine, and colleagues, looked at registry data for open and endovascular abdominal aortic aneurysm repair during 2010 to 2013, collected from 11 countries. These were Australia, Denmark, Hungary, Iceland, New Zealand, Norway, Sweden, Finland, Switzerland, Germany, and the United States. Among more than 51,000 patients, utilization of endovascular aortic repair for intact aneurysms varied from 28% in Hungary to 79% in the United States, and for ruptured aneurysms from 5% in Denmark to 52% in the United States. In addition to the between-country variations, significant variations were present between centers within each country in terms of endovascular aortic repair use and rate of small aneurysm repair. Countries that more frequently treated small aneurysms tended to use the endovascular approach more frequently. Octogenarians made up 23% of all patients, with a range of 12% in Hungary to 29% in Australia. In countries with a fee for service reimbursement systems, such as Australia, Germany, Switzerland, and the United States, the proportion of small aneurysms and octogenarians undergoing intact aneurysm repair was higher compared to countries with a population-based reimbursement model. In general, center-level variation within countries in the management of aneurysms was as important as variation between counties. Hence, this study shows that despite homogeneous guidelines from professional societies, there is significant variation in the management of abdominal aortic aneurysms, most notably for intact aneurysm diameter at repair, utilization of endovascular approaches, and the treatment of elderly patients. These findings suggest that there is an opportunity for further international harmonization of treatment algorithms for abdominal aortic aneurysms. This is discussed in an accompanying editorial entitled, Vascular Surgeons Leading the Way in Global Quality Improvement, by Dr. Fairman. The final paper from Dr. Gibson at Beth Israel Deaconess Medical Center and Harvard Medical School and colleagues, presents the results of the apoAI event reducing in ischemic syndromes I, or AEGIS-I, trial, which was a multicenter, randomized, doubleblind, placebo-controlled dose-ranging phase 2b trial of CSL112, which is an infusible, plasma-derived apoAI that has been studied in normal subjects and those with stable coronary artery disease, but now studied in the current study in patients with acute myocardial infarction. The trial showed that among patients with acute myocardial infarction, four weekly infusions of a reconstituted, infusible, human apoAI, CSL112, was associated with a dose-dependent elevation of circulating apoAI and cholesterol efflux capacity without adverse hepatic or renal outcomes. The potential benefit of CSL112 to reduce major adverse cardiovascular events will need to be assessed in an adequately powered phase 3 trial. Now for our future discussion. Today I am delighted to have with us Dr. Kausik Ray from Imperial College London, who's the first and corresponding author of a new paper regarding the pooled analysis of the 10 ODYSSEY Trials. To discuss it with us is Dr. Carol Watson, associate editor from UCLA. Kausik, just let me start by congratulating you on this paper. I believe this is the first data that allows us to look under the 50 mg/dL mark of LDL and really ask if the LDL MACE relationship extends below this level. Dr. Kausik Ray: Yes, the reason for looking at this is that the IMPROVE-IT trial really looked at people down to an average LDL cholesterol of about 54, and with the new PCSK9 inhibitors, which instead of giving you a 20% further reduction LDL, they give you the opportunity for a further 50 to 60% reduction. We actually get the chance to get people down to levels like 25 mg/dL, and the question is, does the benefit continue at that level? We did a pooled analysis of 10 of the ODYSSEY Trials, really in some ways to try and help predict what you might see in ODYSSEY outcomes, what you might see in the [Fuliay 00:12:00] trial, and to also manage expectations as well, because there's probably been a lot of hype around the two New England Journal papers about 50, 60% reductions of all potential reductions based on small numbers of events. So the question is, if you reduce LDL by 39 mg/dL, how might that reduce your risk, and is the relationship continuous? So those were the aims. Dr. Carolyn Lam: That's great, and maybe could you give us an idea of the number of patients you are looking at and the number of events? Dr. Kausik Ray: Yeah. In the 10 pool studies, we had just under 5,000 individuals, and we had just about 6,700 person years' worth of followup. In total, we had 104 first MACE events. To put this into context, it's about one third of the number of events that the first [framing 00:12:53] of analysis had. It's an observation analysis rather than randomized trial data, so you got to bear that in mind with the usual caveats that go with observational data. But the same endpoints that were adjudicated, this is [inaudible 00:13:10] heart disease death, non-fatal MI, ischemic stroke, and unstable angina requiring hospitalization. This is the same endpoint that is in the ODYSSEY Outcomes Trial, so it's interesting in that regard. Dr. Carolyn Lam: Yeah, it sure is. So what's the bottom line? What did you find? Dr. Kausik Ray: What we found was that there was a continuous relationship all the way down to LDL cholesterol levels of about 25 mg/dL, that every 39 mg/dL lower on treatment LDL, your risk went down by about 24%. If you looked at [apo-like 00:13:48] approaching be on non-HDL cholesterol, again, you found the same continuous relationship with a similar point estimate for a similar standardized difference in LDL cholesterol. We also looked at many of the guidelines, talk about percentage reduction. We actually looked at percentage reductions. If you start with a baseline LDL of X and you achieve a 50% further reduction in LDL, how much further benefit does that give you? A 50% further reduction gave you a 29% further lower risk of MACE. So we didn't find any threshold or limit all the way down to LDLs of about 25. Dr. Carolyn Lam: That's really a key, novel finding that you contributed, so congratulations once again. I suppose the question will always be, you're talking about relative risk reductions here. At such low levels, can you give us an idea of the absolute risk reductions? Dr. Kausik Ray: Yes. You've got to remember that the relative risk reductions are what you can apply to population differences. If you pick a high-risk patient population, you would expect to see a much bigger absolute risk reduction than maybe this study or another study. Similarly, if you pick a low-risk group, you are going to see a much smaller absolute benefit. I always try to advise a little bit of caution that if you basically look at the range ... If you start with let's say an LDL of 150 and you go down to let's say an LDL of 25, you are talking about a 1.25% absolute risk reduction. Remember, these patients are possibly going to be a slightly lower risk than the ones that are recruited into the ODYSSEY Outcomes and into the [Fuliay 00:15:46] trial, for example. Dr. Carolyn Lam: I think you mentioned what I was going to just ask you about. This is observational. You had 104 events, and I suppose another limitation might be that your followup was two years at max, if I'm not wrong? What do you say about that, and are there plans for future analyses? Dr. Kausik Ray: Within the context of these studies, I think that the whole of this data will eventually become dwarfed by what we see with the big CDOTs, because you've got 18, 27,000 people, 3 years' worth of exposure and followups, so you are going to have many, many more events. That is a limitation, but I think what is interesting is that we know that the baseline LDL cholesterol level is around about 90 mg/dL. We don't actually know what the actual baseline ... because the baseline [characters 00:16:43] haven't been published for ODYSSEY Outcomes, but the [Fuliays 00:16:46] around about 89. What it tells you is what the point estimate is likely to be. It's likely to be in the 24 to 32% ballpark because that's what your baseline LDL is and that's what we'd predict in the regression lines that we observed here. I think that we're not going to get many more events in these studies because largely the randomized period of followup is now over. Many of these people are now into open labels, extensions for safety, so we won't get many more events from this. In terms of, I think, the way people should maybe look at this is possibly as a taster for what's to come in the next 18 months or so. I think for the time being it answers two questions. Is lower likely to be better? And it is. I think the other question it tells is how might you get people down to LDLs below 50? One of the important things was that if you were just on statins, in this population, if you were recruited on the basis of a high baseline LDL, you got no additional people down to LDLs below 50. You got under 10% with add-on [inaudible 00:18:05], but you got around about 50% when you used the PCSK9 inhibitor as an add-on to existing therapy. It tells you about how to get to such low levels as well. I think that's the other key thing that it actually gives you. We did an analysis of safety [inaudible 00:18:23], and I think that's really important. Once you see the efficacy, or if you see the MACE events continue to go down ... If you looked at treatment-emergent adverse events ... and I completely take the fact that it's every side effect reported altogether, which may or may not be linked to LDL levels specifically, but when we did that, the relationship actually was just a horizontal line, so there was no relationship with percentage reduction or on treatment LDL, so it gave us a nice idea of both safety and efficacy that we might experience in the big outcome studies. Dr. Carolyn Lam: All right. Obviously the big outcome studies are going to be game changers, and I'd really love to invite [Carol Scotts 00:19:09] here, because there's a whole lot of other things that need to be considered if this becomes the case, isn't it? Carol, I really appreciated that you invited an editorial, and the editorial is by Neil Stone who entitles it, Looking Beyond Statins: Will the Dollars Make Cents? Please tell us about the discussions about this paper that occurred. Dr. Carol Lam: I would again like to congratulate Dr. Ray on a fantastic paper, and I would like to reiterate exactly what he said. I think it really does give us some comfort about this class of medication and its relative safety. I think that's very important, because I can't tell you how many patients I get and how many referring physicians I get who worry when their patients come back with LDLs of 20 or below. I think that gave us some comfort, and I do also think it was very important to show that this would fall along the same regression line that statins perhaps would fall. As with all the caveats that Dr. Ray said, I agree with all of them, but I do say this is a tasty little taster, and I appreciate and congratulate you for publishing this. The editorial by Dr. Neil Stone was quite interesting. As you said, he subtitled it, Will the Dollars Make Cents? C E N T S or S E N S E, sort of a play on words there. Will the relative benefits that we can achieve with this class of medications make sense for the cost of these drugs? That's obviously a very separate issue from what was discussed in the manuscript, but it's something to think about. We understand that there are additional patients that will be helped if they can get their LDL down, and we hope that that will translate into the outcomes. Again, just as Dr. Ray mentioned, we will have to wait for the cardiovascular outcomes trials to be completed. When they are, if they do show the benefits that we hope, will their price point make them accessible to enough patients for this to be a widely applied, utilized therapy? Or will they not? That's part of what was discussed in Dr. Stone's editorial. Dr. Kausik Ray: When we were writing the manuscript and stuff like that, and we were doing this and everybody's like, "Oh, wow, look at the graphs." I said, "Look, we need to balance all of these bits and reassure ... We've got an opportunity." So I suggested them giving those additional analyses, and you saw how big the online supplement was. There was a ton of work that we put into this, and to format it into a concise ... I really want to just thank the editorial board for giving us the chance and actually being able to help us and work with us on this, because it's really important. I hope people look at all of those things because it will help people also that question the LDL. They all talk about the hypothesis and the safety of really low LDLs, and people come off statins as a result. I think this will help. Dr. Carolyn Lam: You're listening to Circulation on the Run. Thank you so much for being with us, and don't forget to tune in next week.

Welcome to The BrandLab's "Three Fearless Questions" created and produced by students of The BrandLab. In this episode of "3 Fearless Questions," Ellen Walthour talks with Carol Watson. Carol serves on the Board of Directors of Advertising Women of New York and the Mosaic Committee for the American Advertising Federation. She is a tireless advocate for diversity in the ad business and recently launched the cross-cultural career hub www.thrivev.com. Continue the conversation online with the hashtag #3FQ or go to www.thebrandlab.org/fearless to learn more. Have an idea for a 3FQ podcast guest? Email The BrandLab's Development Director, Brian Gioielli at bgioielli@thebrandlab.org.

Unleash Your Magnificence! Who is Driving Your Life? Is your life being driven by the Fear of Success? Are you being driven by the Fear of Failure? Can you answer these questions? It is time to make a commitment to yourself. THE JOURNEY STARTS NOW! What do you want to walk away with, from this journey?Your Host is Goddess Arianmor an Intuitive Life Coach, Healer, Teacher & channel of love, support & encouragement. Together we will explore the possibilities. For a consultation arianmor@gmail.com or Skype - Goddess.Arianmor You can now download my podcasts at iTunes. About Carol Watson: After experiencing the devastation of job burnout, Carol turned the lowest point of her life into a time of Self exploration and healing. Delving into the Goddess Archetypes and embracing her own divine feminine role Changed Carol’s life forever. By learning to re-connect with her own divine power and potential, she found the divine power for the potential for greatness that exists in each of us. By developing her own intuitive healing abilities, she blends her practical knowledge and skills with her deep celtic roots to assist individuals in their own healing ability. She offers workshops, meditations, webinars, radio shows, group coaching & intuitive counseling along with private consultations to assist individuals to unravel their own divine goddess gifts within. Today we will be taking our first steps together to manifest our greatest potential and joy with Carol being our guide in re-claiming our magnificence from within.

Unleash Your Magnificence! Who is Driving Your Life? Is your life being driven by the Fear of Success? Are you being driven by the Fear of Failure? Can you answer these questions? It is time to make a commitment to yourself. THE JOURNEY STARTS NOW! What do you want to walk away with, from this journey?Your Host is Goddess Arianmor an Intuitive Life Coach, Healer, Teacher & channel of love, support & encouragement. Together we will explore the possibilities. For a consultation arianmor@gmail.com or Skype - Goddess.Arianmor You can now download my podcasts at iTunes. About Carol Watson: After experiencing the devastation of job burnout, Carol turned the lowest point of her life into a time of Self exploration and healing. Delving into the Goddess Archetypes and embracing her own divine feminine role Changed Carol’s life forever. By learning to re-connect with her own divine power and potential, she found the divine power for the potential for greatness that exists in each of us. By developing her own intuitive healing abilities, she blends her practical knowledge and skills with her deep celtic roots to assist individuals in their own healing ability. She offers workshops, meditations, webinars, radio shows, group coaching & intuitive counseling along with private consultations to assist individuals to unravel their own divine goddess gifts within. Today we will be taking our first steps together to manifest our greatest potential and joy with Carol being our guide in re-claiming our magnificence from within.

Unleash Your Magnificence! Who is Driving Your Life? Is your life being driven by the Fear of Success? Are you being driven by the Fear of Failure?Can you answer these questions? It is time to make a commitment to yourself.THE JOURNEY STARTS NOW!You are the star of your life and this is the time to live it! Together we will explore the possibilities and create the magnificent life that you are born and destined to live. This is why you are here. What do you want to walk away with, from this journey?Your Host for this call is Goddess Arianmor an Intuitive Life Coach, Healer, Teacher and channel of love, support and encouragement. Together we will explore the possibilities.For a private consultation contact me at arianmor@gmail.com, www.carolwatson.ca or via Skype contact name: Goddess.Arianmor Please rate my podcasts on itunes: http://itunes.apple.com/us/podcast/goddess-arianmor-cosmic-ordering/id391087137  Namaste Goddess Arianmor

Unleash Your Magnificence! Who is Driving Your Life? Is your life being driven by the Fear of Success? Are you being driven by the Fear of Failure?Can you answer these questions? It is time to make a commitment to yourself.THE JOURNEY STARTS NOW!You are the star of your life and this is the time to live it! Together we will explore the possibilities and create the magnificent life that you are born and destined to live. This is why you are here. What do you want to walk away with, from this journey?Your Host for this call is Goddess Arianmor an Intuitive Life Coach, Healer, Teacher and channel of love, support and encouragement. Together we will explore the possibilities.For a private consultation contact me at arianmor@gmail.com, www.carolwatson.ca or via Skype contact name: Goddess.Arianmor Please rate my podcasts on itunes: http://itunes.apple.com/us/podcast/goddess-arianmor-cosmic-ordering/id391087137  Namaste Goddess Arianmor

Unleash Your Magnificence! Who is Driving Your Life? Is your life being driven by the Fear of Success? Are you being driven by the Fear of Failure?Can you answer these questions? It is time to make a commitment to yourself.THE JOURNEY STARTS NOW!You are the star of your life and this is the time to live it! Together we will explore the possibilities and create the magnificent life that you are born and destined to live. This is why you are here. What do you want to walk away with, from this journey?Your Host for this call is Goddess Arianmor an Intuitive Life Coach, Healer, Teacher and channel of love, support and encouragement. Together we will explore the possibilities.For a private consultation contact me at arianmor@gmail.com, www.carolwatson.ca or via Skype contact name: Goddess.Arianmor Please rate my podcasts on itunes: http://itunes.apple.com/us/podcast/goddess-arianmor-cosmic-ordering/id391087137  Namaste Goddess Arianmor

Unleash Your Magnificence! Who is Driving Your Life? Is your life being driven by the Fear of Success? Are you being driven by the Fear of Failure?Can you answer these questions? It is time to make a commitment to yourself.THE JOURNEY STARTS NOW!You are the star of your life and this is the time to live it! Together we will explore the possibilities and create the magnificent life that you are born and destined to live. This is why you are here. What do you want to walk away with, from this journey?Your Host for this call is Goddess Arianmor an Intuitive Life Coach, Healer, Teacher and channel of love, support and encouragement. Together we will explore the possibilities.For a private consultation contact me at arianmor@gmail.com, www.carolwatson.ca or via Skype contact name: Goddess.Arianmor Please rate my podcasts on itunes: http://itunes.apple.com/us/podcast/goddess-arianmor-cosmic-ordering/id391087137  Namaste Goddess Arianmor

Unleash Your Magnificence!Who is Driving Your Life?Is your life being driven by the Fear of Success? Are you being driven by the Fear of Failure?Can you answer these questions? It is time to make a commitment to yourself.THE JOURNEY STARTS NOW!You are the star of your life and this is the time to live it! Together we will explore the possibilities and create the magnificent life that you are born and destined to live. This is why you are here. What do you want to walk away with, from this journey?Your Host for this call is Goddess Arianmor an Intuitive Life Coach, Healer, Teacher and channel of love, support and encouragement. Together we will explore the possibilities.For a private consultation contact me at arianmor@gmail.com, www.carolwatson.ca or via Skype contact name: Goddess.Arianmor Please rate my podcasts on itunes: http://itunes.apple.com/us/podcast/goddess-arianmor-cosmic-ordering/id391087137  Namaste Goddess Arianmor

Unleash Your Magnificence!Who is Driving Your Life?Is your life being driven by the Fear of Success? Are you being driven by the Fear of Failure?Can you answer these questions? It is time to make a commitment to yourself.THE JOURNEY STARTS NOW!You are the star of your life and this is the time to live it! Together we will explore the possibilities and create the magnificent life that you are born and destined to live. This is why you are here. What do you want to walk away with, from this journey?Your Host for this call is Goddess Arianmor an Intuitive Life Coach, Healer, Teacher and channel of love, support and encouragement. Together we will explore the possibilities.For a private consultation contact me at arianmor@gmail.com, www.carolwatson.ca or via Skype contact name: Goddess.Arianmor Please rate my podcasts on itunes: http://itunes.apple.com/us/podcast/goddess-arianmor-cosmic-ordering/id391087137  Namaste Goddess Arianmor

Unleash Your Magnificence!Who is Driving Your Life?Is your life being driven by the Fear of Success? Are you being driven by the Fear of Failure?Can you answer these questions? It is time to make a commitment to yourself.THE JOURNEY STARTS NOW!You are the star of your life and this is the time to live it! Together we will explore the possibilities and create the magnificent life that you are born and destined to live. This is why you are here. What do you want to walk away with, from this journey?Your Host for this call is Goddess Arianmor an Intuitive Life Coach, Healer, Teacher and channel of love, support and encouragement. Together we will explore the possibilities.For a private consultation contact me at arianmor@gmail.com, www.carolwatson.ca or via Skype contact name: Goddess.Arianmor Please rate my podcasts on itunes: http://itunes.apple.com/us/podcast/goddess-arianmor-cosmic-ordering/id391087137  Namaste Goddess Arianmor

Unleash Your Magnificence!Who is Driving Your Life?Is your life being driven by the Fear of Success? Are you being driven by the Fear of Failure?Can you answer these questions? It is time to make a commitment to yourself.THE JOURNEY STARTS NOW!You are the star of your life and this is the time to live it! Together we will explore the possibilities and create the magnificent life that you are born and destined to live. This is why you are here. What do you want to walk away with, from this journey?Your Host for this call is Goddess Arianmor an Intuitive Life Coach, Healer, Teacher and channel of love, support and encouragement. Together we will explore the possibilities.For a private consultation contact me at arianmor@gmail.com, www.carolwatson.ca or via Skype contact name: Goddess.Arianmor Please rate my podcasts on itunes: http://itunes.apple.com/us/podcast/goddess-arianmor-cosmic-ordering/id391087137  Namaste Goddess Arianmor