Podcasts about Thum

In this special episode of The Lawyers Weekly Show, produced in partnership with The College of Law, we reflect on how the new Right to Disconnect laws can and will facilitate mindset and communication shifts in professional services workplaces and why those in law should see these laws as a “moment for potential growth”. Host Jerome Doraisamy speaks with Florence Thum, a lecturer and assistant director in NSW for PLT at The College of Law, about her reflections on the advent and passage of the new Right to Disconnect laws, the need for law firms to realign their priorities, adopting a back-to-basics approach and what this looks like, and what meaningful, transparent communication should look like in the new normal. Thum also delves into how individual lawyers can better advocate for themselves in evolving workplaces, making changes to the organisational mindset, building new communication strategies upon a foundation of respect and trust, the challenges that legal workplaces may face in undergoing such a realignment, and why the legal profession needs to see the Right to Disconnect laws as a “moment for potential growth”, and employ empathy in a technologically driven world. To learn more about The College of Law, click here.

„Deutsche Wirtschaft in der Flaute“, schreibt die Taz und die FAZ warnt im Juli 2023 „Der deutsche Wohlstand sei in Gefahr“. Auf YouTube sprießen aus allen Ecken Selbsternannte Finanzexperten empor, die uns erzählen wollen, wie wir binnen weniger Tage ein Vermögen erschöpfen und der Inflation entgehen könnten – man brauche nur die richtige Methode Oder […] Der Beitrag Wirtschaft im Wahlkampf. Ein Gespräch mit Ifo-Leiter Professor Dr. Marcel Thum erschien zuerst auf Campusradio Dresden.

Sioux Falls Police Chief Thum hopes to learn more about the recent shootings and homicides in our city. Plus other police issues that question the safety of residents in the Sioux Falls Metro.See omnystudio.com/listener for privacy information.

One of the most beautiful voices in CCM history belongs to one of the most beautiful people I've ever met on my musical journey. Pam Thum grew up with parents who were traveling evangelists and carried their heart for seeing people meet Jesus into her solo career. It's been way too long since she and I had the chance to talk, so sit back and relax as two old friends catch up on life and careers and tell a few fun stories along the way.Support the Show.andychrisman.com

Kutties (குட்டீஸ்)  Under the Tree is an initiative to promote book reading, the stories are told in Tamil language for the children to motivate them to read Tamil

Achtsamkeitspraxis ist auch wichtig für unsere Darmgesundheit. Denn: So wie unser Darm aussieht, so geht es auch unserem Gehirn.Hier geht's zum Podcast Seelenfänger vom BR.**********Quellen aus der Folge:Cryan, J. F., & Mazmanian, S. K. (2022). Microbiota–brain axis: Context and causality. Science, 376(6596), 938-939. Schneider, K. M., Blank, N., Alvarez, Y., Thum, K., Lundgren, P., Litichevskiy, L., ... & Thaiss, C. A. (2023). The enteric nervous system relays psychological stress to intestinal inflammation. Cell, 186(13), 2823-2838. Wang, Z., Liu, S., Xu, X., Xiao, Y., Yang, M., Zhao, X., ... & Wang, T. (2022). Gut microbiota associated with effectiveness and responsiveness to mindfulness-based cognitive therapy in improving trait anxiety. Frontiers in cellular and infection microbiology, 12, 719829. Darmfreundliche Ernährung**********Dianes und Main Huongs Empfehlungen:Axt-Gadermann, M. (2022). Gesund mit Darm. Fitter, gelassener und jünger mit dem richtigen Mikrobiom. Südwest. **********Mehr zum Thema bei Deutschlandfunk Nova:Ikigai: Wie wir Sinn und Zufriedenheit im Leben findenPsychotherapie: Das "innere Kind" in den Arm nehmenGartenarbeit: Draußen im Grünen sein ist Achtsamkeit**********Den Artikel zum Stück findet ihr hier.**********Ihr könnt uns auch auf diesen Kanälen folgen: Tiktok und Instagram.**********Ihr habt Anregungen, Ideen, Themenwünsche? Dann schreibt uns gern unter achtsam@deutschlandfunknova.de

[PODYSSEY] Die Bestimmung (Rolf Thum|Verena Wilhelmy)

[PODYSSEY] PC (Rolf Thum|Katrin Exner)

[PODYSSEY] Die Bestimmung (Rolf Thum|Verena Wilhelmy)

[PODYSSEY] PC (Rolf Thum|Katrin Exner)

Sioux Falls Police Chief Thum drops in on The Greg Belfrage Show. See omnystudio.com/listener for privacy information.

Ih Homone Te A Balance Theih Nang // Health Talk.Kawikawi + Aw Nem // Chin Gospel SOngs.

Ih pumpi ii ong hilh kholh Signs te thu // Health talk.Kawikawi + Pai Zel Ding // Chin Gospel Songs.

I am joined by Dr Yau Thum from the Lister to discuss Reproductive Immunology. Reproductive Immunology looks at how the immune system and the reproductive system can impact conception and pregnancy. It is an area that is explored and tested when people have experienced repeat implantation failure and/or miscarriage with no other explanation found. Dr Yau Thum leads the reproductive immunology research team at The Lister Fertility Clinic. He has been involved in research in the area of natural killer cells and immunological aspects of recurrent failed implantation since 2003 and have published papers demonstrating that an "overactive" immune system may negatively affect pregnancy outcomes and IVF success rates. In this episode we discuss: What is reproductive immunology? The problem with researching this area. What tests can you do to test this area? Killer cells what they are, how you test for them? What the cytotoxicity test is. Drug protocols to address these issues and when to start them Who should take the tests. Why they are so expensive. Where to find out more about reproductive immunology. If you want to learn more please see The Lister Fertility Clinic Pages and/or the Reproductive Immunology Centre. You can also find out more via HFEA

Bert sits down with a couple important people from our area, Sioux Falls' police and fire chiefs this hour to talk what's new within the respective departments, and also get a few bold big game predictions!

Sioux Falls Police Chief Thum drops in on The Greg Belfrage Show.See omnystudio.com/listener for privacy information.

This episode is set to inspire the structure of your marketing team, whether small, medium or colossal. Our guest, Eric Thum, Head of Marketing at VTS, was a winner of our FINITE 30 this year as he has led the marketing for one of the fastest-growing B2B SaaS companies in 2023. You'll get an inside scoop into how he's achieved this - through an integrated team structure, aligned metrics and more. The FINITE Podcast is made possible by:- Clarity: the fast growing, global marketing communications agency working with leading technology brands.- 93x: the leading digital marketing agency for B2B technology, software & SaaS businesses delivering SEO & PPC strategy that drives leads, pipeline & revenue growth.- And Exclaimer: the industry's leading provider of email signature solutions, empowering businesses to unlock the potential of email as a key digital advertising channel. Support the show

Matthew is here! Yes. He is back! Anotha one! Matthew starts off slow but finishes with a BANG! He talks about how the big toe doesn't have a unique name like the thumb, his trip to netherlands in a week, and much much more! Zip Zappity Doo! Love you if you listen. For real.

Substantiv

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2023.03.01.530580v1?rss=1 Authors: Singh, S., Gaur, A., Kumari, R., Prakash, S., Kumari, S., Chaudhary, A. D., Sharma, R. K., Prasun, P., Pant, P., Thum, T., Jagavelu, K., Bharati, P., Hanif, K., Chitkara, P., Kumar, S., Mitra, K., Gupta, S. K. Abstract: Regulation of RNA stability and translation by RNA-binding proteins (RBPs) is a crucial process altering gene expression. Musashi family of RBPs comprising Msi1 and Msi2 are known to control RNA stability and translation. However, despite the presence of MSI2 in the heart, its function remains entirely unknown. Here, we aim to explore the cardiac functions of MSI2. We confirmed the presence of MSI2 in the adult mouse, rat heart, and neonatal rat cardiomyocytes. Furthermore, Msi2 was significantly enriched in the heart's cardiomyocyte fraction. Next, using RNA-seq data and isoform-specific PCR primers, we identified, Msi2 isoforms 1, 4, and 5 and two novel putative isoforms labeled as Msi2 isoforms 6 and 7 to be expressed in the heart. Overexpression of Msi2 isoforms led to cardiac hypertrophy in cultured cardiomyocytes. Additionally, Msi2 was also found to be significantly increased in a pressure-overload model of cardiac hypertrophy. To validate the hypertrophic effects, we selected isoforms 4 and 7 due to their unique alternative splicing patterns. AAV9-mediated overexpression of Msi2 isoforms 4 and 7 in murine hearts led to cardiac hypertrophy, dilation, heart failure, and eventually early death, confirming a pathological function for Msi2. Using global proteomics, gene ontology, transmission electron microscopy, and transmembrane potential measurement assays increased MSI2 was found to cause mitochondrial dysfunction in the heart. Mechanistically, we identified Cluh and Smyd1 as direct downstream targets of Msi2. Overexpression of Cluh or Smyd1 inhibited Msi2-induced hypertrophy and mitochondrial dysfunction in cardiomyocytes. Collectively, we show that Msi2 induces hypertrophy, mitochondrial dysfunction, and heart failure. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Guh leh tang nat na nop tuam na ding // Health talk.Kawikawi + Tang thu ngaih pen // Chin Gospel Songs.

Gil sung a ih thau te kiam na ding // Health talk.Kawikawi + It huai Topa // Chin Gospel Songs.

Link to bioRxiv paper: http://biorxiv.org/cgi/content/short/2022.12.19.521052v1?rss=1 Authors: Mancini, N., Thoener, J., Tafani, E., Pauls, D., Mayseless, O., Strauch, M., Eichler, K., Champion, A., Kobler, O., Weber, D., Sen, E., Weiglein, A., Hartenstein, V., Thum, A. S., Rohwedder, A., Schleyer, M., Gerber, B. Abstract: Larvae of the fruit fly Drosophila melanogaster are a powerful study case for understanding the neural circuits underlying behavior. Indeed, the numerical simplicity of the larval brain has permitted the reconstruction of its synaptic connectome, and genetic tools for manipulating single, identified neurons allow neural circuit function to be investigated with relative ease and precision. We focus on one of the most complex neurons in the brain of the larva (of either sex), the GABAergic anterior paired lateral neuron (APL). Using behavioral and connectomic analyses, optogenetics, Ca2+ imaging and pharmacology, we study how APL affects associative olfactory memory. We first provide a detailed account of the structure, regional polarity, connectivity, and metamorphic development of APL, and further confirm that optogenetic activation of APL has an inhibiting effect on its main targets, the mushroom body Kenyon cells. All these findings are consistent with the previously identified function of APL in the sparsening of sensory representations. To our surprise, however, we found that optogenetically activating APL can also have a strong rewarding effect. Specifically, APL activation together with odor presentation establishes an odor-specific, appetitive, associative short-term memory, whereas naive olfactory behavior remains unaffected. An acute, systemic inhibition of dopamine synthesis as well as an ablation of the dopaminergic pPAM neurons impair reward learning through APL activation. Our findings provide a study case of complex circuit function in a numerically simple brain, and suggest a previously unrecognized capacity of central-brain GABAergic neurons to engage in dopaminergic reinforcement. Copy rights belong to original authors. Visit the link for more info Podcast created by Paper Player, LLC

Tom's guest is a friend who recently began his second year as the Chief of Police in Sioux Falls. Jon Thum is a husband, a father and a follower of Christ who has devoted his life to serving the public through law enforcement.In this episode of The RESGEN Giving Life Podcast, Tom and Jon discuss how his faith influences how he leads the police department and ways that citizens can encourage local police officers. They also discuss what churches and individuals can do to help those who are coming out of prison and how he personally processes movements like ‘defund the police'.The Giving Life Podcast: Conversations about being a man whose life in Christ gives life to others.Watch the video version on youtube - youtu.be/8Uta32UKrkoMore info about Restoration Generation - www.resgen.org

Happy Monday! Nan tho tha hna maw? CEBC Podcast, Zumhtlak Saltha in Morning Devotion tuah ti dingin kan in sawm hna. A kan hruaitu: Rev. Dr. Van Bawi Kam Tlangtar: Minung Dir Hmun Phun Thum Nan zate Bawipa nih thluachuah in pe hna seh, Amen! CAPT, Zumhtlak Saltha. -- Music by Peder B. Helland

Vaney sat down with Sioux Falls Police Chief Jon Thum to talk community, work, and how the two tie together.

Happy Monday! Nan tho tha hna maw? CEBC Podcast, Zumhtlak Saltha in Morning Devotion tuah ti dingin kan in sawm hna. A kan hruaitu cu CEBC kan Pastor John Za Thleng a si i Pathian Sinak Phun Thum timi tlangtar in a si lai. Nan zate Bawipa nih thluachuah in pe hna seh, Amen! CAPT, Zumhtlak Saltha. -- Music by Peder B. Helland

In the study of 19th and 20th century Chinese history, there is often focus on the intense Christian missionary activities happening in China. Yet at the same time, members of China's Hui (or Sino-Muslim) community were also beginning to reconnect with their co-religionists overseas. Armed with knowledge of Arabic, Persian, and Urdu and trained in Western orientalist discourses in new religious schools overseas, these Hui scholars began to "rediscover" aspects of Islam and in the process rewrite the history of Islam in China both for audiences within China and for a non-Chinese audience overseas. In this episode, we are joined by Professor Nile Green of UCLA to talk about how and why these exchanges took place and some of the implications of these exchanges. Please also be sure to check out Professor Green's podcast "Akbar's Chamber" for monthly episodes on the history of Islam. Available on Apple Podcasts and all other major podcast platforms. Contributors Professor Nile Green Professor Nile Green is a Professor of History and the Ibn Khaldun Endowed Chair in World History at UCLA. He works on the Islamic history of Asia, the Middle East, Africa and Europe, publishing numerous monographs and articles and editing seven books on a wide range of topics related to the history of Islam. His recent research interest is on the global history of Islam and Muslims, focusing on intellectual and technological interchange between Asia and Europe; Muslim global travel writings; the transnational genealogy of Afghan modernism; and the world history of 'Islamic' printing. He was a founding director of UCLA's Program on Central Asia and serves on many association and editorial boards. He is also the host of Akbar's Chamber, a podcast that offers a non-political, non-sectarian and non-partisan space for exploring the past and present of Islam. Yiming Ha Yiming Ha is a Ph.D. candidate in the Department of History at the University of California, Los Angeles. His current research is on military mobilization and state-building in China between the thirteenth and seventeenth centuries, focusing on how military institutions changed over time, how the state responded to these changes, the disconnect between the center and localities, and the broader implications that the military had on the state. His project highlights in particular the role of the Mongol Yuan in introducing an alternative form of military mobilization that radically transformed the Chinese state. He is also interested in military history, nomadic history, comparative Eurasian state-building, and the history of maritime interactions in early modern East Asia. He received his BA from UCLA and his MPhil from the Hong Kong University of Science and Technology. Credits Episode no. 9 Release date: March 13, 2022 Recording location: Los Angeles, CA Bibliography courtesy of Professor Green Images Cover Image: Masjid at the Aligarh Muslim University (formerly Muhammadan Anglo-Oriental College) in Aligarh, Uttar Pradesh, India. It was founded by Sir Thomas Arnold and was (and still is) a major center of Islamic learning (Image Source). A view of the Darul Uloom Nadwatul Ulama in Lucknow, India, an Islamic seminary where Hai Weiliang* studied (Image Source). Sir Thomas Walker Arnold (1864-1930), a renowned British orientalist and Islamic scholar who wrote the famous The Preaching of Islam and The Encyclopedia of Islam. He founded the Muhammadan Anglo-Oriental College (now Aligarh Muslim University) and taught Syed Sulaiman Nadvi, who was the teacher of Hai Weiliang (Image Source). Syed Sulaiman Nadvi (1884-1953), the teacher and educational patron of Hai Weiliang (Image Source). * Sadly, no pictures of Hai Weiliang can be found. References Green, Nile. How Asia Found Herself: A Story of Intercultural Understanding. New Haven: Yale University Press, forthcoming 2022. Benite, Zvi Ben-Dor. The Dao of Muhammad: A Cultural History of Muslims in Late Imperial China. Cambridge, MA: Harvard University Asia Center, 2005. Benite, Zvi Ben-Dor. “Taking ʿAbduh to China: Chinese-Egyptian Intellectual Contact in the Early Twentieth Century.” In James Gelvin and Nile Green (eds.), Global Muslims in the Age of Steam and Print, edited by James Gelvin and Nile Green, 249-267. Berkeley: University of California Press, 2014. Chen, John. “‘Just Like Old Friends': The Significance of Southeast Asia to Modern Chinese Islam.” SOJOURN: Journal of Social Issues in Southeast Asia 31, no. 3 (2016): 685–742. Chen, John. “Islam's Loneliest Cosmopolitan: Badr al-Din Hai Weiliang, the Lucknow-Cairo Connection, and the Circumscription of Islamic Transnationalism.” ReOrient: The Journal of Critical Muslim Studies 3/2 (2018): 121-139.  Chung, Tan & Ravni Thakur (eds). Across the Himalayan Gap: An Indian Quest for Understanding China. New Delhi: Indira Gandhi National Centre for the Arts, 1998. Henning, Stefan. “God's Translator: Qu'ran Translation and the Struggle over a Written National Language in 1930s China.” Modern China 41, no. 6 (2015): 631-655. Jahn, Karl. China in der islamischen Geschichtsschreibung. Vienna: Österreichischen Akademie der Wissenschaften, 1971. Lipman, Jonathan N.  Familiar Strangers: A History of Muslims in Northwest China. Seattle: University of Washington Press, 1997. Mao, Yufeng. “A Muslim Vision for the Chinese Nation: Chinese Pilgrimage Missions to Mecca during World War II.” The Journal of Asian Studies 70, no. 2 (2011): 373–395. Murata, Sachiko. “The Muslim Appropriate of Confucian Thought in Eighteenth-Century China.” Comparative Islamic Studies 7, no. 1-2 (2012): 13–22. O'Sullivan, Michael. “Vernacular Capitalism and Intellectual History in a Gujarati Account of China, 1860–68.” The Journal of Asian Studies 80, no. 2 (2021): 267–292. Park, Hyunhee. Mapping the Chinese and Islamic Worlds: Cross-Cultural Exchange in Pre-Modern Asia. Cambridge: Cambridge University Press, 2012. Petersen, Kristian. Interpreting Islam in China: Pilgrimage, Scripture, and Language in the Han Kitab. Oxford: Oxford University Press, 2017. Sen, Tansen. India, China, and the World: A Connected History. Lanham: Rowman & Littlefield, 2017. Thum, Rian. The Sacred Routes of Uyghur History. Cambridge MA: Harvard University Press, 2014.

Dennis Thum is a husband, father, and grandfather, who has invested over 30 years of his life into the lives of thousands of college students as the campus pastor of the University of Sioux Falls.  On this episode of The Giving Life Podcast, Tom and Dennis discuss some of the most significant changes he has seen in college students over the last three decades, how men can wrestle with and figure out the role they are to play in God's Kingdom and what he is doing to finish strong in the race God called him to run. They also talk about a topic that the church doesn't deal with very well – divorce – and what he learned about himself, the Church and the Lord as he journeyed through his own experience with it.The Giving Life Podcast: Conversations about being a man whose life in Christ gives life to others.Watch the video version on youtube - youtu.be/1S6M20pCbe4 More info about Restoration Generation - www.resgen.org

God is taking us through a season where we need to be awake and we need to rise up in maturity. - Grow in maturity in the Word of God and in the power of the Holy Spirit. - Let's arise and seek God!

Make way for BIG Tracy and Rachel energy in this episode as they are completely honored and wildly enthused to be joined by Sioux Falls Police Chief Jon Thum. Chief Thum brings his signature character and integrity to the conversation as he discusses a worldview and a law enforcement approach that is both empathetic and respectful and one that seeks to restore dignity of all parties involved. Along the way he emphasizes the importance of bridge-building among the city's many communities, agencies, and leaders and commends Sioux Falls as being a leader in such collaboration. Tracy and Rachel learn that the road to becoming chief of police does not, in fact, involve the use of campaign yard signs, while Chief Thum reminds Rachel of their shared past in middle school youth ministry. While promoting Novem-burn, the city's fundraiser and awareness campaign for Operation Hope, Chief Thum acknowledges the timeless fashion influence of Beverly Hills 90210 on his own personal look and reveals the fateful day his signature sideburns were bested by his grandmother and a pair of clippers. He also explains how a past stint as the University of Sioux Falls Choir Chaplain led to a devotional about which light to follow, an anecdote that points back to his own decision to change course from an early career in business to pursue a calling to a life of service. Lastly, Chief Thum and Tracy feel kinship over their shared love of Mexican food and Rachel and Tracy unabashedly and, of course, enthusiastically invite Chief Thum back to a be a regular guest. Episode Mentions: Novem-burn for Hope Fundraiser: https://www.argusleader.com/story/news/2021/11/04/sioux-falls-police-chief-sideburns-fundraiser-novemburn-operation-hope-movember/6272739001/ Operation Hope: https://www.sfacf.org/news/operation-hope-fund-to-help-improve-continuum-of-care The Link: https://www.linksf.org/ Sioux Falls Police Department: https://www.siouxfalls.org/police Beverly Hills 90210 Sideburns: https://www.today.com/style/luke-perry-s-sideburns-are-part-what-made-him-star-t149807 Giliberto's Mexican Taco Shop: https://gilibertos.com Abelardo's Mexican Fresh: http://www.abelardosmexicanfood.com Azteca Family Restaurant: http://www.azteca-sd.com Jacky's Restaurant: http://www.jackysrestaurants.com Inca Authentic Mexican Restaurant: http://www.incamexicanrestaurantsf.com Morrie's Steakhouse: https://www.morriessteakhouse.com Chick-fil-A Sioux Falls: https://www.chick-fil-a.com/locations/sd/empire-place-sd

Die Begriffe DNA und RNA kennen viele Menschen schon aus dem Biologieunterricht. Dass RNAs auch als Wirk- und Impfstoffe eingesetzt werden können, war vor der Corona-Pandemie jedoch den wenigsten bekannt. Aber was genau steckt dahinter? Weiß auch jeder, welche Eigenschaften Ribonukleinsäure hat und warum gerade RNA-Moleküle die Entwicklung eines Impfstoffs gegen COVID-19 in ungewöhnlich kurzer Zeit ermöglicht haben? In der Wissenschaft ist das Potenzial von RNAs schon seit 30 Jahren kein Geheimnis mehr. Doch nicht nur in der Impfstoffentwicklung spielt die RNA-Forschung eine Rolle. 00:00 Hoffnungsträger RNA 01:29 Was ist RNA? 02:16 Wie funktioniert RNA? 03:18 Was ist mRNA, MessengerRNA? 04:42 Wie lässt sich RNA gegen Krankheiten einsetzen? 07:07 Die Hoffnungen in RNA sind berechtigt 08:29 RNA universell einsetzbar 10:03 Grundlagenforschung und angewandte Forschung 12:01 RNA gegen Krebs und Herzkreislauferkrankungen 16:14 Translation und automatisierte Medikamentenentwicklung Prof. Dr. Dr. med. Thomas Thum, Institutsleiter des Fraunhofer-Instituts für Toxikologie und Experimentelle Medizin ITEM (Hannover), arbeitet mit so genannten miRNAs – nicht-kodierenden RNA-Molekülen, deren Rolle bis vor einigen Jahren noch völlig unklar war. Mit seinem Team hat er neue therapeutische Angriffspunkte identifiziert und darauf aufbauend RNA-basierte Therapien für Patienten mit Herzinsuffizienz entwickelt und diese bereits erstmals klinisch erprobt. miRNAs haben großes Potenzial für die Entwicklung neuer diagnostischer Biomarker und Therapien – nicht nur für Herz-Kreislauf- sondern auch viele andere Erkrankungen. Warum die RNA-Forschung nicht nur Hoffnungsträger für den medizinischen Fortschritt, sondern gleichzeitig ein hervorragendes Beispiel für die Translation vom Labor zur Therapie ist, erläutert Prof. Thum im Fraunhofer-Podcast. Der mit dem Paul-Martini-Preis ausgezeichnete Kardiologe forscht seit Jahren an Therapien mit Hilfe von RNA und hat diese bereits erfolgreich gegen Herzinsuffizienz eingesetzt. FuE-Schwerpunkte von Prof. Thomas Thum https://www.item.fraunhofer.de/de/angebot/neue-institutsleitung-fraunhofer-item-2021.html Prof. Thum erhält Paul-Martini-Preis Neue Behandlung bei chronischer Herzschwäche: Institutsleiter des Fraunhofer ITEM erhält Paul-Martini-Preis 2021 https://www.item.fraunhofer.de/de/presse-medien/presseinformationen/institutsleiter-thum-erhaelt-paul-martini-preis-2021.html Website Fraunhofer ITEM https://www.item.fraunhofer.de/

Saipi bang in lam pai in // Health talk.Kawikawi + Samaria tui khuk // chin gospel songs.

In this episode, Adam and Steve learn all about Thum from owner Darleen Vanmanivong. Her passion and love for food is inspiring. Located in Crossroads Collective in Milwaukee's welcoming East Side neighborhood, Thum launched in the middle of the pandemic and is doing so well that Darleen recently committed to another two years. Learn more about how she and Thum got started, what family meal means, what to pair with Thum dishes, and some secret hidden Milwaukee gems to experience.

Huih lah ah taih inn lam te // Health talk.Kawikawi + Tang thu mngaih pen // chin gospel songs.

"Lục Thum" nghĩa là "ông lớn". Người Khmer dùng từ này để gọi những cán bộ cao cấp. Tuy Võ Đình Chiến, chỉ là một y tá quèn trong đơn vị, nhưng trong mắt người dân Khmer ở Choăm-Sre thì anh như một "Ông Lớn" chân chính.. Xem chi tiết: https://khamphalichsu.com/luc-thum-vo-dinh-chien-tu-y-ta-nhay-len-lam-bac-sy-phu-san-n143.html

Bang te in gil pi gim sak hiam // Health talk.Kawikawi + Khual zin mi // chin gospel songs.

The cuisine of Laos is currently having its moment in cities throughout the U.S. That’s thanks, in large part, to a new crop of young chefs who’ve made it their mission to highlight the bold, vibrant flavors of Lao fare, a cuisine which has all-too-often been eclipsed by dishes from their (larger) neighboring countries of Thailand, Vietnam and China. Among those young chefs is Darleen Vanmanivong, an industry veteran who spent nearly a decade cooking food for other chefs before branching out to start her own restaurant, Thum.On this week’s podcast, we chat with Vanmanivong about the food she grew up eating, the grandmother who inspired her desire to share her culture and the philosophy with which she approaches her food. Along the way, we diverge to discuss a variety of food-related topics, from whole animal butchery (and items like fish eyeballs) to the flatulent secrets of sunchokes.

Wendy Goodman Thum is the Chairwoman of Beautification for the Neighborhood Council of Sun Valley, CA.

I spoke with Thum "PJ" Ping Tjin, the founder of New Naratif, on how colonialism and capitalism have shaped Singapore's past, present and future. We also discuss the history of Dissent in Singapore and why voices like PJ's are rising to critique the political and economic elites of the country. For more please check out New Naratif: it's one of the finest sources of news and analysis in Asia: https://newnaratif.com/ And specific to Singapore's history, this article by PJ is a master piece in explaining how colonialism infects Singapore's current political imagination: https://newnaratif.com/research/justifying-colonial-rule-in-post-colonial-singapore/ And recently New Naratif and PJ have personally been harassed by Singapore's government. To demand the Singapore Government stop harassing Free Press in Singapore go here: https://newnaratif.com/new-naratif-under-attack/ Beat - "Groove with Me" - Prod. Nikos: https://www.youtube.com/watch?v=abx1OfQkO1Y

Welcome to HMSC Connects! where Jennifer Berglund goes behind the scenes of four Harvard museums to explore the connections between us, our big, beautiful world, and even what lies beyond.For our fourth and final episode celebrating the Women's Suffrage Centennial this month, Jennifer is speaking with Jen Thum, the Assistant Director of Academic Engagement, and the Assistant Research Curator at the Harvard Art Museums. She's an archaeologist and a specialist in the art and archaeology of ancient Egypt.

07.22.20 Wednesday - Patty Prather Thum by Think Humanities

HDVDL TAKE OVER mit Noëmi Thum (Director) - die Influencerin und Autorin, Carmen Segattini, hat klangheimlich den Podcast übernommen und mit ihr über den Job im Sales und Vertrieb, Klischees gegenüber Frauen, Leistungsdruck, Cold Calling, Kundenbedürfnisse, Erfolg, Motivation, Selbstdisziplin, die Work-Life-Balance, Zeitmanagement, Lernprozesse, Neugierde, Empathie als Erfolgsfaktor, Erwartungshaltungen, Selbstsorge, den ständigen Drang nach Optimierung, Perfektionismus, das Growth Mindset, Herausforderungen, ambitionierte Ziele, Belastbarkeit, den Umgang mit Beschwerden, Kundenbindung, Ehrlichkeit, Dankbarkeit und vieles mehr gequatscht! instagram: hdvdl_podcast

Nau paai na leh nunun gah // Health talk.Kawikawi + Nang kong zuan hi + Zeisu khut len in // chin gospel songs.

June marks 40 years of IVF and I had the pleasure of speaking with the 1st generation of IVFlings*. I caught up with Candice Thum Nèe Reed Australia's first IVF baby, born in June 1980. She is a former journalist turned community developer and a mother of two children. Married to a Kiwi she now lives in Auckland and Rebecca Featherstone Jelen conceived at Bourn Hall in England, where the world's first IVF baby was conceived. Rebecca juggles a busy Sydney life with her two children. After a career in artist and event management, she recently completed further study and now works with IVF Australia. It's incredible how much has changed since then, today we discuss what it was like growing up as an IVF baby, navigating teenage years and high school and dealing with awkward questions. Together Candice and Rebecca are ideally placed to advocate for change in fertility health education and awareness having lived it all their lives. They are approachable and relatable to all walks of life and since they are not fertility specialists they do not scare people aware by using industry jargon. Candice and Rebecca make a formidable team and often joke they were literally made to be friends! If you like to discuss topics in today's episode and like to contact Candice and Rebecca please head to their social platform. Website https://www.fertilitymatters.org.au/ Facebook https://www.facebook.com/fertilitymatters15/ Instagram https://www.instagram.com/fertilitymatters/?hl=en *a term meaning anyone conceived through fertility treatment to refer to themselves.

Fratz A. Thum, geboren 1967 in einem kleinen katholischen Kaff in Bayern bekam 1980 die erste Platte der Band „Hass“ in die Finger und danach war nichts mehr wie vorher. Bereits Mitte der 80er Jahre begann er Konzerte zu organisieren und Platten zu tauschen. 1986 zog er mit seiner Plattenkiste von Gig zu Gig und gründete mit Hulk ConnAction den Vorgänger von Hulk Räckorz. 1988 traf er auf Axel Kurth, die beiden verstanden sich gut und Fratz begann, Touren für Axels Band WIZO zu buchen und brachte die erste Veröffentlichung auf dem neu gegründeten Label Hulk Räckorz raus (der Rest ist Geschichte). Über die Jahre folgten viele weitere WIZO-Veröffentlichungen und Touren in Deutschland, Ungarn, Japan, Frankreich, England, Amerika, Canada. Von 1994 bis 1996 spielte Fratz Bass bei der Regensburger Band Use To Abuse, die seinen Lebensweg immer mal wieder kreuzt und auch mehrere Platten auf Hulk Räckorz rausbringt. Bereits 1996 holte er sich die Domain www.punk.de wo man WIZO Merch bestellen konnte. 2005 organisierte Fratz die WIZO-Abschiedstour. Danach gings aus Bayern in den Ruhrpott, genauer gesagt nach Gladbeck. In diesem Jahr gab er ein kurzes Intermezzo bei Rasta Knast am Bass bevor er 2007 die Band Rockwohl Degowski gründete. Zwischendurch stampften Fratz mit inzwischen Ehefrau Vera Vandal die Modemarke Sexypunk aus dem Boden. 2008 wird der Shop auf punk.de gelauncht, wie er jetzt ist, sodass jeder Platten, e-Tickets oder mp3s verkaufen kann. 2009 organisierten Fratz und Axel die WIZO Reunion, die seitdem mit einer umfangreichen Tour alle zwei Jahre durch die Republik und angrenzende Länder führt. Mittlerweile ist er Vater zweier Kinder und sieht sich als Berufsjugendlicher. „Für mich war es ein Befreiungsschlag ins Ruhrgebiet zu kommen. Die Menschen sind hier viel herzlicher und weniger mit dem Ellenbogen unterwegs, als in Bayern.“ Fratz ist überzeugt, dass das Ruhrgebiet riesiges Potenzial hat: „Eigentlich ist es eine Metropole, wo Berlin und Hamburg gar nicht hinstinken können.“ Für ihn ist das Ruhrgebiet ein Freizeitparadies geworden. Aktuell spielt er u.a. Bass bei der Punk-Rock-Band „Kupferwerk Gold“. Weitere Info: www.punk.de www.ruhrpodcast.de www.durian-pr.de

This episode, the guys welcome movie composers Max Aruj and Steffen Thum to the show to discuss their work, their influences, and their brilliant score for Crawl. Oh, and we talk about The Invisible Man some more.Learn more about Max and Steffen at their websites:https://www.maxaruj.comhttps://www.steffenthum.com

In newest installment of our alumni series, Paul and Audrey chat with Dr. Jasmine Thum. Dr. Thum received her BS and MS in biomedical engineering at USC in just four years, then went on to Harvard Medical School to receive her MD. Currently Dr. Thum is in the Nurological Surgery Residency Program at UCLA. Tune in to hear this incredible story combining medicine and engineering.

Esorgi Sen thum phajana sijinnarabadi blessing yamna phangani.

Steffen Thum arbeitet seit fünf Jahren in Hollywood im Team von Lorne Balfe und hat schon an der Filmmusik für Mission Impossible, Gemini Man, Ad Astra und Dunkirk mitgearbeitet. In diesem Teil verrät er, was genau Additional Music heißt, welche Stems abgeliefert werden, wie viel Zeit er pro Film hat, was er bei Dunkirk gemacht hat und was seine Lieblings-VST-PlugIns sind.Die vorherigen Folgen sind 077 und 066.Fragen und Anregungen an sounthcast@sounth.deNewsletter abonnieren: http://eepurl.com/dJaBMDSpotify: https://open.spotify.com/show/5VSIxSdavASHfETN64Ow8IFacebook-Gruppe: https://www.facebook.com/groups/309751689699537/

Steffen Thum arbeitet seit fünf Jahren in Hollywood im Team von Lorne Balfe und hat schon an der Filmmusik für Mission Impossible, Gemini Man, Ad Astra und Dunkirk mitgearbeitet. In diesem Teil verrät er Details zur Produktion von 'Mission Impossible', ob er in 5.1 oder stereo mischt, Kontakt-Instrument in 5.1 programmieren und warum bei 'Ad Astra' nicht klar war, welche Musik zu hören ist.Folge 1 mit Steffen ist Episode 66 in diesem Podcast. Fragen und Anregungen an sounthcast@sounth.deNewsletter abonnieren: http://eepurl.com/dJaBMDSpotify: https://open.spotify.com/show/5VSIxSdavASHfETN64Ow8IFacebook-Gruppe: https://www.facebook.com/groups/309751689699537/

God is a caring, loving and compassionate Father and He loves us more than we will ever understand.

This guy's crazy. Listen up though weird ENGLISH don't mind. Cheers --- This episode is sponsored by · Anchor: The easiest way to make a podcast. https://anchor.fm/app --- Send in a voice message: https://anchor.fm/ikea-shammacher/message

Steffen Thum arbeitet seit fünf Jahren in Hollywood im Team von Lorne Balfe und hat schon an der Filmmusik für Mission Impossible, Gemini Man, Ad Astra und Dunkirk mitgearbeitet. Im diesem Teil verrät er, wie er seine Karriere begann, ob sich die Musik nach dem Schnitt richtet oder umgekehrt und ob der ganze Film in einem Projekt angelegt wird oder jede Szene ein eigenes Projekt bekommt. Außerdem reden wir über seine Filmmusik zu Crawl und Steffen verrät, wie der Anfangs-Sound kreiert wurde. Hier kannst Du die Musik hören, über die wir sprechen. 1. https://open.spotify.com/track/3PwxE0hU6Fo1hIV92IzFEM?si=kD3FbS-DRJW03WT2s7uC4A   2.https://open.spotify.com/track/1fguMLLjbbX8TMBIEiJKmT?si=yxHTLxZ_Ssi5fq8jy8uX2w   Fragen und Anregungen an sounthcast@sounth.deNewsletter abonnieren: http://eepurl.com/dJaBMDSpotify: https://open.spotify.com/show/5VSIxSdavASHfETN64Ow8IFacebook-Gruppe: https://www.facebook.com/groups/309751689699537/

Der Wiener Beinschinken hat Tradition. Bereits seit 160 Jahren steht der Name Thum für feinsten handgemachten Schinken. Ich spreche mit dem Schinkenspezialisten und Fleischhauer Roman Thum darüber, was einen guten Schinken auszeichnet und wie er gemacht wird. Seine durch die Familientradition geprägte Unternehmens-Philosphie, Slow Food und darüber, dass wir alle zu viel Fleisch essen. --- Send in a voice message: https://anchor.fm/kuechenfreundin-Isi/message

Generalisten – sie können, alles aber nichts richtig, heißt es oft. Welche Vorteile das mit sich bringt, welche Spezialitäten ein Generalist hat und was die "T-shaped education" mit dem Thema zu tun hat, erfahrt ihr in dieser Podcast-Folge.

We talk about where the field was and where it is now heading.

Viral beatboxer Tom Thum has an orchestra in his mouth, but how does he make all those sounds? Get an up-close-and-personal look as laryngeal surgeon Matthew Broadhurst sticks a camera down Thum's throat while he creates a mind-boggling array of noises. This hilarious, somewhat stomach-churning talk and performance is not for the squeamish! (Contains graphic medical imagery)

O beatboxer Tom Thum tem uma orquestra na boca, mas como ele faz todos esses sons? Veja de muito perto quando o cirurgião de laringe Matthew Broadhurst coloca uma câmera dentro da garganta de Thum enquanto ele cria uma série de sons surpreendentes. Esta palestra e apresentação hilária e um tanto desagradável não é para os sensíveis! (Contém imagens médicas explícitas)

Le beatboxer Tom Thum a un orchestre dans sa bouche, mais comment produit-il ces sons ? Un avis proche et personnel en tant que chirurgien du larynx Matthew Broadhurst introduit une caméra dans la gorge de Thum pendant qu'il crée une gamme de sons époustouflants. Ce discours hilarant et cette performance, au côté bouleversant, n'est pas adapté aux plus sensibles (De l'imagerie médicale est présente).

El cantante de beatbox Tom Thum tiene una orquesta en su boca, ¿pero cómo hace toda esa variedad de sonidos? Conozca de cerca esa respuesta cuando el otorrinolaringólogo Matthew Broadburst inserte una cámara dentro de la garganta de Thum mientras este emite ruidos alucinantes. ¡Una divertida y nauseabunda charla no apta para los delicados! (Contiene imágenes sensibles de carácter médico)

The year, 2019. It's been 50 years since man landed on the moon, and today the universe seems full of possibilities. From science done on the International Space Station to travelling to Mars, our guest today, Volker Thum, knows everything there is to know about space. He's the CEO of the German Aerospace Industries Association. In his role, he has to talk about some very technical and complicated topics. But not only does he love space, but he loves talking about it in ways everyone can understand. He lets us in on everything from negotiation tactics to dealing with contentious opinions on drones, as well as how technology can and does affect our daily lives as well as in the skies. On today's episode we ask ourselves: Why space? Why does it fascinate us? Why do we love it so much? And our guest says it best: it all comes down to our curious nature as well as our desire to explore what's out there. Enjoy!

Have you noticed all of these online courses, master classes, and tutorials that promise to help you get clients? They seems to be all that is in our instagram feed lately. "If you buy our APP you will become a better filmmaker!" "We have the secret to you finally being able to make money!" Mike gives his opinion on the recent rise of what he refers to as "snake oil salesman" that prey our your insecurities as an artist. He also talks with Taylor Thum, a talented film student that has to interview a working industry professional for her class assignment. They discuss film school, documentaries, on set experience and how to get solid filmmaking experience. Loaded with brutal honesty, this episode is a must for young filmmakers or students thinking about going to film school.

Ṣafar is the second month of the Islamic lunar calendar. There is a weak hadith narrated by Ibn ‘Abbās that states, “On the last Wednesday of the month [of Ṣafar] there is a continual calamity.” In other hadiths it is mentioned that this is the day during which Pharaoh and his army perished, and the people of ‘Ād and Thumūd were destroyed. Accordingly, there emerged from these texts various supplications and prayers to meet these historic, calamitous events with prayers and devotion.

InterBrews 170 was recorded at Baileson Brewing with owners Adam Cryer and Sarah Pope along with Cruizin Cooler owner Brian Thum as part of a get together pre-party for Liquid Lunch’s 100th episode on Saturday at Baileson Brewing. Host Josh Stewart, along with TD Mike Herrera and Producer Kennedy, sat down to discuss the big […]

I chat with the co-founder of THUM&THUM, Michael Sin with stories of our popups, his views on Chipotle, Hawaiian poi, and Tiffany Haddish's meet and eat with Taylor Swift!

Bourby Webster speaks to Gordon Hamilton - composer, conductor, radio producer and wearer of many hats. Hear about Perth Symphony's upcoming collaboration as part of the Red Earth Arts Festival in Karratha in September. Listen as Gordon explains how the 'Thum Prints' project came about with renowned beatboxer Tom Thum and how they worked together to compose these incredibly unique pieces.

On Episode 129 of InterBrews we welcome in Brian Thum. Brian Thum is the owner of Cruzin Cooler. Cruzin Coolers are badass motorized coolers you can drive. It’s also a Houston company. We talk to Brian about his company, his products and the beer we put in them. This is InterBrews. 

Dr. Carolyn Lam: Welcome to Circulation on the Run, your weekly podcast summary and backstage pass to the journal and its editors. I'm Dr. Carolyn Lam, associate editor from the National Heart Center and Duke National University of Singapore. Today we will be discussing the pooled analysis results of the 10 ODYSSEY Trials with important implications for the reduction of lipids in major cardiovascular events. But first, here's your summary of this week's journal. The first paper provides experimental data on vascular disease that brings into focus the critical roles of transcription factors such as GATA2 in the maintenance of endothelial cell function, as well as the role of selected microRNAs as a novel player of vascular regulation. In this study by first author Dr. Hartman, corresponding author Dr. Thum from Hanover Medical School, and colleagues, authors used GATA2 gain and loss of function experiments in human umbilical vein endothelial cells to identify a key role of GATA2 as a master regulator of multiple endothelial functions, and this via microRNA-dependent mechanisms. Global microRNA screening identified several GATA2-regulated microRNAs, including miR-126 and miR-221. GATA2 deficiency led to vascular abnormalities, whereas supplementation with miR-126 normalized vascular function. In a mouse model of carotid injury, GATA2 was reduced and systemic supplementation of miR-126-coupled nanoparticles enhanced miR-126 availability in the carotid artery and improved reendothelialization of injured carotid arteries in vivo. In summary, GATA2-mediated regulation of miR-126 and miR-221 has an important impact on endothelial biology. Thus, modulation of GATA2 and its targets miR-126 and miR-221 represents a promising therapeutic strategy for the treatment of vascular diseases. The next study is the first to show that current smokers from the general population have lower levels of circulating cardiac troponin I, a seemingly paradoxical observation given the known detrimental cardiovascular impact of cigarette smoking. First author Dr. Lyngbakken, corresponding author Dr. Omland, and colleagues from the University of Oslo used data from the large population-based HUNT study, in which cardiac troponin I was measured in 3,824 never smokers, 2,341 former smokers, and 2,550 current smokers. Current smokers had significantly lower levels of cardiac troponin I than never smokers and former smokers, an association that remains significant even after adjustment for potential confounders. The authors also found an association between increasing concentrations of troponin I and clinical endpoints, namely acute myocardial infarction, heart failure, and cardiovascular death in the total cohort. However, this association was attenuated in current smokers and was significantly weaker than in never or former smokers with a p for interaction of 0.003. The prognostic accuracy of troponin I as assessed by C-statistics was lower in current smokers than in never smokers. Troponin I provided no incremental prognostic information to the Framingham Cardiovascular Disease risk score in the current smokers. Together, these results suggest that mechanistic pathways other than those involving subclinical myocardial injury may be responsible for the cardiovascular risk associated with current smoking. Future studies are needed to determine whether a lower cardiac troponin I threshold should be considered for exclusion of myocardial infarction in smokers or whether prognostic tools other than measurement of cardiac troponins should be utilized when evaluating risk of future events in current smokers. The next study contributes to our understanding of cardiomyocyte signaling in response to ischemic injury. In the study by first author Dr. [Wool 00:05:04], corresponding author Dr. [Ju 00:05:04] from Tongji University School of Medicine in Shanghai, and colleagues, authors sought to understand the role of low-density lipoprotein receptor-related proteins 5 and 6 as well as beta-catenin signaling in the heart. They did this using conditional cardiomyocyte-specific knockout mice who had surgically induced myocardial infarction. They found that deletion of lipoprotein receptor-related proteins 5 and 6 promoted cardiac ischemic insults. Conversely, deficiency of beta-catenin, a downstream target, was beneficial in ischemic injury. Interestingly, although both insulin-like growth factor-binding protein 4 and Dickkopf-related protein 1 are secreted beta-catenin pathway inhibitors, the former protected the ischemic heart by inhibiting beta-catenin, whereas the latter enhanced the injury response mainly through inducing lipoprotein-related protein 5 and 6 endocytosis and degradation. These findings really add to our understanding of the beta-catenin signaling pathway in ischemic injury and suggests that new therapeutic strategies in ischemic heart disease may involve fine-tuning these signaling pathways. The next paper from the International Consortium of Vascular Registries is the first study allowing an assessment of variations in repair of abdominal aortic aneurysms in 11 countries over 3 continents represented by the Society of Vascular Surgery and European Society for Vascular Surgery. Dr. Beck from University of Alabama-Birmingham School of Medicine, and colleagues, looked at registry data for open and endovascular abdominal aortic aneurysm repair during 2010 to 2013, collected from 11 countries. These were Australia, Denmark, Hungary, Iceland, New Zealand, Norway, Sweden, Finland, Switzerland, Germany, and the United States. Among more than 51,000 patients, utilization of endovascular aortic repair for intact aneurysms varied from 28% in Hungary to 79% in the United States, and for ruptured aneurysms from 5% in Denmark to 52% in the United States. In addition to the between-country variations, significant variations were present between centers within each country in terms of endovascular aortic repair use and rate of small aneurysm repair. Countries that more frequently treated small aneurysms tended to use the endovascular approach more frequently. Octogenarians made up 23% of all patients, with a range of 12% in Hungary to 29% in Australia. In countries with a fee for service reimbursement systems, such as Australia, Germany, Switzerland, and the United States, the proportion of small aneurysms and octogenarians undergoing intact aneurysm repair was higher compared to countries with a population-based reimbursement model. In general, center-level variation within countries in the management of aneurysms was as important as variation between counties. Hence, this study shows that despite homogeneous guidelines from professional societies, there is significant variation in the management of abdominal aortic aneurysms, most notably for intact aneurysm diameter at repair, utilization of endovascular approaches, and the treatment of elderly patients. These findings suggest that there is an opportunity for further international harmonization of treatment algorithms for abdominal aortic aneurysms. This is discussed in an accompanying editorial entitled, Vascular Surgeons Leading the Way in Global Quality Improvement, by Dr. Fairman. The final paper from Dr. Gibson at Beth Israel Deaconess Medical Center and Harvard Medical School and colleagues, presents the results of the apoAI event reducing in ischemic syndromes I, or AEGIS-I, trial, which was a multicenter, randomized, doubleblind, placebo-controlled dose-ranging phase 2b trial of CSL112, which is an infusible, plasma-derived apoAI that has been studied in normal subjects and those with stable coronary artery disease, but now studied in the current study in patients with acute myocardial infarction. The trial showed that among patients with acute myocardial infarction, four weekly infusions of a reconstituted, infusible, human apoAI, CSL112, was associated with a dose-dependent elevation of circulating apoAI and cholesterol efflux capacity without adverse hepatic or renal outcomes. The potential benefit of CSL112 to reduce major adverse cardiovascular events will need to be assessed in an adequately powered phase 3 trial. Now for our future discussion. Today I am delighted to have with us Dr. Kausik Ray from Imperial College London, who's the first and corresponding author of a new paper regarding the pooled analysis of the 10 ODYSSEY Trials. To discuss it with us is Dr. Carol Watson, associate editor from UCLA. Kausik, just let me start by congratulating you on this paper. I believe this is the first data that allows us to look under the 50 mg/dL mark of LDL and really ask if the LDL MACE relationship extends below this level. Dr. Kausik Ray: Yes, the reason for looking at this is that the IMPROVE-IT trial really looked at people down to an average LDL cholesterol of about 54, and with the new PCSK9 inhibitors, which instead of giving you a 20% further reduction LDL, they give you the opportunity for a further 50 to 60% reduction. We actually get the chance to get people down to levels like 25 mg/dL, and the question is, does the benefit continue at that level? We did a pooled analysis of 10 of the ODYSSEY Trials, really in some ways to try and help predict what you might see in ODYSSEY outcomes, what you might see in the [Fuliay 00:12:00] trial, and to also manage expectations as well, because there's probably been a lot of hype around the two New England Journal papers about 50, 60% reductions of all potential reductions based on small numbers of events. So the question is, if you reduce LDL by 39 mg/dL, how might that reduce your risk, and is the relationship continuous? So those were the aims. Dr. Carolyn Lam: That's great, and maybe could you give us an idea of the number of patients you are looking at and the number of events? Dr. Kausik Ray: Yeah. In the 10 pool studies, we had just under 5,000 individuals, and we had just about 6,700 person years' worth of followup. In total, we had 104 first MACE events. To put this into context, it's about one third of the number of events that the first [framing 00:12:53] of analysis had. It's an observation analysis rather than randomized trial data, so you got to bear that in mind with the usual caveats that go with observational data. But the same endpoints that were adjudicated, this is [inaudible 00:13:10] heart disease death, non-fatal MI, ischemic stroke, and unstable angina requiring hospitalization. This is the same endpoint that is in the ODYSSEY Outcomes Trial, so it's interesting in that regard. Dr. Carolyn Lam: Yeah, it sure is. So what's the bottom line? What did you find? Dr. Kausik Ray: What we found was that there was a continuous relationship all the way down to LDL cholesterol levels of about 25 mg/dL, that every 39 mg/dL lower on treatment LDL, your risk went down by about 24%. If you looked at [apo-like 00:13:48] approaching be on non-HDL cholesterol, again, you found the same continuous relationship with a similar point estimate for a similar standardized difference in LDL cholesterol. We also looked at many of the guidelines, talk about percentage reduction. We actually looked at percentage reductions. If you start with a baseline LDL of X and you achieve a 50% further reduction in LDL, how much further benefit does that give you? A 50% further reduction gave you a 29% further lower risk of MACE. So we didn't find any threshold or limit all the way down to LDLs of about 25. Dr. Carolyn Lam: That's really a key, novel finding that you contributed, so congratulations once again. I suppose the question will always be, you're talking about relative risk reductions here. At such low levels, can you give us an idea of the absolute risk reductions? Dr. Kausik Ray: Yes. You've got to remember that the relative risk reductions are what you can apply to population differences. If you pick a high-risk patient population, you would expect to see a much bigger absolute risk reduction than maybe this study or another study. Similarly, if you pick a low-risk group, you are going to see a much smaller absolute benefit. I always try to advise a little bit of caution that if you basically look at the range ... If you start with let's say an LDL of 150 and you go down to let's say an LDL of 25, you are talking about a 1.25% absolute risk reduction. Remember, these patients are possibly going to be a slightly lower risk than the ones that are recruited into the ODYSSEY Outcomes and into the [Fuliay 00:15:46] trial, for example. Dr. Carolyn Lam: I think you mentioned what I was going to just ask you about. This is observational. You had 104 events, and I suppose another limitation might be that your followup was two years at max, if I'm not wrong? What do you say about that, and are there plans for future analyses? Dr. Kausik Ray: Within the context of these studies, I think that the whole of this data will eventually become dwarfed by what we see with the big CDOTs, because you've got 18, 27,000 people, 3 years' worth of exposure and followups, so you are going to have many, many more events. That is a limitation, but I think what is interesting is that we know that the baseline LDL cholesterol level is around about 90 mg/dL. We don't actually know what the actual baseline ... because the baseline [characters 00:16:43] haven't been published for ODYSSEY Outcomes, but the [Fuliays 00:16:46] around about 89. What it tells you is what the point estimate is likely to be. It's likely to be in the 24 to 32% ballpark because that's what your baseline LDL is and that's what we'd predict in the regression lines that we observed here. I think that we're not going to get many more events in these studies because largely the randomized period of followup is now over. Many of these people are now into open labels, extensions for safety, so we won't get many more events from this. In terms of, I think, the way people should maybe look at this is possibly as a taster for what's to come in the next 18 months or so. I think for the time being it answers two questions. Is lower likely to be better? And it is. I think the other question it tells is how might you get people down to LDLs below 50? One of the important things was that if you were just on statins, in this population, if you were recruited on the basis of a high baseline LDL, you got no additional people down to LDLs below 50. You got under 10% with add-on [inaudible 00:18:05], but you got around about 50% when you used the PCSK9 inhibitor as an add-on to existing therapy. It tells you about how to get to such low levels as well. I think that's the other key thing that it actually gives you. We did an analysis of safety [inaudible 00:18:23], and I think that's really important. Once you see the efficacy, or if you see the MACE events continue to go down ... If you looked at treatment-emergent adverse events ... and I completely take the fact that it's every side effect reported altogether, which may or may not be linked to LDL levels specifically, but when we did that, the relationship actually was just a horizontal line, so there was no relationship with percentage reduction or on treatment LDL, so it gave us a nice idea of both safety and efficacy that we might experience in the big outcome studies. Dr. Carolyn Lam: All right. Obviously the big outcome studies are going to be game changers, and I'd really love to invite [Carol Scotts 00:19:09] here, because there's a whole lot of other things that need to be considered if this becomes the case, isn't it? Carol, I really appreciated that you invited an editorial, and the editorial is by Neil Stone who entitles it, Looking Beyond Statins: Will the Dollars Make Cents? Please tell us about the discussions about this paper that occurred. Dr. Carol Lam: I would again like to congratulate Dr. Ray on a fantastic paper, and I would like to reiterate exactly what he said. I think it really does give us some comfort about this class of medication and its relative safety. I think that's very important, because I can't tell you how many patients I get and how many referring physicians I get who worry when their patients come back with LDLs of 20 or below. I think that gave us some comfort, and I do also think it was very important to show that this would fall along the same regression line that statins perhaps would fall. As with all the caveats that Dr. Ray said, I agree with all of them, but I do say this is a tasty little taster, and I appreciate and congratulate you for publishing this. The editorial by Dr. Neil Stone was quite interesting. As you said, he subtitled it, Will the Dollars Make Cents? C E N T S or S E N S E, sort of a play on words there. Will the relative benefits that we can achieve with this class of medications make sense for the cost of these drugs? That's obviously a very separate issue from what was discussed in the manuscript, but it's something to think about. We understand that there are additional patients that will be helped if they can get their LDL down, and we hope that that will translate into the outcomes. Again, just as Dr. Ray mentioned, we will have to wait for the cardiovascular outcomes trials to be completed. When they are, if they do show the benefits that we hope, will their price point make them accessible to enough patients for this to be a widely applied, utilized therapy? Or will they not? That's part of what was discussed in Dr. Stone's editorial. Dr. Kausik Ray: When we were writing the manuscript and stuff like that, and we were doing this and everybody's like, "Oh, wow, look at the graphs." I said, "Look, we need to balance all of these bits and reassure ... We've got an opportunity." So I suggested them giving those additional analyses, and you saw how big the online supplement was. There was a ton of work that we put into this, and to format it into a concise ... I really want to just thank the editorial board for giving us the chance and actually being able to help us and work with us on this, because it's really important. I hope people look at all of those things because it will help people also that question the LDL. They all talk about the hypothesis and the safety of really low LDLs, and people come off statins as a result. I think this will help. Dr. Carolyn Lam: You're listening to Circulation on the Run. Thank you so much for being with us, and don't forget to tune in next week.

In this exclusive interview we talk with Composer Duncan Thum about his role providing a sonic landscape for the second season of Netflix's Chef's Table. Chef's Table goes inside the lives and kitchens of six of the world's most renowned international chefs. Each episode focuses on a single chef and their unique look at their lives, talents and passion from their piece of culinary heaven.

To provide great customer service, bring your agency’s customers to the table. This is one of many insights recently offered by Stephanie Thum, Vice President of Customer Experience at the Export-Import Bank of the United States. Thum has previously written about customer experience for DigitalGov, including Three Ways to Evolve Your Agency’s Customer Mindset and the forward-looking Will 2016 Be the Federal Government’s ‘Year of the Customer?’ In May, Thum sat down with DigitalGov to dig deeper into the federal customer experience (CX) landscape. Thum discussed how the CX mindset is gaining momentum and attention around government, how CX is a management discipline that deserves a seat at the C-suite, and why providing great customer service makes fundamental business sense.

In his fascinating new book, Rian Thum explores the craft, materiality, nature, and readership of Uyghur history over the past 300 years. The Sacred Routes of Uyghur History (Harvard University Press, 2014) argues that understanding Uyghur history in this way is crucial for understanding both Uyghur identity and continuing relationships with the Chinese state. Rather than writing a narrative of “Xinjiang,” Thum instead crafts his history as a story of the shifting spaces of Altishahr, an Uyghur name for “six cities” and a term “used by people who are denied the political power to draw maps.” In Thum’s hands, Altishahr ceases to be a frontier or marginal area: instead, it moves to the center along with the broader field of Uyghur history and historiography. After describing the textual landscape of Altishahri manuscripts as of the beginning of the twentieth century and introducing the genre of the tazkirah as a major vehicle for popular local history, Thum considers the importance of orality to the experience of Altishahri texts, the significance of shrines as spaces of history-making in Altishahr, the ways that the pilgrimage tradition has maintained a shared Altishahri regional identity and view of the past, and the ways that historical fiction and newspapers have helped shape a modern Altishahri historical tradition. Ultimately, Thum also shows how analyzing historical traditions in so-called “marginal” societies can help us understand the nature of history as a practice more broadly conceived. Learn more about your ad choices. Visit megaphone.fm/adchoices

In his fascinating new book, Rian Thum explores the craft, materiality, nature, and readership of Uyghur history over the past 300 years. The Sacred Routes of Uyghur History (Harvard University Press, 2014) argues that understanding Uyghur history in this way is crucial for understanding both Uyghur identity and continuing relationships with the Chinese state. Rather than writing a narrative of “Xinjiang,” Thum instead crafts his history as a story of the shifting spaces of Altishahr, an Uyghur name for “six cities” and a term “used by people who are denied the political power to draw maps.” In Thum’s hands, Altishahr ceases to be a frontier or marginal area: instead, it moves to the center along with the broader field of Uyghur history and historiography. After describing the textual landscape of Altishahri manuscripts as of the beginning of the twentieth century and introducing the genre of the tazkirah as a major vehicle for popular local history, Thum considers the importance of orality to the experience of Altishahri texts, the significance of shrines as spaces of history-making in Altishahr, the ways that the pilgrimage tradition has maintained a shared Altishahri regional identity and view of the past, and the ways that historical fiction and newspapers have helped shape a modern Altishahri historical tradition. Ultimately, Thum also shows how analyzing historical traditions in so-called “marginal” societies can help us understand the nature of history as a practice more broadly conceived. Learn more about your ad choices. Visit megaphone.fm/adchoices

In his fascinating new book, Rian Thum explores the craft, materiality, nature, and readership of Uyghur history over the past 300 years. The Sacred Routes of Uyghur History (Harvard University Press, 2014) argues that understanding Uyghur history in this way is crucial for understanding both Uyghur identity and continuing relationships with the Chinese state. Rather than writing a narrative of “Xinjiang,” Thum instead crafts his history as a story of the shifting spaces of Altishahr, an Uyghur name for “six cities” and a term “used by people who are denied the political power to draw maps.” In Thum’s hands, Altishahr ceases to be a frontier or marginal area: instead, it moves to the center along with the broader field of Uyghur history and historiography. After describing the textual landscape of Altishahri manuscripts as of the beginning of the twentieth century and introducing the genre of the tazkirah as a major vehicle for popular local history, Thum considers the importance of orality to the experience of Altishahri texts, the significance of shrines as spaces of history-making in Altishahr, the ways that the pilgrimage tradition has maintained a shared Altishahri regional identity and view of the past, and the ways that historical fiction and newspapers have helped shape a modern Altishahri historical tradition. Ultimately, Thum also shows how analyzing historical traditions in so-called “marginal” societies can help us understand the nature of history as a practice more broadly conceived. Learn more about your ad choices. Visit megaphone.fm/adchoices

C'est le Walter's Weekly Show, la semaine de Walter, saison 2,  épisode 60 !avec des bêtises dedans !

Sat, 1 Jan 2011 12:00:00 +0100 https://epub.ub.uni-muenchen.de/13969/1/unsichere_Klimafolgen.pdf Thum, Marcel; Konrad, Kai A.; Auerswald, Heike ddc:320, MPI für Steuerrecht und Öffentliche Finanzen, Volkswirtschaft

Sat, 1 Jan 2011 12:00:00 +0100 https://epub.ub.uni-muenchen.de/13959/1/ifo_schnelldiesnst_klimaschutz_artikel_Koautor.pdf Thum, Marcel; Konrad, Kai A.; Feld, Lars P. ddc:320, MPI für Steuerrecht und Öffentliche Finanzen, Volkswirtschaft

As the American soap opera dies off, the telenovela is thriving on Spanish television and now we bring you the titerenovela! We are bringing that unbridled joy to the web, mostly! In our second somewhat romantic webisode of the mildly anticipated next chapter in the love between Conchita & Ronaldo. This time, we find them both in the midst of high Latin drama: The postman is delivering to Conchita while Ronaldo is losing his marbles in the parking lot.

Sat, 24 Jul 2010 12:00:00 +0100 https://edoc.ub.uni-muenchen.de/12576/ https://edoc.ub.uni-muenchen.de/12576/1/Thum_Claudia.pdf Thum, Claudia ddc:5

Mickey Rooney plays part of professional clown Jack Thum in a TV special about the man who spent a lifetime helping poor children. The sound quality on this recording is variable/poor. This archive edition of Letter from America was recorded by one of two listeners, who between them taped and labelled over 650 Letter From America programmes from 1973 to 1989. It was restored by the BBC in 2014.